Sleep

Sleep Evidence Ranking

Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.

• B 68 Tart cherry (Montmorency, Prunus cerasus) x improving sleep quality/sleep duration and post-exercise muscle recovery
  There are repeated signals for objective sleep indicators and post-exercise MVC recovery, but studies are small, heterogeneous, and often industry-... · View verdict →
• B 64 Saffron extract, including affron, sleep-efficacy axis x Improvement of sleep onset and sleep quality
  Sleep-specific trials do exist, but mood and depression results should not be repurposed as sleep efficacy, and proprietary-ingredient concentratio... · View verdict →
• B 61 Lemon verbena extract (Aloysia citrodora) x Improvement of sleep quality and stress
  The independent 100-person trial and a separate 71-person trial support B for sleep, while null PSS results support C for stress; the overall grade... · View verdict →
• C 56 Heukharang lettuce extract (Lactuca sativa) x Improved sleep quality and sleep onset
  One positive RCT covered subjective and objective sleep measures, but independent accumulation and sleep-onset evidence are insufficient, resulting... · View verdict →
• C 55 Lactium (milk protein hydrolysate, alpha-s1-casein-derived) x sleep and stress relief
  For sleep, there are standalone RCT signals, but they are centered on subjective diaries, with core questionnaires and PSG mixed; for stress, the e... · View verdict →
• C 52 GABA (gamma-aminobutyric acid, oral) x Stress and sleep
  There is a signal for shortened sleep onset, but it is centered on small manufacturer-supported RCTs, and stress evidence is mainly HRV, hormone, a... · View verdict →
• C 50 Glycine x Sleep
  There are small RCT signals for 3 g before bedtime, but independent large-scale replication is lacking. · View verdict →
• C 50 Rice bran ethanolic extract x Improved sleep duration, sleep efficiency, and sleep onset
  Objective polysomnographic signals exist, but this was one supplier-linked two-week trial analyzing 42 participants, and PSQI was null, resulting i... · View verdict →
• C 50 Glycine x Improved sleep quality and daytime alertness when taken before bed
  Human randomized trials exist, but samples of only 7 to 19 participants, subjective outcomes, and concentration in an Ajinomoto-linked research net... · View verdict →
• C 49 L-theanine x sleep and tension relief
  The evidence is conflicting or limited · View verdict →
• C 49 Ecklonia cava extract (phlorotannins) x sleep
  The core is not perceived sleep improvement but a WASO reduction signal in a 1-week small PSG study, with insufficient total PSQI and independent r... · View verdict →
• C 48 Melatonin x sleep
  There is relatively consistent clinical evidence for sleep rhythm and jet-lag adaptation, but universal sleep-improvement effects in general adult... · View verdict →
• C 47 L-tryptophan x Sleep and mood
  Sleep signals are small, and mood evidence is insufficient by Cochrane standards, so the grade is C. · View verdict →
• C 44 Valerian (Valeriana officinalis) x sleep and anxiety
  For sleep, there is a subjective improvement signal, but objective/quantitative indicators and independent large RCTs are inconsistent; for anxiety... · View verdict →
• C 42 L-serine x Improvement in sleep quality and nighttime awakenings
  Subjective sleep scores were positive, but objective nighttime awakenings showed only a trend and there is no independent replication, yielding C w... · View verdict →
• C 40 Hops (Humulus lupulus) x Sleep and anxiety
  There are more combination-product and food studies than sleep evidence for hops alone. · View verdict →
• D score not listed Magnesium x sleep improvement and eye-twitching relief
  Human evidence is insufficient or was not confirmed in key trials. · View verdict →
• ? score not listed Apigenin x Sleep quality and tension relief
  There is no human efficacy trial of isolated apigenin for the stated effects, so the grade is ? and the score is null. · View verdict →
• ? score not listed Magnolia bark extract (honokiol and magnolol) x Improvement of anxiety, stress, and sleep
  There is no direct single-ingredient human efficacy trial and only combination-product results, so the grade is ? and the score is null. · View verdict →
• ? score not listed Jujube seed (Ziziphus jujuba var. spinosa) x Improvement in insomnia and sleep quality
  Jujube-seed-containing formulas have a C-level signal, but the absence of human efficacy literature for the seed alone makes the grade unknown. · View verdict →
• ? score not listed California poppy (Eschscholzia californica) x Improvement in sleep onset and sleep quality
  There is no single-ingredient human efficacy literature, and identified results concern only valerian combinations, so the grade is unknown. · View verdict →
• ? score not listed Wild lettuce extract (Lactuca virosa) x Sedation, sleep onset, and restful sleep
  No standalone human sleep-efficacy literature was identified, so the rating is unknown; preclinical evidence was not forced into a D rating. · View verdict →