Dilute sodium-hypochlorite baths added to standard care × Reduced S. aureus colonization or infection

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionWhat is the original conclusion for the selected colonization and infection question?Required	The selection is reduced S. aureus colonization or infection, with original subclaim D. Its explanation of a null colonization RR and unestablished clinical infection benefit is retained, separately from clinician-rated severity and patient-report questions. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Original subclaim and distinction between colonization and infection	Material needed: Original trials, outcomes, denominators, effects and intervals are needed separately for colonization and infection. Linking the existing question does not certify new independence. This records needed materials; no new research was executed.
2	Partly verified	Full text not readStored summary read	N02 · Evidence conditionAre colonization and actual infection the same outcome?Required	The stored account distinguishes the S. aureus colonization RR from uncertain infection findings. Detection or colonization is not converted into reduced clinical infection occurrence or treatment needs. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Distinction between microbial colonization, infection events and clinical severity	Material needed: Definitions of culture, detection and colonization and separate clinical infection diagnoses, events, timing, collection methods and denominators are needed. This records needed materials; no new research was executed.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionWhat colonization RR and interval are preserved?Required	The colonization RR of 0.89 (0.73 to 1.09) from Bakaa and the parent explanation is preserved. The account that the interval includes 1 and the null colonization finding are retained without calculating an absolute reduction. R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Original material for the colonization relative effect and precision	Material needed: Original reporting is needed for colonization definitions, included trials, denominators, control risks, timing, synthesis methods and interval type. This records needed materials; no new research was executed.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionDoes a null colonization finding establish eradication or an exact zero effect?Required	The original null colonization conclusion is retained. It is not converted into established eradication or precise equivalence demonstrating that every effect is exactly 0. R01 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Distinction between nonsignificance, eradication and equivalence	Material needed: Direct colonization findings, intervals, clinical importance boundaries, denominators, tests and measurement methods are needed. No new eradication or equivalence judgment or interval calculation is made. This records needed materials; no new research was executed.
5	Unverified	Full text not readStored summary read	N05 · Evidence conditionAre direct clinical infection values and denominators known?Required	The existing account states that reduced clinical infection is unestablished. Original infection events, affected participants, arm-specific denominators, direct effects, CIs and durations are absent from the stored summary. The colonization RR is not copied as an infection RR. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Infection diagnoses, events, affected participants and observation windows	Material needed: Infection definitions, severity, recurrent events, medication and hospitalization needs, observation windows, denominators, effects and CIs are needed. Event or patient counts are not invented or added. This records needed materials; no new research was executed.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionAre antibiotic and standard-care effects distinguished?Required	The parent account says emollients and topical treatment continued and simultaneous antibiotic changes in some trials were separated from an effect of bleach alone. Wong's bibliographic summary also concerns concurrent care. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Attribution of concurrent care and the added ingredient effect	Material needed: Trial-specific antibiotics, emollients, topical medication, changes, infection-treatment criteria and outcome denominators are needed. Multicomponent treatment findings are not attributed to the ingredient alone. This records needed materials; no new research was executed.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionIs shared improvement from water bathing an added ingredient effect?Required	The original explanation that shared improvement with bathing, emollients and topical care is not an added ingredient effect is retained. Direct water-controlled and usual-care comparisons are not combined as the same effect. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Distinction between water controls, usual care and shared care	Material needed: Arm-specific bathing, treatment, contact, adherence, control conditions and direct between-arm colonization and infection findings are needed. This records needed materials; no new research was executed.
8	Partly verified	Full text not readStored summary read	N08 · Evidence conditionWhich outcome does Hon's water-controlled finding describe?Required	Hon's no added bleach benefit by ITT and affected-area SCORAD change of water -5.7±15.4 versus bleach 0.6±12.4, P=.03, are preserved. Affected-area values are not effects on colonization levels or infection events. R01	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Distinction between severity and colonization or infection findings	Material needed: Separate measurements, between-arm findings, denominators, hierarchies and CIs are needed for colonization, infection and SCORAD. Affected-area values and P are not transferred to microbial outcomes. This records needed materials; no new research was executed.
9	Partly verified	Full text not readStored summary read	N09 · Evidence conditionWhat analysis units do Hon's completion and nonadherence counts represent?Required	Hon's 40 completed, 14 nonadherent and the citation's 14/40 are preserved. The parent's 40-person crossover, 4 weeks per period and null ITT findings remain original contexts; nonadherence is not calculated as simple dropout. R01	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Crossover denominators, adherence, ITT and missingness	Material needed: Original material is needed for period-specific allocation, sequence, carryover, within-participant correlation, outcome denominators, nonadherence definitions, ITT and handling of missingness. This records needed materials; no new research was executed.
10	Partly verified	Full text not readStored summary read	N10 · Evidence conditionAre differences in products, concentrations, exposure and duration known?Required	The existing account distinguishes different concentrations and products, 4 weeks per period in the key crossover and a separate 8-week context. It does not provide an exact common concentration or exposure. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Trial-specific formulations, final concentrations and actual exposure	Material needed: Trial-specific products, final concentrations, concurrent care, actual exposure, adherence, timing and findings are needed. No new dilution or treatment instructions are created. This records needed materials; no new research was executed.
11	Partly verified	Full text not readStored summary read	N11 · Evidence conditionAre the population and colonization-sampling denominators known?Required	The parent concerns moderate-to-severe atopic dermatitis, and Hon's bibliography specifies childhood onset eczema. The 40 and 307 participants describe trial and review sizes respectively, rather than direct colonization or infection analysis denominators. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Disease eligibility, baseline colonization, infection and vulnerable groups	Material needed: Age, diagnoses, severity, baseline colonization and infection, sampling sites, treatment histories and arm-specific outcome denominators are needed. Findings are not extended to other populations or infection types. This records needed materials; no new research was executed.
12	Partly verified	Full text not readStored summary read	N12 · Evidence conditionIs the review's overall size the colonization-outcome denominator?Required	Bakaa's 10 randomized trials and 307 participants are preserved. They do not mean identical included trials and denominators for colonization, severity, patient reports and harms. The review is not counted as a new trial or additional participants. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Review size versus outcome-specific original trials and denominators	Material needed: Outcome-specific inclusion, exclusion, original trials, denominators, overlap, controls, concurrent care and synthesis methods are needed. Unique trial and participant totals remain unverified. This records needed materials; no new research was executed.
13	Partly verified	Full text not readStored summary read	N13 · Evidence conditionAre EASI figures being used as infection effects?Required	EASI-50 of 22% versus 32% and a ratio of means of 0.78 (95% CrI 0.59 to 0.99) concern severity. They are not identical colonization RRs or infection effects, and the CrI is not relabeled as another outcome's CI. R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Distinction between severity response, ratio of means, colonization and infection	Material needed: Materials linking outcomes, denominators, original interval types, prespecified analyses and controls are needed. Arm order is not inferred and absolute differences are not calculated. This records needed materials; no new research was executed.
14	Partly verified	Full text not readStored summary read	N14 · Evidence conditionAre patient reports distinguished from eradication and infection prevention?Required	The account says itch, sleep, quality-of-life and infection findings are difficult to judge. An objective severity signal does not establish patient-perceived benefit, eradication or infection prevention. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Directness of itch, sleep, quality-of-life and microbial findings	Material needed: Original findings, denominators, measurement windows, CIs and importance criteria are needed separately for patient reports, colonization and infection. This records needed materials; no new research was executed.
15	Partly verified	Full text not readStored summary read	N15 · Evidence conditionHow far is Wong's citation-only report linked?Required	Wong's citation is a bibliographic summary distinguishing an Asian trial with concurrent care. It lacks a separate evidence row, colonization or infection values and CIs. The parent's 8-week narrative is not established as an exact Wong finding. R02	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Distinction between concurrent-care bibliography and direct findings	Material needed: Original populations, interventions, concurrent care, durations, outcomes, denominators, effects, CIs, prespecified plans and report relationships are needed. This records needed materials; no new research was executed.
16	Partly verified	Full text not readStored summary read	N16 · Evidence conditionAre gaps in unpublished material and prespecified analyses retained?Required	Bakaa's title mentioning unpublished data, Bayesian interpretation and GRADE is preserved. The parent retains gaps in unpublished originals, exact net effects and prespecified primary outcomes; the title does not establish new acquisition or official certification. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Distinction between a review title and original-data acquisition or prespecification	Material needed: Unpublished-report identities, complete originals, registration, protocols, SAPs, prespecified outcomes, changes, denominators and original-trial attribution are needed. This records needed materials; no new research was executed.
17	Partly verified	Full text not readStored summary read	N17 · Evidence conditionIs independent replication verified for colonization and infection?Required	Null water-controlled findings and a small synthesized severity signal are both preserved. They do not newly certify independent replication for colonization or infection; parent R0 and I2 and shared reports are distinguished. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	The same question, formulation and comparator, and report or cohort relationships	Material needed: Links between original trials, institutions, recruitment, participants, registration, formulations, controls and outcomes, and findings for the same direct question are needed. This records needed materials; no new research was executed.
18	Partly verified	Full text not readStored summary read	N18 · Evidence conditionAre differences in funding, products, authors and company involvement preserved?Required	Hon's unverified specific funding and COI and the parent's public-funded water-control strength statement are both preserved. Bakaa's academic or public support and no specific manufacturer support reported do not resolve that difference. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Original support and design, analysis and publication roles	Material needed: Report-specific financial and product support, author affiliations, design, analysis and publication roles, and attribution of the parent funding statement are needed. This records needed materials; no new research was executed.
19	Partly verified	Full text not readStored summary read	N19 · Evidence conditionAre biases in colonization testing and infection collection known?Required	Hon is preserved as a double-blind crossover trial. Its design label does not verify detailed colonization methods, sites, assessors, missingness or infection collection. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Culture, assessor masking, missingness and selective reporting	Material needed: Original culture, sampling, repeated measurements, assessors, missingness, infection diagnoses, selected outcomes and timing are needed. No new official risk-of-bias assessment is performed. This records needed materials; no new research was executed.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionAre recolonization and long-term infection prevention verified?Required	The key crossover's 4 weeks per period and the parent's separate 8-week context are retained. Details of post-treatment recolonization, long-term infection, antibiotic needs and vulnerable groups are absent from the stored summary. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Post-treatment persistence, infection, antibiotic needs and follow-up	Material needed: Post-treatment follow-up, continuing care, colonization, infection, harms, exposure, denominators, effects and CIs are needed. Short-term severity findings are not extended to long-term prevention. This records needed materials; no new research was executed.
21	Partly verified	Full text not readStored summary read	N21 · Evidence conditionAre actual denominators for skin, eye and airway harms known?Supplementary	The parent's warnings about chemical burns and eye or airway irritation from high concentrations or undiluted products are preserved. Trial-specific harm events, affected participants, exposure, denominators and collection methods are absent from the stored summary. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Harm collection, exposure, withdrawal and vulnerable groups	Material needed: Original products, exposure, active collection, severity, timing, denominators, withdrawals and materials on children or vulnerable airways are needed. Missing numbers are not converted into safety. This records needed materials; no new research was executed.
22	Partly verified	Full text not readStored summary read	N22 · Evidence conditionIs this evidence table a dilution, bathing or medication-change guide?Supplementary	This table preserves the existing intervention, comparison and warnings. It does not create new dilution or bathing steps, frequencies, concentrations or changes to topical medication or antibiotics. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Boundary between evidence preservation and procedural or treatment instructions	Material needed: Treatment and procedural decisions are a separate scope. Medication-adjustment recommendations outside the account are not created without original materials and the required review. This records needed materials; no new research was executed.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionAre the original subclaim grade and parent score or axes distinguished?Required	The selected subclaim grade is D, without an individual score, status or axes. Parent C50, Caution and judgment axes remain separate contexts and do not fill absent subclaim values. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Subclaim D and absent individual score, status and axes	Material needed: Materials for reviewing parent and subclaim boundaries are needed. No new grades, scores, clinical statuses or independent certification are created. This records needed materials; no new research was executed.
24	Partly verified	Full text not readStored summary read	N24 · Evidence conditionAre stored summaries distinguished from new external reading?Required	The complete stored parent summary is used for production. Historical verification, separation and original-comparison wording remains historical and does not represent new reading of external abstracts, full texts, registration or plans. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Existing complete summary versus external abstracts, full texts, registration and plans	Material needed: Acquisition, actual reading and content review must be recorded separately. An identifier or link alone does not establish completed reading or review. This records needed materials; no new research was executed.
25	Partly verified	Full text not readStored summary read	N25 · Evidence conditionAre bilingual representative descriptions applied to every trial?Required	The complete parent Korean and English accounts are preserved. Representative populations, doses and outcomes are not automatically applied as identical denominators, exposure or effects across every report, arm and outcome. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Original scope of language, formulation, population, control and outcome	Material needed: Report-specific populations, formulations, controls, outcomes, timing and denominators need linking. No new external English comparison or correction review was performed. This records needed materials; no new research was executed.
26	Partly verified	Full text not readStored summary read	N26 · Evidence conditionAre report and material counts used as unique trials or quality scores?Required	Report links, stored summaries and external material entries form the table's structure. They are not acquired external papers, unique trials, participants, independent replications or quality scores; reports shared across questions are not added. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Distinction between preservation structure, clinical units and actual reading	Material needed: Original trial, report, recruitment and participant links and actual material-reading records are needed. Unique trial and participant totals remain unverified. This records needed materials; no new research was executed.
27	Partly verified	Full text not readStored summary read	N27 · Evidence conditionAre the original evidence date, corrections and production records distinguished?Required	The original evidence date of 2026-09-07 and empty correction and deliberation records are retained. Production time is not converted into a new evidence-verification date, and nonexistent corrections are not created. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Original evidence date and empty correction or deliberation records	Material needed: Additional material, revised conditions, applied observations and judgment changes are separate events. Complete originals and reasons for changes must be preserved and linked to the required content review. This records needed materials; no new research was executed.
28	Partly verified	Full text not readStored summary read	N28 · Evidence conditionHow are new materials and question changes linked?Required	Current originals, conditions and observations are preserved. This work is not a new clinical search, calculation or change to the original judgment; future materials need linking to the relevant comparisons, outcomes, denominators and report boundaries. R01 R02 R03	This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.	Distinction between condition revisions, material updates and judgment changes	Material needed: Complete originals, events, versions, reasons for changes and the required review must be recorded. New dilution, procedural, medication-change or treatment instructions are not written. This records needed materials; no new research was executed.

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28 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-09-07
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: The stored moderate-to-severe atopic-dermatitis scope is retained. Eligibility, baseline status, sampling sites, responses and analysis denominators are unverified for each colonization or infection outcome. Hon 40 completed and 14 nonadherent and the review 10 trials and 307 participants retain their respective contexts; they are not new independent totals or direct colonization or infection denominators.
Ingredient, formulation and route: The intervention is dilute sodium-hypochlorite bathing added to standard care. Exact trial-specific products, final concentrations, formulations, colonization sampling and concurrent care are unverified. No new dilution, procedural or medication-change instructions are created.
Dose: The parent Hon schedule of 2 times per week and 4 weeks per period is retained only as study context. Actual exposure, product specifications, adherence and quantitative doses are unverified for each colonization or infection outcome. Study records are not converted into personal-use instructions.
Comparator: Direct water-controlled and usual-care comparisons are distinguished; shared improvement under standard care is not converted into an added bleach-ingredient effect. Antibiotic changes in some trials remain separate contexts, and outcome-specific controls, concurrent care and adherence details are unverified.
Measured outcome: The selection is reduced S. aureus colonization or infection, retaining original subclaim D, a null colonization RR and unestablished clinical infection benefit. The colonization RR of 0.89 (0.73 to 1.09) is preserved without converting it into an infection effect, exact zero effect or equivalence. Direct infection values, CIs, denominators and observation windows are unverified.
Duration: The key crossover periods of 4 weeks and the parent separate 8-week context are preserved. Exact measurement times, observation windows, post-treatment recolonization and long-term prevention details are unverified separately for colonization and infection.
Questions outside this scope: Distinguish colonization detection, positivity, clinical infection events and severity findings.; Do not convert a null colonization RR into established eradication, exact zero effects or equivalence.; Do not extend clinician-rated severity or patient-report signals to infection prevention.; Do not use parent trial or review sizes and shared reports as new unique trial or participant totals.; Do not create new concentrations, dilution methods, bathing steps, medication changes or treatment instructions.

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

R01 · Hon KL, Tsang YC, Lee VW, et al. Efficacy of sodium hypochlorite (bleach) baths to reduce Staphylococcus aureus colonization in childhood onset moderate-to-severe eczema: a randomized, placebo-controlled cross-over trial. J Dermatolog Treat. 2016;27:156-162. PMID: 26270469. DOI: 10.3109/09546634.2015.1067669.

PubMed

Material type: Stored report providing same-water-control and severity context
Materials actually read: Stored summary read; external materials unread
Findings recorded in the stored summary: No added bleach benefit by ITT; affected-area SCORAD change favored water, -5.7±15.4 versus 0.6±12.4, P=.03
Record level: Hon provides the parent same-water-control and clinician-rated severity context. Its 40 completed, 14 nonadherent, no added benefit by ITT and affected-area change of water -5.7±15.4 versus bleach 0.6±12.4, P=.03, are preserved. The colonization question in the original bibliography is not converted into acquired colonization or infection effects and denominators.
Study overlap and independent replication: Hon, Wong and Bakaa are preserved reports shared across the parent and existing subclaims. Hon 40 completed and 14 nonadherent and the review 10 trials and 307 participants retain their original contexts; they are not direct colonization or infection denominators or independent totals. Unique trial, participant and independent-replication totals are unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.

R02 · Wong SM, Ng TG, Baba R. Efficacy and safety of sodium hypochlorite (bleach) baths in patients with moderate to severe atopic dermatitis in Malaysia. J Dermatol. 2013. PMID: 24111816. DOI: 10.1111/1346-8138.12265.

PubMed

Material type: Citation-only bibliography and summary of a concurrent-care trial
Materials actually read: Stored summary read; external materials unread
Findings recorded in the stored summary: The stored citation summary separates an Asian trial with concurrent care.
Record level: Wong is a citation-only bibliography and summary of an Asian trial with concurrent care. A separate evidence row and direct colonization or infection effects, CIs and denominators are not linked. The parent 8-week context or Bakaa materials do not fill these gaps.
Study overlap and independent replication: Hon, Wong and Bakaa are preserved reports shared across the parent and existing subclaims. Hon 40 completed and 14 nonadherent and the review 10 trials and 307 participants retain their original contexts; they are not direct colonization or infection denominators or independent totals. Unique trial, participant and independent-replication totals are unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.

R03 · Bakaa L, Pernica JM, Couban RJ, et al. Bleach baths for atopic dermatitis: a systematic review and meta-analysis including unpublished data, Bayesian interpretation, and GRADE. Ann Allergy Asthma Immunol. 2022;128:660-668.e9. PMID: 35367346. DOI: 10.1016/j.anai.2022.03.024.

PubMed

Material type: Review preserved with colonization distinguished from other outcomes
Materials actually read: Stored summary read; external materials unread
Findings recorded in the stored summary: EASI-50 22% versus 32%; ratio of means 0.78 (95% CrI 0.59 to 0.99); colonization RR 0.89 (0.73 to 1.09)
Record level: Bakaa 10 trials and 307 participants describe the full review. The colonization RR of 0.89 (0.73 to 1.09) and unestablished clinical infection benefit are retained. EASI-50 of 22% versus 32% and a ratio of means of 0.78 (95% CrI 0.59 to 0.99) provide separate severity context. Colonization interval type, outcome-specific denominators, direct infection values and unpublished-original details are unverified.
Study overlap and independent replication: Hon, Wong and Bakaa are preserved reports shared across the parent and existing subclaims. Hon 40 completed and 14 nonadherent and the review 10 trials and 307 participants retain their original contexts; they are not direct colonization or infection denominators or independent totals. Unique trial, participant and independent-replication totals are unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created.

Report counts versus independent study counts

Hon, Wong and Bakaa are preserved reports shared across the parent and existing subclaims. Hon 40 completed and 14 nonadherent and the review 10 trials and 307 participants retain their original contexts; they are not direct colonization or infection denominators or independent totals. Unique trial, participant and independent-replication totals are unverified.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · What is the original conclusion for the selected colonization and infection question?

Required materials and conditions: Original subclaim and distinction between colonization and infection
Conditions for verification: Original material for Original subclaim and distinction between colonization and infection must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Original subclaim and distinction between colonization and infection with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N02 · Are colonization and actual infection the same outcome?

Required materials and conditions: Distinction between microbial colonization, infection events and clinical severity
Conditions for verification: Original material for Distinction between microbial colonization, infection events and clinical severity must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Distinction between microbial colonization, infection events and clinical severity with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N03 · What colonization RR and interval are preserved?

Required materials and conditions: Original material for the colonization relative effect and precision
Conditions for verification: Original material for Original material for the colonization relative effect and precision must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Original material for the colonization relative effect and precision with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N04 · Does a null colonization finding establish eradication or an exact zero effect?

Required materials and conditions: Distinction between nonsignificance, eradication and equivalence
Conditions for verification: Original material for Distinction between nonsignificance, eradication and equivalence must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Distinction between nonsignificance, eradication and equivalence with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N05 · Are direct clinical infection values and denominators known?

Required materials and conditions: Infection diagnoses, events, affected participants and observation windows
Conditions for verification: Original material for Infection diagnoses, events, affected participants and observation windows must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Infection diagnoses, events, affected participants and observation windows with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N06 · Are antibiotic and standard-care effects distinguished?

Required materials and conditions: Attribution of concurrent care and the added ingredient effect
Conditions for verification: Original material for Attribution of concurrent care and the added ingredient effect must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Attribution of concurrent care and the added ingredient effect with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N07 · Is shared improvement from water bathing an added ingredient effect?

Required materials and conditions: Distinction between water controls, usual care and shared care
Conditions for verification: Original material for Distinction between water controls, usual care and shared care must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Distinction between water controls, usual care and shared care with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N08 · Which outcome does Hon's water-controlled finding describe?

Required materials and conditions: Distinction between severity and colonization or infection findings
Conditions for verification: Original material for Distinction between severity and colonization or infection findings must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Distinction between severity and colonization or infection findings with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N09 · What analysis units do Hon's completion and nonadherence counts represent?

Required materials and conditions: Crossover denominators, adherence, ITT and missingness
Conditions for verification: Original material for Crossover denominators, adherence, ITT and missingness must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Crossover denominators, adherence, ITT and missingness with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N10 · Are differences in products, concentrations, exposure and duration known?

Required materials and conditions: Trial-specific formulations, final concentrations and actual exposure
Conditions for verification: Original material for Trial-specific formulations, final concentrations and actual exposure must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Trial-specific formulations, final concentrations and actual exposure with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N11 · Are the population and colonization-sampling denominators known?

Required materials and conditions: Disease eligibility, baseline colonization, infection and vulnerable groups
Conditions for verification: Original material for Disease eligibility, baseline colonization, infection and vulnerable groups must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Disease eligibility, baseline colonization, infection and vulnerable groups with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N12 · Is the review's overall size the colonization-outcome denominator?

Required materials and conditions: Review size versus outcome-specific original trials and denominators
Conditions for verification: Original material for Review size versus outcome-specific original trials and denominators must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Review size versus outcome-specific original trials and denominators with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N13 · Are EASI figures being used as infection effects?

Required materials and conditions: Distinction between severity response, ratio of means, colonization and infection
Conditions for verification: Original material for Distinction between severity response, ratio of means, colonization and infection must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Distinction between severity response, ratio of means, colonization and infection with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N14 · Are patient reports distinguished from eradication and infection prevention?

Required materials and conditions: Directness of itch, sleep, quality-of-life and microbial findings
Conditions for verification: Original material for Directness of itch, sleep, quality-of-life and microbial findings must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Directness of itch, sleep, quality-of-life and microbial findings with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N15 · How far is Wong's citation-only report linked?

Required materials and conditions: Distinction between concurrent-care bibliography and direct findings
Conditions for verification: Original material for Distinction between concurrent-care bibliography and direct findings must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Distinction between concurrent-care bibliography and direct findings with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N16 · Are gaps in unpublished material and prespecified analyses retained?

Required materials and conditions: Distinction between a review title and original-data acquisition or prespecification
Conditions for verification: Original material for Distinction between a review title and original-data acquisition or prespecification must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Distinction between a review title and original-data acquisition or prespecification with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N17 · Is independent replication verified for colonization and infection?

Required materials and conditions: The same question, formulation and comparator, and report or cohort relationships
Conditions for verification: Original material for The same question, formulation and comparator, and report or cohort relationships must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links The same question, formulation and comparator, and report or cohort relationships with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N18 · Are differences in funding, products, authors and company involvement preserved?

Required materials and conditions: Original support and design, analysis and publication roles
Conditions for verification: Original material for Original support and design, analysis and publication roles must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Original support and design, analysis and publication roles with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N19 · Are biases in colonization testing and infection collection known?

Required materials and conditions: Culture, assessor masking, missingness and selective reporting
Conditions for verification: Original material for Culture, assessor masking, missingness and selective reporting must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Culture, assessor masking, missingness and selective reporting with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N20 · Are recolonization and long-term infection prevention verified?

Required materials and conditions: Post-treatment persistence, infection, antibiotic needs and follow-up
Conditions for verification: Original material for Post-treatment persistence, infection, antibiotic needs and follow-up must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Post-treatment persistence, infection, antibiotic needs and follow-up with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N21 · Are actual denominators for skin, eye and airway harms known?

Required materials and conditions: Harm collection, exposure, withdrawal and vulnerable groups
Conditions for verification: Original material for Harm collection, exposure, withdrawal and vulnerable groups must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Supplementary
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Harm collection, exposure, withdrawal and vulnerable groups with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N22 · Is this evidence table a dilution, bathing or medication-change guide?

Required materials and conditions: Boundary between evidence preservation and procedural or treatment instructions
Conditions for verification: Original material for Boundary between evidence preservation and procedural or treatment instructions must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Supplementary
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Boundary between evidence preservation and procedural or treatment instructions with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N23 · Are the original subclaim grade and parent score or axes distinguished?

Required materials and conditions: Subclaim D and absent individual score, status and axes
Conditions for verification: Original material for Subclaim D and absent individual score, status and axes must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Subclaim D and absent individual score, status and axes with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N24 · Are stored summaries distinguished from new external reading?

Required materials and conditions: Existing complete summary versus external abstracts, full texts, registration and plans
Conditions for verification: Original material for Existing complete summary versus external abstracts, full texts, registration and plans must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Existing complete summary versus external abstracts, full texts, registration and plans with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N25 · Are bilingual representative descriptions applied to every trial?

Required materials and conditions: Original scope of language, formulation, population, control and outcome
Conditions for verification: Original material for Original scope of language, formulation, population, control and outcome must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Original scope of language, formulation, population, control and outcome with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N26 · Are report and material counts used as unique trials or quality scores?

Required materials and conditions: Distinction between preservation structure, clinical units and actual reading
Conditions for verification: Original material for Distinction between preservation structure, clinical units and actual reading must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Distinction between preservation structure, clinical units and actual reading with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N27 · Are the original evidence date, corrections and production records distinguished?

Required materials and conditions: Original evidence date and empty correction or deliberation records
Conditions for verification: Original material for Original evidence date and empty correction or deliberation records must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Original evidence date and empty correction or deliberation records with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

N28 · How are new materials and question changes linked?

Required materials and conditions: Distinction between condition revisions, material updates and judgment changes
Conditions for verification: Original material for Distinction between condition revisions, material updates and judgment changes must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Requirement and applicability: Required
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Why this condition is needed: This condition links Distinction between condition revisions, material updates and judgment changes with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

What the statuses mean

Partly verified: Partial information from the stored summary is linked; detailed originals and content review remain incomplete.
Unverified: Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.
Review incomplete: Review of existing content remains incomplete.
Met: This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.
Not reported: Unreported within material actually read. Unread external material is not relabeled as unreported.
Inaccessible: This means actual access failure. External access was not attempted in this work, so this state was not assigned.
Not applicable: Used only with an application exception and reason based on the question scope.
Conflicting data: This requires actual comparison of materials; no new conflict judgment was made in this work.
Insufficient evidence for the conditions: This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade.

Change history

2026-10-20 · Public page/material version 1.0

Public-facing views and materials were prepared from the existing 28 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-09-07) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · What is the original conclusion for the selected colonization and infection question?

Current findings: The selection is reduced S. aureus colonization or infection, with original subclaim D. Its explanation of a null colonization RR and unestablished clinical infection benefit is retained, separately from clinician-rated severity and patient-report questions.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Original trials, outcomes, denominators, effects and intervals are needed separately for colonization and infection. Linking the existing question does not certify new independence.
Required materials and conditions: Original subclaim and distinction between colonization and infection
Materials to obtain first: Original trials, outcomes, denominators, effects and intervals are needed separately for colonization and infection. Linking the existing question does not certify new independence.
Further research: Material needed: Original trials, outcomes, denominators, effects and intervals are needed separately for colonization and infection. Linking the existing question does not certify new independence. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Original subclaim and distinction between colonization and infection must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Original subclaim and distinction between colonization and infection with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N02 · Are colonization and actual infection the same outcome?

Current findings: The stored account distinguishes the S. aureus colonization RR from uncertain infection findings. Detection or colonization is not converted into reduced clinical infection occurrence or treatment needs.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Definitions of culture, detection and colonization and separate clinical infection diagnoses, events, timing, collection methods and denominators are needed.
Required materials and conditions: Distinction between microbial colonization, infection events and clinical severity
Materials to obtain first: Definitions of culture, detection and colonization and separate clinical infection diagnoses, events, timing, collection methods and denominators are needed.
Further research: Material needed: Definitions of culture, detection and colonization and separate clinical infection diagnoses, events, timing, collection methods and denominators are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Distinction between microbial colonization, infection events and clinical severity must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Distinction between microbial colonization, infection events and clinical severity with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N03 · What colonization RR and interval are preserved?

Current findings: The colonization RR of 0.89 (0.73 to 1.09) from Bakaa and the parent explanation is preserved. The account that the interval includes 1 and the null colonization finding are retained without calculating an absolute reduction.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Original reporting is needed for colonization definitions, included trials, denominators, control risks, timing, synthesis methods and interval type.
Required materials and conditions: Original material for the colonization relative effect and precision
Materials to obtain first: Original reporting is needed for colonization definitions, included trials, denominators, control risks, timing, synthesis methods and interval type.
Further research: Material needed: Original reporting is needed for colonization definitions, included trials, denominators, control risks, timing, synthesis methods and interval type. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Original material for the colonization relative effect and precision must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Original material for the colonization relative effect and precision with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R03

N04 · Does a null colonization finding establish eradication or an exact zero effect?

Current findings: The original null colonization conclusion is retained. It is not converted into established eradication or precise equivalence demonstrating that every effect is exactly 0.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Direct colonization findings, intervals, clinical importance boundaries, denominators, tests and measurement methods are needed. No new eradication or equivalence judgment or interval calculation is made.
Required materials and conditions: Distinction between nonsignificance, eradication and equivalence
Materials to obtain first: Direct colonization findings, intervals, clinical importance boundaries, denominators, tests and measurement methods are needed. No new eradication or equivalence judgment or interval calculation is made.
Further research: Material needed: Direct colonization findings, intervals, clinical importance boundaries, denominators, tests and measurement methods are needed. No new eradication or equivalence judgment or interval calculation is made. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Distinction between nonsignificance, eradication and equivalence must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Distinction between nonsignificance, eradication and equivalence with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R03

N05 · Are direct clinical infection values and denominators known?

Current findings: The existing account states that reduced clinical infection is unestablished. Original infection events, affected participants, arm-specific denominators, direct effects, CIs and durations are absent from the stored summary. The colonization RR is not copied as an infection RR.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Infection definitions, severity, recurrent events, medication and hospitalization needs, observation windows, denominators, effects and CIs are needed. Event or patient counts are not invented or added.
Required materials and conditions: Infection diagnoses, events, affected participants and observation windows
Materials to obtain first: Infection definitions, severity, recurrent events, medication and hospitalization needs, observation windows, denominators, effects and CIs are needed. Event or patient counts are not invented or added.
Further research: Material needed: Infection definitions, severity, recurrent events, medication and hospitalization needs, observation windows, denominators, effects and CIs are needed. Event or patient counts are not invented or added. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Infection diagnoses, events, affected participants and observation windows must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Infection diagnoses, events, affected participants and observation windows with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N06 · Are antibiotic and standard-care effects distinguished?

Current findings: The parent account says emollients and topical treatment continued and simultaneous antibiotic changes in some trials were separated from an effect of bleach alone. Wong's bibliographic summary also concerns concurrent care.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Trial-specific antibiotics, emollients, topical medication, changes, infection-treatment criteria and outcome denominators are needed. Multicomponent treatment findings are not attributed to the ingredient alone.
Required materials and conditions: Attribution of concurrent care and the added ingredient effect
Materials to obtain first: Trial-specific antibiotics, emollients, topical medication, changes, infection-treatment criteria and outcome denominators are needed. Multicomponent treatment findings are not attributed to the ingredient alone.
Further research: Material needed: Trial-specific antibiotics, emollients, topical medication, changes, infection-treatment criteria and outcome denominators are needed. Multicomponent treatment findings are not attributed to the ingredient alone. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Attribution of concurrent care and the added ingredient effect must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Attribution of concurrent care and the added ingredient effect with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N07 · Is shared improvement from water bathing an added ingredient effect?

Current findings: The original explanation that shared improvement with bathing, emollients and topical care is not an added ingredient effect is retained. Direct water-controlled and usual-care comparisons are not combined as the same effect.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Arm-specific bathing, treatment, contact, adherence, control conditions and direct between-arm colonization and infection findings are needed.
Required materials and conditions: Distinction between water controls, usual care and shared care
Materials to obtain first: Arm-specific bathing, treatment, contact, adherence, control conditions and direct between-arm colonization and infection findings are needed.
Further research: Material needed: Arm-specific bathing, treatment, contact, adherence, control conditions and direct between-arm colonization and infection findings are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Distinction between water controls, usual care and shared care must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Distinction between water controls, usual care and shared care with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N08 · Which outcome does Hon's water-controlled finding describe?

Current findings: Hon's no added bleach benefit by ITT and affected-area SCORAD change of water -5.7±15.4 versus bleach 0.6±12.4, P=.03, are preserved. Affected-area values are not effects on colonization levels or infection events.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Separate measurements, between-arm findings, denominators, hierarchies and CIs are needed for colonization, infection and SCORAD. Affected-area values and P are not transferred to microbial outcomes.
Required materials and conditions: Distinction between severity and colonization or infection findings
Materials to obtain first: Separate measurements, between-arm findings, denominators, hierarchies and CIs are needed for colonization, infection and SCORAD. Affected-area values and P are not transferred to microbial outcomes.
Further research: Material needed: Separate measurements, between-arm findings, denominators, hierarchies and CIs are needed for colonization, infection and SCORAD. Affected-area values and P are not transferred to microbial outcomes. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Distinction between severity and colonization or infection findings must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Distinction between severity and colonization or infection findings with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01

N09 · What analysis units do Hon's completion and nonadherence counts represent?

Current findings: Hon's 40 completed, 14 nonadherent and the citation's 14/40 are preserved. The parent's 40-person crossover, 4 weeks per period and null ITT findings remain original contexts; nonadherence is not calculated as simple dropout.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Original material is needed for period-specific allocation, sequence, carryover, within-participant correlation, outcome denominators, nonadherence definitions, ITT and handling of missingness.
Required materials and conditions: Crossover denominators, adherence, ITT and missingness
Materials to obtain first: Original material is needed for period-specific allocation, sequence, carryover, within-participant correlation, outcome denominators, nonadherence definitions, ITT and handling of missingness.
Further research: Material needed: Original material is needed for period-specific allocation, sequence, carryover, within-participant correlation, outcome denominators, nonadherence definitions, ITT and handling of missingness. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Crossover denominators, adherence, ITT and missingness must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Crossover denominators, adherence, ITT and missingness with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01

N10 · Are differences in products, concentrations, exposure and duration known?

Current findings: The existing account distinguishes different concentrations and products, 4 weeks per period in the key crossover and a separate 8-week context. It does not provide an exact common concentration or exposure.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Trial-specific products, final concentrations, concurrent care, actual exposure, adherence, timing and findings are needed. No new dilution or treatment instructions are created.
Required materials and conditions: Trial-specific formulations, final concentrations and actual exposure
Materials to obtain first: Trial-specific products, final concentrations, concurrent care, actual exposure, adherence, timing and findings are needed. No new dilution or treatment instructions are created.
Further research: Material needed: Trial-specific products, final concentrations, concurrent care, actual exposure, adherence, timing and findings are needed. No new dilution or treatment instructions are created. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Trial-specific formulations, final concentrations and actual exposure must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Trial-specific formulations, final concentrations and actual exposure with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N11 · Are the population and colonization-sampling denominators known?

Current findings: The parent concerns moderate-to-severe atopic dermatitis, and Hon's bibliography specifies childhood onset eczema. The 40 and 307 participants describe trial and review sizes respectively, rather than direct colonization or infection analysis denominators.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Age, diagnoses, severity, baseline colonization and infection, sampling sites, treatment histories and arm-specific outcome denominators are needed. Findings are not extended to other populations or infection types.
Required materials and conditions: Disease eligibility, baseline colonization, infection and vulnerable groups
Materials to obtain first: Age, diagnoses, severity, baseline colonization and infection, sampling sites, treatment histories and arm-specific outcome denominators are needed. Findings are not extended to other populations or infection types.
Further research: Material needed: Age, diagnoses, severity, baseline colonization and infection, sampling sites, treatment histories and arm-specific outcome denominators are needed. Findings are not extended to other populations or infection types. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Disease eligibility, baseline colonization, infection and vulnerable groups must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Disease eligibility, baseline colonization, infection and vulnerable groups with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N12 · Is the review's overall size the colonization-outcome denominator?

Current findings: Bakaa's 10 randomized trials and 307 participants are preserved. They do not mean identical included trials and denominators for colonization, severity, patient reports and harms. The review is not counted as a new trial or additional participants.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Outcome-specific inclusion, exclusion, original trials, denominators, overlap, controls, concurrent care and synthesis methods are needed. Unique trial and participant totals remain unverified.
Required materials and conditions: Review size versus outcome-specific original trials and denominators
Materials to obtain first: Outcome-specific inclusion, exclusion, original trials, denominators, overlap, controls, concurrent care and synthesis methods are needed. Unique trial and participant totals remain unverified.
Further research: Material needed: Outcome-specific inclusion, exclusion, original trials, denominators, overlap, controls, concurrent care and synthesis methods are needed. Unique trial and participant totals remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Review size versus outcome-specific original trials and denominators must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Review size versus outcome-specific original trials and denominators with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N13 · Are EASI figures being used as infection effects?

Current findings: EASI-50 of 22% versus 32% and a ratio of means of 0.78 (95% CrI 0.59 to 0.99) concern severity. They are not identical colonization RRs or infection effects, and the CrI is not relabeled as another outcome's CI.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Materials linking outcomes, denominators, original interval types, prespecified analyses and controls are needed. Arm order is not inferred and absolute differences are not calculated.
Required materials and conditions: Distinction between severity response, ratio of means, colonization and infection
Materials to obtain first: Materials linking outcomes, denominators, original interval types, prespecified analyses and controls are needed. Arm order is not inferred and absolute differences are not calculated.
Further research: Material needed: Materials linking outcomes, denominators, original interval types, prespecified analyses and controls are needed. Arm order is not inferred and absolute differences are not calculated. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Distinction between severity response, ratio of means, colonization and infection must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Distinction between severity response, ratio of means, colonization and infection with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R03

N14 · Are patient reports distinguished from eradication and infection prevention?

Current findings: The account says itch, sleep, quality-of-life and infection findings are difficult to judge. An objective severity signal does not establish patient-perceived benefit, eradication or infection prevention.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Original findings, denominators, measurement windows, CIs and importance criteria are needed separately for patient reports, colonization and infection.
Required materials and conditions: Directness of itch, sleep, quality-of-life and microbial findings
Materials to obtain first: Original findings, denominators, measurement windows, CIs and importance criteria are needed separately for patient reports, colonization and infection.
Further research: Material needed: Original findings, denominators, measurement windows, CIs and importance criteria are needed separately for patient reports, colonization and infection. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Directness of itch, sleep, quality-of-life and microbial findings must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Directness of itch, sleep, quality-of-life and microbial findings with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N15 · How far is Wong's citation-only report linked?

Current findings: Wong's citation is a bibliographic summary distinguishing an Asian trial with concurrent care. It lacks a separate evidence row, colonization or infection values and CIs. The parent's 8-week narrative is not established as an exact Wong finding.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Original populations, interventions, concurrent care, durations, outcomes, denominators, effects, CIs, prespecified plans and report relationships are needed.
Required materials and conditions: Distinction between concurrent-care bibliography and direct findings
Materials to obtain first: Original populations, interventions, concurrent care, durations, outcomes, denominators, effects, CIs, prespecified plans and report relationships are needed.
Further research: Material needed: Original populations, interventions, concurrent care, durations, outcomes, denominators, effects, CIs, prespecified plans and report relationships are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Distinction between concurrent-care bibliography and direct findings must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Distinction between concurrent-care bibliography and direct findings with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R02

N16 · Are gaps in unpublished material and prespecified analyses retained?

Current findings: Bakaa's title mentioning unpublished data, Bayesian interpretation and GRADE is preserved. The parent retains gaps in unpublished originals, exact net effects and prespecified primary outcomes; the title does not establish new acquisition or official certification.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Unpublished-report identities, complete originals, registration, protocols, SAPs, prespecified outcomes, changes, denominators and original-trial attribution are needed.
Required materials and conditions: Distinction between a review title and original-data acquisition or prespecification
Materials to obtain first: Unpublished-report identities, complete originals, registration, protocols, SAPs, prespecified outcomes, changes, denominators and original-trial attribution are needed.
Further research: Material needed: Unpublished-report identities, complete originals, registration, protocols, SAPs, prespecified outcomes, changes, denominators and original-trial attribution are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Distinction between a review title and original-data acquisition or prespecification must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Distinction between a review title and original-data acquisition or prespecification with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N17 · Is independent replication verified for colonization and infection?

Current findings: Null water-controlled findings and a small synthesized severity signal are both preserved. They do not newly certify independent replication for colonization or infection; parent R0 and I2 and shared reports are distinguished.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Links between original trials, institutions, recruitment, participants, registration, formulations, controls and outcomes, and findings for the same direct question are needed.
Required materials and conditions: The same question, formulation and comparator, and report or cohort relationships
Materials to obtain first: Links between original trials, institutions, recruitment, participants, registration, formulations, controls and outcomes, and findings for the same direct question are needed.
Further research: Material needed: Links between original trials, institutions, recruitment, participants, registration, formulations, controls and outcomes, and findings for the same direct question are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for The same question, formulation and comparator, and report or cohort relationships must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links The same question, formulation and comparator, and report or cohort relationships with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N18 · Are differences in funding, products, authors and company involvement preserved?

Current findings: Hon's unverified specific funding and COI and the parent's public-funded water-control strength statement are both preserved. Bakaa's academic or public support and no specific manufacturer support reported do not resolve that difference.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Report-specific financial and product support, author affiliations, design, analysis and publication roles, and attribution of the parent funding statement are needed.
Required materials and conditions: Original support and design, analysis and publication roles
Materials to obtain first: Report-specific financial and product support, author affiliations, design, analysis and publication roles, and attribution of the parent funding statement are needed.
Further research: Material needed: Report-specific financial and product support, author affiliations, design, analysis and publication roles, and attribution of the parent funding statement are needed. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Original support and design, analysis and publication roles must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Original support and design, analysis and publication roles with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N19 · Are biases in colonization testing and infection collection known?

Current findings: Hon is preserved as a double-blind crossover trial. Its design label does not verify detailed colonization methods, sites, assessors, missingness or infection collection.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Original culture, sampling, repeated measurements, assessors, missingness, infection diagnoses, selected outcomes and timing are needed. No new official risk-of-bias assessment is performed.
Required materials and conditions: Culture, assessor masking, missingness and selective reporting
Materials to obtain first: Original culture, sampling, repeated measurements, assessors, missingness, infection diagnoses, selected outcomes and timing are needed. No new official risk-of-bias assessment is performed.
Further research: Material needed: Original culture, sampling, repeated measurements, assessors, missingness, infection diagnoses, selected outcomes and timing are needed. No new official risk-of-bias assessment is performed. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Culture, assessor masking, missingness and selective reporting must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Culture, assessor masking, missingness and selective reporting with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N20 · Are recolonization and long-term infection prevention verified?

Current findings: The key crossover's 4 weeks per period and the parent's separate 8-week context are retained. Details of post-treatment recolonization, long-term infection, antibiotic needs and vulnerable groups are absent from the stored summary.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Post-treatment follow-up, continuing care, colonization, infection, harms, exposure, denominators, effects and CIs are needed. Short-term severity findings are not extended to long-term prevention.
Required materials and conditions: Post-treatment persistence, infection, antibiotic needs and follow-up
Materials to obtain first: Post-treatment follow-up, continuing care, colonization, infection, harms, exposure, denominators, effects and CIs are needed. Short-term severity findings are not extended to long-term prevention.
Further research: Material needed: Post-treatment follow-up, continuing care, colonization, infection, harms, exposure, denominators, effects and CIs are needed. Short-term severity findings are not extended to long-term prevention. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Post-treatment persistence, infection, antibiotic needs and follow-up must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Post-treatment persistence, infection, antibiotic needs and follow-up with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N21 · Are actual denominators for skin, eye and airway harms known?

Current findings: The parent's warnings about chemical burns and eye or airway irritation from high concentrations or undiluted products are preserved. Trial-specific harm events, affected participants, exposure, denominators and collection methods are absent from the stored summary.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Original products, exposure, active collection, severity, timing, denominators, withdrawals and materials on children or vulnerable airways are needed. Missing numbers are not converted into safety.
Required materials and conditions: Harm collection, exposure, withdrawal and vulnerable groups
Materials to obtain first: Original products, exposure, active collection, severity, timing, denominators, withdrawals and materials on children or vulnerable airways are needed. Missing numbers are not converted into safety.
Further research: Material needed: Original products, exposure, active collection, severity, timing, denominators, withdrawals and materials on children or vulnerable airways are needed. Missing numbers are not converted into safety. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Harm collection, exposure, withdrawal and vulnerable groups must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Harm collection, exposure, withdrawal and vulnerable groups with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N22 · Is this evidence table a dilution, bathing or medication-change guide?

Current findings: This table preserves the existing intervention, comparison and warnings. It does not create new dilution or bathing steps, frequencies, concentrations or changes to topical medication or antibiotics.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Treatment and procedural decisions are a separate scope. Medication-adjustment recommendations outside the account are not created without original materials and the required review.
Required materials and conditions: Boundary between evidence preservation and procedural or treatment instructions
Materials to obtain first: Treatment and procedural decisions are a separate scope. Medication-adjustment recommendations outside the account are not created without original materials and the required review.
Further research: Material needed: Treatment and procedural decisions are a separate scope. Medication-adjustment recommendations outside the account are not created without original materials and the required review. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Boundary between evidence preservation and procedural or treatment instructions must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Boundary between evidence preservation and procedural or treatment instructions with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N23 · Are the original subclaim grade and parent score or axes distinguished?

Current findings: The selected subclaim grade is D, without an individual score, status or axes. Parent C50, Caution and judgment axes remain separate contexts and do not fill absent subclaim values.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Materials for reviewing parent and subclaim boundaries are needed. No new grades, scores, clinical statuses or independent certification are created.
Required materials and conditions: Subclaim D and absent individual score, status and axes
Materials to obtain first: Materials for reviewing parent and subclaim boundaries are needed. No new grades, scores, clinical statuses or independent certification are created.
Further research: Material needed: Materials for reviewing parent and subclaim boundaries are needed. No new grades, scores, clinical statuses or independent certification are created. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Subclaim D and absent individual score, status and axes must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Subclaim D and absent individual score, status and axes with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N24 · Are stored summaries distinguished from new external reading?

Current findings: The complete stored parent summary is used for production. Historical verification, separation and original-comparison wording remains historical and does not represent new reading of external abstracts, full texts, registration or plans.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Acquisition, actual reading and content review must be recorded separately. An identifier or link alone does not establish completed reading or review.
Required materials and conditions: Existing complete summary versus external abstracts, full texts, registration and plans
Materials to obtain first: Acquisition, actual reading and content review must be recorded separately. An identifier or link alone does not establish completed reading or review.
Further research: Material needed: Acquisition, actual reading and content review must be recorded separately. An identifier or link alone does not establish completed reading or review. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Existing complete summary versus external abstracts, full texts, registration and plans must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Existing complete summary versus external abstracts, full texts, registration and plans with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N25 · Are bilingual representative descriptions applied to every trial?

Current findings: The complete parent Korean and English accounts are preserved. Representative populations, doses and outcomes are not automatically applied as identical denominators, exposure or effects across every report, arm and outcome.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Report-specific populations, formulations, controls, outcomes, timing and denominators need linking. No new external English comparison or correction review was performed.
Required materials and conditions: Original scope of language, formulation, population, control and outcome
Materials to obtain first: Report-specific populations, formulations, controls, outcomes, timing and denominators need linking. No new external English comparison or correction review was performed.
Further research: Material needed: Report-specific populations, formulations, controls, outcomes, timing and denominators need linking. No new external English comparison or correction review was performed. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Original scope of language, formulation, population, control and outcome must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Original scope of language, formulation, population, control and outcome with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N26 · Are report and material counts used as unique trials or quality scores?

Current findings: Report links, stored summaries and external material entries form the table's structure. They are not acquired external papers, unique trials, participants, independent replications or quality scores; reports shared across questions are not added.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Original trial, report, recruitment and participant links and actual material-reading records are needed. Unique trial and participant totals remain unverified.
Required materials and conditions: Distinction between preservation structure, clinical units and actual reading
Materials to obtain first: Original trial, report, recruitment and participant links and actual material-reading records are needed. Unique trial and participant totals remain unverified.
Further research: Material needed: Original trial, report, recruitment and participant links and actual material-reading records are needed. Unique trial and participant totals remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Distinction between preservation structure, clinical units and actual reading must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Distinction between preservation structure, clinical units and actual reading with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N27 · Are the original evidence date, corrections and production records distinguished?

Current findings: The original evidence date of 2026-09-07 and empty correction and deliberation records are retained. Production time is not converted into a new evidence-verification date, and nonexistent corrections are not created.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Additional material, revised conditions, applied observations and judgment changes are separate events. Complete originals and reasons for changes must be preserved and linked to the required content review.
Required materials and conditions: Original evidence date and empty correction or deliberation records
Materials to obtain first: Additional material, revised conditions, applied observations and judgment changes are separate events. Complete originals and reasons for changes must be preserved and linked to the required content review.
Further research: Material needed: Additional material, revised conditions, applied observations and judgment changes are separate events. Complete originals and reasons for changes must be preserved and linked to the required content review. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Original evidence date and empty correction or deliberation records must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Original evidence date and empty correction or deliberation records with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

Related sources R01 R02 R03

N28 · How are new materials and question changes linked?

Current findings: Current originals, conditions and observations are preserved. This work is not a new clinical search, calculation or change to the original judgment; future materials need linking to the relevant comparisons, outcomes, denominators and report boundaries.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread
Why unverified: This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.
Reason for missing information: Complete originals, events, versions, reasons for changes and the required review must be recorded. New dilution, procedural, medication-change or treatment instructions are not written.
Required materials and conditions: Distinction between condition revisions, material updates and judgment changes
Materials to obtain first: Complete originals, events, versions, reasons for changes and the required review must be recorded. New dilution, procedural, medication-change or treatment instructions are not written.
Further research: Material needed: Complete originals, events, versions, reasons for changes and the required review must be recorded. New dilution, procedural, medication-change or treatment instructions are not written. This records needed materials; no new research was executed.
Remaining uncertainty: Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.
Conditions for verification: Original material for Distinction between condition revisions, material updates and judgment changes must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.
Why this condition is needed: This condition links Distinction between condition revisions, material updates and judgment changes with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.
Application exceptions: Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.
Referenced methods: Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.

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