Isopropyl-alcohol pad × Acute ED nausea—subjective symptoms at 10 minutes

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionWhich acute-nausea question is addressed?Required	The selected question is relief of acute nausea within 10 minutes, graded C. The positive registered trial and its small, ultra-short subjective endpoint are retained together. Actual vomiting and cause treatment are separate questions. R01 R02 R03	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Selected 10-minute nausea question, original grade and note versus separate vomiting	Material needed: Original direct comparisons, arm-specific denominators, target effects, CIs and selected versus parent boundaries are needed. No new question, independence certification or subclaim score is created. This records needed materials; no new research was executed.
2	Partly verified	Full text not readStored summary read	N02 · Evidence conditionWhat is Beadle's direct 10-minute result?Required	The original 10-minute medians are 3 with alcohol versus 6 with saline, a difference of 3 (95% CI 2 to 4). These are reported values, not a new effect calculated by subtracting arm values. R01	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Original 10-minute NRS findings, difference, CI and comparison	Material needed: Scale range, direction, baseline, estimation methods, the effect targeted by the CI and arm-specific analysis denominators are needed. Findings are not transferred to other times or scales. This records needed materials; no new research was executed.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionDo recruitment, completion and arm counts share an analysis denominator?Required	The record retains 84 recruited, 80 completed, 37 alcohol and 43 saline. Analysis wording in the Korean original and completion wording in the English original are distinguished without further establishing endpoint-specific analysis stages. R01	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Beadle recruitment, completion, analysis and arm counts	Material needed: Original flow, analysis populations, nausea, satisfaction and rescue denominators and missing-data handling are needed. No new attrition or event count is calculated from differences. This records needed materials; no new research was executed.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionIs MCID 1.5 the same as an externally validated important difference?Required	April records MCID 1.5, MD -2.18/10 (95% CI -2.76 to -1.60) and moderate certainty. The parent account leaves an externally validated important difference uncertain; these levels are distinguished. R01 R03	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Prespecified criteria, review effects and external clinical importance	Material needed: MCID sources, prespecification, patient-important criteria, measurement tools, effect distributions and responder data are needed. This is not promoted into current official GRADE certification. This records needed materials; no new research was executed.
5	Partly verified	Full text not readStored summary read	N05 · Evidence conditionIs satisfaction +2 a nausea or vomiting effect?Required	Beadle's satisfaction +2 is retained as a reported result. A separate satisfaction scale and CI are unverified; this is not the same value as nausea NRS or cessation of actual vomiting. R01	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Satisfaction measures versus nausea NRS and vomiting events	Material needed: Satisfaction tools, timing, denominators, between-group estimates, CIs and prespecified hierarchy are needed. This records needed materials; no new research was executed.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionWere rescue-antiemetic findings the same in every trial?Required	Beadle records null rescue use, while Candemir records less rescue treatment. Favorable nausea findings do not establish reductions in all trials; rescue need, actual vomiting and cause treatment are distinguished. R01 R02 R03	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Rescue medication and treatment versus other endpoints	Material needed: Rescue criteria, drugs, exposure, timing, denominators, between-group effects, CIs and concurrent care are needed. This records needed materials; no new research was executed.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionWhat are Candemir's repeated-time results?Required	The record retains 118 in ITT, 115 completed, NRS at 2, 4 and 10 minutes, rescue treatment and an overall between-group effect from 2 minutes, P=.008. It is not copied as identical effects, CIs or P values at each time. R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	NRS at 2, 4 and 10 minutes and the overall between-group analysis	Material needed: Time-specific effects, CIs, denominators, repeated-measures models, multiple comparisons and prespecified hierarchy are needed. This records needed materials; no new research was executed.
8	Partly verified	Full text not readStored summary read	N08 · Evidence conditionAre 10-minute NRS and 30-minute within-group VAS the same?Required	The Korean account's 120-person, 3-arm trial records 30-minute within-group VAS reductions of 30mm with alcohol, 32mm with ondansetron plus alcohol and 9mm with ondansetron plus saline. This is distinguished from the 10-minute saline-controlled between-group NRS effect. R01 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	NCT02760069's separate 3-arm, 30-minute comparison	Material needed: Original 3-arm material, arm-specific allocation and analysis, interventions, concurrent drugs, timing, between-group VAS effects, CIs and prespecified plans are needed. No scale conversion or new between-group CI is created. This records needed materials; no new research was executed.
9	Partly verified	Full text not readStored summary read	N09 · Evidence conditionWhat do the review's 2 RCTs and 195 participants represent?Required	The original record retains 2 saline-controlled RCTs, 195 participants and a 10-minute MD of -2.18/10. Trial samples are not newly summed to certify this total, and the review is not added as a new independent RCT. R01 R02 R03	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	April synthesis, included trials and extraction denominators	Material needed: Included-trial identities, time- and scale-specific extraction denominators, overlap, meta-analysis methods, bias and certainty materials are needed. This records needed materials; no new research was executed.
10	Partly verified	Full text not readStored summary read	N10 · Evidence conditionWere within-group changes distinguished from direct between-group results?Required	Beadle's difference and CI and Candemir's overall between-group P value are distinguished as direct comparisons. The separate 120-person, 3-arm, 30-minute values are within-group changes and are not merged into the same effect. R01 R02 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Study-specific target effects and analysis levels	Material needed: Baseline adjustment, change and endpoint comparisons, models and original between-group estimates and CIs are needed. No new between-group effect is calculated by subtracting within-group values. This records needed materials; no new research was executed.
11	Partly verified	Full text not readStored summary read	N11 · Evidence conditionWere registration and subjective-endpoint limitations retained together?Required	The original note retains positive registered findings alongside small samples, a 10-minute subjective scale and blinding limitations. A registration number does not resolve all bias. R01 R02 R03	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Original prespecification narrative, small samples and ultra-short measurement	Material needed: Original registration, changes, prespecified endpoints, analyses, allocation, measurement and missing-data material are needed. Selected C is not promoted into a new grade. This records needed materials; no new research was executed.
12	Partly verified	Full text not readStored summary read	N12 · Evidence conditionDoes a brief nausea-score result establish less actual vomiting?Required	The parent states that nausea over minutes does not mean vomiting stops. Its account of null vomiting in one supporting trial is retained; trial identity and event counts remain unverified. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Subjective nausea versus separate vomiting-event evidence	Material needed: Vomiting definitions, report identity, events versus people, timing, denominators, between-group effects and CIs are needed. Nausea effects are not converted into reduced vomiting. This records needed materials; no new research was executed.
13	Partly verified	Full text not readStored summary read	N13 · Evidence conditionDoes 10-minute relief establish cause treatment or less clinical care?Required	The parent distinguishes brief nausea relief while awaiting assessment from reduced underlying diagnosis, treatment or fluid needs. Its original statement that the latter are not demonstrated is retained. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Underlying diagnosis, treatment, fluids and concurrent care boundaries	Material needed: Direct studies and denominators for cause-specific diagnosis, treatment, care, fluids and important clinical outcomes are needed. No new administration, procedure or care guidance is created. This records needed materials; no new research was executed.
14	Partly verified	Full text not readStored summary read	N14 · Evidence conditionDo short-term findings establish durability or recurrence effects?Required	The principal endpoint is 10 minutes, with a separate 30-minute result. Persistence, recurrence and repeated-exposure effects after discharge are not established, and short-term material is not labeled long-term. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	A 10-minute endpoint versus long-term and recurrent nausea	Material needed: Longer follow-up, recurrence, rescue, cause treatment, concurrent care and corresponding analysis denominators are needed. This records needed materials; no new research was executed.
15	Partly verified	Full text not readStored summary read	N15 · Evidence conditionWhich emergency-department adults were studied?Required	The parent scope concerns acute nausea in emergency-department adults. Recruitment, completion and arm counts from the representative trial do not replace full causes or eligibility criteria. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Eligibility, causes and baseline severity in acute nausea	Material needed: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. Findings are not extended to other populations or settings. This records needed materials; no new research was executed.
16	Partly verified	Full text not readStored summary read	N16 · Evidence conditionWhat are the formulation and route boundaries for the 70% pad?Required	The original intervention is brief inhalation from a 70% isopropyl-alcohol pad. Concentration is not converted into inhaled quantity, frequency or exposure; ingestion and broad skin application are distinguished. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Original formulation, concentration, exposure and intervention boundaries	Material needed: Original products, manufacturing, pad volume, exposure criteria and comparability between arms are needed. No new procedure or administration method is created. This records needed materials; no new research was executed.
17	Partly verified	Full text not readStored summary read	N17 · Evidence conditionAre saline-odor control and drug comparisons the same?Required	Beadle's saline-odor control is distinguished from NCT02760069's 120-person, 3-arm comparison involving ondansetron. Controls and results are not treated as the same effect. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Controls, concurrent drugs, rescue medication and target effects	Material needed: Arm-specific interventions, concurrent antiemetics, allocation, rescue criteria, target effects and original between-group results are needed. This records needed materials; no new research was executed.
18	Partly verified	Full text not readStored summary read	N18 · Evidence conditionWere recruitment, completion, ITT and endpoint denominators distinguished?Required	Beadle's 84 recruited, 80 completed, 37 alcohol and 43 saline, and Candemir's 118 in ITT and 115 completed are retained. A separate 120-person, 3-arm trial and the review's 195 participants are different contexts. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Trial flow and valid arm- and endpoint-specific denominators	Material needed: Recruitment, allocation, completion, time-specific assessments, analysis, arm-specific missingness and ITT definitions are needed. No new differences or participant totals are calculated. This records needed materials; no new research was executed.
19	Partly verified	Full text not readStored summary read	N19 · Evidence conditionWhat are odor-related blinding limitations?Required	The account and bibliography retain incomplete blinding due to odor. The randomized-trial label does not establish adequate subjective assessment and blinding throughout. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Allocation, concealment, subjective-score collection and expectations	Material needed: Allocation, concealment, people blinded, blinding success, NRS collectors, procedures, losses and revealing cues are needed. No new official RoB2 judgment is made. This records needed materials; no new research was executed.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionDoes a registration number mean external registration was read?Required	NCT02092441 appears in original evidence and bibliography, and NCT02760069 in the Korean account. Candemir's original registration is unverified. CRD42022299815 identifies April's review; external registration and plans were unread here. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Trial registration, review registration and prespecification material	Material needed: Each trial's and review's original registration, changes, protocol, analysis plans, prespecified endpoints and denominators must be distinguished. Numbers alone do not establish verified prespecification or identity. This records needed materials; no new research was executed.
21	Partly verified	Full text not readStored summary read	N21 · Evidence conditionWere different company-involvement items distinguished?Required	Beadle is reported as a military institutional study without manufacturer sponsorship; Candemir reports no COI with specific funding unverified; April reports academic research without manufacturer involvement. Detailed funding for the separate combined-drug comparison is unverified. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Funding, product support, affiliations, analysis and publication roles	Material needed: Original documents on financial and product support, company affiliations, design, analysis and publication roles are needed separately. One item does not establish absence of every form of involvement. This records needed materials; no new research was executed.
22	Partly verified	Full text not readStored summary read	N22 · Evidence conditionWere reports, reviews and subquestions double-counted?Required	Both subquestions share the parent's Beadle, Candemir and April reports and separate Korean comparison context. The review synthesizes included trials, and the Korean 120-person description is not a separate evidence or bibliography entry. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Reports, original trials, cohorts and shared relationships	Material needed: Included trials, time-specific analysis populations, reports and cohort identity tables are needed. Report slots, sheets and samples are not added as unique trials, participants or independent replications. This records needed materials; no new research was executed.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionWhat is the level of the original independent-replication wording?Required	The parent's independent-replication wording and unverified funding, registration and prespecification are retained together. They are not promoted into current independence certification or a confirmed unique-trial total. R01 R02 R03	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Candemir support versus funding and prespecification gaps	Material needed: Original registration, plans, institutions, recruitment, support and overlapping-report relationships are needed. Uncertain unique totals remain uncertain. This records needed materials; no new research was executed.
24	Partly verified	Full text not readStored summary read	N24 · Evidence conditionWere differing parent Korean and English contexts retained?Required	The Korean account contains NCT02760069's 30-minute within-group VAS; the English account contains a 10-minute meta-analysis of two placebo-controlled trials and 195 participants. They are not substituted for each other as translations of the same report, time or effect. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Korean 30-minute, 3-arm findings versus English synthesis	Material needed: Original trial and review result tables, denominators, times and effect comparisons are needed. Complete parent Korean and English accounts are preserved without new external comparison or correction. This records needed materials; no new research was executed.
25	Partly verified	Full text not readStored summary read	N25 · Evidence conditionDoes stored-summary reading equal external-original reading?Required	The complete stored parent summary was read. Historical verification and cross-check narratives are distinguished from actual reading here; external abstracts, full text, registration and plans remain unread. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Report-specific summary, abstract, full-text, registration and plan status	Material needed: Actual acquisition or review requires separate identity, access and reading-level records. A URL alone does not establish reading, successful access or completed content review. This records needed materials; no new research was executed.
26	Partly verified	Full text not readStored summary read	N26 · Evidence conditionAre adverse-event collection, denominators and exposure known?Supplementary	Parent safety cautions are preserved unchanged. April lists adverse events, but arm-specific event counts, collection methods, denominators and exposure quantities are unverified. Missing numbers are not converted into safety or absence of events. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Harm events, collection, severity, exposure and discontinuation	Material needed: Active collection, events versus affected people, severity, onset, exposure, arm-specific denominators, discontinuation, rescue and causality-assessment material are needed. This records needed materials; no new research was executed.
27	Partly verified	Full text not readStored summary read	N27 · Evidence conditionCan repeated or long-term exposure and vulnerable groups be assessed?Supplementary	The principal 10-minute and separate 30-minute results are not extended into safety verification for long-term or repeated exposure, pregnancy or respiratory vulnerability. Parent cautions are not turned into new procedure guidance. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Brief observation versus long-term, rare harms and vulnerable populations	Material needed: Long-term and repeated exposure, vulnerable-group eligibility, arm-specific harm follow-up, denominators and actual exposure material are needed. This records needed materials; no new research was executed.
28	Partly verified	Full text not readStored summary read	N28 · Evidence conditionHow do selected C, separate D and parent C54 differ?Required	Acute nausea is C and actual vomiting or cause treatment is D. Individual scores, status and axes are absent; parent C54, Caution and B/P/R1/I2/E+/B2/CX belong to the overall context. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Selected and separate subclaim grades versus parent score, status and axes	Material needed: Subclaim and parent records and application boundaries must be distinguished. Parent values do not overwrite subclaim D or create new scores, harm grades or independence certification. This records needed materials; no new research was executed.
29	Partly verified	Full text not readStored summary read	N29 · Evidence conditionAre historical draft B and final C a new reassessment?Required	The parent's draft B, final C, 54 points and cross-check record are historical. The grade was not reassessed in this production. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Original grade-decision history versus current production	Material needed: A requested verdict change requires preservation of complete originals, events, versions and reasons. This work retains original values. This records needed materials; no new research was executed.
30	Partly verified	Full text not readStored summary read	N30 · Evidence conditionWere original dates, corrections and production times separated?Required	The original date is 2026-09-07, corrections are an empty array and deliberation an empty string. The current production time does not become an evidence-verification date, and no absent correction is invented. R01 R02 R03 R04	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Historical evidence date, empty corrections and deliberation versus new changes	Material needed: Material additions, condition revisions, observation application and verdict changes must remain separate events, preserving previous originals. This records needed materials; no new research was executed.

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30 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-09-07
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: The question concerns acute nausea in emergency-department adults. Causes, detailed eligibility, baseline severity and valid endpoint-specific denominators remain unverified. Findings are not extended to other populations or settings.
Ingredient, formulation and route: The original intervention is brief inhalation from a 70% isopropyl-alcohol pad. The recorded route is retained and distinguished from ingestion or broad skin application.
Dose: 70% is the original concentration. Actual inhaled quantity, frequency and quantitative exposure remain unverified; concentration is not converted into a dose, and no new procedure or administration guidance is created.
Comparator: Saline-odor control is central, while the separate 3-arm comparison, ondansetron combinations and rescue medication are distinguished.
Measured outcome: The selected endpoint is 10-minute nausea NRS. Satisfaction, rescue use, actual vomiting and cause treatment are distinguished; separate 30-minute within-group VAS findings are not turned into the same between-group effect.
Duration: The principal 10-minute endpoint, measurements at 2 and 4 minutes and the separate 30-minute comparison are distinguished. Persistence, recurrence and repeated-exposure effects after discharge remain unverified.
Questions outside this scope: Extending 10-minute subjective nausea to reduced actual vomiting, cause treatment or less clinical care or fluids; Creating new between-group effects, CIs or NRS conversions from 30-minute within-group VAS; Converting reported null findings into precise absence of effect, equivalence or safety certification; Adding original trials, reviews, shared reports and sheets as unique trials, participants or independent replications; Inheriting registration numbers, historical cross-checks, prespecified MCID or review certainty as current external review or official certification; Creating new procedures, administration or individual-care guidance from original concentration, route or safety cautions

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

R01 · Beadle KL et al. 2016

PubMed

Material type: Randomized alcohol-versus-saline odor trial; principal 10-minute nausea NRS
Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.
Findings recorded in the stored summary: The record states 84 recruited, 80 completed, 37 alcohol and 43 saline. Original 10-minute medians of 3 versus 6, difference 3 (95% CI 2 to 4), satisfaction +2 and null rescue use are retained.
Record level: This is a stored summary of direct NRS findings. Recruitment, completion, analysis wording and endpoint-specific denominators are distinguished; historical registration and verification narratives are not promoted into current external verification.
Study overlap and independent replication: Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.

R02 · Candemir H et al. 2021

PubMed

Material type: Prospective randomized placebo-controlled trial; repeated-time nausea and rescue treatment
Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.
Findings recorded in the stored summary: The report records 118 in ITT, 115 completed, nausea NRS at 2, 4 and 10 minutes and rescue treatment. The overall between-group effect from 2 minutes, P=.008, and less rescue treatment are retained without copying identical effects or CIs to each time.
Record level: Original independent-replication wording is retained together with unverified specific funding, registration and prespecification. No current independence certification or confirmed unique-trial total is created.
Study overlap and independent replication: Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.

R03 · April MD et al. 2023

PubMed

Material type: Systematic review and meta-analysis; quantitative synthesis of included trials
Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.
Findings recorded in the stored summary: The original record retains 2 saline-controlled RCTs, 195 participants, 10-minute MD -2.18/10 (95% CI -2.76 to -1.60), MCID 1.5 and moderate certainty.
Record level: These are the original review's criteria and certainty narratives. Externally validated important differences, extraction from included trials and overlap remain unverified; the review is not counted as a new original trial or current official GRADE assessment.
Study overlap and independent replication: Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.

R04 · Separate 3-arm summary in the stored Korean account

Material type: Korean context concerning NCT02760069; no separate evidence or bibliography entry
Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.
Findings recorded in the stored summary: The 120-person, 3-arm, 30-minute within-group VAS reductions are 30mm with alcohol, 32mm with ondansetron plus alcohol and 9mm with ondansetron plus saline. This remains separate Korean context without new between-group effects, CIs or NRS conversion.
Record level: This is preserved context from the parent Korean explanation. Detailed bibliography, an original-text URL, arm-specific analysis denominators and original between-group results are unlinked; no external link is newly inferred.
Study overlap and independent replication: Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review.

Report counts versus independent study counts

Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which acute-nausea question is addressed?

Required materials and conditions: Selected 10-minute nausea question, original grade and note versus separate vomiting
Conditions for verification: Original material on Selected 10-minute nausea question, original grade and note versus separate vomiting must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Selected 10-minute nausea question, original grade and note versus separate vomiting is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N02 · What is Beadle's direct 10-minute result?

Required materials and conditions: Original 10-minute NRS findings, difference, CI and comparison
Conditions for verification: Original material on Original 10-minute NRS findings, difference, CI and comparison must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Original 10-minute NRS findings, difference, CI and comparison is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N03 · Do recruitment, completion and arm counts share an analysis denominator?

Required materials and conditions: Beadle recruitment, completion, analysis and arm counts
Conditions for verification: Original material on Beadle recruitment, completion, analysis and arm counts must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Beadle recruitment, completion, analysis and arm counts is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N04 · Is MCID 1.5 the same as an externally validated important difference?

Required materials and conditions: Prespecified criteria, review effects and external clinical importance
Conditions for verification: Original material on Prespecified criteria, review effects and external clinical importance must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Prespecified criteria, review effects and external clinical importance is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N05 · Is satisfaction +2 a nausea or vomiting effect?

Required materials and conditions: Satisfaction measures versus nausea NRS and vomiting events
Conditions for verification: Original material on Satisfaction measures versus nausea NRS and vomiting events must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Satisfaction measures versus nausea NRS and vomiting events is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N06 · Were rescue-antiemetic findings the same in every trial?

Required materials and conditions: Rescue medication and treatment versus other endpoints
Conditions for verification: Original material on Rescue medication and treatment versus other endpoints must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Rescue medication and treatment versus other endpoints is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N07 · What are Candemir's repeated-time results?

Required materials and conditions: NRS at 2, 4 and 10 minutes and the overall between-group analysis
Conditions for verification: Original material on NRS at 2, 4 and 10 minutes and the overall between-group analysis must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on NRS at 2, 4 and 10 minutes and the overall between-group analysis is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N08 · Are 10-minute NRS and 30-minute within-group VAS the same?

Required materials and conditions: NCT02760069's separate 3-arm, 30-minute comparison
Conditions for verification: Original material on NCT02760069's separate 3-arm, 30-minute comparison must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on NCT02760069's separate 3-arm, 30-minute comparison is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N09 · What do the review's 2 RCTs and 195 participants represent?

Required materials and conditions: April synthesis, included trials and extraction denominators
Conditions for verification: Original material on April synthesis, included trials and extraction denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on April synthesis, included trials and extraction denominators is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N10 · Were within-group changes distinguished from direct between-group results?

Required materials and conditions: Study-specific target effects and analysis levels
Conditions for verification: Original material on Study-specific target effects and analysis levels must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Study-specific target effects and analysis levels is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N11 · Were registration and subjective-endpoint limitations retained together?

Required materials and conditions: Original prespecification narrative, small samples and ultra-short measurement
Conditions for verification: Original material on Original prespecification narrative, small samples and ultra-short measurement must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Original prespecification narrative, small samples and ultra-short measurement is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N12 · Does a brief nausea-score result establish less actual vomiting?

Required materials and conditions: Subjective nausea versus separate vomiting-event evidence
Conditions for verification: Original material on Subjective nausea versus separate vomiting-event evidence must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Subjective nausea versus separate vomiting-event evidence is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N13 · Does 10-minute relief establish cause treatment or less clinical care?

Required materials and conditions: Underlying diagnosis, treatment, fluids and concurrent care boundaries
Conditions for verification: Original material on Underlying diagnosis, treatment, fluids and concurrent care boundaries must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Underlying diagnosis, treatment, fluids and concurrent care boundaries is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N14 · Do short-term findings establish durability or recurrence effects?

Required materials and conditions: A 10-minute endpoint versus long-term and recurrent nausea
Conditions for verification: Original material on A 10-minute endpoint versus long-term and recurrent nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on A 10-minute endpoint versus long-term and recurrent nausea is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N15 · Which emergency-department adults were studied?

Required materials and conditions: Eligibility, causes and baseline severity in acute nausea
Conditions for verification: Original material on Eligibility, causes and baseline severity in acute nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Eligibility, causes and baseline severity in acute nausea is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N16 · What are the formulation and route boundaries for the 70% pad?

Required materials and conditions: Original formulation, concentration, exposure and intervention boundaries
Conditions for verification: Original material on Original formulation, concentration, exposure and intervention boundaries must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Original formulation, concentration, exposure and intervention boundaries is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N17 · Are saline-odor control and drug comparisons the same?

Required materials and conditions: Controls, concurrent drugs, rescue medication and target effects
Conditions for verification: Original material on Controls, concurrent drugs, rescue medication and target effects must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Controls, concurrent drugs, rescue medication and target effects is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N18 · Were recruitment, completion, ITT and endpoint denominators distinguished?

Required materials and conditions: Trial flow and valid arm- and endpoint-specific denominators
Conditions for verification: Original material on Trial flow and valid arm- and endpoint-specific denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Trial flow and valid arm- and endpoint-specific denominators is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N19 · What are odor-related blinding limitations?

Required materials and conditions: Allocation, concealment, subjective-score collection and expectations
Conditions for verification: Original material on Allocation, concealment, subjective-score collection and expectations must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Allocation, concealment, subjective-score collection and expectations is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N20 · Does a registration number mean external registration was read?

Required materials and conditions: Trial registration, review registration and prespecification material
Conditions for verification: Original material on Trial registration, review registration and prespecification material must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Trial registration, review registration and prespecification material is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N21 · Were different company-involvement items distinguished?

Required materials and conditions: Funding, product support, affiliations, analysis and publication roles
Conditions for verification: Original material on Funding, product support, affiliations, analysis and publication roles must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Funding, product support, affiliations, analysis and publication roles is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N22 · Were reports, reviews and subquestions double-counted?

Required materials and conditions: Reports, original trials, cohorts and shared relationships
Conditions for verification: Original material on Reports, original trials, cohorts and shared relationships must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Reports, original trials, cohorts and shared relationships is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N23 · What is the level of the original independent-replication wording?

Required materials and conditions: Candemir support versus funding and prespecification gaps
Conditions for verification: Original material on Candemir support versus funding and prespecification gaps must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Candemir support versus funding and prespecification gaps is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N24 · Were differing parent Korean and English contexts retained?

Required materials and conditions: Korean 30-minute, 3-arm findings versus English synthesis
Conditions for verification: Original material on Korean 30-minute, 3-arm findings versus English synthesis must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Korean 30-minute, 3-arm findings versus English synthesis is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N25 · Does stored-summary reading equal external-original reading?

Required materials and conditions: Report-specific summary, abstract, full-text, registration and plan status
Conditions for verification: Original material on Report-specific summary, abstract, full-text, registration and plan status must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Report-specific summary, abstract, full-text, registration and plan status is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N26 · Are adverse-event collection, denominators and exposure known?

Required materials and conditions: Harm events, collection, severity, exposure and discontinuation
Conditions for verification: Original material on Harm events, collection, severity, exposure and discontinuation must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Supplementary
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Harm events, collection, severity, exposure and discontinuation is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N27 · Can repeated or long-term exposure and vulnerable groups be assessed?

Required materials and conditions: Brief observation versus long-term, rare harms and vulnerable populations
Conditions for verification: Original material on Brief observation versus long-term, rare harms and vulnerable populations must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Supplementary
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Brief observation versus long-term, rare harms and vulnerable populations is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N28 · How do selected C, separate D and parent C54 differ?

Required materials and conditions: Selected and separate subclaim grades versus parent score, status and axes
Conditions for verification: Original material on Selected and separate subclaim grades versus parent score, status and axes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Selected and separate subclaim grades versus parent score, status and axes is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N29 · Are historical draft B and final C a new reassessment?

Required materials and conditions: Original grade-decision history versus current production
Conditions for verification: Original material on Original grade-decision history versus current production must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Original grade-decision history versus current production is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N30 · Were original dates, corrections and production times separated?

Required materials and conditions: Historical evidence date, empty corrections and deliberation versus new changes
Conditions for verification: Original material on Historical evidence date, empty corrections and deliberation versus new changes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Requirement and applicability: Required
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Why this condition is needed: Material on Historical evidence date, empty corrections and deliberation versus new changes is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

What the statuses mean

Partly verified: Partial information from the stored summary is linked; detailed originals and content review remain incomplete.
Unverified: Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.
Review incomplete: Review of existing content remains incomplete.
Met: This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.
Not reported: Unreported within material actually read. Unread external material is not relabeled as unreported.
Inaccessible: This means actual access failure. External access was not attempted in this work, so this state was not assigned.
Not applicable: Used only with an application exception and reason based on the question scope.
Conflicting data: This requires actual comparison of materials; no new conflict judgment was made in this work.
Insufficient evidence for the conditions: This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade.

Change history

2026-10-20 · Public page/material version 1.0

Public-facing views and materials were prepared from the existing 30 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-09-07) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which acute-nausea question is addressed?

Current findings: The selected question is relief of acute nausea within 10 minutes, graded C. The positive registered trial and its small, ultra-short subjective endpoint are retained together. Actual vomiting and cause treatment are separate questions.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original direct comparisons, arm-specific denominators, target effects, CIs and selected versus parent boundaries are needed. No new question, independence certification or subclaim score is created.
Required materials and conditions: Selected 10-minute nausea question, original grade and note versus separate vomiting
Materials to obtain first: Original direct comparisons, arm-specific denominators, target effects, CIs and selected versus parent boundaries are needed. No new question, independence certification or subclaim score is created.
Further research: Material needed: Original direct comparisons, arm-specific denominators, target effects, CIs and selected versus parent boundaries are needed. No new question, independence certification or subclaim score is created. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Selected 10-minute nausea question, original grade and note versus separate vomiting must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Selected 10-minute nausea question, original grade and note versus separate vomiting is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03

N02 · What is Beadle's direct 10-minute result?

Current findings: The original 10-minute medians are 3 with alcohol versus 6 with saline, a difference of 3 (95% CI 2 to 4). These are reported values, not a new effect calculated by subtracting arm values.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Scale range, direction, baseline, estimation methods, the effect targeted by the CI and arm-specific analysis denominators are needed. Findings are not transferred to other times or scales.
Required materials and conditions: Original 10-minute NRS findings, difference, CI and comparison
Materials to obtain first: Scale range, direction, baseline, estimation methods, the effect targeted by the CI and arm-specific analysis denominators are needed. Findings are not transferred to other times or scales.
Further research: Material needed: Scale range, direction, baseline, estimation methods, the effect targeted by the CI and arm-specific analysis denominators are needed. Findings are not transferred to other times or scales. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Original 10-minute NRS findings, difference, CI and comparison must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Original 10-minute NRS findings, difference, CI and comparison is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01

N03 · Do recruitment, completion and arm counts share an analysis denominator?

Current findings: The record retains 84 recruited, 80 completed, 37 alcohol and 43 saline. Analysis wording in the Korean original and completion wording in the English original are distinguished without further establishing endpoint-specific analysis stages.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original flow, analysis populations, nausea, satisfaction and rescue denominators and missing-data handling are needed. No new attrition or event count is calculated from differences.
Required materials and conditions: Beadle recruitment, completion, analysis and arm counts
Materials to obtain first: Original flow, analysis populations, nausea, satisfaction and rescue denominators and missing-data handling are needed. No new attrition or event count is calculated from differences.
Further research: Material needed: Original flow, analysis populations, nausea, satisfaction and rescue denominators and missing-data handling are needed. No new attrition or event count is calculated from differences. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Beadle recruitment, completion, analysis and arm counts must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Beadle recruitment, completion, analysis and arm counts is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01

N04 · Is MCID 1.5 the same as an externally validated important difference?

Current findings: April records MCID 1.5, MD -2.18/10 (95% CI -2.76 to -1.60) and moderate certainty. The parent account leaves an externally validated important difference uncertain; these levels are distinguished.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: MCID sources, prespecification, patient-important criteria, measurement tools, effect distributions and responder data are needed. This is not promoted into current official GRADE certification.
Required materials and conditions: Prespecified criteria, review effects and external clinical importance
Materials to obtain first: MCID sources, prespecification, patient-important criteria, measurement tools, effect distributions and responder data are needed. This is not promoted into current official GRADE certification.
Further research: Material needed: MCID sources, prespecification, patient-important criteria, measurement tools, effect distributions and responder data are needed. This is not promoted into current official GRADE certification. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Prespecified criteria, review effects and external clinical importance must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Prespecified criteria, review effects and external clinical importance is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R03

N05 · Is satisfaction +2 a nausea or vomiting effect?

Current findings: Beadle's satisfaction +2 is retained as a reported result. A separate satisfaction scale and CI are unverified; this is not the same value as nausea NRS or cessation of actual vomiting.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Satisfaction tools, timing, denominators, between-group estimates, CIs and prespecified hierarchy are needed.
Required materials and conditions: Satisfaction measures versus nausea NRS and vomiting events
Materials to obtain first: Satisfaction tools, timing, denominators, between-group estimates, CIs and prespecified hierarchy are needed.
Further research: Material needed: Satisfaction tools, timing, denominators, between-group estimates, CIs and prespecified hierarchy are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Satisfaction measures versus nausea NRS and vomiting events must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Satisfaction measures versus nausea NRS and vomiting events is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01

N06 · Were rescue-antiemetic findings the same in every trial?

Current findings: Beadle records null rescue use, while Candemir records less rescue treatment. Favorable nausea findings do not establish reductions in all trials; rescue need, actual vomiting and cause treatment are distinguished.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Rescue criteria, drugs, exposure, timing, denominators, between-group effects, CIs and concurrent care are needed.
Required materials and conditions: Rescue medication and treatment versus other endpoints
Materials to obtain first: Rescue criteria, drugs, exposure, timing, denominators, between-group effects, CIs and concurrent care are needed.
Further research: Material needed: Rescue criteria, drugs, exposure, timing, denominators, between-group effects, CIs and concurrent care are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Rescue medication and treatment versus other endpoints must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Rescue medication and treatment versus other endpoints is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03

N07 · What are Candemir's repeated-time results?

Current findings: The record retains 118 in ITT, 115 completed, NRS at 2, 4 and 10 minutes, rescue treatment and an overall between-group effect from 2 minutes, P=.008. It is not copied as identical effects, CIs or P values at each time.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Time-specific effects, CIs, denominators, repeated-measures models, multiple comparisons and prespecified hierarchy are needed.
Required materials and conditions: NRS at 2, 4 and 10 minutes and the overall between-group analysis
Materials to obtain first: Time-specific effects, CIs, denominators, repeated-measures models, multiple comparisons and prespecified hierarchy are needed.
Further research: Material needed: Time-specific effects, CIs, denominators, repeated-measures models, multiple comparisons and prespecified hierarchy are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on NRS at 2, 4 and 10 minutes and the overall between-group analysis must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on NRS at 2, 4 and 10 minutes and the overall between-group analysis is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R02

N08 · Are 10-minute NRS and 30-minute within-group VAS the same?

Current findings: The Korean account's 120-person, 3-arm trial records 30-minute within-group VAS reductions of 30mm with alcohol, 32mm with ondansetron plus alcohol and 9mm with ondansetron plus saline. This is distinguished from the 10-minute saline-controlled between-group NRS effect.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original 3-arm material, arm-specific allocation and analysis, interventions, concurrent drugs, timing, between-group VAS effects, CIs and prespecified plans are needed. No scale conversion or new between-group CI is created.
Required materials and conditions: NCT02760069's separate 3-arm, 30-minute comparison
Materials to obtain first: Original 3-arm material, arm-specific allocation and analysis, interventions, concurrent drugs, timing, between-group VAS effects, CIs and prespecified plans are needed. No scale conversion or new between-group CI is created.
Further research: Material needed: Original 3-arm material, arm-specific allocation and analysis, interventions, concurrent drugs, timing, between-group VAS effects, CIs and prespecified plans are needed. No scale conversion or new between-group CI is created. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on NCT02760069's separate 3-arm, 30-minute comparison must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on NCT02760069's separate 3-arm, 30-minute comparison is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R04

N09 · What do the review's 2 RCTs and 195 participants represent?

Current findings: The original record retains 2 saline-controlled RCTs, 195 participants and a 10-minute MD of -2.18/10. Trial samples are not newly summed to certify this total, and the review is not added as a new independent RCT.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Included-trial identities, time- and scale-specific extraction denominators, overlap, meta-analysis methods, bias and certainty materials are needed.
Required materials and conditions: April synthesis, included trials and extraction denominators
Materials to obtain first: Included-trial identities, time- and scale-specific extraction denominators, overlap, meta-analysis methods, bias and certainty materials are needed.
Further research: Material needed: Included-trial identities, time- and scale-specific extraction denominators, overlap, meta-analysis methods, bias and certainty materials are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on April synthesis, included trials and extraction denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on April synthesis, included trials and extraction denominators is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03

N10 · Were within-group changes distinguished from direct between-group results?

Current findings: Beadle's difference and CI and Candemir's overall between-group P value are distinguished as direct comparisons. The separate 120-person, 3-arm, 30-minute values are within-group changes and are not merged into the same effect.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Baseline adjustment, change and endpoint comparisons, models and original between-group estimates and CIs are needed. No new between-group effect is calculated by subtracting within-group values.
Required materials and conditions: Study-specific target effects and analysis levels
Materials to obtain first: Baseline adjustment, change and endpoint comparisons, models and original between-group estimates and CIs are needed. No new between-group effect is calculated by subtracting within-group values.
Further research: Material needed: Baseline adjustment, change and endpoint comparisons, models and original between-group estimates and CIs are needed. No new between-group effect is calculated by subtracting within-group values. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Study-specific target effects and analysis levels must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Study-specific target effects and analysis levels is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R04

N11 · Were registration and subjective-endpoint limitations retained together?

Current findings: The original note retains positive registered findings alongside small samples, a 10-minute subjective scale and blinding limitations. A registration number does not resolve all bias.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original registration, changes, prespecified endpoints, analyses, allocation, measurement and missing-data material are needed. Selected C is not promoted into a new grade.
Required materials and conditions: Original prespecification narrative, small samples and ultra-short measurement
Materials to obtain first: Original registration, changes, prespecified endpoints, analyses, allocation, measurement and missing-data material are needed. Selected C is not promoted into a new grade.
Further research: Material needed: Original registration, changes, prespecified endpoints, analyses, allocation, measurement and missing-data material are needed. Selected C is not promoted into a new grade. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Original prespecification narrative, small samples and ultra-short measurement must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Original prespecification narrative, small samples and ultra-short measurement is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03

N12 · Does a brief nausea-score result establish less actual vomiting?

Current findings: The parent states that nausea over minutes does not mean vomiting stops. Its account of null vomiting in one supporting trial is retained; trial identity and event counts remain unverified.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Vomiting definitions, report identity, events versus people, timing, denominators, between-group effects and CIs are needed. Nausea effects are not converted into reduced vomiting.
Required materials and conditions: Subjective nausea versus separate vomiting-event evidence
Materials to obtain first: Vomiting definitions, report identity, events versus people, timing, denominators, between-group effects and CIs are needed. Nausea effects are not converted into reduced vomiting.
Further research: Material needed: Vomiting definitions, report identity, events versus people, timing, denominators, between-group effects and CIs are needed. Nausea effects are not converted into reduced vomiting. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Subjective nausea versus separate vomiting-event evidence must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Subjective nausea versus separate vomiting-event evidence is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N13 · Does 10-minute relief establish cause treatment or less clinical care?

Current findings: The parent distinguishes brief nausea relief while awaiting assessment from reduced underlying diagnosis, treatment or fluid needs. Its original statement that the latter are not demonstrated is retained.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Direct studies and denominators for cause-specific diagnosis, treatment, care, fluids and important clinical outcomes are needed. No new administration, procedure or care guidance is created.
Required materials and conditions: Underlying diagnosis, treatment, fluids and concurrent care boundaries
Materials to obtain first: Direct studies and denominators for cause-specific diagnosis, treatment, care, fluids and important clinical outcomes are needed. No new administration, procedure or care guidance is created.
Further research: Material needed: Direct studies and denominators for cause-specific diagnosis, treatment, care, fluids and important clinical outcomes are needed. No new administration, procedure or care guidance is created. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Underlying diagnosis, treatment, fluids and concurrent care boundaries must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Underlying diagnosis, treatment, fluids and concurrent care boundaries is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N14 · Do short-term findings establish durability or recurrence effects?

Current findings: The principal endpoint is 10 minutes, with a separate 30-minute result. Persistence, recurrence and repeated-exposure effects after discharge are not established, and short-term material is not labeled long-term.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Longer follow-up, recurrence, rescue, cause treatment, concurrent care and corresponding analysis denominators are needed.
Required materials and conditions: A 10-minute endpoint versus long-term and recurrent nausea
Materials to obtain first: Longer follow-up, recurrence, rescue, cause treatment, concurrent care and corresponding analysis denominators are needed.
Further research: Material needed: Longer follow-up, recurrence, rescue, cause treatment, concurrent care and corresponding analysis denominators are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on A 10-minute endpoint versus long-term and recurrent nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on A 10-minute endpoint versus long-term and recurrent nausea is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N15 · Which emergency-department adults were studied?

Current findings: The parent scope concerns acute nausea in emergency-department adults. Recruitment, completion and arm counts from the representative trial do not replace full causes or eligibility criteria.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. Findings are not extended to other populations or settings.
Required materials and conditions: Eligibility, causes and baseline severity in acute nausea
Materials to obtain first: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. Findings are not extended to other populations or settings.
Further research: Material needed: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. Findings are not extended to other populations or settings. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Eligibility, causes and baseline severity in acute nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Eligibility, causes and baseline severity in acute nausea is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N16 · What are the formulation and route boundaries for the 70% pad?

Current findings: The original intervention is brief inhalation from a 70% isopropyl-alcohol pad. Concentration is not converted into inhaled quantity, frequency or exposure; ingestion and broad skin application are distinguished.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original products, manufacturing, pad volume, exposure criteria and comparability between arms are needed. No new procedure or administration method is created.
Required materials and conditions: Original formulation, concentration, exposure and intervention boundaries
Materials to obtain first: Original products, manufacturing, pad volume, exposure criteria and comparability between arms are needed. No new procedure or administration method is created.
Further research: Material needed: Original products, manufacturing, pad volume, exposure criteria and comparability between arms are needed. No new procedure or administration method is created. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Original formulation, concentration, exposure and intervention boundaries must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Original formulation, concentration, exposure and intervention boundaries is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N17 · Are saline-odor control and drug comparisons the same?

Current findings: Beadle's saline-odor control is distinguished from NCT02760069's 120-person, 3-arm comparison involving ondansetron. Controls and results are not treated as the same effect.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Arm-specific interventions, concurrent antiemetics, allocation, rescue criteria, target effects and original between-group results are needed.
Required materials and conditions: Controls, concurrent drugs, rescue medication and target effects
Materials to obtain first: Arm-specific interventions, concurrent antiemetics, allocation, rescue criteria, target effects and original between-group results are needed.
Further research: Material needed: Arm-specific interventions, concurrent antiemetics, allocation, rescue criteria, target effects and original between-group results are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Controls, concurrent drugs, rescue medication and target effects must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Controls, concurrent drugs, rescue medication and target effects is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N18 · Were recruitment, completion, ITT and endpoint denominators distinguished?

Current findings: Beadle's 84 recruited, 80 completed, 37 alcohol and 43 saline, and Candemir's 118 in ITT and 115 completed are retained. A separate 120-person, 3-arm trial and the review's 195 participants are different contexts.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Recruitment, allocation, completion, time-specific assessments, analysis, arm-specific missingness and ITT definitions are needed. No new differences or participant totals are calculated.
Required materials and conditions: Trial flow and valid arm- and endpoint-specific denominators
Materials to obtain first: Recruitment, allocation, completion, time-specific assessments, analysis, arm-specific missingness and ITT definitions are needed. No new differences or participant totals are calculated.
Further research: Material needed: Recruitment, allocation, completion, time-specific assessments, analysis, arm-specific missingness and ITT definitions are needed. No new differences or participant totals are calculated. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Trial flow and valid arm- and endpoint-specific denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Trial flow and valid arm- and endpoint-specific denominators is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N19 · What are odor-related blinding limitations?

Current findings: The account and bibliography retain incomplete blinding due to odor. The randomized-trial label does not establish adequate subjective assessment and blinding throughout.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Allocation, concealment, people blinded, blinding success, NRS collectors, procedures, losses and revealing cues are needed. No new official RoB2 judgment is made.
Required materials and conditions: Allocation, concealment, subjective-score collection and expectations
Materials to obtain first: Allocation, concealment, people blinded, blinding success, NRS collectors, procedures, losses and revealing cues are needed. No new official RoB2 judgment is made.
Further research: Material needed: Allocation, concealment, people blinded, blinding success, NRS collectors, procedures, losses and revealing cues are needed. No new official RoB2 judgment is made. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Allocation, concealment, subjective-score collection and expectations must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Allocation, concealment, subjective-score collection and expectations is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N20 · Does a registration number mean external registration was read?

Current findings: NCT02092441 appears in original evidence and bibliography, and NCT02760069 in the Korean account. Candemir's original registration is unverified. CRD42022299815 identifies April's review; external registration and plans were unread here.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Each trial's and review's original registration, changes, protocol, analysis plans, prespecified endpoints and denominators must be distinguished. Numbers alone do not establish verified prespecification or identity.
Required materials and conditions: Trial registration, review registration and prespecification material
Materials to obtain first: Each trial's and review's original registration, changes, protocol, analysis plans, prespecified endpoints and denominators must be distinguished. Numbers alone do not establish verified prespecification or identity.
Further research: Material needed: Each trial's and review's original registration, changes, protocol, analysis plans, prespecified endpoints and denominators must be distinguished. Numbers alone do not establish verified prespecification or identity. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Trial registration, review registration and prespecification material must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Trial registration, review registration and prespecification material is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N21 · Were different company-involvement items distinguished?

Current findings: Beadle is reported as a military institutional study without manufacturer sponsorship; Candemir reports no COI with specific funding unverified; April reports academic research without manufacturer involvement. Detailed funding for the separate combined-drug comparison is unverified.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original documents on financial and product support, company affiliations, design, analysis and publication roles are needed separately. One item does not establish absence of every form of involvement.
Required materials and conditions: Funding, product support, affiliations, analysis and publication roles
Materials to obtain first: Original documents on financial and product support, company affiliations, design, analysis and publication roles are needed separately. One item does not establish absence of every form of involvement.
Further research: Material needed: Original documents on financial and product support, company affiliations, design, analysis and publication roles are needed separately. One item does not establish absence of every form of involvement. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Funding, product support, affiliations, analysis and publication roles must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Funding, product support, affiliations, analysis and publication roles is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N22 · Were reports, reviews and subquestions double-counted?

Current findings: Both subquestions share the parent's Beadle, Candemir and April reports and separate Korean comparison context. The review synthesizes included trials, and the Korean 120-person description is not a separate evidence or bibliography entry.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Included trials, time-specific analysis populations, reports and cohort identity tables are needed. Report slots, sheets and samples are not added as unique trials, participants or independent replications.
Required materials and conditions: Reports, original trials, cohorts and shared relationships
Materials to obtain first: Included trials, time-specific analysis populations, reports and cohort identity tables are needed. Report slots, sheets and samples are not added as unique trials, participants or independent replications.
Further research: Material needed: Included trials, time-specific analysis populations, reports and cohort identity tables are needed. Report slots, sheets and samples are not added as unique trials, participants or independent replications. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Reports, original trials, cohorts and shared relationships must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Reports, original trials, cohorts and shared relationships is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N23 · What is the level of the original independent-replication wording?

Current findings: The parent's independent-replication wording and unverified funding, registration and prespecification are retained together. They are not promoted into current independence certification or a confirmed unique-trial total.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original registration, plans, institutions, recruitment, support and overlapping-report relationships are needed. Uncertain unique totals remain uncertain.
Required materials and conditions: Candemir support versus funding and prespecification gaps
Materials to obtain first: Original registration, plans, institutions, recruitment, support and overlapping-report relationships are needed. Uncertain unique totals remain uncertain.
Further research: Material needed: Original registration, plans, institutions, recruitment, support and overlapping-report relationships are needed. Uncertain unique totals remain uncertain. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Candemir support versus funding and prespecification gaps must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Candemir support versus funding and prespecification gaps is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03

N24 · Were differing parent Korean and English contexts retained?

Current findings: The Korean account contains NCT02760069's 30-minute within-group VAS; the English account contains a 10-minute meta-analysis of two placebo-controlled trials and 195 participants. They are not substituted for each other as translations of the same report, time or effect.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original trial and review result tables, denominators, times and effect comparisons are needed. Complete parent Korean and English accounts are preserved without new external comparison or correction.
Required materials and conditions: Korean 30-minute, 3-arm findings versus English synthesis
Materials to obtain first: Original trial and review result tables, denominators, times and effect comparisons are needed. Complete parent Korean and English accounts are preserved without new external comparison or correction.
Further research: Material needed: Original trial and review result tables, denominators, times and effect comparisons are needed. Complete parent Korean and English accounts are preserved without new external comparison or correction. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Korean 30-minute, 3-arm findings versus English synthesis must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Korean 30-minute, 3-arm findings versus English synthesis is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N25 · Does stored-summary reading equal external-original reading?

Current findings: The complete stored parent summary was read. Historical verification and cross-check narratives are distinguished from actual reading here; external abstracts, full text, registration and plans remain unread.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Actual acquisition or review requires separate identity, access and reading-level records. A URL alone does not establish reading, successful access or completed content review.
Required materials and conditions: Report-specific summary, abstract, full-text, registration and plan status
Materials to obtain first: Actual acquisition or review requires separate identity, access and reading-level records. A URL alone does not establish reading, successful access or completed content review.
Further research: Material needed: Actual acquisition or review requires separate identity, access and reading-level records. A URL alone does not establish reading, successful access or completed content review. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Report-specific summary, abstract, full-text, registration and plan status must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Report-specific summary, abstract, full-text, registration and plan status is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N26 · Are adverse-event collection, denominators and exposure known?

Current findings: Parent safety cautions are preserved unchanged. April lists adverse events, but arm-specific event counts, collection methods, denominators and exposure quantities are unverified. Missing numbers are not converted into safety or absence of events.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Active collection, events versus affected people, severity, onset, exposure, arm-specific denominators, discontinuation, rescue and causality-assessment material are needed.
Required materials and conditions: Harm events, collection, severity, exposure and discontinuation
Materials to obtain first: Active collection, events versus affected people, severity, onset, exposure, arm-specific denominators, discontinuation, rescue and causality-assessment material are needed.
Further research: Material needed: Active collection, events versus affected people, severity, onset, exposure, arm-specific denominators, discontinuation, rescue and causality-assessment material are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Harm events, collection, severity, exposure and discontinuation must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Harm events, collection, severity, exposure and discontinuation is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N27 · Can repeated or long-term exposure and vulnerable groups be assessed?

Current findings: The principal 10-minute and separate 30-minute results are not extended into safety verification for long-term or repeated exposure, pregnancy or respiratory vulnerability. Parent cautions are not turned into new procedure guidance.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Long-term and repeated exposure, vulnerable-group eligibility, arm-specific harm follow-up, denominators and actual exposure material are needed.
Required materials and conditions: Brief observation versus long-term, rare harms and vulnerable populations
Materials to obtain first: Long-term and repeated exposure, vulnerable-group eligibility, arm-specific harm follow-up, denominators and actual exposure material are needed.
Further research: Material needed: Long-term and repeated exposure, vulnerable-group eligibility, arm-specific harm follow-up, denominators and actual exposure material are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Brief observation versus long-term, rare harms and vulnerable populations must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Brief observation versus long-term, rare harms and vulnerable populations is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N28 · How do selected C, separate D and parent C54 differ?

Current findings: Acute nausea is C and actual vomiting or cause treatment is D. Individual scores, status and axes are absent; parent C54, Caution and B/P/R1/I2/E+/B2/CX belong to the overall context.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Subclaim and parent records and application boundaries must be distinguished. Parent values do not overwrite subclaim D or create new scores, harm grades or independence certification.
Required materials and conditions: Selected and separate subclaim grades versus parent score, status and axes
Materials to obtain first: Subclaim and parent records and application boundaries must be distinguished. Parent values do not overwrite subclaim D or create new scores, harm grades or independence certification.
Further research: Material needed: Subclaim and parent records and application boundaries must be distinguished. Parent values do not overwrite subclaim D or create new scores, harm grades or independence certification. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Selected and separate subclaim grades versus parent score, status and axes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Selected and separate subclaim grades versus parent score, status and axes is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N29 · Are historical draft B and final C a new reassessment?

Current findings: The parent's draft B, final C, 54 points and cross-check record are historical. The grade was not reassessed in this production.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: A requested verdict change requires preservation of complete originals, events, versions and reasons. This work retains original values.
Required materials and conditions: Original grade-decision history versus current production
Materials to obtain first: A requested verdict change requires preservation of complete originals, events, versions and reasons. This work retains original values.
Further research: Material needed: A requested verdict change requires preservation of complete originals, events, versions and reasons. This work retains original values. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Original grade-decision history versus current production must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Original grade-decision history versus current production is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04

N30 · Were original dates, corrections and production times separated?

Current findings: The original date is 2026-09-07, corrections are an empty array and deliberation an empty string. The current production time does not become an evidence-verification date, and no absent correction is invented.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Material additions, condition revisions, observation application and verdict changes must remain separate events, preserving previous originals.
Required materials and conditions: Historical evidence date, empty corrections and deliberation versus new changes
Materials to obtain first: Material additions, condition revisions, observation application and verdict changes must remain separate events, preserving previous originals.
Further research: Material needed: Material additions, condition revisions, observation application and verdict changes must remain separate events, preserving previous originals. This records needed materials; no new research was executed.
Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.
Conditions for verification: Original material on Historical evidence date, empty corrections and deliberation versus new changes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.
Why this condition is needed: Material on Historical evidence date, empty corrections and deliberation versus new changes is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.
Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02 R03 R04