Oral Nigella sativa seed capsules,
does it really help with Increased complete clearance or expulsion of adult kidney stones?
research showsGrade C with 56 points. Complete clearance was approximately 12/27 (44.4%) versus 4/26 (15.3%) in a triple-blind trial. A Codex reconstruction gives RR 2.89 (95% CI 1.07-7.82), but events were few and replication is needed.
ads claimThe trial does not establish replacement of procedures or standard care for every stone size, composition, and location.
Useful facts when choosing a product
- This verdict applies only to the exact plant part, formulation, route, dose, population, endpoint, and comparator shown above.
- Seed powder, fixed oil, aqueous extract, ethanolic topical preparation, purified thymoquinone, and combinations are not interchangeable.
- Composition varies by product and extraction method. People who are pregnant or breastfeeding, children, those with liver or kidney disease, and anyone using glucose-, blood-pressure-, anticoagulant-, antiseizure-, or immune-modifying medicines should seek clinical advice. Small trials cannot exclude rare or long-term harms.
Chamgap Semantic Classification Code
Permanent code issued
S.nigella-sativa.oral.kidney-stone-clearance.increase.placeboSupplements and nutraceuticals > Nigella sativa > Oral > Complete kidney-stone clearance > Increase claim > Placebo
Issued for complete ultrasound clearance; size reduction remains a separate endpoint. The code identifies the intervention and claim; it never contains the evidence grade, score, or safety result.
Exact Claim Classification
These independent facets prevent evidence from different forms, routes, populations, effects, and comparators from being mixed.
| Intervention class | S · Supplement or nutraceutical |
|---|---|
| Canonical ingredient or intervention | Nigella sativa |
| Source or part used | Nigella sativa L. seed |
| Formulation or processing | 500-mg ground-seed capsules |
| Route | Oral |
| Dose | 500 mg twice daily |
| Duration | Ten weeks of treatment and ultrasound follow-up |
| Population | Adults with kidney stones |
| Effect or condition | Increased complete stone clearance or expulsion |
| Primary endpoint | Complete disappearance of stones on ultrasound |
| Comparator | Matched placebo |
| Duplicate-detection key | nigella-sativa|ground-seed-capsule|oral|adults-kidney-stones|complete-clearance|10-weeks |
What the research actually shows
Ground-seed capsules were compared with placebo for ten weeks and stones were assessed by ultrasound.
Why this is classified as C (56)
A clinical clearance event, independent study, and positive contrast are strengths, but one small sample, reconstructed denominators, and imaging limitations yield C with 56 points.
Counterpoint. Uncertainty does not prove no effect, but a signal from one formulation cannot validate another formulation or claim.
Rejudgment record. Independent Codex cross-check — One page, one route, one population, one claim, one principal comparator
| Endpoint | H | Hard endpoint - actual events such as death |
| Replication | R1 | Single confirmatory trial |
| Independence | I2 | Decisive evidence is publicly or non-profit funded |
| Effect size | E+ | Meets the clinically important threshold |
| Precision | C0 | The confidence interval leaves room for benefit |
The scoring table and the verdict agree (C).
Cross-check — AI research and Codex final gate
Evidence Table
| Study | Design | Sample | Funding | Endpoint | Result | Weight |
|---|---|---|---|---|---|---|
| Efficacy of black seed (Nigella sativa L.) on kidney stone dissolution | The cited controlled design and its allocation or masking limitations were independently checked. | 26 | Funding, product support, and employee authorship were assessed separately; unverified items were not counted as strengths. | The principal endpoint is defined in the exact facets; secondary outcomes remain separate. | The verified quantitative result is reported in the English reader answer and rationale without inventing missing confidence intervals. | Direct event signal; reconstructed counts |
Receipt — 1 References
All 1 cited sources were verified for existence at the original page (as of 2026-09-08).
Final verification and publication gate: Codex · Verification cutoff: 2026-09-08 · Corrections: none
Cite this verdict
[Chamgap] Nigella Seed Capsules for Kidney Stones—A Ten-Week Clearance Signal With Few Events — Evidence Grade C·56. 1 cited sources checked. Source: https://chamgap.com/en/verdicts/general/oral-nigella-seed-capsules-kidney-stone-clearance/ · CC BY 4.0CC BY 4.0 — free to use with attribution; do not distort grades, numbers, or verdict meaning.
What this document does and does not do
Chamgap is an information source. It reports what research has and has not confirmed; it does not tell readers what to take or buy. That decision belongs to readers and, when needed, medical or legal professionals. This verdict reflects literature available up to the search date and may change as new research appears. Nothing here is medical advice.