CHAMGAP
CATEGORY HUB

Cognition

Cognition verdicts ranked by evidence score. 174 verdicts in this category.

64 foods and supplements claimed to help cognition, ranked by evidence
Drugs and procedures removed — only what you swallow, ordered by how strong the evidence is.

01

Cognition Evidence Ranking

Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.

A 97 Mechanical thrombectomy (emergency endovascular procedure using a stent retriever or aspiration) Reduced disability and dependence and increased functional independence at 90 days after acute ischemic stroke caused by anterior-circulation large-vessel occlusion
A 93 Aspirin 160 to 300 mg, administered orally in acute care by clinicians Reduced early death and recurrent stroke when started within 48 hours of acute ischemic stroke after intracranial hemorrhage has been excluded
A 90 Carotid endarterectomy (standard vascular surgical procedure, non-drug intervention) Prevention of ipsilateral stroke and stroke death after recent TIA or nondisabling stroke with 70% to 99% carotid stenosis
A 90 Levodopa–carbidopa, a prescription dopamine-precursor and peripheral decarboxylase-inhibitor combination Improvement of tremor, rigidity, and bradykinesia in Parkinson disease
A 86 Alteplase (intravenous thrombolytic tPA, Actilyse, prescription medicine) Reduced 90-day disability and dependence in eligible patients with acute ischemic stroke
A 85 Whole-body therapeutic hypothermia (a neonatal intensive-care procedure) Prevention of death or severe neurodevelopmental disability in neonates with moderate or severe hypoxic-ischemic encephalopathy
A 84 Sumatriptan (a prescription 5-HT1B/1D triptan; Imigran or Sumitran) Two-hour pain freedom and relief of nausea and photophobia during acute migraine attacks in adults
B 79 Organised inpatient stroke-unit care (a multidisciplinary specialist-ward system for admitted patients) Reduced death, dependency, and institutional care after acute stroke
B 78 Anterior temporal lobectomy (prescribed lesion-resection neurosurgery) Sustained freedom from awareness-impairing and all seizures in drug-resistant temporal lobe epilepsy
B 78 Endovascular coil embolization for intracranial aneurysm (prescription neurointerventional procedure) Reduced death or dependency at one year in ruptured intracranial aneurysms suitable for either coiling or clipping
B 77 Nimodipine (a dihydropyridine calcium-channel blocker and oral prescription drug) Prevention of poor neurological outcome, including death or severe disability, after aneurysmal subarachnoid hemorrhage
B 76 OROS methylphenidate (extended-release central nervous system stimulant; controlled prescription drug; Concerta) Reduction of core inattentive, hyperactive, and impulsive symptoms of ADHD in children and adolescents aged six years or older
B 76 Ocrelizumab (anti-CD20 monoclonal antibody, Ocrevus, prescription biologic) Prevention of clinical relapses and sustained disability progression in relapsing multiple sclerosis
B 76 Tenecteplase (modified tissue plasminogen activator thrombolytic; prescription intravenous injection) Reduced disability and dependence and improved functional independence at 90 days in eligible acute ischemic stroke
B 76 Live-attenuated herpes zoster vaccine, Zostavax Reduction or delay of new dementia diagnoses in older adults
B 76 Cataract extraction, usually removal of the cloudy lens with intraocular-lens implantation Reduced incident dementia in older adults
B 76 Targeted temperature management at 33°C for 24 hours after nonshockable cardiac arrest Increased survival with favorable neurologic function at day 90
B 75 Rimegepant (oral calcitonin gene-related peptide receptor antagonist, gepant, and prescription medicine) Freedom from pain and the most bothersome associated symptom two hours after dosing for acute migraine in adults
B 75 Ethosuximide (succinimide antiseizure medicine, Zarontin, prescription medicine) Seizure freedom and prevention of treatment failure in childhood absence seizures
B 74 Topiramate (a sulfamate-substituted antiseizure prescription drug; Topamax) Reduced monthly attack frequency and prevention of migraine in adults
B 74 Valproic acid or sodium valproate (broad-spectrum antiseizure medicine, Depakine, prescription drug) Suppression of seizure recurrence and achievement of 12-month remission in newly diagnosed generalized or unclassifiable epilepsy
B 74 Intramuscular midazolam (benzodiazepine; prescription injection) Seizure cessation before emergency-department arrival in prehospital convulsive status epilepticus
B 74 Perindopril-based blood-pressure-lowering regimen, with or without indapamide Prevention of recurrent stroke after stroke or transient ischemic attack
B 73 Atomoxetine (prescription selective norepinephrine reuptake inhibitor and nonstimulant) Reduced core inattention, hyperactivity, and impulsivity symptoms in adult ADHD
B 73 Early decompressive hemicraniectomy (emergency prescription neurosurgery) Reduced combined risk of death and severe disability when performed within 48 hours for malignant middle cerebral artery infarction
B 72 Hearing aids (air-conduction hearing-assistance medical devices) Improved conversational listening and hearing-related quality of life in adults with mild to moderate hearing loss
B 72 Mechanical thrombectomy for acute basilar-artery occlusion Reduced 90-day disability and increased good functional status after acute basilar-artery occlusion stroke
B 72 Ward protocol for fever, hyperglycemia, and swallowing Reducing death or dependency after acute stroke
B 70 Galantamine (Reminyl, prescription cholinesterase inhibitor) Delayed decline in cognition and daily function in Alzheimer's dementia
B 70 Rivastigmine transdermal patch (prescription AChE and BuChE inhibitor; Exelon) Symptomatic attenuation of cognitive and daily-function decline in mild-to-moderate Alzheimer's disease
B 70 Lacosamide (functionalized-amino-acid antiseizure medicine; Vimpat; prescription medicine) Maintenance of six-month seizure freedom as monotherapy for newly diagnosed focal or primary generalized tonic-clonic epilepsy
B 70 High-flow 100% oxygen (acute inhalation at 12 L/min through a non-rebreather mask) Pain freedom or adequate relief within 15 minutes during an acute cluster-headache attack
B 70 OnabotulinumtoxinA (Botox intramuscular injection) Improvement of abnormal posture, neck pain, and disability in cervical dystonia
B 70 Stroke early supported discharge in which a specialist multidisciplinary team accelerates hospital discharge and continues rehabilitation at home Reduced death or dependency after mild-to-moderate stroke
B 69 Donepezil (cholinesterase inhibitor, prescription drug; Aricept) Symptomatic relief of cognition and daily function in mild-to-moderate Alzheimer dementia
B 69 Lamotrigine (phenyltriazine antiseizure medicine, Lamictal, prescription drug) Suppression of seizure recurrence and 12-month seizure remission in newly diagnosed focal epilepsy
B 68 Carbamazepine (dibenzazepine antiseizure medicine, Tegretol, prescription medicine) Suppression of seizure recurrence and 12-month seizure remission in newly diagnosed focal epilepsy
B 68 Interferon beta-1a (immunomodulatory biologic, Rebif, prescription injection) Prevention of clinical relapses and disability progression in relapsing-remitting multiple sclerosis
B 68 Oxcarbazepine (sodium-channel-blocking antiseizure medicine, Trileptal, oral prescription drug) Maintenance of 24- and 48-week seizure freedom with monotherapy in newly diagnosed focal epilepsy
B 68 Dexamethasone (glucocorticoid, intravenous prescription medicine) Reduced death and poor neurological outcome when given immediately before or with antibiotics in adults with bacterial meningitis
B 68 Ibuprofen, a nonsteroidal anti-inflammatory analgesic Two-hour pain relief during an acute migraine attack
B 66 Riboflavin (vitamin B2) Migraine prevention
B 66 Vortioxetine (Brintellix, prescription antidepressant) Cognitive and processing-speed improvement independent of depression improvement
B 66 Fremanezumab (anti-CGRP monoclonal antibody, Ajovy, prescription medicine) Prevention of episodic and chronic migraine with fewer monthly migraine days
B 65 Memantine (NMDA receptor antagonist, Ebixa, prescription medicine) Delayed decline in cognition and daily function in moderate-to-severe Alzheimer's disease
B 65 Galcanezumab (anti-CGRP monoclonal antibody; Emgality; prescription drug) Reduction in monthly migraine headache days in adults with episodic or chronic migraine
B 64 Atogepant (oral CGRP receptor antagonist, Aquipta, prescription) Reduction in monthly migraine days in adults with episodic or chronic migraine
B 62 Lasmiditan, a prescription selective 5-HT1F receptor agonist ditan sold as Reyvow Pain freedom two hours after dosing for an acute migraine attack
B 60 Creatine monohydrate, cognition axis Improved memory and reasoning during sleep deprivation and in vegetarians
C 59 Acetaminophen or paracetamol (nonopioid analgesic, nonprescription drug; Tylenol) Pain freedom within two hours during an acute episodic tension-type headache
C 58 Blueberry concentrate Improved memory and cognitive function
C 58 Lecanemab (anti-amyloid monoclonal antibody, Leqembi, prescription) Slowing cognitive and functional decline in amyloid-confirmed early Alzheimer's disease
C 58 Cenobamate (antiseizure medicine; Xcopri; prescription medicine) Complete seizure freedom as adjunctive therapy for focal seizures uncontrolled by existing medicines in adults
C 57 Sage extract (Salvia officinalis/lavandulifolia) Improvement of memory and attention
C 56 Habitual intake of edible mushrooms without a specified species Prevention of incident dementia over long-term follow-up
C 56 Ten-year moving-average PM2.5 exposure assigned to residential addresses Higher incidence of dementia
C 56 Periodontitis and tooth-loss status measured by clinical periodontal examination Increased incidence of dementia
C 56 Multicomponent nonpharmacological delirium-prevention care bundle Reduction of incident delirium among adults hospitalized outside intensive care
C 56 Total physical activity measured once by seven-day wrist accelerometry Lower incidence of dementia
C 56 Shift and night work Higher incidence of dementia
C 55 Lion's mane mushroom (Lion's mane, Hericium erinaceus) cognition, memory, and nerves
C 55 Huperzine A (derived from club moss) Memory and cognition
C 55 Lactiplantibacillus plantarum C29-fermented soybean complex (DW2009) Improvement of memory and attention in mild cognitive impairment
C 55 Magnesium Prevention of migraine attacks and reduction in frequency
C 55 Coenzyme Q10, migraine-efficacy axis Reduction in migraine-attack frequency and duration in adults
C 55 OnabotulinumtoxinA (Botox; prescription injection) Reduced monthly headache days in adults with chronic migraine
C 54 Melatonin 3 mg (immediate-release indoleamine supplement or medicine) Reduction of monthly migraine days and prevention of adult migraine
C 54 Propranolol, a nonselective beta blocker Reduction in attack frequency for adult episodic migraine prevention
C 54 Subcutaneous sumatriptan 6 mg Pain freedom or relief within 15 minutes of an acute cluster headache attack
C 54 CEFALY external trigeminal nerve stimulation device Reduction in episodic migraine days with daily preventive use
C 54 Amitriptyline, a tricyclic antidepressant prescribed off label for adult migraine prevention Reduction in monthly migraine days and increased 50% response in adults
C 54 One whole Brazil nut daily Improved cognition in mild cognitive impairment
C 54 Curry meals combining turmeric with other spices, fat, and main ingredients Lower cognitive decline and incidence of mild cognitive impairment or dementia
C 54 Midlife alcohol intake of 1-14 UK units/week (8-112 g ethanol/week) Prevention of incident dementia
C 54 Drinking coffee, at least 28 oz/day, about 828 mL, brewing method unknown Prevention of incident Parkinson disease
C 54 Habitual daytime napping, especially naps shorter than 30 minutes Prevention of cognitive decline and dementia in later life
C 54 A 50-to-55-minute nature walk for adults with major depressive disorder Immediate improvement in working-memory performance
C 54 PDE5 inhibitors Reduced incidence of Alzheimer disease
C 54 Frequency of regular Finnish sauna bathing Reduced incidence of dementia
C 54 Current dog ownership Reduced incident disabling dementia
C 54 Screen exposure at age one, including television, DVDs, games, mobile phones, and tablets More developmental screening delay at ages two and four
C 54 A mobile stroke unit equipped with CT, point-of-care testing, neurologic evaluation, and thrombolysis Reduced disability and increased functional independence at 90 days
C 54 The INTERACT3 early goal-directed care bundle for acute intracerebral hemorrhage Improved functional recovery at six months
C 54 A 36 mg/dL treatment-threshold strategy for neonatal hypoglycemia Noninferior Bayley neurodevelopment at 18 months versus a 47 mg/dL threshold
C 54 Inebilizumab Reduced independently adjudicated NMOSD relapse
C 52 Bacopa monnieri (brahmi) Memory and cognition
C 52 L-tyrosine Stress, focus, and cognitive performance
C 52 Enzymatically hydrolyzed Tremella fuciformis extract Improvement of age-related cognitive function
C 52 Gastrodia elata extract Improvement of memory and cognitive function
C 52 MCT oil (medium-chain triglycerides, C8 and C10) Improved memory and cognitive function in mild cognitive impairment and Alzheimer's disease
C 52 Donanemab (anti-amyloid monoclonal antibody; prescription intravenous Kisunla) Slowed cognitive and functional decline in amyloid-confirmed early symptomatic Alzheimer disease
C 51 Heat-treated green tea extract Improvement of memory and concentration
C 51 L-theanine (a green-tea-derived amino-acid supplement) Improved attention and choice reaction time after a single dose in healthy adults
C 50 Alpha-GPC (alpha-glycerylphosphorylcholine, choline alfoscerate) Cognition and exercise performance
C 50 Acupuncture using true needle treatment Preventive reduction in episodic migraine attack frequency
C 50 Rimegepant, 75 mg orally every other day Reduction in monthly migraine days for adult migraine prevention
C 50 CEFALY external trigeminal nerve stimulation device Increased freedom from pain at two hours during an acute migraine attack
C 50 Nonimmersive virtual-reality rehabilitation using Nintendo Wii upper-limb tasks Superior post-stroke arm recovery versus time-matched recreational activity
C 50 Ubrogepant, an oral CGRP receptor antagonist Freedom from pain and the most bothersome associated symptom two hours after treatment of an acute migraine
C 50 Mixtures of artificial food colors plus 45 mg/day sodium benzoate Increased hyperactivity scores in children from the general population
C 50 Low-protein products with protein redistribution during levodopa therapy Reduced daily motor off time
C 50 Patisiran Improvement in the 18-month mNIS+7 neurologic impairment score in hereditary ATTR amyloidosis with polyneuropathy
C 49 Acetyl-L-carnitine (ALCAR) Cognition and diabetic neuropathy
C 48 Cocoa flavanols (cocoa polyphenols) Cognitive function and vascular/blood-flow health
C 48 High-polyphenol spearmint extract, Neumentix Improvement of working memory and attention
C 46 Magnesium L-threonate (Magtein®) Memory, executive function, and increased brain magnesium
C 46 High-bioavailability curcumin (Theracurmin curcumin, a curcuminoid polyphenol supplement) Improved memory and attention in middle-aged and older adults without dementia
C 46 Mechanical ventilation that lowers indoor carbon dioxide Improved simulated decision-making performance in office workers
C 46 A one-session condition silencing incoming call and text notifications and putting the phone away Fewer sustained-attention task errors
C 46 Action, non-action, and Tetris-like video-game training Improved untrained general cognitive ability
C 45 Ginkgo biloba leaf extract (Ginkgo biloba; flavonoid glycosides and terpenoids/terpene lactones) Memory, cognition, and blood circulation
C 45 Phosphatidylserine (PS) Cognition, memory, and concentration
C 45 Whole coffee fruit extract (NeuroFactor/CognatiQ) Improvement in BDNF, focus, and memory
C 45 Oral magnesium, a mineral supplement supplied in different magnesium salts Reduction of migraine attack frequency in adults
C 44 NVP-2106 probiotic blend of Limosilactobacillus mucosae NK41 and Bifidobacterium longum NK46 Improvement in memory and cognitive function
C 44 Multivitamin-mineral supplement (once-daily oral tablet) Delayed decline in global cognition and episodic memory in older adults
C 43 Saffron extract from Crocus sativus, a botanical supplement containing crocin and safranal Reduced core inattention, hyperactivity, and impulsivity symptoms of ADHD in children and adolescents
C 42 Uridine monophosphate (UMP) Memory, cognition, and synaptic health
C 42 Aster glehni extract powder Improvement of age-related cognitive decline
C 42 Rosemary extract Improved memory and concentration
C 42 Citicoline (CDP-choline, Cognizin, dietary supplement) Improved age-related memory and cognitive function in middle-aged and older adults
C 40 DMAE (dimethylaminoethanol) Improvement in memory and focus
C 40 Polygala tenuifolia root extract Improvement of memory, learning, and forgetfulness
D 34 Dihexa (PNB-0408, research-use peptide-like compound marketed for oral use) Enhanced memory and concentration in healthy adults by promoting synaptogenesis
D 34 Hearing-aid-based hearing intervention (prescription or over-the-counter air-conduction hearing-assistance device) Prevention of cognitive decline and dementia in older adults with hearing loss
D 34 Robot-assisted upper-limb training using the MIT-Manus repetitive-rehabilitation system Superior arm-function recovery after stroke compared with usual rehabilitation
D 34 Pediatric adenotonsillectomy Improved attention and executive function in children with sleep-disordered breathing
D 34 Green leafy vegetables as a group Slower cognitive decline and prevention of dementia
D 34 Frozen cod fillets, 200 g twice weekly from gestational weeks 20 to 36 Improved infant cognitive, language, and motor development at 11 months
D 34 MIND dietary pattern Prevention of cognitive decline
D 34 Ten sessions of adaptive dual-attention speed-of-processing cognitive training Reduction of claims-diagnosed dementia over 20 years in initially healthy adults aged 65 or older
D 34 Night-time earplugs Reduced incidence of strict ICU delirium
D 34 Frequent, higher-dose out-of-bed mobilisation started within 24 hours after stroke in addition to usual stroke-unit care Increase in favorable three-month functional outcome, modified Rankin Scale 0 to 2
D 34 Intracranial arterial stenting added to aggressive medical therapy Reduced recurrent stroke in severe symptomatic intracranial stenosis
D 34 Lying-flat head position for 24 hours after acute stroke Reduced 90-day disability versus sitting up at 30 degrees or more
D 34 Five intravenous doses of high-dose epoetin alfa 1000 IU/kg added to therapeutic hypothermia Reduced death or neurodevelopmental disability in moderate or severe neonatal hypoxic-ischemic encephalopathy
D 30 Phosphatidylcholine/lecithin Cognition and liver
D 30 Donepezil (cholinesterase inhibitor; Aricept; prescription) Prevention of progression from mild cognitive impairment to Alzheimer disease
D 30 High-dose biotin (MD1003, oral biotin 100 mg three times daily) Reversal of walking impairment and disability in progressive multiple sclerosis
D 30 Hyperbaric oxygen therapy (pressurized-chamber oxygen procedure) Improvement of headache, cognitive, and emotional symptoms in persistent postconcussion syndrome
D 30 Percutaneous patent foramen ovale closure Reduced or eliminated migraine attacks in medication-refractory migraine
D 30 Nitrate-rich beetroot juice Cognitive performance and cerebral blood flow in older adults
D 30 Advice to add 1.5 L of water per day to usual intake Reduction in days with at least moderate headache among people with recurrent headaches
D 30 Routine use of aluminum pots, pans, and cookware Increased incidence of dementia or Alzheimer disease
D 30 Periodontitis diagnosis and treatment-need records in national health insurance data Increased incidence of Parkinson disease
D 29 Methylphenidate, a prescription central nervous system stimulant; cognitive enhancement in healthy people is off-label Improved concentration, examination scores, and academic performance in healthy students without ADHD
D 28 HongJam steamed mature silkworm hydrolysate or powder (individually recognized functional ingredient) Improved memory and global cognition in patients with mild cognitive impairment
D 28 Selenium (an antioxidant trace mineral supplement) Prevention of cognitive decline, Alzheimer disease, and dementia in cognitively normal older adults
D 28 Extended-release exenatide (2 mg once-weekly subcutaneous injection) Long-term slowing of motor-symptom progression in Parkinson's disease
D 28 Intranasal regular insulin, 40 IU per day Delay cognitive and daily-function decline in mild cognitive impairment or mild Alzheimer disease.
D 28 Oral gabapentin Prevention of attack frequency in adult episodic migraine
D 28 Whole walnuts, 30 to 60 g daily Prevention of age-related cognitive decline
D 28 Matcha powdered drink, two servings daily, providing 3 g matcha Prevention of overall cognitive decline in older adults
D 28 Hydrogen-dissolved water prescribed at 500 mL/day Slower one-year cognitive decline in mild cognitive impairment
D 28 Oral succimer chelation, also known as DMSA Improved cognitive, behavioral, and neuropsychological development in children with blood lead levels of 20 to 44 µg/dL
D 28 Tofersen Change in the 28-week ALSFRS-R functional score in SOD1 amyotrophic lateral sclerosis
D 26 Scallop- or ascidian-derived plasmalogens in finished memory products Improved memory and global cognition in older adults with mild cognitive impairment
D 25 High-dose vitamin E (alpha-tocopherol) Prevention of dementia and Alzheimer disease in the general older population
D 25 Omega-3 fatty acids (EPA and DHA fish-oil fatty-acid supplement, cognition claim) Prevention of memory decline and incident dementia in cognitively healthy older adults
D 25 EEG neurofeedback (electroencephalographic biofeedback training) Improved attention and core symptoms in children with ADHD
D 22 Pregnenolone (neurosteroid and hormone-precursor supplement) Improved memory, cognition, and brain aging in healthy middle-aged and older adults
F 14 Low-dose aspirin (100 mg; antiplatelet drug) Prevention of dementia, mild cognitive impairment, and cognitive decline in healthy older adults
F 12 Combined vitamins B6, B12, and folate Prevention of dementia and cognitive decline by lowering homocysteine
F 12 OnabotulinumtoxinA, an intramuscular botulinum toxin type A injection Prevention of attack frequency in episodic migraine
F 10 Oral semaglutide 14 mg tablet Delayed cognitive and functional decline in early Alzheimer disease
F 10 Testosterone (1% transdermal gel) Improved memory and cognition in older men with low testosterone
F 10 Bed rest after lumbar puncture instead of immediate mobilization Prevention of post-puncture headache
F 8 Citicoline, or CDP-choline, a choline-related phospholipid precursor sold as a supplement and used as a medicine in some countries Increased 90-day functional independence and neurological recovery after moderate-to-severe acute ischemic stroke
F 8 Coenzyme Q10, including ubiquinone and ubiquinol, a mitochondrial quinone antioxidant supplement Delayed UPDRS functional decline and disease progression in early Parkinson disease
F 8 Creatine monohydrate (a guanidino ergogenic supplement) Delayed long-term clinical progression and functional decline in early Parkinson disease
F 8 High-dose methylprednisolone (prescription systemic glucocorticoid) Improved survival and neurologic recovery after acute traumatic brain injury
F 5 Apoaequorin, marketed as Prevagen Improvement in age-related memory decline and cognitive function
? score not listed N-acetyl-L-tyrosine (NALT, dietary supplement) Greater absorption than ordinary L-tyrosine, leading to improved focus and cognition under stress
? score not listed Cooked whole ginkgo nuts Improved memory