{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v3012-s0",
  "verdict_number": "3012",
  "title": "Isopropyl-alcohol pad × Acute ED nausea—subjective symptoms at 10 minutes",
  "view_version": "1.0",
  "view_created_date": "2026-10-20",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-09-07",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "The question concerns acute nausea in emergency-department adults. Causes, detailed eligibility, baseline severity and valid endpoint-specific denominators remain unverified. Findings are not extended to other populations or settings.",
    "intervention": "The original intervention is brief inhalation from a 70% isopropyl-alcohol pad. The recorded route is retained and distinguished from ingestion or broad skin application.",
    "dose": "70% is the original concentration. Actual inhaled quantity, frequency and quantitative exposure remain unverified; concentration is not converted into a dose, and no new procedure or administration guidance is created.",
    "comparator": "Saline-odor control is central, while the separate 3-arm comparison, ondansetron combinations and rescue medication are distinguished.",
    "endpoint": "The selected endpoint is 10-minute nausea NRS. Satisfaction, rescue use, actual vomiting and cause treatment are distinguished; separate 30-minute within-group VAS findings are not turned into the same between-group effect.",
    "duration": "The principal 10-minute endpoint, measurements at 2 and 4 minutes and the separate 30-minute comparison are distinguished. Persistence, recurrence and repeated-exposure effects after discharge remain unverified.",
    "excluded_extensions": [
      "Extending 10-minute subjective nausea to reduced actual vomiting, cause treatment or less clinical care or fluids",
      "Creating new between-group effects, CIs or NRS conversions from 30-minute within-group VAS",
      "Converting reported null findings into precise absence of effect, equivalence or safety certification",
      "Adding original trials, reviews, shared reports and sheets as unique trials, participants or independent replications",
      "Inheriting registration numbers, historical cross-checks, prespecified MCID or review certainty as current external review or official certification",
      "Creating new procedures, administration or individual-care guidance from original concentration, route or safety cautions"
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which acute-nausea question is addressed?",
      "needed": "Selected 10-minute nausea question, original grade and note versus separate vomiting",
      "role": "Required",
      "role_reason": "Material on Selected 10-minute nausea question, original grade and note versus separate vomiting is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Selected 10-minute nausea question, original grade and note versus separate vomiting must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original direct comparisons, arm-specific denominators, target effects, CIs and selected versus parent boundaries are needed. No new question, independence certification or subclaim score is created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The selected question is relief of acute nausea within 10 minutes, graded C. The positive registered trial and its small, ultra-short subjective endpoint are retained together. Actual vomiting and cause treatment are separate questions.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original direct comparisons, arm-specific denominators, target effects, CIs and selected versus parent boundaries are needed. No new question, independence certification or subclaim score is created.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original direct comparisons, arm-specific denominators, target effects, CIs and selected versus parent boundaries are needed. No new question, independence certification or subclaim score is created."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "What is Beadle's direct 10-minute result?",
      "needed": "Original 10-minute NRS findings, difference, CI and comparison",
      "role": "Required",
      "role_reason": "Material on Original 10-minute NRS findings, difference, CI and comparison is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Original 10-minute NRS findings, difference, CI and comparison must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Scale range, direction, baseline, estimation methods, the effect targeted by the CI and arm-specific analysis denominators are needed. Findings are not transferred to other times or scales. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The original 10-minute medians are 3 with alcohol versus 6 with saline, a difference of 3 (95% CI 2 to 4). These are reported values, not a new effect calculated by subtracting arm values.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Scale range, direction, baseline, estimation methods, the effect targeted by the CI and arm-specific analysis denominators are needed. Findings are not transferred to other times or scales.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Scale range, direction, baseline, estimation methods, the effect targeted by the CI and arm-specific analysis denominators are needed. Findings are not transferred to other times or scales."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Do recruitment, completion and arm counts share an analysis denominator?",
      "needed": "Beadle recruitment, completion, analysis and arm counts",
      "role": "Required",
      "role_reason": "Material on Beadle recruitment, completion, analysis and arm counts is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Beadle recruitment, completion, analysis and arm counts must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original flow, analysis populations, nausea, satisfaction and rescue denominators and missing-data handling are needed. No new attrition or event count is calculated from differences. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The record retains 84 recruited, 80 completed, 37 alcohol and 43 saline. Analysis wording in the Korean original and completion wording in the English original are distinguished without further establishing endpoint-specific analysis stages.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original flow, analysis populations, nausea, satisfaction and rescue denominators and missing-data handling are needed. No new attrition or event count is calculated from differences.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original flow, analysis populations, nausea, satisfaction and rescue denominators and missing-data handling are needed. No new attrition or event count is calculated from differences."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Is MCID 1.5 the same as an externally validated important difference?",
      "needed": "Prespecified criteria, review effects and external clinical importance",
      "role": "Required",
      "role_reason": "Material on Prespecified criteria, review effects and external clinical importance is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Prespecified criteria, review effects and external clinical importance must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: MCID sources, prespecification, patient-important criteria, measurement tools, effect distributions and responder data are needed. This is not promoted into current official GRADE certification. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R03"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "April records MCID 1.5, MD -2.18/10 (95% CI -2.76 to -1.60) and moderate certainty. The parent account leaves an externally validated important difference uncertain; these levels are distinguished.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "MCID sources, prespecification, patient-important criteria, measurement tools, effect distributions and responder data are needed. This is not promoted into current official GRADE certification.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "MCID sources, prespecification, patient-important criteria, measurement tools, effect distributions and responder data are needed. This is not promoted into current official GRADE certification."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Is satisfaction +2 a nausea or vomiting effect?",
      "needed": "Satisfaction measures versus nausea NRS and vomiting events",
      "role": "Required",
      "role_reason": "Material on Satisfaction measures versus nausea NRS and vomiting events is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Satisfaction measures versus nausea NRS and vomiting events must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Satisfaction tools, timing, denominators, between-group estimates, CIs and prespecified hierarchy are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Beadle's satisfaction +2 is retained as a reported result. A separate satisfaction scale and CI are unverified; this is not the same value as nausea NRS or cessation of actual vomiting.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Satisfaction tools, timing, denominators, between-group estimates, CIs and prespecified hierarchy are needed.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Satisfaction tools, timing, denominators, between-group estimates, CIs and prespecified hierarchy are needed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Were rescue-antiemetic findings the same in every trial?",
      "needed": "Rescue medication and treatment versus other endpoints",
      "role": "Required",
      "role_reason": "Material on Rescue medication and treatment versus other endpoints is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Rescue medication and treatment versus other endpoints must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Rescue criteria, drugs, exposure, timing, denominators, between-group effects, CIs and concurrent care are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Beadle records null rescue use, while Candemir records less rescue treatment. Favorable nausea findings do not establish reductions in all trials; rescue need, actual vomiting and cause treatment are distinguished.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Rescue criteria, drugs, exposure, timing, denominators, between-group effects, CIs and concurrent care are needed.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Rescue criteria, drugs, exposure, timing, denominators, between-group effects, CIs and concurrent care are needed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "What are Candemir's repeated-time results?",
      "needed": "NRS at 2, 4 and 10 minutes and the overall between-group analysis",
      "role": "Required",
      "role_reason": "Material on NRS at 2, 4 and 10 minutes and the overall between-group analysis is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on NRS at 2, 4 and 10 minutes and the overall between-group analysis must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Time-specific effects, CIs, denominators, repeated-measures models, multiple comparisons and prespecified hierarchy are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The record retains 118 in ITT, 115 completed, NRS at 2, 4 and 10 minutes, rescue treatment and an overall between-group effect from 2 minutes, P=.008. It is not copied as identical effects, CIs or P values at each time.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Time-specific effects, CIs, denominators, repeated-measures models, multiple comparisons and prespecified hierarchy are needed.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Time-specific effects, CIs, denominators, repeated-measures models, multiple comparisons and prespecified hierarchy are needed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Are 10-minute NRS and 30-minute within-group VAS the same?",
      "needed": "NCT02760069's separate 3-arm, 30-minute comparison",
      "role": "Required",
      "role_reason": "Material on NCT02760069's separate 3-arm, 30-minute comparison is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on NCT02760069's separate 3-arm, 30-minute comparison must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original 3-arm material, arm-specific allocation and analysis, interventions, concurrent drugs, timing, between-group VAS effects, CIs and prespecified plans are needed. No scale conversion or new between-group CI is created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The Korean account's 120-person, 3-arm trial records 30-minute within-group VAS reductions of 30mm with alcohol, 32mm with ondansetron plus alcohol and 9mm with ondansetron plus saline. This is distinguished from the 10-minute saline-controlled between-group NRS effect.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original 3-arm material, arm-specific allocation and analysis, interventions, concurrent drugs, timing, between-group VAS effects, CIs and prespecified plans are needed. No scale conversion or new between-group CI is created.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original 3-arm material, arm-specific allocation and analysis, interventions, concurrent drugs, timing, between-group VAS effects, CIs and prespecified plans are needed. No scale conversion or new between-group CI is created."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What do the review's 2 RCTs and 195 participants represent?",
      "needed": "April synthesis, included trials and extraction denominators",
      "role": "Required",
      "role_reason": "Material on April synthesis, included trials and extraction denominators is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on April synthesis, included trials and extraction denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Included-trial identities, time- and scale-specific extraction denominators, overlap, meta-analysis methods, bias and certainty materials are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The original record retains 2 saline-controlled RCTs, 195 participants and a 10-minute MD of -2.18/10. Trial samples are not newly summed to certify this total, and the review is not added as a new independent RCT.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Included-trial identities, time- and scale-specific extraction denominators, overlap, meta-analysis methods, bias and certainty materials are needed.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Included-trial identities, time- and scale-specific extraction denominators, overlap, meta-analysis methods, bias and certainty materials are needed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Were within-group changes distinguished from direct between-group results?",
      "needed": "Study-specific target effects and analysis levels",
      "role": "Required",
      "role_reason": "Material on Study-specific target effects and analysis levels is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Study-specific target effects and analysis levels must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Baseline adjustment, change and endpoint comparisons, models and original between-group estimates and CIs are needed. No new between-group effect is calculated by subtracting within-group values. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Beadle's difference and CI and Candemir's overall between-group P value are distinguished as direct comparisons. The separate 120-person, 3-arm, 30-minute values are within-group changes and are not merged into the same effect.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Baseline adjustment, change and endpoint comparisons, models and original between-group estimates and CIs are needed. No new between-group effect is calculated by subtracting within-group values.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Baseline adjustment, change and endpoint comparisons, models and original between-group estimates and CIs are needed. No new between-group effect is calculated by subtracting within-group values."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Were registration and subjective-endpoint limitations retained together?",
      "needed": "Original prespecification narrative, small samples and ultra-short measurement",
      "role": "Required",
      "role_reason": "Material on Original prespecification narrative, small samples and ultra-short measurement is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Original prespecification narrative, small samples and ultra-short measurement must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original registration, changes, prespecified endpoints, analyses, allocation, measurement and missing-data material are needed. Selected C is not promoted into a new grade. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The original note retains positive registered findings alongside small samples, a 10-minute subjective scale and blinding limitations. A registration number does not resolve all bias.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original registration, changes, prespecified endpoints, analyses, allocation, measurement and missing-data material are needed. Selected C is not promoted into a new grade.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original registration, changes, prespecified endpoints, analyses, allocation, measurement and missing-data material are needed. Selected C is not promoted into a new grade."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Does a brief nausea-score result establish less actual vomiting?",
      "needed": "Subjective nausea versus separate vomiting-event evidence",
      "role": "Required",
      "role_reason": "Material on Subjective nausea versus separate vomiting-event evidence is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Subjective nausea versus separate vomiting-event evidence must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Vomiting definitions, report identity, events versus people, timing, denominators, between-group effects and CIs are needed. Nausea effects are not converted into reduced vomiting. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The parent states that nausea over minutes does not mean vomiting stops. Its account of null vomiting in one supporting trial is retained; trial identity and event counts remain unverified.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Vomiting definitions, report identity, events versus people, timing, denominators, between-group effects and CIs are needed. Nausea effects are not converted into reduced vomiting.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Vomiting definitions, report identity, events versus people, timing, denominators, between-group effects and CIs are needed. Nausea effects are not converted into reduced vomiting."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Does 10-minute relief establish cause treatment or less clinical care?",
      "needed": "Underlying diagnosis, treatment, fluids and concurrent care boundaries",
      "role": "Required",
      "role_reason": "Material on Underlying diagnosis, treatment, fluids and concurrent care boundaries is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Underlying diagnosis, treatment, fluids and concurrent care boundaries must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Direct studies and denominators for cause-specific diagnosis, treatment, care, fluids and important clinical outcomes are needed. No new administration, procedure or care guidance is created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The parent distinguishes brief nausea relief while awaiting assessment from reduced underlying diagnosis, treatment or fluid needs. Its original statement that the latter are not demonstrated is retained.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Direct studies and denominators for cause-specific diagnosis, treatment, care, fluids and important clinical outcomes are needed. No new administration, procedure or care guidance is created.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct studies and denominators for cause-specific diagnosis, treatment, care, fluids and important clinical outcomes are needed. No new administration, procedure or care guidance is created."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Do short-term findings establish durability or recurrence effects?",
      "needed": "A 10-minute endpoint versus long-term and recurrent nausea",
      "role": "Required",
      "role_reason": "Material on A 10-minute endpoint versus long-term and recurrent nausea is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on A 10-minute endpoint versus long-term and recurrent nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Longer follow-up, recurrence, rescue, cause treatment, concurrent care and corresponding analysis denominators are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The principal endpoint is 10 minutes, with a separate 30-minute result. Persistence, recurrence and repeated-exposure effects after discharge are not established, and short-term material is not labeled long-term.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Longer follow-up, recurrence, rescue, cause treatment, concurrent care and corresponding analysis denominators are needed.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Longer follow-up, recurrence, rescue, cause treatment, concurrent care and corresponding analysis denominators are needed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Which emergency-department adults were studied?",
      "needed": "Eligibility, causes and baseline severity in acute nausea",
      "role": "Required",
      "role_reason": "Material on Eligibility, causes and baseline severity in acute nausea is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Eligibility, causes and baseline severity in acute nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. Findings are not extended to other populations or settings. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The parent scope concerns acute nausea in emergency-department adults. Recruitment, completion and arm counts from the representative trial do not replace full causes or eligibility criteria.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. Findings are not extended to other populations or settings.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. Findings are not extended to other populations or settings."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "What are the formulation and route boundaries for the 70% pad?",
      "needed": "Original formulation, concentration, exposure and intervention boundaries",
      "role": "Required",
      "role_reason": "Material on Original formulation, concentration, exposure and intervention boundaries is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Original formulation, concentration, exposure and intervention boundaries must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original products, manufacturing, pad volume, exposure criteria and comparability between arms are needed. No new procedure or administration method is created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The original intervention is brief inhalation from a 70% isopropyl-alcohol pad. Concentration is not converted into inhaled quantity, frequency or exposure; ingestion and broad skin application are distinguished.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original products, manufacturing, pad volume, exposure criteria and comparability between arms are needed. No new procedure or administration method is created.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original products, manufacturing, pad volume, exposure criteria and comparability between arms are needed. No new procedure or administration method is created."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Are saline-odor control and drug comparisons the same?",
      "needed": "Controls, concurrent drugs, rescue medication and target effects",
      "role": "Required",
      "role_reason": "Material on Controls, concurrent drugs, rescue medication and target effects is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Controls, concurrent drugs, rescue medication and target effects must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Arm-specific interventions, concurrent antiemetics, allocation, rescue criteria, target effects and original between-group results are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Beadle's saline-odor control is distinguished from NCT02760069's 120-person, 3-arm comparison involving ondansetron. Controls and results are not treated as the same effect.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Arm-specific interventions, concurrent antiemetics, allocation, rescue criteria, target effects and original between-group results are needed.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Arm-specific interventions, concurrent antiemetics, allocation, rescue criteria, target effects and original between-group results are needed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Were recruitment, completion, ITT and endpoint denominators distinguished?",
      "needed": "Trial flow and valid arm- and endpoint-specific denominators",
      "role": "Required",
      "role_reason": "Material on Trial flow and valid arm- and endpoint-specific denominators is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Trial flow and valid arm- and endpoint-specific denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Recruitment, allocation, completion, time-specific assessments, analysis, arm-specific missingness and ITT definitions are needed. No new differences or participant totals are calculated. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Beadle's 84 recruited, 80 completed, 37 alcohol and 43 saline, and Candemir's 118 in ITT and 115 completed are retained. A separate 120-person, 3-arm trial and the review's 195 participants are different contexts.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Recruitment, allocation, completion, time-specific assessments, analysis, arm-specific missingness and ITT definitions are needed. No new differences or participant totals are calculated.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Recruitment, allocation, completion, time-specific assessments, analysis, arm-specific missingness and ITT definitions are needed. No new differences or participant totals are calculated."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "What are odor-related blinding limitations?",
      "needed": "Allocation, concealment, subjective-score collection and expectations",
      "role": "Required",
      "role_reason": "Material on Allocation, concealment, subjective-score collection and expectations is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Allocation, concealment, subjective-score collection and expectations must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Allocation, concealment, people blinded, blinding success, NRS collectors, procedures, losses and revealing cues are needed. No new official RoB2 judgment is made. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The account and bibliography retain incomplete blinding due to odor. The randomized-trial label does not establish adequate subjective assessment and blinding throughout.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Allocation, concealment, people blinded, blinding success, NRS collectors, procedures, losses and revealing cues are needed. No new official RoB2 judgment is made.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Allocation, concealment, people blinded, blinding success, NRS collectors, procedures, losses and revealing cues are needed. No new official RoB2 judgment is made."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Does a registration number mean external registration was read?",
      "needed": "Trial registration, review registration and prespecification material",
      "role": "Required",
      "role_reason": "Material on Trial registration, review registration and prespecification material is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Trial registration, review registration and prespecification material must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Each trial's and review's original registration, changes, protocol, analysis plans, prespecified endpoints and denominators must be distinguished. Numbers alone do not establish verified prespecification or identity. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "NCT02092441 appears in original evidence and bibliography, and NCT02760069 in the Korean account. Candemir's original registration is unverified. CRD42022299815 identifies April's review; external registration and plans were unread here.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Each trial's and review's original registration, changes, protocol, analysis plans, prespecified endpoints and denominators must be distinguished. Numbers alone do not establish verified prespecification or identity.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Each trial's and review's original registration, changes, protocol, analysis plans, prespecified endpoints and denominators must be distinguished. Numbers alone do not establish verified prespecification or identity."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Were different company-involvement items distinguished?",
      "needed": "Funding, product support, affiliations, analysis and publication roles",
      "role": "Required",
      "role_reason": "Material on Funding, product support, affiliations, analysis and publication roles is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Funding, product support, affiliations, analysis and publication roles must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original documents on financial and product support, company affiliations, design, analysis and publication roles are needed separately. One item does not establish absence of every form of involvement. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Beadle is reported as a military institutional study without manufacturer sponsorship; Candemir reports no COI with specific funding unverified; April reports academic research without manufacturer involvement. Detailed funding for the separate combined-drug comparison is unverified.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original documents on financial and product support, company affiliations, design, analysis and publication roles are needed separately. One item does not establish absence of every form of involvement.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original documents on financial and product support, company affiliations, design, analysis and publication roles are needed separately. One item does not establish absence of every form of involvement."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Were reports, reviews and subquestions double-counted?",
      "needed": "Reports, original trials, cohorts and shared relationships",
      "role": "Required",
      "role_reason": "Material on Reports, original trials, cohorts and shared relationships is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Reports, original trials, cohorts and shared relationships must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Included trials, time-specific analysis populations, reports and cohort identity tables are needed. Report slots, sheets and samples are not added as unique trials, participants or independent replications. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Both subquestions share the parent's Beadle, Candemir and April reports and separate Korean comparison context. The review synthesizes included trials, and the Korean 120-person description is not a separate evidence or bibliography entry.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Included trials, time-specific analysis populations, reports and cohort identity tables are needed. Report slots, sheets and samples are not added as unique trials, participants or independent replications.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Included trials, time-specific analysis populations, reports and cohort identity tables are needed. Report slots, sheets and samples are not added as unique trials, participants or independent replications."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "What is the level of the original independent-replication wording?",
      "needed": "Candemir support versus funding and prespecification gaps",
      "role": "Required",
      "role_reason": "Material on Candemir support versus funding and prespecification gaps is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Candemir support versus funding and prespecification gaps must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original registration, plans, institutions, recruitment, support and overlapping-report relationships are needed. Uncertain unique totals remain uncertain. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The parent's independent-replication wording and unverified funding, registration and prespecification are retained together. They are not promoted into current independence certification or a confirmed unique-trial total.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original registration, plans, institutions, recruitment, support and overlapping-report relationships are needed. Uncertain unique totals remain uncertain.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original registration, plans, institutions, recruitment, support and overlapping-report relationships are needed. Uncertain unique totals remain uncertain."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Were differing parent Korean and English contexts retained?",
      "needed": "Korean 30-minute, 3-arm findings versus English synthesis",
      "role": "Required",
      "role_reason": "Material on Korean 30-minute, 3-arm findings versus English synthesis is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Korean 30-minute, 3-arm findings versus English synthesis must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original trial and review result tables, denominators, times and effect comparisons are needed. Complete parent Korean and English accounts are preserved without new external comparison or correction. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The Korean account contains NCT02760069's 30-minute within-group VAS; the English account contains a 10-minute meta-analysis of two placebo-controlled trials and 195 participants. They are not substituted for each other as translations of the same report, time or effect.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original trial and review result tables, denominators, times and effect comparisons are needed. Complete parent Korean and English accounts are preserved without new external comparison or correction.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original trial and review result tables, denominators, times and effect comparisons are needed. Complete parent Korean and English accounts are preserved without new external comparison or correction."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Does stored-summary reading equal external-original reading?",
      "needed": "Report-specific summary, abstract, full-text, registration and plan status",
      "role": "Required",
      "role_reason": "Material on Report-specific summary, abstract, full-text, registration and plan status is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Report-specific summary, abstract, full-text, registration and plan status must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Actual acquisition or review requires separate identity, access and reading-level records. A URL alone does not establish reading, successful access or completed content review. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The complete stored parent summary was read. Historical verification and cross-check narratives are distinguished from actual reading here; external abstracts, full text, registration and plans remain unread.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Actual acquisition or review requires separate identity, access and reading-level records. A URL alone does not establish reading, successful access or completed content review.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual acquisition or review requires separate identity, access and reading-level records. A URL alone does not establish reading, successful access or completed content review."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are adverse-event collection, denominators and exposure known?",
      "needed": "Harm events, collection, severity, exposure and discontinuation",
      "role": "Supplementary",
      "role_reason": "Material on Harm events, collection, severity, exposure and discontinuation is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Harm events, collection, severity, exposure and discontinuation must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Active collection, events versus affected people, severity, onset, exposure, arm-specific denominators, discontinuation, rescue and causality-assessment material are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Parent safety cautions are preserved unchanged. April lists adverse events, but arm-specific event counts, collection methods, denominators and exposure quantities are unverified. Missing numbers are not converted into safety or absence of events.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Active collection, events versus affected people, severity, onset, exposure, arm-specific denominators, discontinuation, rescue and causality-assessment material are needed.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Active collection, events versus affected people, severity, onset, exposure, arm-specific denominators, discontinuation, rescue and causality-assessment material are needed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Can repeated or long-term exposure and vulnerable groups be assessed?",
      "needed": "Brief observation versus long-term, rare harms and vulnerable populations",
      "role": "Supplementary",
      "role_reason": "Material on Brief observation versus long-term, rare harms and vulnerable populations is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Brief observation versus long-term, rare harms and vulnerable populations must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Long-term and repeated exposure, vulnerable-group eligibility, arm-specific harm follow-up, denominators and actual exposure material are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The principal 10-minute and separate 30-minute results are not extended into safety verification for long-term or repeated exposure, pregnancy or respiratory vulnerability. Parent cautions are not turned into new procedure guidance.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Long-term and repeated exposure, vulnerable-group eligibility, arm-specific harm follow-up, denominators and actual exposure material are needed.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term and repeated exposure, vulnerable-group eligibility, arm-specific harm follow-up, denominators and actual exposure material are needed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "How do selected C, separate D and parent C54 differ?",
      "needed": "Selected and separate subclaim grades versus parent score, status and axes",
      "role": "Required",
      "role_reason": "Material on Selected and separate subclaim grades versus parent score, status and axes is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Selected and separate subclaim grades versus parent score, status and axes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Subclaim and parent records and application boundaries must be distinguished. Parent values do not overwrite subclaim D or create new scores, harm grades or independence certification. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Acute nausea is C and actual vomiting or cause treatment is D. Individual scores, status and axes are absent; parent C54, Caution and B/P/R1/I2/E+/B2/CX belong to the overall context.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Subclaim and parent records and application boundaries must be distinguished. Parent values do not overwrite subclaim D or create new scores, harm grades or independence certification.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Subclaim and parent records and application boundaries must be distinguished. Parent values do not overwrite subclaim D or create new scores, harm grades or independence certification."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "Are historical draft B and final C a new reassessment?",
      "needed": "Original grade-decision history versus current production",
      "role": "Required",
      "role_reason": "Material on Original grade-decision history versus current production is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Original grade-decision history versus current production must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: A requested verdict change requires preservation of complete originals, events, versions and reasons. This work retains original values. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The parent's draft B, final C, 54 points and cross-check record are historical. The grade was not reassessed in this production.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "A requested verdict change requires preservation of complete originals, events, versions and reasons. This work retains original values.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "A requested verdict change requires preservation of complete originals, events, versions and reasons. This work retains original values."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Were original dates, corrections and production times separated?",
      "needed": "Historical evidence date, empty corrections and deliberation versus new changes",
      "role": "Required",
      "role_reason": "Material on Historical evidence date, empty corrections and deliberation versus new changes is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Historical evidence date, empty corrections and deliberation versus new changes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Material additions, condition revisions, observation application and verdict changes must remain separate events, preserving previous originals. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The original date is 2026-09-07, corrections are an empty array and deliberation an empty string. The current production time does not become an evidence-verification date, and no absent correction is invented.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Material additions, condition revisions, observation application and verdict changes must remain separate events, preserving previous originals.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Material additions, condition revisions, observation application and verdict changes must remain separate events, preserving previous originals."
    }
  ],
  "reports": [
    {
      "report_id": "R01",
      "title": "Beadle KL et al. 2016",
      "url": "https://pubmed.ncbi.nlm.nih.gov/26679977/",
      "report_type": "Randomized alcohol-versus-saline odor trial; principal 10-minute nausea NRS",
      "existence": "This is report and bibliographic information or separate explanatory context in the preserved parent account. Current external identity, content, registration and detailed-material verification was not performed.",
      "acquired_read": "Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.",
      "study_family": "Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.",
      "independent_replication": "Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.",
      "observed_result": "The record states 84 recruited, 80 completed, 37 alcohol and 43 saline. Original 10-minute medians of 3 versus 6, difference 3 (95% CI 2 to 4), satisfaction +2 and null rescue use are retained.",
      "result_level": "This is a stored summary of direct NRS findings. Recruitment, completion, analysis wording and endpoint-specific denominators are distinguished; historical registration and verification narratives are not promoted into current external verification.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "Protocol and analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "PMID26679977, DOI10.1016/j.annemergmed.2015.09.031 and NCT02092441 are linked to the original bibliography. Military institutional research, no manufacturer sponsorship and prospective-registration wording are original records, not current external verification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/26679977/"
        }
      ]
    },
    {
      "report_id": "R02",
      "title": "Candemir H et al. 2021",
      "url": "https://pubmed.ncbi.nlm.nih.gov/33373914/",
      "report_type": "Prospective randomized placebo-controlled trial; repeated-time nausea and rescue treatment",
      "existence": "This is report and bibliographic information or separate explanatory context in the preserved parent account. Current external identity, content, registration and detailed-material verification was not performed.",
      "acquired_read": "Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.",
      "study_family": "Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.",
      "independent_replication": "Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.",
      "observed_result": "The report records 118 in ITT, 115 completed, nausea NRS at 2, 4 and 10 minutes and rescue treatment. The overall between-group effect from 2 minutes, P=.008, and less rescue treatment are retained without copying identical effects or CIs to each time.",
      "result_level": "Original independent-replication wording is retained together with unverified specific funding, registration and prespecification. No current independence certification or confirmed unique-trial total is created.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "Protocol and analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "PMID33373914 and DOI10.1016/j.ajem.2020.12.052 are linked to the original bibliography. Reported absence of COI is distinguished from unverified specific funding, original registration and prespecification. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/33373914/"
        }
      ]
    },
    {
      "report_id": "R03",
      "title": "April MD et al. 2023",
      "url": "https://pubmed.ncbi.nlm.nih.gov/37076258/",
      "report_type": "Systematic review and meta-analysis; quantitative synthesis of included trials",
      "existence": "This is report and bibliographic information or separate explanatory context in the preserved parent account. Current external identity, content, registration and detailed-material verification was not performed.",
      "acquired_read": "Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.",
      "study_family": "Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.",
      "independent_replication": "Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.",
      "observed_result": "The original record retains 2 saline-controlled RCTs, 195 participants, 10-minute MD -2.18/10 (95% CI -2.76 to -1.60), MCID 1.5 and moderate certainty.",
      "result_level": "These are the original review's criteria and certainty narratives. Externally validated important differences, extraction from included trials and overlap remain unverified; the review is not counted as a new original trial or current official GRADE assessment.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "Protocol and analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "PMID37076258, DOI10.1136/emermed-2022-212871 and CRD42022299815 are retained. CRD identifies review registration, not an original clinical-trial NCT or registration reading in this work. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/37076258/"
        }
      ]
    },
    {
      "report_id": "R04",
      "title": "Separate 3-arm summary in the stored Korean account",
      "url": null,
      "report_type": "Korean context concerning NCT02760069; no separate evidence or bibliography entry",
      "existence": "This is report and bibliographic information or separate explanatory context in the preserved parent account. Current external identity, content, registration and detailed-material verification was not performed.",
      "acquired_read": "Only the complete stored parent summary and bibliography were read. External abstracts, full text, registration, plans, harms and support materials are unread.",
      "study_family": "Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.",
      "independent_replication": "Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified.",
      "observed_result": "The 120-person, 3-arm, 30-minute within-group VAS reductions are 30mm with alcohol, 32mm with ondansetron plus alcohol and 9mm with ondansetron plus saline. This remains separate Korean context without new between-group effects, CIs or NRS conversion.",
      "result_level": "This is preserved context from the parent Korean explanation. Detailed bibliography, an original-text URL, arm-specific analysis denominators and original between-group results are unlinked; no external link is newly inferred.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        },
        {
          "material_type": "Protocol and analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "NCT02760069 appears in the stored Korean explanation. A separate evidence entry, bibliography and paper URL are absent and are not newly filled or promoted into acquired bibliography. Stored-summary dates are historical markers of the original evidence date. Empty dates for unread external materials remain empty; historical verification narratives and identifiers are not promoted into current reading or review."
        }
      ],
      "links": []
    }
  ],
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "Selected nausea, separate vomiting and the parent account share reports. The review, included trials and separate Korean combined-drug comparison context are distinguished; report slots are not added as new independent trials. Unique trial, participant and independent-replication totals remain unverified."
  },
  "history": [
    {
      "date": "2026-10-20",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "Public-facing views and materials were prepared from the existing 30 items. No new clinical search, verification-status change or scoring was performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-20"
}