{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Dilute sodium-hypochlorite baths added to standard care × Improved itch, sleep, or quality of life",
  "language": "en",
  "translation_date": "2026-10-19",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "What are the selected patient-reported question and the parent verdict?",
      "needed": "Original subclaim D, explanation and parent severity context",
      "role": "Required",
      "role_reason": "This condition links Original subclaim D, explanation and parent severity context with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Original subclaim D, explanation and parent severity context must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The selection has no separate score, status or axes. Original structure and a separate change record are needed; missing fields are not filled with parent C50 or its assessment axes. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Are findings known separately for itch, sleep and quality of life?",
      "needed": "Measures, criteria and timing for each patient-reported outcome",
      "role": "Required",
      "role_reason": "This condition links Measures, criteria and timing for each patient-reported outcome with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Measures, criteria and timing for each patient-reported outcome must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Measurement tools, findings, timing and original tables are needed for each outcome. One outcome is not converted into improvement in another. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Who were the patient-reported populations and actual respondents?",
      "needed": "Eligibility, age, severity and patient versus caregiver reporting",
      "role": "Required",
      "role_reason": "This condition links Eligibility, age, severity and patient versus caregiver reporting with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Eligibility, age, severity and patient versus caregiver reporting must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original trial materials are needed for outcome-specific populations, age, respondents and eligibility. Parent population descriptions do not substitute for outcome-specific respondent information. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Were bathing products and formulations specified for the patient-reported trials?",
      "needed": "Products, final concentrations, formulations and actual exposure",
      "role": "Required",
      "role_reason": "This condition links Products, final concentrations, formulations and actual exposure with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Products, final concentrations, formulations and actual exposure must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Product specifications, concentrations, exposure and study manuals are needed for the patient-reported trials. No new dilution, procedural or treatment instructions are created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "How are water-bath and usual-care controls distinguished?",
      "needed": "Outcome-specific controls and shared bathing and care conditions",
      "role": "Required",
      "role_reason": "This condition links Outcome-specific controls and shared bathing and care conditions with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Outcome-specific controls and shared bathing and care conditions must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original materials are needed to map water controls, usual care and shared contact to each patient-reported outcome. Common bathing effects are not converted into ingredient-specific added effects. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Which tools and criteria were used to measure itch?",
      "needed": "Itch measures, units, recall periods and meaningful change",
      "role": "Required",
      "role_reason": "This condition links Itch measures, units, recall periods and meaningful change with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Itch measures, units, recall periods and meaningful change must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Itch tools, arm-specific values, changes, CIs, response criteria and original tables are needed. Affected-area SCORAD figures are not used as itch findings. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Are sleep measures and observation windows known?",
      "needed": "Sleep tools, recall periods, assessors and observation windows",
      "role": "Required",
      "role_reason": "This condition links Sleep tools, recall periods, assessors and observation windows with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Sleep tools, recall periods, assessors and observation windows must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Sleep duration, quality, measures, arm-specific values, changes, CIs and objective measurement materials are needed. Itch or clinician-rated severity findings do not substitute for these data. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Are quality-of-life tools and age-specific applications known?",
      "needed": "Quality-of-life measures, respondents, baseline values and clinical importance",
      "role": "Required",
      "role_reason": "This condition links Quality-of-life measures, respondents, baseline values and clinical importance with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Quality-of-life measures, respondents, baseline values and clinical importance must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Materials are needed to establish measures, age-specific applications, respondents, arm-specific estimates, CIs, missing responses and denominators. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Are masking and expectation bias known for patient reports?",
      "needed": "Respondent, assessor and analyst masking and sensory differences",
      "role": "Required",
      "role_reason": "This condition links Respondent, assessor and analyst masking and sensory differences with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Respondent, assessor and analyst masking and sensory differences must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Trial-specific procedural records are needed for odor, irritation, expectations, masking success, proxy reporting and assessment roles. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Was the prespecified hierarchy of each patient-reported outcome verified?",
      "needed": "Primary and secondary outcomes, changes, multiplicity and analysis plans",
      "role": "Required",
      "role_reason": "This condition links Primary and secondary outcomes, changes, multiplicity and analysis plans with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Primary and secondary outcomes, changes, multiplicity and analysis plans must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Initial registrations, change histories, protocols, SAPs and multiplicity policies are needed for each outcome. Clinician-rated outcome hierarchy is not transferred to patient reports. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Are analysis denominators and missing responses known for patient reports?",
      "needed": "Response and analysis denominators by trial, outcome and time point",
      "role": "Required",
      "role_reason": "This condition links Response and analysis denominators by trial, outcome and time point with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Response and analysis denominators by trial, outcome and time point must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: These figures are not used as analysis denominators for each patient-reported outcome. Flow diagrams and original tables are needed for response counts, missingness, adjustments, ITT and PP. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Are baseline, final and change values and analysis models known?",
      "needed": "Arm-specific baseline values, effects of interest, adjustment and repeated data",
      "role": "Required",
      "role_reason": "This condition links Arm-specific baseline values, effects of interest, adjustment and repeated data with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Arm-specific baseline values, effects of interest, adjustment and repeated data must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Baseline, final and change values, adjusted estimates and repeated-data or crossover models are needed for each outcome. Missing fields are not filled with clinician-rated scores or colonization figures. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Are the magnitude and precision of patient-experienced effects known?",
      "needed": "Direct between-arm effects, CIs, important change and sample plans",
      "role": "Required",
      "role_reason": "This condition links Direct between-arm effects, CIs, important change and sample plans with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Direct between-arm effects, CIs, important change and sample plans must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original estimates, CIs, clinical-importance criteria and sample plans are needed for each outcome. No new effect or CI is calculated and no meaningful improvement is established. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Does the EASI signal establish patient-reported improvement?",
      "needed": "Direct evidence distinguishing clinician ratings from patient reports",
      "role": "Required",
      "role_reason": "This condition links Direct evidence distinguishing clinician ratings from patient reports with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Direct evidence distinguishing clinician ratings from patient reports must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct original tables are needed for itch, sleep and quality of life separately. These figures are not used as patient-reported effects, response rates or denominators. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Which outcome does Hon's water-favoring finding concern?",
      "needed": "Affected-area SCORAD versus patient-reported outcomes",
      "role": "Required",
      "role_reason": "This condition links Affected-area SCORAD versus patient-reported outcomes with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Affected-area SCORAD versus patient-reported outcomes must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Measure definitions and direct patient-reported outcome tables are needed. The name SCORAD alone does not create itch or sleep component findings. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "How far is Wong's citation-only report linked?",
      "needed": "Bibliography, concurrent care and direct patient-reported materials",
      "role": "Required",
      "role_reason": "This condition links Bibliography, concurrent care and direct patient-reported materials with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Bibliography, concurrent care and direct patient-reported materials must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Originals are needed for design, denominators and itch, sleep and quality-of-life measures and findings. Bakaa evidence is not transferred to Wong. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Were shared reports and review size kept from independent double counting?",
      "needed": "Shared reports, trial families, review inclusion and overlap",
      "role": "Required",
      "role_reason": "This condition links Shared reports, trial families, review inclusion and overlap with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Shared reports, trial families, review inclusion and overlap must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Patient-report inclusion tables, cohort links and original-trial materials are needed. Trial families, overlap, unique participants and independent-replication totals remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Is heterogeneity in formulations, controls and duration known?",
      "needed": "Outcome-specific products, concentrations, concurrent care, controls and duration",
      "role": "Required",
      "role_reason": "This condition links Outcome-specific products, concentrations, concurrent care, controls and duration with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Outcome-specific products, concentrations, concurrent care, controls and duration must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Outcome-specific included trials and comparable analyses are needed. Materials establishing independent replication under the same outcome and comparison conditions are not currently linked. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Are duration and persistence known for each patient-reported outcome?",
      "needed": "Outcome-specific observation windows, post-treatment periods and long-term follow-up",
      "role": "Required",
      "role_reason": "This condition links Outcome-specific observation windows, post-treatment periods and long-term follow-up with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Outcome-specific observation windows, post-treatment periods and long-term follow-up must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Observation schedules, post-treatment and long-term materials are needed for each patient-reported outcome. Parent durations are not transferred into direct observation periods for every outcome. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Were effects of standard care and antibiotics distinguished?",
      "needed": "Concurrent care, medication changes, adherence and patient reports",
      "role": "Supplementary",
      "role_reason": "This condition links Concurrent care, medication changes, adherence and patient reports with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Concurrent care, medication changes, adherence and patient reports must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Records are needed to map concurrent care, treatment changes and actual bathing to responses for each patient-reported outcome. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Do colonization or infection findings substitute for patient reports?",
      "needed": "Boundaries among colonization, infection events and patient reports",
      "role": "Required",
      "role_reason": "This condition links Boundaries among colonization, infection events and patient reports with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Boundaries among colonization, infection events and patient reports must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct original materials are needed for each outcome. Colonization or infection findings do not substitute for patient-reported improvement or an exact zero effect. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Does sparse evidence establish an exactly null effect?",
      "needed": "Missingness, uncertainty and the range that can be estimated",
      "role": "Required",
      "role_reason": "This condition links Missingness, uncertainty and the range that can be estimated with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Missingness, uncertainty and the range that can be estimated must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original estimates, denominators and reporting scope within materials actually read are needed. Sparse evidence does not establish exact zero effects, equivalence or absence of external reporting. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Were Hon funding details distinguished from the parent public-funding wording?",
      "needed": "Funding, support, employee authors, COI and report mapping",
      "role": "Required",
      "role_reason": "This condition links Funding, support, employee authors, COI and report mapping with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Funding, support, employee authors, COI and report mapping must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original Hon support, author-affiliation and COI materials and source mapping for the parent wording are needed. Parent wording does not fill individual support fields as verified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Were support for Wong, the review and original trials distinguished?",
      "needed": "Report-specific funding, product support, author roles and conflicts",
      "role": "Required",
      "role_reason": "This condition links Report-specific funding, product support, author roles and conflicts with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Report-specific funding, product support, author roles and conflicts must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Support, author and COI documents are needed for each report and included trial. Review support is not transferred into verified support or independence for every original trial; Wong support also remains unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Are harm events and analysis denominators known?",
      "needed": "Harm definitions, arm-specific events, exposure, collection and withdrawals",
      "role": "Supplementary",
      "role_reason": "This condition links Harm definitions, arm-specific events, exposure, collection and withdrawals with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Harm definitions, arm-specific events, exposure, collection and withdrawals must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original safety materials are needed for event counts, exposure, denominators, timing, missingness and withdrawals. Patient-experienced findings or caution wording do not create safety certification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are long-term and vulnerable-group harms and use boundaries known?",
      "needed": "Populations, products, concurrent exposure and long-term harms",
      "role": "Supplementary",
      "role_reason": "This condition links Populations, products, concurrent exposure and long-term harms with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Populations, products, concurrent exposure and long-term harms must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Materials are needed for long-term and vulnerable-group risks, airway, eye and skin harms and alternative causes. These gaps are not filled with assertions of safety or suitability for use. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "How are existing verdicts, dates and missing-field structure retained?",
      "needed": "Parent context, selected D, original evidence date and change history",
      "role": "Required",
      "role_reason": "This condition links Parent context, selected D, original evidence date and change history with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Parent context, selected D, original evidence date and change history must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review, satisfied conditions or a new efficacy judgment. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Which materials were actually read in this work?",
      "needed": "Access states of stored summaries, bibliography and external materials",
      "role": "Required",
      "role_reason": "This condition links Access states of stored summaries, bibliography and external materials with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Access states of stored summaries, bibliography and external materials must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: External papers, registrations, protocols, SAPs and support originals remain unread with access not attempted. If additional material is supplied, actual reading scope and the update event must be recorded; links and historical checks are not promoted into current reading. This records needed materials; no new research was executed."
    }
  ]
}