{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Isopropyl-alcohol pad × Acute ED nausea—subjective symptoms at 10 minutes",
  "language": "en",
  "translation_date": "2026-10-20",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which acute-nausea question is addressed?",
      "needed": "Selected 10-minute nausea question, original grade and note versus separate vomiting",
      "role": "Required",
      "role_reason": "Material on Selected 10-minute nausea question, original grade and note versus separate vomiting is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Selected 10-minute nausea question, original grade and note versus separate vomiting must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original direct comparisons, arm-specific denominators, target effects, CIs and selected versus parent boundaries are needed. No new question, independence certification or subclaim score is created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "What is Beadle's direct 10-minute result?",
      "needed": "Original 10-minute NRS findings, difference, CI and comparison",
      "role": "Required",
      "role_reason": "Material on Original 10-minute NRS findings, difference, CI and comparison is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Original 10-minute NRS findings, difference, CI and comparison must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Scale range, direction, baseline, estimation methods, the effect targeted by the CI and arm-specific analysis denominators are needed. Findings are not transferred to other times or scales. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Do recruitment, completion and arm counts share an analysis denominator?",
      "needed": "Beadle recruitment, completion, analysis and arm counts",
      "role": "Required",
      "role_reason": "Material on Beadle recruitment, completion, analysis and arm counts is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Beadle recruitment, completion, analysis and arm counts must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original flow, analysis populations, nausea, satisfaction and rescue denominators and missing-data handling are needed. No new attrition or event count is calculated from differences. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Is MCID 1.5 the same as an externally validated important difference?",
      "needed": "Prespecified criteria, review effects and external clinical importance",
      "role": "Required",
      "role_reason": "Material on Prespecified criteria, review effects and external clinical importance is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Prespecified criteria, review effects and external clinical importance must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: MCID sources, prespecification, patient-important criteria, measurement tools, effect distributions and responder data are needed. This is not promoted into current official GRADE certification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Is satisfaction +2 a nausea or vomiting effect?",
      "needed": "Satisfaction measures versus nausea NRS and vomiting events",
      "role": "Required",
      "role_reason": "Material on Satisfaction measures versus nausea NRS and vomiting events is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Satisfaction measures versus nausea NRS and vomiting events must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Satisfaction tools, timing, denominators, between-group estimates, CIs and prespecified hierarchy are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Were rescue-antiemetic findings the same in every trial?",
      "needed": "Rescue medication and treatment versus other endpoints",
      "role": "Required",
      "role_reason": "Material on Rescue medication and treatment versus other endpoints is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Rescue medication and treatment versus other endpoints must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Rescue criteria, drugs, exposure, timing, denominators, between-group effects, CIs and concurrent care are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "What are Candemir's repeated-time results?",
      "needed": "NRS at 2, 4 and 10 minutes and the overall between-group analysis",
      "role": "Required",
      "role_reason": "Material on NRS at 2, 4 and 10 minutes and the overall between-group analysis is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on NRS at 2, 4 and 10 minutes and the overall between-group analysis must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Time-specific effects, CIs, denominators, repeated-measures models, multiple comparisons and prespecified hierarchy are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Are 10-minute NRS and 30-minute within-group VAS the same?",
      "needed": "NCT02760069's separate 3-arm, 30-minute comparison",
      "role": "Required",
      "role_reason": "Material on NCT02760069's separate 3-arm, 30-minute comparison is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on NCT02760069's separate 3-arm, 30-minute comparison must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original 3-arm material, arm-specific allocation and analysis, interventions, concurrent drugs, timing, between-group VAS effects, CIs and prespecified plans are needed. No scale conversion or new between-group CI is created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What do the review's 2 RCTs and 195 participants represent?",
      "needed": "April synthesis, included trials and extraction denominators",
      "role": "Required",
      "role_reason": "Material on April synthesis, included trials and extraction denominators is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on April synthesis, included trials and extraction denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Included-trial identities, time- and scale-specific extraction denominators, overlap, meta-analysis methods, bias and certainty materials are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Were within-group changes distinguished from direct between-group results?",
      "needed": "Study-specific target effects and analysis levels",
      "role": "Required",
      "role_reason": "Material on Study-specific target effects and analysis levels is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Study-specific target effects and analysis levels must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Baseline adjustment, change and endpoint comparisons, models and original between-group estimates and CIs are needed. No new between-group effect is calculated by subtracting within-group values. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Were registration and subjective-endpoint limitations retained together?",
      "needed": "Original prespecification narrative, small samples and ultra-short measurement",
      "role": "Required",
      "role_reason": "Material on Original prespecification narrative, small samples and ultra-short measurement is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Original prespecification narrative, small samples and ultra-short measurement must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original registration, changes, prespecified endpoints, analyses, allocation, measurement and missing-data material are needed. Selected C is not promoted into a new grade. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Does a brief nausea-score result establish less actual vomiting?",
      "needed": "Subjective nausea versus separate vomiting-event evidence",
      "role": "Required",
      "role_reason": "Material on Subjective nausea versus separate vomiting-event evidence is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Subjective nausea versus separate vomiting-event evidence must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Vomiting definitions, report identity, events versus people, timing, denominators, between-group effects and CIs are needed. Nausea effects are not converted into reduced vomiting. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Does 10-minute relief establish cause treatment or less clinical care?",
      "needed": "Underlying diagnosis, treatment, fluids and concurrent care boundaries",
      "role": "Required",
      "role_reason": "Material on Underlying diagnosis, treatment, fluids and concurrent care boundaries is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Underlying diagnosis, treatment, fluids and concurrent care boundaries must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Direct studies and denominators for cause-specific diagnosis, treatment, care, fluids and important clinical outcomes are needed. No new administration, procedure or care guidance is created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Do short-term findings establish durability or recurrence effects?",
      "needed": "A 10-minute endpoint versus long-term and recurrent nausea",
      "role": "Required",
      "role_reason": "Material on A 10-minute endpoint versus long-term and recurrent nausea is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on A 10-minute endpoint versus long-term and recurrent nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Longer follow-up, recurrence, rescue, cause treatment, concurrent care and corresponding analysis denominators are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Which emergency-department adults were studied?",
      "needed": "Eligibility, causes and baseline severity in acute nausea",
      "role": "Required",
      "role_reason": "Material on Eligibility, causes and baseline severity in acute nausea is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Eligibility, causes and baseline severity in acute nausea must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Cause-specific recruitment, baseline NRS, comorbidities, emergency conditions, exclusions and trial-specific recruitment methods are needed. Findings are not extended to other populations or settings. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "What are the formulation and route boundaries for the 70% pad?",
      "needed": "Original formulation, concentration, exposure and intervention boundaries",
      "role": "Required",
      "role_reason": "Material on Original formulation, concentration, exposure and intervention boundaries is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Original formulation, concentration, exposure and intervention boundaries must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original products, manufacturing, pad volume, exposure criteria and comparability between arms are needed. No new procedure or administration method is created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Are saline-odor control and drug comparisons the same?",
      "needed": "Controls, concurrent drugs, rescue medication and target effects",
      "role": "Required",
      "role_reason": "Material on Controls, concurrent drugs, rescue medication and target effects is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Controls, concurrent drugs, rescue medication and target effects must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Arm-specific interventions, concurrent antiemetics, allocation, rescue criteria, target effects and original between-group results are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Were recruitment, completion, ITT and endpoint denominators distinguished?",
      "needed": "Trial flow and valid arm- and endpoint-specific denominators",
      "role": "Required",
      "role_reason": "Material on Trial flow and valid arm- and endpoint-specific denominators is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Trial flow and valid arm- and endpoint-specific denominators must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Recruitment, allocation, completion, time-specific assessments, analysis, arm-specific missingness and ITT definitions are needed. No new differences or participant totals are calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "What are odor-related blinding limitations?",
      "needed": "Allocation, concealment, subjective-score collection and expectations",
      "role": "Required",
      "role_reason": "Material on Allocation, concealment, subjective-score collection and expectations is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Allocation, concealment, subjective-score collection and expectations must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Allocation, concealment, people blinded, blinding success, NRS collectors, procedures, losses and revealing cues are needed. No new official RoB2 judgment is made. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Does a registration number mean external registration was read?",
      "needed": "Trial registration, review registration and prespecification material",
      "role": "Required",
      "role_reason": "Material on Trial registration, review registration and prespecification material is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Trial registration, review registration and prespecification material must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Each trial's and review's original registration, changes, protocol, analysis plans, prespecified endpoints and denominators must be distinguished. Numbers alone do not establish verified prespecification or identity. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Were different company-involvement items distinguished?",
      "needed": "Funding, product support, affiliations, analysis and publication roles",
      "role": "Required",
      "role_reason": "Material on Funding, product support, affiliations, analysis and publication roles is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Funding, product support, affiliations, analysis and publication roles must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original documents on financial and product support, company affiliations, design, analysis and publication roles are needed separately. One item does not establish absence of every form of involvement. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Were reports, reviews and subquestions double-counted?",
      "needed": "Reports, original trials, cohorts and shared relationships",
      "role": "Required",
      "role_reason": "Material on Reports, original trials, cohorts and shared relationships is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Reports, original trials, cohorts and shared relationships must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Included trials, time-specific analysis populations, reports and cohort identity tables are needed. Report slots, sheets and samples are not added as unique trials, participants or independent replications. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "What is the level of the original independent-replication wording?",
      "needed": "Candemir support versus funding and prespecification gaps",
      "role": "Required",
      "role_reason": "Material on Candemir support versus funding and prespecification gaps is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Candemir support versus funding and prespecification gaps must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original registration, plans, institutions, recruitment, support and overlapping-report relationships are needed. Uncertain unique totals remain uncertain. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Were differing parent Korean and English contexts retained?",
      "needed": "Korean 30-minute, 3-arm findings versus English synthesis",
      "role": "Required",
      "role_reason": "Material on Korean 30-minute, 3-arm findings versus English synthesis is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Korean 30-minute, 3-arm findings versus English synthesis must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Original trial and review result tables, denominators, times and effect comparisons are needed. Complete parent Korean and English accounts are preserved without new external comparison or correction. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Does stored-summary reading equal external-original reading?",
      "needed": "Report-specific summary, abstract, full-text, registration and plan status",
      "role": "Required",
      "role_reason": "Material on Report-specific summary, abstract, full-text, registration and plan status is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Report-specific summary, abstract, full-text, registration and plan status must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Actual acquisition or review requires separate identity, access and reading-level records. A URL alone does not establish reading, successful access or completed content review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are adverse-event collection, denominators and exposure known?",
      "needed": "Harm events, collection, severity, exposure and discontinuation",
      "role": "Supplementary",
      "role_reason": "Material on Harm events, collection, severity, exposure and discontinuation is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Harm events, collection, severity, exposure and discontinuation must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Active collection, events versus affected people, severity, onset, exposure, arm-specific denominators, discontinuation, rescue and causality-assessment material are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Can repeated or long-term exposure and vulnerable groups be assessed?",
      "needed": "Brief observation versus long-term, rare harms and vulnerable populations",
      "role": "Supplementary",
      "role_reason": "Material on Brief observation versus long-term, rare harms and vulnerable populations is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Brief observation versus long-term, rare harms and vulnerable populations must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Long-term and repeated exposure, vulnerable-group eligibility, arm-specific harm follow-up, denominators and actual exposure material are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "How do selected C, separate D and parent C54 differ?",
      "needed": "Selected and separate subclaim grades versus parent score, status and axes",
      "role": "Required",
      "role_reason": "Material on Selected and separate subclaim grades versus parent score, status and axes is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Selected and separate subclaim grades versus parent score, status and axes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Subclaim and parent records and application boundaries must be distinguished. Parent values do not overwrite subclaim D or create new scores, harm grades or independence certification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "Are historical draft B and final C a new reassessment?",
      "needed": "Original grade-decision history versus current production",
      "role": "Required",
      "role_reason": "Material on Original grade-decision history versus current production is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Original grade-decision history versus current production must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: A requested verdict change requires preservation of complete originals, events, versions and reasons. This work retains original values. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Were original dates, corrections and production times separated?",
      "needed": "Historical evidence date, empty corrections and deliberation versus new changes",
      "role": "Required",
      "role_reason": "Material on Historical evidence date, empty corrections and deliberation versus new changes is needed to connect the selected nausea question with controls, scales, times, original reports, denominators, precision and harm boundaries.",
      "application_exception": "Selected C and absent individual score, status and axes are retained without substituting parent C54 or separate vomiting D. Reported values, within-group changes, between-group effects, reviews and included trials are distinguished. No new effect, CI, scale conversion, unique total, grade, procedure, administration or individual-care guidance is created.",
      "criterion": "Original material on Historical evidence date, empty corrections and deliberation versus new changes must link to the relevant report, comparator, endpoint, time, denominators and analysis, distinguishing selected nausea, separate vomiting and cause treatment, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing acute-nausea question. They do not establish preregistration, use of an official assessment tool or completed clinical content review.",
      "proposed_research": "Material needed: Material additions, condition revisions, observation application and verdict changes must remain separate events, preserving previous originals. This records needed materials; no new research was executed."
    }
  ]
}