Dilute sodium-hypochlorite baths added to standard care × Improved itch, sleep, or quality of life

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionWhat are the selected patient-reported question and the parent verdict?Required	The selection concerns improved itch, sleep or quality of life, with original subclaim D. Its explanation retains sparse or uncertain patient-centered outcomes. Parent C50 concerns a different clinician-rated severity context. S01 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Original subclaim D, explanation and parent severity context	Material needed: The selection has no separate score, status or axes. Original structure and a separate change record are needed; missing fields are not filled with parent C50 or its assessment axes. This records needed materials; no new research was executed.
2	Unverified	Full text not readStored summary read	N02 · Evidence conditionAre findings known separately for itch, sleep and quality of life?Required	The selected Korean wording lists the outcomes together; the English wording says itch, sleep, or quality of life. The stored account describes patient-reported findings as difficult to judge. S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Measures, criteria and timing for each patient-reported outcome	Material needed: Measurement tools, findings, timing and original tables are needed for each outcome. One outcome is not converted into improvement in another. This records needed materials; no new research was executed.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionWho were the patient-reported populations and actual respondents?Required	The parent moderate-to-severe atopic-dermatitis scope and Hon's childhood-onset eczema bibliography are preserved. S01 S02 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Eligibility, age, severity and patient versus caregiver reporting	Material needed: Original trial materials are needed for outcome-specific populations, age, respondents and eligibility. Parent population descriptions do not substitute for outcome-specific respondent information. This records needed materials; no new research was executed.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionWere bathing products and formulations specified for the patient-reported trials?Required	The intervention is dilute sodium-hypochlorite bathing added to standard care. The stored explanation that products and concentrations are not interchangeable is retained. S01 S02 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Products, final concentrations, formulations and actual exposure	Material needed: Product specifications, concentrations, exposure and study manuals are needed for the patient-reported trials. No new dilution, procedural or treatment instructions are created. This records needed materials; no new research was executed.
5	Partly verified	Full text not readStored summary read	N05 · Evidence conditionHow are water-bath and usual-care controls distinguished?Required	The stored account describes comparisons with water bathing or usual care while standard treatment continued. S01 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Outcome-specific controls and shared bathing and care conditions	Material needed: Original materials are needed to map water controls, usual care and shared contact to each patient-reported outcome. Common bathing effects are not converted into ingredient-specific added effects. This records needed materials; no new research was executed.
6	Unverified	Full text not readStored summary read	N06 · Evidence conditionWhich tools and criteria were used to measure itch?Required	The review includes patient reports among its outcomes, while the stored account leaves itch findings uncertain. S01 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Itch measures, units, recall periods and meaningful change	Material needed: Itch tools, arm-specific values, changes, CIs, response criteria and original tables are needed. Affected-area SCORAD figures are not used as itch findings. This records needed materials; no new research was executed.
7	Unverified	Full text not readStored summary read	N07 · Evidence conditionAre sleep measures and observation windows known?Required	The selected question includes improved sleep, but the stored account retains uncertainty in patient-reported sleep findings. S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Sleep tools, recall periods, assessors and observation windows	Material needed: Sleep duration, quality, measures, arm-specific values, changes, CIs and objective measurement materials are needed. Itch or clinician-rated severity findings do not substitute for these data. This records needed materials; no new research was executed.
8	Unverified	Full text not readStored summary read	N08 · Evidence conditionAre quality-of-life tools and age-specific applications known?Required	The stored account describes quality-of-life findings as difficult to judge. S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Quality-of-life measures, respondents, baseline values and clinical importance	Material needed: Materials are needed to establish measures, age-specific applications, respondents, arm-specific estimates, CIs, missing responses and denominators. This records needed materials; no new research was executed.
9	Unverified	Full text not readStored summary read	N09 · Evidence conditionAre masking and expectation bias known for patient reports?Required	Hon is preserved as a double-blind crossover trial. This label is not transferred into masked patient reporting for every included trial. S01 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Respondent, assessor and analyst masking and sensory differences	Material needed: Trial-specific procedural records are needed for odor, irritation, expectations, masking success, proxy reporting and assessment roles. This records needed materials; no new research was executed.
10	Unverified	Full text not readStored summary read	N10 · Evidence conditionWas the prespecified hierarchy of each patient-reported outcome verified?Required	The stored account retains gaps in patient-reported materials and prespecified plans for favorable evidence. S01 S02 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Primary and secondary outcomes, changes, multiplicity and analysis plans	Material needed: Initial registrations, change histories, protocols, SAPs and multiplicity policies are needed for each outcome. Clinician-rated outcome hierarchy is not transferred to patient reports. This records needed materials; no new research was executed.
11	Unverified	Full text not readStored summary read	N11 · Evidence conditionAre analysis denominators and missing responses known for patient reports?Required	Hon's 40 completed and 14 nonadherent and the review's 10 trials and 307 participants are preserved in their original contexts. S01 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Response and analysis denominators by trial, outcome and time point	Material needed: These figures are not used as analysis denominators for each patient-reported outcome. Flow diagrams and original tables are needed for response counts, missingness, adjustments, ITT and PP. This records needed materials; no new research was executed.
12	Unverified	Full text not readStored summary read	N12 · Evidence conditionAre baseline, final and change values and analysis models known?Required	The wording that patient-centered findings were sparse or uncertain is preserved. S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Arm-specific baseline values, effects of interest, adjustment and repeated data	Material needed: Baseline, final and change values, adjusted estimates and repeated-data or crossover models are needed for each outcome. Missing fields are not filled with clinician-rated scores or colonization figures. This records needed materials; no new research was executed.
13	Unverified	Full text not readStored summary read	N13 · Evidence conditionAre the magnitude and precision of patient-experienced effects known?Required	Original subclaim D and its explanation retain sparse and uncertain patient-centered evidence. S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Direct between-arm effects, CIs, important change and sample plans	Material needed: Original estimates, CIs, clinical-importance criteria and sample plans are needed for each outcome. No new effect or CI is calculated and no meaningful improvement is established. This records needed materials; no new research was executed.
14	Partly verified	Full text not readStored summary read	N14 · Evidence conditionDoes the EASI signal establish patient-reported improvement?Required	EASI-50 22% versus 32% and ratio of means 0.78 (95% CrI 0.59 to 0.99) are preserved as pooled clinician-rated severity figures. S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Direct evidence distinguishing clinician ratings from patient reports	Material needed: Direct original tables are needed for itch, sleep and quality of life separately. These figures are not used as patient-reported effects, response rates or denominators. This records needed materials; no new research was executed.
15	Partly verified	Full text not readStored summary read	N15 · Evidence conditionWhich outcome does Hon's water-favoring finding concern?Required	Hon's no added benefit by ITT and affected-area change of water -5.7±15.4 versus bleach 0.6±12.4, P=.03, are preserved. S01	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Affected-area SCORAD versus patient-reported outcomes	Material needed: Measure definitions and direct patient-reported outcome tables are needed. The name SCORAD alone does not create itch or sleep component findings. This records needed materials; no new research was executed.
16	Partly verified	Full text not readStored summary read	N16 · Evidence conditionHow far is Wong's citation-only report linked?Required	Wong 2013 is preserved as a bibliography and summary of an Asian trial with concurrent treatment; there is no separate evidence row. S02	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Bibliography, concurrent care and direct patient-reported materials	Material needed: Originals are needed for design, denominators and itch, sleep and quality-of-life measures and findings. Bakaa evidence is not transferred to Wong. This records needed materials; no new research was executed.
17	Partly verified	Full text not readStored summary read	N17 · Evidence conditionWere shared reports and review size kept from independent double counting?Required	Hon, Wong and Bakaa are reports shared across existing questions. The review's 10 trials and 307 participants are a historical synthesis size and are not added to other participant counts. S01 S02 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Shared reports, trial families, review inclusion and overlap	Material needed: Patient-report inclusion tables, cohort links and original-trial materials are needed. Trial families, overlap, unique participants and independent-replication totals remain unverified. This records needed materials; no new research was executed.
18	Unverified	Full text not readStored summary read	N18 · Evidence conditionIs heterogeneity in formulations, controls and duration known?Required	The stored account explains that different concentrations, treatments, small samples and water-bath effects limit extension to patient-experienced benefit. S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Outcome-specific products, concentrations, concurrent care, controls and duration	Material needed: Outcome-specific included trials and comparable analyses are needed. Materials establishing independent replication under the same outcome and comparison conditions are not currently linked. This records needed materials; no new research was executed.
19	Unverified	Full text not readStored summary read	N19 · Evidence conditionAre duration and persistence known for each patient-reported outcome?Required	Parent wording of 4 weeks per period concerns the Hon crossover trial, while the parent 8-week trial narrative is preserved separately. S01 S02 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Outcome-specific observation windows, post-treatment periods and long-term follow-up	Material needed: Observation schedules, post-treatment and long-term materials are needed for each patient-reported outcome. Parent durations are not transferred into direct observation periods for every outcome. This records needed materials; no new research was executed.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionWere effects of standard care and antibiotics distinguished?Supplementary	The stored account records continued standard care and separates some antibiotic changes from effects of the ingredient alone. S01 S02 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Concurrent care, medication changes, adherence and patient reports	Material needed: Records are needed to map concurrent care, treatment changes and actual bathing to responses for each patient-reported outcome. This records needed materials; no new research was executed.
21	Partly verified	Full text not readStored summary read	N21 · Evidence conditionDo colonization or infection findings substitute for patient reports?Required	Colonization RR 0.89 (0.73 to 1.09) and uncertainty in clinical infection benefit are retained. Colonization and infection form another existing question. S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Boundaries among colonization, infection events and patient reports	Material needed: Direct original materials are needed for each outcome. Colonization or infection findings do not substitute for patient-reported improvement or an exact zero effect. This records needed materials; no new research was executed.
22	Partly verified	Full text not readStored summary read	N22 · Evidence conditionDoes sparse evidence establish an exactly null effect?Required	The original explanation records sparse or uncertain patient-centered outcomes. S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Missingness, uncertainty and the range that can be estimated	Material needed: Original estimates, denominators and reporting scope within materials actually read are needed. Sparse evidence does not establish exact zero effects, equivalence or absence of external reporting. This records needed materials; no new research was executed.
23	Unverified	Full text not readStored summary read	N23 · Evidence conditionWere Hon funding details distinguished from the parent public-funding wording?Required	Hon's unverified specific funding and COI and the parent wording describing a publicly funded water-controlled trial as a strength are both preserved. S01	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Funding, support, employee authors, COI and report mapping	Material needed: Original Hon support, author-affiliation and COI materials and source mapping for the parent wording are needed. Parent wording does not fill individual support fields as verified. This records needed materials; no new research was executed.
24	Partly verified	Full text not readStored summary read	N24 · Evidence conditionWere support for Wong, the review and original trials distinguished?Required	Wong has no individual funding row. Bakaa retains wording of academic or public investigators and no specific manufacturer support reported. S02 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Report-specific funding, product support, author roles and conflicts	Material needed: Support, author and COI documents are needed for each report and included trial. Review support is not transferred into verified support or independence for every original trial; Wong support also remains unverified. This records needed materials; no new research was executed.
25	Unverified	Full text not readStored summary read	N25 · Evidence conditionAre harm events and analysis denominators known?Supplementary	Review outcomes include adverse events, and the parent caution label is retained. S01 S02 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Harm definitions, arm-specific events, exposure, collection and withdrawals	Material needed: Original safety materials are needed for event counts, exposure, denominators, timing, missingness and withdrawals. Patient-experienced findings or caution wording do not create safety certification. This records needed materials; no new research was executed.
26	Unverified	Full text not readStored summary read	N26 · Evidence conditionAre long-term and vulnerable-group harms and use boundaries known?Supplementary	The parent caution wording is preserved. This table creates no dilution, treatment, procedural or new management instructions. S01 S02 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Populations, products, concurrent exposure and long-term harms	Material needed: Materials are needed for long-term and vulnerable-group risks, airway, eye and skin harms and alternative causes. These gaps are not filled with assertions of safety or suitability for use. This records needed materials; no new research was executed.
27	Partly verified	Full text not readStored summary read	N27 · Evidence conditionHow are existing verdicts, dates and missing-field structure retained?Required	Parent C50, the Korean and English narratives, assessment axes, 2026-09-07 and selected D with its explanation are retained. Empty correction and deliberation records and the absence of a separate subclaim score are also preserved. S01 S02 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Parent context, selected D, original evidence date and change history	Material needed: Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review, satisfied conditions or a new efficacy judgment. This records needed materials; no new research was executed.
28	Partly verified	Full text not readStored summary read	N28 · Evidence conditionWhich materials were actually read in this work?Required	Materials are prepared from stored JSON summaries and bibliography. Reading each stored report summary is distinguished from unread external originals. S01 S02 S03	Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.	Access states of stored summaries, bibliography and external materials	Material needed: External papers, registrations, protocols, SAPs and support originals remain unread with access not attempted. If additional material is supplied, actual reading scope and the update event must be recorded; links and historical checks are not promoted into current reading. This records needed materials; no new research was executed.

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28 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-09-07
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: The stored materials concern patient-reported outcomes in moderate-to-severe atopic dermatitis. Outcome-specific age, respondents, baseline status, eligibility and analysis denominators are unverified. Hon's 40 completed and 14 nonadherent and the review's 10 trials and 307 participants are parent-study contexts; they are not used as direct denominators for itch, sleep or quality of life or added into a new total.
Ingredient, formulation and route: The intervention is dilute sodium-hypochlorite bathing added to standard care. Exact mapping of products, final concentrations, formulations, exposure, adherence, emollients, topical treatment and antibiotic changes to patient-reported trials is unverified. Original product distinctions are retained without creating new dilution, treatment or procedural instructions.
Dose: The parent Hon schedule of 2 times per week and 4 weeks per period is retained only as a study record. The same exposure is not assumed for every patient-reported trial or outcome. Outcome-specific exposure, product specifications, adherence and quantitative doses are unverified and are not converted into personal-use instructions or an optimal dose.
Comparator: The stored account describes comparisons against water bathing or usual care while standard treatment continued. Exact controls, shared bathing, contact, care and simultaneous antibiotic mapping for each patient-reported outcome are unverified. Shared improvement is not converted into an effect of the ingredient alone, and different comparisons are not combined as one effect.
Measured outcome: The selection is improved itch, sleep or quality of life, retaining original subclaim D and its explanation of sparse or uncertain patient-centered findings. Outcome-specific measures, criteria, timing, direct effects, CIs, denominators and prespecified analyses are unverified. Parent C50 and clinician-rated EASI, EASI-50, SCORAD or colonization figures are not transferred into patient-reported effects; sparse evidence does not establish exact zero effects or equivalence.
Duration: Observation windows, post-treatment effects and long-term persistence are unverified for each patient-reported outcome. Parent Hon crossover periods of 4 weeks and the parent 8-week trial narrative are preserved as separate contexts and do not fill direct observation windows for itch, sleep or quality of life.
Questions outside this scope: Itch, sleep and quality of life are distinguished individually; one outcome is not used as improvement in another.; EASI, EASI-50, SCORAD, colonization and infection findings are not transferred into patient-reported effects, response rates or denominators.; Sparse evidence and unverified outcome-specific details do not establish exact zero effects, equivalence or absence of reporting across entire external originals.; Parent durations, samples, masking, support and review size are not automatically mapped into direct outcome-specific data or used to create new independent totals.; Original subclaim D is distinguished from parent C50 without creating new concentrations, dilution methods, procedural or treatment guidance, or safety certification.

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

S01 · Hon KL, Tsang YC, Lee VW, et al. Efficacy of sodium hypochlorite (bleach) baths to reduce Staphylococcus aureus colonization in childhood onset moderate-to-severe eczema: a randomized, placebo-controlled cross-over trial. J Dermatolog Treat. 2016;27:156-162. PMID: 26270469. DOI: 10.3109/09546634.2015.1067669.

PubMed

Material type: Stored report providing parent clinician-rated and water-control context
Materials actually read: Stored summary read; external materials unread
Findings recorded in the stored summary: No added bleach benefit by ITT; affected-area SCORAD change favored water, -5.7±15.4 versus 0.6±12.4, P=.03
Record level: Hon's 2016 water-controlled crossover trial provides parent clinician-rated severity context. It retains 40 completed, 14 nonadherent, no added benefit by ITT and affected-area change of water -5.7±15.4 versus bleach 0.6±12.4, P=.03. These findings do not create direct itch or sleep values or response denominators.
Study overlap and independent replication: Hon, Wong and Bakaa are preserved reports shared across existing questions. The review's 10 trials and 307 participants and Hon 40 completed are retained in their respective contexts and are not used as direct patient-report denominators or a new total. Outcome-specific review inclusion, overlap and unique trial, participant and independent-replication totals are unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
External paper	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
Protocol	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
Statistical analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
Funding, product support and COI material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.

S02 · Wong SM, Ng TG, Baba R. Efficacy and safety of sodium hypochlorite (bleach) baths in patients with moderate to severe atopic dermatitis in Malaysia. J Dermatol. 2013. PMID: 24111816. DOI: 10.1111/1346-8138.12265.

PubMed

Material type: Preserved bibliography and summary of a citation-only concurrent-care trial
Materials actually read: Stored summary read; external materials unread
Findings recorded in the stored summary: The stored citation summary separates an Asian trial with concurrent care.
Record level: Wong 2013 is a citation-only bibliography and summary of an Asian trial with concurrent care. A separate evidence row and direct patient-reported findings are not linked. Design, denominators, tools, timing and arm-specific effects are not filled with Bakaa materials or the parent 8-week narrative.
Study overlap and independent replication: Hon, Wong and Bakaa are preserved reports shared across existing questions. The review's 10 trials and 307 participants and Hon 40 completed are retained in their respective contexts and are not used as direct patient-report denominators or a new total. Outcome-specific review inclusion, overlap and unique trial, participant and independent-replication totals are unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
External paper	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
Protocol	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
Statistical analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
Funding, product support and COI material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.

S03 · Bakaa L, Pernica JM, Couban RJ, et al. Bleach baths for atopic dermatitis: a systematic review and meta-analysis including unpublished data, Bayesian interpretation, and GRADE. Ann Allergy Asthma Immunol. 2022;128:660-668.e9. PMID: 35367346. DOI: 10.1016/j.anai.2022.03.024.

PubMed

Material type: Review preserving sparse or uncertain selected patient-reported findings
Materials actually read: Stored summary read; external materials unread
Findings recorded in the stored summary: EASI-50 22% versus 32%; ratio of means 0.78 (95% CrI 0.59 to 0.99); colonization RR 0.89 (0.73 to 1.09)
Record level: Bakaa 2022's review of 10 trials and 307 participants is a synthesis size. Original sparse or uncertain patient-report wording is distinguished from clinician-rated EASI-50 22% versus 32%, ratio of means 0.78 (95% CrI 0.59 to 0.99) and colonization RR 0.89 (0.73 to 1.09). The review relates to the selected question, but tools, effects, CIs, denominators and timing for each patient report are not linked within the preserved scope.
Study overlap and independent replication: Hon, Wong and Bakaa are preserved reports shared across existing questions. The review's 10 trials and 307 participants and Hon 40 completed are retained in their respective contexts and are not used as direct patient-report denominators or a new total. Outcome-specific review inclusion, overlap and unique trial, participant and independent-replication totals are unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
External paper	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
Protocol	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
Statistical analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.
Funding, product support and COI material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date.

Report counts versus independent study counts

Hon, Wong and Bakaa are preserved reports shared across existing questions. The review's 10 trials and 307 participants and Hon 40 completed are retained in their respective contexts and are not used as direct patient-report denominators or a new total. Outcome-specific review inclusion, overlap and unique trial, participant and independent-replication totals are unverified.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · What are the selected patient-reported question and the parent verdict?

Required materials and conditions: Original subclaim D, explanation and parent severity context
Conditions for verification: Original material and analysis scope for Original subclaim D, explanation and parent severity context must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Original subclaim D, explanation and parent severity context with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N02 · Are findings known separately for itch, sleep and quality of life?

Required materials and conditions: Measures, criteria and timing for each patient-reported outcome
Conditions for verification: Original material and analysis scope for Measures, criteria and timing for each patient-reported outcome must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Measures, criteria and timing for each patient-reported outcome with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N03 · Who were the patient-reported populations and actual respondents?

Required materials and conditions: Eligibility, age, severity and patient versus caregiver reporting
Conditions for verification: Original material and analysis scope for Eligibility, age, severity and patient versus caregiver reporting must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Eligibility, age, severity and patient versus caregiver reporting with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N04 · Were bathing products and formulations specified for the patient-reported trials?

Required materials and conditions: Products, final concentrations, formulations and actual exposure
Conditions for verification: Original material and analysis scope for Products, final concentrations, formulations and actual exposure must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Products, final concentrations, formulations and actual exposure with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N05 · How are water-bath and usual-care controls distinguished?

Required materials and conditions: Outcome-specific controls and shared bathing and care conditions
Conditions for verification: Original material and analysis scope for Outcome-specific controls and shared bathing and care conditions must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Outcome-specific controls and shared bathing and care conditions with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N06 · Which tools and criteria were used to measure itch?

Required materials and conditions: Itch measures, units, recall periods and meaningful change
Conditions for verification: Original material and analysis scope for Itch measures, units, recall periods and meaningful change must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Itch measures, units, recall periods and meaningful change with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N07 · Are sleep measures and observation windows known?

Required materials and conditions: Sleep tools, recall periods, assessors and observation windows
Conditions for verification: Original material and analysis scope for Sleep tools, recall periods, assessors and observation windows must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Sleep tools, recall periods, assessors and observation windows with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N08 · Are quality-of-life tools and age-specific applications known?

Required materials and conditions: Quality-of-life measures, respondents, baseline values and clinical importance
Conditions for verification: Original material and analysis scope for Quality-of-life measures, respondents, baseline values and clinical importance must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Quality-of-life measures, respondents, baseline values and clinical importance with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N09 · Are masking and expectation bias known for patient reports?

Required materials and conditions: Respondent, assessor and analyst masking and sensory differences
Conditions for verification: Original material and analysis scope for Respondent, assessor and analyst masking and sensory differences must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Respondent, assessor and analyst masking and sensory differences with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N10 · Was the prespecified hierarchy of each patient-reported outcome verified?

Required materials and conditions: Primary and secondary outcomes, changes, multiplicity and analysis plans
Conditions for verification: Original material and analysis scope for Primary and secondary outcomes, changes, multiplicity and analysis plans must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Primary and secondary outcomes, changes, multiplicity and analysis plans with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N11 · Are analysis denominators and missing responses known for patient reports?

Required materials and conditions: Response and analysis denominators by trial, outcome and time point
Conditions for verification: Original material and analysis scope for Response and analysis denominators by trial, outcome and time point must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Response and analysis denominators by trial, outcome and time point with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N12 · Are baseline, final and change values and analysis models known?

Required materials and conditions: Arm-specific baseline values, effects of interest, adjustment and repeated data
Conditions for verification: Original material and analysis scope for Arm-specific baseline values, effects of interest, adjustment and repeated data must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Arm-specific baseline values, effects of interest, adjustment and repeated data with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N13 · Are the magnitude and precision of patient-experienced effects known?

Required materials and conditions: Direct between-arm effects, CIs, important change and sample plans
Conditions for verification: Original material and analysis scope for Direct between-arm effects, CIs, important change and sample plans must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Direct between-arm effects, CIs, important change and sample plans with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N14 · Does the EASI signal establish patient-reported improvement?

Required materials and conditions: Direct evidence distinguishing clinician ratings from patient reports
Conditions for verification: Original material and analysis scope for Direct evidence distinguishing clinician ratings from patient reports must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Direct evidence distinguishing clinician ratings from patient reports with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N15 · Which outcome does Hon's water-favoring finding concern?

Required materials and conditions: Affected-area SCORAD versus patient-reported outcomes
Conditions for verification: Original material and analysis scope for Affected-area SCORAD versus patient-reported outcomes must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Affected-area SCORAD versus patient-reported outcomes with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N16 · How far is Wong's citation-only report linked?

Required materials and conditions: Bibliography, concurrent care and direct patient-reported materials
Conditions for verification: Original material and analysis scope for Bibliography, concurrent care and direct patient-reported materials must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Bibliography, concurrent care and direct patient-reported materials with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N17 · Were shared reports and review size kept from independent double counting?

Required materials and conditions: Shared reports, trial families, review inclusion and overlap
Conditions for verification: Original material and analysis scope for Shared reports, trial families, review inclusion and overlap must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Shared reports, trial families, review inclusion and overlap with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N18 · Is heterogeneity in formulations, controls and duration known?

Required materials and conditions: Outcome-specific products, concentrations, concurrent care, controls and duration
Conditions for verification: Original material and analysis scope for Outcome-specific products, concentrations, concurrent care, controls and duration must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Outcome-specific products, concentrations, concurrent care, controls and duration with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N19 · Are duration and persistence known for each patient-reported outcome?

Required materials and conditions: Outcome-specific observation windows, post-treatment periods and long-term follow-up
Conditions for verification: Original material and analysis scope for Outcome-specific observation windows, post-treatment periods and long-term follow-up must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Outcome-specific observation windows, post-treatment periods and long-term follow-up with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N20 · Were effects of standard care and antibiotics distinguished?

Required materials and conditions: Concurrent care, medication changes, adherence and patient reports
Conditions for verification: Original material and analysis scope for Concurrent care, medication changes, adherence and patient reports must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Supplementary
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Concurrent care, medication changes, adherence and patient reports with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N21 · Do colonization or infection findings substitute for patient reports?

Required materials and conditions: Boundaries among colonization, infection events and patient reports
Conditions for verification: Original material and analysis scope for Boundaries among colonization, infection events and patient reports must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Boundaries among colonization, infection events and patient reports with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N22 · Does sparse evidence establish an exactly null effect?

Required materials and conditions: Missingness, uncertainty and the range that can be estimated
Conditions for verification: Original material and analysis scope for Missingness, uncertainty and the range that can be estimated must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Missingness, uncertainty and the range that can be estimated with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N23 · Were Hon funding details distinguished from the parent public-funding wording?

Required materials and conditions: Funding, support, employee authors, COI and report mapping
Conditions for verification: Original material and analysis scope for Funding, support, employee authors, COI and report mapping must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Funding, support, employee authors, COI and report mapping with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N24 · Were support for Wong, the review and original trials distinguished?

Required materials and conditions: Report-specific funding, product support, author roles and conflicts
Conditions for verification: Original material and analysis scope for Report-specific funding, product support, author roles and conflicts must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Report-specific funding, product support, author roles and conflicts with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N25 · Are harm events and analysis denominators known?

Required materials and conditions: Harm definitions, arm-specific events, exposure, collection and withdrawals
Conditions for verification: Original material and analysis scope for Harm definitions, arm-specific events, exposure, collection and withdrawals must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Supplementary
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Harm definitions, arm-specific events, exposure, collection and withdrawals with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N26 · Are long-term and vulnerable-group harms and use boundaries known?

Required materials and conditions: Populations, products, concurrent exposure and long-term harms
Conditions for verification: Original material and analysis scope for Populations, products, concurrent exposure and long-term harms must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Supplementary
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Populations, products, concurrent exposure and long-term harms with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N27 · How are existing verdicts, dates and missing-field structure retained?

Required materials and conditions: Parent context, selected D, original evidence date and change history
Conditions for verification: Original material and analysis scope for Parent context, selected D, original evidence date and change history must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Parent context, selected D, original evidence date and change history with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

N28 · Which materials were actually read in this work?

Required materials and conditions: Access states of stored summaries, bibliography and external materials
Conditions for verification: Original material and analysis scope for Access states of stored summaries, bibliography and external materials must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Access states of stored summaries, bibliography and external materials with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

What the statuses mean

Partly verified: Partial information from the stored summary is linked; detailed originals and content review remain incomplete.
Unverified: Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.
Review incomplete: Review of existing content remains incomplete.
Met: This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.
Not reported: Unreported within material actually read. Unread external material is not relabeled as unreported.
Inaccessible: This means actual access failure. External access was not attempted in this work, so this state was not assigned.
Not applicable: Used only with an application exception and reason based on the question scope.
Conflicting data: This requires actual comparison of materials; no new conflict judgment was made in this work.
Insufficient evidence for the conditions: This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade.

Change history

2026-10-19 · Public page/material version 1.0

Public-facing views and materials were prepared from the existing 28 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-09-07) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · What are the selected patient-reported question and the parent verdict?

Current findings: The selection concerns improved itch, sleep or quality of life, with original subclaim D. Its explanation retains sparse or uncertain patient-centered outcomes. Parent C50 concerns a different clinician-rated severity context.
Verification status: Partly verified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: The selection has no separate score, status or axes. Original structure and a separate change record are needed; missing fields are not filled with parent C50 or its assessment axes.
Required materials and conditions: Original subclaim D, explanation and parent severity context
Materials to obtain first: The selection has no separate score, status or axes. Original structure and a separate change record are needed; missing fields are not filled with parent C50 or its assessment axes.
Further research: Material needed: The selection has no separate score, status or axes. Original structure and a separate change record are needed; missing fields are not filled with parent C50 or its assessment axes. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Original subclaim D, explanation and parent severity context must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Original subclaim D, explanation and parent severity context with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S03

N02 · Are findings known separately for itch, sleep and quality of life?

Current findings: The selected Korean wording lists the outcomes together; the English wording says itch, sleep, or quality of life. The stored account describes patient-reported findings as difficult to judge.
Verification status: Unverified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Measurement tools, findings, timing and original tables are needed for each outcome. One outcome is not converted into improvement in another.
Required materials and conditions: Measures, criteria and timing for each patient-reported outcome
Materials to obtain first: Measurement tools, findings, timing and original tables are needed for each outcome. One outcome is not converted into improvement in another.
Further research: Material needed: Measurement tools, findings, timing and original tables are needed for each outcome. One outcome is not converted into improvement in another. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Measures, criteria and timing for each patient-reported outcome must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Measures, criteria and timing for each patient-reported outcome with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S03

N03 · Who were the patient-reported populations and actual respondents?

Current findings: The parent moderate-to-severe atopic-dermatitis scope and Hon's childhood-onset eczema bibliography are preserved.
Verification status: Partly verified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Original trial materials are needed for outcome-specific populations, age, respondents and eligibility. Parent population descriptions do not substitute for outcome-specific respondent information.
Required materials and conditions: Eligibility, age, severity and patient versus caregiver reporting
Materials to obtain first: Original trial materials are needed for outcome-specific populations, age, respondents and eligibility. Parent population descriptions do not substitute for outcome-specific respondent information.
Further research: Material needed: Original trial materials are needed for outcome-specific populations, age, respondents and eligibility. Parent population descriptions do not substitute for outcome-specific respondent information. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Eligibility, age, severity and patient versus caregiver reporting must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Eligibility, age, severity and patient versus caregiver reporting with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S02 S03

N04 · Were bathing products and formulations specified for the patient-reported trials?

Current findings: The intervention is dilute sodium-hypochlorite bathing added to standard care. The stored explanation that products and concentrations are not interchangeable is retained.
Verification status: Partly verified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Product specifications, concentrations, exposure and study manuals are needed for the patient-reported trials. No new dilution, procedural or treatment instructions are created.
Required materials and conditions: Products, final concentrations, formulations and actual exposure
Materials to obtain first: Product specifications, concentrations, exposure and study manuals are needed for the patient-reported trials. No new dilution, procedural or treatment instructions are created.
Further research: Material needed: Product specifications, concentrations, exposure and study manuals are needed for the patient-reported trials. No new dilution, procedural or treatment instructions are created. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Products, final concentrations, formulations and actual exposure must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Products, final concentrations, formulations and actual exposure with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S02 S03

N05 · How are water-bath and usual-care controls distinguished?

Current findings: The stored account describes comparisons with water bathing or usual care while standard treatment continued.
Verification status: Partly verified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Original materials are needed to map water controls, usual care and shared contact to each patient-reported outcome. Common bathing effects are not converted into ingredient-specific added effects.
Required materials and conditions: Outcome-specific controls and shared bathing and care conditions
Materials to obtain first: Original materials are needed to map water controls, usual care and shared contact to each patient-reported outcome. Common bathing effects are not converted into ingredient-specific added effects.
Further research: Material needed: Original materials are needed to map water controls, usual care and shared contact to each patient-reported outcome. Common bathing effects are not converted into ingredient-specific added effects. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Outcome-specific controls and shared bathing and care conditions must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Outcome-specific controls and shared bathing and care conditions with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S03

N06 · Which tools and criteria were used to measure itch?

Current findings: The review includes patient reports among its outcomes, while the stored account leaves itch findings uncertain.
Verification status: Unverified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Itch tools, arm-specific values, changes, CIs, response criteria and original tables are needed. Affected-area SCORAD figures are not used as itch findings.
Required materials and conditions: Itch measures, units, recall periods and meaningful change
Materials to obtain first: Itch tools, arm-specific values, changes, CIs, response criteria and original tables are needed. Affected-area SCORAD figures are not used as itch findings.
Further research: Material needed: Itch tools, arm-specific values, changes, CIs, response criteria and original tables are needed. Affected-area SCORAD figures are not used as itch findings. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Itch measures, units, recall periods and meaningful change must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Itch measures, units, recall periods and meaningful change with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S03

N07 · Are sleep measures and observation windows known?

Current findings: The selected question includes improved sleep, but the stored account retains uncertainty in patient-reported sleep findings.
Verification status: Unverified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Sleep duration, quality, measures, arm-specific values, changes, CIs and objective measurement materials are needed. Itch or clinician-rated severity findings do not substitute for these data.
Required materials and conditions: Sleep tools, recall periods, assessors and observation windows
Materials to obtain first: Sleep duration, quality, measures, arm-specific values, changes, CIs and objective measurement materials are needed. Itch or clinician-rated severity findings do not substitute for these data.
Further research: Material needed: Sleep duration, quality, measures, arm-specific values, changes, CIs and objective measurement materials are needed. Itch or clinician-rated severity findings do not substitute for these data. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Sleep tools, recall periods, assessors and observation windows must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Sleep tools, recall periods, assessors and observation windows with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S03

N08 · Are quality-of-life tools and age-specific applications known?

Current findings: The stored account describes quality-of-life findings as difficult to judge.
Verification status: Unverified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Materials are needed to establish measures, age-specific applications, respondents, arm-specific estimates, CIs, missing responses and denominators.
Required materials and conditions: Quality-of-life measures, respondents, baseline values and clinical importance
Materials to obtain first: Materials are needed to establish measures, age-specific applications, respondents, arm-specific estimates, CIs, missing responses and denominators.
Further research: Material needed: Materials are needed to establish measures, age-specific applications, respondents, arm-specific estimates, CIs, missing responses and denominators. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Quality-of-life measures, respondents, baseline values and clinical importance must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Quality-of-life measures, respondents, baseline values and clinical importance with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S03

N09 · Are masking and expectation bias known for patient reports?

Current findings: Hon is preserved as a double-blind crossover trial. This label is not transferred into masked patient reporting for every included trial.
Verification status: Unverified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Trial-specific procedural records are needed for odor, irritation, expectations, masking success, proxy reporting and assessment roles.
Required materials and conditions: Respondent, assessor and analyst masking and sensory differences
Materials to obtain first: Trial-specific procedural records are needed for odor, irritation, expectations, masking success, proxy reporting and assessment roles.
Further research: Material needed: Trial-specific procedural records are needed for odor, irritation, expectations, masking success, proxy reporting and assessment roles. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Respondent, assessor and analyst masking and sensory differences must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Respondent, assessor and analyst masking and sensory differences with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S03

N10 · Was the prespecified hierarchy of each patient-reported outcome verified?

Current findings: The stored account retains gaps in patient-reported materials and prespecified plans for favorable evidence.
Verification status: Unverified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Initial registrations, change histories, protocols, SAPs and multiplicity policies are needed for each outcome. Clinician-rated outcome hierarchy is not transferred to patient reports.
Required materials and conditions: Primary and secondary outcomes, changes, multiplicity and analysis plans
Materials to obtain first: Initial registrations, change histories, protocols, SAPs and multiplicity policies are needed for each outcome. Clinician-rated outcome hierarchy is not transferred to patient reports.
Further research: Material needed: Initial registrations, change histories, protocols, SAPs and multiplicity policies are needed for each outcome. Clinician-rated outcome hierarchy is not transferred to patient reports. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Primary and secondary outcomes, changes, multiplicity and analysis plans must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Primary and secondary outcomes, changes, multiplicity and analysis plans with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S02 S03

N11 · Are analysis denominators and missing responses known for patient reports?

Current findings: Hon's 40 completed and 14 nonadherent and the review's 10 trials and 307 participants are preserved in their original contexts.
Verification status: Unverified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: These figures are not used as analysis denominators for each patient-reported outcome. Flow diagrams and original tables are needed for response counts, missingness, adjustments, ITT and PP.
Required materials and conditions: Response and analysis denominators by trial, outcome and time point
Materials to obtain first: These figures are not used as analysis denominators for each patient-reported outcome. Flow diagrams and original tables are needed for response counts, missingness, adjustments, ITT and PP.
Further research: Material needed: These figures are not used as analysis denominators for each patient-reported outcome. Flow diagrams and original tables are needed for response counts, missingness, adjustments, ITT and PP. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Response and analysis denominators by trial, outcome and time point must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Response and analysis denominators by trial, outcome and time point with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S03

N12 · Are baseline, final and change values and analysis models known?

Current findings: The wording that patient-centered findings were sparse or uncertain is preserved.
Verification status: Unverified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Baseline, final and change values, adjusted estimates and repeated-data or crossover models are needed for each outcome. Missing fields are not filled with clinician-rated scores or colonization figures.
Required materials and conditions: Arm-specific baseline values, effects of interest, adjustment and repeated data
Materials to obtain first: Baseline, final and change values, adjusted estimates and repeated-data or crossover models are needed for each outcome. Missing fields are not filled with clinician-rated scores or colonization figures.
Further research: Material needed: Baseline, final and change values, adjusted estimates and repeated-data or crossover models are needed for each outcome. Missing fields are not filled with clinician-rated scores or colonization figures. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Arm-specific baseline values, effects of interest, adjustment and repeated data must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Arm-specific baseline values, effects of interest, adjustment and repeated data with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S03

N13 · Are the magnitude and precision of patient-experienced effects known?

Current findings: Original subclaim D and its explanation retain sparse and uncertain patient-centered evidence.
Verification status: Unverified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Original estimates, CIs, clinical-importance criteria and sample plans are needed for each outcome. No new effect or CI is calculated and no meaningful improvement is established.
Required materials and conditions: Direct between-arm effects, CIs, important change and sample plans
Materials to obtain first: Original estimates, CIs, clinical-importance criteria and sample plans are needed for each outcome. No new effect or CI is calculated and no meaningful improvement is established.
Further research: Material needed: Original estimates, CIs, clinical-importance criteria and sample plans are needed for each outcome. No new effect or CI is calculated and no meaningful improvement is established. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Direct between-arm effects, CIs, important change and sample plans must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Direct between-arm effects, CIs, important change and sample plans with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S03

N14 · Does the EASI signal establish patient-reported improvement?

Current findings: EASI-50 22% versus 32% and ratio of means 0.78 (95% CrI 0.59 to 0.99) are preserved as pooled clinician-rated severity figures.
Verification status: Partly verified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Direct original tables are needed for itch, sleep and quality of life separately. These figures are not used as patient-reported effects, response rates or denominators.
Required materials and conditions: Direct evidence distinguishing clinician ratings from patient reports
Materials to obtain first: Direct original tables are needed for itch, sleep and quality of life separately. These figures are not used as patient-reported effects, response rates or denominators.
Further research: Material needed: Direct original tables are needed for itch, sleep and quality of life separately. These figures are not used as patient-reported effects, response rates or denominators. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Direct evidence distinguishing clinician ratings from patient reports must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Direct evidence distinguishing clinician ratings from patient reports with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S03

N15 · Which outcome does Hon's water-favoring finding concern?

Current findings: Hon's no added benefit by ITT and affected-area change of water -5.7±15.4 versus bleach 0.6±12.4, P=.03, are preserved.
Verification status: Partly verified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Measure definitions and direct patient-reported outcome tables are needed. The name SCORAD alone does not create itch or sleep component findings.
Required materials and conditions: Affected-area SCORAD versus patient-reported outcomes
Materials to obtain first: Measure definitions and direct patient-reported outcome tables are needed. The name SCORAD alone does not create itch or sleep component findings.
Further research: Material needed: Measure definitions and direct patient-reported outcome tables are needed. The name SCORAD alone does not create itch or sleep component findings. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Affected-area SCORAD versus patient-reported outcomes must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Affected-area SCORAD versus patient-reported outcomes with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01

N16 · How far is Wong's citation-only report linked?

Current findings: Wong 2013 is preserved as a bibliography and summary of an Asian trial with concurrent treatment; there is no separate evidence row.
Verification status: Partly verified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Originals are needed for design, denominators and itch, sleep and quality-of-life measures and findings. Bakaa evidence is not transferred to Wong.
Required materials and conditions: Bibliography, concurrent care and direct patient-reported materials
Materials to obtain first: Originals are needed for design, denominators and itch, sleep and quality-of-life measures and findings. Bakaa evidence is not transferred to Wong.
Further research: Material needed: Originals are needed for design, denominators and itch, sleep and quality-of-life measures and findings. Bakaa evidence is not transferred to Wong. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Bibliography, concurrent care and direct patient-reported materials must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Bibliography, concurrent care and direct patient-reported materials with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S02

N17 · Were shared reports and review size kept from independent double counting?

Current findings: Hon, Wong and Bakaa are reports shared across existing questions. The review's 10 trials and 307 participants are a historical synthesis size and are not added to other participant counts.
Verification status: Partly verified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Patient-report inclusion tables, cohort links and original-trial materials are needed. Trial families, overlap, unique participants and independent-replication totals remain unverified.
Required materials and conditions: Shared reports, trial families, review inclusion and overlap
Materials to obtain first: Patient-report inclusion tables, cohort links and original-trial materials are needed. Trial families, overlap, unique participants and independent-replication totals remain unverified.
Further research: Material needed: Patient-report inclusion tables, cohort links and original-trial materials are needed. Trial families, overlap, unique participants and independent-replication totals remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Shared reports, trial families, review inclusion and overlap must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Shared reports, trial families, review inclusion and overlap with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S02 S03

N18 · Is heterogeneity in formulations, controls and duration known?

Current findings: The stored account explains that different concentrations, treatments, small samples and water-bath effects limit extension to patient-experienced benefit.
Verification status: Unverified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Outcome-specific included trials and comparable analyses are needed. Materials establishing independent replication under the same outcome and comparison conditions are not currently linked.
Required materials and conditions: Outcome-specific products, concentrations, concurrent care, controls and duration
Materials to obtain first: Outcome-specific included trials and comparable analyses are needed. Materials establishing independent replication under the same outcome and comparison conditions are not currently linked.
Further research: Material needed: Outcome-specific included trials and comparable analyses are needed. Materials establishing independent replication under the same outcome and comparison conditions are not currently linked. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Outcome-specific products, concentrations, concurrent care, controls and duration must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Outcome-specific products, concentrations, concurrent care, controls and duration with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S03

N19 · Are duration and persistence known for each patient-reported outcome?

Current findings: Parent wording of 4 weeks per period concerns the Hon crossover trial, while the parent 8-week trial narrative is preserved separately.
Verification status: Unverified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Observation schedules, post-treatment and long-term materials are needed for each patient-reported outcome. Parent durations are not transferred into direct observation periods for every outcome.
Required materials and conditions: Outcome-specific observation windows, post-treatment periods and long-term follow-up
Materials to obtain first: Observation schedules, post-treatment and long-term materials are needed for each patient-reported outcome. Parent durations are not transferred into direct observation periods for every outcome.
Further research: Material needed: Observation schedules, post-treatment and long-term materials are needed for each patient-reported outcome. Parent durations are not transferred into direct observation periods for every outcome. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Outcome-specific observation windows, post-treatment periods and long-term follow-up must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Outcome-specific observation windows, post-treatment periods and long-term follow-up with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S02 S03

N20 · Were effects of standard care and antibiotics distinguished?

Current findings: The stored account records continued standard care and separates some antibiotic changes from effects of the ingredient alone.
Verification status: Partly verified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Records are needed to map concurrent care, treatment changes and actual bathing to responses for each patient-reported outcome.
Required materials and conditions: Concurrent care, medication changes, adherence and patient reports
Materials to obtain first: Records are needed to map concurrent care, treatment changes and actual bathing to responses for each patient-reported outcome.
Further research: Material needed: Records are needed to map concurrent care, treatment changes and actual bathing to responses for each patient-reported outcome. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Concurrent care, medication changes, adherence and patient reports must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Concurrent care, medication changes, adherence and patient reports with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S02 S03

N21 · Do colonization or infection findings substitute for patient reports?

Current findings: Colonization RR 0.89 (0.73 to 1.09) and uncertainty in clinical infection benefit are retained. Colonization and infection form another existing question.
Verification status: Partly verified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Direct original materials are needed for each outcome. Colonization or infection findings do not substitute for patient-reported improvement or an exact zero effect.
Required materials and conditions: Boundaries among colonization, infection events and patient reports
Materials to obtain first: Direct original materials are needed for each outcome. Colonization or infection findings do not substitute for patient-reported improvement or an exact zero effect.
Further research: Material needed: Direct original materials are needed for each outcome. Colonization or infection findings do not substitute for patient-reported improvement or an exact zero effect. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Boundaries among colonization, infection events and patient reports must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Boundaries among colonization, infection events and patient reports with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S03

N22 · Does sparse evidence establish an exactly null effect?

Current findings: The original explanation records sparse or uncertain patient-centered outcomes.
Verification status: Partly verified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Original estimates, denominators and reporting scope within materials actually read are needed. Sparse evidence does not establish exact zero effects, equivalence or absence of external reporting.
Required materials and conditions: Missingness, uncertainty and the range that can be estimated
Materials to obtain first: Original estimates, denominators and reporting scope within materials actually read are needed. Sparse evidence does not establish exact zero effects, equivalence or absence of external reporting.
Further research: Material needed: Original estimates, denominators and reporting scope within materials actually read are needed. Sparse evidence does not establish exact zero effects, equivalence or absence of external reporting. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Missingness, uncertainty and the range that can be estimated must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Missingness, uncertainty and the range that can be estimated with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S03

N23 · Were Hon funding details distinguished from the parent public-funding wording?

Current findings: Hon's unverified specific funding and COI and the parent wording describing a publicly funded water-controlled trial as a strength are both preserved.
Verification status: Unverified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Original Hon support, author-affiliation and COI materials and source mapping for the parent wording are needed. Parent wording does not fill individual support fields as verified.
Required materials and conditions: Funding, support, employee authors, COI and report mapping
Materials to obtain first: Original Hon support, author-affiliation and COI materials and source mapping for the parent wording are needed. Parent wording does not fill individual support fields as verified.
Further research: Material needed: Original Hon support, author-affiliation and COI materials and source mapping for the parent wording are needed. Parent wording does not fill individual support fields as verified. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Funding, support, employee authors, COI and report mapping must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Funding, support, employee authors, COI and report mapping with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01

N24 · Were support for Wong, the review and original trials distinguished?

Current findings: Wong has no individual funding row. Bakaa retains wording of academic or public investigators and no specific manufacturer support reported.
Verification status: Partly verified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Support, author and COI documents are needed for each report and included trial. Review support is not transferred into verified support or independence for every original trial; Wong support also remains unverified.
Required materials and conditions: Report-specific funding, product support, author roles and conflicts
Materials to obtain first: Support, author and COI documents are needed for each report and included trial. Review support is not transferred into verified support or independence for every original trial; Wong support also remains unverified.
Further research: Material needed: Support, author and COI documents are needed for each report and included trial. Review support is not transferred into verified support or independence for every original trial; Wong support also remains unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Report-specific funding, product support, author roles and conflicts must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Report-specific funding, product support, author roles and conflicts with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S02 S03

N25 · Are harm events and analysis denominators known?

Current findings: Review outcomes include adverse events, and the parent caution label is retained.
Verification status: Unverified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Original safety materials are needed for event counts, exposure, denominators, timing, missingness and withdrawals. Patient-experienced findings or caution wording do not create safety certification.
Required materials and conditions: Harm definitions, arm-specific events, exposure, collection and withdrawals
Materials to obtain first: Original safety materials are needed for event counts, exposure, denominators, timing, missingness and withdrawals. Patient-experienced findings or caution wording do not create safety certification.
Further research: Material needed: Original safety materials are needed for event counts, exposure, denominators, timing, missingness and withdrawals. Patient-experienced findings or caution wording do not create safety certification. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Harm definitions, arm-specific events, exposure, collection and withdrawals must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Harm definitions, arm-specific events, exposure, collection and withdrawals with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S02 S03

N26 · Are long-term and vulnerable-group harms and use boundaries known?

Current findings: The parent caution wording is preserved. This table creates no dilution, treatment, procedural or new management instructions.
Verification status: Unverified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Materials are needed for long-term and vulnerable-group risks, airway, eye and skin harms and alternative causes. These gaps are not filled with assertions of safety or suitability for use.
Required materials and conditions: Populations, products, concurrent exposure and long-term harms
Materials to obtain first: Materials are needed for long-term and vulnerable-group risks, airway, eye and skin harms and alternative causes. These gaps are not filled with assertions of safety or suitability for use.
Further research: Material needed: Materials are needed for long-term and vulnerable-group risks, airway, eye and skin harms and alternative causes. These gaps are not filled with assertions of safety or suitability for use. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Populations, products, concurrent exposure and long-term harms must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Populations, products, concurrent exposure and long-term harms with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S02 S03

N27 · How are existing verdicts, dates and missing-field structure retained?

Current findings: Parent C50, the Korean and English narratives, assessment axes, 2026-09-07 and selected D with its explanation are retained. Empty correction and deliberation records and the absence of a separate subclaim score are also preserved.
Verification status: Partly verified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review, satisfied conditions or a new efficacy judgment.
Required materials and conditions: Parent context, selected D, original evidence date and change history
Materials to obtain first: Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review, satisfied conditions or a new efficacy judgment.
Further research: Material needed: Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review, satisfied conditions or a new efficacy judgment. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Parent context, selected D, original evidence date and change history must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Parent context, selected D, original evidence date and change history with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S02 S03

N28 · Which materials were actually read in this work?

Current findings: Materials are prepared from stored JSON summaries and bibliography. Reading each stored report summary is distinguished from unread external originals.
Verification status: Partly verified
Materials actually read: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread
Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.
Reason for missing information: External papers, registrations, protocols, SAPs and support originals remain unread with access not attempted. If additional material is supplied, actual reading scope and the update event must be recorded; links and historical checks are not promoted into current reading.
Required materials and conditions: Access states of stored summaries, bibliography and external materials
Materials to obtain first: External papers, registrations, protocols, SAPs and support originals remain unread with access not attempted. If additional material is supplied, actual reading scope and the update event must be recorded; links and historical checks are not promoted into current reading.
Further research: Material needed: External papers, registrations, protocols, SAPs and support originals remain unread with access not attempted. If additional material is supplied, actual reading scope and the update event must be recorded; links and historical checks are not promoted into current reading. This records needed materials; no new research was executed.
Remaining uncertainty: External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.
Conditions for verification: Original material and analysis scope for Access states of stored summaries, bibliography and external materials must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.
Why this condition is needed: This condition links Access states of stored summaries, bibliography and external materials with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.
Application exceptions: Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.

Related sources S01 S02 S03