Women's Health

Women's Health Evidence Ranking

Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.

• B 63 Complex extract including Cynanchum wilfordii (EstroG-100: Cynanchum wilfordii/Cynanchum, Phlomis umbrosa, and Angelica gigas complex) and pomegranate extract/pomegranate concentrate x Relief of menopausal symptoms in women
  Because there are multiple human symptom RCTs, the grade is B, but it is the lower end of B because Cynanchum wilfordii is a complex extract rather... · View verdict →
• B 60 Vitamin B6 (pyridoxine) x PMS (premenstrual syndrome) and morning sickness
  Morning sickness is B based on direct symptom RCTs and ACOG recommendations, while PMS is a combined claim closer to C because of small studies and... · View verdict →
• C 58 Chasteberry (Vitex agnus-castus/chasteberry) x PMS and premenstrual syndrome
  There are direct symptom-scale RCT signals for PMS, but they are concentrated in specific standardized-extract/product studies. · View verdict →
• C 58 Siberian rhubarb extract (ERr 731) x Relief of menopausal hot flashes and symptoms
  The effect size is large, but absent independent replication and concerns about duplication, heterogeneity, and publication bias in the meta-analys... · View verdict →
• C 56 Inositol (myo-inositol/D-chiro-inositol) x PCOS, mood, and blood glucose
  There are PCOS metabolic-marker signals, but clinical efficacy, mood, and general glucose claims are low-certainty and surrogate-marker centered, s... · View verdict →
• C 54 Flaxseed (lignans, flaxseed) x menopausal symptoms (hot flashes/night sweats), gut health (constipation/bowel movements), cholesterol (LDL/total cholesterol)
  Flaxseed has human evidence for LDL/total cholesterol and constipation, but 'lignan relief of menopausal hot flashes' repeatedly failed to hold in... · View verdict →
• C 52 Fennel seed extract x Relief of menopausal symptoms
  Positive and null trials of overall menopausal-symptom scores coexist, producing limited and conflicting evidence rated C with 52 points. · View verdict →
• C 50 MS-10 thistle complex x Relief of menopausal symptoms in women
  Human RCTs exist, but they are concentrated around one branded ingredient and its developer network, resulting in C with 50 points. · View verdict →
• C 48 Red clover isoflavones x Relief of menopausal hot flashes and night sweats
  A null 252-person large trial and Cochrane synthesis conflict with a modestly positive 2026 meta-analysis, resulting in C with 48 points. · View verdict →
• C 48 Shatavari (Asparagus racemosus) x Improvement of menopausal symptoms and female sexual function
  RCTs of 70, 80, and 135 participants exist, but eight-week duration, multiple self-reported endpoints, commercial-ingredient concentration, and no... · View verdict →
• C 46 Soy isoflavones (soy isoflavones; genistein, daidzein, glycitein, etc.) x Menopausal symptoms in women, especially vasomotor symptoms such as hot flashes/night sweats
  There are small and heterogeneous RCT signals for hot flashes, but when broadened to menopausal symptoms overall, independent RCTs and recent meta-... · View verdict →
• C 46 Sophora japonica fruit extract x Menopausal women’s health and improvement in the Kupperman Index
  One developer-linked 87-person RCT of a sophoricoside-standardized fruit extract found only a borderline symptom signal, resulting in C with 46 poi... · View verdict →
• C 43 Diindolylmethane (DIM) x Estrogen balance and PMS improvement
  Specific estrogen metabolites change, but the clinical meaning of 'balance' is unestablished and no human PMS trial exists, resulting in C with 43... · View verdict →
• C 42 Gamma-oryzanol (derived from rice bran) x Cholesterol, menopause, autonomic nervous system
  Human studies exist, but surrogates and old subjective ratings predominate, and direct exercise and hormone RCT evidence was largely null. · View verdict →
• C 40 Germinated fermented soybean extract x Relief of menopausal symptoms in women
  Regulatory registration and trial preregistration confirm that a human study exists, but efficacy magnitude and reliability cannot be verified with... · View verdict →
• D 36 Pueraria root (kudzu root, Pueraria/kudzu, puerarin) x Menopause and hangover
  For Pueraria root, evidence for menopause and hangover efficacy is insufficient and graded D because species confusion and indirect endpoints are m... · View verdict →
• D 33 Black cohosh (black cohosh, Cimicifuga/Actaea racemosa) x Menopausal symptoms (hot flashes)
  The primary results from high-quality independent trials are weak, and there is a liver-safety issue. · View verdict →
• D 27 Wild yam extract x Menopausal symptoms and a 'natural progesterone' effect
  The direct human trial was null for both symptoms and progesterone, while evidence depends on one small trial, supporting D with 27 points. · View verdict →
• F 15 Evening primrose oil (gamma-linolenic acid, GLA; in the domestic market often advertised together with GLA-containing oils such as borage oil and blackcurrant oil) x PMS (discomfort due to premenstrual changes) and skin (immune hypersensitivity/atopic dermatitis, dryness, itching)
  For skin/atopy, 27 Cochrane RCTs were null versus placebo; for PMS, EPO-alone RCTs were generally null, and positive PMS evidence is from a GLA com... · View verdict →