Bilateral internal thoracic artery grafting in CABG,
does it really help with Improved ten-year overall survival after CABG?
research showsGrade D. In 3,102 ART participants, ten-year mortality was 20.3% versus 21.2%, HR 0.96 (95% CI 0.79 to 1.17), an absolute difference of -0.9 points. The interval leaves tails for benefit and harm, so it does not prove absence of benefit.
ads claimObservational longevity associations should not replace randomized estimates.
Useful facts when choosing a product
- Sternal wound complications were 3.5% versus 1.9%.
- Treatment crossover diluted contrast.
What the research actually shows
Axis 6 B0 evidence ① Allocation concealment: "randomization was performed by means of a secure Web-based system" ② Blinding: procedural masking was impossible; "All the outcome events, including adverse events, underwent adjudication" ③ Analysis set and missingness: "analyses were performed according to the intention-to-treat principle"; 71 (2.3%) lacked final vital status and were censored ④ Prespecified primary endpoint: "The primary outcome was death from any cause at 10 years" - consistent with ISRCTN46552265 MRC and British Heart Foundation funding was public/nonprofit. ART asks whether to use both thoracic arteries during bypass; TASTE asks whether to add aspiration during acute primary PCI.
Why this is classified as D (34)
A large public hard-outcome null trial with harm gives D, 34.
Counterpoint. The interval retains meaningful benefit.
Rejudgment record. Primary-source cross-check — Large publicly funded ten-year survival RCT with null efficacy and increased sternal harm
| Endpoint | H | Hard endpoint - actual events such as death |
| Replication | R1 | Single confirmatory trial |
| Independence | I2 | Decisive evidence is publicly or non-profit funded |
| Effect size | E- | Harm increased in the trials |
| Precision | C0 | The confidence interval leaves room for benefit |
The scoring table and the verdict agree (D).
Cross-check — AI research and Codex final gate
Evidence Table
| Study | Design | Sample | Funding | Endpoint | Result | Weight |
|---|---|---|---|---|---|---|
| Study 1 | Multicenter randomized superiority trial | 3,102 | UK MRC and British Heart Foundation | All-cause death at ten years | 20.3% vs 21.2%; HR 0.96 (95% CI 0.79 to 1.17); absolute difference -0.9 points | Large pivotal hard-outcome trial |
Receipt — 3 References
All 3 cited sources were verified for existence at the original page (as of 2026-08-26).
Final verification and publication gate: Codex · Verification cutoff: 2026-08-26 · Corrections: none
Cite this verdict
[Chamgap] Harm of Bilateral Internal-Thoracic-Artery Grafting for 10-Year Survival and Sternal Wound Complications after CABG — Evidence Grade D·34. 3 cited sources checked. Source: https://chamgap.com/en/verdicts/heart/bilateral-internal-thoracic-artery-cabg-ten-year-survival/ · CC BY 4.0CC BY 4.0 — free to use with attribution; do not distort grades, numbers, or verdict meaning.
What this document does and does not do
Chamgap is an information source. It reports what research has and has not confirmed; it does not tell readers what to take or buy. That decision belongs to readers and, when needed, medical or legal professionals. This verdict reflects literature available up to the search date and may change as new research appears. Nothing here is medical advice.