Lactiplantibacillus plantarum HAC01,
does it really help with Reduced postprandial glucose rise in adults with prediabetes?
research showsHAC01 lowered two-hour postprandial glucose and HbA1c in an eight-week RCT of 40 adults with impaired glucose tolerance, but fasting glucose, insulin, and HOMA-IR were not significant. One strain, one trial, and surrogate endpoints support C with 54 points.
ads claimMarketing can frame it as a 'blood-sugar probiotic,' a 'diabetes probiotic,' or a single solution for both gut and glucose health. The evidence is limited to short-term laboratory values in a subgroup with prediabetes, not diabetes treatment, medication replacement, or complication prevention.
Useful facts when choosing a product
- The Korean individually recognized ingredient number is 2022-21, with a recognized intake of HAC01 at 4×10^9 CFU/day.
- The pivotal RCT used the same 4×10^9 CFU/day in one daily capsule.
- Korean combination products for glucose and gut health are marketed, but evidence for other probiotics or added ingredients must be separated from the HAC01 glucose evidence.
- The Korean regulator advises consultation or caution for people with disease or medication use, allergic conditions or short-bowel syndrome, infants and children, and pregnancy or lactation.
What the research actually shows
The Oh 2021 RCT randomized 40 adults with impaired glucose tolerance to HAC01 at 4×10^9 CFU/day or placebo for eight weeks. Compared with placebo, HAC01 significantly reduced two-hour glucose during a 75 g oral glucose-tolerance test and HbA1c, while fasting glucose, insulin, HOMA-IR, QUICKI, microbiota composition, and fecal short-chain fatty acids were not significant. The trial received government research funding, but no independent replication of HAC01 efficacy in humans was identified.
Why this is classified as C (54)
A positive RCT with a prespecified postprandial endpoint exists, but it is an eight-week, 40-person, single-strain, single-trial surrogate study, supporting C with 54 points.
Counterpoint. A human signal for two-hour glucose in adults with prediabetes remains. The judgment applies only to HAC01 at a matching dose and does not extend to diabetes treatment or the entire L. plantarum species.
Rejudgment record. New verdict — Positive postprandial-glucose and HbA1c surrogates in one eight-week, 40-person strain-specific RCT, but null fasting glucose and insulin markers and no independent replication
Cross-check — Codex and Claude
Evidence Table
| Study | Design | Sample | Funding | Endpoint | Result | Weight |
|---|---|---|---|---|---|---|
| Oh MR et al. 2021 | Randomized double-blind placebo-controlled trial | 40 | National Research Foundation of Korea and government grant | Two-hour glucose during a 75 g OGTT, HbA1c, fasting glucose, and insulin | Two-hour glucose and HbA1c improved, while fasting glucose, insulin, HOMA-IR, and QUICKI were not significant. | Key |
| MFDS individually recognized ingredient 2022-21 | Regulatory ingredient information | Not applicable | Recognized function, intake, and precautions | Registered for helping suppress the postprandial glucose rise at 4×10^9 CFU/day. | Product information |
Receipt — 2 References
All 2 cited sources were verified for existence at the original page (as of 2026-07-17).
Reviewed and approved: Chamgap Editorial Team · Approval date: 2026-07-17 · Corrections: none
Cite this verdict
[Chamgap] Lactiplantibacillus plantarum HAC01 x reduced postprandial glucose rise in adults with prediabetes — Evidence Grade C·54. 2 cited sources checked. Source: https://chamgap.com/en/verdicts/blood-sugar/lactiplantibacillus-plantarum-hac01-postprandial-glucose/ · CC BY 4.0CC BY 4.0 — free to use with attribution; do not distort grades, numbers, or verdict meaning.
What this document does and does not do
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