{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3008-s2", "verdict_number": "3008", "title": "Dilute sodium-hypochlorite baths added to standard care × Reduced S. aureus colonization or infection", "view_version": "1.0", "view_created_date": "2026-10-20", "criteria_version": "1.0", "criteria_date": "2026-10-06", "review_date": null, "legacy_evidence_date": "2026-09-07", "review_scope": { "materials_read": "Existing review summaries and stored records of methodological application", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.", "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature." }, "claim_context": { "population": "The stored moderate-to-severe atopic-dermatitis scope is retained. Eligibility, baseline status, sampling sites, responses and analysis denominators are unverified for each colonization or infection outcome. Hon 40 completed and 14 nonadherent and the review 10 trials and 307 participants retain their respective contexts; they are not new independent totals or direct colonization or infection denominators.", "intervention": "The intervention is dilute sodium-hypochlorite bathing added to standard care. Exact trial-specific products, final concentrations, formulations, colonization sampling and concurrent care are unverified. No new dilution, procedural or medication-change instructions are created.", "dose": "The parent Hon schedule of 2 times per week and 4 weeks per period is retained only as study context. Actual exposure, product specifications, adherence and quantitative doses are unverified for each colonization or infection outcome. Study records are not converted into personal-use instructions.", "comparator": "Direct water-controlled and usual-care comparisons are distinguished; shared improvement under standard care is not converted into an added bleach-ingredient effect. Antibiotic changes in some trials remain separate contexts, and outcome-specific controls, concurrent care and adherence details are unverified.", "endpoint": "The selection is reduced S. aureus colonization or infection, retaining original subclaim D, a null colonization RR and unestablished clinical infection benefit. The colonization RR of 0.89 (0.73 to 1.09) is preserved without converting it into an infection effect, exact zero effect or equivalence. Direct infection values, CIs, denominators and observation windows are unverified.", "duration": "The key crossover periods of 4 weeks and the parent separate 8-week context are preserved. Exact measurement times, observation windows, post-treatment recolonization and long-term prevention details are unverified separately for colonization and infection.", "excluded_extensions": [ "Distinguish colonization detection, positivity, clinical infection events and severity findings.", "Do not convert a null colonization RR into established eradication, exact zero effects or equivalence.", "Do not extend clinician-rated severity or patient-report signals to infection prevention.", "Do not use parent trial or review sizes and shared reports as new unique trial or participant totals.", "Do not create new concentrations, dilution methods, bathing steps, medication changes or treatment instructions." ] }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "What is the original conclusion for the selected colonization and infection question?", "needed": "Original subclaim and distinction between colonization and infection", "role": "Required", "role_reason": "This condition links Original subclaim and distinction between colonization and infection with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Original subclaim and distinction between colonization and infection must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Original trials, outcomes, denominators, effects and intervals are needed separately for colonization and infection. Linking the existing question does not certify new independence. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The selection is reduced S. aureus colonization or infection, with original subclaim D. Its explanation of a null colonization RR and unestablished clinical infection benefit is retained, separately from clinician-rated severity and patient-report questions.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Original trials, outcomes, denominators, effects and intervals are needed separately for colonization and infection. Linking the existing question does not certify new independence.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original trials, outcomes, denominators, effects and intervals are needed separately for colonization and infection. Linking the existing question does not certify new independence." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "Are colonization and actual infection the same outcome?", "needed": "Distinction between microbial colonization, infection events and clinical severity", "role": "Required", "role_reason": "This condition links Distinction between microbial colonization, infection events and clinical severity with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Distinction between microbial colonization, infection events and clinical severity must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Definitions of culture, detection and colonization and separate clinical infection diagnoses, events, timing, collection methods and denominators are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The stored account distinguishes the S. aureus colonization RR from uncertain infection findings. Detection or colonization is not converted into reduced clinical infection occurrence or treatment needs.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Definitions of culture, detection and colonization and separate clinical infection diagnoses, events, timing, collection methods and denominators are needed.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Definitions of culture, detection and colonization and separate clinical infection diagnoses, events, timing, collection methods and denominators are needed." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "What colonization RR and interval are preserved?", "needed": "Original material for the colonization relative effect and precision", "role": "Required", "role_reason": "This condition links Original material for the colonization relative effect and precision with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Original material for the colonization relative effect and precision must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Original reporting is needed for colonization definitions, included trials, denominators, control risks, timing, synthesis methods and interval type. This records needed materials; no new research was executed.", "current_reports": [ "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The colonization RR of 0.89 (0.73 to 1.09) from Bakaa and the parent explanation is preserved. The account that the interval includes 1 and the null colonization finding are retained without calculating an absolute reduction.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Original reporting is needed for colonization definitions, included trials, denominators, control risks, timing, synthesis methods and interval type.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original reporting is needed for colonization definitions, included trials, denominators, control risks, timing, synthesis methods and interval type." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "Does a null colonization finding establish eradication or an exact zero effect?", "needed": "Distinction between nonsignificance, eradication and equivalence", "role": "Required", "role_reason": "This condition links Distinction between nonsignificance, eradication and equivalence with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Distinction between nonsignificance, eradication and equivalence must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Direct colonization findings, intervals, clinical importance boundaries, denominators, tests and measurement methods are needed. No new eradication or equivalence judgment or interval calculation is made. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The original null colonization conclusion is retained. It is not converted into established eradication or precise equivalence demonstrating that every effect is exactly 0.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Direct colonization findings, intervals, clinical importance boundaries, denominators, tests and measurement methods are needed. No new eradication or equivalence judgment or interval calculation is made.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct colonization findings, intervals, clinical importance boundaries, denominators, tests and measurement methods are needed. No new eradication or equivalence judgment or interval calculation is made." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "Are direct clinical infection values and denominators known?", "needed": "Infection diagnoses, events, affected participants and observation windows", "role": "Required", "role_reason": "This condition links Infection diagnoses, events, affected participants and observation windows with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Infection diagnoses, events, affected participants and observation windows must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Infection definitions, severity, recurrent events, medication and hospitalization needs, observation windows, denominators, effects and CIs are needed. Event or patient counts are not invented or added. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The existing account states that reduced clinical infection is unestablished. Original infection events, affected participants, arm-specific denominators, direct effects, CIs and durations are absent from the stored summary. The colonization RR is not copied as an infection RR.", "condition_status": "Unverified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Infection definitions, severity, recurrent events, medication and hospitalization needs, observation windows, denominators, effects and CIs are needed. Event or patient counts are not invented or added.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Infection definitions, severity, recurrent events, medication and hospitalization needs, observation windows, denominators, effects and CIs are needed. Event or patient counts are not invented or added." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "Are antibiotic and standard-care effects distinguished?", "needed": "Attribution of concurrent care and the added ingredient effect", "role": "Required", "role_reason": "This condition links Attribution of concurrent care and the added ingredient effect with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Attribution of concurrent care and the added ingredient effect must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Trial-specific antibiotics, emollients, topical medication, changes, infection-treatment criteria and outcome denominators are needed. Multicomponent treatment findings are not attributed to the ingredient alone. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The parent account says emollients and topical treatment continued and simultaneous antibiotic changes in some trials were separated from an effect of bleach alone. Wong's bibliographic summary also concerns concurrent care.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Trial-specific antibiotics, emollients, topical medication, changes, infection-treatment criteria and outcome denominators are needed. Multicomponent treatment findings are not attributed to the ingredient alone.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Trial-specific antibiotics, emollients, topical medication, changes, infection-treatment criteria and outcome denominators are needed. Multicomponent treatment findings are not attributed to the ingredient alone." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "Is shared improvement from water bathing an added ingredient effect?", "needed": "Distinction between water controls, usual care and shared care", "role": "Required", "role_reason": "This condition links Distinction between water controls, usual care and shared care with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Distinction between water controls, usual care and shared care must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Arm-specific bathing, treatment, contact, adherence, control conditions and direct between-arm colonization and infection findings are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The original explanation that shared improvement with bathing, emollients and topical care is not an added ingredient effect is retained. Direct water-controlled and usual-care comparisons are not combined as the same effect.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Arm-specific bathing, treatment, contact, adherence, control conditions and direct between-arm colonization and infection findings are needed.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm-specific bathing, treatment, contact, adherence, control conditions and direct between-arm colonization and infection findings are needed." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "Which outcome does Hon's water-controlled finding describe?", "needed": "Distinction between severity and colonization or infection findings", "role": "Required", "role_reason": "This condition links Distinction between severity and colonization or infection findings with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Distinction between severity and colonization or infection findings must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Separate measurements, between-arm findings, denominators, hierarchies and CIs are needed for colonization, infection and SCORAD. Affected-area values and P are not transferred to microbial outcomes. This records needed materials; no new research was executed.", "current_reports": [ "R01" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "Hon's no added bleach benefit by ITT and affected-area SCORAD change of water -5.7±15.4 versus bleach 0.6±12.4, P=.03, are preserved. Affected-area values are not effects on colonization levels or infection events.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Separate measurements, between-arm findings, denominators, hierarchies and CIs are needed for colonization, infection and SCORAD. Affected-area values and P are not transferred to microbial outcomes.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Separate measurements, between-arm findings, denominators, hierarchies and CIs are needed for colonization, infection and SCORAD. Affected-area values and P are not transferred to microbial outcomes." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "What analysis units do Hon's completion and nonadherence counts represent?", "needed": "Crossover denominators, adherence, ITT and missingness", "role": "Required", "role_reason": "This condition links Crossover denominators, adherence, ITT and missingness with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Crossover denominators, adherence, ITT and missingness must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Original material is needed for period-specific allocation, sequence, carryover, within-participant correlation, outcome denominators, nonadherence definitions, ITT and handling of missingness. This records needed materials; no new research was executed.", "current_reports": [ "R01" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "Hon's 40 completed, 14 nonadherent and the citation's 14/40 are preserved. The parent's 40-person crossover, 4 weeks per period and null ITT findings remain original contexts; nonadherence is not calculated as simple dropout.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Original material is needed for period-specific allocation, sequence, carryover, within-participant correlation, outcome denominators, nonadherence definitions, ITT and handling of missingness.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original material is needed for period-specific allocation, sequence, carryover, within-participant correlation, outcome denominators, nonadherence definitions, ITT and handling of missingness." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "Are differences in products, concentrations, exposure and duration known?", "needed": "Trial-specific formulations, final concentrations and actual exposure", "role": "Required", "role_reason": "This condition links Trial-specific formulations, final concentrations and actual exposure with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Trial-specific formulations, final concentrations and actual exposure must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Trial-specific products, final concentrations, concurrent care, actual exposure, adherence, timing and findings are needed. No new dilution or treatment instructions are created. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The existing account distinguishes different concentrations and products, 4 weeks per period in the key crossover and a separate 8-week context. It does not provide an exact common concentration or exposure.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Trial-specific products, final concentrations, concurrent care, actual exposure, adherence, timing and findings are needed. No new dilution or treatment instructions are created.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Trial-specific products, final concentrations, concurrent care, actual exposure, adherence, timing and findings are needed. No new dilution or treatment instructions are created." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Are the population and colonization-sampling denominators known?", "needed": "Disease eligibility, baseline colonization, infection and vulnerable groups", "role": "Required", "role_reason": "This condition links Disease eligibility, baseline colonization, infection and vulnerable groups with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Disease eligibility, baseline colonization, infection and vulnerable groups must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Age, diagnoses, severity, baseline colonization and infection, sampling sites, treatment histories and arm-specific outcome denominators are needed. Findings are not extended to other populations or infection types. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The parent concerns moderate-to-severe atopic dermatitis, and Hon's bibliography specifies childhood onset eczema. The 40 and 307 participants describe trial and review sizes respectively, rather than direct colonization or infection analysis denominators.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Age, diagnoses, severity, baseline colonization and infection, sampling sites, treatment histories and arm-specific outcome denominators are needed. Findings are not extended to other populations or infection types.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Age, diagnoses, severity, baseline colonization and infection, sampling sites, treatment histories and arm-specific outcome denominators are needed. Findings are not extended to other populations or infection types." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "Is the review's overall size the colonization-outcome denominator?", "needed": "Review size versus outcome-specific original trials and denominators", "role": "Required", "role_reason": "This condition links Review size versus outcome-specific original trials and denominators with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Review size versus outcome-specific original trials and denominators must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Outcome-specific inclusion, exclusion, original trials, denominators, overlap, controls, concurrent care and synthesis methods are needed. Unique trial and participant totals remain unverified. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "Bakaa's 10 randomized trials and 307 participants are preserved. They do not mean identical included trials and denominators for colonization, severity, patient reports and harms. The review is not counted as a new trial or additional participants.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Outcome-specific inclusion, exclusion, original trials, denominators, overlap, controls, concurrent care and synthesis methods are needed. Unique trial and participant totals remain unverified.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Outcome-specific inclusion, exclusion, original trials, denominators, overlap, controls, concurrent care and synthesis methods are needed. Unique trial and participant totals remain unverified." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Are EASI figures being used as infection effects?", "needed": "Distinction between severity response, ratio of means, colonization and infection", "role": "Required", "role_reason": "This condition links Distinction between severity response, ratio of means, colonization and infection with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Distinction between severity response, ratio of means, colonization and infection must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Materials linking outcomes, denominators, original interval types, prespecified analyses and controls are needed. Arm order is not inferred and absolute differences are not calculated. This records needed materials; no new research was executed.", "current_reports": [ "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "EASI-50 of 22% versus 32% and a ratio of means of 0.78 (95% CrI 0.59 to 0.99) concern severity. They are not identical colonization RRs or infection effects, and the CrI is not relabeled as another outcome's CI.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Materials linking outcomes, denominators, original interval types, prespecified analyses and controls are needed. Arm order is not inferred and absolute differences are not calculated.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Materials linking outcomes, denominators, original interval types, prespecified analyses and controls are needed. Arm order is not inferred and absolute differences are not calculated." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "Are patient reports distinguished from eradication and infection prevention?", "needed": "Directness of itch, sleep, quality-of-life and microbial findings", "role": "Required", "role_reason": "This condition links Directness of itch, sleep, quality-of-life and microbial findings with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Directness of itch, sleep, quality-of-life and microbial findings must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Original findings, denominators, measurement windows, CIs and importance criteria are needed separately for patient reports, colonization and infection. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The account says itch, sleep, quality-of-life and infection findings are difficult to judge. An objective severity signal does not establish patient-perceived benefit, eradication or infection prevention.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Original findings, denominators, measurement windows, CIs and importance criteria are needed separately for patient reports, colonization and infection.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original findings, denominators, measurement windows, CIs and importance criteria are needed separately for patient reports, colonization and infection." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "How far is Wong's citation-only report linked?", "needed": "Distinction between concurrent-care bibliography and direct findings", "role": "Required", "role_reason": "This condition links Distinction between concurrent-care bibliography and direct findings with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Distinction between concurrent-care bibliography and direct findings must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Original populations, interventions, concurrent care, durations, outcomes, denominators, effects, CIs, prespecified plans and report relationships are needed. This records needed materials; no new research was executed.", "current_reports": [ "R02" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "Wong's citation is a bibliographic summary distinguishing an Asian trial with concurrent care. It lacks a separate evidence row, colonization or infection values and CIs. The parent's 8-week narrative is not established as an exact Wong finding.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Original populations, interventions, concurrent care, durations, outcomes, denominators, effects, CIs, prespecified plans and report relationships are needed.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original populations, interventions, concurrent care, durations, outcomes, denominators, effects, CIs, prespecified plans and report relationships are needed." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Are gaps in unpublished material and prespecified analyses retained?", "needed": "Distinction between a review title and original-data acquisition or prespecification", "role": "Required", "role_reason": "This condition links Distinction between a review title and original-data acquisition or prespecification with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Distinction between a review title and original-data acquisition or prespecification must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Unpublished-report identities, complete originals, registration, protocols, SAPs, prespecified outcomes, changes, denominators and original-trial attribution are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "Bakaa's title mentioning unpublished data, Bayesian interpretation and GRADE is preserved. The parent retains gaps in unpublished originals, exact net effects and prespecified primary outcomes; the title does not establish new acquisition or official certification.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Unpublished-report identities, complete originals, registration, protocols, SAPs, prespecified outcomes, changes, denominators and original-trial attribution are needed.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Unpublished-report identities, complete originals, registration, protocols, SAPs, prespecified outcomes, changes, denominators and original-trial attribution are needed." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Is independent replication verified for colonization and infection?", "needed": "The same question, formulation and comparator, and report or cohort relationships", "role": "Required", "role_reason": "This condition links The same question, formulation and comparator, and report or cohort relationships with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for The same question, formulation and comparator, and report or cohort relationships must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Links between original trials, institutions, recruitment, participants, registration, formulations, controls and outcomes, and findings for the same direct question are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "Null water-controlled findings and a small synthesized severity signal are both preserved. They do not newly certify independent replication for colonization or infection; parent R0 and I2 and shared reports are distinguished.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Links between original trials, institutions, recruitment, participants, registration, formulations, controls and outcomes, and findings for the same direct question are needed.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Links between original trials, institutions, recruitment, participants, registration, formulations, controls and outcomes, and findings for the same direct question are needed." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "Are differences in funding, products, authors and company involvement preserved?", "needed": "Original support and design, analysis and publication roles", "role": "Required", "role_reason": "This condition links Original support and design, analysis and publication roles with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Original support and design, analysis and publication roles must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Report-specific financial and product support, author affiliations, design, analysis and publication roles, and attribution of the parent funding statement are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "Hon's unverified specific funding and COI and the parent's public-funded water-control strength statement are both preserved. Bakaa's academic or public support and no specific manufacturer support reported do not resolve that difference.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Report-specific financial and product support, author affiliations, design, analysis and publication roles, and attribution of the parent funding statement are needed.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Report-specific financial and product support, author affiliations, design, analysis and publication roles, and attribution of the parent funding statement are needed." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Are biases in colonization testing and infection collection known?", "needed": "Culture, assessor masking, missingness and selective reporting", "role": "Required", "role_reason": "This condition links Culture, assessor masking, missingness and selective reporting with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Culture, assessor masking, missingness and selective reporting must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Original culture, sampling, repeated measurements, assessors, missingness, infection diagnoses, selected outcomes and timing are needed. No new official risk-of-bias assessment is performed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "Hon is preserved as a double-blind crossover trial. Its design label does not verify detailed colonization methods, sites, assessors, missingness or infection collection.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Original culture, sampling, repeated measurements, assessors, missingness, infection diagnoses, selected outcomes and timing are needed. No new official risk-of-bias assessment is performed.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original culture, sampling, repeated measurements, assessors, missingness, infection diagnoses, selected outcomes and timing are needed. No new official risk-of-bias assessment is performed." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "Are recolonization and long-term infection prevention verified?", "needed": "Post-treatment persistence, infection, antibiotic needs and follow-up", "role": "Required", "role_reason": "This condition links Post-treatment persistence, infection, antibiotic needs and follow-up with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Post-treatment persistence, infection, antibiotic needs and follow-up must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Post-treatment follow-up, continuing care, colonization, infection, harms, exposure, denominators, effects and CIs are needed. Short-term severity findings are not extended to long-term prevention. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The key crossover's 4 weeks per period and the parent's separate 8-week context are retained. Details of post-treatment recolonization, long-term infection, antibiotic needs and vulnerable groups are absent from the stored summary.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Post-treatment follow-up, continuing care, colonization, infection, harms, exposure, denominators, effects and CIs are needed. Short-term severity findings are not extended to long-term prevention.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Post-treatment follow-up, continuing care, colonization, infection, harms, exposure, denominators, effects and CIs are needed. Short-term severity findings are not extended to long-term prevention." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "Are actual denominators for skin, eye and airway harms known?", "needed": "Harm collection, exposure, withdrawal and vulnerable groups", "role": "Supplementary", "role_reason": "This condition links Harm collection, exposure, withdrawal and vulnerable groups with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Harm collection, exposure, withdrawal and vulnerable groups must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Original products, exposure, active collection, severity, timing, denominators, withdrawals and materials on children or vulnerable airways are needed. Missing numbers are not converted into safety. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The parent's warnings about chemical burns and eye or airway irritation from high concentrations or undiluted products are preserved. Trial-specific harm events, affected participants, exposure, denominators and collection methods are absent from the stored summary.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Original products, exposure, active collection, severity, timing, denominators, withdrawals and materials on children or vulnerable airways are needed. Missing numbers are not converted into safety.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original products, exposure, active collection, severity, timing, denominators, withdrawals and materials on children or vulnerable airways are needed. Missing numbers are not converted into safety." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "Is this evidence table a dilution, bathing or medication-change guide?", "needed": "Boundary between evidence preservation and procedural or treatment instructions", "role": "Supplementary", "role_reason": "This condition links Boundary between evidence preservation and procedural or treatment instructions with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Boundary between evidence preservation and procedural or treatment instructions must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Treatment and procedural decisions are a separate scope. Medication-adjustment recommendations outside the account are not created without original materials and the required review. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "This table preserves the existing intervention, comparison and warnings. It does not create new dilution or bathing steps, frequencies, concentrations or changes to topical medication or antibiotics.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Treatment and procedural decisions are a separate scope. Medication-adjustment recommendations outside the account are not created without original materials and the required review.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Treatment and procedural decisions are a separate scope. Medication-adjustment recommendations outside the account are not created without original materials and the required review." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "Are the original subclaim grade and parent score or axes distinguished?", "needed": "Subclaim D and absent individual score, status and axes", "role": "Required", "role_reason": "This condition links Subclaim D and absent individual score, status and axes with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Subclaim D and absent individual score, status and axes must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Materials for reviewing parent and subclaim boundaries are needed. No new grades, scores, clinical statuses or independent certification are created. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The selected subclaim grade is D, without an individual score, status or axes. Parent C50, Caution and judgment axes remain separate contexts and do not fill absent subclaim values.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Materials for reviewing parent and subclaim boundaries are needed. No new grades, scores, clinical statuses or independent certification are created.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Materials for reviewing parent and subclaim boundaries are needed. No new grades, scores, clinical statuses or independent certification are created." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Are stored summaries distinguished from new external reading?", "needed": "Existing complete summary versus external abstracts, full texts, registration and plans", "role": "Required", "role_reason": "This condition links Existing complete summary versus external abstracts, full texts, registration and plans with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Existing complete summary versus external abstracts, full texts, registration and plans must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Acquisition, actual reading and content review must be recorded separately. An identifier or link alone does not establish completed reading or review. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The complete stored parent summary is used for production. Historical verification, separation and original-comparison wording remains historical and does not represent new reading of external abstracts, full texts, registration or plans.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Acquisition, actual reading and content review must be recorded separately. An identifier or link alone does not establish completed reading or review.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Acquisition, actual reading and content review must be recorded separately. An identifier or link alone does not establish completed reading or review." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "Are bilingual representative descriptions applied to every trial?", "needed": "Original scope of language, formulation, population, control and outcome", "role": "Required", "role_reason": "This condition links Original scope of language, formulation, population, control and outcome with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Original scope of language, formulation, population, control and outcome must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Report-specific populations, formulations, controls, outcomes, timing and denominators need linking. No new external English comparison or correction review was performed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The complete parent Korean and English accounts are preserved. Representative populations, doses and outcomes are not automatically applied as identical denominators, exposure or effects across every report, arm and outcome.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Report-specific populations, formulations, controls, outcomes, timing and denominators need linking. No new external English comparison or correction review was performed.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Report-specific populations, formulations, controls, outcomes, timing and denominators need linking. No new external English comparison or correction review was performed." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "Are report and material counts used as unique trials or quality scores?", "needed": "Distinction between preservation structure, clinical units and actual reading", "role": "Required", "role_reason": "This condition links Distinction between preservation structure, clinical units and actual reading with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Distinction between preservation structure, clinical units and actual reading must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Original trial, report, recruitment and participant links and actual material-reading records are needed. Unique trial and participant totals remain unverified. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "Report links, stored summaries and external material entries form the table's structure. They are not acquired external papers, unique trials, participants, independent replications or quality scores; reports shared across questions are not added.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Original trial, report, recruitment and participant links and actual material-reading records are needed. Unique trial and participant totals remain unverified.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original trial, report, recruitment and participant links and actual material-reading records are needed. Unique trial and participant totals remain unverified." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "Are the original evidence date, corrections and production records distinguished?", "needed": "Original evidence date and empty correction or deliberation records", "role": "Required", "role_reason": "This condition links Original evidence date and empty correction or deliberation records with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Original evidence date and empty correction or deliberation records must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Additional material, revised conditions, applied observations and judgment changes are separate events. Complete originals and reasons for changes must be preserved and linked to the required content review. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "The original evidence date of 2026-09-07 and empty correction and deliberation records are retained. Production time is not converted into a new evidence-verification date, and nonexistent corrections are not created.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Additional material, revised conditions, applied observations and judgment changes are separate events. Complete originals and reasons for changes must be preserved and linked to the required content review.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Additional material, revised conditions, applied observations and judgment changes are separate events. Complete originals and reasons for changes must be preserved and linked to the required content review." }, { "item_id": "N28", "question_type": "Evidence condition", "question": "How are new materials and question changes linked?", "needed": "Distinction between condition revisions, material updates and judgment changes", "role": "Required", "role_reason": "This condition links Distinction between condition revisions, material updates and judgment changes with definitions, populations, exposure, controls, denominators, timing, analyses, support and harms for colonization and clinical infection.", "application_exception": "Retain original subclaim D and absent individual score, status and axes. Distinguish colonization from clinical infection without filling findings or denominators with EASI, SCORAD, patient reports or parent C50. No new independent totals, effects, intervals, grades, dilution or treatment instructions are created.", "criterion": "Original material for Distinction between condition revisions, material updates and judgment changes must be linked to the relevant outcome, between-arm comparison, denominator and observation window, distinguishing stored summaries, unread external materials, colonization, clinical infection and other severity findings.", "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.", "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.", "proposed_research": "Material needed: Complete originals, events, versions, reasons for changes and the required review must be recorded. New dilution, procedural, medication-change or treatment instructions are not written. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03" ], "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread", "observation": "Current originals, conditions and observations are preserved. This work is not a new clinical search, calculation or change to the original judgment; future materials need linking to the relevant comparisons, outcomes, denominators and report boundaries.", "condition_status": "Partly verified", "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.", "missingness": "Complete originals, events, versions, reasons for changes and the required review must be recorded. New dilution, procedural, medication-change or treatment instructions are not written.", "uncertainty": "Retain the original null colonization finding and unestablished clinical infection benefit. Gaps remain in outcome-specific definitions, timing, denominators, analyses, support, harms and external originals. Design or bibliographic labels and other severity signals are not converted into infection prevention, eradication, precise zero effects or safety certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Complete originals, events, versions, reasons for changes and the required review must be recorded. New dilution, procedural, medication-change or treatment instructions are not written." } ], "reports": [ { "report_id": "R01", "title": "Hon KL, Tsang YC, Lee VW, et al. Efficacy of sodium hypochlorite (bleach) baths to reduce Staphylococcus aureus colonization in childhood onset moderate-to-severe eczema: a randomized, placebo-controlled cross-over trial. J Dermatolog Treat. 2016;27:156-162. PMID: 26270469. DOI: 10.3109/09546634.2015.1067669.", "url": "https://pubmed.ncbi.nlm.nih.gov/26270469/", "report_type": "Stored report providing same-water-control and severity context", "existence": "The stored summary contains a bibliography; acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external materials unread", "study_family": "Shared report links across the parent and subclaims; outcome-specific inclusion, unique counts and independence unverified", "independent_replication": "Hon, Wong and Bakaa are preserved reports shared across the parent and existing subclaims. Hon 40 completed and 14 nonadherent and the review 10 trials and 307 participants retain their original contexts; they are not direct colonization or infection denominators or independent totals. Unique trial, participant and independent-replication totals are unverified.", "observed_result": "No added bleach benefit by ITT; affected-area SCORAD change favored water, -5.7±15.4 versus 0.6±12.4, P=.03", "result_level": "Hon provides the parent same-water-control and clinician-rated severity context. Its 40 completed, 14 nonadherent, no added benefit by ITT and affected-area change of water -5.7±15.4 versus bleach 0.6±12.4, P=.03, are preserved. The colonization question in the original bibliography is not converted into acquired colonization or infection effects and denominators.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/26270469/" } ] }, { "report_id": "R02", "title": "Wong SM, Ng TG, Baba R. Efficacy and safety of sodium hypochlorite (bleach) baths in patients with moderate to severe atopic dermatitis in Malaysia. J Dermatol. 2013. PMID: 24111816. DOI: 10.1111/1346-8138.12265.", "url": "https://pubmed.ncbi.nlm.nih.gov/24111816/", "report_type": "Citation-only bibliography and summary of a concurrent-care trial", "existence": "The stored summary contains a bibliography; acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external materials unread", "study_family": "Shared report links across the parent and subclaims; outcome-specific inclusion, unique counts and independence unverified", "independent_replication": "Hon, Wong and Bakaa are preserved reports shared across the parent and existing subclaims. Hon 40 completed and 14 nonadherent and the review 10 trials and 307 participants retain their original contexts; they are not direct colonization or infection denominators or independent totals. Unique trial, participant and independent-replication totals are unverified.", "observed_result": "The stored citation summary separates an Asian trial with concurrent care.", "result_level": "Wong is a citation-only bibliography and summary of an Asian trial with concurrent care. A separate evidence row and direct colonization or infection effects, CIs and denominators are not linked. The parent 8-week context or Bakaa materials do not fill these gaps.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/24111816/" } ] }, { "report_id": "R03", "title": "Bakaa L, Pernica JM, Couban RJ, et al. Bleach baths for atopic dermatitis: a systematic review and meta-analysis including unpublished data, Bayesian interpretation, and GRADE. Ann Allergy Asthma Immunol. 2022;128:660-668.e9. PMID: 35367346. DOI: 10.1016/j.anai.2022.03.024.", "url": "https://pubmed.ncbi.nlm.nih.gov/35367346/", "report_type": "Review preserved with colonization distinguished from other outcomes", "existence": "The stored summary contains a bibliography; acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external materials unread", "study_family": "Shared report links across the parent and subclaims; outcome-specific inclusion, unique counts and independence unverified", "independent_replication": "Hon, Wong and Bakaa are preserved reports shared across the parent and existing subclaims. Hon 40 completed and 14 nonadherent and the review 10 trials and 307 participants retain their original contexts; they are not direct colonization or infection denominators or independent totals. Unique trial, participant and independent-replication totals are unverified.", "observed_result": "EASI-50 22% versus 32%; ratio of means 0.78 (95% CrI 0.59 to 0.99); colonization RR 0.89 (0.73 to 1.09)", "result_level": "Bakaa 10 trials and 307 participants describe the full review. The colonization RR of 0.89 (0.73 to 1.09) and unestablished clinical infection benefit are retained. EASI-50 of 22% versus 32% and a ratio of means of 0.78 (95% CrI 0.59 to 0.99) provide separate severity context. Colonization interval type, outcome-specific denominators, direct infection values and unpublished-original details are unverified.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. Summary dates belong to the original evidence. Blank external-material dates remain blank; no new external-reading or completed-content-review date is created." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/35367346/" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.", "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.", "Review incomplete": "Review of existing content remains incomplete.", "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.", "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.", "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.", "Not applicable": "Used only with an application exception and reason based on the question scope.", "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.", "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade." }, "study_overlap": { "state": "Unverified", "unique_trial_count": null, "unique_participant_count": null, "reason": "Hon, Wong and Bakaa are preserved reports shared across the parent and existing subclaims. Hon 40 completed and 14 nonadherent and the review 10 trials and 307 participants retain their original contexts; they are not direct colonization or infection denominators or independent totals. Unique trial, participant and independent-replication totals are unverified." }, "history": [ { "date": "2026-10-20", "kind": "Separation of public-facing pages and materials", "view_version": "1.0", "change": "Public-facing views and materials were prepared from the existing 28 items. No new clinical search, verification-status change or scoring was performed." } ], "language": "en", "translation_date": "2026-10-20" }