{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v2972-s2",
  "verdict_number": "2972",
  "title": "Winter cod liver oil × Reduced other acute respiratory infections",
  "view_version": "1.0",
  "view_created_date": "2026-10-14",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-08-26",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "The whole stored parent-verdict summary and selected subclaim were read for production. External papers, abstracts, full texts, registry, protocol, SAP and funding disclosures were not separately read or accessed. Historical review records are not inherited as current clinical verification or a new verdict.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "Winter trial in Norwegian adults not taking vitamin D supplements daily. Original randomized denominators: 34,601 adults, 17,278/17,323. Detailed eligibility, baseline vitamin D/conditions, indicator-specific observations/denominators and missingness/withdrawals remain unverified.",
    "intervention": "Combination cod-liver-oil study product 5 mL/day supplied vitamin D 10 µg and about 1 g n-3 fatty acids. It is not repurposed as single-ingredient, deficiency-treatment or high-dose vitamin D effects; no new intake/prevention/treatment instructions or dose conversion.",
    "dose": "Original 5 mL/day, median 164 days of use and about six winter months are preserved separately. Identical/complete exposure in every participant, daily adherence/discontinuation and follow-up windows remain unverified; no new duration/exposure conversion.",
    "comparator": "Quadruple-blinded randomized comparison with flavour-matched corn-oil placebo. Independent-department allocation, role-specific masking, all-randomized ITT and 0.05% key-variable missingness are preserved historical descriptions, not current procedural/original-text verification. Actual sensory matching, concurrent exposures and variable-specific missingness/observation remain unverified.",
    "endpoint": "Two selected other-ARI-related indicators: negative SARS-CoV-2 tests, 8,546 versus 8,565, RR 1.00 (0.97–1.04), and self-reported ARI, 3,964 versus 3,834, RR 1.04 (0.97–1.11). Negative tests are not converted to other-pathogen/clinician-confirmed ARI. PCR infection 227/228, RR 1.00 (0.82–1.22), and serious outcomes 121/101, RR 1.20 (0.87–1.65), remain separate related outcomes. Original four-coprimary/fallback/adjusted-CI descriptions are preserved; no new people/event/test/symptom-day totals, proportions/effects/CI.",
    "duration": "Winter use for a median 164 days/about six months. Actual individual observations/tests/reports/discontinuation, repetitions/symptom days and later/other-season effects remain unverified.",
    "excluded_extensions": [
      "Converting negative SARS tests to the same infection endpoint as other-pathogen/clinician-confirmed ARI or self-reported ARI",
      "Repurposing PCR/serious counts, RR or CI as selected ARI events/effects",
      "Combining four indicators/tests/symptom days/repeated counts into new people/events/period effects",
      "Converting no baseline daily supplements to confirmed normal/deficient status or repurposing combination 5 mL/vitamin D 10 µg/about 1 g n-3 as high-dose/deficiency-treatment/single-ingredient effects",
      "Treating ITT/0.05% key-variable missingness as complete observation or identical denominators for all variables/indicators",
      "Converting original RR/adjusted CI/fallback/null findings into new exactly-zero-effect/equivalence/all-population-null certification",
      "Summing people/groups/tests/events/timepoints/bibliographies, registrations or sibling sheets as new independent trials/participants",
      "Inheriting original parent values/axes or historical verification/registration/allocation/masking/analysis wording as subclaim scores or current content review/full-text reading",
      "New calculations, invented quantities, effects/CI, grades/independence certification or cod-liver-oil/vitamin/product-use/testing/infection-prevention/respiratory-management/treatment-replacement instructions"
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Selected ARI question and original grade",
      "needed": "Existing question/grade/note versus the parent coprimary verdict",
      "role": "Required",
      "role_reason": "An application item distinguishing Existing question/grade/note versus the parent coprimary verdict to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Existing question/grade/note versus the parent coprimary verdict should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are custom design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is custom design; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up comparative research specifying the ARI question/indicators; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The selected subclaim is reduced other acute respiratory infections, grade D, with a note that both indicators were null. Subclaim score/status/axes are absent; parent D with 34 points is not used to fill the subclaim score.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Subclaim score/status/axes are absent; PCR/serious results are not transferred to the same ARI outcome. Existing content review remains incomplete.",
      "missingness": "Subclaim score/status/axes are absent; PCR/serious results are not transferred to the same ARI outcome.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original selected-subclaim/parent records and user correction comments"
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Norwegian adults and routine supplementation",
      "needed": "Actual population, eligibility, routine vitamin D exposure and season",
      "role": "Required",
      "role_reason": "An application item distinguishing Actual population, eligibility, routine vitamin D exposure and season to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Actual population, eligibility, routine vitamin D exposure and season should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M03 §3.2.1; Detailed population conditions are Chamgap design; M03 §3.2.1–3.2.4; Dose, duration and effect-modifier details are Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up research specifying population and prior exposure; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "This was a winter trial in Norwegian adults not routinely taking vitamin D daily. Do not extend the effect to every population/season or those taking daily supplements.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Age/baseline conditions, eligibility/recruitment, diet/baseline supplement amounts and balance by population remain unverified. Existing content review remains incomplete.",
      "missingness": "Age/baseline conditions, eligibility/recruitment, diet/baseline supplement amounts and balance by population remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Population/recruitment and baseline characteristics/supplement-exposure tables"
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Baseline vitamin D status and treatment scope",
      "needed": "Supplement habits versus deficiency diagnosis/baseline status",
      "role": "Required",
      "role_reason": "An application item distinguishing Supplement habits versus deficiency diagnosis/baseline status to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Supplement habits versus deficiency diagnosis/baseline status should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M03 §3.2.1; Detailed population criteria are designed by CHAMGAP; M03 §3.2.1–3.2.4; Dose, duration and effect-modification details are designed by CHAMGAP; M03 §3.2.2–3.2.3; Reverse labels and test adaptations are designed by CHAMGAP",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research separating baseline status from the selected combination-product scope; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Not taking daily vitamin D supplements is not converted to confirmed normal vitamin D or deficiency. The original verdict records that deficiency treatment is outside scope.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Baseline vitamin D measurements/distribution, deficiency diagnoses and status-specific analyses remain unverified. Existing content review remains incomplete.",
      "missingness": "Baseline vitamin D measurements/distribution, deficiency diagnoses and status-specific analyses remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Baseline status, measurement/subgroup analyses and eligibility materials"
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Combination-study product identity",
      "needed": "Cod-liver-oil product/combination ingredients versus single-ingredient attribution",
      "role": "Required",
      "role_reason": "An application item distinguishing Cod-liver-oil product/combination ingredients versus single-ingredient attribution to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Cod-liver-oil product/combination ingredients versus single-ingredient attribution should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up research separating the same combination product from ingredient attribution; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Cod liver oil 5 mL/day supplied vitamin D 10 µg and about 1 g n-3 fatty acids. The combination result is not transferred to vitamin D/omega-3 alone or high-dose treatment; no new dose conversion is made.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Product/batches, full ingredient/specification details and direct single-ingredient effects remain unverified. Existing content review remains incomplete.",
      "missingness": "Product/batches, full ingredient/specification details and direct single-ingredient effects remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Study-product ingredients/manufacture and combination/individual attribution materials"
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Flavour-matched corn-oil placebo",
      "needed": "Actual placebo, ingredients/sensory features and contact comparison",
      "role": "Required",
      "role_reason": "An application item distinguishing Actual placebo, ingredients/sensory features and contact comparison to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Actual placebo, ingredients/sensory features and contact comparison should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; reverse-direction labels and testing adaptations are internally designed; M08 Table 8.2.a, M03 §3.2.4; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up trial disclosing actual comparison conditions; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The comparator was flavour-matched corn-oil placebo. The name does not establish matching of every ingredient/sensory/contact feature or absence of biological placebo effects.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Placebo composition/specifications, maintained masking, contact/instructions and other exposure differences remain unverified. Existing content review remains incomplete.",
      "missingness": "Placebo composition/specifications, maintained masking, contact/instructions and other exposure differences remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Placebo/sensory, manufacture and contact/masking data"
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Winter and a median 164 days",
      "needed": "Duration/median versus individual exposure/observation windows",
      "role": "Required",
      "role_reason": "An application item distinguishing Duration/median versus individual exposure/observation windows to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Duration/median versus individual exposure/observation windows should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M03 §3.2.4 and M15 §§15.3.1–15.3.3; question-specific outcome adaptation is Chamgap-designed; M03 §3.2.3 and M08 §§8.2.2–8.2.3; Chamgap adaptation; M03 §§3.2.1–3.2.4; dose, durability and effect-modification details are Chamgap-designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up research separating planned/actual duration and season; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original median 164 days of use and about six winter months are preserved. Do not turn this into identical exact duration/complete intake for everyone or a sustained year-round effect.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Individual durations, start/end/assessment windows, actual exposure/discontinuation and follow-up periods remain unverified. Existing content review remains incomplete.",
      "missingness": "Individual durations, start/end/assessment windows, actual exposure/discontinuation and follow-up periods remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Duration/visits, exposure/discontinuation and follow-up materials"
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Independent allocation department and concealment",
      "needed": "Historical randomization procedures versus actual original-text access",
      "role": "Required",
      "role_reason": "An application item distinguishing Historical randomization procedures versus actual original-text access to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Historical randomization procedures versus actual original-text access should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M08 §8.1–8.2.3; internal application; M04 §4.5–4.6 collection/selection principles; access/reading separation and hyperlink specifications are internally designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up trial disclosing allocation procedures; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The original text records randomization by Oslo University Hospital’s research-support department without investigator involvement. This is not upgraded to current allocation/concealment verification.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Sequence/concealment, implementation/exceptions, baseline balance and original protocol remain unread. Existing content review remains incomplete.",
      "missingness": "Sequence/concealment, implementation/exceptions, baseline balance and original protocol remain unread.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original allocation/concealment, baseline and protocol materials"
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Quadruple masking and each role",
      "needed": "Masking of participants, researchers/care and data/assessment/analysis personnel",
      "role": "Required",
      "role_reason": "An application item distinguishing Masking of participants, researchers/care and data/assessment/analysis personnel to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Masking of participants, researchers/care and data/assessment/analysis personnel should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M03 §3.2.4; CHAMGAP adaptation; Material collection/selection principles in M04 §4.5–4.6; Separating access from reading and defining hyperlink behavior are designed by CHAMGAP",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up research specifying masking and self-reported measurement; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The original text records quadruple masking and masking of several roles to assignment. Historical descriptions do not establish current verification of maintenance/unmasking or expectation effects on self-reports.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Original masking success/maintenance, unmasking, measurement/analysis roles and expectation effects remain unread. Existing content review remains incomplete.",
      "missingness": "Original masking success/maintenance, unmasking, measurement/analysis roles and expectation effects remain unread.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original masking roles/maintenance and measurement/analysis materials"
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Self-reported ARI definition",
      "needed": "Self-report, symptoms, diagnostic confirmation and first/repeated infections",
      "role": "Required",
      "role_reason": "An application item distinguishing Self-report, symptoms, diagnostic confirmation and first/repeated infections to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Self-report, symptoms, diagnostic confirmation and first/repeated infections should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M08 Table 8.2.a, M03 §3.2.4; internal application; M08 §8.2.2, M15 §15.3.1; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up research separating self-reports from confirmed infections; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "One selected indicator is self-reported acute respiratory infection. It is not converted to test/clinician-confirmed other-pathogen infection, PCR COVID-19 or serious outcomes.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Symptom/question definitions, recall/report windows, medical/test confirmation and first/repeated-event handling remain unverified. Existing content review remains incomplete.",
      "missingness": "Symptom/question definitions, recall/report windows, medical/test confirmation and first/repeated-event handling remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Self-reported ARI definitions, questionnaires/adjudication and event-handling data"
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Self-reported ARI counts and RR",
      "needed": "Original counts/effects/CI and exact units/denominators",
      "role": "Required",
      "role_reason": "An application item distinguishing Original counts/effects/CI and exact units/denominators to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Original counts/effects/CI and exact units/denominators should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are internally designed; M15 §15.3.1–15.3.3; internal application; M08 §8.2.2, M15 §15.3.1; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research disclosing units/denominators together with effects; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original self-reported ARI was 3,964 versus 3,834, RR 1.04 (0.97–1.11). No new proportions/absolute differences/CI or symptom-day/event totals are calculated.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Whether counts concern people/first/repeated events, effective denominators, adjustments/models and exact P values remain unverified. Existing content review remains incomplete.",
      "missingness": "Whether counts concern people/first/repeated events, effective denominators, adjustments/models and exact P values remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "ARI result tables, units/denominators and model/CI materials"
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Negative SARS-CoV-2 test indicator",
      "needed": "Negative tests versus ARI/other-pathogen confirmation",
      "role": "Required",
      "role_reason": "An application item distinguishing Negative tests versus ARI/other-pathogen confirmation to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Negative tests versus ARI/other-pathogen confirmation should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M08 Table 8.2.a, M03 §3.2.4; internal application; M08 §8.2.2, M15 §15.3.1; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up research separating negative tests from actual ARI confirmation; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Negative SARS-CoV-2 tests were a separate coprimary indicator: 8,546 versus 8,565, RR 1.00 (0.97–1.04). They are not treated as other-pathogen diagnoses or the same outcome as self-reported ARI.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Testing populations/reasons, units/repetition, test types, accompanying symptoms and other-pathogen confirmation remain unverified. Existing content review remains incomplete.",
      "missingness": "Testing populations/reasons, units/repetition, test types, accompanying symptoms and other-pathogen confirmation remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Negative-test definitions and testing/symptom/confirmation materials"
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Testing selection and confirmed-ARI gaps",
      "needed": "Self-report/testing and confirmed/unconfirmed infection scope",
      "role": "Required",
      "role_reason": "An application item distinguishing Self-report/testing and confirmed/unconfirmed infection scope to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Self-report/testing and confirmed/unconfirmed infection scope should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M03 §3.2.4; own application; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is independently designed; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is independently designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research separating self-report/testing selection from confirmed results; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original materials record negative tests and self-reported ARI separately. The indicators are not combined into new clinician/pathogen-confirmed ARI counts.",
      "condition_status": "Unverified",
      "status_reason": "Required current information remains unverified in the preserved summary. Testing/reporting flow, symptom/test timing, sensitivity/adjudication and separate confirmed non-COVID ARI results remain unverified. Existing content review remains incomplete.",
      "missingness": "Testing/reporting flow, symptom/test timing, sensitivity/adjudication and separate confirmed non-COVID ARI results remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Testing/reporting flow and confirmed-ARI definitions/results"
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "PCR COVID-19 is a related outcome",
      "needed": "PCR-confirmed COVID-19 versus other ARI endpoints",
      "role": "Required",
      "role_reason": "An application item distinguishing PCR-confirmed COVID-19 versus other ARI endpoints to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for PCR-confirmed COVID-19 versus other ARI endpoints should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M04 §4.6.1–4.6.2 distinguishes studies from reports; cohort/outcome links are an internal application; M15 §15.3.1–15.3.3; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up research reporting related endpoints separately; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original PCR infection was 227 versus 228, RR 1.00 (adjusted 95% CI 0.82–1.22). This is not transferred to events/effects for self-reported ARI or negative tests.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Specific PCR tests/denominators/models and ARI overlap/exclusion remain unverified. Existing content review remains incomplete.",
      "missingness": "Specific PCR tests/denominators/models and ARI overlap/exclusion remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "PCR/ARI definitions, overlap/denominators and models"
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Serious COVID-19 is a related outcome",
      "needed": "Serious-outcome definitions/events/ratios versus other ARI",
      "role": "Required",
      "role_reason": "An application item distinguishing Serious-outcome definitions/events/ratios versus other ARI to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Serious-outcome definitions/events/ratios versus other ARI should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M04 §4.6.1–4.6.2 distinguishes studies from reports; cohort/outcome links are an internal application; M15 §15.3.1–15.3.3; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up research separating endpoint components/overlap; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original serious COVID-19 was 121 versus 101, RR 1.20 (0.87–1.65). Do not combine this as selected ARI severity/effects or all infection events.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Serious components/adjudication, effective denominators, overlap/models and selected ARI severity remain unverified. Existing content review remains incomplete.",
      "missingness": "Serious components/adjudication, effective denominators, overlap/models and selected ARI severity remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Serious/PCR/ARI definitions, components/overlap and results"
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Four coprimary outcomes and fallback",
      "needed": "Coprimary outcomes/multiplicity, adjusted CI and prespecified hierarchy",
      "role": "Required",
      "role_reason": "An application item distinguishing Coprimary outcomes/multiplicity, adjusted CI and prespecified hierarchy to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Coprimary outcomes/multiplicity, adjusted CI and prespecified hierarchy should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M04 §4.6.3; internal application; M04 §4.6.3, M15 §15.3.1–15.3.3; status separation is internally designed; M04 §4.6.1–4.6.2 distinguishes studies from reports; cohort/outcome links are an internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up research specifying coprimary outcomes and adjusted results; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original descriptions of four coprimary endpoints, prespecified fallback multiplicity control and all-null findings are preserved. Each indicator is not turned into an independent trial or new success/exactly-zero-effect verdict for a single subclaim.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Fallback rules/order, full adjustment/testing specifications and SAP/amendments remain unread. Existing content review remains incomplete.",
      "missingness": "Fallback rules/order, full adjustment/testing specifications and SAP/amendments remain unread.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original registration/protocol/SAP and multiplicity/CI materials"
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "34,601·17,278/17,323",
      "needed": "Randomized population versus indicator-specific observations/denominators",
      "role": "Required",
      "role_reason": "An application item distinguishing Randomized population versus indicator-specific observations/denominators to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Randomized population versus indicator-specific observations/denominators should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up research distinguishing recruitment/observation/analysis denominators; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original randomization of 34,601 adults and arm sizes 17,278/17,323 are preserved. They are not automatically filled in as every indicator’s observation/person/event denominator.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Indicator-specific effective/observed/at-risk denominators, repeated tests/reports and unobserved-data definitions remain unverified. Existing content review remains incomplete.",
      "missingness": "Indicator-specific effective/observed/at-risk denominators, repeated tests/reports and unobserved-data definitions remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Randomized/indicator-specific denominators and observation/report flow"
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "ITT and 0.05% key-variable missingness",
      "needed": "Analysis by assignment and variable-specific missingness/handling scope",
      "role": "Required",
      "role_reason": "An application item distinguishing Analysis by assignment and variable-specific missingness/handling scope to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Analysis by assignment and variable-specific missingness/handling scope should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are internally designed; M08 §8.2.2, M15 §15.3.1; internal application; M04 §4.5–4.6 collection/selection principles; access/reading separation and hyperlink specifications are internally designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research reporting differences between variable-specific observation and ITT estimation; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original ITT for all randomized participants and 0.05% key-variable missingness are preserved. They do not verify no missingness or complete observation for every questionnaire/test/symptom-day outcome.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Variable/arm/period-specific missingness, handling/models, follow-up/sensitivity and actual original text remain unread. Existing content review remains incomplete.",
      "missingness": "Variable/arm/period-specific missingness, handling/models, follow-up/sensitivity and actual original text remain unread.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Variable-specific missingness, analysis populations and handling/sensitivity data"
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "People, symptom days, repetitions and tests",
      "needed": "Outcome units and repetition/time overlap handling",
      "role": "Required",
      "role_reason": "An application item distinguishing Outcome units and repetition/time overlap handling to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Outcome units and repetition/time overlap handling should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2 distinguishes studies from reports; cohort/outcome links are an internal application; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are internally designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research separately reporting people/events/days/test units; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The four original counts/indicators are preserved separately. People, infection episodes, symptom days, tests and related sheets are not counted as new participant/event/independent-trial totals.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. First/all/repeated-event definitions, symptom days, individual overlap and period-specific observation/time remain unverified. Existing content review remains incomplete.",
      "missingness": "First/all/repeated-event definitions, symptom days, individual overlap and period-specific observation/time remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Indicator-specific units/repetition, time and overlap data"
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Actual intake and concurrent exposures",
      "needed": "Original exposure/duration versus adherence, vitamins and behaviour/testing differences",
      "role": "Required",
      "role_reason": "An application item distinguishing Original exposure/duration versus adherence, vitamins and behaviour/testing differences to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Original exposure/duration versus adherence, vitamins and behaviour/testing differences should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M03 §3.2.3, M08 §8.2.2–8.2.3; own application; M03 §3.2.2–3.2.3; reverse-direction labels and test adaptations are our own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up research specifying actual exposure and concurrent conditions; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "5 mL/day and a median 164 days describe study exposure/duration. Actual complete intake or matching of concurrent vitamins/medications and lifestyle/prevention/testing conditions are not confirmed.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Adherence/discontinuation, additional supplements/medications, lifestyle/prevention, testing/contact and their analyses remain unverified. Existing content review remains incomplete.",
      "missingness": "Adherence/discontinuation, additional supplements/medications, lifestyle/prevention, testing/contact and their analyses remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual exposure, adherence/discontinuation and concurrent-condition data"
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Between-arm RR/CI and the scope of null findings",
      "needed": "Original relative effects/adjusted CI, within/between-arm and zero/equivalence distinctions",
      "role": "Required",
      "role_reason": "An application item distinguishing Original relative effects/adjusted CI, within/between-arm and zero/equivalence distinctions to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Original relative effects/adjusted CI, within/between-arm and zero/equivalence distinctions should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M08 §8.2.2, M15 §15.3.1; internal application; M15 §15.3.1–15.3.3; internal application; M04 §4.6.3, M15 §15.3.1–15.3.3; status separation is internally designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up research reporting effects/precision and applicability; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original ARI-related RRs/CI are retained. Within-arm symptom changes, RR near 1.00 or nonsignificance do not newly establish exactly zero effect, equivalence or absence of benefit/harm in every population.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Exact contrasts/models, adjustments, P, importance/equivalence criteria and indicator-specific estimation specifications remain unread. Existing content review remains incomplete.",
      "missingness": "Exact contrasts/models, adjustments, P, importance/equivalence criteria and indicator-specific estimation specifications remain unread.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Indicator-specific models, contrasts/CI and prespecified criteria"
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "NCT, prespecified dates and original plans",
      "needed": "Registration identifier/dates and preserved prespecified coprimary scope",
      "role": "Required",
      "role_reason": "An application item distinguishing Registration identifier/dates and preserved prespecified coprimary scope to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Registration identifier/dates and preserved prespecified coprimary scope should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M04 §4.6.3; custom application; M04 §4.5–4.6 material-collection/selection principles; separation of access/reading and hyperlink conventions are custom design; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research linking and disclosing prespecified coprimary outcomes and actual analysis; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original NCT04609423, posted 2020-10-30 and started 2020-11-10, are retained. Prospective/matching-coprimary descriptions are not upgraded to current full registration/plan verification.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Registration amendments, protocol/SAP and full indicator definition/testing/plans remain unread. Existing content review remains incomplete.",
      "missingness": "Registration amendments, protocol/SAP and full indicator definition/testing/plans remain unread.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Registration history, protocol, and SAP"
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Manufacturer funding and products/placebo",
      "needed": "Orkla support items/roles and product identity",
      "role": "Required",
      "role_reason": "An application item distinguishing Orkla support items/roles and product identity to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Orkla support items/roles and product identity should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "Chamgap’s own independence/attribution conditions. Official methodological sections used in this pilot do not guarantee every detailed item; M03 §3.2.2–3.2.3; reverse-direction labels and testing adaptations are internally designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up trial disclosing support/research roles; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Möller’s Tran manufacturer Orkla Health AS supplied funding, cod liver oil and placebo. Original context of a large null report for its own product is retained; funding alone does not yield a new independence/effect verdict.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Contracts, design/analysis/data/publication authority, original support text and full product/batch details remain unread. Existing content review remains incomplete.",
      "missingness": "Contracts, design/analysis/data/publication authority, original support text and full product/batch details remain unread.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Funding, product/placebo supply and role disclosures"
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "University/hospital and other support",
      "needed": "Oslo institutional support and item-specific roles",
      "role": "Required",
      "role_reason": "An application item distinguishing Oslo institutional support and item-specific roles to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Oslo institutional support and item-specific roles should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "Chamgap's own conditions for independence and attribution. The official methodological sections used in this example do not validate every detail of these items.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research separately disclosing support items and roles; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original Oslo University Hospital/University of Oslo support is retained. Public/university support does not replace manufacturer support or establish absence of all other support/COI.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Cash/in-kind support, institutional roles, external analysis/medical writing/publication costs and full support disclosures remain unread. Existing content review remains incomplete.",
      "missingness": "Cash/in-kind support, institutional roles, external analysis/medical writing/publication costs and full support disclosures remain unread.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Institutional/other support and role/writing/publication disclosures"
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Outside relationships and employee authors",
      "needed": "KBH/SMU outside relationships and AS/KTK affiliation scope",
      "role": "Required",
      "role_reason": "An application item distinguishing KBH/SMU outside relationships and AS/KTK affiliation scope to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for KBH/SMU outside relationships and AS/KTK affiliation scope should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "Chamgap’s own independence/attribution conditions. Official methodological sections used in this pilot do not guarantee every detailed item; M04 §4.5, §4.6.3; current material-conversion limits follow review scope and internal design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research distinguishing and disclosing relationships inside/outside the study and roles; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original KBH relationships with Olympic Seafood/Amgen/Sanofi, SMU with Olympic Seafood outside this study, and AS/KTK employment at Age Laboratories AS are retained. They are not converted to the same relationship as trial funding/product supply.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Relationships/contributions, contemporaneous contracts, diagnostic/analysis/data/publication roles and full COI disclosures remain unread. Existing content review remains incomplete.",
      "missingness": "Relationships/contributions, contemporaneous contracts, diagnostic/analysis/data/publication roles and full COI disclosures remain unread.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original author affiliations/contributions and outside relationships/COI"
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "One trial, four indicators and related sheets",
      "needed": "Report→cohort→indicator/time links and independent replication",
      "role": "Required",
      "role_reason": "An application item distinguishing Report→cohort→indicator/time links and independent replication to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Report→cohort→indicator/time links and independent replication should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "Study/report distinction in M04 §4.6.1–4.6.2; Cohort/outcome linkage is Chamgap application; M04 §4.6.1–4.6.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposal for later independent comparative research on the same selected question; no new investigation, calculation or trial was performed in that production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "S01 Brunvoll 2022 concerns the same trial of 34,601 adults. Four coprimary indicators, people/tests/time points, citations/registration and related sheets are not added as new independent trials/participants.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Independent replication matching formulation/population/ARI specifications and unique clinical totals are not established. Existing content review remains incomplete.",
      "missingness": "Independent replication matching formulation/population/ARI specifications and unique clinical totals are not established.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report/cohort/registration relationships and separate original studies"
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Deficiency, high dose, ingredients and long-term scope",
      "needed": "Winter combination product versus other ingredient/treatment/duration applications",
      "role": "Required",
      "role_reason": "An application item distinguishing Winter combination product versus other ingredient/treatment/duration applications to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Winter combination product versus other ingredient/treatment/duration applications should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M03 §3.2.1–3.2.4; dose/duration/effect-modification details are internally designed; M03 §3.2.2–3.2.3; reverse-direction labels and testing adaptations are internally designed; M03 §3.2.4; internal extension boundaries",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research distinguishing combination product from other application specifications; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The original verdict does not address deficiency treatment, high-dose vitamin D or omega-3 alone. A null combination product is not transferred to direct verdicts for those conditions/other seasons/long-term outcomes or to intake/treatment guidance.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Direct comparisons for other formulations/exposures/populations, persistence afterwards and clinical outcomes remain unverified. Existing content review remains incomplete.",
      "missingness": "Direct comparisons for other formulations/exposures/populations, persistence afterwards and clinical outcomes remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct formulation/population/duration-specific trials and follow-up data"
    },
    {
      "item_id": "N27",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "Original safety record and low-grade reporting",
      "needed": "Low-grade side effects, arm-specific frequencies/denominators and long-term harms",
      "role": "Supplementary",
      "role_reason": "An application item distinguishing Low-grade side effects, arm-specific frequencies/denominators and long-term harms to connect materials needed for the selected question with available materials.",
      "application_exception": "Supplements safety-information gaps for the selected subclaim. ARI/test/PCR/serious results or parent safety wording do not yield safety verdicts, harm incidence or new use instructions.",
      "criterion": "Relevant originals and analysis scope for Low-grade side effects, arm-specific frequencies/denominators and long-term harms should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M19 §19.1.2–19.2.4; detailed distinctions are Chamgap’s own design; M19 §19.1.2–19.2.4; Chamgap application; M19 §19.1.2–19.2.4; Chamgap application; M19 §19.1.2–19.2.4; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research specifying harm collection/scope and follow-up; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original parent good safety and low-grade side effects in both arms are retained. Scope is limited to tested dose/participants; rare/long-term harms or other-product safety are not verified.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Types/frequencies/denominators, collection/adjudication, discontinuation/causality and long-term/vulnerable-population harms remain unverified. Existing content review remains incomplete.",
      "missingness": "Types/frequencies/denominators, collection/adjudication, discontinuation/causality and long-term/vulnerable-population harms remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Safety collection, adverse-event/discontinuation and long-term follow-up data"
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Original axes, bilingual text, dates and history",
      "needed": "Original parent/subclaim values, axes, corrections and historical verification",
      "role": "Required",
      "role_reason": "An application item distinguishing Original parent/subclaim values, axes, corrections and historical verification to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Original parent/subclaim values, axes, corrections and historical verification should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design; M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research distinguishing original values/history from new-update scope; no new investigation, calculation or trial was performed in this production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Parent D with 34 points, B/H/R1/I0/E0/B0/C0, true large-hard-endpoint-RCT and two false indicators, empty override reasons and subclaim D/note are preserved. Bilingual text, 2026-08-26, empty corrections/deliberation and cross-checking are not inherited as completed clinical review now or subclaim scores.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. Absent subclaim score/status/axes are not filled with parent values; no new coprimary/method certification. Existing content review remains incomplete.",
      "missingness": "Absent subclaim score/status/axes are not filled with parent values; no new coprimary/method certification.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original corrections, versions and user correction comments"
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "Actual summary reading, links and gaps",
      "needed": "Reading preserved summaries versus external text/registration/plan access",
      "role": "Required",
      "role_reason": "An application item distinguishing Reading preserved summaries versus external text/registration/plan access to connect materials needed for the selected question with available materials.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant originals and analysis scope for Reading preserved summaries versus external text/registration/plan access should be available, with unverified items distinguished. Preserved wording is linked here; existing content review remains incomplete.",
      "basis": "M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposal for updating while distinguishing actual acquisition/timing/scope; no new investigation, calculation or trial was performed in that production.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The full preserved summary/citations were used for production and links retained. Original papers/registration/protocol/SAP/support/COI materials remain unread, access unattempted and external links untested.",
      "condition_status": "Partly verified",
      "status_reason": "Only relevant preserved-summary information is recorded; detailed originals remain unread and existing content review incomplete. External original content, exact definitions/denominators/models and accessibility remain unverified. Existing content review remains incomplete.",
      "missingness": "External original content, exact definitions/denominators/models and accessibility remain unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original paper, registration, protocol, SAP and support materials or user comments"
    }
  ],
  "reports": [
    {
      "report_id": "S01",
      "title": "Brunvoll SH et al. 2022",
      "url": "https://pubmed.ncbi.nlm.nih.gov/36215222/",
      "report_type": "Quadruple-blinded randomized placebo-controlled trial",
      "existence": "Stored bibliography exists; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "study_family": "RG2972-BRUNVOLL-2022",
      "independent_replication": null,
      "observed_result": "227 vs 228, RR 1.00 (0.82–1.22); 121 vs 101, RR 1.20 (0.87–1.65); 8,546 vs 8,565, RR 1.00 (0.97–1.04); 3,964 vs 3,834, RR 1.04 (0.97–1.11)",
      "result_level": "Outcome wording in the stored summary",
      "source_evidence_date": "2026-08-26",
      "materials": [
        {
          "material_type": "Stored summary",
          "public_status": "Stored file",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-08-26",
          "qualification": "Only stored-summary and bibliographic content was used for production. External material verification/review is not complete."
        },
        {
          "material_type": "External paper",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Registration material",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Protocol",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Statistical analysis plan",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Funding, product-support and COI material",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/36215222/"
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      ]
    }
  ],
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    }
  ],
  "status_dictionary": {
    "Met": "Status for necessary evidence confirmed after existing content review. No completion is declared in the current presentation.",
    "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.",
    "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.",
    "Review incomplete": "Existing content review remains incomplete.",
    "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.",
    "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.",
    "Not applicable": "Not used as a substitute for an evidence gap.",
    "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.",
    "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade."
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "S01 Brunvoll 2022 reports a quadruple-blinded winter trial in 34,601 Norwegian adults (17,278/17,323) not routinely taking vitamin D daily, comparing cod liver oil 5 mL/day with flavour-matched corn oil. Median 164 days/about six months, four coprimary outcomes/fallback/ITT and 0.05% key-variable missingness are original descriptions. Selected ARI-related negative tests 8,546/8,565, RR 1.00 (0.97–1.04), are distinguished from self-reports 3,964/3,834, RR 1.04 (0.97–1.11); negative tests are not converted to other-pathogen/clinician-confirmed infection. PCR 227/228, RR 1.00 (0.82–1.22), and serious outcomes 121/101, RR 1.20 (0.87–1.65), remain separate related endpoints. Combination-product vitamin D 10 µg/about 1 g n-3 is not repurposed as single-ingredient/deficiency-treatment/high-dose effects. People, arms, tests, events, time points, citations/registration and related sheets are not added as new independent trials/participants. Report-item counts are not unique clinical totals; no new calculations, independence certification or implementation guidance."
  },
  "history": [
    {
      "date": "2026-10-14",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "Public pages and materials were created from the existing 29 items. No new clinical search, verification-status change or scoring was performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-14"
}