Ordinary thiamine , single-ingredient oral use,
does it really help with Whether usual gait speed improves in older adults with objectively impaired physical function?
research showsWithin the search and access scope recorded through 2026-09-16, no directly eligible controlled human usual-gait-speed result was verified. The current value is ? / score null. This is not a finding of benefit, no effect, or no human research.
ads claimEnergy metabolism, less fatigue, grip strength, gait-instability symptoms or a formula result must not be relabeled as improved usual gait speed in older adults.
Four separate assessment dimensions
| Effect direction and size | Unknown |
|---|---|
| Evidence certainty | Not scored for the unverified direct comparison |
| Applicability | Question-level objectively impaired older adults; actual cutoff unverified |
| Safety | Caution, separate from efficacy |
No directly eligible controlled usual-gait-speed result was verified. The explicit current-value rule requires ?/null with downstream axes unscored. Native calculator rejects these nulls; its raw B suggestion is invalid and not adopted. No-human-study flag remains false.
Useful facts when choosing a product
- Verify ordinary thiamine base, hydrochloride and mononitrate separately, including molecular form and dose.
- Benfotiamine, fursultiamine/TTFD, sulbutiamine, allithiamine, combinations and injections are not pooled as direct evidence for this oral single-ingredient question.
- Study exposures are not personal dosing recommendations.
Chamgap Semantic Classification Code
Permanent code issued
S.thiamine.oral-single-ingredient-form-dose-duration-unverified.older-objectively-impaired-usual-gait-speed.improve.placebo-no-added-thiamine-matched-careSubstances > Ordinary thiamine (vitamin B1) > Oral single ingredient with form/dose/duration unverified > Usual gait speed in objectively impaired older adults > Improvement > Placebo, no added thiamine or matched care
The current value is ? with a null score. Other heart-failure outcomes, formula gait results and observational associations are not treated as a direct usual-gait-speed effect of single-ingredient thiamine. The code identifies the intervention and claim; it never contains the evidence grade, score, or safety result.
Exact Claim Classification
These independent facets prevent evidence from different forms, routes, populations, effects, and comparators from being mixed.
| Intervention class | S · Supplement or nutraceutical |
|---|---|
| Canonical ingredient or intervention | Ordinary thiamine (vitamin B1), single ingredient; derivatives excluded |
| Source or part used | Manufactured ingredient; exact source/product unverified |
| Formulation or processing | Ordinary thiamine base, hydrochloride or mononitrate considered separately; no eligible exact form verified |
| Route | oral |
| Dose | Unverified: no selected eligible comparison |
| Duration | Unverified: no selected eligible comparison |
| Population | Older adults with objectively documented physical-function impairment; actual age/tool/cutoff unverified |
| Effect or condition | Improvement of usual gait speed |
| Primary endpoint | Usual/preferred gait speed, m/s; distance, protocol and principal time unverified |
| Comparator | Placebo, no added thiamine, or otherwise matched usual care; actual comparator unverified |
| Duplicate-detection key | S|thiamine|oral-single-ingredient-form-dose-duration-unverified|older-objectively-impaired-adults|usual-gait-speed-improvement|placebo-no-added-thiamine-matched-care |
What the research actually shows
The new HF family, CKD formula trial and nursing-home/hospital observational evidence were assessed. Prior 3117 strength/fatigue/neuropathy extractions were reused for boundaries only. No eligible comparison was selected; empirical dose, duration, gait distance and time remain unverified.
Why this is classified as ?
No directly eligible controlled usual-gait-speed result was verified. The explicit current-value rule requires ?/null with downstream axes unscored. Native calculator rejects these nulls; its raw B suggestion is invalid and not adopted. No-human-study flag remains false.
Counterpoint. The formula trial’s +0.07 m/s is a within-intervention median change, not a between-group thiamine effect. Its IQR of −0.02 to 0.22 m/s is not a confidence interval. [S05]
Rejudgment record. No directly eligible result verified — Current-value rule; native-calculator null-schema exception disclosed
Review performed and remaining limitations
No eligible numerical result verified; full-text/table/registry-history limits; actual dose/protocol unlocked
Preliminary RoB 2-informed review — not a complete formal assessment
| Randomization | No directly eligible trial selected; indirect studies reviewed separately |
|---|---|
| Deviations from assigned interventions | No directly eligible trial selected; indirect studies reviewed separately |
| Missing outcome data | No directly eligible trial selected; indirect studies reviewed separately |
| Outcome measurement | No directly eligible trial selected; indirect studies reviewed separately |
| Selection of the reported result | No directly eligible trial selected; indirect studies reviewed separately |
Reasons for the certainty judgment — not formal GRADE
| Risk of bias | Unscored without a verified direct comparison |
|---|---|
| Inconsistency | Unscored without a verified direct comparison |
| Indirectness | Unscored without a verified direct comparison |
| Imprecision | Unscored without a verified direct comparison |
| Publication bias | Unscored without a verified direct comparison |
Search scope and limitations. 43 general-web queries distinguished from unsuccessful native searches.
Evidence Table
| Study | Design | Sample | Funding | Endpoint | Result | Weight |
|---|---|---|---|---|---|---|
| Wong et al. 2022, THIAMINE-HF crossover trial in older adults with heart failure | Randomized double-blind placebo-controlled two-period crossover pilot in 24 participants | 24 randomized, 19 completed; 12 per sequence | Public and institutional funding with donated active and placebo products; not decisive eligible evidence | Recruitment feasibility was primary; usual gait speed was not measured | Oral thiamine mononitrate 500 mg/day was given for 90 days per period, but no objective impairment cutoff or usual-gait-speed result was available for target grading. | A nearby single-ingredient oral trial, but indirect because population and endpoint boundaries do not match |
| Yang et al. 2023, low-protein multicomponent formula trial in older adults with CKD | Open-label randomized parallel nutritional trial; 66 randomized and 47 analyzed | 24 intervention and 23 control participants analyzed | Reported funding and conflict information is preserved in the package audit | Usual 5-m gait speed in m/s; multicomponent formula plus low-protein diet versus diet alone | At three months the intervention-arm median change was +0.07 m/s (IQR −0.02 to 0.22), with between-group change-test P=0.009; this is not an isolated thiamine effect and the IQR is not a CI. | Excluded from target grading because the intervention was multicomponent and no required impairment cutoff was verified |
| Ito et al. 2012, thiamine status and nursing-care needs in elderly residents | Cross-sectional observational study of 74 nursing-home residents | 74 participants; 42 deficient and 32 nondeficient | Observational study without assigned treatment; not used for the decisive efficacy funding axis | Care level and ability to walk; not usual gait speed in m/s | Feeding route and care-level confounding prevent interpreting the association as a causal gait effect of thiamine supplementation. | Excluded because it was non-interventional and used a different endpoint |
| Pourhassan et al. 2019, thiamine status and functional recovery in hospitalized geriatric patients | Observational study of 233 participants; publisher-abstract access | 233 participants, mean age 82.1 years | Not a directly eligible intervention trial and not used for the decisive efficacy funding axis | Barthel Index functional recovery, not usual gait speed in m/s | The observed association between blood thiamine and function change was not interpreted as an oral-thiamine treatment effect. | Excluded because it was non-interventional and used a different endpoint |
Receipt — 19 References
Evidence access cutoff: 2026-09-16. Each citation states its actual access level (full-text transcription, abstract, index, or other) and remaining limitations. Bibliographic checking does not certify the study results or treatment efficacy.
Technical integration by: Codex · Evidence date: 2026-09-16 · Corrections: none
Cite this verdict
[Chamgap] Does thiamine improve usual gait speed in older adults with impaired physical function? — Evidence Grade ?. 19 cited sources checked. Source: https://chamgap.com/en/verdicts/sports/oral-thiamine-physically-impaired-older-adults-usual-gait-speed/ · CC BY 4.0CC BY 4.0 — free to use with attribution; do not distort grades, numbers, or verdict meaning.
What this document does and does not do
Chamgap is an information source. It reports what research has and has not confirmed; it does not tell readers what to take or buy. That decision belongs to readers and, when needed, medical or legal professionals. This verdict reflects literature available up to the search date and may change as new research appears. Nothing here is medical advice.