Verdict No. 3065 · Search date 2026-09-08 · Methodology v1.0
Aged garlic extract; exact daily dose and SAC specification unverified in accessible sources,
does it really help with Improved brachial-artery FMD in men with coronary artery disease?
30-Second Summary
C
Evidence Grade C · 46 · Safety caution
Only an exploratory brachial-FMD signal is judged; PWV, CAVI, blood pressure, and clinical events are separate.
Caution. People with coronary disease taking aspirin or other antiplatelets should not add AGE without reviewing bleeding and interaction risks with their care team.
What the
research showsGrade C with 46 points. In a randomized crossover trial of 15 men with coronary disease, FMD increased 44% from baseline after AGE and was greater than placebo (P=.03 after adjustment for baseline vessel diameter). This was not an absolute between-group percentage-point effect, and the exact dose, 95% CI, registration, and independent replication are unverified, so effect magnitude cannot be established.
research showsGrade C with 46 points. In a randomized crossover trial of 15 men with coronary disease, FMD increased 44% from baseline after AGE and was greater than placebo (P=.03 after adjustment for baseline vessel diameter). This was not an absolute between-group percentage-point effect, and the exact dose, 95% CI, registration, and independent replication are unverified, so effect magnitude cannot be established.
What the
ads claimThis cannot be expanded to reversing atherosclerosis, preventing myocardial infarction, or all garlic products improving vessels.
ads claimThis cannot be expanded to reversing atherosclerosis, preventing myocardial infarction, or all garlic products improving vessels.
Useful facts when choosing a product
- This verdict applies only to the displayed formulation, route, dose, duration, population, endpoint, and comparator.
- Raw garlic, powder, garlic oil, stabilized-allicin products, aged garlic extract, black garlic, fermented garlic, and isolated S-allylcysteine are not interchangeable.
- Caution. People with coronary disease taking aspirin or other antiplatelets should not add AGE without reviewing bleeding and interaction risks with their care team.
Chamgap Semantic Classification Code
Permanent code issued
S.aged-garlic-extract.oral.flow-mediated-dilation.improve.placeboSupplements and nutraceuticals > Aged garlic extract > Oral > Brachial-artery FMD > Improvement claim > Crossover placebo
Issued only for brachial-artery FMD; PWV, CAVI, blood pressure, and cardiovascular events remain separate. The code identifies the intervention and claim; it never contains the evidence grade, score, or safety result.
Exact Claim Classification
These independent facets prevent evidence from different forms, routes, populations, effects, and comparators from being mixed.
| Intervention class | S · Supplement or nutraceutical |
|---|---|
| Canonical ingredient or intervention | Aged garlic extract |
| Source or part used | Aged extract of Allium sativum L. cloves |
| Formulation or processing | Oral AGE; exact specification unverified |
| Route | Oral |
| Dose | Unverified |
| Duration | Two-week treatment; crossover washout details unverified |
| Population | 15 men with coronary artery disease receiving background therapy including aspirin and statins |
| Effect or condition | Improved brachial-artery FMD |
| Primary endpoint | Brachial-artery ultrasound flow-mediated dilation |
| Comparator | Crossover placebo |
| Duplicate-detection key | Aged garlic extract|Oral AGE; exact specification unverified|Oral|15 men with coronary artery disease receiving background therapy including aspirin and statins|Improved brachial-artery FMD|Two-week treatment; crossover washout details unverified |
Gap Measurement · Verdict 3065 · C 46
What the research actually shows
The 2005 FMD trial was checked against a vascular-function review, excluding different device endpoints.
Why this is classified as C (46)
With no confirmed strength, S and EX apply; 15 participants, two weeks, and unverified dose and absolute effect (B2) yield C/46.
Counterpoint. Other AGE studies used CAVI or reflective index rather than FMD and do not independently replicate this endpoint.
Rejudgment record. Independent Codex cross-check — One formulation, route, population, claim, principal endpoint, and comparator
Scoring profile behind this grade
| Endpoint | S | Surrogate marker - laboratory or imaging measures |
| Replication | R1 | Single confirmatory trial |
| Independence | I1 | Mixed funding sources |
| Effect size | EX | The clinical size of the effect could not be judged |
| Precision | CX | No pooled confidence interval could be confirmed |
The scoring table and the verdict agree (C).
Cross-check — AI research and Codex final gate
AI was used for research and drafting. Blind grading, adversarial audit, and the methodology boundary rules were then reapplied before Codex performed the final evidence, grade, copy, and build checks. If a grade cannot be narrowed, both evidence positions and their reasons are published.
Evidence Table
| Study | Design | Sample | Funding | Endpoint | Result | Weight |
|---|---|---|---|---|---|---|
| Aged garlic extract improves endothelial function in men with coronary artery disease | The cited design, allocation, masking, endpoint hierarchy, and analysis limitations were independently checked. | 15 | Funding, product support, employee authorship, and declared conflicts were assessed separately. | The principal endpoint contract is preserved; secondary outcomes remain separate. | Verified estimates are preserved; missing confidence intervals or event counts were not invented. | Evidence weight reflects directness, formulation match, endpoint hierarchy, and reporting limitations. |
Receipt — 1 References
All 1 cited sources were verified for existence at the original page (as of 2026-09-08).
Research and draft: AI used · Cross-check: blind grading and adversarial audit
Final verification and publication gate: Codex · Verification cutoff: 2026-09-08 · Corrections: none
Final verification and publication gate: Codex · Verification cutoff: 2026-09-08 · Corrections: none
Cite this verdict
[Chamgap] Aged Garlic Extract for Endothelial Function—An FMD Signal From a 15-Man Two-Week Crossover Trial — Evidence Grade C·46. 1 cited sources checked. Source: https://chamgap.com/en/verdicts/heart/aged-garlic-extract-coronary-artery-disease-brachial-fmd/ · CC BY 4.0CC BY 4.0 — free to use with attribution; do not distort grades, numbers, or verdict meaning.
What this document does and does not do
Chamgap is an information source. It reports what research has and has not confirmed; it does not tell readers what to take or buy. That decision belongs to readers and, when needed, medical or legal professionals. This verdict reflects literature available up to the search date and may change as new research appears. Nothing here is medical advice.