Lutein, zeaxanthin, curcumin, and vitamin D3 combination capsule,
does it really help with Improved tear volume and dry-eye symptoms?
research showsGrade C. At day 56, OSDI changed from 30.10±4.88 to 17.09±4.85 with the supplement and from 32.54±5.06 to 31.00±7.18 with placebo, with between-group P=.0001. Schirmer tear volume also improved more with the supplement (P<.0001). Both coprimary endpoints were positive, but this was a small eight-week manufacturer trial.
ads claimThis evidence concerns the fixed four-ingredient formulation. It cannot be decomposed into benefit from lutein, curcumin, or vitamin D alone or generalized to another blend.
Useful facts when choosing a product
- The capsule contained lutein 20 mg, zeaxanthin 4 mg, curcuminoids 200 mg, and vitamin D3 600 IU.
- The placebo was a visually matched soybean-oil capsule.
- Follow-up lasted 56 days.
What the research actually shows
The Indian single-center double-blind trial randomized 60 adults with mild-to-moderate dry eye, 30 per group, to the supplement or matched soybean-oil placebo for eight weeks; 59 completed. Coprimary outcomes were day-56 Schirmer tear volume and OSDI symptoms, and both were positive. The paper's tables did not report 95% confidence intervals for the between-group effects. No prespecified clinically important minimum Schirmer-mm or OSDI difference was identified.
Why this is classified as C (50)
Both coprimary endpoints succeeded, but short, small, complete-case evidence from one company lineage gives C with 50 points.
Counterpoint. Symptoms and tear volume improved together, but long-term durability and company-independent replication remain unestablished.
Rejudgment record. Cross-check applied — Positive coprimary endpoints in a 60-person, eight-week complete-case trial from one company development lineage
| Endpoint | S | Surrogate marker - laboratory or imaging measures |
| Replication | R1 | Single confirmatory trial |
| Independence | I0 | Evidence comes only from manufacturer studies |
| Effect size | E+ | Meets the clinically important threshold |
The scoring table and the verdict agree (C).
Sub-claim grades by effect
This ingredient is marketed for several effects. A single overall grade blends strong and weak claims together, so each effect is graded separately here. The overall grade reflects the strongest disconfirming or core claim.
| Effect (sub-claim) | Grade | Basis |
|---|---|---|
| Improved day-56 tear volume and OSDI | C | Both coprimary endpoints were positive. |
| Reduced artificial-tear use | D | The follow-up between-group P value was .562. |
Cross-check — AI research and Codex final gate
Evidence Table
| Study | Design | Sample | Funding | Endpoint | Result | Weight |
|---|---|---|---|---|---|---|
| Study 1 | Double-blind placebo-controlled randomized trial | 59 | Supported by OmniActive Health Technologies, which manufactured and supplied product and placebo and participated in formulation development; four OmniActive employee authors (Priyanka Radkar, Abhijeet Morde, Deshanie Rai, and Muralidhara Padigaru) | Coprimary day-56 Schirmer tear volume and OSDI | Between-group P=.0001 for OSDI and P<.0001 for Schirmer; 95% CIs not reported | Pivotal manufacturer trial |
| Study 2 | Multicenter double-blind placebo-controlled randomized trial | 116 | Trial funded by OmniActive; publication costs and medical-writing and editorial support provided by Bausch + Lomb; three OmniActive employee authors (AM, DR, MP), two Bausch + Lomb employee authors (RR, KB), and four Bausch + Lomb advisory-board members (NG, JG, JP, LP) | Day-56 Schirmer and OSDI | Both favored supplement (P<.001); artificial-tear use P=.562 | Same direction but not independent replication |
Receipt — 2 References
All 2 cited sources were verified for existence at the original page (as of 2026-08-26).
Final verification and publication gate: Codex · Verification cutoff: 2026-08-26 · Corrections: none
Cite this verdict
[Chamgap] Benefit of Lutein, Zeaxanthin, Curcumin, and Vitamin D3 for Tear Volume and Dry-Eye Symptoms — Evidence Grade C·50. 2 cited sources checked. Source: https://chamgap.com/en/verdicts/eye/lutein-zeaxanthin-curcumin-vitamin-d-dry-eye/ · CC BY 4.0CC BY 4.0 — free to use with attribution; do not distort grades, numbers, or verdict meaning.
What this document does and does not do
Chamgap is an information source. It reports what research has and has not confirmed; it does not tell readers what to take or buy. That decision belongs to readers and, when needed, medical or legal professionals. This verdict reflects literature available up to the search date and may change as new research appears. Nothing here is medical advice.