Real-time computer-aided detection,
does it really help with Increased adenoma detection rate during colonoscopy?
research showsThe grade is C with 50 points. Histology-confirmed adenoma detection was 187/341 (54.8%) with CADe versus 139/344 (40.4%), an absolute increase of 14.4 percentage points and RR 1.30 (95% CI 1.14 to 1.45). ADR is a detection-rate surrogate, not colorectal cancer incidence or mortality, so the grade is capped at C.
ads claimSouth Korean hospitals market AI-assisted endoscopy in checkup programs. Detection assistance must not be advertised as proven reduction in colorectal cancer mortality.
Useful facts when choosing a product
- Adenomas per colonoscopy were 1.07 versus 0.71, IRR 1.46 (95% CI 1.15 to 1.86).
- Non-neoplastic resection was 26.0% versus 28.8%, with no difference.
- Mean withdrawal time was 417 versus 435 seconds, without a clear difference.
What the research actually shows
Three Italian centers randomized 700 patients and analyzed 685 (341/344). Endoscopists could not be blinded to real-time prompts, but blinded pathologists confirmed the objective primary endpoint, so an unblinded subjective endpoint does not apply. Limitation: inadequate randomization or allocation concealment. Listed item: inadequate randomization or allocation concealment. Avoidability: possible - the center-specific stratified random lists could have been implemented and reported through secure central release after enrollment. Exclusion was 15/700 (2.1%), below substantial attrition (>=15%). The paper calls the study nonprofit with no cash funding, but acknowledgments and conflicts disclose a Medtronic equipment loan and Medtronic consulting fees to Repici and Hassan, so it is not classified as publicly independent.
Why this is classified as C (50)
The primary endpoint is a detection-rate surrogate, capping the grade at C. A 14.4-point absolute ADR gain is balanced against one RCT, Medtronic equipment and author consulting, and unreported concealment, giving C with 50 points.
Counterpoint. Verdict 1716 is C with 52 points, verdict 1473 is A with 92 points, and verdict 2511 is C with 56 points. Those ask whether screening occurs or reduces cancer incidence and death; this verdict asks whether an ongoing colonoscopy detects more.
Rejudgment record. New verdict — Histology-confirmed ADR increase, detection-rate cap, equipment loan and author conflicts, and unreported concealment
| Endpoint | S | Surrogate marker - laboratory or imaging measures |
| Replication | R1 | Single confirmatory trial |
| Independence | I1 | Mixed funding sources |
| Effect size | E+ | Meets the clinically important threshold |
The scoring table and the verdict agree (C).
Sub-claim grades by effect
This ingredient is marketed for several effects. A single overall grade blends strong and weak claims together, so each effect is graded separately here. The overall grade reflects the strongest disconfirming or core claim.
| Effect (sub-claim) | Grade | Basis |
|---|---|---|
| Higher adenoma detection rate during colonoscopy | C | ADR increased by 14.4 percentage points. |
| Reduced colorectal cancer incidence or mortality | D | The trial did not measure long-term patient outcomes. |
Cross-check — Codex and Claude
Evidence Table
| Study | Design | Sample | Funding | Endpoint | Result | Weight |
|---|---|---|---|---|---|---|
| Study 1 | Open randomized trial at three Italian centers with blinded pathology | 344 | Medtronic equipment loan; Medtronic consulting fees to Repici and Hassan | ADR: proportion with at least one histologically proven adenoma or carcinoma | 54.8% vs 40.4%; absolute difference +14.4 points; RR 1.30 (95% CI 1.14 to 1.45) | Pivotal detection-rate surrogate RCT |
Receipt — 2 References
All 2 cited sources were verified for existence at the original page (as of 2026-08-18).
Reviewed and approved: Chamgap Editorial Team · Approval date: 2026-08-18 · Corrections: none
Cite this verdict
[Chamgap] Real-Time Computer-Aided Detection During Colonoscopy for Adenoma Detection Rate — Benefit — Evidence Grade C·50. 2 cited sources checked. Source: https://chamgap.com/en/verdicts/gut/real-time-ai-cade-colonoscopy-adenoma-detection/ · CC BY 4.0CC BY 4.0 — free to use with attribution; do not distort grades, numbers, or verdict meaning.
What this document does and does not do
Chamgap is an information source. It reports what research has and has not confirmed; it does not tell readers what to take or buy. That decision belongs to readers and, when needed, medical or legal professionals. This verdict reflects literature available up to the search date and may change as new research appears. Nothing here is medical advice.