# Isopropyl-alcohol pad × Acute ED nausea—subjective symptoms at 10 minutes Verdict 3012 · Evidence Check Stored-material review date: Not recorded Original evidence cut-off: 2026-09-07 Review-criteria version: 1.0 Public page/material preparation date: 2026-10-20 Clinical papers were not read directly; existing review summaries were checked. No new clinical-literature search was performed. Unverified does not mean that research is absent or that there is no effect. ## Assessment scope - Population: The question concerns acute nausea in emergency-department adults. Causes, detailed eligibility, baseline severity and valid endpoint-specific denominators remain unverified. Findings are not extended to other populations or settings. - Ingredient, formulation and route: The original intervention is brief inhalation from a 70% isopropyl-alcohol pad. The recorded route is retained and distinguished from ingestion or broad skin application. - Dose: 70% is the original concentration. Actual inhaled quantity, frequency and quantitative exposure remain unverified; concentration is not converted into a dose, and no new procedure or administration guidance is created. - Comparator: Saline-odor control is central, while the separate 3-arm comparison, ondansetron combinations and rescue medication are distinguished. - Measured outcome: The selected endpoint is 10-minute nausea NRS. Satisfaction, rescue use, actual vomiting and cause treatment are distinguished; separate 30-minute within-group VAS findings are not turned into the same between-group effect. - Duration: The principal 10-minute endpoint, measurements at 2 and 4 minutes and the separate 30-minute comparison are distinguished. Persistence, recurrence and repeated-exposure effects after discharge remain unverified. - Questions outside this scope: Extending 10-minute subjective nausea to reduced actual vomiting, cause treatment or less clinical care or fluids; Creating new between-group effects, CIs or NRS conversions from 30-minute within-group VAS; Converting reported null findings into precise absence of effect, equivalence or safety certification; Adding original trials, reviews, shared reports and sheets as unique trials, participants or independent replications; Inheriting registration numbers, historical cross-checks, prespecified MCID or review certainty as current external review or official certification; Creating new procedures, administration or individual-care guidance from original concentration, route or safety cautions ## Checklist items ### N01 · Which acute-nausea question is addressed? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The selected question is relief of acute nausea within 10 minutes, graded C. The positive registered trial and its small, ultra-short subjective endpoint are retained together. Actual vomiting and cause treatment are separate questions. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Original direct comparisons, arm-specific denominators, target effects, CIs and selected versus parent boundaries are needed. No new question, independence certification or subclaim score is created. - Required materials and conditions: Selected 10-minute nausea question, original grade and note versus separate vomiting - Materials to obtain first: Original direct comparisons, arm-specific denominators, target effects, CIs and selected versus parent boundaries are needed. No new question, independence certification or subclaim score is created. - Further research: Material needed: Original direct comparisons, arm-specific denominators, target effects, CIs and selected versus parent boundaries are needed. No new question, independence certification or subclaim score is created. This records needed materials; no new research was executed. - Conditions for verification: Original material on Selected 10-minute nausea question, original grade and note versus separate vomiting must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Selected 10-minute nausea question, original grade and note versus separate vomiting is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03 ### N02 · What is Beadle's direct 10-minute result? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The original 10-minute medians are 3 with alcohol versus 6 with saline, a difference of 3 (95% CI 2 to 4). These are reported values, not a new effect calculated by subtracting arm values. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Scale range, direction, baseline, estimation methods, the effect targeted by the CI and arm-specific analysis denominators are needed. Findings are not transferred to other times or scales. - Required materials and conditions: Original 10-minute NRS findings, difference, CI and comparison - Materials to obtain first: Scale range, direction, baseline, estimation methods, the effect targeted by the CI and arm-specific analysis denominators are needed. Findings are not transferred to other times or scales. - Further research: Material needed: Scale range, direction, baseline, estimation methods, the effect targeted by the CI and arm-specific analysis denominators are needed. Findings are not transferred to other times or scales. This records needed materials; no new research was executed. - Conditions for verification: Original material on Original 10-minute NRS findings, difference, CI and comparison must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Original 10-minute NRS findings, difference, CI and comparison is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01 ### N03 · Do recruitment, completion and arm counts share an analysis denominator? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The record retains 84 recruited, 80 completed, 37 alcohol and 43 saline. Analysis wording in the Korean original and completion wording in the English original are distinguished without further establishing endpoint-specific analysis stages. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Original flow, analysis populations, nausea, satisfaction and rescue denominators and missing-data handling are needed. No new attrition or event count is calculated from differences. - Required materials and conditions: Beadle recruitment, completion, analysis and arm counts - Materials to obtain first: Original flow, analysis populations, nausea, satisfaction and rescue denominators and missing-data handling are needed. No new attrition or event count is calculated from differences. - Further research: Material needed: Original flow, analysis populations, nausea, satisfaction and rescue denominators and missing-data handling are needed. No new attrition or event count is calculated from differences. This records needed materials; no new research was executed. - Conditions for verification: Original material on Beadle recruitment, completion, analysis and arm counts must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Beadle recruitment, completion, analysis and arm counts is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01 ### N04 · Is MCID 1.5 the same as an externally validated important difference? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: April records MCID 1.5, MD -2.18/10 (95% CI -2.76 to -1.60) and moderate certainty. The parent account leaves an externally validated important difference uncertain; these levels are distinguished. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: MCID sources, prespecification, patient-important criteria, measurement tools, effect distributions and responder data are needed. This is not promoted into current official GRADE certification. - Required materials and conditions: Prespecified criteria, review effects and external clinical importance - Materials to obtain first: MCID sources, prespecification, patient-important criteria, measurement tools, effect distributions and responder data are needed. This is not promoted into current official GRADE certification. - Further research: Material needed: MCID sources, prespecification, patient-important criteria, measurement tools, effect distributions and responder data are needed. This is not promoted into current official GRADE certification. This records needed materials; no new research was executed. - Conditions for verification: Original material on Prespecified criteria, review effects and external clinical importance must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Prespecified criteria, review effects and external clinical importance is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R03 ### N05 · Is satisfaction +2 a nausea or vomiting effect? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: Beadle's satisfaction +2 is retained as a reported result. A separate satisfaction scale and CI are unverified; this is not the same value as nausea NRS or cessation of actual vomiting. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Satisfaction tools, timing, denominators, between-group estimates, CIs and prespecified hierarchy are needed. - Required materials and conditions: Satisfaction measures versus nausea NRS and vomiting events - Materials to obtain first: Satisfaction tools, timing, denominators, between-group estimates, CIs and prespecified hierarchy are needed. - Further research: Material needed: Satisfaction tools, timing, denominators, between-group estimates, CIs and prespecified hierarchy are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Satisfaction measures versus nausea NRS and vomiting events must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Satisfaction measures versus nausea NRS and vomiting events is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01 ### N06 · Were rescue-antiemetic findings the same in every trial? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: Beadle records null rescue use, while Candemir records less rescue treatment. Favorable nausea findings do not establish reductions in all trials; rescue need, actual vomiting and cause treatment are distinguished. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Rescue criteria, drugs, exposure, timing, denominators, between-group effects, CIs and concurrent care are needed. - Required materials and conditions: Rescue medication and treatment versus other endpoints - Materials to obtain first: Rescue criteria, drugs, exposure, timing, denominators, between-group effects, CIs and concurrent care are needed. - Further research: Material needed: Rescue criteria, drugs, exposure, timing, denominators, between-group effects, CIs and concurrent care are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Rescue medication and treatment versus other endpoints must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Rescue medication and treatment versus other endpoints is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03 ### N07 · What are Candemir's repeated-time results? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The record retains 118 in ITT, 115 completed, NRS at 2, 4 and 10 minutes, rescue treatment and an overall between-group effect from 2 minutes, P=.008. It is not copied as identical effects, CIs or P values at each time. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Time-specific effects, CIs, denominators, repeated-measures models, multiple comparisons and prespecified hierarchy are needed. - Required materials and conditions: NRS at 2, 4 and 10 minutes and the overall between-group analysis - Materials to obtain first: Time-specific effects, CIs, denominators, repeated-measures models, multiple comparisons and prespecified hierarchy are needed. - Further research: Material needed: Time-specific effects, CIs, denominators, repeated-measures models, multiple comparisons and prespecified hierarchy are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on NRS at 2, 4 and 10 minutes and the overall between-group analysis must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on NRS at 2, 4 and 10 minutes and the overall between-group analysis is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R02 ### N08 · Are 10-minute NRS and 30-minute within-group VAS the same? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The Korean account's 120-person, 3-arm trial records 30-minute within-group VAS reductions of 30mm with alcohol, 32mm with ondansetron plus alcohol and 9mm with ondansetron plus saline. This is distinguished from the 10-minute saline-controlled between-group NRS effect. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Original 3-arm material, arm-specific allocation and analysis, interventions, concurrent drugs, timing, between-group VAS effects, CIs and prespecified plans are needed. No scale conversion or new between-group CI is created. - Required materials and conditions: NCT02760069's separate 3-arm, 30-minute comparison - Materials to obtain first: Original 3-arm material, arm-specific allocation and analysis, interventions, concurrent drugs, timing, between-group VAS effects, CIs and prespecified plans are needed. No scale conversion or new between-group CI is created. - Further research: Material needed: Original 3-arm material, arm-specific allocation and analysis, interventions, concurrent drugs, timing, between-group VAS effects, CIs and prespecified plans are needed. No scale conversion or new between-group CI is created. This records needed materials; no new research was executed. - Conditions for verification: Original material on NCT02760069's separate 3-arm, 30-minute comparison must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on NCT02760069's separate 3-arm, 30-minute comparison is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R04 ### N09 · What do the review's 2 RCTs and 195 participants represent? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The original record retains 2 saline-controlled RCTs, 195 participants and a 10-minute MD of -2.18/10. Trial samples are not newly summed to certify this total, and the review is not added as a new independent RCT. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Included-trial identities, time- and scale-specific extraction denominators, overlap, meta-analysis methods, bias and certainty materials are needed. - Required materials and conditions: April synthesis, included trials and extraction denominators - Materials to obtain first: Included-trial identities, time- and scale-specific extraction denominators, overlap, meta-analysis methods, bias and certainty materials are needed. - Further research: Material needed: Included-trial identities, time- and scale-specific extraction denominators, overlap, meta-analysis methods, bias and certainty materials are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on April synthesis, included trials and extraction denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on April synthesis, included trials and extraction denominators is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03 ### N10 · Were within-group changes distinguished from direct between-group results? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: Beadle's difference and CI and Candemir's overall between-group P value are distinguished as direct comparisons. The separate 120-person, 3-arm, 30-minute values are within-group changes and are not merged into the same effect. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Baseline adjustment, change and endpoint comparisons, models and original between-group estimates and CIs are needed. No new between-group effect is calculated by subtracting within-group values. - Required materials and conditions: Study-specific target effects and analysis levels - Materials to obtain first: Baseline adjustment, change and endpoint comparisons, models and original between-group estimates and CIs are needed. No new between-group effect is calculated by subtracting within-group values. - Further research: Material needed: Baseline adjustment, change and endpoint comparisons, models and original between-group estimates and CIs are needed. No new between-group effect is calculated by subtracting within-group values. This records needed materials; no new research was executed. - Conditions for verification: Original material on Study-specific target effects and analysis levels must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Study-specific target effects and analysis levels is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R04 ### N11 · Were registration and subjective-endpoint limitations retained together? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The original note retains positive registered findings alongside small samples, a 10-minute subjective scale and blinding limitations. A registration number does not resolve all bias. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Original registration, changes, prespecified endpoints, analyses, allocation, measurement and missing-data material are needed. Selected C is not promoted into a new grade. - Required materials and conditions: Original prespecification narrative, small samples and ultra-short measurement - Materials to obtain first: Original registration, changes, prespecified endpoints, analyses, allocation, measurement and missing-data material are needed. Selected C is not promoted into a new grade. - Further research: Material needed: Original registration, changes, prespecified endpoints, analyses, allocation, measurement and missing-data material are needed. Selected C is not promoted into a new grade. This records needed materials; no new research was executed. - Conditions for verification: Original material on Original prespecification narrative, small samples and ultra-short measurement must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Original prespecification narrative, small samples and ultra-short measurement is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03 ### N12 · Does a brief nausea-score result establish less actual vomiting? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The parent states that nausea over minutes does not mean vomiting stops. Its account of null vomiting in one supporting trial is retained; trial identity and event counts remain unverified. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Vomiting definitions, report identity, events versus people, timing, denominators, between-group effects and CIs are needed. Nausea effects are not converted into reduced vomiting. - Required materials and conditions: Subjective nausea versus separate vomiting-event evidence - Materials to obtain first: Vomiting definitions, report identity, events versus people, timing, denominators, between-group effects and CIs are needed. Nausea effects are not converted into reduced vomiting. - Further research: Material needed: Vomiting definitions, report identity, events versus people, timing, denominators, between-group effects and CIs are needed. Nausea effects are not converted into reduced vomiting. This records needed materials; no new research was executed. - Conditions for verification: Original material on Subjective nausea versus separate vomiting-event evidence must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Subjective nausea versus separate vomiting-event evidence is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N13 · Does 10-minute relief establish cause treatment or less clinical care? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The parent distinguishes brief nausea relief while awaiting assessment from reduced underlying diagnosis, treatment or fluid needs. Its original statement that the latter are not demonstrated is retained. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Direct studies and denominators for cause-specific diagnosis, treatment, care, fluids and important clinical outcomes are needed. No new administration, procedure or care guidance is created. - Required materials and conditions: Underlying diagnosis, treatment, fluids and concurrent care boundaries - Materials to obtain first: Direct studies and denominators for cause-specific diagnosis, treatment, care, fluids and important clinical outcomes are needed. No new administration, procedure or care guidance is created. - Further research: Material needed: Direct studies and denominators for cause-specific diagnosis, treatment, care, fluids and important clinical outcomes are needed. No new administration, procedure or care guidance is created. This records needed materials; no new research was executed. - Conditions for verification: Original material on Underlying diagnosis, treatment, fluids and concurrent care boundaries must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Underlying diagnosis, treatment, fluids and concurrent care boundaries is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N14 · Do short-term findings establish durability or recurrence effects? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The principal endpoint is 10 minutes, with a separate 30-minute result. Persistence, recurrence and repeated-exposure effects after discharge are not established, and short-term material is not labeled long-term. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Longer follow-up, recurrence, rescue, cause treatment, concurrent care and corresponding analysis denominators are needed. - Required materials and conditions: A 10-minute endpoint versus long-term and recurrent nausea - Materials to obtain first: Longer follow-up, recurrence, rescue, cause treatment, concurrent care and corresponding analysis denominators are needed. - Further research: Material needed: Longer follow-up, recurrence, rescue, cause treatment, concurrent care and corresponding analysis denominators are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on A 10-minute endpoint versus long-term and recurrent nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on A 10-minute endpoint versus long-term and recurrent nausea is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N15 · Which emergency-department adults were studied? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The parent scope concerns acute nausea in emergency-department adults. Recruitment, completion and arm counts from the representative trial do not replace full causes or eligibility criteria. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. Findings are not extended to other populations or settings. - Required materials and conditions: Eligibility, causes and baseline severity in acute nausea - Materials to obtain first: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. Findings are not extended to other populations or settings. - Further research: Material needed: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. Findings are not extended to other populations or settings. This records needed materials; no new research was executed. - Conditions for verification: Original material on Eligibility, causes and baseline severity in acute nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Eligibility, causes and baseline severity in acute nausea is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N16 · What are the formulation and route boundaries for the 70% pad? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The original intervention is brief inhalation from a 70% isopropyl-alcohol pad. Concentration is not converted into inhaled quantity, frequency or exposure; ingestion and broad skin application are distinguished. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Original products, manufacturing, pad volume, exposure criteria and comparability between arms are needed. No new procedure or administration method is created. - Required materials and conditions: Original formulation, concentration, exposure and intervention boundaries - Materials to obtain first: Original products, manufacturing, pad volume, exposure criteria and comparability between arms are needed. No new procedure or administration method is created. - Further research: Material needed: Original products, manufacturing, pad volume, exposure criteria and comparability between arms are needed. No new procedure or administration method is created. This records needed materials; no new research was executed. - Conditions for verification: Original material on Original formulation, concentration, exposure and intervention boundaries must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Original formulation, concentration, exposure and intervention boundaries is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N17 · Are saline-odor control and drug comparisons the same? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: Beadle's saline-odor control is distinguished from NCT02760069's 120-person, 3-arm comparison involving ondansetron. Controls and results are not treated as the same effect. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Arm-specific interventions, concurrent antiemetics, allocation, rescue criteria, target effects and original between-group results are needed. - Required materials and conditions: Controls, concurrent drugs, rescue medication and target effects - Materials to obtain first: Arm-specific interventions, concurrent antiemetics, allocation, rescue criteria, target effects and original between-group results are needed. - Further research: Material needed: Arm-specific interventions, concurrent antiemetics, allocation, rescue criteria, target effects and original between-group results are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Controls, concurrent drugs, rescue medication and target effects must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Controls, concurrent drugs, rescue medication and target effects is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N18 · Were recruitment, completion, ITT and endpoint denominators distinguished? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: Beadle's 84 recruited, 80 completed, 37 alcohol and 43 saline, and Candemir's 118 in ITT and 115 completed are retained. A separate 120-person, 3-arm trial and the review's 195 participants are different contexts. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Recruitment, allocation, completion, time-specific assessments, analysis, arm-specific missingness and ITT definitions are needed. No new differences or participant totals are calculated. - Required materials and conditions: Trial flow and valid arm- and endpoint-specific denominators - Materials to obtain first: Recruitment, allocation, completion, time-specific assessments, analysis, arm-specific missingness and ITT definitions are needed. No new differences or participant totals are calculated. - Further research: Material needed: Recruitment, allocation, completion, time-specific assessments, analysis, arm-specific missingness and ITT definitions are needed. No new differences or participant totals are calculated. This records needed materials; no new research was executed. - Conditions for verification: Original material on Trial flow and valid arm- and endpoint-specific denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Trial flow and valid arm- and endpoint-specific denominators is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N19 · What are odor-related blinding limitations? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The account and bibliography retain incomplete blinding due to odor. The randomized-trial label does not establish adequate subjective assessment and blinding throughout. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Allocation, concealment, people blinded, blinding success, NRS collectors, procedures, losses and revealing cues are needed. No new official RoB2 judgment is made. - Required materials and conditions: Allocation, concealment, subjective-score collection and expectations - Materials to obtain first: Allocation, concealment, people blinded, blinding success, NRS collectors, procedures, losses and revealing cues are needed. No new official RoB2 judgment is made. - Further research: Material needed: Allocation, concealment, people blinded, blinding success, NRS collectors, procedures, losses and revealing cues are needed. No new official RoB2 judgment is made. This records needed materials; no new research was executed. - Conditions for verification: Original material on Allocation, concealment, subjective-score collection and expectations must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Allocation, concealment, subjective-score collection and expectations is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N20 · Does a registration number mean external registration was read? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: NCT02092441 appears in original evidence and bibliography, and NCT02760069 in the Korean account. Candemir's original registration is unverified. CRD42022299815 identifies April's review; external registration and plans were unread here. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Each trial's and review's original registration, changes, protocol, analysis plans, prespecified endpoints and denominators must be distinguished. Numbers alone do not establish verified prespecification or identity. - Required materials and conditions: Trial registration, review registration and prespecification material - Materials to obtain first: Each trial's and review's original registration, changes, protocol, analysis plans, prespecified endpoints and denominators must be distinguished. Numbers alone do not establish verified prespecification or identity. - Further research: Material needed: Each trial's and review's original registration, changes, protocol, analysis plans, prespecified endpoints and denominators must be distinguished. Numbers alone do not establish verified prespecification or identity. This records needed materials; no new research was executed. - Conditions for verification: Original material on Trial registration, review registration and prespecification material must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Trial registration, review registration and prespecification material is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N21 · Were different company-involvement items distinguished? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: Beadle is reported as a military institutional study without manufacturer sponsorship; Candemir reports no COI with specific funding unverified; April reports academic research without manufacturer involvement. Detailed funding for the separate combined-drug comparison is unverified. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Original documents on financial and product support, company affiliations, design, analysis and publication roles are needed separately. One item does not establish absence of every form of involvement. - Required materials and conditions: Funding, product support, affiliations, analysis and publication roles - Materials to obtain first: Original documents on financial and product support, company affiliations, design, analysis and publication roles are needed separately. One item does not establish absence of every form of involvement. - Further research: Material needed: Original documents on financial and product support, company affiliations, design, analysis and publication roles are needed separately. One item does not establish absence of every form of involvement. This records needed materials; no new research was executed. - Conditions for verification: Original material on Funding, product support, affiliations, analysis and publication roles must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Funding, product support, affiliations, analysis and publication roles is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N22 · Were reports, reviews and subquestions double-counted? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: Both subquestions share the parent's Beadle, Candemir and April reports and separate Korean comparison context. The review synthesizes included trials, and the Korean 120-person description is not a separate evidence or bibliography entry. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Included trials, time-specific analysis populations, reports and cohort identity tables are needed. Report slots, sheets and samples are not added as unique trials, participants or independent replications. - Required materials and conditions: Reports, original trials, cohorts and shared relationships - Materials to obtain first: Included trials, time-specific analysis populations, reports and cohort identity tables are needed. Report slots, sheets and samples are not added as unique trials, participants or independent replications. - Further research: Material needed: Included trials, time-specific analysis populations, reports and cohort identity tables are needed. Report slots, sheets and samples are not added as unique trials, participants or independent replications. This records needed materials; no new research was executed. - Conditions for verification: Original material on Reports, original trials, cohorts and shared relationships must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Reports, original trials, cohorts and shared relationships is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N23 · What is the level of the original independent-replication wording? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The parent's independent-replication wording and unverified funding, registration and prespecification are retained together. They are not promoted into current independence certification or a confirmed unique-trial total. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Original registration, plans, institutions, recruitment, support and overlapping-report relationships are needed. Uncertain unique totals remain uncertain. - Required materials and conditions: Candemir support versus funding and prespecification gaps - Materials to obtain first: Original registration, plans, institutions, recruitment, support and overlapping-report relationships are needed. Uncertain unique totals remain uncertain. - Further research: Material needed: Original registration, plans, institutions, recruitment, support and overlapping-report relationships are needed. Uncertain unique totals remain uncertain. This records needed materials; no new research was executed. - Conditions for verification: Original material on Candemir support versus funding and prespecification gaps must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Candemir support versus funding and prespecification gaps is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03 ### N24 · Were differing parent Korean and English contexts retained? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The Korean account contains NCT02760069's 30-minute within-group VAS; the English account contains a 10-minute meta-analysis of two placebo-controlled trials and 195 participants. They are not substituted for each other as translations of the same report, time or effect. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Original trial and review result tables, denominators, times and effect comparisons are needed. Complete parent Korean and English accounts are preserved without new external comparison or correction. - Required materials and conditions: Korean 30-minute, 3-arm findings versus English synthesis - Materials to obtain first: Original trial and review result tables, denominators, times and effect comparisons are needed. Complete parent Korean and English accounts are preserved without new external comparison or correction. - Further research: Material needed: Original trial and review result tables, denominators, times and effect comparisons are needed. Complete parent Korean and English accounts are preserved without new external comparison or correction. This records needed materials; no new research was executed. - Conditions for verification: Original material on Korean 30-minute, 3-arm findings versus English synthesis must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Korean 30-minute, 3-arm findings versus English synthesis is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N25 · Does stored-summary reading equal external-original reading? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The complete stored parent summary was read. Historical verification and cross-check narratives are distinguished from actual reading here; external abstracts, full text, registration and plans remain unread. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Actual acquisition or review requires separate identity, access and reading-level records. A URL alone does not establish reading, successful access or completed content review. - Required materials and conditions: Report-specific summary, abstract, full-text, registration and plan status - Materials to obtain first: Actual acquisition or review requires separate identity, access and reading-level records. A URL alone does not establish reading, successful access or completed content review. - Further research: Material needed: Actual acquisition or review requires separate identity, access and reading-level records. A URL alone does not establish reading, successful access or completed content review. This records needed materials; no new research was executed. - Conditions for verification: Original material on Report-specific summary, abstract, full-text, registration and plan status must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Report-specific summary, abstract, full-text, registration and plan status is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N26 · Are adverse-event collection, denominators and exposure known? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: Parent safety cautions are preserved unchanged. April lists adverse events, but arm-specific event counts, collection methods, denominators and exposure quantities are unverified. Missing numbers are not converted into safety or absence of events. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Active collection, events versus affected people, severity, onset, exposure, arm-specific denominators, discontinuation, rescue and causality-assessment material are needed. - Required materials and conditions: Harm events, collection, severity, exposure and discontinuation - Materials to obtain first: Active collection, events versus affected people, severity, onset, exposure, arm-specific denominators, discontinuation, rescue and causality-assessment material are needed. - Further research: Material needed: Active collection, events versus affected people, severity, onset, exposure, arm-specific denominators, discontinuation, rescue and causality-assessment material are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Harm events, collection, severity, exposure and discontinuation must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Harm events, collection, severity, exposure and discontinuation is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N27 · Can repeated or long-term exposure and vulnerable groups be assessed? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The principal 10-minute and separate 30-minute results are not extended into safety verification for long-term or repeated exposure, pregnancy or respiratory vulnerability. Parent cautions are not turned into new procedure guidance. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Long-term and repeated exposure, vulnerable-group eligibility, arm-specific harm follow-up, denominators and actual exposure material are needed. - Required materials and conditions: Brief observation versus long-term, rare harms and vulnerable populations - Materials to obtain first: Long-term and repeated exposure, vulnerable-group eligibility, arm-specific harm follow-up, denominators and actual exposure material are needed. - Further research: Material needed: Long-term and repeated exposure, vulnerable-group eligibility, arm-specific harm follow-up, denominators and actual exposure material are needed. This records needed materials; no new research was executed. - Conditions for verification: Original material on Brief observation versus long-term, rare harms and vulnerable populations must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Brief observation versus long-term, rare harms and vulnerable populations is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N28 · How do selected C, separate D and parent C54 differ? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: Acute nausea is C and actual vomiting or cause treatment is D. Individual scores, status and axes are absent; parent C54, Caution and B/P/R1/I2/E+/B2/CX belong to the overall context. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Subclaim and parent records and application boundaries must be distinguished. Parent values do not overwrite subclaim D or create new scores, harm grades or independence certification. - Required materials and conditions: Selected and separate subclaim grades versus parent score, status and axes - Materials to obtain first: Subclaim and parent records and application boundaries must be distinguished. Parent values do not overwrite subclaim D or create new scores, harm grades or independence certification. - Further research: Material needed: Subclaim and parent records and application boundaries must be distinguished. Parent values do not overwrite subclaim D or create new scores, harm grades or independence certification. This records needed materials; no new research was executed. - Conditions for verification: Original material on Selected and separate subclaim grades versus parent score, status and axes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Selected and separate subclaim grades versus parent score, status and axes is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N29 · Are historical draft B and final C a new reassessment? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The parent's draft B, final C, 54 points and cross-check record are historical. The grade was not reassessed in this production. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: A requested verdict change requires preservation of complete originals, events, versions and reasons. This work retains original values. - Required materials and conditions: Original grade-decision history versus current production - Materials to obtain first: A requested verdict change requires preservation of complete originals, events, versions and reasons. This work retains original values. - Further research: Material needed: A requested verdict change requires preservation of complete originals, events, versions and reasons. This work retains original values. This records needed materials; no new research was executed. - Conditions for verification: Original material on Original grade-decision history versus current production must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Original grade-decision history versus current production is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ### N30 · Were original dates, corrections and production times separated? Verification status: Partly verified Reading scope: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread - Current findings: The original date is 2026-09-07, corrections are an empty array and deliberation an empty string. The current production time does not become an evidence-verification date, and no absent correction is invented. - Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence. - Reason for missing information: Material additions, condition revisions, observation application and verdict changes must remain separate events, preserving previous originals. - Required materials and conditions: Historical evidence date, empty corrections and deliberation versus new changes - Materials to obtain first: Material additions, condition revisions, observation application and verdict changes must remain separate events, preserving previous originals. - Further research: Material needed: Material additions, condition revisions, observation application and verdict changes must remain separate events, preserving previous originals. This records needed materials; no new research was executed. - Conditions for verification: Original material on Historical evidence date, empty corrections and deliberation versus new changes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material. - Why this condition is needed: Material on Historical evidence date, empty corrections and deliberation versus new changes is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries. - Application exceptions: Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created. - Remaining uncertainty: Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification. - Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production. - Related sources: R01, R02, R03, R04 ## Evidence and sources ### R01 Beadle KL et al. 2016 [PubMed](https://pubmed.ncbi.nlm.nih.gov/26679977/) Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread. Findings recorded in the summary: The record states 84 recruited, 80 completed, 37 alcohol and 43 saline. Original 10-minute medians of 3 versus 6, difference 3 (95% CI 2 to 4), satisfaction +2 and null rescue use are retained. Record level: This is a stored summary of direct NRS findings. Recruitment, completion, analysis wording and endpoint-specific denominators are distinguished; historical registration and verification narratives are not promoted into current external verification. Independent replication: Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Protocol and analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | ### R02 Candemir H et al. 2021 [PubMed](https://pubmed.ncbi.nlm.nih.gov/33373914/) Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread. Findings recorded in the summary: The report records 118 in ITT, 115 completed, nausea NRS at 2, 4 and 10 minutes and rescue treatment. The overall between-group effect from 2 minutes, P=.008, and less rescue treatment are retained without copying identical effects or CIs to each time. Record level: Original independent-replication wording is retained together with unverified specific funding, registration and prespecification. No current independence certification or confirmed unique-trial total is created. Independent replication: Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Protocol and analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | ### R03 April MD et al. 2023 [PubMed](https://pubmed.ncbi.nlm.nih.gov/37076258/) Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread. Findings recorded in the summary: The original record retains 2 saline-controlled RCTs, 195 participants, 10-minute MD -2.18/10 (95% CI -2.76 to -1.60), MCID 1.5 and moderate certainty. Record level: These are the original review's criteria and certainty narratives. Externally validated important differences, extraction from included trials and overlap remain unverified; the review is not counted as a new original trial or current official GRADE assessment. Independent replication: Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Protocol and analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | ### R04 Separate 3-arm summary in the stored Korean account Materials actually read: Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread. Findings recorded in the summary: The 120-person, 3-arm, 30-minute within-group VAS reductions are 30mm with alcohol, 32mm with ondansetron plus alcohol and 9mm with ondansetron plus saline. This remains separate Korean context without new between-group effects, CIs or NRS conversion. Record level: This is preserved context from the parent Korean explanation. Detailed bibliography, an original-text URL, arm-specific analysis denominators and original between-group results are unlinked; no external link is newly inferred. Independent replication: Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | | Protocol and analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review. | ## Review criteria and methods These are Chamgap's own application conditions, informed by the relevant sections of official methodological guidance. They do not constitute official assessment-tool certification or a new efficacy score. - M03 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03) · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13 · Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M04 [Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04) · §4.5, §4.6.1–4.6.3, MECIR C42 · Distinguish studies from reports and link them; do not omit a study solely because results are unreported. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M08 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08) · §8.1–8.2.3, Table 8.2.a · Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M15 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15) · §15.2.4, §15.3.1–15.3.3 · Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M19 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19) · §19.1.2, §19.2.1–19.2.4 · Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. ## What the statuses mean - Partly verified: Partial information from the stored summary is linked; detailed originals and content review remain incomplete. - Unverified: Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety. - Review incomplete: Review of existing content remains incomplete. - Met: This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work. - Not reported: Unreported within material actually read. Unread external material is not relabeled as unreported. - Inaccessible: This means actual access failure. External access was not attempted in this work, so this state was not assigned. - Not applicable: Used only with an application exception and reason based on the question scope. - Conflicting data: This requires actual comparison of materials; no new conflict judgment was made in this work. - Insufficient evidence for the conditions: This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade. ## Change history 2026-10-20 · Public page/materials 1.0. Public-facing views and materials were prepared from the existing 30 items. No new clinical search, verification-status change or scoring was performed.