Liver

Liver Evidence Ranking

Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.

• C 56 NAC (N-acetylcysteine) x liver, respiratory health, and antioxidant effects
  Evidence for NAC reducing COPD/chronic-bronchitis exacerbations is acknowledged, but the core evidence for liver detox, antioxidant, and general lu... · View verdict →
• C 55 Hovenia dulcis fruit extract (HDE; hovenic acid) x Liver health and hangover
  Hangover has small human RCT signals, but liver health is centered on surrogate markers and animal evidence rather than human clinical outcomes, so... · View verdict →
• C 52 Artemisia annua extract powder x Liver protection and liver-function improvement
  The multicenter RCT was positive for liver enzymes, but one SPB-201 trial, surrogate endpoints, and no independent replication limit efficacy to C... · View verdict →
• C 50 Choline: choline bitartrate, phosphatidylcholine/lecithin, citicoline/CDP-choline, and alpha-GPC/choline alfoscerate x Liver health/fatty liver and cognition/memory
  Choline is essential for preventing deficiency, but advertised 'liver health plus memory' supplementation effects rely on small, surrogate, formula... · View verdict →
• C 50 Ecklonia stolonifera extract x Liver health and liver-enzyme improvement
  The liver-enzyme result in one 12-week RCT was positive, but manufacturer linkage, small size, surrogate endpoints, and no independent replication... · View verdict →
• C 49 L-ornithine x Hangover and liver-fatigue improvement
  Small human signals exist for post-hangover and general fatigue, but they are not evidence of improved liver function and lack independent replicat... · View verdict →
• C 48 Lactobacillus-fermented kelp extract x Liver function and liver-marker improvement
  A four-week, 48-person RCT of a specific fermented ingredient found a liver-enzyme signal, but evidence is limited to one manufacturer-linked surro... · View verdict →
• C 45 Korean black raspberry extract powder (individually recognized ingredient No. 2010-62) x Improvement of alcoholic liver-injury markers
  A human application trial of No. 2010-62 at 3,150 mg/day exists, but manufacturer-specific liver-enzyme surrogate evidence without independent repl... · View verdict →
• C 44 Sesamin (sesame lignan) x Lipids and blood pressure, and fatty liver and liver enzymes
  Sesamin-only RCTs show limited lipid and blood-pressure surrogate signals, resulting in C with 44 points, while fatty liver and liver enzymes remai... · View verdict →
• C 43 Tauroursodeoxycholic acid (TUDCA) x Improvement in fatty liver and liver enzymes
  There are data from a pharmaceutical formulation in a specific cholestatic disease and from small metabolic surrogate studies, but no direct fatty-... · View verdict →
• C 42 Licorice glycyrrhizin x Improvement in hepatitis and liver enzymes
  C applies only to the ALT surrogate with intravenous SNMC and does not extend to ordinary oral licorice or antiviral efficacy, resulting in C with... · View verdict →
• C 41 Picrorhiza kurroa (kutki) extract x Improvement in liver function and liver enzymes
  A single 33-person RCT provides a liver-biochemistry signal, but it is old and unreplicated, resulting in C with 41 points. · View verdict →
• C 41 Honeyberry extract powder x Protection from liver injury associated with metabolic abnormalities
  The existence of a human trial is confirmed through regulatory documentation, but publicly verifiable results and independent replication are absen... · View verdict →
• C 40 Calcium D-glucarate x Enhanced liver detoxification and toxin elimination
  The beta-glucuronidase mechanistic surrogate was positive in a Phase I human trial, but actual liver-detoxification and toxin-elimination efficacy... · View verdict →
• D 32 Dandelion (Taraxacum) x Liver, diuretic effect, and digestion
  Human evidence is at the pilot level, and liver, digestion, and detox claims are centered on preclinical evidence and traditional use, so the grade... · View verdict →
• D 25 Chanca piedra (Phyllanthus niruri) x Liver protection and detoxification
  Core liver outcomes were null in two direct RCTs, with only one secondary liver-stiffness signal remaining, resulting in D with 25 points. · View verdict →
• C score not listed Milk thistle (silymarin) x liver health and fatigue improvement
  The evidence is conflicting or limited. · View verdict →
• ? score not listed Dihydromyricetin (DHM) x Hangover prevention and relief
  A purified-DHM RCT exists in NAFLD, but no monotherapy RCT exists for hangover, so the hangover claim remains ?. · View verdict →
• ? score not listed Artemisia capillaris extract x Liver detoxification and hangover improvement
  After separating species, formulations, and multi-herb formulas, no human efficacy literature remains for A. capillaris alone in liver detoxificati... · View verdict →