Heart & Circulation

Heart & Circulation Evidence Ranking

Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.

• A 90 Plant sterols and stanols x Reduction in LDL cholesterol
  Replication across 59-124 RCTs, dose-response, and high-certainty evidence in a 2026 umbrella review support A with 90 points for the LDL-lowering... · View verdict →
• A 88 Oat beta-glucan x Blood cholesterol improvement (LDL-C and total cholesterol)
  Whether enough oat beta-glucan with preserved viscosity and molecular weight is consumed, usually at least 3 g/day, largely determines the effect;... · View verdict →
• B 74 Potassium x Blood pressure
  Increased potassium intake has repeated RCT evidence for blood pressure reduction, but the reduction in clinical events in salt-substitution studie... · View verdict →
• B 62 Red yeast rice (monacolin K, red yeast rice) x Cholesterol improvement
  The LDL-C-lowering efficacy of red yeast rice standardized for monacolin K supports grade B, but greater than 120-fold content variation across mar... · View verdict →
• C 58 Hibiscus (Hibiscus sabdariffa/roselle) x Blood pressure
  Blood-pressure RCTs and meta-analyses are positive, but because this is a surrogate marker, it is upper-end C. · View verdict →
• C 58 Olive leaf extract x Improvement in blood pressure
  A large RCT and meta-analyses show a blood-pressure reduction signal, but surrogate-marker status, formulation heterogeneity, and some negative tri... · View verdict →
• C 55 Garlic (including allicin and aged garlic extract) x Blood pressure and cholesterol
  Blood pressure shows repeated small reductions in RCTs and meta-analyses of hypertensive groups, but cholesterol has a negative large independent R... · View verdict →
• C 55 Artichoke leaf extract x Cholesterol, digestion, and liver
  This is a C judgment mixing blood-lipid and liver-enzyme surrogate markers with small evidence for digestive symptoms. · View verdict →
• C 52 Pomegranate (pomegranate) x Antioxidant, vascular, blood pressure, and skin effects
  Blood-pressure-number improvement is C; extending it to cardiovascular-event prevention or skin efficacy lacks evidence. · View verdict →
• C 50 Niacin (vitamin B3) x Cholesterol and lipids
  Niacin has grade A effects on lipid surrogate markers, but grade D evidence for cardiovascular-event prevention when added to statins and meaningfu... · View verdict →
• C 44 Bergamot polyphenolic fraction x Improvement in LDL and triglycerides
  Positive lipid signals are repeated, but dependence on manufacturers and formulations, study quality, and surrogate-marker limitations are substant... · View verdict →
• C 43 Aronia (aronia/chokeberry) x Antioxidant, blood pressure, and vascular effects
  Human signals are mostly surrogate markers such as blood pressure, oxidative markers, and lipids, and the studies are small. · View verdict →
• C 43 Lycopene x Cardiovascular, prostate
  Because the evidence is centered on surrogate markers and observational studies, this is lower-end C. · View verdict →
• C 40 Celery seed extract (Apium graveolens seed extract, 3nB) x Blood pressure
  This is a single small-study signal on the blood-pressure surrogate marker, so it is lower-end C. · View verdict →
• C 40 Hesperidin x Improvement of blood pressure, endothelial function, and venous circulation
  Pooled blood-pressure results were negative, FMD findings conflict, and venous evidence cannot be attributed to the single ingredient, placing the... · View verdict →
• C 40 Alpha-cyclodextrin x Improvement of postprandial triglycerides, LDL, and body weight
  Only the acute postprandial-triglyceride signal is C; the six-month LDL and weight results were negative and have a D character, yielding an overal... · View verdict →
• D 34 Nattokinase (nattokinase, fibrinolytic enzyme derived from Bacillus subtilis natto) x Blood clots and blood circulation
  There are coagulation and peripheral-blood-flow surrogate-marker signals from small short-term studies, but clinical effects on thrombosis and bloo... · View verdict →
• D 29 Hawthorn leaf and flower extract x Improvement in chronic-heart-failure symptoms, exercise capacity, and blood pressure
  Direct negative HERB and SPICE results on modern standard therapy set the central heart-failure claim at D; lower-C blood-pressure evidence does no... · View verdict →
• C score not listed Omega-3 (EPA/DHA) x cardiovascular and blood-flow improvement
  The evidence is conflicting or limited. · View verdict →
• C score not listed Coenzyme Q10 (ubiquinone/ubiquinol) x antioxidant and blood-pressure improvement
  The evidence is conflicting or limited. · View verdict →
• D score not listed Policosanol (sugarcane-derived) x LDL cholesterol improvement
  Human evidence is insufficient or was not confirmed in key trials. · View verdict →