Energy & Fatigue

Energy & Fatigue Evidence Ranking

Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.

• C 55 Octacosanol x fatigue and endurance
  Endurance has small exercise-time signals, but fatigue is mainly inferred from surrogate indicators and exercise performance, and most studies are... · View verdict →
• C 52 Vitamin B1 (thiamine) x Fatigue and nerve function
  Evidence for deficiency correction is strong, but evidence for general fatigue and energy enhancement in non-deficient people is weak, so the gener... · View verdict →
• C 50 B-complex vitamins x Fatigue
  In general fatigue without deficiency, the key limitation is that the evidence is not independently replicated proof of a B-vitamin-specific effect... · View verdict →
• C 50 Fermented porcine placenta extract x Improvement of fatigue
  One RCT was positive for FSS and IL-1 beta, but the LG-linked HORUS material, per-protocol analysis, subgroup findings, and no independent replicat... · View verdict →
• C 48 Taurine x Fatigue and vitality
  For everyday fatigue, direct RCT evidence is insufficient and the representative direct fatigue RCT was negative; the small signal for exercise dur... · View verdict →
• C 47 Schisandra chinensis (schisandra) x Fatigue, liver, and antioxidant effects
  For fatigue, liver, and antioxidant claims, human RCT signals exist, but they center on surrogate markers such as strength, lactate, ALT/AST, and o... · View verdict →
• C 47 PQQ (pyrroloquinoline quinone) x Energy and cognition
  Positive results on objective cognitive tests were repeated, but all trials were manufacturer-linked and there is no independent replication. In th... · View verdict →
• C 46 Rhodiola (Rhodiola rosea) x Fatigue and stress
  Positive RCTs exist, but most are small, tied to specific standardized extracts and products, and a rigorous independent RCT was negative, so indep... · View verdict →
• C 46 Cordyceps (including C. militaris, C. sinensis/Cs-4, and Cordyceps mycelium culture extract) x Vitality, immunity, and exercise
  For immunity, NK/IgA surrogate markers are positive but URI reduction failed; exercise/vitality evidence is small, combination-product, and mixed,... · View verdict →
• C 46 Vitamin B12 (cobalamin) x Fatigue and anemia
  There is evidence for B12-deficiency anemia, but fatigue-recovery claims in normal B12 status are negative or insufficient. · View verdict →
• C 44 Royal jelly x Fatigue recovery and increased vitality
  Mixed fatigue results in special patient groups and an 18-person exercise trial result in C with 44 points. · View verdict →
• C 44 Theacrine (TeaCrine) x Improvement of alertness, energy, and fatigue
  Small subjective alertness signals exist, but independent replication is weak and objective performance is repeatedly null, resulting in C with 44... · View verdict →
• C 43 Eleuthero/Siberian ginseng (Eleutherococcus senticosus) x Fatigue, stress, and exercise
  Human studies exist, but they are small, conflicting, and centered on subgroup signals, so the grade is C. · View verdict →
• C 42 Arginine (L-arginine) x fatigue and vitality
  The core assumption is that blood-flow, ammonia, and exercise-performance surrogate indicators lead to perceived fatigue and everyday vitality, but... · View verdict →
• C 42 Iron (for non-deficient ordinary people) x Fatigue
  The positive evidence comes from correcting deficiency or low ferritin, and cannot be directly extrapolated to fatigue improvement in non-deficient... · View verdict →
• C 42 NADH (nicotinamide adenine dinucleotide hydride) x Improved chronic fatigue
  Monotherapy trials conflict and later positive evidence uses a combination, resulting in C with 43 points. · View verdict →
• C 40 D-ribose x Improved fatigue in chronic fatigue syndrome and fibromyalgia
  The CFS and fibromyalgia evidence is limited to uncontrolled self-report, while a 17-person healthy-adult crossover trial was null, resulting in C... · View verdict →
• C 40 Fermented amino acid complex x Fatigue reduction during endurance exercise
  Public clinical data and independent replication for the specific composition are sparse, while general BCAA endurance findings are inconsistent, r... · View verdict →
• F 15 Deer velvet antler x Improved physical performance and exercise recovery
  Repeated null sports-performance RCTs and unconvincing isolated positive signals result in F with 15 points. · View verdict →