Verdict No. 3030 · Search date 2026-09-08 · Methodology v1.0
Oral whole Nigella sativa seed powder capsules,
does it really help with Improvement in TSH and anti-TPO in Hashimoto thyroiditis?
30-Second Summary
C
Evidence Grade C · 54 · Safety caution
T3, T4, weight, VEGF, and Nesfatin-1 are secondary or mechanistic outcomes, not the principal claim.
Composition varies by product and extraction method. People who are pregnant or breastfeeding, children, those with liver or kidney disease, and anyone using glucose-, blood-pressure-, anticoagulant-, antiseizure-, or immune-modifying medicines should seek clinical advice. Small trials cannot exclude rare or long-term harms.
What the
research showsGrade C with 54 points. TSH and anti-TPO were lower than placebo after eight weeks in 40 completers, but this was one small completer analysis and did not establish symptom relief, medication withdrawal, or durable thyroid function.
research showsGrade C with 54 points. TSH and anti-TPO were lower than placebo after eight weeks in 40 completers, but this was one small completer analysis and did not establish symptom relief, medication withdrawal, or durable thyroid function.
What the
ads claimStopping medication or curing autoimmune thyroiditis was not tested.
ads claimStopping medication or curing autoimmune thyroiditis was not tested.
Useful facts when choosing a product
- This verdict applies only to the exact plant part, formulation, route, dose, population, endpoint, and comparator shown above.
- Seed powder, fixed oil, aqueous extract, ethanolic topical preparation, purified thymoquinone, and combinations are not interchangeable.
- Composition varies by product and extraction method. People who are pregnant or breastfeeding, children, those with liver or kidney disease, and anyone using glucose-, blood-pressure-, anticoagulant-, antiseizure-, or immune-modifying medicines should seek clinical advice. Small trials cannot exclude rare or long-term harms.
Chamgap Semantic Classification Code
Permanent code issued
S.nigella-sativa.oral.hashimoto-thyroid-markers.improve.placeboSupplements and nutraceuticals > Nigella sativa > Oral > Hashimoto thyroid markers > Improvement claim > Placebo
Issued for TSH and anti-TPO markers on stable levothyroxine, separate from symptoms, drug withdrawal, and cure. The code identifies the intervention and claim; it never contains the evidence grade, score, or safety result.
Exact Claim Classification
These independent facets prevent evidence from different forms, routes, populations, effects, and comparators from being mixed.
| Intervention class | S · Supplement or nutraceutical |
|---|---|
| Canonical ingredient or intervention | Nigella sativa |
| Source or part used | Whole Nigella sativa L. seed |
| Formulation or processing | Ground whole-seed powder in 1-g capsules |
| Route | Oral |
| Dose | 1 g before lunch and dinner, 2 g/day total |
| Duration | Eight weeks of treatment and follow-up |
| Population | Adults with Hashimoto thyroiditis on stable levothyroxine |
| Effect or condition | Improved TSH and anti-TPO laboratory markers |
| Primary endpoint | Eight-week TSH; anti-TPO reported as a related thyroid marker |
| Comparator | Starch placebo added to common therapy |
| Duplicate-detection key | nigella-sativa|whole-seed-powder-capsule|oral|adult-hashimoto-stable-levothyroxine|tsh-antitpo-improvement|8-weeks |
Gap Measurement · Verdict 3030 · C 54
What the research actually shows
Two grams per day of seed powder were added while stable levothyroxine continued.
Why this is classified as C (54)
An independent registered trial and positive laboratory signal are strengths, but surrogate endpoints, 40 completers, eight weeks, and a single study yield C with 54 points.
Counterpoint. Uncertainty does not prove no effect, but a signal from one formulation cannot validate another formulation or claim.
Rejudgment record. Independent Codex cross-check — One page, one route, one population, one claim, one principal comparator
Scoring profile behind this grade
| Endpoint | S | Surrogate marker - laboratory or imaging measures |
| Replication | R1 | Single confirmatory trial |
| Independence | I2 | Decisive evidence is publicly or non-profit funded |
| Effect size | E+ | Meets the clinically important threshold |
| Precision | C0 | The confidence interval leaves room for benefit |
The scoring table and the verdict agree (C).
Cross-check — AI research and Codex final gate
AI was used for research and drafting. Blind grading, adversarial audit, and the methodology boundary rules were then reapplied before Codex performed the final evidence, grade, copy, and build checks. If a grade cannot be narrowed, both evidence positions and their reasons are published.
Evidence Table
| Study | Design | Sample | Funding | Endpoint | Result | Weight |
|---|---|---|---|---|---|---|
| The effects of Nigella sativa on thyroid function, serum VEGF-1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis | The cited controlled design and its allocation or masking limitations were independently checked. | 40 | Funding, product support, and employee authorship were assessed separately; unverified items were not counted as strengths. | The principal endpoint is defined in the exact facets; secondary outcomes remain separate. | The verified quantitative result is reported in the English reader answer and rationale without inventing missing confidence intervals. | Direct small surrogate-outcome trial |
Receipt — 1 References
All 1 cited sources were verified for existence at the original page (as of 2026-09-08).
Farhangi MA et al. Nigella sativa in Hashimoto thyroiditis. BMC Complement Altern Med. 2016. PMID: 27852303. PMCID: PMC5112739. DOI: 10.1186/s12906-016-1432-2. IRCT2015021719082N4.
checkedResearch and draft: AI used · Cross-check: blind grading and adversarial audit
Final verification and publication gate: Codex · Verification cutoff: 2026-09-08 · Corrections: none
Final verification and publication gate: Codex · Verification cutoff: 2026-09-08 · Corrections: none
Cite this verdict
[Chamgap] Nigella Seed Powder for Hashimoto Thyroiditis—An Eight-Week Laboratory Signal, Not Evidence of Cure — Evidence Grade C·54. 1 cited sources checked. Source: https://chamgap.com/en/verdicts/general/oral-nigella-seed-powder-hashimoto-thyroid-markers/ · CC BY 4.0CC BY 4.0 — free to use with attribution; do not distort grades, numbers, or verdict meaning.
What this document does and does not do
Chamgap is an information source. It reports what research has and has not confirmed; it does not tell readers what to take or buy. That decision belongs to readers and, when needed, medical or legal professionals. This verdict reflects literature available up to the search date and may change as new research appears. Nothing here is medical advice.