Isopropyl-alcohol pad × Actual vomiting and treatment of the underlying cause—separate from short-term nausea

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionWhich vomiting or underlying-cause claim is assessed?Required	The stored assessment grades actual vomiting and treatment of the underlying disease D. It describes vomiting as sparsely assessed and null, and says the endpoint did not assess treatment of the cause. C54 belongs to the separate short-term nausea assessment. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Separate assessment of actual vomiting and treatment of the underlying disease	Material needed: Original data directly comparing vomiting events and cause-specific treatment or clinical outcomes are needed. This records needed materials; no new research was executed.
2	Partly verified	Full text not readStored summary read	N02 · Evidence conditionAre nausea scores, actual vomiting and treatment of the cause the same outcome?Required	The 10-minute nausea NRS measures a perceived symptom. Actual vomiting events and treatment of the underlying disease are separate; the stored explanation does not extend the short-term symptom signal to those outcomes. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Distinguishing symptom scores, vomiting events and underlying-disease outcomes	Material needed: Definitions, collection methods, times, denominators and direct between-group estimates and CIs are needed for each outcome. This records needed materials; no new research was executed.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionHas the ancillary trial that assessed vomiting been identified?Required	The stored explanation says vomiting was assessed in only one ancillary trial and was null. The trial identity, vomiting counts, denominators, times and CIs are not linked, so it is not assigned to Beadle or Candemir. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Identity and direct relevance of the original vomiting trial	Material needed: The trial authors, registration details, methods, original vomiting results and the review extraction table are needed. This records needed materials; no new research was executed.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionDoes a null vomiting result mean effect 0 or equivalence?Required	The stored wording concerns a null finding in a limited assessment of vomiting. Original event counts, affected people, denominators and CIs are unavailable, so it does not establish effect 0 or a precise absence of difference. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Distinguishing a limited null result from precision	Material needed: Vomiting definitions, events, affected people, group denominators, estimates, CIs, tests and equivalence margins are needed. This records needed materials; no new research was executed.
5	Unverified	Full text not readStored summary read	N05 · Evidence conditionCan vomiting episodes, affected people and observation time be distinguished?Required	The stored material only says vomiting was sparsely assessed; it gives no numbers identifying event counts or the proportion of affected people. The 10-minute and 30-minute nausea measurements are not used as vomiting observation times. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Events, people, observation windows and risk denominators	Material needed: Repeated episodes, affected people, group denominators, observation windows, post-rescue events, missingness and early-departure definitions are needed. This records needed materials; no new research was executed.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionAre Beadle's results direct evidence for treating actual vomiting?Required	Beadle's endpoints are the 10-minute nausea NRS, satisfaction and rescue antiemetic use. Median 3 versus 6, difference 3 with CI 2–4, satisfaction +2 and null rescue use are not converted into vomiting reduction or treatment of the underlying cause. R01	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Distinguishing nausea NRS, satisfaction and rescue medication from vomiting	Material needed: The full text and endpoint-specific tables are needed to establish whether vomiting or underlying-disease endpoints were included. Outcomes omitted from a summary are not declared unreported or absent. This records needed materials; no new research was executed.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionDoes Candemir's lower rescue-treatment use mean less vomiting?Required	The stored results concern NRS at 2, 4 and 10 minutes, rescue treatment, an overall between-group effect from 2 minutes with P=.008, and reduced rescue treatment. Rescue treatment may depend on clinicians' decisions and criteria, so it is not treated as the same endpoint as fewer vomiting events. R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Distinguishing rescue criteria, nausea scores and vomiting events	Material needed: Rescue criteria, drug types, times, denominators, original effects, CIs and vomiting-outcome collection data are needed. This records needed materials; no new research was executed.
8	Partly verified	Full text not readStored summary read	N08 · Evidence conditionDo different rescue-medication results show treatment of the cause?Required	Beadle's null rescue-medication result and Candemir's reduction in rescue treatment are retained separately. Results from different trials are not combined to conclude that the need to treat the underlying disease decreased. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause	Material needed: Rescue criteria and drugs, concurrent care, cause-specific treatment, diagnosis, fluids, admission outcomes and analysis denominators are needed. This records needed materials; no new research was executed.
9	Partly verified	Full text not readStored summary read	N09 · Evidence conditionIs a review's endpoint list the same as its actual vomiting results?Required	April lists nausea scores, vomiting, rescue medication and adverse events among its endpoints. The stored MD -2.18/10 and CI concern nausea scores; they are not used as vomiting event counts or effects. R03	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	April's vomiting, rescue and adverse-event list versus quantitative results	Material needed: Endpoint-specific included trials, extraction tables, times, events, affected people, denominators, effects, CIs and certainty data are needed. This records needed materials; no new research was executed.
10	Partly verified	Full text not readStored summary read	N10 · Evidence conditionDo the 30-minute 3-arm VAS results show effects on vomiting or its cause?Required	In the stored Korean account of the 120-person 3-arm trial, 30-minute VAS reductions of 30mm, 32mm and 9mm are within-group nausea changes. Ondansetron co-treatment and the different comparators are distinguished; the values are not converted into vomiting events or underlying-disease outcomes. R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Within-group nausea change and concomitant medication in NCT02760069	Material needed: The full text, vomiting and clinical endpoints, co-treatment, rescue, denominators and direct between-group effects and CIs are needed. Within-group values are not used to create between-group CIs or NRS or vomiting values. This records needed materials; no new research was executed.
11	Partly verified	Full text not readStored summary read	N11 · Evidence conditionAre direct results for diagnosis or treatment of the underlying disease available?Required	The stored explanation says there is no evidence of reduced need for emergency-department diagnosis, treatment of the cause or fluids. Original values and denominators for cause-specific diagnostic or treatment outcomes are not supplied. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Cause-specific diagnosis, treatment response and important clinical outcomes	Material needed: Direct comparisons of cause-specific eligibility, diagnosis, treatment, recovery, deterioration and important clinical outcomes are needed. Unverified direct data are not expanded into a claim that all research or effects are absent. This records needed materials; no new research was executed.
12	Unverified	Full text not readStored summary read	N12 · Evidence conditionDo satisfaction or symptom improvements mean less need for fluids or care?Required	Satisfaction +2 and the 10-minute NRS difference are their respective symptom or satisfaction outcomes. The stored material has no direct effect estimates for reduced fluids, care, admission or treatment of the cause. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Distinguishing satisfaction, care, fluids and clinical course	Material needed: Definitions of care, fluids, admission and discharge outcomes, decision criteria, concurrent treatment, group denominators, effects and CIs are needed. This records needed materials; no new research was executed.
13	Partly verified	Full text not readStored summary read	N13 · Evidence conditionHow do null vomiting results differ from unproven sustained effects?Required	The stored explanation describes vomiting and sustained effects as unproven. The 10-minute and separate 30-minute symptom data do not guarantee recurrence prevention, treatment of persistent vomiting or the longer-term course of the underlying disease. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Distinguishing limited vomiting assessment from recurrence and longer-term course	Material needed: Direct data assessing vomiting windows, recurrence, return visits, persistence, treatment of the cause and recovery with longer follow-up and denominators are needed. This records needed materials; no new research was executed.
14	Partly verified	Full text not readStored summary read	N14 · Evidence conditionDoes this checklist provide new use or administration instructions?Supplementary	This table explains the stored intervention, safety warnings and efficacy limits. Nausea reductions are not turned into a substitute for antiemetics or diagnosis, or into new use or administration instructions. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	The boundary between stored evidence and use, administration or clinical guidance	Material needed: Actual guidelines and clinical decisions are separate in scope. This table provides no new steps, frequency, doses or cause-specific treatment recommendations. This records needed materials; no new research was executed.
15	Partly verified	Full text not readStored summary read	N15 · Evidence conditionWhich adults in the emergency department were studied?Required	The stored scope is acute nausea in adults in the emergency department. Its population account repeats Beadle's 84 recruited and 80 completed and the group numbers, but does not define all causes or eligibility criteria. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Eligibility, causes and baseline severity of acute nausea	Material needed: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. The findings are not extended to children, pregnancy or other settings. This records needed materials; no new research was executed.
16	Partly verified	Full text not readStored summary read	N16 · Evidence conditionWhich formulation and route were studied?Required	The stored intervention is brief inhalation using a 70% isopropyl-alcohol pad. The 70% is a concentration, not an inhaled amount, frequency or exposure dose. The record distinguishes ingestion and broad skin application. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	The intervention boundary and exposure information for the original 70% pad	Material needed: Product, manufacturing, pad capacity, exposure criteria and consistency across groups are needed. No new use or administration instructions are provided. This records needed materials; no new research was executed.
17	Partly verified	Full text not readStored summary read	N17 · Evidence conditionAre saline-odor controls and drug co-treatment comparisons the same?Required	Beadle compares alcohol with saline odor. The Korean account of NCT02760069 describes 120 people, 3 arms and ondansetron co-treatment. The comparators and results of the two comparisons are not used as the same effect. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Distinguishing comparators, co-treatment, rescue drugs and the effect of interest	Material needed: Original group interventions, concomitant antiemetics, allocation, rescue criteria, the effect of interest and direct between-group results are needed. This records needed materials; no new research was executed.
18	Partly verified	Full text not readStored summary read	N18 · Evidence conditionAre recruitment, completion, ITT and outcome denominators the same?Required	Beadle reports 84 recruited and 80 completed, with 37 alcohol and 43 saline; the Korean account describes 80 analysed. Candemir reports 118 ITT and 115 completed. The separate 120-person 3-arm trial and the review's 195 people are different contexts. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Trial-specific allocation, completion and analysis denominators	Material needed: Recruitment, allocation, completion, time-specific assessment and analysis flow, group missingness, withdrawals and ITT definitions are needed. Differences, participants and reports are not newly calculated or summed. This records needed materials; no new research was executed.
19	Partly verified	Full text not readStored summary read	N19 · Evidence conditionCould odor have made blinding incomplete?Required	The stored counterview and citation record incomplete blinding due to odor. The label randomized trial alone does not establish adequate blinding of subjective nausea assessments and assessors. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Allocation, concealment, subjective measurement and expectancy	Material needed: Allocation, concealment, who was blinded, blinding-success assessment, NRS collectors and procedures, withdrawals and revealing cues are needed. No new formal RoB2 assessment is made. This records needed materials; no new research was executed.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionHave trial registrations and review registrations actually been read?Required	NCT02092441 appears in the stored evidence and citation, and NCT02760069 in the Korean account. Candemir's registration is unverified. CRD42022299815 identifies April's review registration, not a clinical trial registration. No external registration or plan was read in this work. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Distinguishing trial and review registration from prospective plans	Material needed: Original registrations, amendments, protocols, SAPs and prospective endpoints and denominators are needed separately for trials and reviews. An identifier alone is not verification of prospective specification. This records needed materials; no new research was executed.
21	Partly verified	Full text not readStored summary read	N21 · Evidence conditionAre company funding, product supply, affiliations and analysis roles separated?Required	The stored material describes Beadle as a military institutional study without manufacturer sponsorship, Candemir as reporting no conflict of interest with detailed funding unverified, and April as academic research without manufacturer involvement. Detailed funding for NCT02760069 is absent from the Korean account. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Different aspects of company involvement by report	Material needed: Separate documents on financial support, product support, company affiliations and design, analysis or publication roles are needed. Conflict-of-interest or sponsorship wording alone does not establish absence across every category. This records needed materials; no new research was executed.
22	Partly verified	Full text not readStored summary read	N22 · Evidence conditionAre reports and trials included in reviews counted twice?Required	The two subclaims share parent 3012's Beadle, Candemir and April records and the separate Korean 3-arm summary. April is a review including original trials, and the Korean account of 120 people is not a separate evidence or citation entry. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Reports, original trials, participants and shared relationships	Material needed: Included-trial, time-specific analysis-population, report and cohort identification tables are needed. Reports, sheets and original numbers are not summed as unique trials, participants or independent replications. This records needed materials; no new research was executed.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionHas the stored description of independent replication been verified?Required	The stored assessment labels Candemir an independent replication while also describing its funding, registration and prospective specification as unclear. This historical wording is not converted into current verification of independence. R01 R02 R03	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Candemir's supportive result versus unverified funding and prospective specification	Material needed: Original registration, prospective plans, institutions, recruitment, support and overlapping-report relationships are needed. The number of unique independent trials is unverified. This records needed materials; no new research was executed.
24	Partly verified	Full text not readStored summary read	N24 · Evidence conditionAre the different Korean and English contexts distinguished?Required	The stored Korean explanation describes NCT02760069's 30-minute within-group VAS results. The English explanation contains the 10-minute meta-analysis of two placebo-controlled trials and 195 people. They are not substituted as translations of the same report, time or between-group effect. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	The Korean 30-minute 3-arm account versus the English pooled result	Material needed: Original trial and review tables, denominators, times and effects of interest need comparison. Both stored language accounts are retained without new external comparison or correction. This records needed materials; no new research was executed.
25	Partly verified	Full text not readStored summary read	N25 · Evidence conditionDoes reading a stored summary differ from reading external materials?Required	The complete stored assessment was read. Citation wording such as checked and cross-check incorporated describes historical work. External abstracts, full texts, registrations, protocols and SAPs remain unread in this work. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Reading scope for summaries, abstracts, full texts, registrations and plans	Material needed: Access and reading status need separate records when actual materials are obtained and reviewed. A URL alone does not establish full-text reading, accessibility or completed review. This records needed materials; no new research was executed.
26	Partly verified	Full text not readStored summary read	N26 · Evidence conditionAre adverse-event collection, denominators and exposure known?Supplementary	The stored safety account contains existing warnings about harms and emergency symptoms. April lists adverse events as an endpoint, but the summary lacks group event counts, collection methods, denominators and exposure. No new use or administration instructions are provided. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Harms such as dizziness, headache, cough and respiratory irritation	Material needed: Collection methods, events, affected people, severity, times, exposure, group denominators, discontinuation, rescue and causal-assessment data are needed. Missing numbers do not mean safe or harmless. This records needed materials; no new research was executed.
27	Partly verified	Full text not readStored summary read	N27 · Evidence conditionCan a brief trial establish repeated exposure, long-term use or vulnerable-group safety?Supplementary	The representative endpoint is 10 minutes, with a separate 30-minute Korean context. These are not extended to verification of safety for long-term or repeated exposure, pregnancy or respiratory vulnerability. The stored safety account is distinguished as existing warnings. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Brief observation versus long-term, rare harms and vulnerable populations	Material needed: Long-term or repeated exposure, vulnerable-group eligibility, group harm follow-up, denominators and actual exposure data are needed. No new research or searches were performed. This records needed materials; no new research was executed.
28	Partly verified	Full text not readStored summary read	N28 · Evidence conditionHow are subclaim grades C and D distinguished from parent C54?Required	The acute-nausea subclaim is C and the actual-vomiting or underlying-cause-treatment subclaim is D. Individual scores, statuses and axes are absent; parent C54, caution and B/P/R1/I2/E+/B2/CX belong to the overall nausea assessment. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	The selected grade versus the parent score, caution status and axes	Material needed: The boundary between subclaim and parent application must be distinguished. D is not replaced with C54, and no new subclaim score, harm grade or independence certification is created. This records needed materials; no new research was executed.
29	Partly verified	Full text not readStored summary read	N29 · Evidence conditionDid the change from draft B to final C happen in this work?Required	The stored decision history records draft B, final C, score 54 and cross-check incorporation. This is a historical decision, not a new reassessment from B to C in this work. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	The stored assessment's decision history versus the current record	Material needed: Any assessment change needs a separate record preserving the preceding text, event, version and reasons. This table retains stored values. This records needed materials; no new research was executed.
30	Partly verified	Full text not readStored summary read	N30 · Evidence conditionAre the evidence date, production time and corrections distinguished?Required	The original evidence date is 2026-09-07. Corrections are stored as an empty list and deliberation as an empty string. The production time is not turned into a new evidence-verification date, and no nonexistent correction is invented. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	The original evidence date and empty correction or deliberation records	Material needed: Evidence additions, condition revisions, observation applications and assessment changes must be distinguished, preserving the preceding text and reasons for change. This records needed materials; no new research was executed.

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30 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-09-07
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: Actual vomiting and treatment of the underlying disease are asked about separately within acute-nausea research in emergency-department adults. Causes, detailed eligibility, baseline severity and valid endpoint-specific denominators remain unverified. Findings are not extended to other populations or settings.
Ingredient, formulation and route: The original intervention is brief inhalation from a 70% isopropyl-alcohol pad. The recorded route is retained and distinguished from ingestion or broad skin application.
Dose: 70% is the original concentration. Actual inhaled quantity, frequency and quantitative exposure remain unverified; concentration is not converted into a dose, and no new procedure or administration guidance is created.
Comparator: Saline-odor control is central, while the separate 3-arm comparison, ondansetron combinations and rescue medication are distinguished.
Measured outcome: The selected question concerns actual vomiting events and treatment of the underlying disease. Direct data and detailed denominators remain unverified. The 10-minute nausea NRS, satisfaction, rescue medication and separate 30-minute VAS are not treated as the same outcomes.
Duration: The actual vomiting observation window and follow-up for treatment of the cause remain unverified. The 10-minute nausea or separate 30-minute symptom data are not substituted for those observation periods.
Questions outside this scope: Extending short-term subjective nausea to reduced actual vomiting, treatment of the cause, less care or fluids, or sustained effects; Creating new between-group effects, CIs or NRS conversions from 30-minute within-group VAS; Converting limited null vomiting findings into precise effect 0 or equivalence certification; Adding original trials, reviews, shared reports and sheets as unique trials, participants or independent replications; Creating new procedures, administration or individual-care guidance from original concentration, route or safety cautions

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

R01 · Beadle KL et al. 2016

PubMed

Material type: Randomized alcohol-versus-saline odor trial; principal 10-minute nausea NRS
Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.
Findings recorded in the stored summary: The record states 84 recruited, 80 completed, 37 alcohol and 43 saline. Original 10-minute medians of 3 versus 6, difference 3 (95% CI 2 to 4), satisfaction +2 and null rescue use are retained.
Record level: This is a stored summary of direct NRS findings. Recruitment, completion, analysis wording and endpoint-specific denominators are distinguished; historical registration and verification narratives are not promoted into current external verification. These nausea, satisfaction and rescue findings are not converted into direct results for actual vomiting or treatment of the cause.
Study overlap and independent replication: Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.

R02 · Candemir H et al. 2021

PubMed

Material type: Prospective randomized placebo-controlled trial; repeated-time nausea and rescue treatment
Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.
Findings recorded in the stored summary: The report records 118 in ITT, 115 completed, nausea NRS at 2, 4 and 10 minutes and rescue treatment. The overall between-group effect from 2 minutes, P=.008, and less rescue treatment are retained without copying identical effects or CIs to each time.
Record level: Original independent-replication wording is retained together with unverified specific funding, registration and prespecification. No current independence certification or confirmed unique-trial total is created. Less rescue treatment is not substituted as a direct estimate of fewer vomiting events or treatment of the underlying disease.
Study overlap and independent replication: Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.

R03 · April MD et al. 2023

PubMed

Material type: Systematic review and meta-analysis; quantitative synthesis of included trials
Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.
Findings recorded in the stored summary: The original record retains 2 saline-controlled RCTs, 195 participants, 10-minute MD -2.18/10 (95% CI -2.76 to -1.60), MCID 1.5 and moderate certainty.
Record level: These are the original review's criteria and certainty narratives. Externally validated important differences, extraction from included trials and overlap remain unverified; the review is not counted as a new original trial or current official GRADE assessment. Listed vomiting, rescue and adverse-event endpoints are distinguished from quantitative nausea results; the original vomiting results table is unread.
Study overlap and independent replication: Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.

R04 · Separate 3-arm summary in the stored Korean account

Material type: Korean context concerning NCT02760069; no separate evidence or bibliography entry
Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.
Findings recorded in the stored summary: The 120-person, 3-arm, 30-minute within-group VAS reductions are 30mm with alcohol, 32mm with ondansetron plus alcohol and 9mm with ondansetron plus saline. This remains separate Korean context without new between-group effects, CIs or NRS conversion.
Record level: This is preserved context from the parent Korean explanation. Detailed bibliography, an original-text URL, arm-specific analysis denominators and original between-group results are unlinked; no external link is newly inferred. These within-group nausea changes are distinguished from actual vomiting or treatment-of-cause outcomes.
Study overlap and independent replication: Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.

Report counts versus independent study counts

Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which vomiting or underlying-cause claim is assessed?

Required materials and conditions: Separate assessment of actual vomiting and treatment of the underlying disease
Conditions for verification: Original material on Separate assessment of actual vomiting and treatment of the underlying disease must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Separate assessment of actual vomiting and treatment of the underlying disease is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N02 · Are nausea scores, actual vomiting and treatment of the cause the same outcome?

Required materials and conditions: Distinguishing symptom scores, vomiting events and underlying-disease outcomes
Conditions for verification: Original material on Distinguishing symptom scores, vomiting events and underlying-disease outcomes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Distinguishing symptom scores, vomiting events and underlying-disease outcomes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N03 · Has the ancillary trial that assessed vomiting been identified?

Required materials and conditions: Identity and direct relevance of the original vomiting trial
Conditions for verification: Original material on Identity and direct relevance of the original vomiting trial must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Identity and direct relevance of the original vomiting trial is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N04 · Does a null vomiting result mean effect 0 or equivalence?

Required materials and conditions: Distinguishing a limited null result from precision
Conditions for verification: Original material on Distinguishing a limited null result from precision must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Distinguishing a limited null result from precision is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N05 · Can vomiting episodes, affected people and observation time be distinguished?

Required materials and conditions: Events, people, observation windows and risk denominators
Conditions for verification: Original material on Events, people, observation windows and risk denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Events, people, observation windows and risk denominators is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N06 · Are Beadle's results direct evidence for treating actual vomiting?

Required materials and conditions: Distinguishing nausea NRS, satisfaction and rescue medication from vomiting
Conditions for verification: Original material on Distinguishing nausea NRS, satisfaction and rescue medication from vomiting must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Distinguishing nausea NRS, satisfaction and rescue medication from vomiting is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N07 · Does Candemir's lower rescue-treatment use mean less vomiting?

Required materials and conditions: Distinguishing rescue criteria, nausea scores and vomiting events
Conditions for verification: Original material on Distinguishing rescue criteria, nausea scores and vomiting events must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Distinguishing rescue criteria, nausea scores and vomiting events is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N08 · Do different rescue-medication results show treatment of the cause?

Required materials and conditions: Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause
Conditions for verification: Original material on Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N09 · Is a review's endpoint list the same as its actual vomiting results?

Required materials and conditions: April's vomiting, rescue and adverse-event list versus quantitative results
Conditions for verification: Original material on April's vomiting, rescue and adverse-event list versus quantitative results must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on April's vomiting, rescue and adverse-event list versus quantitative results is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N10 · Do the 30-minute 3-arm VAS results show effects on vomiting or its cause?

Required materials and conditions: Within-group nausea change and concomitant medication in NCT02760069
Conditions for verification: Original material on Within-group nausea change and concomitant medication in NCT02760069 must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Within-group nausea change and concomitant medication in NCT02760069 is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N11 · Are direct results for diagnosis or treatment of the underlying disease available?

Required materials and conditions: Cause-specific diagnosis, treatment response and important clinical outcomes
Conditions for verification: Original material on Cause-specific diagnosis, treatment response and important clinical outcomes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Cause-specific diagnosis, treatment response and important clinical outcomes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N12 · Do satisfaction or symptom improvements mean less need for fluids or care?

Required materials and conditions: Distinguishing satisfaction, care, fluids and clinical course
Conditions for verification: Original material on Distinguishing satisfaction, care, fluids and clinical course must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Distinguishing satisfaction, care, fluids and clinical course is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N13 · How do null vomiting results differ from unproven sustained effects?

Required materials and conditions: Distinguishing limited vomiting assessment from recurrence and longer-term course
Conditions for verification: Original material on Distinguishing limited vomiting assessment from recurrence and longer-term course must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Distinguishing limited vomiting assessment from recurrence and longer-term course is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N14 · Does this checklist provide new use or administration instructions?

Required materials and conditions: The boundary between stored evidence and use, administration or clinical guidance
Conditions for verification: Original material on The boundary between stored evidence and use, administration or clinical guidance must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Supplementary
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on The boundary between stored evidence and use, administration or clinical guidance is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N15 · Which adults in the emergency department were studied?

Required materials and conditions: Eligibility, causes and baseline severity of acute nausea
Conditions for verification: Original material on Eligibility, causes and baseline severity of acute nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Eligibility, causes and baseline severity of acute nausea is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N16 · Which formulation and route were studied?

Required materials and conditions: The intervention boundary and exposure information for the original 70% pad
Conditions for verification: Original material on The intervention boundary and exposure information for the original 70% pad must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on The intervention boundary and exposure information for the original 70% pad is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N17 · Are saline-odor controls and drug co-treatment comparisons the same?

Required materials and conditions: Distinguishing comparators, co-treatment, rescue drugs and the effect of interest
Conditions for verification: Original material on Distinguishing comparators, co-treatment, rescue drugs and the effect of interest must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Distinguishing comparators, co-treatment, rescue drugs and the effect of interest is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N18 · Are recruitment, completion, ITT and outcome denominators the same?

Required materials and conditions: Trial-specific allocation, completion and analysis denominators
Conditions for verification: Original material on Trial-specific allocation, completion and analysis denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Trial-specific allocation, completion and analysis denominators is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N19 · Could odor have made blinding incomplete?

Required materials and conditions: Allocation, concealment, subjective measurement and expectancy
Conditions for verification: Original material on Allocation, concealment, subjective measurement and expectancy must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Allocation, concealment, subjective measurement and expectancy is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N20 · Have trial registrations and review registrations actually been read?

Required materials and conditions: Distinguishing trial and review registration from prospective plans
Conditions for verification: Original material on Distinguishing trial and review registration from prospective plans must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Distinguishing trial and review registration from prospective plans is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N21 · Are company funding, product supply, affiliations and analysis roles separated?

Required materials and conditions: Different aspects of company involvement by report
Conditions for verification: Original material on Different aspects of company involvement by report must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Different aspects of company involvement by report is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N22 · Are reports and trials included in reviews counted twice?

Required materials and conditions: Reports, original trials, participants and shared relationships
Conditions for verification: Original material on Reports, original trials, participants and shared relationships must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Reports, original trials, participants and shared relationships is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N23 · Has the stored description of independent replication been verified?

Required materials and conditions: Candemir's supportive result versus unverified funding and prospective specification
Conditions for verification: Original material on Candemir's supportive result versus unverified funding and prospective specification must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Candemir's supportive result versus unverified funding and prospective specification is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N24 · Are the different Korean and English contexts distinguished?

Required materials and conditions: The Korean 30-minute 3-arm account versus the English pooled result
Conditions for verification: Original material on The Korean 30-minute 3-arm account versus the English pooled result must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on The Korean 30-minute 3-arm account versus the English pooled result is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N25 · Does reading a stored summary differ from reading external materials?

Required materials and conditions: Reading scope for summaries, abstracts, full texts, registrations and plans
Conditions for verification: Original material on Reading scope for summaries, abstracts, full texts, registrations and plans must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Reading scope for summaries, abstracts, full texts, registrations and plans is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N26 · Are adverse-event collection, denominators and exposure known?

Required materials and conditions: Harms such as dizziness, headache, cough and respiratory irritation
Conditions for verification: Original material on Harms such as dizziness, headache, cough and respiratory irritation must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Supplementary
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Harms such as dizziness, headache, cough and respiratory irritation is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N27 · Can a brief trial establish repeated exposure, long-term use or vulnerable-group safety?

Required materials and conditions: Brief observation versus long-term, rare harms and vulnerable populations
Conditions for verification: Original material on The boundary between brief observation and longer-term, rare harms or vulnerable groups must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Supplementary
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on The boundary between brief observation and longer-term, rare harms or vulnerable groups is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N28 · How are subclaim grades C and D distinguished from parent C54?

Required materials and conditions: The selected grade versus the parent score, caution status and axes
Conditions for verification: Original material on The selected grade versus the parent score, caution status and axes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on The selected grade versus the parent score, caution status and axes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N29 · Did the change from draft B to final C happen in this work?

Required materials and conditions: The stored assessment's decision history versus the current record
Conditions for verification: Original material on The stored assessment's decision history versus the current record must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on The stored assessment's decision history versus the current record is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N30 · Are the evidence date, production time and corrections distinguished?

Required materials and conditions: The original evidence date and empty correction or deliberation records
Conditions for verification: Original material on The original evidence date and empty correction or deliberation records must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on The original evidence date and empty correction or deliberation records is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

What the statuses mean

Partly verified: Partial information from the stored summary is linked; detailed originals and content review remain incomplete.
Unverified: Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.
Review incomplete: Review of existing content remains incomplete.
Met: This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.
Not reported: Unreported within material actually read. Unread external material is not relabeled as unreported.
Inaccessible: This means actual access failure. External access was not attempted in this work, so this state was not assigned.
Not applicable: Used only with an application exception and reason based on the question scope.
Conflicting data: This requires actual comparison of materials; no new conflict judgment was made in this work.
Insufficient evidence for the conditions: This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade.

Change history

2026-10-20 · Public page/material version 1.0

Public-facing views and materials were prepared from the existing 30 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-09-07) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which vomiting or underlying-cause claim is assessed?

Current findings: The stored assessment grades actual vomiting and treatment of the underlying disease D. It describes vomiting as sparsely assessed and null, and says the endpoint did not assess treatment of the cause. C54 belongs to the separate short-term nausea assessment.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original data directly comparing vomiting events and cause-specific treatment or clinical outcomes are needed.
Required materials and conditions: Separate assessment of actual vomiting and treatment of the underlying disease
Materials to obtain first: Original data directly comparing vomiting events and cause-specific treatment or clinical outcomes are needed.
Further research: Material needed: Original data directly comparing vomiting events and cause-specific treatment or clinical outcomes are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Separate assessment of actual vomiting and treatment of the underlying disease must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Separate assessment of actual vomiting and treatment of the underlying disease is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N02 · Are nausea scores, actual vomiting and treatment of the cause the same outcome?

Current findings: The 10-minute nausea NRS measures a perceived symptom. Actual vomiting events and treatment of the underlying disease are separate; the stored explanation does not extend the short-term symptom signal to those outcomes.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Definitions, collection methods, times, denominators and direct between-group estimates and CIs are needed for each outcome.
Required materials and conditions: Distinguishing symptom scores, vomiting events and underlying-disease outcomes
Materials to obtain first: Definitions, collection methods, times, denominators and direct between-group estimates and CIs are needed for each outcome.
Further research: Material needed: Definitions, collection methods, times, denominators and direct between-group estimates and CIs are needed for each outcome. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Distinguishing symptom scores, vomiting events and underlying-disease outcomes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Distinguishing symptom scores, vomiting events and underlying-disease outcomes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N03 · Has the ancillary trial that assessed vomiting been identified?

Current findings: The stored explanation says vomiting was assessed in only one ancillary trial and was null. The trial identity, vomiting counts, denominators, times and CIs are not linked, so it is not assigned to Beadle or Candemir.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: The trial authors, registration details, methods, original vomiting results and the review extraction table are needed.
Required materials and conditions: Identity and direct relevance of the original vomiting trial
Materials to obtain first: The trial authors, registration details, methods, original vomiting results and the review extraction table are needed.
Further research: Material needed: The trial authors, registration details, methods, original vomiting results and the review extraction table are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Identity and direct relevance of the original vomiting trial must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Identity and direct relevance of the original vomiting trial is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N04 · Does a null vomiting result mean effect 0 or equivalence?

Current findings: The stored wording concerns a null finding in a limited assessment of vomiting. Original event counts, affected people, denominators and CIs are unavailable, so it does not establish effect 0 or a precise absence of difference.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Vomiting definitions, events, affected people, group denominators, estimates, CIs, tests and equivalence margins are needed.
Required materials and conditions: Distinguishing a limited null result from precision
Materials to obtain first: Vomiting definitions, events, affected people, group denominators, estimates, CIs, tests and equivalence margins are needed.
Further research: Material needed: Vomiting definitions, events, affected people, group denominators, estimates, CIs, tests and equivalence margins are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Distinguishing a limited null result from precision must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Distinguishing a limited null result from precision is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N05 · Can vomiting episodes, affected people and observation time be distinguished?

Current findings: The stored material only says vomiting was sparsely assessed; it gives no numbers identifying event counts or the proportion of affected people. The 10-minute and 30-minute nausea measurements are not used as vomiting observation times.
Verification status: Unverified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Repeated episodes, affected people, group denominators, observation windows, post-rescue events, missingness and early-departure definitions are needed.
Required materials and conditions: Events, people, observation windows and risk denominators
Materials to obtain first: Repeated episodes, affected people, group denominators, observation windows, post-rescue events, missingness and early-departure definitions are needed.
Further research: Material needed: Repeated episodes, affected people, group denominators, observation windows, post-rescue events, missingness and early-departure definitions are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Events, people, observation windows and risk denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Events, people, observation windows and risk denominators is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N06 · Are Beadle's results direct evidence for treating actual vomiting?

Current findings: Beadle's endpoints are the 10-minute nausea NRS, satisfaction and rescue antiemetic use. Median 3 versus 6, difference 3 with CI 2–4, satisfaction +2 and null rescue use are not converted into vomiting reduction or treatment of the underlying cause.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: The full text and endpoint-specific tables are needed to establish whether vomiting or underlying-disease endpoints were included. Outcomes omitted from a summary are not declared unreported or absent.
Required materials and conditions: Distinguishing nausea NRS, satisfaction and rescue medication from vomiting
Materials to obtain first: The full text and endpoint-specific tables are needed to establish whether vomiting or underlying-disease endpoints were included. Outcomes omitted from a summary are not declared unreported or absent.
Further research: Material needed: The full text and endpoint-specific tables are needed to establish whether vomiting or underlying-disease endpoints were included. Outcomes omitted from a summary are not declared unreported or absent. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Distinguishing nausea NRS, satisfaction and rescue medication from vomiting must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Distinguishing nausea NRS, satisfaction and rescue medication from vomiting is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01

N07 · Does Candemir's lower rescue-treatment use mean less vomiting?

Current findings: The stored results concern NRS at 2, 4 and 10 minutes, rescue treatment, an overall between-group effect from 2 minutes with P=.008, and reduced rescue treatment. Rescue treatment may depend on clinicians' decisions and criteria, so it is not treated as the same endpoint as fewer vomiting events.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Rescue criteria, drug types, times, denominators, original effects, CIs and vomiting-outcome collection data are needed.
Required materials and conditions: Distinguishing rescue criteria, nausea scores and vomiting events
Materials to obtain first: Rescue criteria, drug types, times, denominators, original effects, CIs and vomiting-outcome collection data are needed.
Further research: Material needed: Rescue criteria, drug types, times, denominators, original effects, CIs and vomiting-outcome collection data are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Distinguishing rescue criteria, nausea scores and vomiting events must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Distinguishing rescue criteria, nausea scores and vomiting events is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R02

N08 · Do different rescue-medication results show treatment of the cause?

Current findings: Beadle's null rescue-medication result and Candemir's reduction in rescue treatment are retained separately. Results from different trials are not combined to conclude that the need to treat the underlying disease decreased.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Rescue criteria and drugs, concurrent care, cause-specific treatment, diagnosis, fluids, admission outcomes and analysis denominators are needed.
Required materials and conditions: Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause
Materials to obtain first: Rescue criteria and drugs, concurrent care, cause-specific treatment, diagnosis, fluids, admission outcomes and analysis denominators are needed.
Further research: Material needed: Rescue criteria and drugs, concurrent care, cause-specific treatment, diagnosis, fluids, admission outcomes and analysis denominators are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N09 · Is a review's endpoint list the same as its actual vomiting results?

Current findings: April lists nausea scores, vomiting, rescue medication and adverse events among its endpoints. The stored MD -2.18/10 and CI concern nausea scores; they are not used as vomiting event counts or effects.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Endpoint-specific included trials, extraction tables, times, events, affected people, denominators, effects, CIs and certainty data are needed.
Required materials and conditions: April's vomiting, rescue and adverse-event list versus quantitative results
Materials to obtain first: Endpoint-specific included trials, extraction tables, times, events, affected people, denominators, effects, CIs and certainty data are needed.
Further research: Material needed: Endpoint-specific included trials, extraction tables, times, events, affected people, denominators, effects, CIs and certainty data are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on April's vomiting, rescue and adverse-event list versus quantitative results must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on April's vomiting, rescue and adverse-event list versus quantitative results is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R03

N10 · Do the 30-minute 3-arm VAS results show effects on vomiting or its cause?

Current findings: In the stored Korean account of the 120-person 3-arm trial, 30-minute VAS reductions of 30mm, 32mm and 9mm are within-group nausea changes. Ondansetron co-treatment and the different comparators are distinguished; the values are not converted into vomiting events or underlying-disease outcomes.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: The full text, vomiting and clinical endpoints, co-treatment, rescue, denominators and direct between-group effects and CIs are needed. Within-group values are not used to create between-group CIs or NRS or vomiting values.
Required materials and conditions: Within-group nausea change and concomitant medication in NCT02760069
Materials to obtain first: The full text, vomiting and clinical endpoints, co-treatment, rescue, denominators and direct between-group effects and CIs are needed. Within-group values are not used to create between-group CIs or NRS or vomiting values.
Further research: Material needed: The full text, vomiting and clinical endpoints, co-treatment, rescue, denominators and direct between-group effects and CIs are needed. Within-group values are not used to create between-group CIs or NRS or vomiting values. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Within-group nausea change and concomitant medication in NCT02760069 must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Within-group nausea change and concomitant medication in NCT02760069 is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R04

N11 · Are direct results for diagnosis or treatment of the underlying disease available?

Current findings: The stored explanation says there is no evidence of reduced need for emergency-department diagnosis, treatment of the cause or fluids. Original values and denominators for cause-specific diagnostic or treatment outcomes are not supplied.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Direct comparisons of cause-specific eligibility, diagnosis, treatment, recovery, deterioration and important clinical outcomes are needed. Unverified direct data are not expanded into a claim that all research or effects are absent.
Required materials and conditions: Cause-specific diagnosis, treatment response and important clinical outcomes
Materials to obtain first: Direct comparisons of cause-specific eligibility, diagnosis, treatment, recovery, deterioration and important clinical outcomes are needed. Unverified direct data are not expanded into a claim that all research or effects are absent.
Further research: Material needed: Direct comparisons of cause-specific eligibility, diagnosis, treatment, recovery, deterioration and important clinical outcomes are needed. Unverified direct data are not expanded into a claim that all research or effects are absent. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Cause-specific diagnosis, treatment response and important clinical outcomes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Cause-specific diagnosis, treatment response and important clinical outcomes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N12 · Do satisfaction or symptom improvements mean less need for fluids or care?

Current findings: Satisfaction +2 and the 10-minute NRS difference are their respective symptom or satisfaction outcomes. The stored material has no direct effect estimates for reduced fluids, care, admission or treatment of the cause.
Verification status: Unverified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Definitions of care, fluids, admission and discharge outcomes, decision criteria, concurrent treatment, group denominators, effects and CIs are needed.
Required materials and conditions: Distinguishing satisfaction, care, fluids and clinical course
Materials to obtain first: Definitions of care, fluids, admission and discharge outcomes, decision criteria, concurrent treatment, group denominators, effects and CIs are needed.
Further research: Material needed: Definitions of care, fluids, admission and discharge outcomes, decision criteria, concurrent treatment, group denominators, effects and CIs are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Distinguishing satisfaction, care, fluids and clinical course must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Distinguishing satisfaction, care, fluids and clinical course is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N13 · How do null vomiting results differ from unproven sustained effects?

Current findings: The stored explanation describes vomiting and sustained effects as unproven. The 10-minute and separate 30-minute symptom data do not guarantee recurrence prevention, treatment of persistent vomiting or the longer-term course of the underlying disease.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Direct data assessing vomiting windows, recurrence, return visits, persistence, treatment of the cause and recovery with longer follow-up and denominators are needed.
Required materials and conditions: Distinguishing limited vomiting assessment from recurrence and longer-term course
Materials to obtain first: Direct data assessing vomiting windows, recurrence, return visits, persistence, treatment of the cause and recovery with longer follow-up and denominators are needed.
Further research: Material needed: Direct data assessing vomiting windows, recurrence, return visits, persistence, treatment of the cause and recovery with longer follow-up and denominators are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Distinguishing limited vomiting assessment from recurrence and longer-term course must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Distinguishing limited vomiting assessment from recurrence and longer-term course is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N14 · Does this checklist provide new use or administration instructions?

Current findings: This table explains the stored intervention, safety warnings and efficacy limits. Nausea reductions are not turned into a substitute for antiemetics or diagnosis, or into new use or administration instructions.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Actual guidelines and clinical decisions are separate in scope. This table provides no new steps, frequency, doses or cause-specific treatment recommendations.
Required materials and conditions: The boundary between stored evidence and use, administration or clinical guidance
Materials to obtain first: Actual guidelines and clinical decisions are separate in scope. This table provides no new steps, frequency, doses or cause-specific treatment recommendations.
Further research: Material needed: Actual guidelines and clinical decisions are separate in scope. This table provides no new steps, frequency, doses or cause-specific treatment recommendations. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on The boundary between stored evidence and use, administration or clinical guidance must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on The boundary between stored evidence and use, administration or clinical guidance is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

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N15 · Which adults in the emergency department were studied?

Current findings: The stored scope is acute nausea in adults in the emergency department. Its population account repeats Beadle's 84 recruited and 80 completed and the group numbers, but does not define all causes or eligibility criteria.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. The findings are not extended to children, pregnancy or other settings.
Required materials and conditions: Eligibility, causes and baseline severity of acute nausea
Materials to obtain first: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. The findings are not extended to children, pregnancy or other settings.
Further research: Material needed: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. The findings are not extended to children, pregnancy or other settings. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Eligibility, causes and baseline severity of acute nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Eligibility, causes and baseline severity of acute nausea is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N16 · Which formulation and route were studied?

Current findings: The stored intervention is brief inhalation using a 70% isopropyl-alcohol pad. The 70% is a concentration, not an inhaled amount, frequency or exposure dose. The record distinguishes ingestion and broad skin application.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Product, manufacturing, pad capacity, exposure criteria and consistency across groups are needed. No new use or administration instructions are provided.
Required materials and conditions: The intervention boundary and exposure information for the original 70% pad
Materials to obtain first: Product, manufacturing, pad capacity, exposure criteria and consistency across groups are needed. No new use or administration instructions are provided.
Further research: Material needed: Product, manufacturing, pad capacity, exposure criteria and consistency across groups are needed. No new use or administration instructions are provided. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on The intervention boundary and exposure information for the original 70% pad must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on The intervention boundary and exposure information for the original 70% pad is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N17 · Are saline-odor controls and drug co-treatment comparisons the same?

Current findings: Beadle compares alcohol with saline odor. The Korean account of NCT02760069 describes 120 people, 3 arms and ondansetron co-treatment. The comparators and results of the two comparisons are not used as the same effect.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original group interventions, concomitant antiemetics, allocation, rescue criteria, the effect of interest and direct between-group results are needed.
Required materials and conditions: Distinguishing comparators, co-treatment, rescue drugs and the effect of interest
Materials to obtain first: Original group interventions, concomitant antiemetics, allocation, rescue criteria, the effect of interest and direct between-group results are needed.
Further research: Material needed: Original group interventions, concomitant antiemetics, allocation, rescue criteria, the effect of interest and direct between-group results are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Distinguishing comparators, co-treatment, rescue drugs and the effect of interest must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Distinguishing comparators, co-treatment, rescue drugs and the effect of interest is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N18 · Are recruitment, completion, ITT and outcome denominators the same?

Current findings: Beadle reports 84 recruited and 80 completed, with 37 alcohol and 43 saline; the Korean account describes 80 analysed. Candemir reports 118 ITT and 115 completed. The separate 120-person 3-arm trial and the review's 195 people are different contexts.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Recruitment, allocation, completion, time-specific assessment and analysis flow, group missingness, withdrawals and ITT definitions are needed. Differences, participants and reports are not newly calculated or summed.
Required materials and conditions: Trial-specific allocation, completion and analysis denominators
Materials to obtain first: Recruitment, allocation, completion, time-specific assessment and analysis flow, group missingness, withdrawals and ITT definitions are needed. Differences, participants and reports are not newly calculated or summed.
Further research: Material needed: Recruitment, allocation, completion, time-specific assessment and analysis flow, group missingness, withdrawals and ITT definitions are needed. Differences, participants and reports are not newly calculated or summed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Trial-specific allocation, completion and analysis denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Trial-specific allocation, completion and analysis denominators is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N19 · Could odor have made blinding incomplete?

Current findings: The stored counterview and citation record incomplete blinding due to odor. The label randomized trial alone does not establish adequate blinding of subjective nausea assessments and assessors.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Allocation, concealment, who was blinded, blinding-success assessment, NRS collectors and procedures, withdrawals and revealing cues are needed. No new formal RoB2 assessment is made.
Required materials and conditions: Allocation, concealment, subjective measurement and expectancy
Materials to obtain first: Allocation, concealment, who was blinded, blinding-success assessment, NRS collectors and procedures, withdrawals and revealing cues are needed. No new formal RoB2 assessment is made.
Further research: Material needed: Allocation, concealment, who was blinded, blinding-success assessment, NRS collectors and procedures, withdrawals and revealing cues are needed. No new formal RoB2 assessment is made. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Allocation, concealment, subjective measurement and expectancy must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Allocation, concealment, subjective measurement and expectancy is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N20 · Have trial registrations and review registrations actually been read?

Current findings: NCT02092441 appears in the stored evidence and citation, and NCT02760069 in the Korean account. Candemir's registration is unverified. CRD42022299815 identifies April's review registration, not a clinical trial registration. No external registration or plan was read in this work.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original registrations, amendments, protocols, SAPs and prospective endpoints and denominators are needed separately for trials and reviews. An identifier alone is not verification of prospective specification.
Required materials and conditions: Distinguishing trial and review registration from prospective plans
Materials to obtain first: Original registrations, amendments, protocols, SAPs and prospective endpoints and denominators are needed separately for trials and reviews. An identifier alone is not verification of prospective specification.
Further research: Material needed: Original registrations, amendments, protocols, SAPs and prospective endpoints and denominators are needed separately for trials and reviews. An identifier alone is not verification of prospective specification. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Distinguishing trial and review registration from prospective plans must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Distinguishing trial and review registration from prospective plans is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N21 · Are company funding, product supply, affiliations and analysis roles separated?

Current findings: The stored material describes Beadle as a military institutional study without manufacturer sponsorship, Candemir as reporting no conflict of interest with detailed funding unverified, and April as academic research without manufacturer involvement. Detailed funding for NCT02760069 is absent from the Korean account.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Separate documents on financial support, product support, company affiliations and design, analysis or publication roles are needed. Conflict-of-interest or sponsorship wording alone does not establish absence across every category.
Required materials and conditions: Different aspects of company involvement by report
Materials to obtain first: Separate documents on financial support, product support, company affiliations and design, analysis or publication roles are needed. Conflict-of-interest or sponsorship wording alone does not establish absence across every category.
Further research: Material needed: Separate documents on financial support, product support, company affiliations and design, analysis or publication roles are needed. Conflict-of-interest or sponsorship wording alone does not establish absence across every category. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Different aspects of company involvement by report must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Different aspects of company involvement by report is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N22 · Are reports and trials included in reviews counted twice?

Current findings: The two subclaims share parent 3012's Beadle, Candemir and April records and the separate Korean 3-arm summary. April is a review including original trials, and the Korean account of 120 people is not a separate evidence or citation entry.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Included-trial, time-specific analysis-population, report and cohort identification tables are needed. Reports, sheets and original numbers are not summed as unique trials, participants or independent replications.
Required materials and conditions: Reports, original trials, participants and shared relationships
Materials to obtain first: Included-trial, time-specific analysis-population, report and cohort identification tables are needed. Reports, sheets and original numbers are not summed as unique trials, participants or independent replications.
Further research: Material needed: Included-trial, time-specific analysis-population, report and cohort identification tables are needed. Reports, sheets and original numbers are not summed as unique trials, participants or independent replications. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Reports, original trials, participants and shared relationships must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Reports, original trials, participants and shared relationships is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N23 · Has the stored description of independent replication been verified?

Current findings: The stored assessment labels Candemir an independent replication while also describing its funding, registration and prospective specification as unclear. This historical wording is not converted into current verification of independence.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original registration, prospective plans, institutions, recruitment, support and overlapping-report relationships are needed. The number of unique independent trials is unverified.
Required materials and conditions: Candemir's supportive result versus unverified funding and prospective specification
Materials to obtain first: Original registration, prospective plans, institutions, recruitment, support and overlapping-report relationships are needed. The number of unique independent trials is unverified.
Further research: Material needed: Original registration, prospective plans, institutions, recruitment, support and overlapping-report relationships are needed. The number of unique independent trials is unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Candemir's supportive result versus unverified funding and prospective specification must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Candemir's supportive result versus unverified funding and prospective specification is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03

N24 · Are the different Korean and English contexts distinguished?

Current findings: The stored Korean explanation describes NCT02760069's 30-minute within-group VAS results. The English explanation contains the 10-minute meta-analysis of two placebo-controlled trials and 195 people. They are not substituted as translations of the same report, time or between-group effect.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original trial and review tables, denominators, times and effects of interest need comparison. Both stored language accounts are retained without new external comparison or correction.
Required materials and conditions: The Korean 30-minute 3-arm account versus the English pooled result
Materials to obtain first: Original trial and review tables, denominators, times and effects of interest need comparison. Both stored language accounts are retained without new external comparison or correction.
Further research: Material needed: Original trial and review tables, denominators, times and effects of interest need comparison. Both stored language accounts are retained without new external comparison or correction. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on The Korean 30-minute 3-arm account versus the English pooled result must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on The Korean 30-minute 3-arm account versus the English pooled result is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N25 · Does reading a stored summary differ from reading external materials?

Current findings: The complete stored assessment was read. Citation wording such as checked and cross-check incorporated describes historical work. External abstracts, full texts, registrations, protocols and SAPs remain unread in this work.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Access and reading status need separate records when actual materials are obtained and reviewed. A URL alone does not establish full-text reading, accessibility or completed review.
Required materials and conditions: Reading scope for summaries, abstracts, full texts, registrations and plans
Materials to obtain first: Access and reading status need separate records when actual materials are obtained and reviewed. A URL alone does not establish full-text reading, accessibility or completed review.
Further research: Material needed: Access and reading status need separate records when actual materials are obtained and reviewed. A URL alone does not establish full-text reading, accessibility or completed review. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Reading scope for summaries, abstracts, full texts, registrations and plans must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Reading scope for summaries, abstracts, full texts, registrations and plans is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N26 · Are adverse-event collection, denominators and exposure known?

Current findings: The stored safety account contains existing warnings about harms and emergency symptoms. April lists adverse events as an endpoint, but the summary lacks group event counts, collection methods, denominators and exposure. No new use or administration instructions are provided.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Collection methods, events, affected people, severity, times, exposure, group denominators, discontinuation, rescue and causal-assessment data are needed. Missing numbers do not mean safe or harmless.
Required materials and conditions: Harms such as dizziness, headache, cough and respiratory irritation
Materials to obtain first: Collection methods, events, affected people, severity, times, exposure, group denominators, discontinuation, rescue and causal-assessment data are needed. Missing numbers do not mean safe or harmless.
Further research: Material needed: Collection methods, events, affected people, severity, times, exposure, group denominators, discontinuation, rescue and causal-assessment data are needed. Missing numbers do not mean safe or harmless. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Harms such as dizziness, headache, cough and respiratory irritation must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on Harms such as dizziness, headache, cough and respiratory irritation is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N27 · Can a brief trial establish repeated exposure, long-term use or vulnerable-group safety?

Current findings: The representative endpoint is 10 minutes, with a separate 30-minute Korean context. These are not extended to verification of safety for long-term or repeated exposure, pregnancy or respiratory vulnerability. The stored safety account is distinguished as existing warnings.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Long-term or repeated exposure, vulnerable-group eligibility, group harm follow-up, denominators and actual exposure data are needed. No new research or searches were performed.
Required materials and conditions: Brief observation versus long-term, rare harms and vulnerable populations
Materials to obtain first: Long-term or repeated exposure, vulnerable-group eligibility, group harm follow-up, denominators and actual exposure data are needed. No new research or searches were performed.
Further research: Material needed: Long-term or repeated exposure, vulnerable-group eligibility, group harm follow-up, denominators and actual exposure data are needed. No new research or searches were performed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on The boundary between brief observation and longer-term, rare harms or vulnerable groups must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on The boundary between brief observation and longer-term, rare harms or vulnerable groups is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N28 · How are subclaim grades C and D distinguished from parent C54?

Current findings: The acute-nausea subclaim is C and the actual-vomiting or underlying-cause-treatment subclaim is D. Individual scores, statuses and axes are absent; parent C54, caution and B/P/R1/I2/E+/B2/CX belong to the overall nausea assessment.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: The boundary between subclaim and parent application must be distinguished. D is not replaced with C54, and no new subclaim score, harm grade or independence certification is created.
Required materials and conditions: The selected grade versus the parent score, caution status and axes
Materials to obtain first: The boundary between subclaim and parent application must be distinguished. D is not replaced with C54, and no new subclaim score, harm grade or independence certification is created.
Further research: Material needed: The boundary between subclaim and parent application must be distinguished. D is not replaced with C54, and no new subclaim score, harm grade or independence certification is created. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on The selected grade versus the parent score, caution status and axes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on The selected grade versus the parent score, caution status and axes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N29 · Did the change from draft B to final C happen in this work?

Current findings: The stored decision history records draft B, final C, score 54 and cross-check incorporation. This is a historical decision, not a new reassessment from B to C in this work.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Any assessment change needs a separate record preserving the preceding text, event, version and reasons. This table retains stored values.
Required materials and conditions: The stored assessment's decision history versus the current record
Materials to obtain first: Any assessment change needs a separate record preserving the preceding text, event, version and reasons. This table retains stored values.
Further research: Material needed: Any assessment change needs a separate record preserving the preceding text, event, version and reasons. This table retains stored values. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on The stored assessment's decision history versus the current record must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on The stored assessment's decision history versus the current record is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N30 · Are the evidence date, production time and corrections distinguished?

Current findings: The original evidence date is 2026-09-07. Corrections are stored as an empty list and deliberation as an empty string. The production time is not turned into a new evidence-verification date, and no nonexistent correction is invented.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Evidence additions, condition revisions, observation applications and assessment changes must be distinguished, preserving the preceding text and reasons for change.
Required materials and conditions: The original evidence date and empty correction or deliberation records
Materials to obtain first: Evidence additions, condition revisions, observation applications and assessment changes must be distinguished, preserving the preceding text and reasons for change.
Further research: Material needed: Evidence additions, condition revisions, observation applications and assessment changes must be distinguished, preserving the preceding text and reasons for change. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on The original evidence date and empty correction or deliberation records must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.
Why this condition is needed: Material on The original evidence date and empty correction or deliberation records is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04