# 30% MVC handgrip × supervised office SBP: evidence checklist

Verdict 3002 · Evidence Check

Stored-material review date: Not recorded  
Original evidence cut-off: 2026-09-07  
Review-criteria version: 1.0  
Public page/material preparation date: 2026-10-18

Clinical papers were not read directly; existing review summaries were checked. No new clinical-literature search was performed. Unverified does not mean that research is absent or that there is no effect.

## Assessment scope

- Population: Farah randomized 72 treated participants with hypertension; Palmeira has 63 primary-care participants with hypertension; the 2024 report has 84 older home-training participants. Arm eligibility, baseline control, medication changes, comorbidities and outcome-specific analysis denominators are unverified. Do not add these different participant counts.
- Ingredient, formulation and route: Isometric handgrip training referenced to maximal voluntary contraction (MVC). Distinguish supervised delivery from unsupervised home training. Supervisory contact, actual intensity, devices, adherence and component contributions are unverified. Do not transfer supervised results to home training.
- Dose: Original representative study conditions are 30% MVC, 4 holds of 2 minutes, 3 times weekly. Actual exposure, adherence and discontinuation are unverified. Calculate no new total time/exposure and do not turn these into personal exercise/breathing procedures, medication reduction/replacement or treatment instructions.
- Comparator: Distinguish Farah supervised, home and no-exercise 3-arm conditions. Original 5% MVC sham, no-exercise and aerobic controls concern different trial contexts; do not fill in the same comparator for every report. Arm contact, exposure, medication/lifestyle care and adjusted effects for specific comparisons are unverified.
- Measured outcome: The selection is supervised office SBP. Farah office SBP P=.041 and DBP P=.049 are omnibus 3-arm group-by-time tests; a specific adjusted pairwise effect/95% CI is unverified. Distinguish the same trial's null 24-hour ambulatory SBP P=.650/DBP P=.340 and office, central and home measurements.
- Duration: Key Farah and Palmeira trials span 12 weeks. Exact duration of 2024 home training, detailed outcome timing, post-training persistence, long-term harms and clinical events are unverified. Do not turn a 24-hour measurement window into training duration or all-day benefit.
- Questions outside this scope: Turning a 3-arm omnibus test or within-group reduction into a specific adjusted pairwise effect/CI; Combining office SBP/DBP, central, home, 24-hour and day/night results into one effect; Extending supervised signals into unsupervised home training, all-day pressure reduction or medication replacement; Turning null results into exact effect 0, equivalence or safety certification; Arbitrarily resolving figure/table arm-label inconsistencies or creating new numbers, CIs or totals; Using shared reports/participants, academic support or parent C with 50 points as new independence, precision or subclaim scores; Creating new exercise methods, breathing procedures, medication reduction/replacement or treatment instructions

## Checklist items

### N01 · Which supervised office-SBP claim is selected?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The selection is lower supervised office SBP. Preserve original grade C and the note supporting direction in small trials with incomplete specific adjusted effects. Home training, home pressure and 24-hour ambulatory pressure are separate.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Supervision, comparator, timing, denominators and adjusted direct effects/CIs are unverified. Create no new independent claims or scores.
- Required materials and conditions: Selected claim, grade, note and measurement-setting boundaries
- Materials to obtain first: Supervision, comparator, timing, denominators and adjusted direct effects/CIs are unverified. Create no new independent claims or scores.
- Further research: Material needed: Supervision, comparator, timing, denominators and adjusted direct effects/CIs are unverified. Create no new independent claims or scores. This records needed materials; no new research was executed.
- Conditions for verification: Material for Selected claim, grade, note and measurement-setting boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Selected claim, grade, note and measurement-setting boundaries with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N02 · What is Farah's office-SBP test across 3 arms?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Preserve office SBP P=.041 in 72 randomized treated participants with hypertension over 12 weeks in supervised/home/no-exercise 3-arm conditions. The original text describes this as an omnibus group-by-time test.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Original models, arm/time values, adjusted pairwise comparisons, denominators, direct effects/95% CIs and multiple comparisons are unverified. This P alone does not establish specific pairwise effects.
- Required materials and conditions: Omnibus group-by-time test, original model and denominators
- Materials to obtain first: Original models, arm/time values, adjusted pairwise comparisons, denominators, direct effects/95% CIs and multiple comparisons are unverified. This P alone does not establish specific pairwise effects.
- Further research: Material needed: Original models, arm/time values, adjusted pairwise comparisons, denominators, direct effects/95% CIs and multiple comparisons are unverified. This P alone does not establish specific pairwise effects. This records needed materials; no new research was executed.
- Conditions for verification: Material for Omnibus group-by-time test, original model and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Omnibus group-by-time test, original model and denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01

### N03 · Which pairwise difference does the omnibus test establish?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: P=.041 for the 3-arm/time test does not show that supervised/no-exercise, supervised/home and home/no-exercise comparisons all have the same effect or significance.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Planned comparisons, baseline adjustment, estimates/CIs, denominators, analysis populations and original tables are unverified. Do not fill in absent pairwise values, CIs or P.
- Required materials and conditions: Omnibus 3-arm testing versus specific adjusted comparisons
- Materials to obtain first: Planned comparisons, baseline adjustment, estimates/CIs, denominators, analysis populations and original tables are unverified. Do not fill in absent pairwise values, CIs or P.
- Further research: Material needed: Planned comparisons, baseline adjustment, estimates/CIs, denominators, analysis populations and original tables are unverified. Do not fill in absent pairwise values, CIs or P. This records needed materials; no new research was executed.
- Conditions for verification: Material for Omnibus 3-arm testing versus specific adjusted comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Omnibus 3-arm testing versus specific adjusted comparisons with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01

### N04 · Can SBP and DBP tests be combined?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Farah office DBP P=.049 and SBP P=.041 are omnibus tests for different endpoints. Significant DBP also differs from a specific adjusted pairwise difference or everyday pressure benefit.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Original arm values, specific comparisons, CIs, denominators, planned hierarchy and multiple testing are unverified. Do not copy DBP results into SBP effects.
- Required materials and conditions: Office systolic/diastolic outcomes and precision
- Materials to obtain first: Original arm values, specific comparisons, CIs, denominators, planned hierarchy and multiple testing are unverified. Do not copy DBP results into SBP effects.
- Further research: Material needed: Original arm values, specific comparisons, CIs, denominators, planned hierarchy and multiple testing are unverified. Do not copy DBP results into SBP effects. This records needed materials; no new research was executed.
- Conditions for verification: Material for Office systolic/diastolic outcomes and precision must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Office systolic/diastolic outcomes and precision with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01

### N05 · Are office, central and ambulatory pressure the same outcome?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Farah covers office, central and 24-hour ambulatory pressure, and its bibliography mentions brachial/central pressure. Original P values concern office and ambulatory outcomes; exact central-pressure effects/CIs are not provided.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Locations, devices, conditions, timing, denominators, between-group comparisons/CIs and planned hierarchy are unverified. Do not estimate central values or combine all as the same SBP effect.
- Required materials and conditions: Measurement locations, settings, devices, timing and denominators
- Materials to obtain first: Locations, devices, conditions, timing, denominators, between-group comparisons/CIs and planned hierarchy are unverified. Do not estimate central values or combine all as the same SBP effect.
- Further research: Material needed: Locations, devices, conditions, timing, denominators, between-group comparisons/CIs and planned hierarchy are unverified. Do not estimate central values or combine all as the same SBP effect. This records needed materials; no new research was executed.
- Conditions for verification: Material for Measurement locations, settings, devices, timing and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Measurement locations, settings, devices, timing and denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01

### N06 · Is a within-group reduction an added benefit over control?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original text does not turn within-group reductions into specific between-group effects. Distinguish directional supervised office signals from baseline/follow-up changes.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Baseline/follow-up values, adjusted models, specific comparisons, arm denominators and original effects/CIs are unverified. Do not subtract changes to create new control-relative effects.
- Required materials and conditions: Within-group changes versus direct between-group effects
- Materials to obtain first: Baseline/follow-up values, adjusted models, specific comparisons, arm denominators and original effects/CIs are unverified. Do not subtract changes to create new control-relative effects.
- Further research: Material needed: Baseline/follow-up values, adjusted models, specific comparisons, arm denominators and original effects/CIs are unverified. Do not subtract changes to create new control-relative effects. This records needed materials; no new research was executed.
- Conditions for verification: Material for Within-group changes versus direct between-group effects must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Within-group changes versus direct between-group effects with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N07 · Were figure/table arm-label inconsistencies resolved?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Original explanations and bibliographic notes identify figure/table arm-label inconsistencies. Do not arbitrarily assign numbers to arms and read them as specific pairwise effects.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Complete original figures/tables, legends, arm keys, underlying data, explanations and corrections are needed. Production did not resolve these inconsistencies or edit values.
- Required materials and conditions: Original figures, tables, legends and arm attribution
- Materials to obtain first: Complete original figures/tables, legends, arm keys, underlying data, explanations and corrections are needed. Production did not resolve these inconsistencies or edit values.
- Further research: Material needed: Complete original figures/tables, legends, arm keys, underlying data, explanations and corrections are needed. Production did not resolve these inconsistencies or edit values. This records needed materials; no new research was executed.
- Conditions for verification: Material for Original figures, tables, legends and arm attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Original figures, tables, legends and arm attribution with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01

### N08 · What were Palmeira's supportive and null results?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Palmeira is preserved as a 63-participant, 12-week randomized trial with positive office-SBP interaction and null DBP/ambulatory pressure. Exact SBP effects/CIs, P and arm denominators are absent from the summary.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Original models, arm denominators, baseline/follow-up, endpoint comparisons/CIs and planned analyses are unverified. Do not copy Farah P into this report.
- Required materials and conditions: Office-SBP interaction versus DBP and ambulatory pressure
- Materials to obtain first: Original models, arm denominators, baseline/follow-up, endpoint comparisons/CIs and planned analyses are unverified. Do not copy Farah P into this report.
- Further research: Material needed: Original models, arm denominators, baseline/follow-up, endpoint comparisons/CIs and planned analyses are unverified. Do not copy Farah P into this report. This records needed materials; no new research was executed.
- Conditions for verification: Material for Office-SBP interaction versus DBP and ambulatory pressure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Office-SBP interaction versus DBP and ambulatory pressure with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R02

### N09 · Were large attrition and analysis denominators verified?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Palmeira bibliography records 63 participants and large attrition. Exact completion/analysis counts, arm imbalances and missing-data handling are absent from the summary. Do not treat all participants as completers for every endpoint.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Original flow charts, arm allocation/completion, missingness/withdrawal reasons, ITT, analyses, sensitivity and time-specific denominators are unverified. Calculate no new withdrawal counts, rates or effects.
- Required materials and conditions: Randomization, completion, missingness, ITT, sensitivity and time-specific denominators
- Materials to obtain first: Original flow charts, arm allocation/completion, missingness/withdrawal reasons, ITT, analyses, sensitivity and time-specific denominators are unverified. Calculate no new withdrawal counts, rates or effects.
- Further research: Material needed: Original flow charts, arm allocation/completion, missingness/withdrawal reasons, ITT, analyses, sensitivity and time-specific denominators are unverified. Calculate no new withdrawal counts, rates or effects. This records needed materials; no new research was executed.
- Conditions for verification: Material for Randomization, completion, missingness, ITT, sensitivity and time-specific denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Randomization, completion, missingness, ITT, sensitivity and time-specific denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R02

### N10 · Can supervised results be transferred to home training?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original text does not transfer supervised results to unsupervised home training. Distinguish Farah 3-arm conditions from null results in the 2024 home-training report with 84 participants.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Actual intensity, exposure, contact, adherence, comparators and original comparisons/denominators are unverified. Do not equate supervised/home conditions or create new exercise methods.
- Required materials and conditions: Training location, supervision, contact, actual exposure and adherence
- Materials to obtain first: Actual intensity, exposure, contact, adherence, comparators and original comparisons/denominators are unverified. Do not equate supervised/home conditions or create new exercise methods.
- Further research: Material needed: Actual intensity, exposure, contact, adherence, comparators and original comparisons/denominators are unverified. Do not equate supervised/home conditions or create new exercise methods. This records needed materials; no new research was executed.
- Conditions for verification: Material for Training location, supervision, contact, actual exposure and adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Training location, supervision, contact, actual exposure and adherence with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R03

### N11 · Are home training and home pressure measurement the same?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original text distinguishes home-training conditions from office, home and 24-hour measurements. Training at home does not establish a comparison using home-pressure values.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Original data separating training location/supervision from measurement location, devices, schedules, denominators, timing and specific comparisons are needed. Exact home-pressure effects are absent from the summary.
- Required materials and conditions: Intervention delivery location versus outcome measurement setting
- Materials to obtain first: Original data separating training location/supervision from measurement location, devices, schedules, denominators, timing and specific comparisons are needed. Exact home-pressure effects are absent from the summary.
- Further research: Material needed: Original data separating training location/supervision from measurement location, devices, schedules, denominators, timing and specific comparisons are needed. Exact home-pressure effects are absent from the summary. This records needed materials; no new research was executed.
- Conditions for verification: Material for Intervention delivery location versus outcome measurement setting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Intervention delivery location versus outcome measurement setting with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N12 · How does null 24-hour pressure limit the office signal?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: In the same Farah trial, 24-hour ambulatory SBP P=.650 and DBP P=.340 are null. Do not extend office signals into all-day pressure reduction.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Setting-specific original values, between-group CIs, denominators, devices, valid measurements, timing and effects of interest are unverified. Null does not certify exact effect 0 or equivalence.
- Required materials and conditions: Setting-specific tests, original values, between-group effects and denominators
- Materials to obtain first: Setting-specific original values, between-group CIs, denominators, devices, valid measurements, timing and effects of interest are unverified. Null does not certify exact effect 0 or equivalence.
- Further research: Material needed: Setting-specific original values, between-group CIs, denominators, devices, valid measurements, timing and effects of interest are unverified. Null does not certify exact effect 0 or equivalence. This records needed materials; no new research was executed.
- Conditions for verification: Material for Setting-specific tests, original values, between-group effects and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Setting-specific tests, original values, between-group effects and denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N13 · Does office SBP establish day/night or clinical-event benefit?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original text limits conclusions by measurement setting and surrogate outcomes; office results do not establish everyday pressure benefit or medication replacement. Direct day/night or disease-event effects/CIs are absent.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Day/night definitions, measurements/denominators, between-group effects/CIs, clinical importance and direct long-term event data are needed. Create no new medication reduction/replacement or treatment instructions.
- Required materials and conditions: Surrogates, day/night/ambulatory pressure and long-term clinical-event boundaries
- Materials to obtain first: Day/night definitions, measurements/denominators, between-group effects/CIs, clinical importance and direct long-term event data are needed. Create no new medication reduction/replacement or treatment instructions.
- Further research: Material needed: Day/night definitions, measurements/denominators, between-group effects/CIs, clinical importance and direct long-term event data are needed. Create no new medication reduction/replacement or treatment instructions. This records needed materials; no new research was executed.
- Conditions for verification: Material for Surrogates, day/night/ambulatory pressure and long-term clinical-event boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Surrogates, day/night/ambulatory pressure and long-term clinical-event boundaries with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N14 · Do signals across studies establish precise independent replication?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original text describes supervised office-SBP signals across trials as a strength. Preserve original I2/R1 axes without upgrading directions from different controls, within-group changes or omnibus tests into new independent confirmation.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Institutions, recruitment/registration, support, report/participant overlap, matched supervision/controls and original effects/CIs are unverified. Do not fill in unique-trial/participant totals.
- Required materials and conditions: Matched supervision/controls, institutions, recruitment and report/participant relationships
- Materials to obtain first: Institutions, recruitment/registration, support, report/participant overlap, matched supervision/controls and original effects/CIs are unverified. Do not fill in unique-trial/participant totals.
- Further research: Material needed: Institutions, recruitment/registration, support, report/participant overlap, matched supervision/controls and original effects/CIs are unverified. Do not fill in unique-trial/participant totals. This records needed materials; no new research was executed.
- Conditions for verification: Material for Matched supervision/controls, institutions, recruitment and report/participant relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Matched supervision/controls, institutions, recruitment and report/participant relationships with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N15 · Who were the participants and what was their medication status?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Farah randomized 72 treated participants with hypertension; Palmeira concerns primary-care hypertension; the 2024 report concerns older home-training participants. Original counts and representative information do not establish identical populations.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Diagnosis, baseline control, medication/changes, age, comorbidities, recruitment/exclusions and arm denominators are unverified. Do not extend this to untreated, other-patient or vulnerable populations.
- Required materials and conditions: Diagnosis, baseline control, medication, age, comorbidities and eligibility
- Materials to obtain first: Diagnosis, baseline control, medication/changes, age, comorbidities, recruitment/exclusions and arm denominators are unverified. Do not extend this to untreated, other-patient or vulnerable populations.
- Further research: Material needed: Diagnosis, baseline control, medication/changes, age, comorbidities, recruitment/exclusions and arm denominators are unverified. Do not extend this to untreated, other-patient or vulnerable populations. This records needed materials; no new research was executed.
- Conditions for verification: Material for Diagnosis, baseline control, medication, age, comorbidities and eligibility must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Diagnosis, baseline control, medication, age, comorbidities and eligibility with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N16 · Are representative training conditions instructions?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Original representative conditions are 30% MVC, 4 holds of 2 minutes, 3 times weekly. Preserve them as study identifiers; actual intensity and adherence are unverified.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Original devices, intensity measurement, exposure/sessions, supervision/contact, adherence and control records are needed. Calculate no new total time/exposure or exercise, breathing or treatment steps.
- Required materials and conditions: Original intensity, exposure, delivery and actual adherence
- Materials to obtain first: Original devices, intensity measurement, exposure/sessions, supervision/contact, adherence and control records are needed. Calculate no new total time/exposure or exercise, breathing or treatment steps.
- Further research: Material needed: Original devices, intensity measurement, exposure/sessions, supervision/contact, adherence and control records are needed. Calculate no new total time/exposure or exercise, breathing or treatment steps. This records needed materials; no new research was executed.
- Conditions for verification: Material for Original intensity, exposure, delivery and actual adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Original intensity, exposure, delivery and actual adherence with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N17 · Were different comparators distinguished?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original text distinguishes trials of supervised/home training with 5% MVC sham, no-exercise and aerobic controls. Do not fill in the same comparator/blinding conditions for all reports.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Report-specific control intensity, exposure, contact, baseline adjustment, planned comparisons and denominators are unverified. Do not interchange comparator-specific effects.
- Required materials and conditions: Sham, no-exercise and aerobic controls and effects of interest
- Materials to obtain first: Report-specific control intensity, exposure, contact, baseline adjustment, planned comparisons and denominators are unverified. Do not interchange comparator-specific effects.
- Further research: Material needed: Report-specific control intensity, exposure, contact, baseline adjustment, planned comparisons and denominators are unverified. Do not interchange comparator-specific effects. This records needed materials; no new research was executed.
- Conditions for verification: Material for Sham, no-exercise and aerobic controls and effects of interest must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Sham, no-exercise and aerobic controls and effects of interest with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N18 · Were concurrent medication, activity and supervisory contact verified?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original text records treated participants and supervised/home conditions. Medication types, doses, changes, baseline activity, premeasurement conditions, contact and actual exposure details are absent.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Arm medication/changes, concurrent activity, adherence, measurement conditions, models, denominators and original effects are needed. Do not establish identical conditions or effects without medication.
- Required materials and conditions: Concurrent treatment, changes, actual exposure, measurement conditions and attribution
- Materials to obtain first: Arm medication/changes, concurrent activity, adherence, measurement conditions, models, denominators and original effects are needed. Do not establish identical conditions or effects without medication.
- Further research: Material needed: Arm medication/changes, concurrent activity, adherence, measurement conditions, models, denominators and original effects are needed. Do not establish identical conditions or effects without medication. This records needed materials; no new research was executed.
- Conditions for verification: Material for Concurrent treatment, changes, actual exposure, measurement conditions and attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Concurrent treatment, changes, actual exposure, measurement conditions and attribution with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N19 · Were randomization, blinding, measurement and timing verified?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Original evidence labels randomized trials, but allocation, concealment, evaluators, standardized measurement, prospective planning, multiple time points and detailed attrition are absent from summaries. Preserve original B2 and small-sample/attrition limitations.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Original methods, measurement procedures, blinding, baseline adjustment/missingness, planned endpoints/comparisons/timing and analysis plans are needed. Create no official method-assessment pass or new grade.
- Required materials and conditions: Allocation, concealment, evaluators, standardized measurement, planning and missingness
- Materials to obtain first: Original methods, measurement procedures, blinding, baseline adjustment/missingness, planned endpoints/comparisons/timing and analysis plans are needed. Create no official method-assessment pass or new grade.
- Further research: Material needed: Original methods, measurement procedures, blinding, baseline adjustment/missingness, planned endpoints/comparisons/timing and analysis plans are needed. Create no official method-assessment pass or new grade. This records needed materials; no new research was executed.
- Conditions for verification: Material for Allocation, concealment, evaluators, standardized measurement, planning and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Allocation, concealment, evaluators, standardized measurement, planning and missingness with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N20 · Are registration identifiers equivalent to reading original plans?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Farah NCT02348138 and Palmeira NCT03216317 are original identifiers; registration for the 2024 report is unverified. PMCID is preserved in the bibliography; external registration, plans, full texts and prospective-status comparisons were unread this run.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Original registration, changes, paper linkage, protocols/SAPs, planned endpoints, arm comparisons and denominators are needed. Identifiers, URLs and PMCID alone do not establish reading or prospective verification.
- Required materials and conditions: Registration, paper linkage, changes, protocols, SAPs and planned endpoints
- Materials to obtain first: Original registration, changes, paper linkage, protocols/SAPs, planned endpoints, arm comparisons and denominators are needed. Identifiers, URLs and PMCID alone do not establish reading or prospective verification.
- Further research: Material needed: Original registration, changes, paper linkage, protocols/SAPs, planned endpoints, arm comparisons and denominators are needed. Identifiers, URLs and PMCID alone do not establish reading or prospective verification. This records needed materials; no new research was executed.
- Conditions for verification: Material for Registration, paper linkage, changes, protocols, SAPs and planned endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Registration, paper linkage, changes, protocols, SAPs and planned endpoints with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N21 · What were funding, products, employee authors and design/analysis roles?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Preserve Farah public/academic support, Palmeira public primary-care support and the 2024 report's academic support. Public/academic wording or parent I2 does not become new certification of overall independence.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Disclosures of financial/device/product support, company/author affiliations, design/analysis/publication roles and institutional, recruitment and report relationships are unread. Do not fill in no support or involvement.
- Required materials and conditions: Financial/device/product support, author affiliations and design/analysis/publication control
- Materials to obtain first: Disclosures of financial/device/product support, company/author affiliations, design/analysis/publication roles and institutional, recruitment and report relationships are unread. Do not fill in no support or involvement.
- Further research: Material needed: Disclosures of financial/device/product support, company/author affiliations, design/analysis/publication roles and institutional, recruitment and report relationships are unread. Do not fill in no support or involvement. This records needed materials; no new research was executed.
- Conditions for verification: Material for Financial/device/product support, author affiliations and design/analysis/publication control must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Financial/device/product support, author affiliations and design/analysis/publication control with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N22 · Were pain, exercise pressure and vulnerable-group harms verified?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Original safety text records hand/arm pain, pressure rises during breath-holding/Valsalva and uncontrolled-hypertension/cardiovascular-disease boundaries. Trial-specific harm events, exposure, denominators and collection are absent from summaries.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Harm collection, severity/timing, events/affected people, denominators, actual exposure, stopping, medication/vulnerable groups and long-term data are needed. Null ambulatory pressure does not become no harm or safety certification.
- Required materials and conditions: Events, affected people, arm denominators, exposure, collection, stopping and follow-up
- Materials to obtain first: Harm collection, severity/timing, events/affected people, denominators, actual exposure, stopping, medication/vulnerable groups and long-term data are needed. Null ambulatory pressure does not become no harm or safety certification.
- Further research: Material needed: Harm collection, severity/timing, events/affected people, denominators, actual exposure, stopping, medication/vulnerable groups and long-term data are needed. Null ambulatory pressure does not become no harm or safety certification. This records needed materials; no new research was executed.
- Conditions for verification: Material for Events, affected people, arm denominators, exposure, collection, stopping and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Events, affected people, arm denominators, exposure, collection, stopping and follow-up with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N23 · Are subclaim grades the same as parent scores and axes?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Supervised office subclaim C and ambulatory subclaim D have no individual score, status or axes. Preserve parent C with 50 points, caution, B/S/R1/I2/EX/B2 and unrecorded precision as parent context.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Do not fill subclaims with parent scores/axes or turn unrecorded precision into default values, new scores or independence certification. Distinguish parent/subclaim application boundaries.
- Required materials and conditions: Absent subclaim score/status/axes versus the parent verdict
- Materials to obtain first: Do not fill subclaims with parent scores/axes or turn unrecorded precision into default values, new scores or independence certification. Distinguish parent/subclaim application boundaries.
- Further research: Material needed: Do not fill subclaims with parent scores/axes or turn unrecorded precision into default values, new scores or independence certification. Distinguish parent/subclaim application boundaries. This records needed materials; no new research was executed.
- Conditions for verification: Material for Absent subclaim score/status/axes versus the parent verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Absent subclaim score/status/axes versus the parent verdict with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N24 · How are representative information and both languages preserved?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Preserve complete bilingual texts and representative information. Representative 72 participants, 12 weeks, no exercise and office/central/ambulatory labels do not automatically apply to 63 or 84 participants, all day/night/home outcomes or each arm.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Report-specific delivery, supervision, measurement settings, endpoints, timing, denominators and original English comparison materials are needed. No external English comparison or correction review was performed this run.
- Required materials and conditions: Report-specific populations, supervision, measurement settings, outcomes, timing and denominators
- Materials to obtain first: Report-specific delivery, supervision, measurement settings, endpoints, timing, denominators and original English comparison materials are needed. No external English comparison or correction review was performed this run.
- Further research: Material needed: Report-specific delivery, supervision, measurement settings, endpoints, timing, denominators and original English comparison materials are needed. No external English comparison or correction review was performed this run. This records needed materials; no new research was executed.
- Conditions for verification: Material for Report-specific populations, supervision, measurement settings, outcomes, timing and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Report-specific populations, supervision, measurement settings, outcomes, timing and denominators with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N25 · How are actual reading and report/material counts distinguished?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The complete parent JSON was read for production. Historical verification, separation and cross-checks remain historical records; external materials are unread. Report/material counts do not count acquired papers, independent trials, participants or quality scores.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Original-material acquisition, actual reading and trial/report/cohort relationships are unverified. URLs/identifiers alone do not establish completed reading or unique-trial/participant totals.
- Required materials and conditions: Stored summaries, external reading and trial/report/cohort relationships
- Materials to obtain first: Original-material acquisition, actual reading and trial/report/cohort relationships are unverified. URLs/identifiers alone do not establish completed reading or unique-trial/participant totals.
- Further research: Material needed: Original-material acquisition, actual reading and trial/report/cohort relationships are unverified. URLs/identifiers alone do not establish completed reading or unique-trial/participant totals. This records needed materials; no new research was executed.
- Conditions for verification: Material for Stored summaries, external reading and trial/report/cohort relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Stored summaries, external reading and trial/report/cohort relationships with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N26 · What are the evidence date and correction history?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Preserve original evidence date 2026-09-07 and empty correction/deliberation records. Figure/table inconsistencies do not justify inventing corrections or turning production dates into evidence-verification dates.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: When originals/corrections are acquired, preserve and link complete texts, events, versions and reasons. No original-verdict change or external lookup was performed this run.
- Required materials and conditions: Original date, empty correction/deliberation records, production timing and original URLs
- Materials to obtain first: When originals/corrections are acquired, preserve and link complete texts, events, versions and reasons. No original-verdict change or external lookup was performed this run.
- Further research: Material needed: When originals/corrections are acquired, preserve and link complete texts, events, versions and reasons. No original-verdict change or external lookup was performed this run. This records needed materials; no new research was executed.
- Conditions for verification: Material for Original date, empty correction/deliberation records, production timing and original URLs must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Original date, empty correction/deliberation records, production timing and original URLs with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

### N27 · How will new materials and changed questions be updated?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Preserve original materials, conditions and observations. New materials are linked to supervision/controls, measurement settings, denominators, endpoints/timing/day-night, related reports and subclaim scope; no new lookup or reassessment occurred this run.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Updates must retain complete texts, criteria versions, events and reasons. Do not invent clinical calculations, effects/CIs, independence certification, exercise methods, pressure-medication reduction/replacement or treatment instructions.
- Required materials and conditions: Evidence updates, criteria revisions and original-verdict changes
- Materials to obtain first: Updates must retain complete texts, criteria versions, events and reasons. Do not invent clinical calculations, effects/CIs, independence certification, exercise methods, pressure-medication reduction/replacement or treatment instructions.
- Further research: Material needed: Updates must retain complete texts, criteria versions, events and reasons. Do not invent clinical calculations, effects/CIs, independence certification, exercise methods, pressure-medication reduction/replacement or treatment instructions. This records needed materials; no new research was executed.
- Conditions for verification: Material for Evidence updates, criteria revisions and original-verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Evidence updates, criteria revisions and original-verdict changes with supervised office SBP, omnibus tests, specific comparisons, within-group changes, measurement settings, denominators, attrition, directness and harm boundaries.
- Application exceptions: Preserve selected C and the note supporting the direction in small trials while specific adjusted effects remain unverified. Distinguish absent subclaim score/status/axes from parent C with 50 points. Omnibus tests, within-group changes and other measurement settings do not become new specific effects, CIs or independent replication. Create no new grades, safety certification or exercise, breathing, medication or treatment instructions.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: R01, R02, R03

## Evidence and sources

### R01

Farah BQ, et al. Supervised, but Not Home-Based, Isometric Training Improves Brachial and Central Blood Pressure in Medicated Hypertensive Patients. Front Physiol. 2018;9:961. PMID: 30083107. PMCID: PMC6065303. DOI: 10.3389/fphys.2018.00961.

[PubMed](https://pubmed.ncbi.nlm.nih.gov/30083107/)

Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread  
Findings recorded in the summary: Office SBP P=.041 and DBP P=.049; ambulatory SBP P=.650 and DBP P=.340  
Record level: Medicated hypertension, 72 randomized, 12 weeks and supervised/home/no-exercise 3-arm conditions. Office SBP P=.041 and DBP P=.049 are omnibus group-by-time tests; specific adjusted effects/95% CIs are unverified. Preserve null 24-hour SBP P=.650/DBP P=.340, figure/table arm-label inconsistencies and missing exact arm denominators.  
Independent replication: Supervised office SBP and the separate ambulatory-pressure question share Farah, Palmeira and the 2024 home-training reports. Report/cohort relationships and unique-trial/participant totals are unverified. Multiple sheets, measures and report participants are not counted as new independent trials or participant totals.

| Material | Public availability | Access status | Actually read | Notes |
|---|---|---|---|---|
| Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies. |
| External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies. |
| External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies. |
| Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies. |
| Protocol and analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies. |

### R02

Palmeira AC, et al. Effects of isometric handgrip training on blood pressure among hypertensive patients seen within public primary healthcare: a randomized controlled trial. Sao Paulo Med J. 2021;139:648-656. PMID: 34787298. PMCID: PMC9634841. DOI: 10.1590/1516-3180.2020.0796.R1.22042021.

[PubMed](https://pubmed.ncbi.nlm.nih.gov/34787298/)

Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread  
Findings recorded in the summary: Office SBP interaction positive; DBP and ambulatory pressure null  
Record level: In a 63-participant, 12-week randomized primary-care hypertension trial, preserve positive office-SBP interaction and null DBP/ambulatory pressure. Exact completion/analysis counts amid large attrition, arm denominators, original effects/CIs, P and models are unverified; do not copy P from the key trial.  
Independent replication: Supervised office SBP and the separate ambulatory-pressure question share Farah, Palmeira and the 2024 home-training reports. Report/cohort relationships and unique-trial/participant totals are unverified. Multiple sheets, measures and report participants are not counted as new independent trials or participant totals.

| Material | Public availability | Access status | Actually read | Notes |
|---|---|---|---|---|
| Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans. |
| External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans. |
| External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans. |
| Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans. |
| Protocol and analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans. |

### R03

Home-based isometric handgrip training in older adults with hypertension. J Am Geriatr Soc. 2024. PMID: 39392028. DOI: 10.1111/jgs.19213.

[PubMed](https://pubmed.ncbi.nlm.nih.gov/39392028/)

Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread  
Findings recorded in the summary: 24-hour ambulatory and between-group office pressure were null  
Record level: Preserve null 24-hour and between-group office pressure in the 2024 report of 84 older home-training participants. This does not replicate supervised effects under the same conditions; exact duration, comparator, effects/CIs, P and arm denominators are unverified.  
Independent replication: Supervised office SBP and the separate ambulatory-pressure question share Farah, Palmeira and the 2024 home-training reports. Report/cohort relationships and unique-trial/participant totals are unverified. Multiple sheets, measures and report participants are not counted as new independent trials or participant totals.

| Material | Public availability | Access status | Actually read | Notes |
|---|---|---|---|---|
| Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading. |
| External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading. |
| External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading. |
| Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading. |
| Protocol and analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading. |

## Review criteria and methods

These are Chamgap's own application conditions, informed by the relevant sections of official methodological guidance. They do not constitute official assessment-tool certification or a new efficacy score.

- M03 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03) · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13 · Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.
- M04 [Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04) · §4.5, §4.6.1–4.6.3, MECIR C42 · Distinguish studies from reports and link them; do not omit a study solely because results are unreported. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.
- M08 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08) · §8.1–8.2.3, Table 8.2.a · Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.
- M15 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15) · §15.2.4, §15.3.1–15.3.3 · Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.
- M19 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19) · §19.1.2, §19.2.1–19.2.4 · Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

## What the statuses mean

- Partly verified: Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified
- Unverified: Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety
- Review incomplete: Awaiting user review
- Met: Use only within the relevant condition's scope after user review; no automatic display in this preparation
- Not reported: Distinguish only within materials actually read; do not turn unread external materials into unreported findings
- Inaccessible: Not applied during this preparation because actual access was not tested
- Not applicable: Use with a reason for non-applicability based on an explicit question boundary
- Conflicting data: Judge after actual material comparison; review was not performed during this preparation
- Insufficient evidence for the conditions: Do not use as a clinical grade encompassing currently unread materials

## Change history

2026-10-18 · Public page/materials 1.0. Public pages and materials were prepared from the existing 27 items. No new clinical search, verification-status change or scoring was performed.