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Gut & Digestion

Gut & Digestion verdicts ranked by evidence score. 166 verdicts in this category.

72 foods and supplements claimed to help gut and digestion, ranked by evidence
Drugs and procedures removed — only what you swallow, ordered by how strong the evidence is.

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Gut & Digestion Evidence Ranking

Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.

A 93 Helicobacter pylori eradication therapy (oral triple or quadruple therapy) Prevention of incident gastric cancer in asymptomatic infected people
A 92 Once-only flexible sigmoidoscopy screening (lower-colon endoscopic procedure) Reduced distal colorectal cancer incidence and colorectal cancer mortality in asymptomatic middle-aged adults
A 88 School and childcare hand-washing promotion program (public-health program combining soap provision and hygiene education) Prevention of diarrhoea episodes in children
A 85 Omeprazole (proton pump inhibitor, Losec, prescription and nonprescription medicine) Mucosal healing and heartburn resolution in erosive reflux esophagitis
A 84 Psyllium husk (psyllium husk; dietary fiber from Plantago ovata/Plantago spp. seed husk) Smooth bowel movements and improvement of blood cholesterol
B 79 Loperamide, an antidiarrheal drug Reduced duration and stool frequency in adults with acute non-bloody diarrhea
B 79 Mesalazine/mesalamine (prescription 5-aminosalicylic acid intestinal anti-inflammatory drug; Pentasa) Induction and maintenance of clinical remission in mild-to-moderate ulcerative colitis
B 78 Lactase enzyme Prevention of bloating and diarrhea from lactose intolerance
B 78 Macrogol 4000 (polyethylene glycol 4000, PEG 4000) Improvement in bowel-movement frequency and stool form in chronic functional constipation
B 78 Vedolizumab (prescription biologic monoclonal antibody against alpha4beta7 integrin; Kynteles/Entyvio) Induction of clinical response and maintenance of remission in moderate-to-severe ulcerative colitis with inadequate response to prior treatment
B 77 Fecal microbiota transplantation (donor-derived microbial procedure) Clinical cure and prevention of recurrence in multiply recurrent Clostridioides difficile infection
B 77 Combined Bifidobacterium and Lactobacillus probiotics (live biotherapeutic given enterally under clinical supervision) Prevention of severe necrotizing enterocolitis and all-cause mortality in preterm or low-birth-weight infants
B 76 Limosilactobacillus reuteri DSM 17938 Reduced crying time in breastfed infants with colic
B 76 Vonoprazan plus amoxicillin (potassium-competitive acid blocker plus penicillin dual therapy; prescription regimen) Eradication and cure of Helicobacter pylori infection in treatment-naive adults
B 76 Tofacitinib (oral Janus kinase inhibitor; prescription Xeljanz) Induction and 52-week maintenance of clinical remission in moderate-to-severe ulcerative colitis refractory to previous treatment
B 76 Aspirin (an antiplatelet cyclooxygenase inhibitor available by prescription and over the counter) Long-term prevention of colorectal cancer in carriers of Lynch syndrome
B 76 Preoperative oral antibiotics added to intravenous prophylaxis for elective colorectal surgery Reduced 30-day surgical-site infection versus intravenous prophylaxis alone
B 76 One 0.5 mL dose of Vi-tetanus-toxoid typhoid conjugate vaccine, Typbar-TCV Prevention of blood-culture-confirmed typhoid over two years in children aged 9 months to 15 years in an endemic setting
B 76 Hybrid Ivor-Lewis esophagectomy with laparoscopic abdominal mobilization and open thoracotomy Reduction of major intraoperative or 30-day complications
B 76 Intravenous pantoprazole for stress-ulcer prophylaxis Reduced clinically important upper gastrointestinal bleeding in invasively ventilated ICU patients
B 76 Laparoscopic distal gastrectomy Noninferior five-year overall survival versus open surgery in clinical stage I gastric cancer
B 76 Two days of postoperative intravenous antibiotics Noninferiority to five days for 90-day infection or death after surgery for complex appendicitis
B 76 Neoadjuvant FOLFOX with selective radiation Noninferior disease-free survival and radiation de-escalation versus standard chemoradiotherapy
B 76 Transanal total mesorectal excision Noninferior 3-year disease-free survival versus laparoscopic TME in mid-to-low rectal cancer
B 75 Bezlotoxumab (C. difficile toxin B monoclonal antibody, Zinplava, prescription infusion) Prevention of recurrent C. difficile infection after standard antibiotic treatment
B 75 Lateral internal sphincterotomy (prescribed anal-sphincter decompression surgery) Complete healing and prevention of recurrence in medically refractory chronic anal fissure
B 75 Appendectomy (prescribed laparoscopic or open surgery) Definitive treatment and long-term recurrence prevention for CT-confirmed uncomplicated acute appendicitis in adults
B 75 Oral vancomycin (prescription glycopeptide antibiotic capsule) Clinical cure of severe Clostridioides difficile infection
B 74 Saccharomyces boulardii Diarrhea, gut health
B 74 Senna leaf and sennosides (Senna alexandrina; stimulant laxative) Improved bowel-movement frequency and symptoms in adults with chronic functional constipation
B 74 Infliximab (anti-TNF-alpha monoclonal antibody, Remsima, prescription biologic) Reduction in colectomy risk through 54 weeks in moderate-to-severe ulcerative colitis
B 72 Fructooligosaccharides (FOS; prebiotics) Gut health and smoother bowel movements
B 72 Sodium picosulfate (nonprescription stimulant laxative; Dulcopurl) Improvement in complete spontaneous bowel-movement frequency and stool status in chronic constipation
B 72 Misoprostol (prostaglandin E1 analogue, Cytotec, oral prescription drug) Prevention of serious upper gastrointestinal complications such as bleeding and perforation in long-term NSAID users
B 72 Albendazole (benzimidazole anthelmintic, nonprescription medicine) Parasitological cure of intestinal soil-transmitted nematode infections including ascariasis and hookworm
B 72 Capecitabine (oral fluoropyrimidine prodrug, prescription anticancer medicine) Prevention of recurrence and death as adjuvant monotherapy after complete resection of stage III colon cancer
B 72 Low-dose aspirin (160 mg/day as an oral tablet) Reduced postoperative recurrence of localized colorectal cancer with a PI3K-pathway alteration
B 72 Helicobacter pylori eradication therapy combining antibiotics with acid suppression Prevention of recurrence after healing of Helicobacter-positive peptic ulcer
B 72 Intravenous ondansetron 4 mg, a 5-HT3 antagonist antiemetic Prevention of nausea and vomiting during the first 24 hours after surgery
B 72 Single-dose oral ondansetron, a prescription 5-HT3 receptor antagonist antiemetic Reduced vomiting during oral rehydration and reduced intravenous-fluid use in pediatric acute gastroenteritis
B 72 Daily rifaximin chemoprophylaxis during travel Prevention of travelers' diarrhea
B 72 Half-strength apple juice in the emergency department followed by preferred fluids Fewer seven-day treatment failures in young children with mild gastroenteritis and minimal dehydration
B 72 Non-crosslinked porcine collagen biological mesh placed deep to the abdominal wall during stoma closure Reduction of clinically detected stoma-site incisional hernia within two years
B 72 Laparoscopic rectal-cancer resection Noninferior 3-year locoregional recurrence versus open rectal-cancer resection
B 70 Peppermint oil (enteric-coated peppermint oil) Irritable bowel syndrome (IBS)
B 70 Bisacodyl Improvement of bowel-movement frequency and symptoms in adults with chronic functional constipation
B 70 Tenapanor (50 mg orally twice daily, prescription) Concurrent improvement in abdominal pain and complete spontaneous bowel movements in IBS-C
B 69 Linaclotide (guanylate cyclase-C agonist, oral prescription capsule) Improved complete spontaneous bowel movement frequency and sense of complete evacuation in chronic idiopathic constipation
B 68 Ginger (gingerol) digestion, anti-inflammatory effects, and nausea
B 66 Prucalopride (5-HT4 agonist; prescription drug) Normalization of spontaneous complete bowel movements in chronic idiopathic constipation inadequately responsive to laxatives
B 66 Famotidine (prescription and nonprescription H2-receptor blocker) Relief of heartburn and gastroesophageal reflux symptoms and healing of erosive esophagitis
B 65 Lactiplantibacillus plantarum 299v Relief of IBS abdominal pain, gas, and bloating
B 64 Sodium alginate, or alginate Relief of gastroesophageal reflux and heartburn symptoms
B 63 Lactulose Improvement of bowel-movement frequency and stool consistency in chronic constipation
B 62 Curcumin Adjunctive induction and maintenance of remission in ulcerative colitis
B 60 Inulin (chicory-derived/chicory root) Gut health, bowel movements, and blood glucose
B 60 Bismuth subsalicylate (nonprescription medicine) Reduced stool frequency and duration in acute nonbloody, nonbacterial diarrhea
C 59 Lubiprostone (prescription chloride-channel activator; Amitiza) Improvement of spontaneous and complete bowel movements in adults with chronic idiopathic constipation
C 59 Fidaxomicin (narrow-spectrum macrocyclic antibiotic, Dificid, prescription drug) Clinical cure of Clostridioides difficile infection and reduced post-treatment recurrence
C 59 SER-109 or Vowst (fecal microbiota spores, live-brpk oral spore capsules) Prevention of recurrent C. difficile infection after antibacterial treatment
C 58 Acacia fiber, gum arabic, including Fibregum® Bowel-movement frequency, stool characteristics, and beneficial gut bacteria
C 58 Low-FODMAP diet (restriction followed by staged reintroduction and personalization) Relief of abdominal pain, bloating, and global symptoms in irritable bowel syndrome
C 58 Rifaximin 550 mg (oral) Relief of global symptoms in irritable bowel syndrome without predominant constipation
C 57 Vonoprazan (potassium-competitive acid blocker; Voquezna or Takecab; prescription medicine) Endoscopic healing and maintenance of healing in erosive esophagitis
C 56 Processed meat such as bacon, ham, and sausage, per 50 g/day increment Increased colorectal cancer incidence
C 56 Grilled or barbecued red meat Increased colorectal-cancer incidence
C 56 Alcohol consumption during regular aspirin or nonsteroidal anti-inflammatory drug use Increased major upper gastrointestinal bleeding requiring hospitalization or transfusion
C 56 See title and evidence table for the studied intervention. The stated clinical outcome in the title.
C 56 Organized outreach that directly mails FIT kits to adults overdue for screening and reminds nonreturners Increased completion of colorectal cancer screening within a defined period
C 56 Oral cryotherapy during conditioning-drug infusion before allogeneic hematopoietic stem-cell transplantation Reduced WHO grade 3-4 severe oral mucositis
C 55 Partially hydrolyzed guar gum (PHGG) Gut health, bowel movements, IBS
C 55 Galactooligosaccharides (GOS) Improvement of constipation and stool frequency, and increased bifidobacteria
C 55 Bacillus coagulans Unique IS-2 Bowel regularity and constipation improvement
C 55 Green kiwifruit powder (Actazin) Improvement in bowel frequency, stool form, and abdominal discomfort in functional constipation
C 54 Alpha-galactosidase Reduction of gas and bloating after beans or high-FODMAP meals
C 54 Gut-directed hypnotherapy (standardized hypnosis, education, and home-practice psychotherapy) Relief of abdominal pain, bloating, and global symptoms of irritable bowel syndrome
C 54 Naldemedine, a peripherally acting mu-opioid receptor antagonist Improvement of opioid-induced constipation in chronic noncancer pain
C 54 Upadacitinib, an oral selective JAK inhibitor marketed as Rinvoq Induction and maintenance of clinical remission in moderate-to-severe ulcerative colitis
C 54 Omeprazole 20 mg taken 20 to 30 minutes before the first meal Improved reflux symptoms versus other existing dosing times
C 54 Alcohol-based hand sanitizer provision plus enhanced hand-hygiene education during international travel Lower incidence of travelers' diarrhea
C 54 Low-dose titrated amitriptyline Improved six-month symptom severity in irritable bowel syndrome persisting after diet and first-line treatment
C 54 Intravenous risankizumab induction Week-12 clinical remission and endoscopic response in moderate-to-severe Crohn's disease
C 53 Magnesium oxide Improvement of chronic constipation and bowel-movement frequency
C 52 Kimchi-derived probiotics (plant-derived lactic acid bacteria) gut health
C 50 Multi-enzyme digestive supplement Improved digestion and bloating in the general population
C 50 Zinc L-carnosine, including polaprezinc and PepZin GI Gastric-mucosal protection and gastric-ulcer healing
C 50 Enhanced recovery after colorectal surgery (ERAS or fast-track colorectal surgery, a multicomponent perioperative care program) Reduced complications and 30-day readmission after colorectal surgery
C 50 Adalimumab (subcutaneous anti-TNF monoclonal-antibody prescription biologic; Humira and biosimilars) Induction and maintenance of clinical remission in moderate-to-severe Crohn disease
C 50 Methylnaltrexone, a peripherally acting mu-opioid receptor antagonist Rapid rescue-free laxation in opioid-induced constipation during advanced illness
C 50 Dupilumab, an interleukin-4 receptor alpha monoclonal antibody given by weekly subcutaneous injection Improvement of dysphagia in adults and adolescents with eosinophilic esophagitis
C 50 Fig paste, 300 g daily Improved colonic transit and bowel symptoms in functional constipation
C 50 Whole koji amazake More defecation days and bowel movements
C 50 Whole-grain provided diet Increased bowel-movement frequency
C 50 Decaffeinated coffee, a single 300-mL serving Reduced three-hour postprandial esophageal acid exposure in reflux disease
C 50 A single 300 mL serving of nonfermented milk containing only A2 beta-casein Reduced acute gastrointestinal symptoms in adults who report discomfort after ordinary milk
C 50 Whole dried dill-leaf powder, 3 g/day Relief of colonic-motility-related symptoms in adults with type 2 diabetes
C 50 Regular coffee, 100 to 150 mL three times daily after colorectal surgery Shorter time to first bowel movement
C 50 The food emulsifier carboxymethylcellulose, or CMC Altered gut microbiota and metabolites with induction of human intestinal inflammation
C 50 A 14-day positional device that vibrates in the right lateral position to promote left-side sleep Relief of nighttime heartburn and reflux symptoms
C 50 Probiotics across multiple strains and formulations Prevention of antibiotic-associated diarrhea in adults
C 50 Prunes, 100 g per day Improved complete spontaneous bowel movements and stool consistency in chronic constipation
C 50 Wedge pillow Relief of nocturnal gastroesophageal reflux symptoms
C 50 A toilet footstool (Squatty Potty) that raises the knees above the hips while seated Less straining, shorter defecation time, and greater sense of complete evacuation
C 50 Swedish-style abdominal massage added to lifestyle advice Reduced constipation severity over four weeks in functional chronic constipation
C 50 Real-time computer-aided detection Increased adenoma detection rate during colonoscopy
C 48 Aloe (aloe vera; aloe gel/whole leaf/latex must be distinguished) gut health, bowel movements, and skin health
C 48 Xylooligosaccharides (XOS) Improved bowel movements and increased bifidobacteria
C 46 Tegoprazan (potassium-competitive acid blocker, K-CAB, prescription) Faster and superior heartburn relief and erosive-esophagitis healing versus proton-pump inhibitors
C 46 Fexuprazan (potassium-competitive acid blocker, P-CAB, Fexuclue, prescription) Faster and superior nocturnal heartburn relief and erosive-esophagitis healing versus PPIs
C 46 Two liters of mineral water daily with a 25-g/day fiber diet Increased stool frequency and reduced laxative use in adults with chronic functional constipation
C 46 1.5 L/day of carbonated mineral water Improved functional dyspepsia and early satiety
C 46 Alkaline water above pH 8 combined with a 90% plant-based Mediterranean-style diet Improved laryngopharyngeal reflux symptoms
C 46 Sugar-free chewing gum added to standard care after abdominal surgery Shorter time to first postoperative flatus
C 46 An abdominal castor-oil pack Improvement of constipation
C 46 Daily structured abdominal breathing training Reduced esophageal acid exposure in gastroesophageal reflux disease
C 45 Heat-killed lactic acid bacteria (postbiotics, paraprobiotics, heat-treated cultured bacterial cells) Superiority claim that they are clinically better than live probiotics
C 45 Bromelain (pineapple enzyme) Digestive support and relief of inflammation/edema
C 45 Butyrate salts (butyrate) IBS abdominal pain and bloating, and improved intestinal barrier
C 45 Honeysuckle flower-bud extract GreenCera-F (GCWB104) Protection of the gastric mucosa and improvement of stomach health
C 44 Manuka honey (MGO/UMF) Stomach health, Helicobacter pylori, GERD symptoms, and immunity
C 42 Racecadotril (prescription enkephalinase-inhibiting antidiarrheal) Reduced duration and stool output in pediatric acute watery diarrhea
C 42 Mosapride (prescription 5-HT4 gastrointestinal prokinetic, marketed as Gasmotin) Improvement of early satiety, postprandial fullness, and overall symptoms in functional dyspepsia
C 40 ABC juice (apple, beet, carrot) and cabbage juice Stomach health and detoxification
C 40 Cassia seed (Cassia obtusifolia/Senna obtusifolia seed) Eyes, constipation
C 40 Mastic gum (Pistacia lentiscus) Functional dyspepsia and Helicobacter suppression
C 40 2′-Fucosyllactose (2′-FL, human milk oligosaccharide supplement) Improved adult gut microbiota and irritable bowel syndrome symptoms
C 40 Trimebutine maleate (gastrointestinal motility regulator, Polybutin, prescription or nonprescription) Improvement of overall irritable bowel syndrome symptoms including abdominal pain
D 34 Dioctahedral smectite (diosmectite), a nonprescription intestinal adsorbent silicate marketed as Smecta Shorter recovery time from acute watery diarrhea in adults
D 34 Regular coffee above 1,400 g per day, about six 237-mL cups or 1.4 L Prevention of incident invasive colon cancer
D 34 Early aggressive goal-directed fluid resuscitation for acute pancreatitis Improved clinical outcomes and fluid overload
D 34 Early enteral nutrition in critically ill adults Reduced 28- to 30-day mortality compared with early parenteral nutrition
D 34 Routine prophylactic pelvic suction drainage after rectal cancer excision with low infraperitoneal anastomosis Prevention of pelvic sepsis within 30 days
D 32 Boswellia serrata (a boswellic-acid triterpene herb used as a supplement) Induction of clinical remission in active ulcerative colitis or chronic colitis
D 32 Folic acid, the synthetic supplemental form of vitamin B9 Prevention of new polyp or adenoma recurrence after colorectal adenoma removal
D 30 Clostridium butyricum MIYAIRI 588 probiotic Improvement of abdominal pain and bowel symptoms in diarrhea-predominant irritable bowel syndrome
D 30 A silicone nipple shield added to structured lactation support Continuation of exclusive breastfeeding to six months among mothers with nipple abnormalities
D 30 Prophylactic broad-spectrum antibiotics in severe or necrotizing acute pancreatitis without confirmed infection Prevention of infected pancreatic necrosis and death
D 30 Routine nasogastric decompression maintained until passage of flatus or stool after elective hepatectomy Prevention of pneumonia and pulmonary complications
D 28 Probiotics (lactic acid bacteria) gut health and improved bowel movements
D 28 Lion's mane mushroom (Hericium erinaceus, a polysaccharide-containing functional mushroom supplement) Gastric-mucosal protection and lesion healing in gastritis and gastric ulcer
D 28 Mesalazine or mesalamine (prescription 5-ASA intestinal anti-inflammatory drug) Improvement of abdominal pain, global symptoms, and stool frequency in irritable bowel syndrome
D 28 Unpasteurized organic whole raw milk Improved lactose digestion and lactose-intolerance symptoms versus pasteurized milk
D 28 A breakfast of 50 g fruit granola with 200 mL milk Greater bowel-movement frequency than a cornflake breakfast
D 28 Gluten avoidance in people without celiac disease Relief of abdominal pain, bloating, and other gastrointestinal symptoms
D 28 P6 Neiguan acupressure band Reduced nausea from motion sickness
D 28 Home syrup of ipecac after childhood poisoning Reduced emergency-department referral or use and fewer adverse outcomes
F 15 Simethicone (Mylicon, nonprescription antifoaming agent) Reduced crying and symptoms caused by infantile colic
F 12 Docusate sodium Softening stool to improve constipation
F 12 Lacticaseibacillus rhamnosus GG, or LGG, supplied as oral capsules or powder Reduced severity and diarrhea duration in pediatric acute infectious gastroenteritis
? score not listed Slippery elm bark (Ulmus rubra) Soothing acid reflux, heartburn, and a sensitive gut
? score not listed Betaine hydrochloride (Betaine HCl) Correction of hypochlorhydria and improvement of impaired protein digestion
? score not listed Ox bile extract (bovine bile acids) Improved fat digestion and fat-soluble vitamin absorption after cholecystectomy
? score not listed Triphala (a three-fruit Ayurvedic combination ingredient) Improved bowel-movement frequency and completeness in chronic or functional constipation
? score not listed Black walnut–wormwood–clove complex (multi-herb supplement) Removal of intestinal parasites or a parasite cleanse
? score not listed Tributyrin (butyrate-precursor supplement) Improved intestinal permeability or leaky gut and relief of irritable bowel syndrome symptoms
? score not listed Marshmallow root (Althaea officinalis, herbal product) Relief of gastroesophageal reflux and gastrointestinal irritation, with protection and repair of intestinal mucosa
? score not listed Gluten digestive enzyme blend containing DPP-IV, including supplements marketed around AN-PEP-like activity Prevention of accidental gluten exposure and intestinal mucosal injury in celiac disease
? score not listed Caprylic acid (octanoic acid; C8 medium-chain fatty-acid supplement) Eradicate intestinal Candida overgrowth and improve bloating when taken orally
? score not listed Bone-broth protein (an animal-derived food supplement containing collagen and gelatin) Improvement of leaky gut and intestinal permeability and restoration of the intestinal barrier
? score not listed Irish sea moss (Chondrus crispus, a carrageenan-containing red-seaweed supplement) Increase of beneficial gut bacteria and improvement of constipation, bloating, and irritable bowel syndrome in humans
? score not listed KPV tripeptide, Lys-Pro-Val, sold as oral capsules or a research peptide Relief of inflammatory bowel disease or so-called leaky-gut symptoms by improving intestinal inflammation and permeability.
? score not listed Whole daikon radish or radish juice (Raphanus sativus) Relief of functional dyspepsia symptoms
? score not listed Whole Korean melon including seeds and placenta Constipation relief and more frequent bowel movements
? score not listed Dried persimmon Shorter acute diarrhea, fewer stools, or improved stool consistency
? score not listed Unpasteurized makgeolli 300 mL/day, about 14.2 g ethanol if 6% ABV Improved bowel movements and constipation relief
? score not listed About one persimmon eaten with one serving of properly cooked crab Combination-specific poisoning, abdominal pain, or diarrhea