Joints & Bones

Joints & Bones Evidence Ranking

Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.

• B 70 Vitamin D, bone-health axis x Calcium absorption, prevention of osteomalacia, and reduction of fracture risk
  Established correction of deficiency and fracture prevention through extra supplementation in nondeficient adults are different questions. · View verdict →
• B 62 Avocado-soybean unsaponifiables (ASU) x Improvement of knee osteoarthritis pain and function
  Four placebo-controlled studies with 651 participants found small improvements in knee symptoms, but effect size, product specificity, and heteroge... · View verdict →
• C 55 Vitamin K2 (MK-7, menaquinone-7) x Bone health and vascular calcification/calcium metabolism
  Mechanism and some RCT signals exist, but bone findings for MK-7 alone are not robustly reproduced and vascular evidence is centered on CAC/valve i... · View verdict →
• C 54 Rosehip (Rosa canina) x Joints (osteoarthritis) and antioxidant
  There is a pain-reduction signal from a meta-analysis of 3 RCTs, but because of small scale, small effect, and lack of large independent replicatio... · View verdict →
• C 54 Chrysanthemum zawadskii extract (GCWB106) x Joint and cartilage health and improvement of knee pain
  A randomized human trial exists, but its findings cannot be generalized to every Chrysanthemum product or to cartilage preservation. · View verdict →
• C 50 Gelatin x Joints, skin, and hair
  Standalone gelatin clinical evidence is at a surrogate-marker level, while positive joint, skin, and hair RCTs mostly involve specific hydrolyzed c... · View verdict →
• C 50 Natural eggshell membrane (NEM) x Improvement of knee-joint pain, stiffness, and function
  A small average symptom improvement was pooled, but ingredient-company links and inconsistent primary endpoints place the evidence at C with 52 poi... · View verdict →
• C 48 Undenatured type II collagen (UC-II) x Joint pain, function, and flexibility
  Clinical symptom and function markers improve in several small RCTs and a limited meta-analysis, but key UC-II evidence is short-term, heavily indu... · View verdict →
• C 48 Curcumin (turmeric, curcumin/turmeric) x Anti-inflammatory and joint health
  Short-term relief of pain and functional impairment in knee osteoarthritis is supported at a B level by multiple RCTs and meta-analyses, but genera... · View verdict →
• C 48 Lilium lancifolium extract powder x Improvement of joint discomfort and function
  A human trial prevents an unknown rating, but the finding is not established for Lilium products generally without independent replication. · View verdict →
• C 47 Devil's claw root (Harpagophytum procumbens) x Relief of osteoarthritis and low-back pain
  Specific low-back-pain preparations have short-term signals, but osteoarthritis evidence is weaker and the overall literature is old and heterogene... · View verdict →
• C 45 Calcium (supplement) x Bone health, maintenance of bone mineral density, and fracture prevention
  Bone mineral density rises slightly, but it is a surrogate marker; for fracture prevention, independent large RCTs and recent meta-analyses do not... · View verdict →
• C 44 White willow bark extract x Relief of osteoarthritis pain
  Evidence for S. alba alone is essentially absent, while a positive 78-person trial and a negative 127-person trial of other Salix species conflict,... · View verdict →
• C 42 Milk basic protein (MBP) x Maintenance of bone mineral density and suppression of bone resorption
  Small manufacturer-linked positive trials, a negative BMD result in the larger independent trial, and absence of fracture data support C with 42 po... · View verdict →
• C 40 Boron x Bones, joints, and hormones
  For joints, the evidence is a calcium fructoborate pilot signal; for testosterone, it is an n=8 short-term surrogate-marker study, so this is at th... · View verdict →
• D 35 Chondroitin (chondroitin, mainly chondroitin sulfate) x Claims for joint and cartilage health, improvement of osteoarthritis pain and function, and maintenance of joint space
  The mechanism that the ingredient is a cartilage component, absorption rate, and surrogate markers such as joint space width do not directly transl... · View verdict →
• F 12 Shark cartilage x Joints and anticancer effects
  Because the core anticancer claim was null in a large RCT, this is close to F. · View verdict →
• C score not listed Green-lipped mussel oil (New Zealand green-lipped mussel) x joint pain relief
  The evidence is conflicting or limited. · View verdict →
• C score not listed Boswellia serrata (frankincense) x joint inflammation and pain relief
  The evidence is conflicting or limited. · View verdict →
• C score not listed Collagen (hydrolyzed/UC-II) x joint and bone health
  The evidence is conflicting or limited · View verdict →
• D score not listed Glucosamine x joint (knee) pain and function improvement
  Human evidence is insufficient or was not confirmed in key trials. · View verdict →
• D score not listed MSM (methylsulfonylmethane) x joint pain and function improvement
  Human evidence is insufficient or was not confirmed in key trials. · View verdict →
• ? score not listed Achyranthes root x Joints
  No direct human joint trial of single-ingredient Achyranthes was identified, and combination results are not attributable to Achyranthes alone. · View verdict →
• ? score not listed Strontium citrate x Increased bone mineral density and fracture prevention
  A combination-product DXA signal in 11 participants per group lacks component attribution and valid measurement interpretation, while citrate-alone... · View verdict →