30% MVC handgrip × supervised office SBP: evidence checklist

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionWhich supervised office-SBP claim is selected?Required	The selection is lower supervised office SBP. Preserve original grade C and the note supporting direction in small trials with incomplete specific adjusted effects. Home training, home pressure and 24-hour ambulatory pressure are separate. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Selected claim, grade, note and measurement-setting boundaries	Material needed: Supervision, comparator, timing, denominators and adjusted direct effects/CIs are unverified. Create no new independent claims or scores. This records needed materials; no new research was executed.
2	Partly verified	Full text not readStored summary read	N02 · Evidence conditionWhat is Farah's office-SBP test across 3 arms?Required	Preserve office SBP P=.041 in 72 randomized treated participants with hypertension over 12 weeks in supervised/home/no-exercise 3-arm conditions. The original text describes this as an omnibus group-by-time test. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Omnibus group-by-time test, original model and denominators	Material needed: Original models, arm/time values, adjusted pairwise comparisons, denominators, direct effects/95% CIs and multiple comparisons are unverified. This P alone does not establish specific pairwise effects. This records needed materials; no new research was executed.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionWhich pairwise difference does the omnibus test establish?Required	P=.041 for the 3-arm/time test does not show that supervised/no-exercise, supervised/home and home/no-exercise comparisons all have the same effect or significance. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Omnibus 3-arm testing versus specific adjusted comparisons	Material needed: Planned comparisons, baseline adjustment, estimates/CIs, denominators, analysis populations and original tables are unverified. Do not fill in absent pairwise values, CIs or P. This records needed materials; no new research was executed.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionCan SBP and DBP tests be combined?Required	Farah office DBP P=.049 and SBP P=.041 are omnibus tests for different endpoints. Significant DBP also differs from a specific adjusted pairwise difference or everyday pressure benefit. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Office systolic/diastolic outcomes and precision	Material needed: Original arm values, specific comparisons, CIs, denominators, planned hierarchy and multiple testing are unverified. Do not copy DBP results into SBP effects. This records needed materials; no new research was executed.
5	Partly verified	Full text not readStored summary read	N05 · Evidence conditionAre office, central and ambulatory pressure the same outcome?Required	Farah covers office, central and 24-hour ambulatory pressure, and its bibliography mentions brachial/central pressure. Original P values concern office and ambulatory outcomes; exact central-pressure effects/CIs are not provided. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Measurement locations, settings, devices, timing and denominators	Material needed: Locations, devices, conditions, timing, denominators, between-group comparisons/CIs and planned hierarchy are unverified. Do not estimate central values or combine all as the same SBP effect. This records needed materials; no new research was executed.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionIs a within-group reduction an added benefit over control?Required	The original text does not turn within-group reductions into specific between-group effects. Distinguish directional supervised office signals from baseline/follow-up changes. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Within-group changes versus direct between-group effects	Material needed: Baseline/follow-up values, adjusted models, specific comparisons, arm denominators and original effects/CIs are unverified. Do not subtract changes to create new control-relative effects. This records needed materials; no new research was executed.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionWere figure/table arm-label inconsistencies resolved?Required	Original explanations and bibliographic notes identify figure/table arm-label inconsistencies. Do not arbitrarily assign numbers to arms and read them as specific pairwise effects. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original figures, tables, legends and arm attribution	Material needed: Complete original figures/tables, legends, arm keys, underlying data, explanations and corrections are needed. Production did not resolve these inconsistencies or edit values. This records needed materials; no new research was executed.
8	Partly verified	Full text not readStored summary read	N08 · Evidence conditionWhat were Palmeira's supportive and null results?Required	Palmeira is preserved as a 63-participant, 12-week randomized trial with positive office-SBP interaction and null DBP/ambulatory pressure. Exact SBP effects/CIs, P and arm denominators are absent from the summary. R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Office-SBP interaction versus DBP and ambulatory pressure	Material needed: Original models, arm denominators, baseline/follow-up, endpoint comparisons/CIs and planned analyses are unverified. Do not copy Farah P into this report. This records needed materials; no new research was executed.
9	Partly verified	Full text not readStored summary read	N09 · Evidence conditionWere large attrition and analysis denominators verified?Required	Palmeira bibliography records 63 participants and large attrition. Exact completion/analysis counts, arm imbalances and missing-data handling are absent from the summary. Do not treat all participants as completers for every endpoint. R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Randomization, completion, missingness, ITT, sensitivity and time-specific denominators	Material needed: Original flow charts, arm allocation/completion, missingness/withdrawal reasons, ITT, analyses, sensitivity and time-specific denominators are unverified. Calculate no new withdrawal counts, rates or effects. This records needed materials; no new research was executed.
10	Partly verified	Full text not readStored summary read	N10 · Evidence conditionCan supervised results be transferred to home training?Required	The original text does not transfer supervised results to unsupervised home training. Distinguish Farah 3-arm conditions from null results in the 2024 home-training report with 84 participants. R01 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Training location, supervision, contact, actual exposure and adherence	Material needed: Actual intensity, exposure, contact, adherence, comparators and original comparisons/denominators are unverified. Do not equate supervised/home conditions or create new exercise methods. This records needed materials; no new research was executed.
11	Partly verified	Full text not readStored summary read	N11 · Evidence conditionAre home training and home pressure measurement the same?Required	The original text distinguishes home-training conditions from office, home and 24-hour measurements. Training at home does not establish a comparison using home-pressure values. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Intervention delivery location versus outcome measurement setting	Material needed: Original data separating training location/supervision from measurement location, devices, schedules, denominators, timing and specific comparisons are needed. Exact home-pressure effects are absent from the summary. This records needed materials; no new research was executed.
12	Partly verified	Full text not readStored summary read	N12 · Evidence conditionHow does null 24-hour pressure limit the office signal?Required	In the same Farah trial, 24-hour ambulatory SBP P=.650 and DBP P=.340 are null. Do not extend office signals into all-day pressure reduction. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Setting-specific tests, original values, between-group effects and denominators	Material needed: Setting-specific original values, between-group CIs, denominators, devices, valid measurements, timing and effects of interest are unverified. Null does not certify exact effect 0 or equivalence. This records needed materials; no new research was executed.
13	Partly verified	Full text not readStored summary read	N13 · Evidence conditionDoes office SBP establish day/night or clinical-event benefit?Required	The original text limits conclusions by measurement setting and surrogate outcomes; office results do not establish everyday pressure benefit or medication replacement. Direct day/night or disease-event effects/CIs are absent. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Surrogates, day/night/ambulatory pressure and long-term clinical-event boundaries	Material needed: Day/night definitions, measurements/denominators, between-group effects/CIs, clinical importance and direct long-term event data are needed. Create no new medication reduction/replacement or treatment instructions. This records needed materials; no new research was executed.
14	Partly verified	Full text not readStored summary read	N14 · Evidence conditionDo signals across studies establish precise independent replication?Required	The original text describes supervised office-SBP signals across trials as a strength. Preserve original I2/R1 axes without upgrading directions from different controls, within-group changes or omnibus tests into new independent confirmation. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Matched supervision/controls, institutions, recruitment and report/participant relationships	Material needed: Institutions, recruitment/registration, support, report/participant overlap, matched supervision/controls and original effects/CIs are unverified. Do not fill in unique-trial/participant totals. This records needed materials; no new research was executed.
15	Partly verified	Full text not readStored summary read	N15 · Evidence conditionWho were the participants and what was their medication status?Required	Farah randomized 72 treated participants with hypertension; Palmeira concerns primary-care hypertension; the 2024 report concerns older home-training participants. Original counts and representative information do not establish identical populations. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Diagnosis, baseline control, medication, age, comorbidities and eligibility	Material needed: Diagnosis, baseline control, medication/changes, age, comorbidities, recruitment/exclusions and arm denominators are unverified. Do not extend this to untreated, other-patient or vulnerable populations. This records needed materials; no new research was executed.
16	Partly verified	Full text not readStored summary read	N16 · Evidence conditionAre representative training conditions instructions?Supplementary	Original representative conditions are 30% MVC, 4 holds of 2 minutes, 3 times weekly. Preserve them as study identifiers; actual intensity and adherence are unverified. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original intensity, exposure, delivery and actual adherence	Material needed: Original devices, intensity measurement, exposure/sessions, supervision/contact, adherence and control records are needed. Calculate no new total time/exposure or exercise, breathing or treatment steps. This records needed materials; no new research was executed.
17	Partly verified	Full text not readStored summary read	N17 · Evidence conditionWere different comparators distinguished?Required	The original text distinguishes trials of supervised/home training with 5% MVC sham, no-exercise and aerobic controls. Do not fill in the same comparator/blinding conditions for all reports. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Sham, no-exercise and aerobic controls and effects of interest	Material needed: Report-specific control intensity, exposure, contact, baseline adjustment, planned comparisons and denominators are unverified. Do not interchange comparator-specific effects. This records needed materials; no new research was executed.
18	Partly verified	Full text not readStored summary read	N18 · Evidence conditionWere concurrent medication, activity and supervisory contact verified?Required	The original text records treated participants and supervised/home conditions. Medication types, doses, changes, baseline activity, premeasurement conditions, contact and actual exposure details are absent. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Concurrent treatment, changes, actual exposure, measurement conditions and attribution	Material needed: Arm medication/changes, concurrent activity, adherence, measurement conditions, models, denominators and original effects are needed. Do not establish identical conditions or effects without medication. This records needed materials; no new research was executed.
19	Partly verified	Full text not readStored summary read	N19 · Evidence conditionWere randomization, blinding, measurement and timing verified?Required	Original evidence labels randomized trials, but allocation, concealment, evaluators, standardized measurement, prospective planning, multiple time points and detailed attrition are absent from summaries. Preserve original B2 and small-sample/attrition limitations. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Allocation, concealment, evaluators, standardized measurement, planning and missingness	Material needed: Original methods, measurement procedures, blinding, baseline adjustment/missingness, planned endpoints/comparisons/timing and analysis plans are needed. Create no official method-assessment pass or new grade. This records needed materials; no new research was executed.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionAre registration identifiers equivalent to reading original plans?Required	Farah NCT02348138 and Palmeira NCT03216317 are original identifiers; registration for the 2024 report is unverified. PMCID is preserved in the bibliography; external registration, plans, full texts and prospective-status comparisons were unread this run. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Registration, paper linkage, changes, protocols, SAPs and planned endpoints	Material needed: Original registration, changes, paper linkage, protocols/SAPs, planned endpoints, arm comparisons and denominators are needed. Identifiers, URLs and PMCID alone do not establish reading or prospective verification. This records needed materials; no new research was executed.
21	Partly verified	Full text not readStored summary read	N21 · Evidence conditionWhat were funding, products, employee authors and design/analysis roles?Required	Preserve Farah public/academic support, Palmeira public primary-care support and the 2024 report's academic support. Public/academic wording or parent I2 does not become new certification of overall independence. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Financial/device/product support, author affiliations and design/analysis/publication control	Material needed: Disclosures of financial/device/product support, company/author affiliations, design/analysis/publication roles and institutional, recruitment and report relationships are unread. Do not fill in no support or involvement. This records needed materials; no new research was executed.
22	Partly verified	Full text not readStored summary read	N22 · Evidence conditionWere pain, exercise pressure and vulnerable-group harms verified?Supplementary	Original safety text records hand/arm pain, pressure rises during breath-holding/Valsalva and uncontrolled-hypertension/cardiovascular-disease boundaries. Trial-specific harm events, exposure, denominators and collection are absent from summaries. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Events, affected people, arm denominators, exposure, collection, stopping and follow-up	Material needed: Harm collection, severity/timing, events/affected people, denominators, actual exposure, stopping, medication/vulnerable groups and long-term data are needed. Null ambulatory pressure does not become no harm or safety certification. This records needed materials; no new research was executed.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionAre subclaim grades the same as parent scores and axes?Required	Supervised office subclaim C and ambulatory subclaim D have no individual score, status or axes. Preserve parent C with 50 points, caution, B/S/R1/I2/EX/B2 and unrecorded precision as parent context. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Absent subclaim score/status/axes versus the parent verdict	Material needed: Do not fill subclaims with parent scores/axes or turn unrecorded precision into default values, new scores or independence certification. Distinguish parent/subclaim application boundaries. This records needed materials; no new research was executed.
24	Partly verified	Full text not readStored summary read	N24 · Evidence conditionHow are representative information and both languages preserved?Required	Preserve complete bilingual texts and representative information. Representative 72 participants, 12 weeks, no exercise and office/central/ambulatory labels do not automatically apply to 63 or 84 participants, all day/night/home outcomes or each arm. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Report-specific populations, supervision, measurement settings, outcomes, timing and denominators	Material needed: Report-specific delivery, supervision, measurement settings, endpoints, timing, denominators and original English comparison materials are needed. No external English comparison or correction review was performed this run. This records needed materials; no new research was executed.
25	Partly verified	Full text not readStored summary read	N25 · Evidence conditionHow are actual reading and report/material counts distinguished?Required	The complete parent JSON was read for production. Historical verification, separation and cross-checks remain historical records; external materials are unread. Report/material counts do not count acquired papers, independent trials, participants or quality scores. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Stored summaries, external reading and trial/report/cohort relationships	Material needed: Original-material acquisition, actual reading and trial/report/cohort relationships are unverified. URLs/identifiers alone do not establish completed reading or unique-trial/participant totals. This records needed materials; no new research was executed.
26	Partly verified	Full text not readStored summary read	N26 · Evidence conditionWhat are the evidence date and correction history?Required	Preserve original evidence date 2026-09-07 and empty correction/deliberation records. Figure/table inconsistencies do not justify inventing corrections or turning production dates into evidence-verification dates. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original date, empty correction/deliberation records, production timing and original URLs	Material needed: When originals/corrections are acquired, preserve and link complete texts, events, versions and reasons. No original-verdict change or external lookup was performed this run. This records needed materials; no new research was executed.
27	Partly verified	Full text not readStored summary read	N27 · Evidence conditionHow will new materials and changed questions be updated?Required	Preserve original materials, conditions and observations. New materials are linked to supervision/controls, measurement settings, denominators, endpoints/timing/day-night, related reports and subclaim scope; no new lookup or reassessment occurred this run. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Evidence updates, criteria revisions and original-verdict changes	Material needed: Updates must retain complete texts, criteria versions, events and reasons. Do not invent clinical calculations, effects/CIs, independence certification, exercise methods, pressure-medication reduction/replacement or treatment instructions. This records needed materials; no new research was executed.

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27 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-09-07
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: Farah randomized 72 treated participants with hypertension; Palmeira has 63 primary-care participants with hypertension; the 2024 report has 84 older home-training participants. Arm eligibility, baseline control, medication changes, comorbidities and outcome-specific analysis denominators are unverified. Do not add these different participant counts.
Ingredient, formulation and route: Isometric handgrip training referenced to maximal voluntary contraction (MVC). Distinguish supervised delivery from unsupervised home training. Supervisory contact, actual intensity, devices, adherence and component contributions are unverified. Do not transfer supervised results to home training.
Dose: Original representative study conditions are 30% MVC, 4 holds of 2 minutes, 3 times weekly. Actual exposure, adherence and discontinuation are unverified. Calculate no new total time/exposure and do not turn these into personal exercise/breathing procedures, medication reduction/replacement or treatment instructions.
Comparator: Distinguish Farah supervised, home and no-exercise 3-arm conditions. Original 5% MVC sham, no-exercise and aerobic controls concern different trial contexts; do not fill in the same comparator for every report. Arm contact, exposure, medication/lifestyle care and adjusted effects for specific comparisons are unverified.
Measured outcome: The selection is supervised office SBP. Farah office SBP P=.041 and DBP P=.049 are omnibus 3-arm group-by-time tests; a specific adjusted pairwise effect/95% CI is unverified. Distinguish the same trial's null 24-hour ambulatory SBP P=.650/DBP P=.340 and office, central and home measurements.
Duration: Key Farah and Palmeira trials span 12 weeks. Exact duration of 2024 home training, detailed outcome timing, post-training persistence, long-term harms and clinical events are unverified. Do not turn a 24-hour measurement window into training duration or all-day benefit.
Questions outside this scope: Turning a 3-arm omnibus test or within-group reduction into a specific adjusted pairwise effect/CI; Combining office SBP/DBP, central, home, 24-hour and day/night results into one effect; Extending supervised signals into unsupervised home training, all-day pressure reduction or medication replacement; Turning null results into exact effect 0, equivalence or safety certification; Arbitrarily resolving figure/table arm-label inconsistencies or creating new numbers, CIs or totals; Using shared reports/participants, academic support or parent C with 50 points as new independence, precision or subclaim scores; Creating new exercise methods, breathing procedures, medication reduction/replacement or treatment instructions

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

R01 · Farah BQ, et al. Supervised, but Not Home-Based, Isometric Training Improves Brachial and Central Blood Pressure in Medicated Hypertensive Patients. Front Physiol. 2018;9:961. PMID: 30083107. PMCID: PMC6065303. DOI: 10.3389/fphys.2018.00961.

PubMed

Material type: Three-arm supervised, home, and no-exercise randomized trial
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary: Office SBP P=.041 and DBP P=.049; ambulatory SBP P=.650 and DBP P=.340
Record level: Medicated hypertension, 72 randomized, 12 weeks and supervised/home/no-exercise 3-arm conditions. Office SBP P=.041 and DBP P=.049 are omnibus group-by-time tests; specific adjusted effects/95% CIs are unverified. Preserve null 24-hour SBP P=.650/DBP P=.340, figure/table arm-label inconsistencies and missing exact arm denominators.
Study overlap and independent replication: Supervised office SBP and the separate ambulatory-pressure question share Farah, Palmeira and the 2024 home-training reports. Report/cohort relationships and unique-trial/participant totals are unverified. Multiple sheets, measures and report participants are not counted as new independent trials or participant totals.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies.

R02 · Palmeira AC, et al. Effects of isometric handgrip training on blood pressure among hypertensive patients seen within public primary healthcare: a randomized controlled trial. Sao Paulo Med J. 2021;139:648-656. PMID: 34787298. PMCID: PMC9634841. DOI: 10.1590/1516-3180.2020.0796.R1.22042021.

PubMed

Material type: Twelve-week randomized controlled trial
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary: Office SBP interaction positive; DBP and ambulatory pressure null
Record level: In a 63-participant, 12-week randomized primary-care hypertension trial, preserve positive office-SBP interaction and null DBP/ambulatory pressure. Exact completion/analysis counts amid large attrition, arm denominators, original effects/CIs, P and models are unverified; do not copy P from the key trial.
Study overlap and independent replication: Supervised office SBP and the separate ambulatory-pressure question share Farah, Palmeira and the 2024 home-training reports. Report/cohort relationships and unique-trial/participant totals are unverified. Multiple sheets, measures and report participants are not counted as new independent trials or participant totals.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans.

R03 · Home-based isometric handgrip training in older adults with hypertension. J Am Geriatr Soc. 2024. PMID: 39392028. DOI: 10.1111/jgs.19213.

PubMed

Material type: Randomized home-training trial in older adults
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary: 24-hour ambulatory and between-group office pressure were null
Record level: Preserve null 24-hour and between-group office pressure in the 2024 report of 84 older home-training participants. This does not replicate supervised effects under the same conditions; exact duration, comparator, effects/CIs, P and arm denominators are unverified.
Study overlap and independent replication: Supervised office SBP and the separate ambulatory-pressure question share Farah, Palmeira and the 2024 home-training reports. Report/cohort relationships and unique-trial/participant totals are unverified. Multiple sheets, measures and report participants are not counted as new independent trials or participant totals.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading.

Report counts versus independent study counts

Supervised office SBP and the separate ambulatory-pressure question share Farah, Palmeira and the 2024 home-training reports. Report/cohort relationships and unique-trial/participant totals are unverified. Multiple sheets, measures and report participants are not counted as new independent trials or participant totals.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which supervised office-SBP claim is selected?

Required materials and conditions: Selected claim, grade, note and measurement-setting boundaries
Conditions for verification: Material for Selected claim, grade, note and measurement-setting boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Selected claim, grade, note and measurement-setting boundaries with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N02 · What is Farah's office-SBP test across 3 arms?

Required materials and conditions: Omnibus group-by-time test, original model and denominators
Conditions for verification: Material for Omnibus group-by-time test, original model and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Omnibus group-by-time test, original model and denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N03 · Which pairwise difference does the omnibus test establish?

Required materials and conditions: Omnibus 3-arm testing versus specific adjusted comparisons
Conditions for verification: Material for Omnibus 3-arm testing versus specific adjusted comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Omnibus 3-arm testing versus specific adjusted comparisons with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N04 · Can SBP and DBP tests be combined?

Required materials and conditions: Office systolic/diastolic outcomes and precision
Conditions for verification: Material for Office systolic/diastolic outcomes and precision must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Office systolic/diastolic outcomes and precision with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N05 · Are office, central and ambulatory pressure the same outcome?

Required materials and conditions: Measurement locations, settings, devices, timing and denominators
Conditions for verification: Material for Measurement locations, settings, devices, timing and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Measurement locations, settings, devices, timing and denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N06 · Is a within-group reduction an added benefit over control?

Required materials and conditions: Within-group changes versus direct between-group effects
Conditions for verification: Material for Within-group changes versus direct between-group effects must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Within-group changes versus direct between-group effects with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N07 · Were figure/table arm-label inconsistencies resolved?

Required materials and conditions: Original figures, tables, legends and arm attribution
Conditions for verification: Material for Original figures, tables, legends and arm attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Original figures, tables, legends and arm attribution with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N08 · What were Palmeira's supportive and null results?

Required materials and conditions: Office-SBP interaction versus DBP and ambulatory pressure
Conditions for verification: Material for Office-SBP interaction versus DBP and ambulatory pressure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Office-SBP interaction versus DBP and ambulatory pressure with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N09 · Were large attrition and analysis denominators verified?

Required materials and conditions: Randomization, completion, missingness, ITT, sensitivity and time-specific denominators
Conditions for verification: Material for Randomization, completion, missingness, ITT, sensitivity and time-specific denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Randomization, completion, missingness, ITT, sensitivity and time-specific denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N10 · Can supervised results be transferred to home training?

Required materials and conditions: Training location, supervision, contact, actual exposure and adherence
Conditions for verification: Material for Training location, supervision, contact, actual exposure and adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Training location, supervision, contact, actual exposure and adherence with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N11 · Are home training and home pressure measurement the same?

Required materials and conditions: Intervention delivery location versus outcome measurement setting
Conditions for verification: Material for Intervention delivery location versus outcome measurement setting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Intervention delivery location versus outcome measurement setting with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N12 · How does null 24-hour pressure limit the office signal?

Required materials and conditions: Setting-specific tests, original values, between-group effects and denominators
Conditions for verification: Material for Setting-specific tests, original values, between-group effects and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Setting-specific tests, original values, between-group effects and denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N13 · Does office SBP establish day/night or clinical-event benefit?

Required materials and conditions: Surrogates, day/night/ambulatory pressure and long-term clinical-event boundaries
Conditions for verification: Material for Surrogates, day/night/ambulatory pressure and long-term clinical-event boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Surrogates, day/night/ambulatory pressure and long-term clinical-event boundaries with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N14 · Do signals across studies establish precise independent replication?

Required materials and conditions: Matched supervision/controls, institutions, recruitment and report/participant relationships
Conditions for verification: Material for Matched supervision/controls, institutions, recruitment and report/participant relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Matched supervision/controls, institutions, recruitment and report/participant relationships with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N15 · Who were the participants and what was their medication status?

Required materials and conditions: Diagnosis, baseline control, medication, age, comorbidities and eligibility
Conditions for verification: Material for Diagnosis, baseline control, medication, age, comorbidities and eligibility must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Diagnosis, baseline control, medication, age, comorbidities and eligibility with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N16 · Are representative training conditions instructions?

Required materials and conditions: Original intensity, exposure, delivery and actual adherence
Conditions for verification: Material for Original intensity, exposure, delivery and actual adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Original intensity, exposure, delivery and actual adherence with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N17 · Were different comparators distinguished?

Required materials and conditions: Sham, no-exercise and aerobic controls and effects of interest
Conditions for verification: Material for Sham, no-exercise and aerobic controls and effects of interest must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Sham, no-exercise and aerobic controls and effects of interest with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N18 · Were concurrent medication, activity and supervisory contact verified?

Required materials and conditions: Concurrent treatment, changes, actual exposure, measurement conditions and attribution
Conditions for verification: Material for Concurrent treatment, changes, actual exposure, measurement conditions and attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Concurrent treatment, changes, actual exposure, measurement conditions and attribution with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N19 · Were randomization, blinding, measurement and timing verified?

Required materials and conditions: Allocation, concealment, evaluators, standardized measurement, planning and missingness
Conditions for verification: Material for Allocation, concealment, evaluators, standardized measurement, planning and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Allocation, concealment, evaluators, standardized measurement, planning and missingness with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N20 · Are registration identifiers equivalent to reading original plans?

Required materials and conditions: Registration, paper linkage, changes, protocols, SAPs and planned endpoints
Conditions for verification: Material for Registration, paper linkage, changes, protocols, SAPs and planned endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Registration, paper linkage, changes, protocols, SAPs and planned endpoints with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N21 · What were funding, products, employee authors and design/analysis roles?

Required materials and conditions: Financial/device/product support, author affiliations and design/analysis/publication control
Conditions for verification: Material for Financial/device/product support, author affiliations and design/analysis/publication control must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Financial/device/product support, author affiliations and design/analysis/publication control with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N22 · Were pain, exercise pressure and vulnerable-group harms verified?

Required materials and conditions: Events, affected people, arm denominators, exposure, collection, stopping and follow-up
Conditions for verification: Material for Events, affected people, arm denominators, exposure, collection, stopping and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Events, affected people, arm denominators, exposure, collection, stopping and follow-up with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N23 · Are subclaim grades the same as parent scores and axes?

Required materials and conditions: Absent subclaim score/status/axes versus the parent verdict
Conditions for verification: Material for Absent subclaim score/status/axes versus the parent verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Absent subclaim score/status/axes versus the parent verdict with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N24 · How are representative information and both languages preserved?

Required materials and conditions: Report-specific populations, supervision, measurement settings, outcomes, timing and denominators
Conditions for verification: Material for Report-specific populations, supervision, measurement settings, outcomes, timing and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Report-specific populations, supervision, measurement settings, outcomes, timing and denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N25 · How are actual reading and report/material counts distinguished?

Required materials and conditions: Stored summaries, external reading and trial/report/cohort relationships
Conditions for verification: Material for Stored summaries, external reading and trial/report/cohort relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Stored summaries, external reading and trial/report/cohort relationships with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N26 · What are the evidence date and correction history?

Required materials and conditions: Original date, empty correction/deliberation records, production timing and original URLs
Conditions for verification: Material for Original date, empty correction/deliberation records, production timing and original URLs must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Original date, empty correction/deliberation records, production timing and original URLs with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N27 · How will new materials and changed questions be updated?

Required materials and conditions: Evidence updates, criteria revisions and original-verdict changes
Conditions for verification: Material for Evidence updates, criteria revisions and original-verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Evidence updates, criteria revisions and original-verdict changes with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

What the statuses mean

Partly verified: Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified
Unverified: Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety
Review incomplete: Awaiting user review
Met: Use only within the relevant condition's scope after user review; no automatic display in this preparation
Not reported: Distinguish only within materials actually read; do not turn unread external materials into unreported findings
Inaccessible: Not applied during this preparation because actual access was not tested
Not applicable: Use with a reason for non-applicability based on an explicit question boundary
Conflicting data: Judge after actual material comparison; review was not performed during this preparation
Insufficient evidence for the conditions: Do not use as a clinical grade encompassing currently unread materials

Change history

2026-10-18 · Public page/material version 1.0

Public pages and materials were prepared from the existing 27 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-09-07) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which supervised office-SBP claim is selected?

Current findings: The selection is lower supervised office SBP. Preserve original grade C and the note supporting direction in small trials with incomplete specific adjusted effects. Home training, home pressure and 24-hour ambulatory pressure are separate.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Supervision, comparator, timing, denominators and adjusted direct effects/CIs are unverified. Create no new independent claims or scores.
Required materials and conditions: Selected claim, grade, note and measurement-setting boundaries
Materials to obtain first: Supervision, comparator, timing, denominators and adjusted direct effects/CIs are unverified. Create no new independent claims or scores.
Further research: Material needed: Supervision, comparator, timing, denominators and adjusted direct effects/CIs are unverified. Create no new independent claims or scores. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Selected claim, grade, note and measurement-setting boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Selected claim, grade, note and measurement-setting boundaries with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N02 · What is Farah's office-SBP test across 3 arms?

Current findings: Preserve office SBP P=.041 in 72 randomized treated participants with hypertension over 12 weeks in supervised/home/no-exercise 3-arm conditions. The original text describes this as an omnibus group-by-time test.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original models, arm/time values, adjusted pairwise comparisons, denominators, direct effects/95% CIs and multiple comparisons are unverified. This P alone does not establish specific pairwise effects.
Required materials and conditions: Omnibus group-by-time test, original model and denominators
Materials to obtain first: Original models, arm/time values, adjusted pairwise comparisons, denominators, direct effects/95% CIs and multiple comparisons are unverified. This P alone does not establish specific pairwise effects.
Further research: Material needed: Original models, arm/time values, adjusted pairwise comparisons, denominators, direct effects/95% CIs and multiple comparisons are unverified. This P alone does not establish specific pairwise effects. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Omnibus group-by-time test, original model and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Omnibus group-by-time test, original model and denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N03 · Which pairwise difference does the omnibus test establish?

Current findings: P=.041 for the 3-arm/time test does not show that supervised/no-exercise, supervised/home and home/no-exercise comparisons all have the same effect or significance.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Planned comparisons, baseline adjustment, estimates/CIs, denominators, analysis populations and original tables are unverified. Do not fill in absent pairwise values, CIs or P.
Required materials and conditions: Omnibus 3-arm testing versus specific adjusted comparisons
Materials to obtain first: Planned comparisons, baseline adjustment, estimates/CIs, denominators, analysis populations and original tables are unverified. Do not fill in absent pairwise values, CIs or P.
Further research: Material needed: Planned comparisons, baseline adjustment, estimates/CIs, denominators, analysis populations and original tables are unverified. Do not fill in absent pairwise values, CIs or P. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Omnibus 3-arm testing versus specific adjusted comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Omnibus 3-arm testing versus specific adjusted comparisons with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N04 · Can SBP and DBP tests be combined?

Current findings: Farah office DBP P=.049 and SBP P=.041 are omnibus tests for different endpoints. Significant DBP also differs from a specific adjusted pairwise difference or everyday pressure benefit.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original arm values, specific comparisons, CIs, denominators, planned hierarchy and multiple testing are unverified. Do not copy DBP results into SBP effects.
Required materials and conditions: Office systolic/diastolic outcomes and precision
Materials to obtain first: Original arm values, specific comparisons, CIs, denominators, planned hierarchy and multiple testing are unverified. Do not copy DBP results into SBP effects.
Further research: Material needed: Original arm values, specific comparisons, CIs, denominators, planned hierarchy and multiple testing are unverified. Do not copy DBP results into SBP effects. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Office systolic/diastolic outcomes and precision must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Office systolic/diastolic outcomes and precision with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N05 · Are office, central and ambulatory pressure the same outcome?

Current findings: Farah covers office, central and 24-hour ambulatory pressure, and its bibliography mentions brachial/central pressure. Original P values concern office and ambulatory outcomes; exact central-pressure effects/CIs are not provided.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Locations, devices, conditions, timing, denominators, between-group comparisons/CIs and planned hierarchy are unverified. Do not estimate central values or combine all as the same SBP effect.
Required materials and conditions: Measurement locations, settings, devices, timing and denominators
Materials to obtain first: Locations, devices, conditions, timing, denominators, between-group comparisons/CIs and planned hierarchy are unverified. Do not estimate central values or combine all as the same SBP effect.
Further research: Material needed: Locations, devices, conditions, timing, denominators, between-group comparisons/CIs and planned hierarchy are unverified. Do not estimate central values or combine all as the same SBP effect. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Measurement locations, settings, devices, timing and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Measurement locations, settings, devices, timing and denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N06 · Is a within-group reduction an added benefit over control?

Current findings: The original text does not turn within-group reductions into specific between-group effects. Distinguish directional supervised office signals from baseline/follow-up changes.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Baseline/follow-up values, adjusted models, specific comparisons, arm denominators and original effects/CIs are unverified. Do not subtract changes to create new control-relative effects.
Required materials and conditions: Within-group changes versus direct between-group effects
Materials to obtain first: Baseline/follow-up values, adjusted models, specific comparisons, arm denominators and original effects/CIs are unverified. Do not subtract changes to create new control-relative effects.
Further research: Material needed: Baseline/follow-up values, adjusted models, specific comparisons, arm denominators and original effects/CIs are unverified. Do not subtract changes to create new control-relative effects. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Within-group changes versus direct between-group effects must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Within-group changes versus direct between-group effects with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N07 · Were figure/table arm-label inconsistencies resolved?

Current findings: Original explanations and bibliographic notes identify figure/table arm-label inconsistencies. Do not arbitrarily assign numbers to arms and read them as specific pairwise effects.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Complete original figures/tables, legends, arm keys, underlying data, explanations and corrections are needed. Production did not resolve these inconsistencies or edit values.
Required materials and conditions: Original figures, tables, legends and arm attribution
Materials to obtain first: Complete original figures/tables, legends, arm keys, underlying data, explanations and corrections are needed. Production did not resolve these inconsistencies or edit values.
Further research: Material needed: Complete original figures/tables, legends, arm keys, underlying data, explanations and corrections are needed. Production did not resolve these inconsistencies or edit values. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original figures, tables, legends and arm attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original figures, tables, legends and arm attribution with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N08 · What were Palmeira's supportive and null results?

Current findings: Palmeira is preserved as a 63-participant, 12-week randomized trial with positive office-SBP interaction and null DBP/ambulatory pressure. Exact SBP effects/CIs, P and arm denominators are absent from the summary.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original models, arm denominators, baseline/follow-up, endpoint comparisons/CIs and planned analyses are unverified. Do not copy Farah P into this report.
Required materials and conditions: Office-SBP interaction versus DBP and ambulatory pressure
Materials to obtain first: Original models, arm denominators, baseline/follow-up, endpoint comparisons/CIs and planned analyses are unverified. Do not copy Farah P into this report.
Further research: Material needed: Original models, arm denominators, baseline/follow-up, endpoint comparisons/CIs and planned analyses are unverified. Do not copy Farah P into this report. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Office-SBP interaction versus DBP and ambulatory pressure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Office-SBP interaction versus DBP and ambulatory pressure with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02

N09 · Were large attrition and analysis denominators verified?

Current findings: Palmeira bibliography records 63 participants and large attrition. Exact completion/analysis counts, arm imbalances and missing-data handling are absent from the summary. Do not treat all participants as completers for every endpoint.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original flow charts, arm allocation/completion, missingness/withdrawal reasons, ITT, analyses, sensitivity and time-specific denominators are unverified. Calculate no new withdrawal counts, rates or effects.
Required materials and conditions: Randomization, completion, missingness, ITT, sensitivity and time-specific denominators
Materials to obtain first: Original flow charts, arm allocation/completion, missingness/withdrawal reasons, ITT, analyses, sensitivity and time-specific denominators are unverified. Calculate no new withdrawal counts, rates or effects.
Further research: Material needed: Original flow charts, arm allocation/completion, missingness/withdrawal reasons, ITT, analyses, sensitivity and time-specific denominators are unverified. Calculate no new withdrawal counts, rates or effects. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Randomization, completion, missingness, ITT, sensitivity and time-specific denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Randomization, completion, missingness, ITT, sensitivity and time-specific denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02

N10 · Can supervised results be transferred to home training?

Current findings: The original text does not transfer supervised results to unsupervised home training. Distinguish Farah 3-arm conditions from null results in the 2024 home-training report with 84 participants.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Actual intensity, exposure, contact, adherence, comparators and original comparisons/denominators are unverified. Do not equate supervised/home conditions or create new exercise methods.
Required materials and conditions: Training location, supervision, contact, actual exposure and adherence
Materials to obtain first: Actual intensity, exposure, contact, adherence, comparators and original comparisons/denominators are unverified. Do not equate supervised/home conditions or create new exercise methods.
Further research: Material needed: Actual intensity, exposure, contact, adherence, comparators and original comparisons/denominators are unverified. Do not equate supervised/home conditions or create new exercise methods. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Training location, supervision, contact, actual exposure and adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Training location, supervision, contact, actual exposure and adherence with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R03

N11 · Are home training and home pressure measurement the same?

Current findings: The original text distinguishes home-training conditions from office, home and 24-hour measurements. Training at home does not establish a comparison using home-pressure values.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original data separating training location/supervision from measurement location, devices, schedules, denominators, timing and specific comparisons are needed. Exact home-pressure effects are absent from the summary.
Required materials and conditions: Intervention delivery location versus outcome measurement setting
Materials to obtain first: Original data separating training location/supervision from measurement location, devices, schedules, denominators, timing and specific comparisons are needed. Exact home-pressure effects are absent from the summary.
Further research: Material needed: Original data separating training location/supervision from measurement location, devices, schedules, denominators, timing and specific comparisons are needed. Exact home-pressure effects are absent from the summary. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Intervention delivery location versus outcome measurement setting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Intervention delivery location versus outcome measurement setting with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N12 · How does null 24-hour pressure limit the office signal?

Current findings: In the same Farah trial, 24-hour ambulatory SBP P=.650 and DBP P=.340 are null. Do not extend office signals into all-day pressure reduction.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Setting-specific original values, between-group CIs, denominators, devices, valid measurements, timing and effects of interest are unverified. Null does not certify exact effect 0 or equivalence.
Required materials and conditions: Setting-specific tests, original values, between-group effects and denominators
Materials to obtain first: Setting-specific original values, between-group CIs, denominators, devices, valid measurements, timing and effects of interest are unverified. Null does not certify exact effect 0 or equivalence.
Further research: Material needed: Setting-specific original values, between-group CIs, denominators, devices, valid measurements, timing and effects of interest are unverified. Null does not certify exact effect 0 or equivalence. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Setting-specific tests, original values, between-group effects and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Setting-specific tests, original values, between-group effects and denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N13 · Does office SBP establish day/night or clinical-event benefit?

Current findings: The original text limits conclusions by measurement setting and surrogate outcomes; office results do not establish everyday pressure benefit or medication replacement. Direct day/night or disease-event effects/CIs are absent.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Day/night definitions, measurements/denominators, between-group effects/CIs, clinical importance and direct long-term event data are needed. Create no new medication reduction/replacement or treatment instructions.
Required materials and conditions: Surrogates, day/night/ambulatory pressure and long-term clinical-event boundaries
Materials to obtain first: Day/night definitions, measurements/denominators, between-group effects/CIs, clinical importance and direct long-term event data are needed. Create no new medication reduction/replacement or treatment instructions.
Further research: Material needed: Day/night definitions, measurements/denominators, between-group effects/CIs, clinical importance and direct long-term event data are needed. Create no new medication reduction/replacement or treatment instructions. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Surrogates, day/night/ambulatory pressure and long-term clinical-event boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Surrogates, day/night/ambulatory pressure and long-term clinical-event boundaries with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N14 · Do signals across studies establish precise independent replication?

Current findings: The original text describes supervised office-SBP signals across trials as a strength. Preserve original I2/R1 axes without upgrading directions from different controls, within-group changes or omnibus tests into new independent confirmation.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Institutions, recruitment/registration, support, report/participant overlap, matched supervision/controls and original effects/CIs are unverified. Do not fill in unique-trial/participant totals.
Required materials and conditions: Matched supervision/controls, institutions, recruitment and report/participant relationships
Materials to obtain first: Institutions, recruitment/registration, support, report/participant overlap, matched supervision/controls and original effects/CIs are unverified. Do not fill in unique-trial/participant totals.
Further research: Material needed: Institutions, recruitment/registration, support, report/participant overlap, matched supervision/controls and original effects/CIs are unverified. Do not fill in unique-trial/participant totals. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Matched supervision/controls, institutions, recruitment and report/participant relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Matched supervision/controls, institutions, recruitment and report/participant relationships with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N15 · Who were the participants and what was their medication status?

Current findings: Farah randomized 72 treated participants with hypertension; Palmeira concerns primary-care hypertension; the 2024 report concerns older home-training participants. Original counts and representative information do not establish identical populations.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Diagnosis, baseline control, medication/changes, age, comorbidities, recruitment/exclusions and arm denominators are unverified. Do not extend this to untreated, other-patient or vulnerable populations.
Required materials and conditions: Diagnosis, baseline control, medication, age, comorbidities and eligibility
Materials to obtain first: Diagnosis, baseline control, medication/changes, age, comorbidities, recruitment/exclusions and arm denominators are unverified. Do not extend this to untreated, other-patient or vulnerable populations.
Further research: Material needed: Diagnosis, baseline control, medication/changes, age, comorbidities, recruitment/exclusions and arm denominators are unverified. Do not extend this to untreated, other-patient or vulnerable populations. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Diagnosis, baseline control, medication, age, comorbidities and eligibility must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Diagnosis, baseline control, medication, age, comorbidities and eligibility with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N16 · Are representative training conditions instructions?

Current findings: Original representative conditions are 30% MVC, 4 holds of 2 minutes, 3 times weekly. Preserve them as study identifiers; actual intensity and adherence are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original devices, intensity measurement, exposure/sessions, supervision/contact, adherence and control records are needed. Calculate no new total time/exposure or exercise, breathing or treatment steps.
Required materials and conditions: Original intensity, exposure, delivery and actual adherence
Materials to obtain first: Original devices, intensity measurement, exposure/sessions, supervision/contact, adherence and control records are needed. Calculate no new total time/exposure or exercise, breathing or treatment steps.
Further research: Material needed: Original devices, intensity measurement, exposure/sessions, supervision/contact, adherence and control records are needed. Calculate no new total time/exposure or exercise, breathing or treatment steps. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original intensity, exposure, delivery and actual adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original intensity, exposure, delivery and actual adherence with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N17 · Were different comparators distinguished?

Current findings: The original text distinguishes trials of supervised/home training with 5% MVC sham, no-exercise and aerobic controls. Do not fill in the same comparator/blinding conditions for all reports.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Report-specific control intensity, exposure, contact, baseline adjustment, planned comparisons and denominators are unverified. Do not interchange comparator-specific effects.
Required materials and conditions: Sham, no-exercise and aerobic controls and effects of interest
Materials to obtain first: Report-specific control intensity, exposure, contact, baseline adjustment, planned comparisons and denominators are unverified. Do not interchange comparator-specific effects.
Further research: Material needed: Report-specific control intensity, exposure, contact, baseline adjustment, planned comparisons and denominators are unverified. Do not interchange comparator-specific effects. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Sham, no-exercise and aerobic controls and effects of interest must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Sham, no-exercise and aerobic controls and effects of interest with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N18 · Were concurrent medication, activity and supervisory contact verified?

Current findings: The original text records treated participants and supervised/home conditions. Medication types, doses, changes, baseline activity, premeasurement conditions, contact and actual exposure details are absent.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm medication/changes, concurrent activity, adherence, measurement conditions, models, denominators and original effects are needed. Do not establish identical conditions or effects without medication.
Required materials and conditions: Concurrent treatment, changes, actual exposure, measurement conditions and attribution
Materials to obtain first: Arm medication/changes, concurrent activity, adherence, measurement conditions, models, denominators and original effects are needed. Do not establish identical conditions or effects without medication.
Further research: Material needed: Arm medication/changes, concurrent activity, adherence, measurement conditions, models, denominators and original effects are needed. Do not establish identical conditions or effects without medication. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Concurrent treatment, changes, actual exposure, measurement conditions and attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Concurrent treatment, changes, actual exposure, measurement conditions and attribution with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N19 · Were randomization, blinding, measurement and timing verified?

Current findings: Original evidence labels randomized trials, but allocation, concealment, evaluators, standardized measurement, prospective planning, multiple time points and detailed attrition are absent from summaries. Preserve original B2 and small-sample/attrition limitations.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original methods, measurement procedures, blinding, baseline adjustment/missingness, planned endpoints/comparisons/timing and analysis plans are needed. Create no official method-assessment pass or new grade.
Required materials and conditions: Allocation, concealment, evaluators, standardized measurement, planning and missingness
Materials to obtain first: Original methods, measurement procedures, blinding, baseline adjustment/missingness, planned endpoints/comparisons/timing and analysis plans are needed. Create no official method-assessment pass or new grade.
Further research: Material needed: Original methods, measurement procedures, blinding, baseline adjustment/missingness, planned endpoints/comparisons/timing and analysis plans are needed. Create no official method-assessment pass or new grade. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Allocation, concealment, evaluators, standardized measurement, planning and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Allocation, concealment, evaluators, standardized measurement, planning and missingness with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N20 · Are registration identifiers equivalent to reading original plans?

Current findings: Farah NCT02348138 and Palmeira NCT03216317 are original identifiers; registration for the 2024 report is unverified. PMCID is preserved in the bibliography; external registration, plans, full texts and prospective-status comparisons were unread this run.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original registration, changes, paper linkage, protocols/SAPs, planned endpoints, arm comparisons and denominators are needed. Identifiers, URLs and PMCID alone do not establish reading or prospective verification.
Required materials and conditions: Registration, paper linkage, changes, protocols, SAPs and planned endpoints
Materials to obtain first: Original registration, changes, paper linkage, protocols/SAPs, planned endpoints, arm comparisons and denominators are needed. Identifiers, URLs and PMCID alone do not establish reading or prospective verification.
Further research: Material needed: Original registration, changes, paper linkage, protocols/SAPs, planned endpoints, arm comparisons and denominators are needed. Identifiers, URLs and PMCID alone do not establish reading or prospective verification. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Registration, paper linkage, changes, protocols, SAPs and planned endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Registration, paper linkage, changes, protocols, SAPs and planned endpoints with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N21 · What were funding, products, employee authors and design/analysis roles?

Current findings: Preserve Farah public/academic support, Palmeira public primary-care support and the 2024 report's academic support. Public/academic wording or parent I2 does not become new certification of overall independence.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Disclosures of financial/device/product support, company/author affiliations, design/analysis/publication roles and institutional, recruitment and report relationships are unread. Do not fill in no support or involvement.
Required materials and conditions: Financial/device/product support, author affiliations and design/analysis/publication control
Materials to obtain first: Disclosures of financial/device/product support, company/author affiliations, design/analysis/publication roles and institutional, recruitment and report relationships are unread. Do not fill in no support or involvement.
Further research: Material needed: Disclosures of financial/device/product support, company/author affiliations, design/analysis/publication roles and institutional, recruitment and report relationships are unread. Do not fill in no support or involvement. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Financial/device/product support, author affiliations and design/analysis/publication control must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Financial/device/product support, author affiliations and design/analysis/publication control with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N22 · Were pain, exercise pressure and vulnerable-group harms verified?

Current findings: Original safety text records hand/arm pain, pressure rises during breath-holding/Valsalva and uncontrolled-hypertension/cardiovascular-disease boundaries. Trial-specific harm events, exposure, denominators and collection are absent from summaries.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Harm collection, severity/timing, events/affected people, denominators, actual exposure, stopping, medication/vulnerable groups and long-term data are needed. Null ambulatory pressure does not become no harm or safety certification.
Required materials and conditions: Events, affected people, arm denominators, exposure, collection, stopping and follow-up
Materials to obtain first: Harm collection, severity/timing, events/affected people, denominators, actual exposure, stopping, medication/vulnerable groups and long-term data are needed. Null ambulatory pressure does not become no harm or safety certification.
Further research: Material needed: Harm collection, severity/timing, events/affected people, denominators, actual exposure, stopping, medication/vulnerable groups and long-term data are needed. Null ambulatory pressure does not become no harm or safety certification. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Events, affected people, arm denominators, exposure, collection, stopping and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Events, affected people, arm denominators, exposure, collection, stopping and follow-up with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N23 · Are subclaim grades the same as parent scores and axes?

Current findings: Supervised office subclaim C and ambulatory subclaim D have no individual score, status or axes. Preserve parent C with 50 points, caution, B/S/R1/I2/EX/B2 and unrecorded precision as parent context.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Do not fill subclaims with parent scores/axes or turn unrecorded precision into default values, new scores or independence certification. Distinguish parent/subclaim application boundaries.
Required materials and conditions: Absent subclaim score/status/axes versus the parent verdict
Materials to obtain first: Do not fill subclaims with parent scores/axes or turn unrecorded precision into default values, new scores or independence certification. Distinguish parent/subclaim application boundaries.
Further research: Material needed: Do not fill subclaims with parent scores/axes or turn unrecorded precision into default values, new scores or independence certification. Distinguish parent/subclaim application boundaries. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Absent subclaim score/status/axes versus the parent verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Absent subclaim score/status/axes versus the parent verdict with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N24 · How are representative information and both languages preserved?

Current findings: Preserve complete bilingual texts and representative information. Representative 72 participants, 12 weeks, no exercise and office/central/ambulatory labels do not automatically apply to 63 or 84 participants, all day/night/home outcomes or each arm.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Report-specific delivery, supervision, measurement settings, endpoints, timing, denominators and original English comparison materials are needed. No external English comparison or correction review was performed this run.
Required materials and conditions: Report-specific populations, supervision, measurement settings, outcomes, timing and denominators
Materials to obtain first: Report-specific delivery, supervision, measurement settings, endpoints, timing, denominators and original English comparison materials are needed. No external English comparison or correction review was performed this run.
Further research: Material needed: Report-specific delivery, supervision, measurement settings, endpoints, timing, denominators and original English comparison materials are needed. No external English comparison or correction review was performed this run. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Report-specific populations, supervision, measurement settings, outcomes, timing and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Report-specific populations, supervision, measurement settings, outcomes, timing and denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N25 · How are actual reading and report/material counts distinguished?

Current findings: The complete parent JSON was read for production. Historical verification, separation and cross-checks remain historical records; external materials are unread. Report/material counts do not count acquired papers, independent trials, participants or quality scores.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original-material acquisition, actual reading and trial/report/cohort relationships are unverified. URLs/identifiers alone do not establish completed reading or unique-trial/participant totals.
Required materials and conditions: Stored summaries, external reading and trial/report/cohort relationships
Materials to obtain first: Original-material acquisition, actual reading and trial/report/cohort relationships are unverified. URLs/identifiers alone do not establish completed reading or unique-trial/participant totals.
Further research: Material needed: Original-material acquisition, actual reading and trial/report/cohort relationships are unverified. URLs/identifiers alone do not establish completed reading or unique-trial/participant totals. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Stored summaries, external reading and trial/report/cohort relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Stored summaries, external reading and trial/report/cohort relationships with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N26 · What are the evidence date and correction history?

Current findings: Preserve original evidence date 2026-09-07 and empty correction/deliberation records. Figure/table inconsistencies do not justify inventing corrections or turning production dates into evidence-verification dates.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: When originals/corrections are acquired, preserve and link complete texts, events, versions and reasons. No original-verdict change or external lookup was performed this run.
Required materials and conditions: Original date, empty correction/deliberation records, production timing and original URLs
Materials to obtain first: When originals/corrections are acquired, preserve and link complete texts, events, versions and reasons. No original-verdict change or external lookup was performed this run.
Further research: Material needed: When originals/corrections are acquired, preserve and link complete texts, events, versions and reasons. No original-verdict change or external lookup was performed this run. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original date, empty correction/deliberation records, production timing and original URLs must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original date, empty correction/deliberation records, production timing and original URLs with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N27 · How will new materials and changed questions be updated?

Current findings: Preserve original materials, conditions and observations. New materials are linked to supervision/controls, measurement settings, denominators, endpoints/timing/day-night, related reports and subclaim scope; no new lookup or reassessment occurred this run.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Updates must retain complete texts, criteria versions, events and reasons. Do not invent clinical calculations, effects/CIs, independence certification, exercise methods, pressure-medication reduction/replacement or treatment instructions.
Required materials and conditions: Evidence updates, criteria revisions and original-verdict changes
Materials to obtain first: Updates must retain complete texts, criteria versions, events and reasons. Do not invent clinical calculations, effects/CIs, independence certification, exercise methods, pressure-medication reduction/replacement or treatment instructions.
Further research: Material needed: Updates must retain complete texts, criteria versions, events and reasons. Do not invent clinical calculations, effects/CIs, independence certification, exercise methods, pressure-medication reduction/replacement or treatment instructions. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Evidence updates, criteria revisions and original-verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Evidence updates, criteria revisions and original-verdict changes with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03