Eye

Eye Evidence Ranking

Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.

• B 60 Vitamin A (retinol/beta-carotene) x Eye health, night blindness, skin, and immunity
  Evidence for correcting deficiency and for night blindness and xerophthalmia corresponds to B, but claims of general eye, skin, and immune improvem... · View verdict →
• B 60 Maqui berry extract (Aristotelia chilensis) x Improvement in dry eye and tear production
  Tear volume and patient symptoms were replicated across two placebo-controlled RCTs, but supplied-ingredient concentration and small samples result... · View verdict →
• C 59 Palmitoylethanolamide (PEA) x Adjunctive support for intraocular pressure and glaucoma
  The intraocular-pressure surrogate is repeatedly positive, but total samples are small and clinical glaucoma-progression outcomes remain uncertain,... · View verdict →
• C 58 Tisochrysis lutea powder x Improvement of dry-eye symptoms and tear secretion
  The primary OSDI endpoint was positive, but objective measures were partial and no independent replication exists, resulting in C with 58 points. · View verdict →
• C 57 Grape-skin enzymatic fermented extract (KL-GEFE) x Improvement of dry eye and tear-film measures
  One RCT found concurrent improvement in symptoms and tear-film measures, but it was a single developer-linked study, resulting in C with 57 points. · View verdict →
• C 56 Centella asiatica extract powder x Maintenance of macular pigment density and eye health
  One randomized trial supports improved MPOD, but there are no visual-function or macular-degeneration prevention outcomes and no independent replic... · View verdict →
• C 55 Astaxanthin (astaxanthin, Haematococcus extract) x eye fatigue, skin health, and antioxidant effects
  Human RCTs and a skin meta-analysis exist, but most are small, short-term, industry-funded, and centered on surrogate markers, so C is the limit fo... · View verdict →
• C 49 Persimmon-leaf ethanolic extract x Improvement of dry eye
  Several dry-eye measures were positive, but the evidence is one company-funded preprint centered on completer analysis, resulting in C with 54 points. · View verdict →
• C 47 Purple corn cob and husk extract powder x Improvement of dry eyes
  A human trial was conducted, but no public literature permits independent verification of its results, resulting in C with 47 points. · View verdict →
• C 46 Bilberry extract (anthocyanins/anthocyanosides) x eye fatigue, eye health, vision/night vision, and dry-eye-related claims
  Eye fatigue has surrogate-marker signals from industry-funded small RCTs, but improvement of vision and night vision is not supported by more direc... · View verdict →
• C 45 Perilla leaf extract x Eye-fatigue relief
  Small brief studies found an accommodation signal, but independent replication and clinical symptom data are insufficient, resulting in C with 45 p... · View verdict →
• C 44 Sea buckthorn oil (Hippophae rhamnoides) x Dry-eye symptoms and tear-film improvement
  A single manufacturer-linked RCT showed limited signals in selected endpoints alongside many null endpoints, resulting in C with 44 points. · View verdict →
• C 43 Goji berry (wolfberry, Lycium barbarum/goji berry) x Eye, fatigue, immunity, antioxidant
  Eye and antioxidant signals are mostly surrogate markers, and direct clinical evidence for fatigue and immunity is weak, so this is C. · View verdict →
• C 43 Gardenia-derived crocetin x Improvement of eye fatigue and accommodation
  Only one positive small manufacturer-linked crossover trial is available, resulting in C with 43 points. · View verdict →
• C 42 Dried Tetraselmis chuii powder x Improvement of dry eye and tear secretion
  A human study exists in the regulatory dossier, but its results cannot be independently checked in public, resulting in C with 42 points. · View verdict →
• D 32 Omega-3 (EPA/DHA) x Dry eye disease
  Because the primary endpoint in an independent large RCT was null, this is D. · View verdict →
• C score not listed Lutein and zeaxanthin x macular health and eye health
  The evidence is conflicting or limited. · View verdict →
• ? score not listed Chrysanthemum flower (Chrysanthemum indicum) x Eye-fatigue relief and vision protection
  Kan 2020 tested a C. morifolium combination, and no oral monotherapy RCT exists for C. indicum, so the grade is ?. · View verdict →
• ? score not listed Eyebright (Euphrasia officinalis) x Eye-fatigue relief and vision protection
  Eye-drop studies exist, but there is no efficacy literature for oral eyebright on the target outcomes, so the grade is ?. · View verdict →