{ "schema_version": "chamgap-public-criteria-1.0", "title": "Isopropyl-alcohol pad × Actual vomiting and treatment of the underlying cause—separate from short-term nausea", "language": "en", "translation_date": "2026-10-20", "criteria_version": "1.0", "criteria_date": "2026-10-06", "condition_origin": "Chamgap's own application conditions", "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.", "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.", "Review incomplete": "Review of existing content remains incomplete.", "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.", "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.", "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.", "Not applicable": "Used only with an application exception and reason based on the question scope.", "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.", "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade." }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "Which vomiting or underlying-cause claim is assessed?", "needed": "Separate assessment of actual vomiting and treatment of the underlying disease", "role": "Required", "role_reason": "Material on Separate assessment of actual vomiting and treatment of the underlying disease is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Separate assessment of actual vomiting and treatment of the underlying disease must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Original data directly comparing vomiting events and cause-specific treatment or clinical outcomes are needed. This records needed materials; no new research was executed." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "Are nausea scores, actual vomiting and treatment of the cause the same outcome?", "needed": "Distinguishing symptom scores, vomiting events and underlying-disease outcomes", "role": "Required", "role_reason": "Material on Distinguishing symptom scores, vomiting events and underlying-disease outcomes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing symptom scores, vomiting events and underlying-disease outcomes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Definitions, collection methods, times, denominators and direct between-group estimates and CIs are needed for each outcome. This records needed materials; no new research was executed." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "Has the ancillary trial that assessed vomiting been identified?", "needed": "Identity and direct relevance of the original vomiting trial", "role": "Required", "role_reason": "Material on Identity and direct relevance of the original vomiting trial is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Identity and direct relevance of the original vomiting trial must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: The trial authors, registration details, methods, original vomiting results and the review extraction table are needed. This records needed materials; no new research was executed." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "Does a null vomiting result mean effect 0 or equivalence?", "needed": "Distinguishing a limited null result from precision", "role": "Required", "role_reason": "Material on Distinguishing a limited null result from precision is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing a limited null result from precision must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Vomiting definitions, events, affected people, group denominators, estimates, CIs, tests and equivalence margins are needed. This records needed materials; no new research was executed." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "Can vomiting episodes, affected people and observation time be distinguished?", "needed": "Events, people, observation windows and risk denominators", "role": "Required", "role_reason": "Material on Events, people, observation windows and risk denominators is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Events, people, observation windows and risk denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Repeated episodes, affected people, group denominators, observation windows, post-rescue events, missingness and early-departure definitions are needed. This records needed materials; no new research was executed." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "Are Beadle's results direct evidence for treating actual vomiting?", "needed": "Distinguishing nausea NRS, satisfaction and rescue medication from vomiting", "role": "Required", "role_reason": "Material on Distinguishing nausea NRS, satisfaction and rescue medication from vomiting is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing nausea NRS, satisfaction and rescue medication from vomiting must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: The full text and endpoint-specific tables are needed to establish whether vomiting or underlying-disease endpoints were included. Outcomes omitted from a summary are not declared unreported or absent. This records needed materials; no new research was executed." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "Does Candemir's lower rescue-treatment use mean less vomiting?", "needed": "Distinguishing rescue criteria, nausea scores and vomiting events", "role": "Required", "role_reason": "Material on Distinguishing rescue criteria, nausea scores and vomiting events is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing rescue criteria, nausea scores and vomiting events must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Rescue criteria, drug types, times, denominators, original effects, CIs and vomiting-outcome collection data are needed. This records needed materials; no new research was executed." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "Do different rescue-medication results show treatment of the cause?", "needed": "Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause", "role": "Required", "role_reason": "Material on Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Rescue criteria and drugs, concurrent care, cause-specific treatment, diagnosis, fluids, admission outcomes and analysis denominators are needed. This records needed materials; no new research was executed." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "Is a review's endpoint list the same as its actual vomiting results?", "needed": "April's vomiting, rescue and adverse-event list versus quantitative results", "role": "Required", "role_reason": "Material on April's vomiting, rescue and adverse-event list versus quantitative results is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on April's vomiting, rescue and adverse-event list versus quantitative results must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Endpoint-specific included trials, extraction tables, times, events, affected people, denominators, effects, CIs and certainty data are needed. This records needed materials; no new research was executed." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "Do the 30-minute 3-arm VAS results show effects on vomiting or its cause?", "needed": "Within-group nausea change and concomitant medication in NCT02760069", "role": "Required", "role_reason": "Material on Within-group nausea change and concomitant medication in NCT02760069 is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Within-group nausea change and concomitant medication in NCT02760069 must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: The full text, vomiting and clinical endpoints, co-treatment, rescue, denominators and direct between-group effects and CIs are needed. Within-group values are not used to create between-group CIs or NRS or vomiting values. This records needed materials; no new research was executed." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Are direct results for diagnosis or treatment of the underlying disease available?", "needed": "Cause-specific diagnosis, treatment response and important clinical outcomes", "role": "Required", "role_reason": "Material on Cause-specific diagnosis, treatment response and important clinical outcomes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Cause-specific diagnosis, treatment response and important clinical outcomes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Direct comparisons of cause-specific eligibility, diagnosis, treatment, recovery, deterioration and important clinical outcomes are needed. Unverified direct data are not expanded into a claim that all research or effects are absent. This records needed materials; no new research was executed." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "Do satisfaction or symptom improvements mean less need for fluids or care?", "needed": "Distinguishing satisfaction, care, fluids and clinical course", "role": "Required", "role_reason": "Material on Distinguishing satisfaction, care, fluids and clinical course is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing satisfaction, care, fluids and clinical course must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Definitions of care, fluids, admission and discharge outcomes, decision criteria, concurrent treatment, group denominators, effects and CIs are needed. This records needed materials; no new research was executed." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "How do null vomiting results differ from unproven sustained effects?", "needed": "Distinguishing limited vomiting assessment from recurrence and longer-term course", "role": "Required", "role_reason": "Material on Distinguishing limited vomiting assessment from recurrence and longer-term course is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing limited vomiting assessment from recurrence and longer-term course must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Direct data assessing vomiting windows, recurrence, return visits, persistence, treatment of the cause and recovery with longer follow-up and denominators are needed. This records needed materials; no new research was executed." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "Does this checklist provide new use or administration instructions?", "needed": "The boundary between stored evidence and use, administration or clinical guidance", "role": "Supplementary", "role_reason": "Material on The boundary between stored evidence and use, administration or clinical guidance is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on The boundary between stored evidence and use, administration or clinical guidance must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Actual guidelines and clinical decisions are separate in scope. This table provides no new steps, frequency, doses or cause-specific treatment recommendations. This records needed materials; no new research was executed." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Which adults in the emergency department were studied?", "needed": "Eligibility, causes and baseline severity of acute nausea", "role": "Required", "role_reason": "Material on Eligibility, causes and baseline severity of acute nausea is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Eligibility, causes and baseline severity of acute nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. The findings are not extended to children, pregnancy or other settings. This records needed materials; no new research was executed." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Which formulation and route were studied?", "needed": "The intervention boundary and exposure information for the original 70% pad", "role": "Required", "role_reason": "Material on The intervention boundary and exposure information for the original 70% pad is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on The intervention boundary and exposure information for the original 70% pad must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Product, manufacturing, pad capacity, exposure criteria and consistency across groups are needed. No new use or administration instructions are provided. This records needed materials; no new research was executed." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Are saline-odor controls and drug co-treatment comparisons the same?", "needed": "Distinguishing comparators, co-treatment, rescue drugs and the effect of interest", "role": "Required", "role_reason": "Material on Distinguishing comparators, co-treatment, rescue drugs and the effect of interest is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing comparators, co-treatment, rescue drugs and the effect of interest must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Original group interventions, concomitant antiemetics, allocation, rescue criteria, the effect of interest and direct between-group results are needed. This records needed materials; no new research was executed." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "Are recruitment, completion, ITT and outcome denominators the same?", "needed": "Trial-specific allocation, completion and analysis denominators", "role": "Required", "role_reason": "Material on Trial-specific allocation, completion and analysis denominators is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Trial-specific allocation, completion and analysis denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Recruitment, allocation, completion, time-specific assessment and analysis flow, group missingness, withdrawals and ITT definitions are needed. Differences, participants and reports are not newly calculated or summed. This records needed materials; no new research was executed." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Could odor have made blinding incomplete?", "needed": "Allocation, concealment, subjective measurement and expectancy", "role": "Required", "role_reason": "Material on Allocation, concealment, subjective measurement and expectancy is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Allocation, concealment, subjective measurement and expectancy must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Allocation, concealment, who was blinded, blinding-success assessment, NRS collectors and procedures, withdrawals and revealing cues are needed. No new formal RoB2 assessment is made. This records needed materials; no new research was executed." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "Have trial registrations and review registrations actually been read?", "needed": "Distinguishing trial and review registration from prospective plans", "role": "Required", "role_reason": "Material on Distinguishing trial and review registration from prospective plans is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing trial and review registration from prospective plans must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Original registrations, amendments, protocols, SAPs and prospective endpoints and denominators are needed separately for trials and reviews. An identifier alone is not verification of prospective specification. This records needed materials; no new research was executed." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "Are company funding, product supply, affiliations and analysis roles separated?", "needed": "Different aspects of company involvement by report", "role": "Required", "role_reason": "Material on Different aspects of company involvement by report is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Different aspects of company involvement by report must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Separate documents on financial support, product support, company affiliations and design, analysis or publication roles are needed. Conflict-of-interest or sponsorship wording alone does not establish absence across every category. This records needed materials; no new research was executed." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "Are reports and trials included in reviews counted twice?", "needed": "Reports, original trials, participants and shared relationships", "role": "Required", "role_reason": "Material on Reports, original trials, participants and shared relationships is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Reports, original trials, participants and shared relationships must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Included-trial, time-specific analysis-population, report and cohort identification tables are needed. Reports, sheets and original numbers are not summed as unique trials, participants or independent replications. This records needed materials; no new research was executed." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "Has the stored description of independent replication been verified?", "needed": "Candemir's supportive result versus unverified funding and prospective specification", "role": "Required", "role_reason": "Material on Candemir's supportive result versus unverified funding and prospective specification is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Candemir's supportive result versus unverified funding and prospective specification must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Original registration, prospective plans, institutions, recruitment, support and overlapping-report relationships are needed. The number of unique independent trials is unverified. This records needed materials; no new research was executed." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Are the different Korean and English contexts distinguished?", "needed": "The Korean 30-minute 3-arm account versus the English pooled result", "role": "Required", "role_reason": "Material on The Korean 30-minute 3-arm account versus the English pooled result is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on The Korean 30-minute 3-arm account versus the English pooled result must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Original trial and review tables, denominators, times and effects of interest need comparison. Both stored language accounts are retained without new external comparison or correction. This records needed materials; no new research was executed." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "Does reading a stored summary differ from reading external materials?", "needed": "Reading scope for summaries, abstracts, full texts, registrations and plans", "role": "Required", "role_reason": "Material on Reading scope for summaries, abstracts, full texts, registrations and plans is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Reading scope for summaries, abstracts, full texts, registrations and plans must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Access and reading status need separate records when actual materials are obtained and reviewed. A URL alone does not establish full-text reading, accessibility or completed review. This records needed materials; no new research was executed." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "Are adverse-event collection, denominators and exposure known?", "needed": "Harms such as dizziness, headache, cough and respiratory irritation", "role": "Supplementary", "role_reason": "Material on Harms such as dizziness, headache, cough and respiratory irritation is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Harms such as dizziness, headache, cough and respiratory irritation must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Collection methods, events, affected people, severity, times, exposure, group denominators, discontinuation, rescue and causal-assessment data are needed. Missing numbers do not mean safe or harmless. This records needed materials; no new research was executed." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "Can a brief trial establish repeated exposure, long-term use or vulnerable-group safety?", "needed": "Brief observation versus long-term, rare harms and vulnerable populations", "role": "Supplementary", "role_reason": "Material on The boundary between brief observation and longer-term, rare harms or vulnerable groups is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on The boundary between brief observation and longer-term, rare harms or vulnerable groups must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Long-term or repeated exposure, vulnerable-group eligibility, group harm follow-up, denominators and actual exposure data are needed. No new research or searches were performed. This records needed materials; no new research was executed." }, { "item_id": "N28", "question_type": "Evidence condition", "question": "How are subclaim grades C and D distinguished from parent C54?", "needed": "The selected grade versus the parent score, caution status and axes", "role": "Required", "role_reason": "Material on The selected grade versus the parent score, caution status and axes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on The selected grade versus the parent score, caution status and axes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: The boundary between subclaim and parent application must be distinguished. D is not replaced with C54, and no new subclaim score, harm grade or independence certification is created. This records needed materials; no new research was executed." }, { "item_id": "N29", "question_type": "Evidence condition", "question": "Did the change from draft B to final C happen in this work?", "needed": "The stored assessment's decision history versus the current record", "role": "Required", "role_reason": "Material on The stored assessment's decision history versus the current record is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on The stored assessment's decision history versus the current record must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Any assessment change needs a separate record preserving the preceding text, event, version and reasons. This table retains stored values. This records needed materials; no new research was executed." }, { "item_id": "N30", "question_type": "Evidence condition", "question": "Are the evidence date, production time and corrections distinguished?", "needed": "The original evidence date and empty correction or deliberation records", "role": "Required", "role_reason": "Material on The original evidence date and empty correction or deliberation records is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on The original evidence date and empty correction or deliberation records must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Evidence additions, condition revisions, observation applications and assessment changes must be distinguished, preserving the preceding text and reasons for change. This records needed materials; no new research was executed." } ] }