Skin & Hair

Skin & Hair Evidence Ranking

Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.

• B 60 Zinc x Acne and skin
  There is evidence for direct clinical endpoints in acne lesion counts and severity, but it does not extend to claims about skin overall. · View verdict →
• C 49 Polypodium leucotomos extract x Oral ultraviolet protection and erythema reduction
  The MED and sunburn signal in a 40-person RCT is a surrogate for clinical prevention, and a combination follow-up is not single-ingredient replicat... · View verdict →
• C 47 Ingredients claimed to express aquaporin (AQP3). Representative: glyceryl glucoside. Ingredients that are claimed together but whose cited evidence does not confirm AQP3/skin-moisture matching (such as resurrection plant, aloe, trimethylglycine, etc.) are separated as “claimed but evidence not matched.” x Skin moisture
  Evidence is conflicting or limited · based on topical (cosmetic) use · oral use lacks evidence · View verdict →
• C 46 Proteoglycan (from salmon nasal cartilage) x Skin and joints
  The positive skin results come from small manufacturer-linked trials without independent replication, while the full-cohort joint clinical endpoint... · View verdict →
• C 44 Elastin (hydrolyzed elastin peptides) x skin elasticity and wrinkles
  The evidence is conflicting or limited · View verdict →
• C 44 Keratin (oral keratin) x Hair and nails
  There is an RCT signal for a specific ingredient, but the evidence is manufacturer- and product-specific. · View verdict →
• C 44 Choline-stabilized orthosilicic acid x Improvement in skin elasticity and wrinkles, hair, and nails
  Evidence is limited to skin-roughness and hair-cross-sectional-area surrogates in manufacturer-supported ch-OSA-specific trials, resulting in C wit... · View verdict →
• C 44 Amla (Phyllanthus emblica) x Improvement in female pattern hair loss and hair growth
  Only the hair-cycle ratio was positive in one RCT, while hair count and thickness were negative; age imbalance and no replication result in C with... · View verdict →
• C 43 Vitamin C (ascorbic acid) x Skin and collagen production
  The fact that it is an essential nutrient is strong, but the evidence for skin efficacy of general supplements is centered on surrogate markers. · View verdict →
• C 40 Squalene (from shark/olive sources) x Skin and immunity
  Human intervention studies exist, but they lack placebo controls and involve unrealistic high doses, surrogate outcomes, and inconsistent reporting. · View verdict →
• D 35 Probiotics (specific strains) x Atopic dermatitis and eczema
  The key evidence for the treatment claim remains at symptom and QoL no-difference findings and a SCORAD difference below the MCID. · View verdict →
• D 27 Para-aminobenzoic acid (PABA) x Prevention of gray hair and restoration of hair color
  Only old uncontrolled combination observations are available, with no monotherapy controlled trial, resulting in D with 27 points. · View verdict →
• B score not listed Low-molecular-weight collagen (collagen peptides) x Skin hydration and elasticity
  There are many human studies, but most were funded by companies that sell collagen · View verdict →
• C score not listed Glutathione (oral) x Whitening and skin tone
  There are small studies, but they conflict with one another, and no study has ever shown the full path through to "it becomes brighter because you... · View verdict →
• C score not listed Pantothenic acid (vitamin B5) x skin and hair-loss improvement
  The evidence is conflicting or limited · View verdict →
• C score not listed Oral hyaluronic acid x skin moisturization
  The evidence is conflicting or limited · View verdict →
• C score not listed Oral ceramides (rice- and wheat-derived) x skin moisturization and barrier
  The evidence is conflicting or limited · View verdict →
• D score not listed Biotin (vitamin B7) x hair-loss improvement and hair growth
  Human evidence is insufficient or was not confirmed in key trials. · View verdict →
• D score not listed Brewer’s yeast x hair-loss relief and hair
  Human evidence is insufficient or was not confirmed in key trials · View verdict →
• ? score not listed L-cystine x Improvement in diffuse hair loss and hair growth
  Combination evidence prevents attribution to L-cystine alone; the rating is indeterminate. · View verdict →
• ? score not listed Millet seed extract (Panicum miliaceum) x Reduction in hair loss and hair growth
  Combination evidence prevents attribution to single-ingredient millet seed extract alone; the rating is indeterminate. · View verdict →