Winter cod liver oil × Reduced other acute respiratory infections

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionSelected ARI question and original gradeRequired	The selected subclaim is reduced other acute respiratory infections, grade D, with a note that both indicators were null. Subclaim score/status/axes are absent; parent D with 34 points is not used to fill the subclaim score. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Subclaim score/status/axes are absent; PCR/serious results are not transferred to the same ARI outcome. Existing content review remains incomplete.	Existing question/grade/note versus the parent coprimary verdict	Proposed follow-up comparative research specifying the ARI question/indicators; no new investigation, calculation or trial was performed in this production.
2	Partly verified	Full text not readStored summary read	N02 · Evidence conditionNorwegian adults and routine supplementationRequired	This was a winter trial in Norwegian adults not routinely taking vitamin D daily. Do not extend the effect to every population/season or those taking daily supplements. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Age/baseline conditions, eligibility/recruitment, diet/baseline supplement amounts and balance by population remain unverified. Existing content review remains incomplete.	Actual population, eligibility, routine vitamin D exposure and season	Proposed follow-up research specifying population and prior exposure; no new investigation, calculation or trial was performed in this production.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionBaseline vitamin D status and treatment scopeRequired	Not taking daily vitamin D supplements is not converted to confirmed normal vitamin D or deficiency. The original verdict records that deficiency treatment is outside scope. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Baseline vitamin D measurements/distribution, deficiency diagnoses and status-specific analyses remain unverified. Existing content review remains incomplete.	Supplement habits versus deficiency diagnosis/baseline status	Proposed research separating baseline status from the selected combination-product scope; no new investigation, calculation or trial was performed in this production.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionCombination-study product identityRequired	Cod liver oil 5 mL/day supplied vitamin D 10 µg and about 1 g n-3 fatty acids. The combination result is not transferred to vitamin D/omega-3 alone or high-dose treatment; no new dose conversion is made. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Product/batches, full ingredient/specification details and direct single-ingredient effects remain unverified. Existing content review remains incomplete.	Cod-liver-oil product/combination ingredients versus single-ingredient attribution	Proposed follow-up research separating the same combination product from ingredient attribution; no new investigation, calculation or trial was performed in this production.
5	Partly verified	Full text not readStored summary read	N05 · Evidence conditionFlavour-matched corn-oil placeboRequired	The comparator was flavour-matched corn-oil placebo. The name does not establish matching of every ingredient/sensory/contact feature or absence of biological placebo effects. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Placebo composition/specifications, maintained masking, contact/instructions and other exposure differences remain unverified. Existing content review remains incomplete.	Actual placebo, ingredients/sensory features and contact comparison	Proposed follow-up trial disclosing actual comparison conditions; no new investigation, calculation or trial was performed in this production.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionWinter and a median 164 daysRequired	Original median 164 days of use and about six winter months are preserved. Do not turn this into identical exact duration/complete intake for everyone or a sustained year-round effect. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Individual durations, start/end/assessment windows, actual exposure/discontinuation and follow-up periods remain unverified. Existing content review remains incomplete.	Duration/median versus individual exposure/observation windows	Proposed follow-up research separating planned/actual duration and season; no new investigation, calculation or trial was performed in this production.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionIndependent allocation department and concealmentRequired	The original text records randomization by Oslo University Hospital’s research-support department without investigator involvement. This is not upgraded to current allocation/concealment verification. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Sequence/concealment, implementation/exceptions, baseline balance and original protocol remain unread. Existing content review remains incomplete.	Historical randomization procedures versus actual original-text access	Proposed follow-up trial disclosing allocation procedures; no new investigation, calculation or trial was performed in this production.
8	Partly verified	Full text not readStored summary read	N08 · Evidence conditionQuadruple masking and each roleRequired	The original text records quadruple masking and masking of several roles to assignment. Historical descriptions do not establish current verification of maintenance/unmasking or expectation effects on self-reports. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Original masking success/maintenance, unmasking, measurement/analysis roles and expectation effects remain unread. Existing content review remains incomplete.	Masking of participants, researchers/care and data/assessment/analysis personnel	Proposed follow-up research specifying masking and self-reported measurement; no new investigation, calculation or trial was performed in this production.
9	Partly verified	Full text not readStored summary read	N09 · Evidence conditionSelf-reported ARI definitionRequired	One selected indicator is self-reported acute respiratory infection. It is not converted to test/clinician-confirmed other-pathogen infection, PCR COVID-19 or serious outcomes. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Symptom/question definitions, recall/report windows, medical/test confirmation and first/repeated-event handling remain unverified. Existing content review remains incomplete.	Self-report, symptoms, diagnostic confirmation and first/repeated infections	Proposed follow-up research separating self-reports from confirmed infections; no new investigation, calculation or trial was performed in this production.
10	Partly verified	Full text not readStored summary read	N10 · Evidence conditionSelf-reported ARI counts and RRRequired	Original self-reported ARI was 3,964 versus 3,834, RR 1.04 (0.97–1.11). No new proportions/absolute differences/CI or symptom-day/event totals are calculated. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Whether counts concern people/first/repeated events, effective denominators, adjustments/models and exact P values remain unverified. Existing content review remains incomplete.	Original counts/effects/CI and exact units/denominators	Proposed research disclosing units/denominators together with effects; no new investigation, calculation or trial was performed in this production.
11	Partly verified	Full text not readStored summary read	N11 · Evidence conditionNegative SARS-CoV-2 test indicatorRequired	Negative SARS-CoV-2 tests were a separate coprimary indicator: 8,546 versus 8,565, RR 1.00 (0.97–1.04). They are not treated as other-pathogen diagnoses or the same outcome as self-reported ARI. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Testing populations/reasons, units/repetition, test types, accompanying symptoms and other-pathogen confirmation remain unverified. Existing content review remains incomplete.	Negative tests versus ARI/other-pathogen confirmation	Proposed follow-up research separating negative tests from actual ARI confirmation; no new investigation, calculation or trial was performed in this production.
12	Unverified	Full text not readStored summary read	N12 · Evidence conditionTesting selection and confirmed-ARI gapsRequired	Original materials record negative tests and self-reported ARI separately. The indicators are not combined into new clinician/pathogen-confirmed ARI counts. S01	Required current information remains unverified in the preserved summary. Testing/reporting flow, symptom/test timing, sensitivity/adjudication and separate confirmed non-COVID ARI results remain unverified. Existing content review remains incomplete.	Self-report/testing and confirmed/unconfirmed infection scope	Proposed research separating self-report/testing selection from confirmed results; no new investigation, calculation or trial was performed in this production.
13	Partly verified	Full text not readStored summary read	N13 · Evidence conditionPCR COVID-19 is a related outcomeRequired	Original PCR infection was 227 versus 228, RR 1.00 (adjusted 95% CI 0.82–1.22). This is not transferred to events/effects for self-reported ARI or negative tests. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Specific PCR tests/denominators/models and ARI overlap/exclusion remain unverified. Existing content review remains incomplete.	PCR-confirmed COVID-19 versus other ARI endpoints	Proposed follow-up research reporting related endpoints separately; no new investigation, calculation or trial was performed in this production.
14	Partly verified	Full text not readStored summary read	N14 · Evidence conditionSerious COVID-19 is a related outcomeRequired	Original serious COVID-19 was 121 versus 101, RR 1.20 (0.87–1.65). Do not combine this as selected ARI severity/effects or all infection events. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Serious components/adjudication, effective denominators, overlap/models and selected ARI severity remain unverified. Existing content review remains incomplete.	Serious-outcome definitions/events/ratios versus other ARI	Proposed follow-up research separating endpoint components/overlap; no new investigation, calculation or trial was performed in this production.
15	Partly verified	Full text not readStored summary read	N15 · Evidence conditionFour coprimary outcomes and fallbackRequired	Original descriptions of four coprimary endpoints, prespecified fallback multiplicity control and all-null findings are preserved. Each indicator is not turned into an independent trial or new success/exactly-zero-effect verdict for a single subclaim. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Fallback rules/order, full adjustment/testing specifications and SAP/amendments remain unread. Existing content review remains incomplete.	Coprimary outcomes/multiplicity, adjusted CI and prespecified hierarchy	Proposed follow-up research specifying coprimary outcomes and adjusted results; no new investigation, calculation or trial was performed in this production.
16	Partly verified	Full text not readStored summary read	N16 · Evidence condition34,601·17,278/17,323Required	Original randomization of 34,601 adults and arm sizes 17,278/17,323 are preserved. They are not automatically filled in as every indicator’s observation/person/event denominator. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Indicator-specific effective/observed/at-risk denominators, repeated tests/reports and unobserved-data definitions remain unverified. Existing content review remains incomplete.	Randomized population versus indicator-specific observations/denominators	Proposed follow-up research distinguishing recruitment/observation/analysis denominators; no new investigation, calculation or trial was performed in this production.
17	Partly verified	Full text not readStored summary read	N17 · Evidence conditionITT and 0.05% key-variable missingnessRequired	Original ITT for all randomized participants and 0.05% key-variable missingness are preserved. They do not verify no missingness or complete observation for every questionnaire/test/symptom-day outcome. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Variable/arm/period-specific missingness, handling/models, follow-up/sensitivity and actual original text remain unread. Existing content review remains incomplete.	Analysis by assignment and variable-specific missingness/handling scope	Proposed research reporting differences between variable-specific observation and ITT estimation; no new investigation, calculation or trial was performed in this production.
18	Partly verified	Full text not readStored summary read	N18 · Evidence conditionPeople, symptom days, repetitions and testsRequired	The four original counts/indicators are preserved separately. People, infection episodes, symptom days, tests and related sheets are not counted as new participant/event/independent-trial totals. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. First/all/repeated-event definitions, symptom days, individual overlap and period-specific observation/time remain unverified. Existing content review remains incomplete.	Outcome units and repetition/time overlap handling	Proposed research separately reporting people/events/days/test units; no new investigation, calculation or trial was performed in this production.
19	Partly verified	Full text not readStored summary read	N19 · Evidence conditionActual intake and concurrent exposuresRequired	5 mL/day and a median 164 days describe study exposure/duration. Actual complete intake or matching of concurrent vitamins/medications and lifestyle/prevention/testing conditions are not confirmed. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Adherence/discontinuation, additional supplements/medications, lifestyle/prevention, testing/contact and their analyses remain unverified. Existing content review remains incomplete.	Original exposure/duration versus adherence, vitamins and behaviour/testing differences	Proposed follow-up research specifying actual exposure and concurrent conditions; no new investigation, calculation or trial was performed in this production.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionBetween-arm RR/CI and the scope of null findingsRequired	Original ARI-related RRs/CI are retained. Within-arm symptom changes, RR near 1.00 or nonsignificance do not newly establish exactly zero effect, equivalence or absence of benefit/harm in every population. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Exact contrasts/models, adjustments, P, importance/equivalence criteria and indicator-specific estimation specifications remain unread. Existing content review remains incomplete.	Original relative effects/adjusted CI, within/between-arm and zero/equivalence distinctions	Proposed follow-up research reporting effects/precision and applicability; no new investigation, calculation or trial was performed in this production.
21	Partly verified	Full text not readStored summary read	N21 · Evidence conditionNCT, prespecified dates and original plansRequired	Original NCT04609423, posted 2020-10-30 and started 2020-11-10, are retained. Prospective/matching-coprimary descriptions are not upgraded to current full registration/plan verification. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Registration amendments, protocol/SAP and full indicator definition/testing/plans remain unread. Existing content review remains incomplete.	Registration identifier/dates and preserved prespecified coprimary scope	Proposed research linking and disclosing prespecified coprimary outcomes and actual analysis; no new investigation, calculation or trial was performed in this production.
22	Partly verified	Full text not readStored summary read	N22 · Evidence conditionManufacturer funding and products/placeboRequired	Möller’s Tran manufacturer Orkla Health AS supplied funding, cod liver oil and placebo. Original context of a large null report for its own product is retained; funding alone does not yield a new independence/effect verdict. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Contracts, design/analysis/data/publication authority, original support text and full product/batch details remain unread. Existing content review remains incomplete.	Orkla support items/roles and product identity	Proposed follow-up trial disclosing support/research roles; no new investigation, calculation or trial was performed in this production.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionUniversity/hospital and other supportRequired	Original Oslo University Hospital/University of Oslo support is retained. Public/university support does not replace manufacturer support or establish absence of all other support/COI. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Cash/in-kind support, institutional roles, external analysis/medical writing/publication costs and full support disclosures remain unread. Existing content review remains incomplete.	Oslo institutional support and item-specific roles	Proposed research separately disclosing support items and roles; no new investigation, calculation or trial was performed in this production.
24	Partly verified	Full text not readStored summary read	N24 · Evidence conditionOutside relationships and employee authorsRequired	Original KBH relationships with Olympic Seafood/Amgen/Sanofi, SMU with Olympic Seafood outside this study, and AS/KTK employment at Age Laboratories AS are retained. They are not converted to the same relationship as trial funding/product supply. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Relationships/contributions, contemporaneous contracts, diagnostic/analysis/data/publication roles and full COI disclosures remain unread. Existing content review remains incomplete.	KBH/SMU outside relationships and AS/KTK affiliation scope	Proposed research distinguishing and disclosing relationships inside/outside the study and roles; no new investigation, calculation or trial was performed in this production.
25	Partly verified	Full text not readStored summary read	N25 · Evidence conditionOne trial, four indicators and related sheetsRequired	S01 Brunvoll 2022 concerns the same trial of 34,601 adults. Four coprimary indicators, people/tests/time points, citations/registration and related sheets are not added as new independent trials/participants. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Independent replication matching formulation/population/ARI specifications and unique clinical totals are not established. Existing content review remains incomplete.	Report→cohort→indicator/time links and independent replication	Proposal for later independent comparative research on the same selected question; no new investigation, calculation or trial was performed in that production.
26	Partly verified	Full text not readStored summary read	N26 · Evidence conditionDeficiency, high dose, ingredients and long-term scopeRequired	The original verdict does not address deficiency treatment, high-dose vitamin D or omega-3 alone. A null combination product is not transferred to direct verdicts for those conditions/other seasons/long-term outcomes or to intake/treatment guidance. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Direct comparisons for other formulations/exposures/populations, persistence afterwards and clinical outcomes remain unverified. Existing content review remains incomplete.	Winter combination product versus other ingredient/treatment/duration applications	Proposed research distinguishing combination product from other application specifications; no new investigation, calculation or trial was performed in this production.
27	Partly verified	Full text not readStored summary read	N27 · Harm-information gaps supplementing the efficacy tableOriginal safety record and low-grade reportingSupplementary	Original parent good safety and low-grade side effects in both arms are retained. Scope is limited to tested dose/participants; rare/long-term harms or other-product safety are not verified. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Types/frequencies/denominators, collection/adjudication, discontinuation/causality and long-term/vulnerable-population harms remain unverified. Existing content review remains incomplete.	Low-grade side effects, arm-specific frequencies/denominators and long-term harms	Proposed research specifying harm collection/scope and follow-up; no new investigation, calculation or trial was performed in this production.
28	Partly verified	Full text not readStored summary read	N28 · Evidence conditionOriginal axes, bilingual text, dates and historyRequired	Parent D with 34 points, B/H/R1/I0/E0/B0/C0, true large-hard-endpoint-RCT and two false indicators, empty override reasons and subclaim D/note are preserved. Bilingual text, 2026-08-26, empty corrections/deliberation and cross-checking are not inherited as completed clinical review now or subclaim scores. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Absent subclaim score/status/axes are not filled with parent values; no new coprimary/method certification. Existing content review remains incomplete.	Original parent/subclaim values, axes, corrections and historical verification	Proposed research distinguishing original values/history from new-update scope; no new investigation, calculation or trial was performed in this production.
29	Partly verified	Full text not readStored summary read	N29 · Evidence conditionActual summary reading, links and gapsRequired	The full preserved summary/citations were used for production and links retained. Original papers/registration/protocol/SAP/support/COI materials remain unread, access unattempted and external links untested. S01	Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. External original content, exact definitions/denominators/models and accessibility remain unverified. Existing content review remains incomplete.	Reading preserved summaries versus external text/registration/plan access	Proposal for updating while distinguishing actual acquisition/timing/scope; no new investigation, calculation or trial was performed in that production.

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29 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-08-26
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: Winter trial in Norwegian adults not taking vitamin D supplements daily. Original randomized denominators: 34,601 adults, 17,278/17,323. Detailed eligibility, baseline vitamin D/conditions, indicator-specific observations/denominators and missingness/withdrawals remain unverified.
Ingredient, formulation and route: Combination cod-liver-oil study product 5 mL/day supplied vitamin D 10 µg and about 1 g n-3 fatty acids. It is not repurposed as single-ingredient, deficiency-treatment or high-dose vitamin D effects; no new intake/prevention/treatment instructions or dose conversion.
Dose: Original 5 mL/day, median 164 days of use and about six winter months are preserved separately. Identical/complete exposure in every participant, daily adherence/discontinuation and follow-up windows remain unverified; no new duration/exposure conversion.
Comparator: Quadruple-blinded randomized comparison with flavour-matched corn-oil placebo. Independent-department allocation, role-specific masking, all-randomized ITT and 0.05% key-variable missingness are preserved historical descriptions, not current procedural/original-text verification. Actual sensory matching, concurrent exposures and variable-specific missingness/observation remain unverified.
Measured outcome: Two selected other-ARI-related indicators: negative SARS-CoV-2 tests, 8,546 versus 8,565, RR 1.00 (0.97–1.04), and self-reported ARI, 3,964 versus 3,834, RR 1.04 (0.97–1.11). Negative tests are not converted to other-pathogen/clinician-confirmed ARI. PCR infection 227/228, RR 1.00 (0.82–1.22), and serious outcomes 121/101, RR 1.20 (0.87–1.65), remain separate related outcomes. Original four-coprimary/fallback/adjusted-CI descriptions are preserved; no new people/event/test/symptom-day totals, proportions/effects/CI.
Duration: Winter use for a median 164 days/about six months. Actual individual observations/tests/reports/discontinuation, repetitions/symptom days and later/other-season effects remain unverified.
Questions outside this scope: Converting negative SARS tests to the same infection endpoint as other-pathogen/clinician-confirmed ARI or self-reported ARI; Repurposing PCR/serious counts, RR or CI as selected ARI events/effects; Combining four indicators/tests/symptom days/repeated counts into new people/events/period effects; Converting no baseline daily supplements to confirmed normal/deficient status or repurposing combination 5 mL/vitamin D 10 µg/about 1 g n-3 as high-dose/deficiency-treatment/single-ingredient effects; Treating ITT/0.05% key-variable missingness as complete observation or identical denominators for all variables/indicators; Converting original RR/adjusted CI/fallback/null findings into new exactly-zero-effect/equivalence/all-population-null certification; Summing people/groups/tests/events/timepoints/bibliographies, registrations or sibling sheets as new independent trials/participants; Inheriting original parent values/axes or historical verification/registration/allocation/masking/analysis wording as subclaim scores or current content review/full-text reading; New calculations, invented quantities, effects/CI, grades/independence certification or cod-liver-oil/vitamin/product-use/testing/infection-prevention/respiratory-management/treatment-replacement instructions

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

S01 · Brunvoll SH et al. 2022

PubMed

Material type: Quadruple-blinded randomized placebo-controlled trial
Materials actually read: Summary read; external material unread
Findings recorded in the stored summary: 227 vs 228, RR 1.00 (0.82–1.22); 121 vs 101, RR 1.20 (0.87–1.65); 8,546 vs 8,565, RR 1.00 (0.97–1.04); 3,964 vs 3,834, RR 1.04 (0.97–1.11)
Record level: Outcome wording in the stored summary
Study overlap and independent replication: S01 Brunvoll 2022 reports a quadruple-blinded winter trial in 34,601 Norwegian adults (17,278/17,323) not routinely taking vitamin D daily, comparing cod liver oil 5 mL/day with flavour-matched corn oil. Median 164 days/about six months, four coprimary outcomes/fallback/ITT and 0.05% key-variable missingness are original descriptions. Selected ARI-related negative tests 8,546/8,565, RR 1.00 (0.97–1.04), are distinguished from self-reports 3,964/3,834, RR 1.04 (0.97–1.11); negative tests are not converted to other-pathogen/clinician-confirmed infection. PCR 227/228, RR 1.00 (0.82–1.22), and serious outcomes 121/101, RR 1.20 (0.87–1.65), remain separate related endpoints. Combination-product vitamin D 10 µg/about 1 g n-3 is not repurposed as single-ingredient/deficiency-treatment/high-dose effects. People, arms, tests, events, time points, citations/registration and related sheets are not added as new independent trials/participants. Report-item counts are not unique clinical totals; no new calculations, independence certification or implementation guidance.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored summary	Stored file	Stored summary	Summary read	Only stored-summary and bibliographic content was used for production. External material verification/review is not complete.
External paper	Public availability unverified; only bibliography links preserved	Unread; access not attempted	Not read	No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status.
Registration material	Public availability unverified; only bibliography links preserved	Unread; access not attempted	Not read	No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status.
Protocol	Public availability unverified; only bibliography links preserved	Unread; access not attempted	Not read	No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status.
Statistical analysis plan	Public availability unverified; only bibliography links preserved	Unread; access not attempted	Not read	No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status.
Funding, product-support and COI material	Public availability unverified; only bibliography links preserved	Unread; access not attempted	Not read	No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status.

Report counts versus independent study counts

S01 Brunvoll 2022 reports a quadruple-blinded winter trial in 34,601 Norwegian adults (17,278/17,323) not routinely taking vitamin D daily, comparing cod liver oil 5 mL/day with flavour-matched corn oil. Median 164 days/about six months, four coprimary outcomes/fallback/ITT and 0.05% key-variable missingness are original descriptions. Selected ARI-related negative tests 8,546/8,565, RR 1.00 (0.97–1.04), are distinguished from self-reports 3,964/3,834, RR 1.04 (0.97–1.11); negative tests are not converted to other-pathogen/clinician-confirmed infection. PCR 227/228, RR 1.00 (0.82–1.22), and serious outcomes 121/101, RR 1.20 (0.87–1.65), remain separate related endpoints. Combination-product vitamin D 10 µg/about 1 g n-3 is not repurposed as single-ingredient/deficiency-treatment/high-dose effects. People, arms, tests, events, time points, citations/registration and related sheets are not added as new independent trials/participants. Report-item counts are not unique clinical totals; no new calculations, independence certification or implementation guidance.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Selected ARI question and original grade

Required materials and conditions: Existing question/grade/note versus the parent coprimary verdict
Conditions for verification: Relevant originals and analysis scope for Existing question/grade/note versus the parent coprimary verdict should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Existing question/grade/note versus the parent coprimary verdict to connect materials needed for the selected question with available materials.
Referenced methods: M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are custom design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is custom design; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design

N02 · Norwegian adults and routine supplementation

Required materials and conditions: Actual population, eligibility, routine vitamin D exposure and season
Conditions for verification: Relevant originals and analysis scope for Actual population, eligibility, routine vitamin D exposure and season should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Actual population, eligibility, routine vitamin D exposure and season to connect materials needed for the selected question with available materials.
Referenced methods: M03 §3.2.1; Detailed population conditions are Chamgap design; M03 §3.2.1–3.2.4; Dose, duration and effect-modifier details are Chamgap design

N03 · Baseline vitamin D status and treatment scope

Required materials and conditions: Supplement habits versus deficiency diagnosis/baseline status
Conditions for verification: Relevant originals and analysis scope for Supplement habits versus deficiency diagnosis/baseline status should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Supplement habits versus deficiency diagnosis/baseline status to connect materials needed for the selected question with available materials.
Referenced methods: M03 §3.2.1; Detailed population criteria are designed by CHAMGAP; M03 §3.2.1–3.2.4; Dose, duration and effect-modification details are designed by CHAMGAP; M03 §3.2.2–3.2.3; Reverse labels and test adaptations are designed by CHAMGAP

N04 · Combination-study product identity

Required materials and conditions: Cod-liver-oil product/combination ingredients versus single-ingredient attribution
Conditions for verification: Relevant originals and analysis scope for Cod-liver-oil product/combination ingredients versus single-ingredient attribution should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Cod-liver-oil product/combination ingredients versus single-ingredient attribution to connect materials needed for the selected question with available materials.
Referenced methods: M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application

N05 · Flavour-matched corn-oil placebo

Required materials and conditions: Actual placebo, ingredients/sensory features and contact comparison
Conditions for verification: Relevant originals and analysis scope for Actual placebo, ingredients/sensory features and contact comparison should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Actual placebo, ingredients/sensory features and contact comparison to connect materials needed for the selected question with available materials.
Referenced methods: M03 §3.2.2–3.2.3; reverse-direction labels and testing adaptations are internally designed; M08 Table 8.2.a, M03 §3.2.4; internal application

N06 · Winter and a median 164 days

Required materials and conditions: Duration/median versus individual exposure/observation windows
Conditions for verification: Relevant originals and analysis scope for Duration/median versus individual exposure/observation windows should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Duration/median versus individual exposure/observation windows to connect materials needed for the selected question with available materials.
Referenced methods: M03 §3.2.4 and M15 §§15.3.1–15.3.3; question-specific outcome adaptation is Chamgap-designed; M03 §3.2.3 and M08 §§8.2.2–8.2.3; Chamgap adaptation; M03 §§3.2.1–3.2.4; dose, durability and effect-modification details are Chamgap-designed

N07 · Independent allocation department and concealment

Required materials and conditions: Historical randomization procedures versus actual original-text access
Conditions for verification: Relevant originals and analysis scope for Historical randomization procedures versus actual original-text access should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Historical randomization procedures versus actual original-text access to connect materials needed for the selected question with available materials.
Referenced methods: M08 §8.1–8.2.3; internal application; M04 §4.5–4.6 collection/selection principles; access/reading separation and hyperlink specifications are internally designed

N08 · Quadruple masking and each role

Required materials and conditions: Masking of participants, researchers/care and data/assessment/analysis personnel
Conditions for verification: Relevant originals and analysis scope for Masking of participants, researchers/care and data/assessment/analysis personnel should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Masking of participants, researchers/care and data/assessment/analysis personnel to connect materials needed for the selected question with available materials.
Referenced methods: M08 Table 8.2.a, M03 §3.2.4; CHAMGAP adaptation; Material collection/selection principles in M04 §4.5–4.6; Separating access from reading and defining hyperlink behavior are designed by CHAMGAP

N09 · Self-reported ARI definition

Required materials and conditions: Self-report, symptoms, diagnostic confirmation and first/repeated infections
Conditions for verification: Relevant originals and analysis scope for Self-report, symptoms, diagnostic confirmation and first/repeated infections should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Self-report, symptoms, diagnostic confirmation and first/repeated infections to connect materials needed for the selected question with available materials.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M08 Table 8.2.a, M03 §3.2.4; internal application; M08 §8.2.2, M15 §15.3.1; internal application

N10 · Self-reported ARI counts and RR

Required materials and conditions: Original counts/effects/CI and exact units/denominators
Conditions for verification: Relevant originals and analysis scope for Original counts/effects/CI and exact units/denominators should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Original counts/effects/CI and exact units/denominators to connect materials needed for the selected question with available materials.
Referenced methods: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are internally designed; M15 §15.3.1–15.3.3; internal application; M08 §8.2.2, M15 §15.3.1; internal application

N11 · Negative SARS-CoV-2 test indicator

Required materials and conditions: Negative tests versus ARI/other-pathogen confirmation
Conditions for verification: Relevant originals and analysis scope for Negative tests versus ARI/other-pathogen confirmation should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Negative tests versus ARI/other-pathogen confirmation to connect materials needed for the selected question with available materials.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M08 Table 8.2.a, M03 §3.2.4; internal application; M08 §8.2.2, M15 §15.3.1; internal application

N12 · Testing selection and confirmed-ARI gaps

Required materials and conditions: Self-report/testing and confirmed/unconfirmed infection scope
Conditions for verification: Relevant originals and analysis scope for Self-report/testing and confirmed/unconfirmed infection scope should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Self-report/testing and confirmed/unconfirmed infection scope to connect materials needed for the selected question with available materials.
Referenced methods: M08 Table 8.2.a, M03 §3.2.4; own application; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is independently designed; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is independently designed

N13 · PCR COVID-19 is a related outcome

Required materials and conditions: PCR-confirmed COVID-19 versus other ARI endpoints
Conditions for verification: Relevant originals and analysis scope for PCR-confirmed COVID-19 versus other ARI endpoints should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing PCR-confirmed COVID-19 versus other ARI endpoints to connect materials needed for the selected question with available materials.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M04 §4.6.1–4.6.2 distinguishes studies from reports; cohort/outcome links are an internal application; M15 §15.3.1–15.3.3; internal application

N14 · Serious COVID-19 is a related outcome

Required materials and conditions: Serious-outcome definitions/events/ratios versus other ARI
Conditions for verification: Relevant originals and analysis scope for Serious-outcome definitions/events/ratios versus other ARI should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Serious-outcome definitions/events/ratios versus other ARI to connect materials needed for the selected question with available materials.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M04 §4.6.1–4.6.2 distinguishes studies from reports; cohort/outcome links are an internal application; M15 §15.3.1–15.3.3; internal application

N15 · Four coprimary outcomes and fallback

Required materials and conditions: Coprimary outcomes/multiplicity, adjusted CI and prespecified hierarchy
Conditions for verification: Relevant originals and analysis scope for Coprimary outcomes/multiplicity, adjusted CI and prespecified hierarchy should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Coprimary outcomes/multiplicity, adjusted CI and prespecified hierarchy to connect materials needed for the selected question with available materials.
Referenced methods: M08 Table 8.2.a, M04 §4.6.3; internal application; M04 §4.6.3, M15 §15.3.1–15.3.3; status separation is internally designed; M04 §4.6.1–4.6.2 distinguishes studies from reports; cohort/outcome links are an internal application

N16 · 34,601·17,278/17,323

Required materials and conditions: Randomized population versus indicator-specific observations/denominators
Conditions for verification: Relevant originals and analysis scope for Randomized population versus indicator-specific observations/denominators should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Randomized population versus indicator-specific observations/denominators to connect materials needed for the selected question with available materials.
Referenced methods: M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application

N17 · ITT and 0.05% key-variable missingness

Required materials and conditions: Analysis by assignment and variable-specific missingness/handling scope
Conditions for verification: Relevant originals and analysis scope for Analysis by assignment and variable-specific missingness/handling scope should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Analysis by assignment and variable-specific missingness/handling scope to connect materials needed for the selected question with available materials.
Referenced methods: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are internally designed; M08 §8.2.2, M15 §15.3.1; internal application; M04 §4.5–4.6 collection/selection principles; access/reading separation and hyperlink specifications are internally designed

N18 · People, symptom days, repetitions and tests

Required materials and conditions: Outcome units and repetition/time overlap handling
Conditions for verification: Relevant originals and analysis scope for Outcome units and repetition/time overlap handling should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Outcome units and repetition/time overlap handling to connect materials needed for the selected question with available materials.
Referenced methods: M04 §4.6.1–4.6.2 distinguishes studies from reports; cohort/outcome links are an internal application; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are internally designed

N19 · Actual intake and concurrent exposures

Required materials and conditions: Original exposure/duration versus adherence, vitamins and behaviour/testing differences
Conditions for verification: Relevant originals and analysis scope for Original exposure/duration versus adherence, vitamins and behaviour/testing differences should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Original exposure/duration versus adherence, vitamins and behaviour/testing differences to connect materials needed for the selected question with available materials.
Referenced methods: M03 §3.2.3, M08 §8.2.2–8.2.3; own application; M03 §3.2.2–3.2.3; reverse-direction labels and test adaptations are our own design

N20 · Between-arm RR/CI and the scope of null findings

Required materials and conditions: Original relative effects/adjusted CI, within/between-arm and zero/equivalence distinctions
Conditions for verification: Relevant originals and analysis scope for Original relative effects/adjusted CI, within/between-arm and zero/equivalence distinctions should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Original relative effects/adjusted CI, within/between-arm and zero/equivalence distinctions to connect materials needed for the selected question with available materials.
Referenced methods: M08 §8.2.2, M15 §15.3.1; internal application; M15 §15.3.1–15.3.3; internal application; M04 §4.6.3, M15 §15.3.1–15.3.3; status separation is internally designed

N21 · NCT, prespecified dates and original plans

Required materials and conditions: Registration identifier/dates and preserved prespecified coprimary scope
Conditions for verification: Relevant originals and analysis scope for Registration identifier/dates and preserved prespecified coprimary scope should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Registration identifier/dates and preserved prespecified coprimary scope to connect materials needed for the selected question with available materials.
Referenced methods: M08 Table 8.2.a, M04 §4.6.3; custom application; M04 §4.5–4.6 material-collection/selection principles; separation of access/reading and hyperlink conventions are custom design; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design

N22 · Manufacturer funding and products/placebo

Required materials and conditions: Orkla support items/roles and product identity
Conditions for verification: Relevant originals and analysis scope for Orkla support items/roles and product identity should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Orkla support items/roles and product identity to connect materials needed for the selected question with available materials.
Referenced methods: Chamgap’s own independence/attribution conditions. Official methodological sections used in this pilot do not guarantee every detailed item; M03 §3.2.2–3.2.3; reverse-direction labels and testing adaptations are internally designed

N23 · University/hospital and other support

Required materials and conditions: Oslo institutional support and item-specific roles
Conditions for verification: Relevant originals and analysis scope for Oslo institutional support and item-specific roles should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Oslo institutional support and item-specific roles to connect materials needed for the selected question with available materials.
Referenced methods: Chamgap's own conditions for independence and attribution. The official methodological sections used in this example do not validate every detail of these items.

N24 · Outside relationships and employee authors

Required materials and conditions: KBH/SMU outside relationships and AS/KTK affiliation scope
Conditions for verification: Relevant originals and analysis scope for KBH/SMU outside relationships and AS/KTK affiliation scope should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing KBH/SMU outside relationships and AS/KTK affiliation scope to connect materials needed for the selected question with available materials.
Referenced methods: Chamgap’s own independence/attribution conditions. Official methodological sections used in this pilot do not guarantee every detailed item; M04 §4.5, §4.6.3; current material-conversion limits follow review scope and internal design

N25 · One trial, four indicators and related sheets

Required materials and conditions: Report→cohort→indicator/time links and independent replication
Conditions for verification: Relevant originals and analysis scope for Report→cohort→indicator/time links and independent replication should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Report→cohort→indicator/time links and independent replication to connect materials needed for the selected question with available materials.
Referenced methods: Study/report distinction in M04 §4.6.1–4.6.2; Cohort/outcome linkage is Chamgap application; M04 §4.6.1–4.6.2 and M15 §15.3.1; Chamgap application

N26 · Deficiency, high dose, ingredients and long-term scope

Required materials and conditions: Winter combination product versus other ingredient/treatment/duration applications
Conditions for verification: Relevant originals and analysis scope for Winter combination product versus other ingredient/treatment/duration applications should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Winter combination product versus other ingredient/treatment/duration applications to connect materials needed for the selected question with available materials.
Referenced methods: M03 §3.2.1–3.2.4; dose/duration/effect-modification details are internally designed; M03 §3.2.2–3.2.3; reverse-direction labels and testing adaptations are internally designed; M03 §3.2.4; internal extension boundaries

N27 · Original safety record and low-grade reporting

Required materials and conditions: Low-grade side effects, arm-specific frequencies/denominators and long-term harms
Conditions for verification: Relevant originals and analysis scope for Low-grade side effects, arm-specific frequencies/denominators and long-term harms should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Supplementary
Application exceptions: Supplements safety-information gaps for the selected subclaim. ARI/test/PCR/serious results or parent safety wording do not yield safety verdicts, harm incidence or new use instructions.
Why this condition is needed: An application item distinguishing Low-grade side effects, arm-specific frequencies/denominators and long-term harms to connect materials needed for the selected question with available materials.
Referenced methods: M19 §19.1.2–19.2.4; detailed distinctions are Chamgap’s own design; M19 §19.1.2–19.2.4; Chamgap application; M19 §19.1.2–19.2.4; Chamgap application; M19 §19.1.2–19.2.4; Chamgap application

N28 · Original axes, bilingual text, dates and history

Required materials and conditions: Original parent/subclaim values, axes, corrections and historical verification
Conditions for verification: Relevant originals and analysis scope for Original parent/subclaim values, axes, corrections and historical verification should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Original parent/subclaim values, axes, corrections and historical verification to connect materials needed for the selected question with available materials.
Referenced methods: M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design; M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed

N29 · Actual summary reading, links and gaps

Required materials and conditions: Reading preserved summaries versus external text/registration/plan access
Conditions for verification: Relevant originals and analysis scope for Reading preserved summaries versus external text/registration/plan access should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: An application item distinguishing Reading preserved summaries versus external text/registration/plan access to connect materials needed for the selected question with available materials.
Referenced methods: M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Preserved method HTML copies; no current method-content re-review or official tool execution

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Preserved method HTML copies; no current method-content re-review or official tool execution

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Preserved method HTML copies; no current method-content re-review or official tool execution

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Preserved method HTML copies; no current method-content re-review or official tool execution

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Preserved method HTML copies; no current method-content re-review or official tool execution

What the statuses mean

Met: Status for necessary evidence confirmed after existing content review. No completion is declared in the current presentation.
Partly verified: Some information in the stored summary is linked into the table. External comparison/content review is not complete.
Unverified: The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.
Review incomplete: Existing content review remains incomplete.
Not reported: Not reported within the stored material actually read; not extended to the entire primary paper.
Inaccessible: Means an actual access failure. Access not attempted here is not assigned this state.
Not applicable: Not used as a substitute for an evidence gap.
Conflicting data: Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.
Insufficient evidence for the conditions: Marks a gap in additional material required by the selected conditions; not a new efficacy grade.

Change history

2026-10-14 · Public page/material version 1.0

Public pages and materials were created from the existing 29 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-08-26) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Selected ARI question and original grade

Current findings: The selected subclaim is reduced other acute respiratory infections, grade D, with a note that both indicators were null. Subclaim score/status/axes are absent; parent D with 34 points is not used to fill the subclaim score.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Subclaim score/status/axes are absent; PCR/serious results are not transferred to the same ARI outcome. Existing content review remains incomplete.
Reason for missing information: Subclaim score/status/axes are absent; PCR/serious results are not transferred to the same ARI outcome.
Required materials and conditions: Existing question/grade/note versus the parent coprimary verdict
Materials to obtain first: Original selected-subclaim/parent records and user correction comments
Further research: Proposed follow-up comparative research specifying the ARI question/indicators; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Existing question/grade/note versus the parent coprimary verdict should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Existing question/grade/note versus the parent coprimary verdict to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are custom design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is custom design; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design

Related sources S01

N02 · Norwegian adults and routine supplementation

Current findings: This was a winter trial in Norwegian adults not routinely taking vitamin D daily. Do not extend the effect to every population/season or those taking daily supplements.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Age/baseline conditions, eligibility/recruitment, diet/baseline supplement amounts and balance by population remain unverified. Existing content review remains incomplete.
Reason for missing information: Age/baseline conditions, eligibility/recruitment, diet/baseline supplement amounts and balance by population remain unverified.
Required materials and conditions: Actual population, eligibility, routine vitamin D exposure and season
Materials to obtain first: Population/recruitment and baseline characteristics/supplement-exposure tables
Further research: Proposed follow-up research specifying population and prior exposure; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Actual population, eligibility, routine vitamin D exposure and season should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Actual population, eligibility, routine vitamin D exposure and season to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.1; Detailed population conditions are Chamgap design; M03 §3.2.1–3.2.4; Dose, duration and effect-modifier details are Chamgap design

Related sources S01

N03 · Baseline vitamin D status and treatment scope

Current findings: Not taking daily vitamin D supplements is not converted to confirmed normal vitamin D or deficiency. The original verdict records that deficiency treatment is outside scope.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Baseline vitamin D measurements/distribution, deficiency diagnoses and status-specific analyses remain unverified. Existing content review remains incomplete.
Reason for missing information: Baseline vitamin D measurements/distribution, deficiency diagnoses and status-specific analyses remain unverified.
Required materials and conditions: Supplement habits versus deficiency diagnosis/baseline status
Materials to obtain first: Baseline status, measurement/subgroup analyses and eligibility materials
Further research: Proposed research separating baseline status from the selected combination-product scope; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Supplement habits versus deficiency diagnosis/baseline status should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Supplement habits versus deficiency diagnosis/baseline status to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.1; Detailed population criteria are designed by CHAMGAP; M03 §3.2.1–3.2.4; Dose, duration and effect-modification details are designed by CHAMGAP; M03 §3.2.2–3.2.3; Reverse labels and test adaptations are designed by CHAMGAP

Related sources S01

N04 · Combination-study product identity

Current findings: Cod liver oil 5 mL/day supplied vitamin D 10 µg and about 1 g n-3 fatty acids. The combination result is not transferred to vitamin D/omega-3 alone or high-dose treatment; no new dose conversion is made.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Product/batches, full ingredient/specification details and direct single-ingredient effects remain unverified. Existing content review remains incomplete.
Reason for missing information: Product/batches, full ingredient/specification details and direct single-ingredient effects remain unverified.
Required materials and conditions: Cod-liver-oil product/combination ingredients versus single-ingredient attribution
Materials to obtain first: Study-product ingredients/manufacture and combination/individual attribution materials
Further research: Proposed follow-up research separating the same combination product from ingredient attribution; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Cod-liver-oil product/combination ingredients versus single-ingredient attribution should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Cod-liver-oil product/combination ingredients versus single-ingredient attribution to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application

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N05 · Flavour-matched corn-oil placebo

Current findings: The comparator was flavour-matched corn-oil placebo. The name does not establish matching of every ingredient/sensory/contact feature or absence of biological placebo effects.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Placebo composition/specifications, maintained masking, contact/instructions and other exposure differences remain unverified. Existing content review remains incomplete.
Reason for missing information: Placebo composition/specifications, maintained masking, contact/instructions and other exposure differences remain unverified.
Required materials and conditions: Actual placebo, ingredients/sensory features and contact comparison
Materials to obtain first: Placebo/sensory, manufacture and contact/masking data
Further research: Proposed follow-up trial disclosing actual comparison conditions; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Actual placebo, ingredients/sensory features and contact comparison should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Actual placebo, ingredients/sensory features and contact comparison to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.2–3.2.3; reverse-direction labels and testing adaptations are internally designed; M08 Table 8.2.a, M03 §3.2.4; internal application

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N06 · Winter and a median 164 days

Current findings: Original median 164 days of use and about six winter months are preserved. Do not turn this into identical exact duration/complete intake for everyone or a sustained year-round effect.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Individual durations, start/end/assessment windows, actual exposure/discontinuation and follow-up periods remain unverified. Existing content review remains incomplete.
Reason for missing information: Individual durations, start/end/assessment windows, actual exposure/discontinuation and follow-up periods remain unverified.
Required materials and conditions: Duration/median versus individual exposure/observation windows
Materials to obtain first: Duration/visits, exposure/discontinuation and follow-up materials
Further research: Proposed follow-up research separating planned/actual duration and season; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Duration/median versus individual exposure/observation windows should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Duration/median versus individual exposure/observation windows to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.4 and M15 §§15.3.1–15.3.3; question-specific outcome adaptation is Chamgap-designed; M03 §3.2.3 and M08 §§8.2.2–8.2.3; Chamgap adaptation; M03 §§3.2.1–3.2.4; dose, durability and effect-modification details are Chamgap-designed

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N07 · Independent allocation department and concealment

Current findings: The original text records randomization by Oslo University Hospital’s research-support department without investigator involvement. This is not upgraded to current allocation/concealment verification.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Sequence/concealment, implementation/exceptions, baseline balance and original protocol remain unread. Existing content review remains incomplete.
Reason for missing information: Sequence/concealment, implementation/exceptions, baseline balance and original protocol remain unread.
Required materials and conditions: Historical randomization procedures versus actual original-text access
Materials to obtain first: Original allocation/concealment, baseline and protocol materials
Further research: Proposed follow-up trial disclosing allocation procedures; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Historical randomization procedures versus actual original-text access should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Historical randomization procedures versus actual original-text access to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 §8.1–8.2.3; internal application; M04 §4.5–4.6 collection/selection principles; access/reading separation and hyperlink specifications are internally designed

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N08 · Quadruple masking and each role

Current findings: The original text records quadruple masking and masking of several roles to assignment. Historical descriptions do not establish current verification of maintenance/unmasking or expectation effects on self-reports.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Original masking success/maintenance, unmasking, measurement/analysis roles and expectation effects remain unread. Existing content review remains incomplete.
Reason for missing information: Original masking success/maintenance, unmasking, measurement/analysis roles and expectation effects remain unread.
Required materials and conditions: Masking of participants, researchers/care and data/assessment/analysis personnel
Materials to obtain first: Original masking roles/maintenance and measurement/analysis materials
Further research: Proposed follow-up research specifying masking and self-reported measurement; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Masking of participants, researchers/care and data/assessment/analysis personnel should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Masking of participants, researchers/care and data/assessment/analysis personnel to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 Table 8.2.a, M03 §3.2.4; CHAMGAP adaptation; Material collection/selection principles in M04 §4.5–4.6; Separating access from reading and defining hyperlink behavior are designed by CHAMGAP

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N09 · Self-reported ARI definition

Current findings: One selected indicator is self-reported acute respiratory infection. It is not converted to test/clinician-confirmed other-pathogen infection, PCR COVID-19 or serious outcomes.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Symptom/question definitions, recall/report windows, medical/test confirmation and first/repeated-event handling remain unverified. Existing content review remains incomplete.
Reason for missing information: Symptom/question definitions, recall/report windows, medical/test confirmation and first/repeated-event handling remain unverified.
Required materials and conditions: Self-report, symptoms, diagnostic confirmation and first/repeated infections
Materials to obtain first: Self-reported ARI definitions, questionnaires/adjudication and event-handling data
Further research: Proposed follow-up research separating self-reports from confirmed infections; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Self-report, symptoms, diagnostic confirmation and first/repeated infections should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Self-report, symptoms, diagnostic confirmation and first/repeated infections to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M08 Table 8.2.a, M03 §3.2.4; internal application; M08 §8.2.2, M15 §15.3.1; internal application

Related sources S01

N10 · Self-reported ARI counts and RR

Current findings: Original self-reported ARI was 3,964 versus 3,834, RR 1.04 (0.97–1.11). No new proportions/absolute differences/CI or symptom-day/event totals are calculated.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Whether counts concern people/first/repeated events, effective denominators, adjustments/models and exact P values remain unverified. Existing content review remains incomplete.
Reason for missing information: Whether counts concern people/first/repeated events, effective denominators, adjustments/models and exact P values remain unverified.
Required materials and conditions: Original counts/effects/CI and exact units/denominators
Materials to obtain first: ARI result tables, units/denominators and model/CI materials
Further research: Proposed research disclosing units/denominators together with effects; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Original counts/effects/CI and exact units/denominators should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Original counts/effects/CI and exact units/denominators to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are internally designed; M15 §15.3.1–15.3.3; internal application; M08 §8.2.2, M15 §15.3.1; internal application

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N11 · Negative SARS-CoV-2 test indicator

Current findings: Negative SARS-CoV-2 tests were a separate coprimary indicator: 8,546 versus 8,565, RR 1.00 (0.97–1.04). They are not treated as other-pathogen diagnoses or the same outcome as self-reported ARI.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Testing populations/reasons, units/repetition, test types, accompanying symptoms and other-pathogen confirmation remain unverified. Existing content review remains incomplete.
Reason for missing information: Testing populations/reasons, units/repetition, test types, accompanying symptoms and other-pathogen confirmation remain unverified.
Required materials and conditions: Negative tests versus ARI/other-pathogen confirmation
Materials to obtain first: Negative-test definitions and testing/symptom/confirmation materials
Further research: Proposed follow-up research separating negative tests from actual ARI confirmation; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Negative tests versus ARI/other-pathogen confirmation should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Negative tests versus ARI/other-pathogen confirmation to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M08 Table 8.2.a, M03 §3.2.4; internal application; M08 §8.2.2, M15 §15.3.1; internal application

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N12 · Testing selection and confirmed-ARI gaps

Current findings: Original materials record negative tests and self-reported ARI separately. The indicators are not combined into new clinician/pathogen-confirmed ARI counts.
Verification status: Unverified
Materials actually read: Summary read; external material unread
Why unverified: Required current information remains unverified in the preserved summary. Testing/reporting flow, symptom/test timing, sensitivity/adjudication and separate confirmed non-COVID ARI results remain unverified. Existing content review remains incomplete.
Reason for missing information: Testing/reporting flow, symptom/test timing, sensitivity/adjudication and separate confirmed non-COVID ARI results remain unverified.
Required materials and conditions: Self-report/testing and confirmed/unconfirmed infection scope
Materials to obtain first: Testing/reporting flow and confirmed-ARI definitions/results
Further research: Proposed research separating self-report/testing selection from confirmed results; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Self-report/testing and confirmed/unconfirmed infection scope should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Self-report/testing and confirmed/unconfirmed infection scope to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 Table 8.2.a, M03 §3.2.4; own application; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is independently designed; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is independently designed

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N13 · PCR COVID-19 is a related outcome

Current findings: Original PCR infection was 227 versus 228, RR 1.00 (adjusted 95% CI 0.82–1.22). This is not transferred to events/effects for self-reported ARI or negative tests.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Specific PCR tests/denominators/models and ARI overlap/exclusion remain unverified. Existing content review remains incomplete.
Reason for missing information: Specific PCR tests/denominators/models and ARI overlap/exclusion remain unverified.
Required materials and conditions: PCR-confirmed COVID-19 versus other ARI endpoints
Materials to obtain first: PCR/ARI definitions, overlap/denominators and models
Further research: Proposed follow-up research reporting related endpoints separately; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for PCR-confirmed COVID-19 versus other ARI endpoints should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing PCR-confirmed COVID-19 versus other ARI endpoints to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M04 §4.6.1–4.6.2 distinguishes studies from reports; cohort/outcome links are an internal application; M15 §15.3.1–15.3.3; internal application

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N14 · Serious COVID-19 is a related outcome

Current findings: Original serious COVID-19 was 121 versus 101, RR 1.20 (0.87–1.65). Do not combine this as selected ARI severity/effects or all infection events.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Serious components/adjudication, effective denominators, overlap/models and selected ARI severity remain unverified. Existing content review remains incomplete.
Reason for missing information: Serious components/adjudication, effective denominators, overlap/models and selected ARI severity remain unverified.
Required materials and conditions: Serious-outcome definitions/events/ratios versus other ARI
Materials to obtain first: Serious/PCR/ARI definitions, components/overlap and results
Further research: Proposed follow-up research separating endpoint components/overlap; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Serious-outcome definitions/events/ratios versus other ARI should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Serious-outcome definitions/events/ratios versus other ARI to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M04 §4.6.1–4.6.2 distinguishes studies from reports; cohort/outcome links are an internal application; M15 §15.3.1–15.3.3; internal application

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N15 · Four coprimary outcomes and fallback

Current findings: Original descriptions of four coprimary endpoints, prespecified fallback multiplicity control and all-null findings are preserved. Each indicator is not turned into an independent trial or new success/exactly-zero-effect verdict for a single subclaim.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Fallback rules/order, full adjustment/testing specifications and SAP/amendments remain unread. Existing content review remains incomplete.
Reason for missing information: Fallback rules/order, full adjustment/testing specifications and SAP/amendments remain unread.
Required materials and conditions: Coprimary outcomes/multiplicity, adjusted CI and prespecified hierarchy
Materials to obtain first: Original registration/protocol/SAP and multiplicity/CI materials
Further research: Proposed follow-up research specifying coprimary outcomes and adjusted results; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Coprimary outcomes/multiplicity, adjusted CI and prespecified hierarchy should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Coprimary outcomes/multiplicity, adjusted CI and prespecified hierarchy to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 Table 8.2.a, M04 §4.6.3; internal application; M04 §4.6.3, M15 §15.3.1–15.3.3; status separation is internally designed; M04 §4.6.1–4.6.2 distinguishes studies from reports; cohort/outcome links are an internal application

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N16 · 34,601·17,278/17,323

Current findings: Original randomization of 34,601 adults and arm sizes 17,278/17,323 are preserved. They are not automatically filled in as every indicator’s observation/person/event denominator.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Indicator-specific effective/observed/at-risk denominators, repeated tests/reports and unobserved-data definitions remain unverified. Existing content review remains incomplete.
Reason for missing information: Indicator-specific effective/observed/at-risk denominators, repeated tests/reports and unobserved-data definitions remain unverified.
Required materials and conditions: Randomized population versus indicator-specific observations/denominators
Materials to obtain first: Randomized/indicator-specific denominators and observation/report flow
Further research: Proposed follow-up research distinguishing recruitment/observation/analysis denominators; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Randomized population versus indicator-specific observations/denominators should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Randomized population versus indicator-specific observations/denominators to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application

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N17 · ITT and 0.05% key-variable missingness

Current findings: Original ITT for all randomized participants and 0.05% key-variable missingness are preserved. They do not verify no missingness or complete observation for every questionnaire/test/symptom-day outcome.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Variable/arm/period-specific missingness, handling/models, follow-up/sensitivity and actual original text remain unread. Existing content review remains incomplete.
Reason for missing information: Variable/arm/period-specific missingness, handling/models, follow-up/sensitivity and actual original text remain unread.
Required materials and conditions: Analysis by assignment and variable-specific missingness/handling scope
Materials to obtain first: Variable-specific missingness, analysis populations and handling/sensitivity data
Further research: Proposed research reporting differences between variable-specific observation and ITT estimation; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Analysis by assignment and variable-specific missingness/handling scope should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Analysis by assignment and variable-specific missingness/handling scope to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are internally designed; M08 §8.2.2, M15 §15.3.1; internal application; M04 §4.5–4.6 collection/selection principles; access/reading separation and hyperlink specifications are internally designed

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N18 · People, symptom days, repetitions and tests

Current findings: The four original counts/indicators are preserved separately. People, infection episodes, symptom days, tests and related sheets are not counted as new participant/event/independent-trial totals.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. First/all/repeated-event definitions, symptom days, individual overlap and period-specific observation/time remain unverified. Existing content review remains incomplete.
Reason for missing information: First/all/repeated-event definitions, symptom days, individual overlap and period-specific observation/time remain unverified.
Required materials and conditions: Outcome units and repetition/time overlap handling
Materials to obtain first: Indicator-specific units/repetition, time and overlap data
Further research: Proposed research separately reporting people/events/days/test units; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Outcome units and repetition/time overlap handling should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Outcome units and repetition/time overlap handling to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M04 §4.6.1–4.6.2 distinguishes studies from reports; cohort/outcome links are an internal application; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are internally designed

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N19 · Actual intake and concurrent exposures

Current findings: 5 mL/day and a median 164 days describe study exposure/duration. Actual complete intake or matching of concurrent vitamins/medications and lifestyle/prevention/testing conditions are not confirmed.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Adherence/discontinuation, additional supplements/medications, lifestyle/prevention, testing/contact and their analyses remain unverified. Existing content review remains incomplete.
Reason for missing information: Adherence/discontinuation, additional supplements/medications, lifestyle/prevention, testing/contact and their analyses remain unverified.
Required materials and conditions: Original exposure/duration versus adherence, vitamins and behaviour/testing differences
Materials to obtain first: Actual exposure, adherence/discontinuation and concurrent-condition data
Further research: Proposed follow-up research specifying actual exposure and concurrent conditions; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Original exposure/duration versus adherence, vitamins and behaviour/testing differences should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Original exposure/duration versus adherence, vitamins and behaviour/testing differences to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.3, M08 §8.2.2–8.2.3; own application; M03 §3.2.2–3.2.3; reverse-direction labels and test adaptations are our own design

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N20 · Between-arm RR/CI and the scope of null findings

Current findings: Original ARI-related RRs/CI are retained. Within-arm symptom changes, RR near 1.00 or nonsignificance do not newly establish exactly zero effect, equivalence or absence of benefit/harm in every population.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Exact contrasts/models, adjustments, P, importance/equivalence criteria and indicator-specific estimation specifications remain unread. Existing content review remains incomplete.
Reason for missing information: Exact contrasts/models, adjustments, P, importance/equivalence criteria and indicator-specific estimation specifications remain unread.
Required materials and conditions: Original relative effects/adjusted CI, within/between-arm and zero/equivalence distinctions
Materials to obtain first: Indicator-specific models, contrasts/CI and prespecified criteria
Further research: Proposed follow-up research reporting effects/precision and applicability; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Original relative effects/adjusted CI, within/between-arm and zero/equivalence distinctions should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Original relative effects/adjusted CI, within/between-arm and zero/equivalence distinctions to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 §8.2.2, M15 §15.3.1; internal application; M15 §15.3.1–15.3.3; internal application; M04 §4.6.3, M15 §15.3.1–15.3.3; status separation is internally designed

Related sources S01

N21 · NCT, prespecified dates and original plans

Current findings: Original NCT04609423, posted 2020-10-30 and started 2020-11-10, are retained. Prospective/matching-coprimary descriptions are not upgraded to current full registration/plan verification.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Registration amendments, protocol/SAP and full indicator definition/testing/plans remain unread. Existing content review remains incomplete.
Reason for missing information: Registration amendments, protocol/SAP and full indicator definition/testing/plans remain unread.
Required materials and conditions: Registration identifier/dates and preserved prespecified coprimary scope
Materials to obtain first: Registration history, protocol, and SAP
Further research: Proposed research linking and disclosing prespecified coprimary outcomes and actual analysis; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Registration identifier/dates and preserved prespecified coprimary scope should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Registration identifier/dates and preserved prespecified coprimary scope to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 Table 8.2.a, M04 §4.6.3; custom application; M04 §4.5–4.6 material-collection/selection principles; separation of access/reading and hyperlink conventions are custom design; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design

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N22 · Manufacturer funding and products/placebo

Current findings: Möller’s Tran manufacturer Orkla Health AS supplied funding, cod liver oil and placebo. Original context of a large null report for its own product is retained; funding alone does not yield a new independence/effect verdict.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Contracts, design/analysis/data/publication authority, original support text and full product/batch details remain unread. Existing content review remains incomplete.
Reason for missing information: Contracts, design/analysis/data/publication authority, original support text and full product/batch details remain unread.
Required materials and conditions: Orkla support items/roles and product identity
Materials to obtain first: Funding, product/placebo supply and role disclosures
Further research: Proposed follow-up trial disclosing support/research roles; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Orkla support items/roles and product identity should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Orkla support items/roles and product identity to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: Chamgap’s own independence/attribution conditions. Official methodological sections used in this pilot do not guarantee every detailed item; M03 §3.2.2–3.2.3; reverse-direction labels and testing adaptations are internally designed

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N23 · University/hospital and other support

Current findings: Original Oslo University Hospital/University of Oslo support is retained. Public/university support does not replace manufacturer support or establish absence of all other support/COI.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Cash/in-kind support, institutional roles, external analysis/medical writing/publication costs and full support disclosures remain unread. Existing content review remains incomplete.
Reason for missing information: Cash/in-kind support, institutional roles, external analysis/medical writing/publication costs and full support disclosures remain unread.
Required materials and conditions: Oslo institutional support and item-specific roles
Materials to obtain first: Institutional/other support and role/writing/publication disclosures
Further research: Proposed research separately disclosing support items and roles; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Oslo institutional support and item-specific roles should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Oslo institutional support and item-specific roles to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: Chamgap's own conditions for independence and attribution. The official methodological sections used in this example do not validate every detail of these items.

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N24 · Outside relationships and employee authors

Current findings: Original KBH relationships with Olympic Seafood/Amgen/Sanofi, SMU with Olympic Seafood outside this study, and AS/KTK employment at Age Laboratories AS are retained. They are not converted to the same relationship as trial funding/product supply.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Relationships/contributions, contemporaneous contracts, diagnostic/analysis/data/publication roles and full COI disclosures remain unread. Existing content review remains incomplete.
Reason for missing information: Relationships/contributions, contemporaneous contracts, diagnostic/analysis/data/publication roles and full COI disclosures remain unread.
Required materials and conditions: KBH/SMU outside relationships and AS/KTK affiliation scope
Materials to obtain first: Original author affiliations/contributions and outside relationships/COI
Further research: Proposed research distinguishing and disclosing relationships inside/outside the study and roles; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for KBH/SMU outside relationships and AS/KTK affiliation scope should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing KBH/SMU outside relationships and AS/KTK affiliation scope to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: Chamgap’s own independence/attribution conditions. Official methodological sections used in this pilot do not guarantee every detailed item; M04 §4.5, §4.6.3; current material-conversion limits follow review scope and internal design

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N25 · One trial, four indicators and related sheets

Current findings: S01 Brunvoll 2022 concerns the same trial of 34,601 adults. Four coprimary indicators, people/tests/time points, citations/registration and related sheets are not added as new independent trials/participants.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Independent replication matching formulation/population/ARI specifications and unique clinical totals are not established. Existing content review remains incomplete.
Reason for missing information: Independent replication matching formulation/population/ARI specifications and unique clinical totals are not established.
Required materials and conditions: Report→cohort→indicator/time links and independent replication
Materials to obtain first: Report/cohort/registration relationships and separate original studies
Further research: Proposal for later independent comparative research on the same selected question; no new investigation, calculation or trial was performed in that production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Report→cohort→indicator/time links and independent replication should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Report→cohort→indicator/time links and independent replication to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: Study/report distinction in M04 §4.6.1–4.6.2; Cohort/outcome linkage is Chamgap application; M04 §4.6.1–4.6.2 and M15 §15.3.1; Chamgap application

Related sources S01

N26 · Deficiency, high dose, ingredients and long-term scope

Current findings: The original verdict does not address deficiency treatment, high-dose vitamin D or omega-3 alone. A null combination product is not transferred to direct verdicts for those conditions/other seasons/long-term outcomes or to intake/treatment guidance.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Direct comparisons for other formulations/exposures/populations, persistence afterwards and clinical outcomes remain unverified. Existing content review remains incomplete.
Reason for missing information: Direct comparisons for other formulations/exposures/populations, persistence afterwards and clinical outcomes remain unverified.
Required materials and conditions: Winter combination product versus other ingredient/treatment/duration applications
Materials to obtain first: Direct formulation/population/duration-specific trials and follow-up data
Further research: Proposed research distinguishing combination product from other application specifications; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Winter combination product versus other ingredient/treatment/duration applications should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Winter combination product versus other ingredient/treatment/duration applications to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.1–3.2.4; dose/duration/effect-modification details are internally designed; M03 §3.2.2–3.2.3; reverse-direction labels and testing adaptations are internally designed; M03 §3.2.4; internal extension boundaries

Related sources S01

N27 · Original safety record and low-grade reporting

Current findings: Original parent good safety and low-grade side effects in both arms are retained. Scope is limited to tested dose/participants; rare/long-term harms or other-product safety are not verified.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Types/frequencies/denominators, collection/adjudication, discontinuation/causality and long-term/vulnerable-population harms remain unverified. Existing content review remains incomplete.
Reason for missing information: Types/frequencies/denominators, collection/adjudication, discontinuation/causality and long-term/vulnerable-population harms remain unverified.
Required materials and conditions: Low-grade side effects, arm-specific frequencies/denominators and long-term harms
Materials to obtain first: Safety collection, adverse-event/discontinuation and long-term follow-up data
Further research: Proposed research specifying harm collection/scope and follow-up; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Low-grade side effects, arm-specific frequencies/denominators and long-term harms should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Low-grade side effects, arm-specific frequencies/denominators and long-term harms to connect materials needed for the selected question with available materials.
Application exceptions: Supplements safety-information gaps for the selected subclaim. ARI/test/PCR/serious results or parent safety wording do not yield safety verdicts, harm incidence or new use instructions.
Referenced methods: M19 §19.1.2–19.2.4; detailed distinctions are Chamgap’s own design; M19 §19.1.2–19.2.4; Chamgap application; M19 §19.1.2–19.2.4; Chamgap application; M19 §19.1.2–19.2.4; Chamgap application

Related sources S01

N28 · Original axes, bilingual text, dates and history

Current findings: Parent D with 34 points, B/H/R1/I0/E0/B0/C0, true large-hard-endpoint-RCT and two false indicators, empty override reasons and subclaim D/note are preserved. Bilingual text, 2026-08-26, empty corrections/deliberation and cross-checking are not inherited as completed clinical review now or subclaim scores.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Absent subclaim score/status/axes are not filled with parent values; no new coprimary/method certification. Existing content review remains incomplete.
Reason for missing information: Absent subclaim score/status/axes are not filled with parent values; no new coprimary/method certification.
Required materials and conditions: Original parent/subclaim values, axes, corrections and historical verification
Materials to obtain first: Original corrections, versions and user correction comments
Further research: Proposed research distinguishing original values/history from new-update scope; no new investigation, calculation or trial was performed in this production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Original parent/subclaim values, axes, corrections and historical verification should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Original parent/subclaim values, axes, corrections and historical verification to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design; M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed

Related sources S01

N29 · Actual summary reading, links and gaps

Current findings: The full preserved summary/citations were used for production and links retained. Original papers/registration/protocol/SAP/support/COI materials remain unread, access unattempted and external links untested.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. External original content, exact definitions/denominators/models and accessibility remain unverified. Existing content review remains incomplete.
Reason for missing information: External original content, exact definitions/denominators/models and accessibility remain unverified.
Required materials and conditions: Reading preserved summaries versus external text/registration/plan access
Materials to obtain first: Original paper, registration, protocol, SAP and support materials or user comments
Further research: Proposal for updating while distinguishing actual acquisition/timing/scope; no new investigation, calculation or trial was performed in that production.
Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
Conditions for verification: Relevant originals and analysis scope for Reading preserved summaries versus external text/registration/plan access should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.
Why this condition is needed: An application item distinguishing Reading preserved summaries versus external text/registration/plan access to connect materials needed for the selected question with available materials.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design

Related sources S01