Cognition

Cognition Evidence Ranking

Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.

• B 66 Riboflavin (vitamin B2) x Migraine prevention
  When narrowed to adult 400 mg/day migraine prevention, it corresponds to B because there are direct symptom RCT and guideline evidence. · View verdict →
• C 58 Blueberry concentrate x Improved memory and cognitive function
  Only two memory domains were meta-analytically positive, while other cognitive domains and the latest 24-week trial were null; industry concentrati... · View verdict →
• C 57 Sage extract (Salvia officinalis/lavandulifolia) x Improvement of memory and attention
  Cognitive-task signals are repeated, but small acute trials, extract heterogeneity, and industry concentration result in C with 57 points. · View verdict →
• C 55 Lion's mane mushroom (Lion's mane, Hericium erinaceus) x cognition, memory, and nerves
  Human RCT signals exist, but most studies are small, use inconsistent formulations, have conflicts of interest or insufficient independent replicat... · View verdict →
• C 55 Huperzine A (derived from club moss) x Memory and cognition
  There are small RCT signals in disease populations, but study quality and generalizability problems are substantial, so this is upper C. · View verdict →
• C 52 Bacopa monnieri (brahmi) x Memory and cognition
  Meta-analyses and small RCTs show signals, but there are no large confirmatory independent RCTs or clinical endpoints for preventing cognitive decl... · View verdict →
• C 52 L-tyrosine x Stress, focus, and cognitive performance
  There is a signal for short-term cognitive-performance support in acute high-stress situations, but the scope of application is narrow, so the rati... · View verdict →
• C 52 Enzymatically hydrolyzed Tremella fuciformis extract x Improvement of age-related cognitive function
  The positive 75-person RCT had 15 placebo versus 60 active participants and limitations in developer lineage, process identity, and replication, re... · View verdict →
• C 52 Gastrodia elata extract x Improvement of memory and cognitive function
  The positive 2025 standalone trial conflicts with an earlier overall-population null result and selective small-study findings, resulting in C with... · View verdict →
• C 50 Alpha-GPC (alpha-glycerylphosphorylcholine, choline alfoscerate) x Cognition and exercise performance
  The cognition evidence centers on patients and medicinal doses, while exercise-performance evidence is small, so health-functional-food claims are C. · View verdict →
• C 49 Acetyl-L-carnitine (ALCAR) x Cognition and diabetic neuropathy
  Human studies exist for both neuropathy and cognition, but certainty is low by Cochrane standards. · View verdict →
• C 48 Cocoa flavanols (cocoa polyphenols) x Cognitive function and vascular/blood-flow health
  Vascular outcomes show modest consistent signals in surrogate markers such as FMD and blood pressure, but clinical CVD primary endpoints were not m... · View verdict →
• C 45 Ginkgo biloba leaf extract (Ginkgo biloba; flavonoid glycosides and terpenoids/terpene lactones) x Memory, cognition, and blood circulation
  Large independent RCTs are negative for healthy people, MCI, and dementia prevention, and only limited signals for short-term symptoms in diagnosed... · View verdict →
• C 45 Phosphatidylserine (PS) x Cognition, memory, and concentration
  There is a small positive meta signal in the memory domain, but current plant-based PS alone has negative independent RCTs, and positive evidence i... · View verdict →
• C 45 Whole coffee fruit extract (NeuroFactor/CognatiQ) x Improvement in BDNF, focus, and memory
  There are signals for BDNF and some brief cognitive tests, but manufacturer concentration, small samples, and selective test findings yield C with... · View verdict →
• C 42 Uridine monophosphate (UMP) x Memory, cognition, and synaptic health
  A positive memory result from one manufacturer trial, together with limitations from surrogate and combination evidence, results in C with 42 points. · View verdict →
• C 42 Aster glehni extract powder x Improvement of age-related cognitive decline
  The existence of a human trial is supported, but publicly verifiable cognitive results and independent replication are lacking, resulting in C with... · View verdict →
• C 40 DMAE (dimethylaminoethanol) x Improvement in memory and focus
  Memory was negative in a direct Alzheimer's trial, but focus was positive in two small double-blind or placebo-controlled trials, resulting in C wi... · View verdict →
• D 30 Phosphatidylcholine/lecithin x Cognition and liver
  Cognitive efficacy leans toward no benefit in a Cochrane RCT review, but because the judgment is not centered on harm, it is D with 30 points. · View verdict →