{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Dilute sodium-hypochlorite baths added to standard care × Reduced S. aureus colonization or infection",
  "language": "en",
  "translation_date": "2026-10-20",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "What is the original conclusion for the selected colonization and infection question?",
      "needed": "Original subclaim and distinction between colonization and infection",
      "role": "Required",
      "role_reason": "This condition links Original subclaim and distinction between colonization and infection with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Original subclaim and distinction between colonization and infection must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original trials, outcomes, denominators, effects and intervals are needed separately for colonization and infection. Linking the existing question does not certify new independence. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Are colonization and actual infection the same outcome?",
      "needed": "Distinction between microbial colonization, infection events and clinical severity",
      "role": "Required",
      "role_reason": "This condition links Distinction between microbial colonization, infection events and clinical severity with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Distinction between microbial colonization, infection events and clinical severity must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Definitions of culture, detection and colonization and separate clinical infection diagnoses, events, timing, collection methods and denominators are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "What colonization RR and interval are preserved?",
      "needed": "Original material for the colonization relative effect and precision",
      "role": "Required",
      "role_reason": "This condition links Original material for the colonization relative effect and precision with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Original material for the colonization relative effect and precision must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original reporting is needed for colonization definitions, included trials, denominators, control risks, timing, synthesis methods and interval type. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Does a null colonization finding establish eradication or an exact zero effect?",
      "needed": "Distinction between nonsignificance, eradication and equivalence",
      "role": "Required",
      "role_reason": "This condition links Distinction between nonsignificance, eradication and equivalence with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Distinction between nonsignificance, eradication and equivalence must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Direct colonization findings, intervals, clinical importance boundaries, denominators, tests and measurement methods are needed. No new eradication or equivalence judgment or interval calculation is made. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Are direct clinical infection values and denominators known?",
      "needed": "Infection diagnoses, events, affected participants and observation windows",
      "role": "Required",
      "role_reason": "This condition links Infection diagnoses, events, affected participants and observation windows with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Infection diagnoses, events, affected participants and observation windows must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Infection definitions, severity, recurrent events, medication and hospitalization needs, observation windows, denominators, effects and CIs are needed. Event or patient counts are not invented or added. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Are antibiotic and standard-care effects distinguished?",
      "needed": "Attribution of concurrent care and the added ingredient effect",
      "role": "Required",
      "role_reason": "This condition links Attribution of concurrent care and the added ingredient effect with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Attribution of concurrent care and the added ingredient effect must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Trial-specific antibiotics, emollients, topical medication, changes, infection-treatment criteria and outcome denominators are needed. Multicomponent treatment findings are not attributed to the ingredient alone. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Is shared improvement from water bathing an added ingredient effect?",
      "needed": "Distinction between water controls, usual care and shared care",
      "role": "Required",
      "role_reason": "This condition links Distinction between water controls, usual care and shared care with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Distinction between water controls, usual care and shared care must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Arm-specific bathing, treatment, contact, adherence, control conditions and direct between-arm colonization and infection findings are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Which outcome does Hon's water-controlled finding describe?",
      "needed": "Distinction between severity and colonization or infection findings",
      "role": "Required",
      "role_reason": "This condition links Distinction between severity and colonization or infection findings with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Distinction between severity and colonization or infection findings must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Separate measurements, between-arm findings, denominators, hierarchies and CIs are needed for colonization, infection and SCORAD. Affected-area values and P are not transferred to microbial outcomes. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What analysis units do Hon's completion and nonadherence counts represent?",
      "needed": "Crossover denominators, adherence, ITT and missingness",
      "role": "Required",
      "role_reason": "This condition links Crossover denominators, adherence, ITT and missingness with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Crossover denominators, adherence, ITT and missingness must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original material is needed for period-specific allocation, sequence, carryover, within-participant correlation, outcome denominators, nonadherence definitions, ITT and handling of missingness. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are differences in products, concentrations, exposure and duration known?",
      "needed": "Trial-specific formulations, final concentrations and actual exposure",
      "role": "Required",
      "role_reason": "This condition links Trial-specific formulations, final concentrations and actual exposure with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Trial-specific formulations, final concentrations and actual exposure must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Trial-specific products, final concentrations, concurrent care, actual exposure, adherence, timing and findings are needed. No new dilution or treatment instructions are created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Are the population and colonization-sampling denominators known?",
      "needed": "Disease eligibility, baseline colonization, infection and vulnerable groups",
      "role": "Required",
      "role_reason": "This condition links Disease eligibility, baseline colonization, infection and vulnerable groups with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Disease eligibility, baseline colonization, infection and vulnerable groups must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Age, diagnoses, severity, baseline colonization and infection, sampling sites, treatment histories and arm-specific outcome denominators are needed. Findings are not extended to other populations or infection types. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Is the review's overall size the colonization-outcome denominator?",
      "needed": "Review size versus outcome-specific original trials and denominators",
      "role": "Required",
      "role_reason": "This condition links Review size versus outcome-specific original trials and denominators with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Review size versus outcome-specific original trials and denominators must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Outcome-specific inclusion, exclusion, original trials, denominators, overlap, controls, concurrent care and synthesis methods are needed. Unique trial and participant totals remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Are EASI figures being used as infection effects?",
      "needed": "Distinction between severity response, ratio of means, colonization and infection",
      "role": "Required",
      "role_reason": "This condition links Distinction between severity response, ratio of means, colonization and infection with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Distinction between severity response, ratio of means, colonization and infection must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Materials linking outcomes, denominators, original interval types, prespecified analyses and controls are needed. Arm order is not inferred and absolute differences are not calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Are patient reports distinguished from eradication and infection prevention?",
      "needed": "Directness of itch, sleep, quality-of-life and microbial findings",
      "role": "Required",
      "role_reason": "This condition links Directness of itch, sleep, quality-of-life and microbial findings with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Directness of itch, sleep, quality-of-life and microbial findings must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original findings, denominators, measurement windows, CIs and importance criteria are needed separately for patient reports, colonization and infection. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "How far is Wong's citation-only report linked?",
      "needed": "Distinction between concurrent-care bibliography and direct findings",
      "role": "Required",
      "role_reason": "This condition links Distinction between concurrent-care bibliography and direct findings with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Distinction between concurrent-care bibliography and direct findings must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original populations, interventions, concurrent care, durations, outcomes, denominators, effects, CIs, prespecified plans and report relationships are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Are gaps in unpublished material and prespecified analyses retained?",
      "needed": "Distinction between a review title and original-data acquisition or prespecification",
      "role": "Required",
      "role_reason": "This condition links Distinction between a review title and original-data acquisition or prespecification with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Distinction between a review title and original-data acquisition or prespecification must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Unpublished-report identities, complete originals, registration, protocols, SAPs, prespecified outcomes, changes, denominators and original-trial attribution are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Is independent replication verified for colonization and infection?",
      "needed": "The same question, formulation and comparator, and report or cohort relationships",
      "role": "Required",
      "role_reason": "This condition links The same question, formulation and comparator, and report or cohort relationships with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for The same question, formulation and comparator, and report or cohort relationships must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Links between original trials, institutions, recruitment, participants, registration, formulations, controls and outcomes, and findings for the same direct question are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Are differences in funding, products, authors and company involvement preserved?",
      "needed": "Original support and design, analysis and publication roles",
      "role": "Required",
      "role_reason": "This condition links Original support and design, analysis and publication roles with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Original support and design, analysis and publication roles must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Report-specific financial and product support, author affiliations, design, analysis and publication roles, and attribution of the parent funding statement are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Are biases in colonization testing and infection collection known?",
      "needed": "Culture, assessor masking, missingness and selective reporting",
      "role": "Required",
      "role_reason": "This condition links Culture, assessor masking, missingness and selective reporting with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Culture, assessor masking, missingness and selective reporting must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original culture, sampling, repeated measurements, assessors, missingness, infection diagnoses, selected outcomes and timing are needed. No new official risk-of-bias assessment is performed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Are recolonization and long-term infection prevention verified?",
      "needed": "Post-treatment persistence, infection, antibiotic needs and follow-up",
      "role": "Required",
      "role_reason": "This condition links Post-treatment persistence, infection, antibiotic needs and follow-up with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Post-treatment persistence, infection, antibiotic needs and follow-up must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Post-treatment follow-up, continuing care, colonization, infection, harms, exposure, denominators, effects and CIs are needed. Short-term severity findings are not extended to long-term prevention. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Are actual denominators for skin, eye and airway harms known?",
      "needed": "Harm collection, exposure, withdrawal and vulnerable groups",
      "role": "Supplementary",
      "role_reason": "This condition links Harm collection, exposure, withdrawal and vulnerable groups with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Harm collection, exposure, withdrawal and vulnerable groups must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original products, exposure, active collection, severity, timing, denominators, withdrawals and materials on children or vulnerable airways are needed. Missing numbers are not converted into safety. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Is this evidence table a dilution, bathing or medication-change guide?",
      "needed": "Boundary between evidence preservation and procedural or treatment instructions",
      "role": "Supplementary",
      "role_reason": "This condition links Boundary between evidence preservation and procedural or treatment instructions with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Boundary between evidence preservation and procedural or treatment instructions must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Treatment and procedural decisions are a separate scope. Medication-adjustment recommendations outside the account are not created without original materials and the required review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Are the original subclaim grade and parent score or axes distinguished?",
      "needed": "Subclaim D and absent individual score, status and axes",
      "role": "Required",
      "role_reason": "This condition links Subclaim D and absent individual score, status and axes with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Subclaim D and absent individual score, status and axes must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Materials for reviewing parent and subclaim boundaries are needed. No new grades, scores, clinical statuses or independent certification are created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Are stored summaries distinguished from new external reading?",
      "needed": "Existing complete summary versus external abstracts, full texts, registration and plans",
      "role": "Required",
      "role_reason": "This condition links Existing complete summary versus external abstracts, full texts, registration and plans with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Existing complete summary versus external abstracts, full texts, registration and plans must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Acquisition, actual reading and content review must be recorded separately. An identifier or link alone does not establish completed reading or review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Are bilingual representative descriptions applied to every trial?",
      "needed": "Original scope of language, formulation, population, control and outcome",
      "role": "Required",
      "role_reason": "This condition links Original scope of language, formulation, population, control and outcome with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Original scope of language, formulation, population, control and outcome must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Report-specific populations, formulations, controls, outcomes, timing and denominators need linking. No new external English comparison or correction review was performed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are report and material counts used as unique trials or quality scores?",
      "needed": "Distinction between preservation structure, clinical units and actual reading",
      "role": "Required",
      "role_reason": "This condition links Distinction between preservation structure, clinical units and actual reading with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Distinction between preservation structure, clinical units and actual reading must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original trial, report, recruitment and participant links and actual material-reading records are needed. Unique trial and participant totals remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Are the original evidence date, corrections and production records distinguished?",
      "needed": "Original evidence date and empty correction or deliberation records",
      "role": "Required",
      "role_reason": "This condition links Original evidence date and empty correction or deliberation records with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Original evidence date and empty correction or deliberation records must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Additional material, revised conditions, applied observations and judgment changes are separate events. Complete originals and reasons for changes must be preserved and linked to the required content review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "How are new materials and question changes linked?",
      "needed": "Distinction between condition revisions, material updates and judgment changes",
      "role": "Required",
      "role_reason": "This condition links Distinction between condition revisions, material updates and judgment changes with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.",
      "criterion": "Original material for Distinction between condition revisions, material updates and judgment changes must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Complete originals, events, versions, reasons for changes and the required review must be recorded. New dilution, procedural, medication-change or treatment instructions are not written. This records needed materials; no new research was executed."
    }
  ]
}