2% hydrogen-peroxide cleansing,
does it really help with Increased percentage of skin-graft take at 21 days?
research showsThe grade is C. In 49 Iranian patients with bilateral limb wounds, right-side wounds received five minutes of 2% hydrogen peroxide followed by saline and grafting, while left-side wounds received conventional debridement and saline before grafting. Mean 21-day take was 82.85% versus 65.61%, P<0.05. Yet fixed right-side treatment was not true randomized allocation, and no mean-difference CI, SD, or exact P value allowed effect-size standardization; graft area was also a surrogate rather than closure or reoperation, giving C with 46 points.
ads claimThis intraoperative five-minute 2% treatment of debrided chronic burn wounds cannot be turned into evidence for repeatedly disinfecting ordinary abrasions with pharmacy peroxide. Concentration, wound type, exposure time, saline rinse, and surgical supervision all differ.
Useful facts when choosing a product
- The trial applied 2% hydrogen-peroxide gauze for five minutes, rinsed with saline, and grafted immediately.
- Graft take was the 21-day percentage of grafted area retained, not complete closure, infection, or reoperation.
- Existing peroxide or wound verdicts address different indications; no direct duplicate of the selected PMID or DOI was found.
Chamgap Semantic Classification Code
Candidate index · review held
UNK.cleansing-of-chronic-colonized-burn-wounds-with-2-percent-hydrogen-peroxide-gauze-immediately-before-grafting.UNK.percentage-of-skin-graft-take-at.increase.UNKUnknown > cleansing of chronic colonized burn wounds with 2% hydrogen peroxide gauze immediately before grafting > Unknown > percentage of skin-graft take at > Increase claim > Unknown
An automated migration candidate, not an issued permanent code; exact claim scope remains under review. This machine-generated migration candidate helps retrieval but is not a permanent assignment. The original verdict ID and URL remain authoritative.
What the research actually shows
Mohammadi prospectively compared 98 limbs in 49 patients with bilateral chronic colonized burn wounds. Right wounds were debrided, treated with 2% hydrogen-peroxide-soaked gauze for five minutes, rinsed with saline, and grafted; left wounds received conventional debridement, saline, and grafting. Although the title called it randomized, treatment side was fixed, and a later evidence map classified it as a nonrandomized intra-individual comparison. A surgeon estimated 21-day graft-take area, with assessor masking unconfirmed. No registration or complete Funding or Acknowledgment text was identified.
Why this is classified as C (46)
A positive human comparison exists, but it measured only a 21-day surrogate and combined 49 participants, fixed-side assignment, uncertain masking, and inadequate effect-size reporting, giving C with 46 points.
Counterpoint. C does not mean the surgical procedure is definitively ineffective; it means one promising signal awaits replication and clinical outcomes.
Rejudgment record. Cross-check applied — We cross-checked patient and limb denominators, fixed right-versus-left assignment, concentration, duration, saline rinse, the 21-day graft-area outcome, and effect-reporting limits against the PubMed record and later evidence map.
| Endpoint | S | Surrogate marker - laboratory or imaging measures |
| Replication | R1 | Single confirmatory trial |
| Independence | I1 | Mixed funding sources |
| Effect size | EX | The clinical size of the effect could not be judged |
Stored derived and displayed grades match; this is not a current recalculation or validity check (C).
Sub-claim grades by effect
This ingredient is marketed for several effects. A single overall grade blends strong and weak claims together, so each effect is graded separately here. The overall grade reflects the strongest disconfirming or core claim.
| Effect (sub-claim) | Grade | Basis |
|---|---|---|
| Intraoperative 2% hydrogen-peroxide cleansing increases 21-day graft-take area in chronic colonized burns. | C | Mean take was 82.85% versus 65.61% in 49 patients, but assignment was fixed by side and no effect CI was reported. |
| Using the same treatment for routine home disinfection of ordinary wounds improves healing. | ? | The study involved debridement, saline rinse, and immediate grafting of chronic burns, not ordinary home wound care. |
Cross-check — AI research and Codex final gate
Evidence Table
| Study | Design | Sample | Funding | Endpoint | Result | Weight |
|---|---|---|---|---|---|---|
| Mohammadi et al., split-limb chronic-burn comparison 2013 | Prospective single-center within-person comparison with fixed right intervention and left control | 49 patients and 98 limbs analyzed | Funding or acknowledgment text was not confirmed | Surgeon-assessed percentage of graft take at 21 days | Mean 82.85% versus 65.61%, difference 17.24 points, P<0.05; no SD, SE, mean-difference CI, or exact P value reported | Only direct human study, but fixed-side nonrandomized assignment and a surrogate outcome |
Receipt — 2 References
All 2 cited sources were verified for existence at the original page (as of 2026-08-14).
Final verification and publication gate: Codex · Evidence date: 2026-08-14 · Corrections: none
Cite this verdict
[Chamgap] 2% hydrogen-peroxide cleansing x skin-graft take in chronic burns — Evidence Grade C·46. 2 cited sources checked. Source: https://chamgap.com/en/verdicts/skin-hair/hydrogen-peroxide-chronic-burn-wound-skin-graft-take/ · CC BY 4.0CC BY 4.0 — free to use with attribution; do not distort grades, numbers, or verdict meaning.
What this document does and does not do
Chamgap is an information source. It reports what research has and has not confirmed; it does not tell readers what to take or buy. That decision belongs to readers and, when needed, medical or legal professionals. This verdict reflects literature available up to the search date and may change as new research appears. Nothing here is medical advice.