{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3012-s1", "verdict_number": "3012", "title": "Isopropyl-alcohol pad × Actual vomiting and treatment of the underlying cause—separate from short-term nausea", "view_version": "1.0", "view_created_date": "2026-10-20", "criteria_version": "1.0", "criteria_date": "2026-10-06", "review_date": null, "legacy_evidence_date": "2026-09-07", "review_scope": { "materials_read": "Existing review summaries and stored records of methodological application", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.", "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature." }, "claim_context": { "population": "Actual vomiting and treatment of the underlying disease are asked about separately within acute-nausea research in emergency-department adults. Causes, detailed eligibility, baseline severity and valid endpoint-specific denominators remain unverified. Findings are not extended to other populations or settings.", "intervention": "The original intervention is brief inhalation from a 70% isopropyl-alcohol pad. The recorded route is retained and distinguished from ingestion or broad skin application.", "dose": "70% is the original concentration. Actual inhaled quantity, frequency and quantitative exposure remain unverified; concentration is not converted into a dose, and no new procedure or administration guidance is created.", "comparator": "Saline-odor control is central, while the separate 3-arm comparison, ondansetron combinations and rescue medication are distinguished.", "endpoint": "The selected question concerns actual vomiting events and treatment of the underlying disease. Direct data and detailed denominators remain unverified. The 10-minute nausea NRS, satisfaction, rescue medication and separate 30-minute VAS are not treated as the same outcomes.", "duration": "The actual vomiting observation window and follow-up for treatment of the cause remain unverified. The 10-minute nausea or separate 30-minute symptom data are not substituted for those observation periods.", "excluded_extensions": [ "Extending short-term subjective nausea to reduced actual vomiting, treatment of the cause, less care or fluids, or sustained effects", "Creating new between-group effects, CIs or NRS conversions from 30-minute within-group VAS", "Converting limited null vomiting findings into precise effect 0 or equivalence certification", "Adding original trials, reviews, shared reports and sheets as unique trials, participants or independent replications", "Creating new procedures, administration or individual-care guidance from original concentration, route or safety cautions" ] }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "Which vomiting or underlying-cause claim is assessed?", "needed": "Separate assessment of actual vomiting and treatment of the underlying disease", "role": "Required", "role_reason": "Material on Separate assessment of actual vomiting and treatment of the underlying disease is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Separate assessment of actual vomiting and treatment of the underlying disease must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Original data directly comparing vomiting events and cause-specific treatment or clinical outcomes are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored assessment grades actual vomiting and treatment of the underlying disease D. It describes vomiting as sparsely assessed and null, and says the endpoint did not assess treatment of the cause. C54 belongs to the separate short-term nausea assessment.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original data directly comparing vomiting events and cause-specific treatment or clinical outcomes are needed.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original data directly comparing vomiting events and cause-specific treatment or clinical outcomes are needed." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "Are nausea scores, actual vomiting and treatment of the cause the same outcome?", "needed": "Distinguishing symptom scores, vomiting events and underlying-disease outcomes", "role": "Required", "role_reason": "Material on Distinguishing symptom scores, vomiting events and underlying-disease outcomes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing symptom scores, vomiting events and underlying-disease outcomes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Definitions, collection methods, times, denominators and direct between-group estimates and CIs are needed for each outcome. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The 10-minute nausea NRS measures a perceived symptom. Actual vomiting events and treatment of the underlying disease are separate; the stored explanation does not extend the short-term symptom signal to those outcomes.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Definitions, collection methods, times, denominators and direct between-group estimates and CIs are needed for each outcome.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Definitions, collection methods, times, denominators and direct between-group estimates and CIs are needed for each outcome." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "Has the ancillary trial that assessed vomiting been identified?", "needed": "Identity and direct relevance of the original vomiting trial", "role": "Required", "role_reason": "Material on Identity and direct relevance of the original vomiting trial is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Identity and direct relevance of the original vomiting trial must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: The trial authors, registration details, methods, original vomiting results and the review extraction table are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored explanation says vomiting was assessed in only one ancillary trial and was null. The trial identity, vomiting counts, denominators, times and CIs are not linked, so it is not assigned to Beadle or Candemir.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "The trial authors, registration details, methods, original vomiting results and the review extraction table are needed.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The trial authors, registration details, methods, original vomiting results and the review extraction table are needed." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "Does a null vomiting result mean effect 0 or equivalence?", "needed": "Distinguishing a limited null result from precision", "role": "Required", "role_reason": "Material on Distinguishing a limited null result from precision is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing a limited null result from precision must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Vomiting definitions, events, affected people, group denominators, estimates, CIs, tests and equivalence margins are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored wording concerns a null finding in a limited assessment of vomiting. Original event counts, affected people, denominators and CIs are unavailable, so it does not establish effect 0 or a precise absence of difference.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Vomiting definitions, events, affected people, group denominators, estimates, CIs, tests and equivalence margins are needed.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Vomiting definitions, events, affected people, group denominators, estimates, CIs, tests and equivalence margins are needed." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "Can vomiting episodes, affected people and observation time be distinguished?", "needed": "Events, people, observation windows and risk denominators", "role": "Required", "role_reason": "Material on Events, people, observation windows and risk denominators is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Events, people, observation windows and risk denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Repeated episodes, affected people, group denominators, observation windows, post-rescue events, missingness and early-departure definitions are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored material only says vomiting was sparsely assessed; it gives no numbers identifying event counts or the proportion of affected people. The 10-minute and 30-minute nausea measurements are not used as vomiting observation times.", "condition_status": "Unverified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Repeated episodes, affected people, group denominators, observation windows, post-rescue events, missingness and early-departure definitions are needed.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Repeated episodes, affected people, group denominators, observation windows, post-rescue events, missingness and early-departure definitions are needed." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "Are Beadle's results direct evidence for treating actual vomiting?", "needed": "Distinguishing nausea NRS, satisfaction and rescue medication from vomiting", "role": "Required", "role_reason": "Material on Distinguishing nausea NRS, satisfaction and rescue medication from vomiting is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing nausea NRS, satisfaction and rescue medication from vomiting must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: The full text and endpoint-specific tables are needed to establish whether vomiting or underlying-disease endpoints were included. Outcomes omitted from a summary are not declared unreported or absent. This records needed materials; no new research was executed.", "current_reports": [ "R01" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Beadle's endpoints are the 10-minute nausea NRS, satisfaction and rescue antiemetic use. Median 3 versus 6, difference 3 with CI 2–4, satisfaction +2 and null rescue use are not converted into vomiting reduction or treatment of the underlying cause.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "The full text and endpoint-specific tables are needed to establish whether vomiting or underlying-disease endpoints were included. Outcomes omitted from a summary are not declared unreported or absent.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The full text and endpoint-specific tables are needed to establish whether vomiting or underlying-disease endpoints were included. Outcomes omitted from a summary are not declared unreported or absent." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "Does Candemir's lower rescue-treatment use mean less vomiting?", "needed": "Distinguishing rescue criteria, nausea scores and vomiting events", "role": "Required", "role_reason": "Material on Distinguishing rescue criteria, nausea scores and vomiting events is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing rescue criteria, nausea scores and vomiting events must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Rescue criteria, drug types, times, denominators, original effects, CIs and vomiting-outcome collection data are needed. This records needed materials; no new research was executed.", "current_reports": [ "R02" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored results concern NRS at 2, 4 and 10 minutes, rescue treatment, an overall between-group effect from 2 minutes with P=.008, and reduced rescue treatment. Rescue treatment may depend on clinicians' decisions and criteria, so it is not treated as the same endpoint as fewer vomiting events.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Rescue criteria, drug types, times, denominators, original effects, CIs and vomiting-outcome collection data are needed.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Rescue criteria, drug types, times, denominators, original effects, CIs and vomiting-outcome collection data are needed." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "Do different rescue-medication results show treatment of the cause?", "needed": "Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause", "role": "Required", "role_reason": "Material on Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing trial-specific rescue outcomes from diagnosis and treatment of the cause must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Rescue criteria and drugs, concurrent care, cause-specific treatment, diagnosis, fluids, admission outcomes and analysis denominators are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Beadle's null rescue-medication result and Candemir's reduction in rescue treatment are retained separately. Results from different trials are not combined to conclude that the need to treat the underlying disease decreased.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Rescue criteria and drugs, concurrent care, cause-specific treatment, diagnosis, fluids, admission outcomes and analysis denominators are needed.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Rescue criteria and drugs, concurrent care, cause-specific treatment, diagnosis, fluids, admission outcomes and analysis denominators are needed." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "Is a review's endpoint list the same as its actual vomiting results?", "needed": "April's vomiting, rescue and adverse-event list versus quantitative results", "role": "Required", "role_reason": "Material on April's vomiting, rescue and adverse-event list versus quantitative results is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on April's vomiting, rescue and adverse-event list versus quantitative results must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Endpoint-specific included trials, extraction tables, times, events, affected people, denominators, effects, CIs and certainty data are needed. This records needed materials; no new research was executed.", "current_reports": [ "R03" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "April lists nausea scores, vomiting, rescue medication and adverse events among its endpoints. The stored MD -2.18/10 and CI concern nausea scores; they are not used as vomiting event counts or effects.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Endpoint-specific included trials, extraction tables, times, events, affected people, denominators, effects, CIs and certainty data are needed.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Endpoint-specific included trials, extraction tables, times, events, affected people, denominators, effects, CIs and certainty data are needed." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "Do the 30-minute 3-arm VAS results show effects on vomiting or its cause?", "needed": "Within-group nausea change and concomitant medication in NCT02760069", "role": "Required", "role_reason": "Material on Within-group nausea change and concomitant medication in NCT02760069 is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Within-group nausea change and concomitant medication in NCT02760069 must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: The full text, vomiting and clinical endpoints, co-treatment, rescue, denominators and direct between-group effects and CIs are needed. Within-group values are not used to create between-group CIs or NRS or vomiting values. This records needed materials; no new research was executed.", "current_reports": [ "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "In the stored Korean account of the 120-person 3-arm trial, 30-minute VAS reductions of 30mm, 32mm and 9mm are within-group nausea changes. Ondansetron co-treatment and the different comparators are distinguished; the values are not converted into vomiting events or underlying-disease outcomes.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "The full text, vomiting and clinical endpoints, co-treatment, rescue, denominators and direct between-group effects and CIs are needed. Within-group values are not used to create between-group CIs or NRS or vomiting values.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The full text, vomiting and clinical endpoints, co-treatment, rescue, denominators and direct between-group effects and CIs are needed. Within-group values are not used to create between-group CIs or NRS or vomiting values." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Are direct results for diagnosis or treatment of the underlying disease available?", "needed": "Cause-specific diagnosis, treatment response and important clinical outcomes", "role": "Required", "role_reason": "Material on Cause-specific diagnosis, treatment response and important clinical outcomes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Cause-specific diagnosis, treatment response and important clinical outcomes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Direct comparisons of cause-specific eligibility, diagnosis, treatment, recovery, deterioration and important clinical outcomes are needed. Unverified direct data are not expanded into a claim that all research or effects are absent. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored explanation says there is no evidence of reduced need for emergency-department diagnosis, treatment of the cause or fluids. Original values and denominators for cause-specific diagnostic or treatment outcomes are not supplied.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Direct comparisons of cause-specific eligibility, diagnosis, treatment, recovery, deterioration and important clinical outcomes are needed. Unverified direct data are not expanded into a claim that all research or effects are absent.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct comparisons of cause-specific eligibility, diagnosis, treatment, recovery, deterioration and important clinical outcomes are needed. Unverified direct data are not expanded into a claim that all research or effects are absent." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "Do satisfaction or symptom improvements mean less need for fluids or care?", "needed": "Distinguishing satisfaction, care, fluids and clinical course", "role": "Required", "role_reason": "Material on Distinguishing satisfaction, care, fluids and clinical course is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing satisfaction, care, fluids and clinical course must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Definitions of care, fluids, admission and discharge outcomes, decision criteria, concurrent treatment, group denominators, effects and CIs are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Satisfaction +2 and the 10-minute NRS difference are their respective symptom or satisfaction outcomes. The stored material has no direct effect estimates for reduced fluids, care, admission or treatment of the cause.", "condition_status": "Unverified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Definitions of care, fluids, admission and discharge outcomes, decision criteria, concurrent treatment, group denominators, effects and CIs are needed.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Definitions of care, fluids, admission and discharge outcomes, decision criteria, concurrent treatment, group denominators, effects and CIs are needed." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "How do null vomiting results differ from unproven sustained effects?", "needed": "Distinguishing limited vomiting assessment from recurrence and longer-term course", "role": "Required", "role_reason": "Material on Distinguishing limited vomiting assessment from recurrence and longer-term course is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing limited vomiting assessment from recurrence and longer-term course must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Direct data assessing vomiting windows, recurrence, return visits, persistence, treatment of the cause and recovery with longer follow-up and denominators are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored explanation describes vomiting and sustained effects as unproven. The 10-minute and separate 30-minute symptom data do not guarantee recurrence prevention, treatment of persistent vomiting or the longer-term course of the underlying disease.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Direct data assessing vomiting windows, recurrence, return visits, persistence, treatment of the cause and recovery with longer follow-up and denominators are needed.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct data assessing vomiting windows, recurrence, return visits, persistence, treatment of the cause and recovery with longer follow-up and denominators are needed." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "Does this checklist provide new use or administration instructions?", "needed": "The boundary between stored evidence and use, administration or clinical guidance", "role": "Supplementary", "role_reason": "Material on The boundary between stored evidence and use, administration or clinical guidance is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on The boundary between stored evidence and use, administration or clinical guidance must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Actual guidelines and clinical decisions are separate in scope. This table provides no new steps, frequency, doses or cause-specific treatment recommendations. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "This table explains the stored intervention, safety warnings and efficacy limits. Nausea reductions are not turned into a substitute for antiemetics or diagnosis, or into new use or administration instructions.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Actual guidelines and clinical decisions are separate in scope. This table provides no new steps, frequency, doses or cause-specific treatment recommendations.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Actual guidelines and clinical decisions are separate in scope. This table provides no new steps, frequency, doses or cause-specific treatment recommendations." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Which adults in the emergency department were studied?", "needed": "Eligibility, causes and baseline severity of acute nausea", "role": "Required", "role_reason": "Material on Eligibility, causes and baseline severity of acute nausea is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Eligibility, causes and baseline severity of acute nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. The findings are not extended to children, pregnancy or other settings. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored scope is acute nausea in adults in the emergency department. Its population account repeats Beadle's 84 recruited and 80 completed and the group numbers, but does not define all causes or eligibility criteria.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. The findings are not extended to children, pregnancy or other settings.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. The findings are not extended to children, pregnancy or other settings." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Which formulation and route were studied?", "needed": "The intervention boundary and exposure information for the original 70% pad", "role": "Required", "role_reason": "Material on The intervention boundary and exposure information for the original 70% pad is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on The intervention boundary and exposure information for the original 70% pad must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Product, manufacturing, pad capacity, exposure criteria and consistency across groups are needed. No new use or administration instructions are provided. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored intervention is brief inhalation using a 70% isopropyl-alcohol pad. The 70% is a concentration, not an inhaled amount, frequency or exposure dose. The record distinguishes ingestion and broad skin application.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Product, manufacturing, pad capacity, exposure criteria and consistency across groups are needed. No new use or administration instructions are provided.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Product, manufacturing, pad capacity, exposure criteria and consistency across groups are needed. No new use or administration instructions are provided." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Are saline-odor controls and drug co-treatment comparisons the same?", "needed": "Distinguishing comparators, co-treatment, rescue drugs and the effect of interest", "role": "Required", "role_reason": "Material on Distinguishing comparators, co-treatment, rescue drugs and the effect of interest is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing comparators, co-treatment, rescue drugs and the effect of interest must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Original group interventions, concomitant antiemetics, allocation, rescue criteria, the effect of interest and direct between-group results are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Beadle compares alcohol with saline odor. The Korean account of NCT02760069 describes 120 people, 3 arms and ondansetron co-treatment. The comparators and results of the two comparisons are not used as the same effect.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original group interventions, concomitant antiemetics, allocation, rescue criteria, the effect of interest and direct between-group results are needed.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original group interventions, concomitant antiemetics, allocation, rescue criteria, the effect of interest and direct between-group results are needed." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "Are recruitment, completion, ITT and outcome denominators the same?", "needed": "Trial-specific allocation, completion and analysis denominators", "role": "Required", "role_reason": "Material on Trial-specific allocation, completion and analysis denominators is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Trial-specific allocation, completion and analysis denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Recruitment, allocation, completion, time-specific assessment and analysis flow, group missingness, withdrawals and ITT definitions are needed. Differences, participants and reports are not newly calculated or summed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Beadle reports 84 recruited and 80 completed, with 37 alcohol and 43 saline; the Korean account describes 80 analysed. Candemir reports 118 ITT and 115 completed. The separate 120-person 3-arm trial and the review's 195 people are different contexts.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Recruitment, allocation, completion, time-specific assessment and analysis flow, group missingness, withdrawals and ITT definitions are needed. Differences, participants and reports are not newly calculated or summed.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Recruitment, allocation, completion, time-specific assessment and analysis flow, group missingness, withdrawals and ITT definitions are needed. Differences, participants and reports are not newly calculated or summed." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Could odor have made blinding incomplete?", "needed": "Allocation, concealment, subjective measurement and expectancy", "role": "Required", "role_reason": "Material on Allocation, concealment, subjective measurement and expectancy is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Allocation, concealment, subjective measurement and expectancy must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Allocation, concealment, who was blinded, blinding-success assessment, NRS collectors and procedures, withdrawals and revealing cues are needed. No new formal RoB2 assessment is made. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored counterview and citation record incomplete blinding due to odor. The label randomized trial alone does not establish adequate blinding of subjective nausea assessments and assessors.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Allocation, concealment, who was blinded, blinding-success assessment, NRS collectors and procedures, withdrawals and revealing cues are needed. No new formal RoB2 assessment is made.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Allocation, concealment, who was blinded, blinding-success assessment, NRS collectors and procedures, withdrawals and revealing cues are needed. No new formal RoB2 assessment is made." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "Have trial registrations and review registrations actually been read?", "needed": "Distinguishing trial and review registration from prospective plans", "role": "Required", "role_reason": "Material on Distinguishing trial and review registration from prospective plans is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Distinguishing trial and review registration from prospective plans must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Original registrations, amendments, protocols, SAPs and prospective endpoints and denominators are needed separately for trials and reviews. An identifier alone is not verification of prospective specification. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "NCT02092441 appears in the stored evidence and citation, and NCT02760069 in the Korean account. Candemir's registration is unverified. CRD42022299815 identifies April's review registration, not a clinical trial registration. No external registration or plan was read in this work.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original registrations, amendments, protocols, SAPs and prospective endpoints and denominators are needed separately for trials and reviews. An identifier alone is not verification of prospective specification.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original registrations, amendments, protocols, SAPs and prospective endpoints and denominators are needed separately for trials and reviews. An identifier alone is not verification of prospective specification." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "Are company funding, product supply, affiliations and analysis roles separated?", "needed": "Different aspects of company involvement by report", "role": "Required", "role_reason": "Material on Different aspects of company involvement by report is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Different aspects of company involvement by report must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Separate documents on financial support, product support, company affiliations and design, analysis or publication roles are needed. Conflict-of-interest or sponsorship wording alone does not establish absence across every category. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored material describes Beadle as a military institutional study without manufacturer sponsorship, Candemir as reporting no conflict of interest with detailed funding unverified, and April as academic research without manufacturer involvement. Detailed funding for NCT02760069 is absent from the Korean account.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Separate documents on financial support, product support, company affiliations and design, analysis or publication roles are needed. Conflict-of-interest or sponsorship wording alone does not establish absence across every category.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Separate documents on financial support, product support, company affiliations and design, analysis or publication roles are needed. Conflict-of-interest or sponsorship wording alone does not establish absence across every category." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "Are reports and trials included in reviews counted twice?", "needed": "Reports, original trials, participants and shared relationships", "role": "Required", "role_reason": "Material on Reports, original trials, participants and shared relationships is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Reports, original trials, participants and shared relationships must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Included-trial, time-specific analysis-population, report and cohort identification tables are needed. Reports, sheets and original numbers are not summed as unique trials, participants or independent replications. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The two subclaims share parent 3012's Beadle, Candemir and April records and the separate Korean 3-arm summary. April is a review including original trials, and the Korean account of 120 people is not a separate evidence or citation entry.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Included-trial, time-specific analysis-population, report and cohort identification tables are needed. Reports, sheets and original numbers are not summed as unique trials, participants or independent replications.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Included-trial, time-specific analysis-population, report and cohort identification tables are needed. Reports, sheets and original numbers are not summed as unique trials, participants or independent replications." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "Has the stored description of independent replication been verified?", "needed": "Candemir's supportive result versus unverified funding and prospective specification", "role": "Required", "role_reason": "Material on Candemir's supportive result versus unverified funding and prospective specification is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Candemir's supportive result versus unverified funding and prospective specification must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Original registration, prospective plans, institutions, recruitment, support and overlapping-report relationships are needed. The number of unique independent trials is unverified. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored assessment labels Candemir an independent replication while also describing its funding, registration and prospective specification as unclear. This historical wording is not converted into current verification of independence.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original registration, prospective plans, institutions, recruitment, support and overlapping-report relationships are needed. The number of unique independent trials is unverified.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original registration, prospective plans, institutions, recruitment, support and overlapping-report relationships are needed. The number of unique independent trials is unverified." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Are the different Korean and English contexts distinguished?", "needed": "The Korean 30-minute 3-arm account versus the English pooled result", "role": "Required", "role_reason": "Material on The Korean 30-minute 3-arm account versus the English pooled result is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on The Korean 30-minute 3-arm account versus the English pooled result must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Original trial and review tables, denominators, times and effects of interest need comparison. Both stored language accounts are retained without new external comparison or correction. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored Korean explanation describes NCT02760069's 30-minute within-group VAS results. The English explanation contains the 10-minute meta-analysis of two placebo-controlled trials and 195 people. They are not substituted as translations of the same report, time or between-group effect.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original trial and review tables, denominators, times and effects of interest need comparison. Both stored language accounts are retained without new external comparison or correction.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original trial and review tables, denominators, times and effects of interest need comparison. Both stored language accounts are retained without new external comparison or correction." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "Does reading a stored summary differ from reading external materials?", "needed": "Reading scope for summaries, abstracts, full texts, registrations and plans", "role": "Required", "role_reason": "Material on Reading scope for summaries, abstracts, full texts, registrations and plans is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Reading scope for summaries, abstracts, full texts, registrations and plans must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Access and reading status need separate records when actual materials are obtained and reviewed. A URL alone does not establish full-text reading, accessibility or completed review. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The complete stored assessment was read. Citation wording such as checked and cross-check incorporated describes historical work. External abstracts, full texts, registrations, protocols and SAPs remain unread in this work.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Access and reading status need separate records when actual materials are obtained and reviewed. A URL alone does not establish full-text reading, accessibility or completed review.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Access and reading status need separate records when actual materials are obtained and reviewed. A URL alone does not establish full-text reading, accessibility or completed review." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "Are adverse-event collection, denominators and exposure known?", "needed": "Harms such as dizziness, headache, cough and respiratory irritation", "role": "Supplementary", "role_reason": "Material on Harms such as dizziness, headache, cough and respiratory irritation is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on Harms such as dizziness, headache, cough and respiratory irritation must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Collection methods, events, affected people, severity, times, exposure, group denominators, discontinuation, rescue and causal-assessment data are needed. Missing numbers do not mean safe or harmless. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored safety account contains existing warnings about harms and emergency symptoms. April lists adverse events as an endpoint, but the summary lacks group event counts, collection methods, denominators and exposure. No new use or administration instructions are provided.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Collection methods, events, affected people, severity, times, exposure, group denominators, discontinuation, rescue and causal-assessment data are needed. Missing numbers do not mean safe or harmless.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Collection methods, events, affected people, severity, times, exposure, group denominators, discontinuation, rescue and causal-assessment data are needed. Missing numbers do not mean safe or harmless." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "Can a brief trial establish repeated exposure, long-term use or vulnerable-group safety?", "needed": "Brief observation versus long-term, rare harms and vulnerable populations", "role": "Supplementary", "role_reason": "Material on The boundary between brief observation and longer-term, rare harms or vulnerable groups is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on The boundary between brief observation and longer-term, rare harms or vulnerable groups must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Long-term or repeated exposure, vulnerable-group eligibility, group harm follow-up, denominators and actual exposure data are needed. No new research or searches were performed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The representative endpoint is 10 minutes, with a separate 30-minute Korean context. These are not extended to verification of safety for long-term or repeated exposure, pregnancy or respiratory vulnerability. The stored safety account is distinguished as existing warnings.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Long-term or repeated exposure, vulnerable-group eligibility, group harm follow-up, denominators and actual exposure data are needed. No new research or searches were performed.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Long-term or repeated exposure, vulnerable-group eligibility, group harm follow-up, denominators and actual exposure data are needed. No new research or searches were performed." }, { "item_id": "N28", "question_type": "Evidence condition", "question": "How are subclaim grades C and D distinguished from parent C54?", "needed": "The selected grade versus the parent score, caution status and axes", "role": "Required", "role_reason": "Material on The selected grade versus the parent score, caution status and axes is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on The selected grade versus the parent score, caution status and axes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: The boundary between subclaim and parent application must be distinguished. D is not replaced with C54, and no new subclaim score, harm grade or independence certification is created. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The acute-nausea subclaim is C and the actual-vomiting or underlying-cause-treatment subclaim is D. Individual scores, statuses and axes are absent; parent C54, caution and B/P/R1/I2/E+/B2/CX belong to the overall nausea assessment.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "The boundary between subclaim and parent application must be distinguished. D is not replaced with C54, and no new subclaim score, harm grade or independence certification is created.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The boundary between subclaim and parent application must be distinguished. D is not replaced with C54, and no new subclaim score, harm grade or independence certification is created." }, { "item_id": "N29", "question_type": "Evidence condition", "question": "Did the change from draft B to final C happen in this work?", "needed": "The stored assessment's decision history versus the current record", "role": "Required", "role_reason": "Material on The stored assessment's decision history versus the current record is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on The stored assessment's decision history versus the current record must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Any assessment change needs a separate record preserving the preceding text, event, version and reasons. This table retains stored values. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The stored decision history records draft B, final C, score 54 and cross-check incorporation. This is a historical decision, not a new reassessment from B to C in this work.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Any assessment change needs a separate record preserving the preceding text, event, version and reasons. This table retains stored values.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Any assessment change needs a separate record preserving the preceding text, event, version and reasons. This table retains stored values." }, { "item_id": "N30", "question_type": "Evidence condition", "question": "Are the evidence date, production time and corrections distinguished?", "needed": "The original evidence date and empty correction or deliberation records", "role": "Required", "role_reason": "Material on The original evidence date and empty correction or deliberation records is needed to connect the selected vomiting and underlying-cause-treatment question with controls, endpoints, times, original reports, denominators, precision and harm boundaries.", "application_exception": "Selected D and absent individual score, status and axes are retained without substituting parent C54 or separate nausea C. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.", "criterion": "Original material on The original evidence date and empty correction or deliberation records must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected vomiting and underlying-cause treatment from separate nausea, parent context and unread external material.", "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.", "condition_origin": "These are evidence conditions for the existing actual-vomiting and underlying-cause-treatment question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.", "proposed_research": "Material needed: Evidence additions, condition revisions, observation applications and assessment changes must be distinguished, preserving the preceding text and reasons for change. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04" ], "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The original evidence date is 2026-09-07. Corrections are stored as an empty list and deliberation as an empty string. The production time is not turned into a new evidence-verification date, and no nonexistent correction is invented.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Evidence additions, condition revisions, observation applications and assessment changes must be distinguished, preserving the preceding text and reasons for change.", "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Evidence additions, condition revisions, observation applications and assessment changes must be distinguished, preserving the preceding text and reasons for change." } ], "reports": [ { "report_id": "R01", "title": "Beadle KL et al. 2016", "url": "https://pubmed.ncbi.nlm.nih.gov/26679977/", "report_type": "Randomized alcohol-versus-saline odor trial; principal 10-minute nausea NRS", "existence": "This is report and bibliographic information or separate explanatory context in the preserved parent account. Current external identity, content, registration and detailed-material verification was not performed.", "acquired_read": "Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.", "study_family": "Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.", "independent_replication": "Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.", "observed_result": "The record states 84 recruited, 80 completed, 37 alcohol and 43 saline. Original 10-minute medians of 3 versus 6, difference 3 (95% CI 2 to 4), satisfaction +2 and null rescue use are retained.", "result_level": "This is a stored summary of direct NRS findings. Recruitment, completion, analysis wording and endpoint-specific denominators are distinguished; historical registration and verification narratives are not promoted into current external verification. These nausea, satisfaction and rescue findings are not converted into direct results for actual vomiting or treatment of the cause.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/26679977/" } ] }, { "report_id": "R02", "title": "Candemir H et al. 2021", "url": "https://pubmed.ncbi.nlm.nih.gov/33373914/", "report_type": "Prospective randomized placebo-controlled trial; repeated-time nausea and rescue treatment", "existence": "This is report and bibliographic information or separate explanatory context in the preserved parent account. Current external identity, content, registration and detailed-material verification was not performed.", "acquired_read": "Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.", "study_family": "Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.", "independent_replication": "Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.", "observed_result": "The report records 118 in ITT, 115 completed, nausea NRS at 2, 4 and 10 minutes and rescue treatment. The overall between-group effect from 2 minutes, P=.008, and less rescue treatment are retained without copying identical effects or CIs to each time.", "result_level": "Original independent-replication wording is retained together with unverified specific funding, registration and prespecification. No current independence certification or confirmed unique-trial total is created. Less rescue treatment is not substituted as a direct estimate of fewer vomiting events or treatment of the underlying disease.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/33373914/" } ] }, { "report_id": "R03", "title": "April MD et al. 2023", "url": "https://pubmed.ncbi.nlm.nih.gov/37076258/", "report_type": "Systematic review and meta-analysis; quantitative synthesis of included trials", "existence": "This is report and bibliographic information or separate explanatory context in the preserved parent account. Current external identity, content, registration and detailed-material verification was not performed.", "acquired_read": "Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.", "study_family": "Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.", "independent_replication": "Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.", "observed_result": "The original record retains 2 saline-controlled RCTs, 195 participants, 10-minute MD -2.18/10 (95% CI -2.76 to -1.60), MCID 1.5 and moderate certainty.", "result_level": "These are the original review's criteria and certainty narratives. Externally validated important differences, extraction from included trials and overlap remain unverified; the review is not counted as a new original trial or current official GRADE assessment. Listed vomiting, rescue and adverse-event endpoints are distinguished from quantitative nausea results; the original vomiting results table is unread.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/37076258/" } ] }, { "report_id": "R04", "title": "Separate 3-arm summary in the stored Korean account", "url": null, "report_type": "Korean context concerning NCT02760069; no separate evidence or bibliography entry", "existence": "This is report and bibliographic information or separate explanatory context in the preserved parent account. Current external identity, content, registration and detailed-material verification was not performed.", "acquired_read": "Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.", "study_family": "Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.", "independent_replication": "Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.", "observed_result": "The 120-person, 3-arm, 30-minute within-group VAS reductions are 30mm with alcohol, 32mm with ondansetron plus alcohol and 9mm with ondansetron plus saline. This remains separate Korean context without new between-group effects, CIs or NRS conversion.", "result_level": "This is preserved context from the parent Korean explanation. Detailed bibliography, an original-text URL, arm-specific analysis denominators and original between-group results are unlinked; no external link is newly inferred. These within-group nausea changes are distinguished from actual vomiting or treatment-of-cause outcomes.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review." } ], "links": [] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.", "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.", "Review incomplete": "Review of existing content remains incomplete.", "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.", "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.", "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.", "Not applicable": "Used only with an application exception and reason based on the question scope.", "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.", "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade." }, "study_overlap": { "state": "Unverified", "unique_trial_count": null, "unique_participant_count": null, "reason": "Selected actual vomiting and underlying-cause treatment, separate acute nausea and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified." }, "history": [ { "date": "2026-10-20", "kind": "Separation of public-facing pages and materials", "view_version": "1.0", "change": "Public-facing views and materials were prepared from the existing 30 items. No new clinical search, verification-status change or scoring was performed." } ], "language": "en", "translation_date": "2026-10-20" }