# Isopropyl-alcohol pad × Actual vomiting and treatment of the underlying cause—separate from short-term nausea Verdict 3012 · Evidence Check Stored-material review date: Not recorded Original evidence cut-off: 2026-09-07 Review-criteria version: 1.0 Public page/material preparation date: 2026-10-20 Clinical papers were not read directly; existing review summaries were checked. No new clinical-literature search was performed. Unverified does not mean that research is absent or that there is no effect. ## Assessment scope - Population: Actual vomiting and treatment of the underlying disease are asked about separately within acute-nausea research in emergency-department adults. Causes, detailed eligibility, baseline severity and valid endpoint-specific denominators remain unverified. Findings are not extended to other populations or settings. - Ingredient, formulation and route: The original intervention is brief inhalation from a 70% isopropyl-alcohol pad. The recorded route is retained and distinguished from ingestion or broad skin application. - Dose: 70% is the original concentration. Actual inhaled quantity, frequency and quantitative exposure remain unverified; concentration is not converted into a dose, and no new procedure or administration guidance is created. - Comparator: Saline-odor control is central, while the separate 3-arm comparison, ondansetron combinations and rescue medication are distinguished. - Measured outcome: The selected question concerns actual vomiting events and treatment of the underlying disease. Direct data and detailed denominators remain unverified. The 10-minute nausea NRS, satisfaction, rescue medication and separate 30-minute VAS are not treated as the same outcomes. - Duration: The actual vomiting observation window and follow-up for treatment of the cause remain unverified. The 10-minute nausea or separate 30-minute symptom data are not substituted for those observation periods. - Questions outside this scope: Extending short-term subjective nausea to reduced actual vomiting, treatment of the cause, less care or fluids, or sustained effects; Creating new between-group effects, CIs or NRS conversions from 30-minute within-group VAS; Converting limited null vomiting findings into precise effect 0 or equivalence certification; Adding original trials, reviews, shared reports and sheets as unique trials, participants or independent replications; Creating new procedures, administration or individual-care guidance from original concentration, route or safety cautions ## Checklist items ### N01 · Which vomiting or underlying-cause claim is assessed? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored assessment grades actual vomiting and treatment of the underlying disease D. It describes vomiting as sparsely assessed and null, and says the endpoint did not assess treatment of the cause. C54 belongs to the separate short-term nausea assessment. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Original data directly comparing vomiting events and cause-specific treatment or clinical outcomes are needed. - Required materials and conditions: Separate assessment of actual vomiting and treatment of the underlying disease - Materials to obtain first: Original data directly comparing vomiting events and cause-specific treatment or clinical outcomes are needed. - Further research: Material needed: Original data directly comparing vomiting events and cause-specific treatment or clinical outcomes are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Separate assessment of actual vomiting and treatment of the underlying disease must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Separate assessment of actual vomiting and treatment of the underlying disease is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N02 · Are nausea scores, actual vomiting and treatment of the cause the same outcome? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The 10-minute nausea NRS measures a perceived symptom. Actual vomiting events and treatment of the underlying disease are separate; the stored explanation does not extend the short-term symptom signal to those outcomes. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Definitions, collection methods, times, denominators and direct between-group estimates and CIs are needed for each outcome. - Required materials and conditions: Distinguishing symptom scores, vomiting events and underlying-disease outcomes - Materials to obtain first: Definitions, collection methods, times, denominators and direct between-group estimates and CIs are needed for each outcome. - Further research: Material needed: Definitions, collection methods, times, denominators and direct between-group estimates and CIs are needed for each outcome. This records needed materials; no new research was executed. - Conditions for verification: Original material on Distinguishing symptom scores, vomiting events and underlying-disease outcomes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Distinguishing symptom scores, vomiting events and underlying-disease outcomes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N03 · Has the ancillary trial that assessed vomiting been identified? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored explanation says vomiting was assessed in only one ancillary trial and was null. The trial identity, vomiting counts, denominators, times and CIs are not linked, so it is not assigned to Beadle or Candemir. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: The trial authors, registration details, methods, original vomiting results and the review extraction table are needed. - Required materials and conditions: Identity and direct relevance of the original vomiting trial - Materials to obtain first: The trial authors, registration details, methods, original vomiting results and the review extraction table are needed. - Further research: Material needed: The trial authors, registration details, methods, original vomiting results and the review extraction table are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Identity and direct relevance of the original vomiting trial must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Identity and direct relevance of the original vomiting trial is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N04 · Does a null vomiting result mean effect 0 or equivalence? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored wording concerns a null finding in a limited assessment of vomiting. Original event counts, affected people, denominators and CIs are unavailable, so it does not establish effect 0 or a precise absence of difference. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Vomiting definitions, events, affected people, group denominators, estimates, CIs, tests and equivalence margins are needed. - Required materials and conditions: Distinguishing a limited null result from precision - Materials to obtain first: Vomiting definitions, events, affected people, group denominators, estimates, CIs, tests and equivalence margins are needed. - Further research: Material needed: Vomiting definitions, events, affected people, group denominators, estimates, CIs, tests and equivalence margins are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Distinguishing a limited null result from precision must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Distinguishing a limited null result from precision is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N05 · Can vomiting episodes, affected people and observation time be distinguished? Verification status: Unverified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored material only says vomiting was sparsely assessed; it gives no numbers identifying event counts or the proportion of affected people. The 10-minute and 30-minute nausea measurements are not used as vomiting observation times. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Repeated episodes, affected people, group denominators, observation windows, post-rescue events, missingness and early-departure definitions are needed. - Required materials and conditions: Events, people, observation windows and risk denominators - Materials to obtain first: Repeated episodes, affected people, group denominators, observation windows, post-rescue events, missingness and early-departure definitions are needed. - Further research: Material needed: Repeated episodes, affected people, group denominators, observation windows, post-rescue events, missingness and early-departure definitions are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Events, people, observation windows and risk denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Events, people, observation windows and risk denominators is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N06 · Are Beadle's results direct evidence for treating actual vomiting? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: Beadle's endpoints are the 10-minute nausea NRS, satisfaction and rescue antiemetic use. Median 3 versus 6, difference 3 with CI 2–4, satisfaction +2 and null rescue use are not converted into vomiting reduction or treatment of the underlying cause. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: The full text and endpoint-specific tables are needed to establish whether vomiting or underlying-disease endpoints were included. Outcomes omitted from a summary are not declared unreported or absent. - Required materials and conditions: Distinguishing nausea NRS, satisfaction and rescue medication from vomiting - Materials to obtain first: The full text and endpoint-specific tables are needed to establish whether vomiting or underlying-disease endpoints were included. Outcomes omitted from a summary are not declared unreported or absent. - Further research: Material needed: The full text and endpoint-specific tables are needed to establish whether vomiting or underlying-disease endpoints were included. Outcomes omitted from a summary are not declared unreported or absent. This records needed materials; no new research was executed. - Conditions for verification: Original material on Distinguishing nausea NRS, satisfaction and rescue medication from vomiting must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Distinguishing nausea NRS, satisfaction and rescue medication from vomiting is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01 ### N07 · Does Candemir's lower rescue-treatment use mean less vomiting? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored results concern NRS at 2, 4 and 10 minutes, rescue treatment, an overall between-group effect from 2 minutes with P=.008, and reduced rescue treatment. Rescue treatment may depend on clinicians' decisions and criteria, so it is not treated as the same endpoint as fewer vomiting events. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Rescue criteria, drug types, times, denominators, original effects, CIs and vomiting-outcome collection data are needed. - Required materials and conditions: Distinguishing rescue criteria, nausea scores and vomiting events - Materials to obtain first: Rescue criteria, drug types, times, denominators, original effects, CIs and vomiting-outcome collection data are needed. - Further research: Material needed: Rescue criteria, drug types, times, denominators, original effects, CIs and vomiting-outcome collection data are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Distinguishing rescue criteria, nausea scores and vomiting events must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Distinguishing rescue criteria, nausea scores and vomiting events is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R02 ### N08 · Do different rescue-medication results show treatment of the cause? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: Beadle's null rescue-medication result and Candemir's reduction in rescue treatment are retained separately. Results from different trials are not combined to conclude that the need to treat the underlying disease decreased. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Rescue criteria and drugs, concurrent care, cause-specific treatment, diagnosis, fluids, admission outcomes and analysis denominators are needed. - Required materials and conditions: Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause - Materials to obtain first: Rescue criteria and drugs, concurrent care, cause-specific treatment, diagnosis, fluids, admission outcomes and analysis denominators are needed. - Further research: Material needed: Rescue criteria and drugs, concurrent care, cause-specific treatment, diagnosis, fluids, admission outcomes and analysis denominators are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02 ### N09 · Is a review's endpoint list the same as its actual vomiting results? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: April lists nausea scores, vomiting, rescue medication and adverse events among its endpoints. The stored MD -2.18/10 and CI concern nausea scores; they are not used as vomiting event counts or effects. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Endpoint-specific included trials, extraction tables, times, events, affected people, denominators, effects, CIs and certainty data are needed. - Required materials and conditions: April's vomiting, rescue and adverse-event list versus quantitative results - Materials to obtain first: Endpoint-specific included trials, extraction tables, times, events, affected people, denominators, effects, CIs and certainty data are needed. - Further research: Material needed: Endpoint-specific included trials, extraction tables, times, events, affected people, denominators, effects, CIs and certainty data are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on April's vomiting, rescue and adverse-event list versus quantitative results must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on April's vomiting, rescue and adverse-event list versus quantitative results is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R03 ### N10 · Do the 30-minute 3-arm VAS results show effects on vomiting or its cause? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: In the stored Korean account of the 120-person 3-arm trial, 30-minute VAS reductions of 30mm, 32mm and 9mm are within-group nausea changes. Ondansetron co-treatment and the different comparators are distinguished; the values are not converted into vomiting events or underlying-disease outcomes. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: The full text, vomiting and clinical endpoints, co-treatment, rescue, denominators and direct between-group effects and CIs are needed. Within-group values are not used to create between-group CIs or NRS or vomiting values. - Required materials and conditions: Within-group nausea change and concomitant medication in NCT02760069 - Materials to obtain first: The full text, vomiting and clinical endpoints, co-treatment, rescue, denominators and direct between-group effects and CIs are needed. Within-group values are not used to create between-group CIs or NRS or vomiting values. - Further research: Material needed: The full text, vomiting and clinical endpoints, co-treatment, rescue, denominators and direct between-group effects and CIs are needed. Within-group values are not used to create between-group CIs or NRS or vomiting values. This records needed materials; no new research was executed. - Conditions for verification: Original material on Within-group nausea change and concomitant medication in NCT02760069 must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Within-group nausea change and concomitant medication in NCT02760069 is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R04 ### N11 · Are direct results for diagnosis or treatment of the underlying disease available? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored explanation says there is no evidence of reduced need for emergency-department diagnosis, treatment of the cause or fluids. Original values and denominators for cause-specific diagnostic or treatment outcomes are not supplied. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Direct comparisons of cause-specific eligibility, diagnosis, treatment, recovery, deterioration and important clinical outcomes are needed. Unverified direct data are not expanded into a claim that all research or effects are absent. - Required materials and conditions: Cause-specific diagnosis, treatment response and important clinical outcomes - Materials to obtain first: Direct comparisons of cause-specific eligibility, diagnosis, treatment, recovery, deterioration and important clinical outcomes are needed. Unverified direct data are not expanded into a claim that all research or effects are absent. - Further research: Material needed: Direct comparisons of cause-specific eligibility, diagnosis, treatment, recovery, deterioration and important clinical outcomes are needed. Unverified direct data are not expanded into a claim that all research or effects are absent. This records needed materials; no new research was executed. - Conditions for verification: Original material on Cause-specific diagnosis, treatment response and important clinical outcomes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Cause-specific diagnosis, treatment response and important clinical outcomes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N12 · Do satisfaction or symptom improvements mean less need for fluids or care? Verification status: Unverified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: Satisfaction +2 and the 10-minute NRS difference are their respective symptom or satisfaction outcomes. The stored material has no direct effect estimates for reduced fluids, care, admission or treatment of the cause. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Definitions of care, fluids, admission and discharge outcomes, decision criteria, concurrent treatment, group denominators, effects and CIs are needed. - Required materials and conditions: Distinguishing satisfaction, care, fluids and clinical course - Materials to obtain first: Definitions of care, fluids, admission and discharge outcomes, decision criteria, concurrent treatment, group denominators, effects and CIs are needed. - Further research: Material needed: Definitions of care, fluids, admission and discharge outcomes, decision criteria, concurrent treatment, group denominators, effects and CIs are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Distinguishing satisfaction, care, fluids and clinical course must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Distinguishing satisfaction, care, fluids and clinical course is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N13 · How do null vomiting results differ from unproven sustained effects? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored explanation describes vomiting and sustained effects as unproven. The 10-minute and separate 30-minute symptom data do not guarantee recurrence prevention, treatment of persistent vomiting or the longer-term course of the underlying disease. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Direct data assessing vomiting windows, recurrence, return visits, persistence, treatment of the cause and recovery with longer follow-up and denominators are needed. - Required materials and conditions: Distinguishing limited vomiting assessment from recurrence and longer-term course - Materials to obtain first: Direct data assessing vomiting windows, recurrence, return visits, persistence, treatment of the cause and recovery with longer follow-up and denominators are needed. - Further research: Material needed: Direct data assessing vomiting windows, recurrence, return visits, persistence, treatment of the cause and recovery with longer follow-up and denominators are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Distinguishing limited vomiting assessment from recurrence and longer-term course must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Distinguishing limited vomiting assessment from recurrence and longer-term course is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N14 · Does this checklist provide new use or administration instructions? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: This table explains the stored intervention, safety warnings and efficacy limits. Nausea reductions are not turned into a substitute for antiemetics or diagnosis, or into new use or administration instructions. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Actual guidelines and clinical decisions are separate in scope. This table provides no new steps, frequency, doses or cause-specific treatment recommendations. - Required materials and conditions: The boundary between stored evidence and use, administration or clinical guidance - Materials to obtain first: Actual guidelines and clinical decisions are separate in scope. This table provides no new steps, frequency, doses or cause-specific treatment recommendations. - Further research: Material needed: Actual guidelines and clinical decisions are separate in scope. This table provides no new steps, frequency, doses or cause-specific treatment recommendations. This records needed materials; no new research was executed. - Conditions for verification: Original material on The boundary between stored evidence and use, administration or clinical guidance must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on The boundary between stored evidence and use, administration or clinical guidance is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N15 · Which adults in the emergency department were studied? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored scope is acute nausea in adults in the emergency department. Its population account repeats Beadle's 84 recruited and 80 completed and the group numbers, but does not define all causes or eligibility criteria. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. The findings are not extended to children, pregnancy or other settings. - Required materials and conditions: Eligibility, causes and baseline severity of acute nausea - Materials to obtain first: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. The findings are not extended to children, pregnancy or other settings. - Further research: Material needed: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. The findings are not extended to children, pregnancy or other settings. This records needed materials; no new research was executed. - Conditions for verification: Original material on Eligibility, causes and baseline severity of acute nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Eligibility, causes and baseline severity of acute nausea is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N16 · Which formulation and route were studied? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored intervention is brief inhalation using a 70% isopropyl-alcohol pad. The 70% is a concentration, not an inhaled amount, frequency or exposure dose. The record distinguishes ingestion and broad skin application. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Product, manufacturing, pad capacity, exposure criteria and consistency across groups are needed. No new use or administration instructions are provided. - Required materials and conditions: The intervention boundary and exposure information for the original 70% pad - Materials to obtain first: Product, manufacturing, pad capacity, exposure criteria and consistency across groups are needed. No new use or administration instructions are provided. - Further research: Material needed: Product, manufacturing, pad capacity, exposure criteria and consistency across groups are needed. No new use or administration instructions are provided. This records needed materials; no new research was executed. - Conditions for verification: Original material on The intervention boundary and exposure information for the original 70% pad must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on The intervention boundary and exposure information for the original 70% pad is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N17 · Are saline-odor controls and drug co-treatment comparisons the same? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: Beadle compares alcohol with saline odor. The Korean account of NCT02760069 describes 120 people, 3 arms and ondansetron co-treatment. The comparators and results of the two comparisons are not used as the same effect. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Original group interventions, concomitant antiemetics, allocation, rescue criteria, the effect of interest and direct between-group results are needed. - Required materials and conditions: Distinguishing comparators, co-treatment, rescue drugs and the effect of interest - Materials to obtain first: Original group interventions, concomitant antiemetics, allocation, rescue criteria, the effect of interest and direct between-group results are needed. - Further research: Material needed: Original group interventions, concomitant antiemetics, allocation, rescue criteria, the effect of interest and direct between-group results are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Distinguishing comparators, co-treatment, rescue drugs and the effect of interest must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Distinguishing comparators, co-treatment, rescue drugs and the effect of interest is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N18 · Are recruitment, completion, ITT and outcome denominators the same? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: Beadle reports 84 recruited and 80 completed, with 37 alcohol and 43 saline; the Korean account describes 80 analysed. Candemir reports 118 ITT and 115 completed. The separate 120-person 3-arm trial and the review's 195 people are different contexts. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Recruitment, allocation, completion, time-specific assessment and analysis flow, group missingness, withdrawals and ITT definitions are needed. Differences, participants and reports are not newly calculated or summed. - Required materials and conditions: Trial-specific allocation, completion and analysis denominators - Materials to obtain first: Recruitment, allocation, completion, time-specific assessment and analysis flow, group missingness, withdrawals and ITT definitions are needed. Differences, participants and reports are not newly calculated or summed. - Further research: Material needed: Recruitment, allocation, completion, time-specific assessment and analysis flow, group missingness, withdrawals and ITT definitions are needed. Differences, participants and reports are not newly calculated or summed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Trial-specific allocation, completion and analysis denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Trial-specific allocation, completion and analysis denominators is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N19 · Could odor have made blinding incomplete? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored counterview and citation record incomplete blinding due to odor. The label randomized trial alone does not establish adequate blinding of subjective nausea assessments and assessors. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Allocation, concealment, who was blinded, blinding-success assessment, NRS collectors and procedures, withdrawals and revealing cues are needed. No new formal RoB2 assessment is made. - Required materials and conditions: Allocation, concealment, subjective measurement and expectancy - Materials to obtain first: Allocation, concealment, who was blinded, blinding-success assessment, NRS collectors and procedures, withdrawals and revealing cues are needed. No new formal RoB2 assessment is made. - Further research: Material needed: Allocation, concealment, who was blinded, blinding-success assessment, NRS collectors and procedures, withdrawals and revealing cues are needed. No new formal RoB2 assessment is made. This records needed materials; no new research was executed. - Conditions for verification: Original material on Allocation, concealment, subjective measurement and expectancy must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Allocation, concealment, subjective measurement and expectancy is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N20 · Have trial registrations and review registrations actually been read? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: NCT02092441 appears in the stored evidence and citation, and NCT02760069 in the Korean account. Candemir's registration is unverified. CRD42022299815 identifies April's review registration, not a clinical trial registration. No external registration or plan was read in this work. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Original registrations, amendments, protocols, SAPs and prospective endpoints and denominators are needed separately for trials and reviews. An identifier alone is not verification of prospective specification. - Required materials and conditions: Distinguishing trial and review registration from prospective plans - Materials to obtain first: Original registrations, amendments, protocols, SAPs and prospective endpoints and denominators are needed separately for trials and reviews. An identifier alone is not verification of prospective specification. - Further research: Material needed: Original registrations, amendments, protocols, SAPs and prospective endpoints and denominators are needed separately for trials and reviews. An identifier alone is not verification of prospective specification. This records needed materials; no new research was executed. - Conditions for verification: Original material on Distinguishing trial and review registration from prospective plans must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Distinguishing trial and review registration from prospective plans is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N21 · Are company funding, product supply, affiliations and analysis roles separated? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored material describes Beadle as a military institutional study without manufacturer sponsorship, Candemir as reporting no conflict of interest with detailed funding unverified, and April as academic research without manufacturer involvement. Detailed funding for NCT02760069 is absent from the Korean account. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Separate documents on financial support, product support, company affiliations and design, analysis or publication roles are needed. Conflict-of-interest or sponsorship wording alone does not establish absence across every category. - Required materials and conditions: Different aspects of company involvement by report - Materials to obtain first: Separate documents on financial support, product support, company affiliations and design, analysis or publication roles are needed. Conflict-of-interest or sponsorship wording alone does not establish absence across every category. - Further research: Material needed: Separate documents on financial support, product support, company affiliations and design, analysis or publication roles are needed. Conflict-of-interest or sponsorship wording alone does not establish absence across every category. This records needed materials; no new research was executed. - Conditions for verification: Original material on Different aspects of company involvement by report must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Different aspects of company involvement by report is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N22 · Are reports and trials included in reviews counted twice? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The two subclaims share parent 3012's Beadle, Candemir and April records and the separate Korean 3-arm summary. April is a review including original trials, and the Korean account of 120 people is not a separate evidence or citation entry. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Included-trial, time-specific analysis-population, report and cohort identification tables are needed. Reports, sheets and original numbers are not summed as unique trials, participants or independent replications. - Required materials and conditions: Reports, original trials, participants and shared relationships - Materials to obtain first: Included-trial, time-specific analysis-population, report and cohort identification tables are needed. Reports, sheets and original numbers are not summed as unique trials, participants or independent replications. - Further research: Material needed: Included-trial, time-specific analysis-population, report and cohort identification tables are needed. Reports, sheets and original numbers are not summed as unique trials, participants or independent replications. This records needed materials; no new research was executed. - Conditions for verification: Original material on Reports, original trials, participants and shared relationships must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Reports, original trials, participants and shared relationships is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N23 · Has the stored description of independent replication been verified? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored assessment labels Candemir an independent replication while also describing its funding, registration and prospective specification as unclear. This historical wording is not converted into current verification of independence. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Original registration, prospective plans, institutions, recruitment, support and overlapping-report relationships are needed. The number of unique independent trials is unverified. - Required materials and conditions: Candemir's supportive result versus unverified funding and prospective specification - Materials to obtain first: Original registration, prospective plans, institutions, recruitment, support and overlapping-report relationships are needed. The number of unique independent trials is unverified. - Further research: Material needed: Original registration, prospective plans, institutions, recruitment, support and overlapping-report relationships are needed. The number of unique independent trials is unverified. This records needed materials; no new research was executed. - Conditions for verification: Original material on Candemir's supportive result versus unverified funding and prospective specification must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Candemir's supportive result versus unverified funding and prospective specification is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03 ### N24 · Are the different Korean and English contexts distinguished? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored Korean explanation describes NCT02760069's 30-minute within-group VAS results. The English explanation contains the 10-minute meta-analysis of two placebo-controlled trials and 195 people. They are not substituted as translations of the same report, time or between-group effect. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Original trial and review tables, denominators, times and effects of interest need comparison. Both stored language accounts are retained without new external comparison or correction. - Required materials and conditions: The Korean 30-minute 3-arm account versus the English pooled result - Materials to obtain first: Original trial and review tables, denominators, times and effects of interest need comparison. Both stored language accounts are retained without new external comparison or correction. - Further research: Material needed: Original trial and review tables, denominators, times and effects of interest need comparison. Both stored language accounts are retained without new external comparison or correction. This records needed materials; no new research was executed. - Conditions for verification: Original material on The Korean 30-minute 3-arm account versus the English pooled result must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on The Korean 30-minute 3-arm account versus the English pooled result is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N25 · Does reading a stored summary differ from reading external materials? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The complete stored assessment was read. Citation wording such as checked and cross-check incorporated describes historical work. External abstracts, full texts, registrations, protocols and SAPs remain unread in this work. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Access and reading status need separate records when actual materials are obtained and reviewed. A URL alone does not establish full-text reading, accessibility or completed review. - Required materials and conditions: Reading scope for summaries, abstracts, full texts, registrations and plans - Materials to obtain first: Access and reading status need separate records when actual materials are obtained and reviewed. A URL alone does not establish full-text reading, accessibility or completed review. - Further research: Material needed: Access and reading status need separate records when actual materials are obtained and reviewed. A URL alone does not establish full-text reading, accessibility or completed review. This records needed materials; no new research was executed. - Conditions for verification: Original material on Reading scope for summaries, abstracts, full texts, registrations and plans must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Reading scope for summaries, abstracts, full texts, registrations and plans is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N26 · Are adverse-event collection, denominators and exposure known? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored safety account contains existing warnings about harms and emergency symptoms. April lists adverse events as an endpoint, but the summary lacks group event counts, collection methods, denominators and exposure. No new use or administration instructions are provided. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Collection methods, events, affected people, severity, times, exposure, group denominators, discontinuation, rescue and causal-assessment data are needed. Missing numbers do not mean safe or harmless. - Required materials and conditions: Harms such as dizziness, headache, cough and respiratory irritation - Materials to obtain first: Collection methods, events, affected people, severity, times, exposure, group denominators, discontinuation, rescue and causal-assessment data are needed. Missing numbers do not mean safe or harmless. - Further research: Material needed: Collection methods, events, affected people, severity, times, exposure, group denominators, discontinuation, rescue and causal-assessment data are needed. Missing numbers do not mean safe or harmless. This records needed materials; no new research was executed. - Conditions for verification: Original material on Harms such as dizziness, headache, cough and respiratory irritation must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on Harms such as dizziness, headache, cough and respiratory irritation is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N27 · Can a brief trial establish repeated exposure, long-term use or vulnerable-group safety? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The representative endpoint is 10 minutes, with a separate 30-minute Korean context. These are not extended to verification of safety for long-term or repeated exposure, pregnancy or respiratory vulnerability. The stored safety account is distinguished as existing warnings. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Long-term or repeated exposure, vulnerable-group eligibility, group harm follow-up, denominators and actual exposure data are needed. No new research or searches were performed. - Required materials and conditions: Brief observation versus long-term, rare harms and vulnerable populations - Materials to obtain first: Long-term or repeated exposure, vulnerable-group eligibility, group harm follow-up, denominators and actual exposure data are needed. No new research or searches were performed. - Further research: Material needed: Long-term or repeated exposure, vulnerable-group eligibility, group harm follow-up, denominators and actual exposure data are needed. No new research or searches were performed. This records needed materials; no new research was executed. - Conditions for verification: Original material on The boundary between brief observation and longer-term, rare harms or vulnerable groups must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on The boundary between brief observation and longer-term, rare harms or vulnerable groups is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N28 · How are subclaim grades C and D distinguished from parent C54? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The acute-nausea subclaim is C and the actual-vomiting or underlying-cause-treatment subclaim is D. Individual scores, statuses and axes are absent; parent C54, caution and B/P/R1/I2/E+/B2/CX belong to the overall nausea assessment. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: The boundary between subclaim and parent application must be distinguished. D is not replaced with C54, and no new subclaim score, harm grade or independence certification is created. - Required materials and conditions: The selected grade versus the parent score, caution status and axes - Materials to obtain first: The boundary between subclaim and parent application must be distinguished. D is not replaced with C54, and no new subclaim score, harm grade or independence certification is created. - Further research: Material needed: The boundary between subclaim and parent application must be distinguished. D is not replaced with C54, and no new subclaim score, harm grade or independence certification is created. This records needed materials; no new research was executed. - Conditions for verification: Original material on The selected grade versus the parent score, caution status and axes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on The selected grade versus the parent score, caution status and axes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N29 · Did the change from draft B to final C happen in this work? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The stored decision history records draft B, final C, score 54 and cross-check incorporation. This is a historical decision, not a new reassessment from B to C in this work. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Any assessment change needs a separate record preserving the preceding text, event, version and reasons. This table retains stored values. - Required materials and conditions: The stored assessment's decision history versus the current record - Materials to obtain first: Any assessment change needs a separate record preserving the preceding text, event, version and reasons. This table retains stored values. - Further research: Material needed: Any assessment change needs a separate record preserving the preceding text, event, version and reasons. This table retains stored values. This records needed materials; no new research was executed. - Conditions for verification: Original material on The stored assessment's decision history versus the current record must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on The stored assessment's decision history versus the current record is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N30 · Are the evidence date, production time and corrections distinguished? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The original evidence date is 2026-09-07. Corrections are stored as an empty list and deliberation as an empty string. The production time is not turned into a new evidence-verification date, and no nonexistent correction is invented. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Evidence additions, condition revisions, observation applications and assessment changes must be distinguished, preserving the preceding text and reasons for change. - Required materials and conditions: The original evidence date and empty correction or deliberation records - Materials to obtain first: Evidence additions, condition revisions, observation applications and assessment changes must be distinguished, preserving the preceding text and reasons for change. - Further research: Material needed: Evidence additions, condition revisions, observation applications and assessment changes must be distinguished, preserving the preceding text and reasons for change. This records needed materials; no new research was executed. - Conditions for verification: Original material on The original evidence date and empty correction or deliberation records must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material. - Why this condition is needed: Material on The original evidence date and empty correction or deliberation records is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ## Evidence and sources ### R01 Beadle KL et al. 2016 [PubMed](https://pubmed.ncbi.nlm.nih.gov/26679977/) Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread. Findings recorded in the summary: The record states 84 recruited, 80 completed, 37 alcohol and 43 saline. Original 10-minute medians of 3 versus 6, difference 3 (95% CI 2 to 4), satisfaction +2 and null rescue use are retained. Record level: This is a stored summary of direct NRS findings. Recruitment, completion, analysis wording and endpoint-specific denominators are distinguished; historical registration and verification narratives are not promoted into current external verification. These nausea, satisfaction and rescue findings are not converted into direct results for actual vomiting or treatment of the cause. Independent replication: Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Protocol and analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | ### R02 Candemir H et al. 2021 [PubMed](https://pubmed.ncbi.nlm.nih.gov/33373914/) Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread. Findings recorded in the summary: The report records 118 in ITT, 115 completed, nausea NRS at 2, 4 and 10 minutes and rescue treatment. The overall between-group effect from 2 minutes, P=.008, and less rescue treatment are retained without copying identical effects or CIs to each time. Record level: Original independent-replication wording is retained together with unverified specific funding, registration and prespecification. No current independence certification or confirmed unique-trial total is created. Less rescue treatment is not substituted as a direct estimate of fewer vomiting events or treatment of the underlying disease. Independent replication: Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Protocol and analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | ### R03 April MD et al. 2023 [PubMed](https://pubmed.ncbi.nlm.nih.gov/37076258/) Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread. Findings recorded in the summary: The original record retains 2 saline-controlled RCTs, 195 participants, 10-minute MD -2.18/10 (95% CI -2.76 to -1.60), MCID 1.5 and moderate certainty. Record level: These are the original review's criteria and certainty narratives. Externally validated important differences, extraction from included trials and overlap remain unverified; the review is not counted as a new original trial or current official GRADE assessment. Listed vomiting, rescue and adverse-event endpoints are distinguished from quantitative nausea results; the original vomiting results table is unread. Independent replication: Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Protocol and analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | ### R04 Separate 3-arm summary in the stored Korean account Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread. Findings recorded in the summary: The 120-person, 3-arm, 30-minute within-group VAS reductions are 30mm with alcohol, 32mm with ondansetron plus alcohol and 9mm with ondansetron plus saline. This remains separate Korean context without new between-group effects, CIs or NRS conversion. Record level: This is preserved context from the parent Korean explanation. Detailed bibliography, an original-text URL, arm-specific analysis denominators and original between-group results are unlinked; no external link is newly inferred. These within-group nausea changes are distinguished from actual vomiting or treatment-of-cause outcomes. Independent replication: Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Protocol and analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | ## Review criteria and methods These are Chamgap's own application conditions, informed by the relevant sections of official methodological guidance. They do not constitute official assessment-tool certification or a new efficacy score. - M03 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03) · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13 · Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M04 [Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04) · §4.5, §4.6.1–4.6.3, MECIR C42 · Distinguish studies from reports and link them; do not omit a study solely because results are unreported. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M08 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08) · §8.1–8.2.3, Table 8.2.a · Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M15 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15) · §15.2.4, §15.3.1–15.3.3 · Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M19 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19) · §19.1.2, §19.2.1–19.2.4 · Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. ## What the statuses mean - Partly verified: Partial information from the stored summary is linked; detailed originals and content review remain incomplete. - Unverified: Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety. - Review incomplete: Review of existing content remains incomplete. - Met: This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work. - Not reported: Unreported within material actually read. Unread external material is not relabeled as unreported. - Inaccessible: This means actual access failure. External access was not attempted in this work, so this state was not assigned. - Not applicable: Used only with an application exception and reason based on the question scope. - Conflicting data: This requires actual comparison of materials; no new conflict judgment was made in this work. - Insufficient evidence for the conditions: This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade. ## Change history 2026-10-20 · Public page/materials 1.0. Public-facing views and materials were prepared from the existing 30 items. No new clinical search, verification-status change or scoring was performed.