Antioxidant & Aging

Antioxidant & Aging Evidence Ranking

Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.

• C 56 Grape seed extract (proanthocyanidins/OPC) x Antioxidant, vascular, and edema effects
  Blood pressure shows a small positive signal, but the core antioxidant, vascular, and edema claims rely on surrogate markers and small/industry-fun... · View verdict →
• C 52 Pycnogenol (French maritime pine bark extract) x Antioxidant, vascular, and skin effects
  Human RCTs and meta-analyses exist, but antioxidant, vascular, and skin claims are all centered on short-term surrogate markers, with limits in ind... · View verdict →
• C 52 Sulforaphane/broccoli sprout extract x Antioxidant, detoxification, and anticancer
  There are relatively large human biomarker RCTs, but because they are only surrogate markers, C is the limit. · View verdict →
• C 52 Nicotinamide riboside (NR) x Increased NAD+ and healthy aging
  Blood NAD+ elevation is repeated, but healthspan-related clinical effects are inconsistent, resulting in C with 52 points. · View verdict →
• C 48 Resveratrol x anti-aging and cardiovascular
  Anti-aging lacks human clinical endpoints for lifespan or delayed aging, and the SIRT1 meta-analysis was negative overall. Cardiovascular evidence... · View verdict →
• C 48 Alpha-lipoic acid (ALA, alpha-lipoic acid, thioctic acid) x antioxidant, blood glucose, and nerves
  There are signals for short-term improvement in diabetic nerve symptoms, but long-term neuroprotection and blood-glucose/antioxidant health effects... · View verdict →
• C 43 L-carnosine x Anti-glycation and slowing aging
  A few surrogate anti-glycation signals coexist with later null findings, and there is no clinical aging endpoint, resulting in C with 43 points. · View verdict →
• C 40 Fisetin x Senolytic activity and healthspan extension
  Human senescence-marker evidence is limited and there are no healthspan or lifespan data, resulting in an overall C with 40 points. · View verdict →
• C 40 Ergothioneine x Antioxidant effects and healthy aging
  Absorption and some exploratory cognitive and neuronal-injury signals exist, but antioxidant biomarkers and the primary endpoint of the larger tria... · View verdict →
• C 40 Cycloastragenol (TA-65) x Telomerase activation and telomere maintenance
  An industry-linked signal for a telomere surrogate exists, but dose consistency and functional aging outcomes are absent, resulting in C with 40 po... · View verdict →
• C 40 Cantaloupe melon SOD-gliadin complex (GliSODin) x Antioxidant effects and reduced oxidative stress
  A small positive trial coexists with two null trials in product-specific surrogate evidence, resulting in C with 40 points. · View verdict →
• C 40 Molecular hydrogen-generating tablets x Reduced oxidative stress and anti-aging effects
  Tablet evidence is nearly limited to one 40-person pilot, and the mixed-formulation meta-analysis cannot be attributed to tablets, resulting in C w... · View verdict →
• D 38 Acai berry (Euterpe oleracea) x Antioxidant and anti-aging
  The human data consist only of surrogate markers, and there are no clinical endpoints for anti-aging or health benefits, so the rating is D with 38... · View verdict →
• D 30 Spermidine x Aging, autophagy, and cognition
  The memory signal from the initial 3-month pilot was not reproduced in the N=100, 12-month follow-up trial, and aging and autophagy lack clinical-e... · View verdict →
• D 30 Pterostilbene x Antioxidant effects and healthspan extension
  The direct human antioxidant trial was null and no healthspan evidence exists, resulting in D with 30 points. · View verdict →
• F 10 Vitamin E (high-dose alpha-tocopherol; mainly d-alpha or dl-alpha-tocopherol/acetate, including products of 400 IU or higher) x Antioxidant and cardiovascular health/cardiovascular disease prevention
  High-dose alpha-tocopherol has a plausible antioxidant mechanism, but large RCTs and meta-analyses repeatedly show no benefit on primary cardiovasc... · View verdict →
• D score not listed NMN (nicotinamide mononucleotide) x anti-aging and NAD+ increase
  Human evidence is insufficient or was not confirmed in key trials · View verdict →
• ? score not listed Calcium alpha-ketoglutarate (Ca-AKG) x Reduction in biological age and lifespan extension
  Human efficacy results for Ca-AKG alone are absent, so the biological-age and lifespan claims remain ungraded. · View verdict →
• ? score not listed Luteolin x Senolytic action and inhibition of neurological aging
  No direct human efficacy trial was identified, so the grade is ? and there is no score. · View verdict →