{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3008-s1", "verdict_number": "3008", "title": "Dilute sodium-hypochlorite baths added to standard care × Improved itch, sleep, or quality of life", "view_version": "1.0", "view_created_date": "2026-10-19", "criteria_version": "1.0", "criteria_date": "2026-10-06", "review_date": null, "legacy_evidence_date": "2026-09-07", "review_scope": { "materials_read": "Existing review summaries and stored records of methodological application", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.", "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature." }, "claim_context": { "population": "The stored materials concern patient-reported outcomes in moderate-to-severe atopic dermatitis. Outcome-specific age, respondents, baseline status, eligibility and analysis denominators are unverified. Hon's 40 completed and 14 nonadherent and the review's 10 trials and 307 participants are parent-study contexts; they are not used as direct denominators for itch, sleep or quality of life or added into a new total.", "intervention": "The intervention is dilute sodium-hypochlorite bathing added to standard care. Exact mapping of products, final concentrations, formulations, exposure, adherence, emollients, topical treatment and antibiotic changes to patient-reported trials is unverified. Original product distinctions are retained without creating new dilution, treatment or procedural instructions.", "dose": "The parent Hon schedule of 2 times per week and 4 weeks per period is retained only as a study record. The same exposure is not assumed for every patient-reported trial or outcome. Outcome-specific exposure, product specifications, adherence and quantitative doses are unverified and are not converted into personal-use instructions or an optimal dose.", "comparator": "The stored account describes comparisons against water bathing or usual care while standard treatment continued. Exact controls, shared bathing, contact, care and simultaneous antibiotic mapping for each patient-reported outcome are unverified. Shared improvement is not converted into an effect of the ingredient alone, and different comparisons are not combined as one effect.", "endpoint": "The selection is improved itch, sleep or quality of life, retaining original subclaim D and its explanation of sparse or uncertain patient-centered findings. Outcome-specific measures, criteria, timing, direct effects, CIs, denominators and prespecified analyses are unverified. Parent C50 and clinician-rated EASI, EASI-50, SCORAD or colonization figures are not transferred into patient-reported effects; sparse evidence does not establish exact zero effects or equivalence.", "duration": "Observation windows, post-treatment effects and long-term persistence are unverified for each patient-reported outcome. Parent Hon crossover periods of 4 weeks and the parent 8-week trial narrative are preserved as separate contexts and do not fill direct observation windows for itch, sleep or quality of life.", "excluded_extensions": [ "Itch, sleep and quality of life are distinguished individually; one outcome is not used as improvement in another.", "EASI, EASI-50, SCORAD, colonization and infection findings are not transferred into patient-reported effects, response rates or denominators.", "Sparse evidence and unverified outcome-specific details do not establish exact zero effects, equivalence or absence of reporting across entire external originals.", "Parent durations, samples, masking, support and review size are not automatically mapped into direct outcome-specific data or used to create new independent totals.", "Original subclaim D is distinguished from parent C50 without creating new concentrations, dilution methods, procedural or treatment guidance, or safety certification." ] }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "What are the selected patient-reported question and the parent verdict?", "needed": "Original subclaim D, explanation and parent severity context", "role": "Required", "role_reason": "This condition links Original subclaim D, explanation and parent severity context with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Original subclaim D, explanation and parent severity context must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The selection has no separate score, status or axes. Original structure and a separate change record are needed; missing fields are not filled with parent C50 or its assessment axes. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The selection concerns improved itch, sleep or quality of life, with original subclaim D. Its explanation retains sparse or uncertain patient-centered outcomes. Parent C50 concerns a different clinician-rated severity context.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "The selection has no separate score, status or axes. Original structure and a separate change record are needed; missing fields are not filled with parent C50 or its assessment axes.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The selection has no separate score, status or axes. Original structure and a separate change record are needed; missing fields are not filled with parent C50 or its assessment axes." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "Are findings known separately for itch, sleep and quality of life?", "needed": "Measures, criteria and timing for each patient-reported outcome", "role": "Required", "role_reason": "This condition links Measures, criteria and timing for each patient-reported outcome with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Measures, criteria and timing for each patient-reported outcome must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Measurement tools, findings, timing and original tables are needed for each outcome. One outcome is not converted into improvement in another. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The selected Korean wording lists the outcomes together; the English wording says itch, sleep, or quality of life. The stored account describes patient-reported findings as difficult to judge.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Measurement tools, findings, timing and original tables are needed for each outcome. One outcome is not converted into improvement in another.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Measurement tools, findings, timing and original tables are needed for each outcome. One outcome is not converted into improvement in another." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "Who were the patient-reported populations and actual respondents?", "needed": "Eligibility, age, severity and patient versus caregiver reporting", "role": "Required", "role_reason": "This condition links Eligibility, age, severity and patient versus caregiver reporting with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Eligibility, age, severity and patient versus caregiver reporting must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original trial materials are needed for outcome-specific populations, age, respondents and eligibility. Parent population descriptions do not substitute for outcome-specific respondent information. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The parent moderate-to-severe atopic-dermatitis scope and Hon's childhood-onset eczema bibliography are preserved.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original trial materials are needed for outcome-specific populations, age, respondents and eligibility. Parent population descriptions do not substitute for outcome-specific respondent information.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original trial materials are needed for outcome-specific populations, age, respondents and eligibility. Parent population descriptions do not substitute for outcome-specific respondent information." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "Were bathing products and formulations specified for the patient-reported trials?", "needed": "Products, final concentrations, formulations and actual exposure", "role": "Required", "role_reason": "This condition links Products, final concentrations, formulations and actual exposure with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Products, final concentrations, formulations and actual exposure must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Product specifications, concentrations, exposure and study manuals are needed for the patient-reported trials. No new dilution, procedural or treatment instructions are created. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The intervention is dilute sodium-hypochlorite bathing added to standard care. The stored explanation that products and concentrations are not interchangeable is retained.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Product specifications, concentrations, exposure and study manuals are needed for the patient-reported trials. No new dilution, procedural or treatment instructions are created.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Product specifications, concentrations, exposure and study manuals are needed for the patient-reported trials. No new dilution, procedural or treatment instructions are created." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "How are water-bath and usual-care controls distinguished?", "needed": "Outcome-specific controls and shared bathing and care conditions", "role": "Required", "role_reason": "This condition links Outcome-specific controls and shared bathing and care conditions with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Outcome-specific controls and shared bathing and care conditions must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original materials are needed to map water controls, usual care and shared contact to each patient-reported outcome. Common bathing effects are not converted into ingredient-specific added effects. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The stored account describes comparisons with water bathing or usual care while standard treatment continued.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original materials are needed to map water controls, usual care and shared contact to each patient-reported outcome. Common bathing effects are not converted into ingredient-specific added effects.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original materials are needed to map water controls, usual care and shared contact to each patient-reported outcome. Common bathing effects are not converted into ingredient-specific added effects." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "Which tools and criteria were used to measure itch?", "needed": "Itch measures, units, recall periods and meaningful change", "role": "Required", "role_reason": "This condition links Itch measures, units, recall periods and meaningful change with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Itch measures, units, recall periods and meaningful change must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Itch tools, arm-specific values, changes, CIs, response criteria and original tables are needed. Affected-area SCORAD figures are not used as itch findings. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The review includes patient reports among its outcomes, while the stored account leaves itch findings uncertain.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Itch tools, arm-specific values, changes, CIs, response criteria and original tables are needed. Affected-area SCORAD figures are not used as itch findings.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Itch tools, arm-specific values, changes, CIs, response criteria and original tables are needed. Affected-area SCORAD figures are not used as itch findings." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "Are sleep measures and observation windows known?", "needed": "Sleep tools, recall periods, assessors and observation windows", "role": "Required", "role_reason": "This condition links Sleep tools, recall periods, assessors and observation windows with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Sleep tools, recall periods, assessors and observation windows must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Sleep duration, quality, measures, arm-specific values, changes, CIs and objective measurement materials are needed. Itch or clinician-rated severity findings do not substitute for these data. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The selected question includes improved sleep, but the stored account retains uncertainty in patient-reported sleep findings.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Sleep duration, quality, measures, arm-specific values, changes, CIs and objective measurement materials are needed. Itch or clinician-rated severity findings do not substitute for these data.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Sleep duration, quality, measures, arm-specific values, changes, CIs and objective measurement materials are needed. Itch or clinician-rated severity findings do not substitute for these data." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "Are quality-of-life tools and age-specific applications known?", "needed": "Quality-of-life measures, respondents, baseline values and clinical importance", "role": "Required", "role_reason": "This condition links Quality-of-life measures, respondents, baseline values and clinical importance with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Quality-of-life measures, respondents, baseline values and clinical importance must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Materials are needed to establish measures, age-specific applications, respondents, arm-specific estimates, CIs, missing responses and denominators. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The stored account describes quality-of-life findings as difficult to judge.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Materials are needed to establish measures, age-specific applications, respondents, arm-specific estimates, CIs, missing responses and denominators.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Materials are needed to establish measures, age-specific applications, respondents, arm-specific estimates, CIs, missing responses and denominators." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "Are masking and expectation bias known for patient reports?", "needed": "Respondent, assessor and analyst masking and sensory differences", "role": "Required", "role_reason": "This condition links Respondent, assessor and analyst masking and sensory differences with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Respondent, assessor and analyst masking and sensory differences must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Trial-specific procedural records are needed for odor, irritation, expectations, masking success, proxy reporting and assessment roles. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Hon is preserved as a double-blind crossover trial. This label is not transferred into masked patient reporting for every included trial.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Trial-specific procedural records are needed for odor, irritation, expectations, masking success, proxy reporting and assessment roles.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Trial-specific procedural records are needed for odor, irritation, expectations, masking success, proxy reporting and assessment roles." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "Was the prespecified hierarchy of each patient-reported outcome verified?", "needed": "Primary and secondary outcomes, changes, multiplicity and analysis plans", "role": "Required", "role_reason": "This condition links Primary and secondary outcomes, changes, multiplicity and analysis plans with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Primary and secondary outcomes, changes, multiplicity and analysis plans must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Initial registrations, change histories, protocols, SAPs and multiplicity policies are needed for each outcome. Clinician-rated outcome hierarchy is not transferred to patient reports. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The stored account retains gaps in patient-reported materials and prespecified plans for favorable evidence.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Initial registrations, change histories, protocols, SAPs and multiplicity policies are needed for each outcome. Clinician-rated outcome hierarchy is not transferred to patient reports.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Initial registrations, change histories, protocols, SAPs and multiplicity policies are needed for each outcome. Clinician-rated outcome hierarchy is not transferred to patient reports." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Are analysis denominators and missing responses known for patient reports?", "needed": "Response and analysis denominators by trial, outcome and time point", "role": "Required", "role_reason": "This condition links Response and analysis denominators by trial, outcome and time point with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Response and analysis denominators by trial, outcome and time point must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: These figures are not used as analysis denominators for each patient-reported outcome. Flow diagrams and original tables are needed for response counts, missingness, adjustments, ITT and PP. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Hon's 40 completed and 14 nonadherent and the review's 10 trials and 307 participants are preserved in their original contexts.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "These figures are not used as analysis denominators for each patient-reported outcome. Flow diagrams and original tables are needed for response counts, missingness, adjustments, ITT and PP.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "These figures are not used as analysis denominators for each patient-reported outcome. Flow diagrams and original tables are needed for response counts, missingness, adjustments, ITT and PP." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "Are baseline, final and change values and analysis models known?", "needed": "Arm-specific baseline values, effects of interest, adjustment and repeated data", "role": "Required", "role_reason": "This condition links Arm-specific baseline values, effects of interest, adjustment and repeated data with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Arm-specific baseline values, effects of interest, adjustment and repeated data must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Baseline, final and change values, adjusted estimates and repeated-data or crossover models are needed for each outcome. Missing fields are not filled with clinician-rated scores or colonization figures. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The wording that patient-centered findings were sparse or uncertain is preserved.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Baseline, final and change values, adjusted estimates and repeated-data or crossover models are needed for each outcome. Missing fields are not filled with clinician-rated scores or colonization figures.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Baseline, final and change values, adjusted estimates and repeated-data or crossover models are needed for each outcome. Missing fields are not filled with clinician-rated scores or colonization figures." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Are the magnitude and precision of patient-experienced effects known?", "needed": "Direct between-arm effects, CIs, important change and sample plans", "role": "Required", "role_reason": "This condition links Direct between-arm effects, CIs, important change and sample plans with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Direct between-arm effects, CIs, important change and sample plans must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original estimates, CIs, clinical-importance criteria and sample plans are needed for each outcome. No new effect or CI is calculated and no meaningful improvement is established. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Original subclaim D and its explanation retain sparse and uncertain patient-centered evidence.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original estimates, CIs, clinical-importance criteria and sample plans are needed for each outcome. No new effect or CI is calculated and no meaningful improvement is established.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original estimates, CIs, clinical-importance criteria and sample plans are needed for each outcome. No new effect or CI is calculated and no meaningful improvement is established." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "Does the EASI signal establish patient-reported improvement?", "needed": "Direct evidence distinguishing clinician ratings from patient reports", "role": "Required", "role_reason": "This condition links Direct evidence distinguishing clinician ratings from patient reports with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Direct evidence distinguishing clinician ratings from patient reports must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Direct original tables are needed for itch, sleep and quality of life separately. These figures are not used as patient-reported effects, response rates or denominators. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "EASI-50 22% versus 32% and ratio of means 0.78 (95% CrI 0.59 to 0.99) are preserved as pooled clinician-rated severity figures.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Direct original tables are needed for itch, sleep and quality of life separately. These figures are not used as patient-reported effects, response rates or denominators.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct original tables are needed for itch, sleep and quality of life separately. These figures are not used as patient-reported effects, response rates or denominators." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Which outcome does Hon's water-favoring finding concern?", "needed": "Affected-area SCORAD versus patient-reported outcomes", "role": "Required", "role_reason": "This condition links Affected-area SCORAD versus patient-reported outcomes with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Affected-area SCORAD versus patient-reported outcomes must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Measure definitions and direct patient-reported outcome tables are needed. The name SCORAD alone does not create itch or sleep component findings. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Hon's no added benefit by ITT and affected-area change of water -5.7±15.4 versus bleach 0.6±12.4, P=.03, are preserved.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Measure definitions and direct patient-reported outcome tables are needed. The name SCORAD alone does not create itch or sleep component findings.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Measure definitions and direct patient-reported outcome tables are needed. The name SCORAD alone does not create itch or sleep component findings." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "How far is Wong's citation-only report linked?", "needed": "Bibliography, concurrent care and direct patient-reported materials", "role": "Required", "role_reason": "This condition links Bibliography, concurrent care and direct patient-reported materials with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Bibliography, concurrent care and direct patient-reported materials must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Originals are needed for design, denominators and itch, sleep and quality-of-life measures and findings. Bakaa evidence is not transferred to Wong. This records needed materials; no new research was executed.", "current_reports": [ "S02" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Wong 2013 is preserved as a bibliography and summary of an Asian trial with concurrent treatment; there is no separate evidence row.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Originals are needed for design, denominators and itch, sleep and quality-of-life measures and findings. Bakaa evidence is not transferred to Wong.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Originals are needed for design, denominators and itch, sleep and quality-of-life measures and findings. Bakaa evidence is not transferred to Wong." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Were shared reports and review size kept from independent double counting?", "needed": "Shared reports, trial families, review inclusion and overlap", "role": "Required", "role_reason": "This condition links Shared reports, trial families, review inclusion and overlap with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Shared reports, trial families, review inclusion and overlap must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Patient-report inclusion tables, cohort links and original-trial materials are needed. Trial families, overlap, unique participants and independent-replication totals remain unverified. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Hon, Wong and Bakaa are reports shared across existing questions. The review's 10 trials and 307 participants are a historical synthesis size and are not added to other participant counts.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Patient-report inclusion tables, cohort links and original-trial materials are needed. Trial families, overlap, unique participants and independent-replication totals remain unverified.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Patient-report inclusion tables, cohort links and original-trial materials are needed. Trial families, overlap, unique participants and independent-replication totals remain unverified." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "Is heterogeneity in formulations, controls and duration known?", "needed": "Outcome-specific products, concentrations, concurrent care, controls and duration", "role": "Required", "role_reason": "This condition links Outcome-specific products, concentrations, concurrent care, controls and duration with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Outcome-specific products, concentrations, concurrent care, controls and duration must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Outcome-specific included trials and comparable analyses are needed. Materials establishing independent replication under the same outcome and comparison conditions are not currently linked. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The stored account explains that different concentrations, treatments, small samples and water-bath effects limit extension to patient-experienced benefit.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Outcome-specific included trials and comparable analyses are needed. Materials establishing independent replication under the same outcome and comparison conditions are not currently linked.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Outcome-specific included trials and comparable analyses are needed. Materials establishing independent replication under the same outcome and comparison conditions are not currently linked." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Are duration and persistence known for each patient-reported outcome?", "needed": "Outcome-specific observation windows, post-treatment periods and long-term follow-up", "role": "Required", "role_reason": "This condition links Outcome-specific observation windows, post-treatment periods and long-term follow-up with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Outcome-specific observation windows, post-treatment periods and long-term follow-up must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Observation schedules, post-treatment and long-term materials are needed for each patient-reported outcome. Parent durations are not transferred into direct observation periods for every outcome. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Parent wording of 4 weeks per period concerns the Hon crossover trial, while the parent 8-week trial narrative is preserved separately.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Observation schedules, post-treatment and long-term materials are needed for each patient-reported outcome. Parent durations are not transferred into direct observation periods for every outcome.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Observation schedules, post-treatment and long-term materials are needed for each patient-reported outcome. Parent durations are not transferred into direct observation periods for every outcome." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "Were effects of standard care and antibiotics distinguished?", "needed": "Concurrent care, medication changes, adherence and patient reports", "role": "Supplementary", "role_reason": "This condition links Concurrent care, medication changes, adherence and patient reports with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Concurrent care, medication changes, adherence and patient reports must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Records are needed to map concurrent care, treatment changes and actual bathing to responses for each patient-reported outcome. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The stored account records continued standard care and separates some antibiotic changes from effects of the ingredient alone.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Records are needed to map concurrent care, treatment changes and actual bathing to responses for each patient-reported outcome.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Records are needed to map concurrent care, treatment changes and actual bathing to responses for each patient-reported outcome." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "Do colonization or infection findings substitute for patient reports?", "needed": "Boundaries among colonization, infection events and patient reports", "role": "Required", "role_reason": "This condition links Boundaries among colonization, infection events and patient reports with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Boundaries among colonization, infection events and patient reports must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Direct original materials are needed for each outcome. Colonization or infection findings do not substitute for patient-reported improvement or an exact zero effect. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Colonization RR 0.89 (0.73 to 1.09) and uncertainty in clinical infection benefit are retained. Colonization and infection form another existing question.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Direct original materials are needed for each outcome. Colonization or infection findings do not substitute for patient-reported improvement or an exact zero effect.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct original materials are needed for each outcome. Colonization or infection findings do not substitute for patient-reported improvement or an exact zero effect." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "Does sparse evidence establish an exactly null effect?", "needed": "Missingness, uncertainty and the range that can be estimated", "role": "Required", "role_reason": "This condition links Missingness, uncertainty and the range that can be estimated with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Missingness, uncertainty and the range that can be estimated must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original estimates, denominators and reporting scope within materials actually read are needed. Sparse evidence does not establish exact zero effects, equivalence or absence of external reporting. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The original explanation records sparse or uncertain patient-centered outcomes.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original estimates, denominators and reporting scope within materials actually read are needed. Sparse evidence does not establish exact zero effects, equivalence or absence of external reporting.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original estimates, denominators and reporting scope within materials actually read are needed. Sparse evidence does not establish exact zero effects, equivalence or absence of external reporting." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "Were Hon funding details distinguished from the parent public-funding wording?", "needed": "Funding, support, employee authors, COI and report mapping", "role": "Required", "role_reason": "This condition links Funding, support, employee authors, COI and report mapping with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Funding, support, employee authors, COI and report mapping must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original Hon support, author-affiliation and COI materials and source mapping for the parent wording are needed. Parent wording does not fill individual support fields as verified. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Hon's unverified specific funding and COI and the parent wording describing a publicly funded water-controlled trial as a strength are both preserved.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original Hon support, author-affiliation and COI materials and source mapping for the parent wording are needed. Parent wording does not fill individual support fields as verified.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original Hon support, author-affiliation and COI materials and source mapping for the parent wording are needed. Parent wording does not fill individual support fields as verified." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Were support for Wong, the review and original trials distinguished?", "needed": "Report-specific funding, product support, author roles and conflicts", "role": "Required", "role_reason": "This condition links Report-specific funding, product support, author roles and conflicts with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Report-specific funding, product support, author roles and conflicts must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Support, author and COI documents are needed for each report and included trial. Review support is not transferred into verified support or independence for every original trial; Wong support also remains unverified. This records needed materials; no new research was executed.", "current_reports": [ "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Wong has no individual funding row. Bakaa retains wording of academic or public investigators and no specific manufacturer support reported.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Support, author and COI documents are needed for each report and included trial. Review support is not transferred into verified support or independence for every original trial; Wong support also remains unverified.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Support, author and COI documents are needed for each report and included trial. Review support is not transferred into verified support or independence for every original trial; Wong support also remains unverified." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "Are harm events and analysis denominators known?", "needed": "Harm definitions, arm-specific events, exposure, collection and withdrawals", "role": "Supplementary", "role_reason": "This condition links Harm definitions, arm-specific events, exposure, collection and withdrawals with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Harm definitions, arm-specific events, exposure, collection and withdrawals must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original safety materials are needed for event counts, exposure, denominators, timing, missingness and withdrawals. Patient-experienced findings or caution wording do not create safety certification. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Review outcomes include adverse events, and the parent caution label is retained.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original safety materials are needed for event counts, exposure, denominators, timing, missingness and withdrawals. Patient-experienced findings or caution wording do not create safety certification.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original safety materials are needed for event counts, exposure, denominators, timing, missingness and withdrawals. Patient-experienced findings or caution wording do not create safety certification." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "Are long-term and vulnerable-group harms and use boundaries known?", "needed": "Populations, products, concurrent exposure and long-term harms", "role": "Supplementary", "role_reason": "This condition links Populations, products, concurrent exposure and long-term harms with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Populations, products, concurrent exposure and long-term harms must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Materials are needed for long-term and vulnerable-group risks, airway, eye and skin harms and alternative causes. These gaps are not filled with assertions of safety or suitability for use. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The parent caution wording is preserved. This table creates no dilution, treatment, procedural or new management instructions.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Materials are needed for long-term and vulnerable-group risks, airway, eye and skin harms and alternative causes. These gaps are not filled with assertions of safety or suitability for use.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Materials are needed for long-term and vulnerable-group risks, airway, eye and skin harms and alternative causes. These gaps are not filled with assertions of safety or suitability for use." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "How are existing verdicts, dates and missing-field structure retained?", "needed": "Parent context, selected D, original evidence date and change history", "role": "Required", "role_reason": "This condition links Parent context, selected D, original evidence date and change history with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Parent context, selected D, original evidence date and change history must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review, satisfied conditions or a new efficacy judgment. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Parent C50, the Korean and English narratives, assessment axes, 2026-09-07 and selected D with its explanation are retained. Empty correction and deliberation records and the absence of a separate subclaim score are also preserved.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review, satisfied conditions or a new efficacy judgment.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review, satisfied conditions or a new efficacy judgment." }, { "item_id": "N28", "question_type": "Evidence condition", "question": "Which materials were actually read in this work?", "needed": "Access states of stored summaries, bibliography and external materials", "role": "Required", "role_reason": "This condition links Access states of stored summaries, bibliography and external materials with populations, respondents, tools, exposure, controls, denominators, timing, analyses, precision, support and harms for the selected itch, sleep or quality-of-life question.", "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or its axes. Distinguish itch, sleep and quality of life individually; do not fill them with EASI, EASI-50, SCORAD, colonization or infection figures. Parent denominators, durations, masking, support and review size are not converted into direct outcome-specific evidence. No new effects, CIs, independent totals, grades, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Access states of stored summaries, bibliography and external materials must be linked to measurement, between-arm comparisons, denominators and timing for each patient-reported outcome, distinguishing stored summaries, unverified details, clinician ratings versus patient reports and original trials versus reviews.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: External papers, registrations, protocols, SAPs and support originals remain unread with access not attempted. If additional material is supplied, actual reading scope and the update event must be recorded; links and historical checks are not promoted into current reading. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Materials are prepared from stored JSON summaries and bibliography. Reading each stored report summary is distinguished from unread external originals.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "External papers, registrations, protocols, SAPs and support originals remain unread with access not attempted. If additional material is supplied, actual reading scope and the update event must be recorded; links and historical checks are not promoted into current reading.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Original subclaim D and sparse or uncertain patient-centered findings are retained alongside outcome-specific gaps in tools, effects, CIs, denominators, missingness, masking, prespecified plans, support and harms. Signals for other outcomes and bibliography or design labels do not establish current patient-reported effects, exact null effects, independence or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "External papers, registrations, protocols, SAPs and support originals remain unread with access not attempted. If additional material is supplied, actual reading scope and the update event must be recorded; links and historical checks are not promoted into current reading." } ], "reports": [ { "report_id": "S01", "title": "Hon KL, Tsang YC, Lee VW, et al. Efficacy of sodium hypochlorite (bleach) baths to reduce Staphylococcus aureus colonization in childhood onset moderate-to-severe eczema: a randomized, placebo-controlled cross-over trial. J Dermatolog Treat. 2016;27:156-162. PMID: 26270469. DOI: 10.3109/09546634.2015.1067669.", "url": "https://pubmed.ncbi.nlm.nih.gov/26270469/", "report_type": "Stored report providing parent clinician-rated and water-control context", "existence": "The stored summary contains a bibliography; acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external materials unread", "study_family": "Report links shared by existing questions; outcome-specific inclusion, unique counts and independence unverified", "independent_replication": "Hon, Wong and Bakaa are preserved reports shared across existing questions. The review's 10 trials and 307 participants and Hon 40 completed are retained in their respective contexts and are not used as direct patient-report denominators or a new total. Outcome-specific review inclusion, overlap and unique trial, participant and independent-replication totals are unverified.", "observed_result": "No added bleach benefit by ITT; affected-area SCORAD change favored water, -5.7±15.4 versus 0.6±12.4, P=.03", "result_level": "Hon's 2016 water-controlled crossover trial provides parent clinician-rated severity context. It retains 40 completed, 14 nonadherent, no added benefit by ITT and affected-area change of water -5.7±15.4 versus bleach 0.6±12.4, P=.03. These findings do not create direct itch or sleep values or response denominators.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Funding, product support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/26270469/" } ] }, { "report_id": "S02", "title": "Wong SM, Ng TG, Baba R. Efficacy and safety of sodium hypochlorite (bleach) baths in patients with moderate to severe atopic dermatitis in Malaysia. J Dermatol. 2013. PMID: 24111816. DOI: 10.1111/1346-8138.12265.", "url": "https://pubmed.ncbi.nlm.nih.gov/24111816/", "report_type": "Preserved bibliography and summary of a citation-only concurrent-care trial", "existence": "The stored summary contains a bibliography; acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external materials unread", "study_family": "Report links shared by existing questions; outcome-specific inclusion, unique counts and independence unverified", "independent_replication": "Hon, Wong and Bakaa are preserved reports shared across existing questions. The review's 10 trials and 307 participants and Hon 40 completed are retained in their respective contexts and are not used as direct patient-report denominators or a new total. Outcome-specific review inclusion, overlap and unique trial, participant and independent-replication totals are unverified.", "observed_result": "The stored citation summary separates an Asian trial with concurrent care.", "result_level": "Wong 2013 is a citation-only bibliography and summary of an Asian trial with concurrent care. A separate evidence row and direct patient-reported findings are not linked. Design, denominators, tools, timing and arm-specific effects are not filled with Bakaa materials or the parent 8-week narrative.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Funding, product support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/24111816/" } ] }, { "report_id": "S03", "title": "Bakaa L, Pernica JM, Couban RJ, et al. Bleach baths for atopic dermatitis: a systematic review and meta-analysis including unpublished data, Bayesian interpretation, and GRADE. Ann Allergy Asthma Immunol. 2022;128:660-668.e9. PMID: 35367346. DOI: 10.1016/j.anai.2022.03.024.", "url": "https://pubmed.ncbi.nlm.nih.gov/35367346/", "report_type": "Review preserving sparse or uncertain selected patient-reported findings", "existence": "The stored summary contains a bibliography; acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external materials unread", "study_family": "Report links shared by existing questions; outcome-specific inclusion, unique counts and independence unverified", "independent_replication": "Hon, Wong and Bakaa are preserved reports shared across existing questions. The review's 10 trials and 307 participants and Hon 40 completed are retained in their respective contexts and are not used as direct patient-report denominators or a new total. Outcome-specific review inclusion, overlap and unique trial, participant and independent-replication totals are unverified.", "observed_result": "EASI-50 22% versus 32%; ratio of means 0.78 (95% CrI 0.59 to 0.99); colonization RR 0.89 (0.73 to 1.09)", "result_level": "Bakaa 2022's review of 10 trials and 307 participants is a synthesis size. Original sparse or uncertain patient-report wording is distinguished from clinician-rated EASI-50 22% versus 32%, ratio of means 0.78 (95% CrI 0.59 to 0.99) and colonization RR 0.89 (0.73 to 1.09). The review relates to the selected question, but tools, effects, CIs, denominators and timing for each patient report are not linked within the preserved scope.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Funding, product support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/35367346/" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.", "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.", "Review incomplete": "Review of existing content remains incomplete.", "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.", "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.", "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.", "Not applicable": "Used only with an application exception and reason based on the question scope.", "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.", "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade." }, "study_overlap": { "state": "Unverified", "unique_trial_count": null, "unique_participant_count": null, "reason": "Hon, Wong and Bakaa are preserved reports shared across existing questions. The review's 10 trials and 307 participants and Hon 40 completed are retained in their respective contexts and are not used as direct patient-report denominators or a new total. Outcome-specific review inclusion, overlap and unique trial, participant and independent-replication totals are unverified." }, "history": [ { "date": "2026-10-19", "kind": "Separation of public-facing pages and materials", "view_version": "1.0", "change": "Public-facing views and materials were prepared from the existing 28 items. No new clinical search, verification-status change or scoring was performed." } ], "language": "en", "translation_date": "2026-10-19" }