CHAMGAP
MethodologyVerdictsExplanations (KO)Evidence CheckCitation KitMonitoring

Routine thrombus aspiration added × Thirty-day all-cause mortality in STEMI — TASTE evidence sheet

Select a review item to see its details.
Required evidence, verification status and materials actually read
ItemAVerification statusBReading scopeCReview itemDCurrent findingsEWhy unverifiedFRequired materials and conditionsGFurther research
1 Partly verified Full text not readStored summary read N01 · Comparative efficacyWere the selected claim and existing verdict record distinguished?Required
The selected claim is reduced thirty-day all-cause mortality in STEMI; the root grade D, score 34, Good safety label and axes E0/I1/B0/C0 are preserved. Distinguish the existing history from the current verdict record.
R01
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not turn the MAIN claim into a subclaim or introduce parent-inheritance or missing-subclaim-score explanations. Preserve the actual values, presence or absence and original verdict without a new verdict or split.
Preservation of the existing claim wording, verdict values, history and empty values
Link original materials and decisions to the actual MAIN question and root verdict record.
2 Partly verified Full text not readStored summary read N02 · Comparative efficacyWhat are the actual population, eligibility and baseline for primary PCI in STEMI?Required
TASTE asks about adding routine manual thrombus aspiration to primary PCI in ST-elevation myocardial infarction.
R01
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Detailed diagnosis, onset and treatment times, shock and thrombus risks, eligibility, exclusions and institution-specific characteristics are not detailed in the summary.
Original STEMI, entry time, PCI, eligibility, institutions and denominators
Obtain original population, diagnosis, eligibility, time points, institutions, baseline and denominator materials.
3 Partly verified Full text not readStored summary read N03 · Comparative efficacyDo routine aspiration added, PCI itself and selective aspiration involve the same comparison?Required
The original question is adding routine manual thrombus aspiration before primary PCI. Verdict 1791 is a different comparison concerning PCI itself.
R01 R02
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not transfer the finding to selective or rescue aspiration, other devices or PCI-versus-thrombolysis effects. Device, actual-use, antithrombotic and concurrent-treatment details were not read; no procedural-method or selection instructions are supplied.
Original additional procedure, comparator, common PCI, actual exposure and concurrent treatment
Obtain original aspiration, comparator, actual implementation, rescue, crossover and common-treatment materials.
4 Partly verified Full text not readStored summary read N04 · Comparative efficacyAre SWEDEHEART registry randomization and observational associations distinguished?Required
The source records a SWEDEHEART-based registry RCT that made recruitment, randomization and follow-up more efficient.
R01
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not turn registry use into an observational design or use routine-care efficiency as certification of every effect or of safety. Detailed data collection and institutional scope were not read.
Original recruitment, randomization, registry follow-up, analysis and institutions
Obtain original registry recruitment, allocation, follow-up, ascertainment and denominators.
5 Partly verified Full text not readStored summary read N05 · Comparative efficacyWere the 7,244 participants and each group's mortality denominators preserved in their original form?Required
The original source records 7,244 participants: aspiration 103/3621 (2.8%) versus control 110/3623 (3.0%).
R01
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not independently add people, repeated events, institutions or related verdicts. No new death or participant totals, proportions, NNT or follow-up rates are calculated.
Original allocation, groups, deaths, analysis and follow-up denominators
Obtain original allocation, analysis, group denominators, events and follow-up tables.
6 Partly verified Full text not readStored summary read N06 · Comparative efficacyWhat are the thirty-day all-cause mortality definition and national-registry ascertainment?Required
The original primary endpoint is thirty-day all-cause mortality; national death-registry follow-up is recorded as the original basis for a hard endpoint.
R01
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not replace this with cause-specific effects, cardiovascular mortality, long-term survival or a periprocedural period. Detailed reference points, events outside the country and ascertainment procedures were not read.
Death definition, reference point, thirty-day window, registry and external events
Obtain original death definitions, time points, ascertainment, registry linkage and denominators.
7 Partly verified Full text not readStored summary read N07 · Comparative efficacyAre HR 0.94, the 95% CI of 0.72–1.22 and the original −0.2 percentage points preserved?Required
The original thirty-day mortality HR is 0.94 (95% CI 0.72–1.22), with an absolute difference of −0.2 percentage points.
R01
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not turn this into an RR, an individual protection rate or a reverse-direction effect. Do not fill in absent original P values, an absolute-difference CI or adjusted models; no new calculations are performed.
Original time-to-event effect, comparison direction, interval, absolute difference and model
Obtain original effect direction, models, tests, CI and denominators.
8 Partly verified Full text not readStored summary read N08 · Comparative efficacyWere the null result and CI tails allowing benefit and harm distinguished?Required
The source describes remaining possibilities of substantial benefit and harm, without establishing absence of benefit; the CI lower bound of 0.72 leaves room for a reduction.
R01
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not interpret a null result as an exact zero effect, equivalence or absence of all risk. No new MCID, power calculation, margin or hypothetical numbers are supplied.
Original interval, clinical boundaries, precision and interpretation
Obtain original clinical boundaries, precision, denominators and assumptions.
9 Partly verified Full text not readStored summary read N09 · Comparative efficacyWere the roles of online allocation, unmasked procedures, objective mortality and ITT distinguished?Required
The original text records online registry randomization before PCI, unmasked procedures, the national death registry, ITT and complete thirty-day vital-status follow-up as the historical basis for B0.
R01
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. This is not a new original-paper review, a finding of no bias or certification of complete follow-up for every outcome. Operator, analyst, institutional and intervention-crossover details were not read.
Allocation, concealment, blinding, event ascertainment, analysis and missingness
Obtain original allocation, ascertainment, actual procedures, analysis and missing-data materials.
10 Partly verified Full text not readStored summary read N10 · Comparative efficacyWhat are the access gaps for registration, prespecified thirty-day mortality, hierarchy and subgroups?Required
The historical consistency of the original registration identifier NCT01093404 with the prespecified primary endpoint of thirty-day all-cause mortality is preserved.
R01
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Registration and plans were not newly read; multiplicity, test P values, prespecified risk subgroups and analysis changes were not newly established.
Registration, protocol, SAP, hierarchy, changes and models
Obtain original registration, plans, hierarchy, subgroups, changes and models.
11 Unverified Full text not readStored summary read N11 · Comparative efficacyWas the finding extended to longer periods, specific patients, rescue aspiration or procedural mechanisms?Required
The original core outcome is thirty-day all-cause mortality with routine aspiration added; the original explanation says that performing thrombus removal does not imply a survival benefit.
R01
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not create effects or suitability findings for other periods, specific thrombus groups, rescue procedures or all aspiration. No implementation or treatment instructions are supplied.
Periods, populations, selective exposure and direct clinical outcomes
Obtain original direct subgroup and period-specific outcomes, interactions and actual exposure.
12 Partly verified Full text not readStored summary read N12 · Comparative efficacyWhat are the 1791 cross-citation, trial question and relationships within the same report?Required
The original 1791 link is a cross-citation distinguishing the effect of primary PCI itself from adding aspiration. The original outcomes of one TASTE report are preserved.
R01 R02
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Verdict 1791's target and original papers were not newly read or used as direct replication of the same question or added participants. Independent counts and total participants remain null.
Original bibliography, related verdict, additional-procedure question and cohort relationships
Link new reports by original identifier, cohort and question.
13 Partly verified Full text not readStored summary read N13 · Comparative efficacyWere public and regional support distinguished from unrestricted grants from three companies?Required
Swedish Research Council and local or regional association support, and unrestricted research grants from Terumo, Medtronic and Vascular Solutions, are preserved with the original I1.
R01
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Public support alone does not certify absence of company involvement, complete independence or absence of device provision. Employee authors, in-kind support and design, analysis and writing roles were separately not read.
Cash, devices, in-kind support, affiliations, external analysis and research roles
Obtain original funding, devices, in-kind support, affiliation, design, analysis and writing disclosures.
14 Partly verified Full text not readStored summary read N14 · Supplementary harm evidenceWhat is the window for stroke or neurological complications of 0.5% and P=.87 at discharge?Required
The original values for stroke or neurological complications at discharge are 0.5% versus 0.5%, P=.87.
R01
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not transfer the discharge window to thirty-day or long-term events or create original participant counts, CI, relatedness or equivalence. Composite type, denominators and original ascertainment procedures were not read.
Harm definitions, observation window, people and events, original denominators and tests
Obtain original harm definitions, people, events, periods, denominators, CI and tests.
15 Unverified Full text not readStored summary read N15 · Supplementary harm evidenceWhat are the original Good safety label, no-increase finding and gaps in rare or long-term harms?Required
The original Good safety label and description of neurological events at discharge are preserved as history.
R01
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not extend equal proportions or P values, or no increase, to absence of all harm, long-term safety or effects of every device. Other harms, discontinuation, crossover and safety-population details were not read.
Other harms, relatedness, actual exposure, collection and long-term follow-up
Obtain original overall-harm, exposure, relatedness, discontinuation, denominator and rare or long-term materials.
16 Partly verified Full text not readStored summary read N16 · Comparative efficacyWere the summary, paper and related-verdict URLs, registration identifier and actual access distinguished?Required
The entire stored summary of the designated existing verdict was read for preparation, and the original source links and registration identifier were linked.
R01 R02
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. External abstracts, full texts, registrations, protocols, SAP and related-verdict targets were not read, and no separate link testing was performed. Do not create new URLs, DOI or original-study information.
Original bibliography, URLs, registration, material-specific access and cross-citations
Link user-provided original materials by material type and actual access.
17 Partly verified Full text not readStored summary read N17 · Comparative efficacyWere MAIN languages, dates, corrections, empty arrays, false/null, empty values and candidate history preserved?Supplementary
Preserve 2026-08-26, empty corrections/subclaims arrays, the empty deliberation string, root grade/score/safety/axes, Korean and English, false/null and empty values unchanged.
R01
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. This root record is not a case of missing subclaim scores or parent inheritance. Original verification and path checks, B0, support and safety assessments are historical, not a completed current review. Original candidate pending/eligible states are also historical.
Original root verdict, Korean and English, cut-off, corrections, history and presence or absence
Link user materials and decisions to full original preservation and separate events.
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17 itemsWhat the statuses mean

Assessment scope

Stored-material review date
Not recorded
Original evidence cut-off
2026-08-26
Scope actually checked
Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean
This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population
STEMI participants undergoing primary PCI; original detailed eligibility and baseline information not read
Ingredient, formulation and route
Historical conditions of adding routine manual thrombus aspiration before primary PCI
Dose
Original details of the actual procedure, technique, devices, conduits and exposure not read; no guidance on individual implementation, selection or treatment
Comparator
Comparator without routine aspiration added to primary PCI; detailed actual and rescue exposure not read
Measured outcome
Original thirty-day all-cause mortality; neurological harm at discharge considered separately
Duration
Distinguish thirty-day mortality from neurological complications at discharge
Questions outside this scope
Converting the MAIN claim into a subclaim or a new split; Interpreting a null result or CI as an exact zero effect, equivalence or absence of all harm; Independently adding participants or reports shared across other comparative verdicts or time points; Calculating new survival rates, event counts or differences from mortality rates; Recommendations on individual procedures, surgery, devices, treatment selection or implementation

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

R01 · Fröbert O, et al. N Engl J Med. 2013. PMID: 23991656.

PubMed

Material type
Original RCT paper report
Materials actually read
Summary read; external materials and linked targets not read
Findings recorded in the stored summary
2.8% versus 3.0%; HR 0.94 (95% CI 0.72–1.22); absolute difference −0.2 percentage points
Record level
Existing review summary; external papers were not compared during this preparation
Study overlap and independent replication
Family IDs link relationships and do not certify independent counts; reports, periods, events, institutions, cross-citations and participants are not independently added. F01: the same RCT, efficacy, harm and cohort shared by the designated MAIN claim. F02: an existing-verdict cross-citation concerning another population or comparator; target not read and independent replication not certified.
Public availability, access and reading status by material
MaterialPublic availabilityAccess statusActually readNotes
Stored existing review summaryOriginal URL preservedSummary readSummary readReport-specific summary links within the same stored summary
External abstractOriginal URL preservedNot readNot readExternal materials and related-verdict targets not read; a URL does not certify reading or review
External full paperNo separate original URLNot readNot readExternal materials and related-verdict targets not read; a URL does not certify reading or review
External registrationNo separate original URLNot readNot readExternal materials and related-verdict targets not read; a URL does not certify reading or review
External protocol and SAPNo separate original URLNot readNot readExternal materials and related-verdict targets not read; a URL does not certify reading or review

R02 · Chamgap 1791 Primary PCI × STEMI

Official source

Material type
Cross-citation of an existing verdict; original trial bibliography and contents not obtained
Materials actually read
Summary read; external materials and linked targets not read
Findings recorded in the stored summary
Distinguish the effect of PCI itself from the null result for aspiration added.
Record level
Original cross-citation concerning another population or comparator; not direct MAIN evidence or independent replication
Study overlap and independent replication
Family IDs link relationships and do not certify independent counts; reports, periods, events, institutions, cross-citations and participants are not independently added. F01: the same RCT, efficacy, harm and cohort shared by the designated MAIN claim. F02: an existing-verdict cross-citation concerning another population or comparator; target not read and independent replication not certified.
Public availability, access and reading status by material
MaterialPublic availabilityAccess statusActually readNotes
Stored existing review summaryOriginal URL preservedSummary readSummary readReport-specific summary links within the same stored summary
Original related-verdict linkOriginal URL preservedNot readNot readExternal materials and related-verdict targets not read; a URL does not certify reading or review
External full paperNo separate original URLNot readNot readExternal materials and related-verdict targets not read; a URL does not certify reading or review
External registrationNo separate original URLNot readNot readExternal materials and related-verdict targets not read; a URL does not certify reading or review
External protocol and SAPNo separate original URLNot readNot readExternal materials and related-verdict targets not read; a URL does not certify reading or review

Report counts versus independent study counts

Family IDs link relationships and do not certify independent counts; reports, periods, events, institutions, cross-citations and participants are not independently added. F01: the same RCT, efficacy, harm and cohort shared by the designated MAIN claim. F02: an existing-verdict cross-citation concerning another population or comparator; target not read and independent replication not certified.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Were the selected claim and existing verdict record distinguished?
Required materials and conditions
Preservation of the existing claim wording, verdict values, history and empty values
Conditions for verification
Preservation of the existing claim wording, verdict values, history and empty values
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N02 · What are the actual population, eligibility and baseline for primary PCI in STEMI?
Required materials and conditions
Original STEMI, entry time, PCI, eligibility, institutions and denominators
Conditions for verification
Original STEMI, entry time, PCI, eligibility, institutions and denominators
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N03 · Do routine aspiration added, PCI itself and selective aspiration involve the same comparison?
Required materials and conditions
Original additional procedure, comparator, common PCI, actual exposure and concurrent treatment
Conditions for verification
Original additional procedure, comparator, common PCI, actual exposure and concurrent treatment
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N04 · Are SWEDEHEART registry randomization and observational associations distinguished?
Required materials and conditions
Original recruitment, randomization, registry follow-up, analysis and institutions
Conditions for verification
Original recruitment, randomization, registry follow-up, analysis and institutions
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N05 · Were the 7,244 participants and each group's mortality denominators preserved in their original form?
Required materials and conditions
Original allocation, groups, deaths, analysis and follow-up denominators
Conditions for verification
Original allocation, groups, deaths, analysis and follow-up denominators
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N06 · What are the thirty-day all-cause mortality definition and national-registry ascertainment?
Required materials and conditions
Death definition, reference point, thirty-day window, registry and external events
Conditions for verification
Death definition, reference point, thirty-day window, registry and external events
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N07 · Are HR 0.94, the 95% CI of 0.72–1.22 and the original −0.2 percentage points preserved?
Required materials and conditions
Original time-to-event effect, comparison direction, interval, absolute difference and model
Conditions for verification
Original time-to-event effect, comparison direction, interval, absolute difference and model
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N08 · Were the null result and CI tails allowing benefit and harm distinguished?
Required materials and conditions
Original interval, clinical boundaries, precision and interpretation
Conditions for verification
Original interval, clinical boundaries, precision and interpretation
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N09 · Were the roles of online allocation, unmasked procedures, objective mortality and ITT distinguished?
Required materials and conditions
Allocation, concealment, blinding, event ascertainment, analysis and missingness
Conditions for verification
Allocation, concealment, blinding, event ascertainment, analysis and missingness
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N10 · What are the access gaps for registration, prespecified thirty-day mortality, hierarchy and subgroups?
Required materials and conditions
Registration, protocol, SAP, hierarchy, changes and models
Conditions for verification
Registration, protocol, SAP, hierarchy, changes and models
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N11 · Was the finding extended to longer periods, specific patients, rescue aspiration or procedural mechanisms?
Required materials and conditions
Periods, populations, selective exposure and direct clinical outcomes
Conditions for verification
Periods, populations, selective exposure and direct clinical outcomes
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N12 · What are the 1791 cross-citation, trial question and relationships within the same report?
Required materials and conditions
Original bibliography, related verdict, additional-procedure question and cohort relationships
Conditions for verification
Original bibliography, related verdict, additional-procedure question and cohort relationships
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N13 · Were public and regional support distinguished from unrestricted grants from three companies?
Required materials and conditions
Cash, devices, in-kind support, affiliations, external analysis and research roles
Conditions for verification
Cash, devices, in-kind support, affiliations, external analysis and research roles
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N14 · What is the window for stroke or neurological complications of 0.5% and P=.87 at discharge?
Required materials and conditions
Harm definitions, observation window, people and events, original denominators and tests
Conditions for verification
Harm definitions, observation window, people and events, original denominators and tests
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N15 · What are the original Good safety label, no-increase finding and gaps in rare or long-term harms?
Required materials and conditions
Other harms, relatedness, actual exposure, collection and long-term follow-up
Conditions for verification
Other harms, relatedness, actual exposure, collection and long-term follow-up
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N16 · Were the summary, paper and related-verdict URLs, registration identifier and actual access distinguished?
Required materials and conditions
Original bibliography, URLs, registration, material-specific access and cross-citations
Conditions for verification
Original bibliography, URLs, registration, material-specific access and cross-citations
Requirement and applicability
Required
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
N17 · Were MAIN languages, dates, corrections, empty arrays, false/null, empty values and candidate history preserved?
Required materials and conditions
Original root verdict, Korean and English, cut-off, corrections, history and presence or absence
Conditions for verification
Original root verdict, Korean and English, cut-off, corrections, history and presence or absence
Requirement and applicability
Supplementary
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction
Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle
Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review
Existing stored methodological links reused for preparation; no current review, reassessment of methodological content or external-link testing

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle
Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review
Existing stored methodological links reused for preparation; no current review, reassessment of methodological content or external-link testing

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle
Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review
Existing stored methodological links reused for preparation; no current review, reassessment of methodological content or external-link testing

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle
Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review
Existing stored methodological links reused for preparation; no current review, reassessment of methodological content or external-link testing

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle
Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review
Existing stored methodological links reused for preparation; no current review, reassessment of methodological content or external-link testing
What the statuses mean
Partly verified
Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified
Unverified
Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety
Review incomplete
Awaiting user review
Met
Use only within the relevant condition's scope after user review; no automatic display in this preparation
Not reported
Distinguish only within materials actually read; do not turn unread external materials into unreported findings
Inaccessible
Not applied during this preparation because actual access was not tested
Not applicable
Use with a reason for non-applicability based on an explicit question boundary
Conflicting data
Judge after actual material comparison; review was not performed during this preparation
Insufficient evidence for the conditions
Do not use as a clinical grade encompassing currently unread materials

Change history

2026-10-10 · Public page/material version 1.0

Public pages and materials were prepared from the existing 17 items. No new clinical search, verification-status changes or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-08-26) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

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N01 · Were the selected claim and existing verdict record distinguished?

Current findings
The selected claim is reduced thirty-day all-cause mortality in STEMI; the root grade D, score 34, Good safety label and axes E0/I1/B0/C0 are preserved. Distinguish the existing history from the current verdict record.
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not turn the MAIN claim into a subclaim or introduce parent-inheritance or missing-subclaim-score explanations. Preserve the actual values, presence or absence and original verdict without a new verdict or split.
Reason for missing information
Do not turn the MAIN claim into a subclaim or introduce parent-inheritance or missing-subclaim-score explanations. Preserve the actual values, presence or absence and original verdict without a new verdict or split.
Required materials and conditions
Preservation of the existing claim wording, verdict values, history and empty values
Materials to obtain first
Do not turn the MAIN claim into a subclaim or introduce parent-inheritance or missing-subclaim-score explanations. Preserve the actual values, presence or absence and original verdict without a new verdict or split.
Further research
Link original materials and decisions to the actual MAIN question and root verdict record.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Preservation of the existing claim wording, verdict values, history and empty values
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01

N02 · What are the actual population, eligibility and baseline for primary PCI in STEMI?

Current findings
TASTE asks about adding routine manual thrombus aspiration to primary PCI in ST-elevation myocardial infarction.
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Detailed diagnosis, onset and treatment times, shock and thrombus risks, eligibility, exclusions and institution-specific characteristics are not detailed in the summary.
Reason for missing information
Detailed diagnosis, onset and treatment times, shock and thrombus risks, eligibility, exclusions and institution-specific characteristics are not detailed in the summary.
Required materials and conditions
Original STEMI, entry time, PCI, eligibility, institutions and denominators
Materials to obtain first
Detailed diagnosis, onset and treatment times, shock and thrombus risks, eligibility, exclusions and institution-specific characteristics are not detailed in the summary.
Further research
Obtain original population, diagnosis, eligibility, time points, institutions, baseline and denominator materials.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Original STEMI, entry time, PCI, eligibility, institutions and denominators
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01

N03 · Do routine aspiration added, PCI itself and selective aspiration involve the same comparison?

Current findings
The original question is adding routine manual thrombus aspiration before primary PCI. Verdict 1791 is a different comparison concerning PCI itself.
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not transfer the finding to selective or rescue aspiration, other devices or PCI-versus-thrombolysis effects. Device, actual-use, antithrombotic and concurrent-treatment details were not read; no procedural-method or selection instructions are supplied.
Reason for missing information
Do not transfer the finding to selective or rescue aspiration, other devices or PCI-versus-thrombolysis effects. Device, actual-use, antithrombotic and concurrent-treatment details were not read; no procedural-method or selection instructions are supplied.
Required materials and conditions
Original additional procedure, comparator, common PCI, actual exposure and concurrent treatment
Materials to obtain first
Do not transfer the finding to selective or rescue aspiration, other devices or PCI-versus-thrombolysis effects. Device, actual-use, antithrombotic and concurrent-treatment details were not read; no procedural-method or selection instructions are supplied.
Further research
Obtain original aspiration, comparator, actual implementation, rescue, crossover and common-treatment materials.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Original additional procedure, comparator, common PCI, actual exposure and concurrent treatment
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01 R02

N04 · Are SWEDEHEART registry randomization and observational associations distinguished?

Current findings
The source records a SWEDEHEART-based registry RCT that made recruitment, randomization and follow-up more efficient.
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not turn registry use into an observational design or use routine-care efficiency as certification of every effect or of safety. Detailed data collection and institutional scope were not read.
Reason for missing information
Do not turn registry use into an observational design or use routine-care efficiency as certification of every effect or of safety. Detailed data collection and institutional scope were not read.
Required materials and conditions
Original recruitment, randomization, registry follow-up, analysis and institutions
Materials to obtain first
Do not turn registry use into an observational design or use routine-care efficiency as certification of every effect or of safety. Detailed data collection and institutional scope were not read.
Further research
Obtain original registry recruitment, allocation, follow-up, ascertainment and denominators.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Original recruitment, randomization, registry follow-up, analysis and institutions
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01

N05 · Were the 7,244 participants and each group's mortality denominators preserved in their original form?

Current findings
The original source records 7,244 participants: aspiration 103/3621 (2.8%) versus control 110/3623 (3.0%).
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not independently add people, repeated events, institutions or related verdicts. No new death or participant totals, proportions, NNT or follow-up rates are calculated.
Reason for missing information
Do not independently add people, repeated events, institutions or related verdicts. No new death or participant totals, proportions, NNT or follow-up rates are calculated.
Required materials and conditions
Original allocation, groups, deaths, analysis and follow-up denominators
Materials to obtain first
Do not independently add people, repeated events, institutions or related verdicts. No new death or participant totals, proportions, NNT or follow-up rates are calculated.
Further research
Obtain original allocation, analysis, group denominators, events and follow-up tables.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Original allocation, groups, deaths, analysis and follow-up denominators
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01

N06 · What are the thirty-day all-cause mortality definition and national-registry ascertainment?

Current findings
The original primary endpoint is thirty-day all-cause mortality; national death-registry follow-up is recorded as the original basis for a hard endpoint.
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not replace this with cause-specific effects, cardiovascular mortality, long-term survival or a periprocedural period. Detailed reference points, events outside the country and ascertainment procedures were not read.
Reason for missing information
Do not replace this with cause-specific effects, cardiovascular mortality, long-term survival or a periprocedural period. Detailed reference points, events outside the country and ascertainment procedures were not read.
Required materials and conditions
Death definition, reference point, thirty-day window, registry and external events
Materials to obtain first
Do not replace this with cause-specific effects, cardiovascular mortality, long-term survival or a periprocedural period. Detailed reference points, events outside the country and ascertainment procedures were not read.
Further research
Obtain original death definitions, time points, ascertainment, registry linkage and denominators.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Death definition, reference point, thirty-day window, registry and external events
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01

N07 · Are HR 0.94, the 95% CI of 0.72–1.22 and the original −0.2 percentage points preserved?

Current findings
The original thirty-day mortality HR is 0.94 (95% CI 0.72–1.22), with an absolute difference of −0.2 percentage points.
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not turn this into an RR, an individual protection rate or a reverse-direction effect. Do not fill in absent original P values, an absolute-difference CI or adjusted models; no new calculations are performed.
Reason for missing information
Do not turn this into an RR, an individual protection rate or a reverse-direction effect. Do not fill in absent original P values, an absolute-difference CI or adjusted models; no new calculations are performed.
Required materials and conditions
Original time-to-event effect, comparison direction, interval, absolute difference and model
Materials to obtain first
Do not turn this into an RR, an individual protection rate or a reverse-direction effect. Do not fill in absent original P values, an absolute-difference CI or adjusted models; no new calculations are performed.
Further research
Obtain original effect direction, models, tests, CI and denominators.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Original time-to-event effect, comparison direction, interval, absolute difference and model
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01

N08 · Were the null result and CI tails allowing benefit and harm distinguished?

Current findings
The source describes remaining possibilities of substantial benefit and harm, without establishing absence of benefit; the CI lower bound of 0.72 leaves room for a reduction.
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not interpret a null result as an exact zero effect, equivalence or absence of all risk. No new MCID, power calculation, margin or hypothetical numbers are supplied.
Reason for missing information
Do not interpret a null result as an exact zero effect, equivalence or absence of all risk. No new MCID, power calculation, margin or hypothetical numbers are supplied.
Required materials and conditions
Original interval, clinical boundaries, precision and interpretation
Materials to obtain first
Do not interpret a null result as an exact zero effect, equivalence or absence of all risk. No new MCID, power calculation, margin or hypothetical numbers are supplied.
Further research
Obtain original clinical boundaries, precision, denominators and assumptions.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Original interval, clinical boundaries, precision and interpretation
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01

N09 · Were the roles of online allocation, unmasked procedures, objective mortality and ITT distinguished?

Current findings
The original text records online registry randomization before PCI, unmasked procedures, the national death registry, ITT and complete thirty-day vital-status follow-up as the historical basis for B0.
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. This is not a new original-paper review, a finding of no bias or certification of complete follow-up for every outcome. Operator, analyst, institutional and intervention-crossover details were not read.
Reason for missing information
This is not a new original-paper review, a finding of no bias or certification of complete follow-up for every outcome. Operator, analyst, institutional and intervention-crossover details were not read.
Required materials and conditions
Allocation, concealment, blinding, event ascertainment, analysis and missingness
Materials to obtain first
This is not a new original-paper review, a finding of no bias or certification of complete follow-up for every outcome. Operator, analyst, institutional and intervention-crossover details were not read.
Further research
Obtain original allocation, ascertainment, actual procedures, analysis and missing-data materials.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Allocation, concealment, blinding, event ascertainment, analysis and missingness
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01

N10 · What are the access gaps for registration, prespecified thirty-day mortality, hierarchy and subgroups?

Current findings
The historical consistency of the original registration identifier NCT01093404 with the prespecified primary endpoint of thirty-day all-cause mortality is preserved.
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Registration and plans were not newly read; multiplicity, test P values, prespecified risk subgroups and analysis changes were not newly established.
Reason for missing information
Registration and plans were not newly read; multiplicity, test P values, prespecified risk subgroups and analysis changes were not newly established.
Required materials and conditions
Registration, protocol, SAP, hierarchy, changes and models
Materials to obtain first
Registration and plans were not newly read; multiplicity, test P values, prespecified risk subgroups and analysis changes were not newly established.
Further research
Obtain original registration, plans, hierarchy, subgroups, changes and models.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Registration, protocol, SAP, hierarchy, changes and models
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01

N11 · Was the finding extended to longer periods, specific patients, rescue aspiration or procedural mechanisms?

Current findings
The original core outcome is thirty-day all-cause mortality with routine aspiration added; the original explanation says that performing thrombus removal does not imply a survival benefit.
Verification status
Unverified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not create effects or suitability findings for other periods, specific thrombus groups, rescue procedures or all aspiration. No implementation or treatment instructions are supplied.
Reason for missing information
Do not create effects or suitability findings for other periods, specific thrombus groups, rescue procedures or all aspiration. No implementation or treatment instructions are supplied.
Required materials and conditions
Periods, populations, selective exposure and direct clinical outcomes
Materials to obtain first
Do not create effects or suitability findings for other periods, specific thrombus groups, rescue procedures or all aspiration. No implementation or treatment instructions are supplied.
Further research
Obtain original direct subgroup and period-specific outcomes, interactions and actual exposure.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Periods, populations, selective exposure and direct clinical outcomes
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01

N12 · What are the 1791 cross-citation, trial question and relationships within the same report?

Current findings
The original 1791 link is a cross-citation distinguishing the effect of primary PCI itself from adding aspiration. The original outcomes of one TASTE report are preserved.
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Verdict 1791's target and original papers were not newly read or used as direct replication of the same question or added participants. Independent counts and total participants remain null.
Reason for missing information
Verdict 1791's target and original papers were not newly read or used as direct replication of the same question or added participants. Independent counts and total participants remain null.
Required materials and conditions
Original bibliography, related verdict, additional-procedure question and cohort relationships
Materials to obtain first
Verdict 1791's target and original papers were not newly read or used as direct replication of the same question or added participants. Independent counts and total participants remain null.
Further research
Link new reports by original identifier, cohort and question.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Original bibliography, related verdict, additional-procedure question and cohort relationships
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01 R02

N13 · Were public and regional support distinguished from unrestricted grants from three companies?

Current findings
Swedish Research Council and local or regional association support, and unrestricted research grants from Terumo, Medtronic and Vascular Solutions, are preserved with the original I1.
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Public support alone does not certify absence of company involvement, complete independence or absence of device provision. Employee authors, in-kind support and design, analysis and writing roles were separately not read.
Reason for missing information
Public support alone does not certify absence of company involvement, complete independence or absence of device provision. Employee authors, in-kind support and design, analysis and writing roles were separately not read.
Required materials and conditions
Cash, devices, in-kind support, affiliations, external analysis and research roles
Materials to obtain first
Public support alone does not certify absence of company involvement, complete independence or absence of device provision. Employee authors, in-kind support and design, analysis and writing roles were separately not read.
Further research
Obtain original funding, devices, in-kind support, affiliation, design, analysis and writing disclosures.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Cash, devices, in-kind support, affiliations, external analysis and research roles
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01

N14 · What is the window for stroke or neurological complications of 0.5% and P=.87 at discharge?

Current findings
The original values for stroke or neurological complications at discharge are 0.5% versus 0.5%, P=.87.
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not transfer the discharge window to thirty-day or long-term events or create original participant counts, CI, relatedness or equivalence. Composite type, denominators and original ascertainment procedures were not read.
Reason for missing information
Do not transfer the discharge window to thirty-day or long-term events or create original participant counts, CI, relatedness or equivalence. Composite type, denominators and original ascertainment procedures were not read.
Required materials and conditions
Harm definitions, observation window, people and events, original denominators and tests
Materials to obtain first
Do not transfer the discharge window to thirty-day or long-term events or create original participant counts, CI, relatedness or equivalence. Composite type, denominators and original ascertainment procedures were not read.
Further research
Obtain original harm definitions, people, events, periods, denominators, CI and tests.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Harm definitions, observation window, people and events, original denominators and tests
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01

N15 · What are the original Good safety label, no-increase finding and gaps in rare or long-term harms?

Current findings
The original Good safety label and description of neurological events at discharge are preserved as history.
Verification status
Unverified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. Do not extend equal proportions or P values, or no increase, to absence of all harm, long-term safety or effects of every device. Other harms, discontinuation, crossover and safety-population details were not read.
Reason for missing information
Do not extend equal proportions or P values, or no increase, to absence of all harm, long-term safety or effects of every device. Other harms, discontinuation, crossover and safety-population details were not read.
Required materials and conditions
Other harms, relatedness, actual exposure, collection and long-term follow-up
Materials to obtain first
Do not extend equal proportions or P values, or no increase, to absence of all harm, long-term safety or effects of every device. Other harms, discontinuation, crossover and safety-population details were not read.
Further research
Obtain original overall-harm, exposure, relatedness, discontinuation, denominator and rare or long-term materials.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Other harms, relatedness, actual exposure, collection and long-term follow-up
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01

N16 · Were the summary, paper and related-verdict URLs, registration identifier and actual access distinguished?

Current findings
The entire stored summary of the designated existing verdict was read for preparation, and the original source links and registration identifier were linked.
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. External abstracts, full texts, registrations, protocols, SAP and related-verdict targets were not read, and no separate link testing was performed. Do not create new URLs, DOI or original-study information.
Reason for missing information
External abstracts, full texts, registrations, protocols, SAP and related-verdict targets were not read, and no separate link testing was performed. Do not create new URLs, DOI or original-study information.
Required materials and conditions
Original bibliography, URLs, registration, material-specific access and cross-citations
Materials to obtain first
External abstracts, full texts, registrations, protocols, SAP and related-verdict targets were not read, and no separate link testing was performed. Do not create new URLs, DOI or original-study information.
Further research
Link user-provided original materials by material type and actual access.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Original bibliography, URLs, registration, material-specific access and cross-citations
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01 R02

N17 · Were MAIN languages, dates, corrections, empty arrays, false/null, empty values and candidate history preserved?

Current findings
Preserve 2026-08-26, empty corrections/subclaims arrays, the empty deliberation string, root grade/score/safety/axes, Korean and English, false/null and empty values unchanged.
Verification status
Partly verified
Materials actually read
Summary read; external materials and linked targets not read
Why unverified
Only the relevant stored-summary information is recorded; detailed original materials and user review remain outstanding. This root record is not a case of missing subclaim scores or parent inheritance. Original verification and path checks, B0, support and safety assessments are historical, not a completed current review. Original candidate pending/eligible states are also historical.
Reason for missing information
This root record is not a case of missing subclaim scores or parent inheritance. Original verification and path checks, B0, support and safety assessments are historical, not a completed current review. Original candidate pending/eligible states are also historical.
Required materials and conditions
Original root verdict, Korean and English, cut-off, corrections, history and presence or absence
Materials to obtain first
This root record is not a case of missing subclaim scores or parent inheritance. Original verification and path checks, B0, support and safety assessments are historical, not a completed current review. Original candidate pending/eligible states are also historical.
Further research
Link user materials and decisions to full original preservation and separate events.
Remaining uncertainty
Unread or unverified does not mean a zero effect, zero events, safety or new clinical certification
Conditions for verification
Original root verdict, Korean and English, cut-off, corrections, history and presence or absence
Why this condition is needed
An individual preparation condition recording the population, endpoint, denominator, period, efficacy, harm and report relationships of the existing native MAIN claim
Application exceptions
Do not use unread materials, other questions, institutions or periods, or out-of-scope outcomes as substitutes for meeting a condition, a zero effect or safety.
Referenced methods
Selected claim: Reduced thirty-day all-cause mortality in ST-elevation myocardial infarction

Related sources R01