Green-tea gargling × prevention of clinically defined influenza

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionWhich clinically defined influenza claim is selected?Required	The selection is prevention of clinically defined influenza; preserve subclaim D and the null note HR 0.77 (0.53 to 1.11), P=.16. Parent D with 34 points is separate laboratory-confirmed context. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Selected question, grade, note and parent laboratory-confirmed context	Material needed: Subclaim score, status and axes fields are absent. Do not fill them from parent values or replace this with the laboratory-confirmed endpoint. This records needed materials; no new research was executed.
2	Unverified	Full text not readStored summary read	N02 · Evidence conditionHow was clinically defined influenza defined?Required	The selected note records clinical HR, distinguished from the parent evidence's laboratory-confirmed endpoint. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Symptoms, fever/care, case definition and evaluation/adjudication procedures	Material needed: Exact clinical case criteria, reporting/care, assessors and distinction from other respiratory diseases are unlinked. This records needed materials; no new research was executed.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionWhat is the water-control trial context?Required	The parent Ide trial compares green tea with tap water; water controls also gargled 3 times daily. Preserve the selected wording and do not create a no-gargling trial. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Comparator, arms and added-effect scope linked to the clinical question	Material needed: Arm mapping, comparator conditions and definitions in the original clinical HR table are unlinked. A shared bibliographic link does not become new table verification. This records needed materials; no new research was executed.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionAre parent trial participants and clinical denominators the same?Required	The parent trial records 757 randomized Japanese high-school students and 747 in FAS. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Eligibility, baseline risk and clinical-outcome denominators	Material needed: Analysis populations, arm denominators, age/eligibility and baseline clinical risk for HR are unlinked. Do not automatically transfer laboratory-confirmed denominators 384/363. This records needed materials; no new research was executed.
5	Partly verified	Full text not readStored summary read	N05 · Evidence conditionWhich gargle formulation and exposure were recorded?Required	Parent exposure is green-tea/water gargling 3 times daily for 90 days. Preserve the research record without creating new gargling or prevention instructions. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Products, constituents, concentration, volume, delivery and arm-specific adherence	Material needed: Formulation, concentration, actual exposure, delivery adherence and cross-exposure linked to the clinical outcome are unverified. This records needed materials; no new research was executed.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionWere open allocation and clinical-assessment biases verified?Required	The parent trial is recorded as an open randomized design. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Allocation, concealment, reporting/adjudication and analysis blinding	Material needed: Details of blinding in clinical symptom reporting, care selection, event adjudication and analysis are unlinked. Laboratory-endpoint structures do not replace clinical assessment. This records needed materials; no new research was executed.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionWhere are HR, interval and P recorded?Required	HR 0.77 (0.53 to 1.11), P=.16 comes from the selected clinically defined subclaim note. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Selected note, estimator, arm direction, interval level and analysis	Material needed: Arm mapping, adjustment, model and interval type/level are absent from the note. Do not automatically attach the parent laboratory OR's 95% CI label or adjustment. This records needed materials; no new research was executed.
8	Unverified	Full text not readStored summary read	N08 · Evidence conditionWere HR time origin, risk sets and censoring verified?Required	Preserve the parent trial's 90 days as research context, distinguished from the clinical HR observation window. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Follow-up window, events/person-time, time origin, censoring and model assumptions	Material needed: Clinical HR time origin, censoring/risk sets, recurrent/first events and model assumptions are unlinked. Do not convert HR into cumulative risk or OR. This records needed materials; no new research was executed.
9	Unverified	Full text not readStored summary read	N09 · Evidence conditionWhat are clinical event counts and arm denominators?Required	The selected note contains only HR, interval and P; it provides no clinical event counts. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Clinically defined patients/events, recurrence and assessment denominators	Material needed: Clinical events, patients, arm denominators and observation time cannot be replaced by laboratory-confirmed 19/25 or 384/363. Calculate no new events, rates or effects. This records needed materials; no new research was executed.
10	Unverified	Full text not readStored summary read	N10 · Evidence conditionWere the clinical analysis population and missingness verified?Required	Parent FAS of 747 and PP OR 0.86 (0.44 to 1.69), P=.66 remain laboratory-confirmed analysis context. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	FAS/PP/ITT, symptom/care missingness, exclusions and sensitivity	Material needed: Clinical HR analysis populations, missingness/exclusions, adherence/PP and sensitivity are unlinked. Do not transfer laboratory-confirmed PP to clinical PP. This records needed materials; no new research was executed.
11	Unverified	Full text not readStored summary read	N11 · Evidence conditionWere clinical endpoint hierarchy, multiplicity and registration verified?Required	Original evidence registration wording is NCT01225770; the parent's primary comparison is laboratory-confirmed context. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Prespecified primary/secondary designation, changes and testing plan	Material needed: Clinical hierarchy, multiplicity, changes and original registration/protocol/SAP are unread. Do not promote clinical HR to a new primary endpoint. This records needed materials; no new research was executed.
12	Partly verified	Full text not readStored summary read	N12 · Evidence conditionDoes clinical null mean exact no effect or equivalence?Required	The clinical note records HR 0.77, interval 0.53 to 1.11 and P=.16 as null. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Effect direction, interval, prespecified testing and clinical-importance criteria	Material needed: Do not turn this into exact effect 0, equivalence, certain prevention or a new grade F. Clinical-importance criteria and sample-size plans are unlinked. This records needed materials; no new research was executed.
13	Partly verified	Full text not readStored summary read	N13 · Evidence conditionAre laboratory-confirmed OR/FAS/PP and clinical HR the same result?Required	Preserve laboratory-confirmed 19/384 versus 25/363, adjusted OR 0.69, 95% CI, P=.24 and PP OR/P separately from clinical HR. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Definitions, units, denominators, times and estimators	Material needed: Do not transfer numbers, denominators or analyses between endpoints or count the two results as independent confirmation. This records needed materials; no new research was executed.
14	Unverified	Full text not readStored summary read	N14 · Evidence conditionCan the clinical definition extend to other infections, severity or treatment?Required	The selected question is prevention of clinically defined influenza. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Relationships among clinical cases, laboratory confirmation and other diseases/severity	Material needed: Do not replace the clinical definition with laboratory-confirmed infection, all respiratory diseases, severe disease or treatment effects. Diagnostic correspondence and severe outcomes are unlinked. This records needed materials; no new research was executed.
15	Unverified	Full text not readStored summary read	N15 · Evidence conditionWere concurrent exposure, adherence and prevention comparable?Supplementary	Preserve the parent 90-day trial and high-school population scope. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Existing prevention/vaccination, school exposure, arm-specific delivery and environment	Material needed: Concurrent prevention, exposure, adherence, environment and arm mapping for the selected clinical outcome are unlinked. Create no new infection-prevention or treatment guidance. This records needed materials; no new research was executed.
16	Partly verified	Full text not readStored summary read	N16 · Evidence conditionCan other routes, observations or gargles be combined?Required	The original text did not count drinking, capsules or nursing-home observations as replication and describes povidone-iodine/water in verdict 720 as a different intervention. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Selected gargling/water controls versus drinking, capsules and other gargles	Material needed: These materials were not read now and are not combined as independent replication of the selected clinical HR. This records needed materials; no new research was executed.
17	Unverified	Full text not readStored summary read	N17 · Evidence conditionDo effects persist long term or in other populations?Required	Preserve the parent 90-day high-school trial period. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Parent duration context versus selected clinical follow-up and long-term/other populations	Material needed: The exact clinical HR window, long-term/other-age effects, severe disease/hospitalization and reinfection effects are unlinked. Create no new dosing or prevention instructions. This records needed materials; no new research was executed.
18	Partly verified	Full text not readStored summary read	N18 · Evidence conditionCan the same Ide report be counted as two trials?Required	Both questions share the single parent Ide 2014 bibliography; clinical values link to a subclaim note. Do not turn the same report/population into two trials. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Single bibliography, two subclaim results and report/trial relationships	Material needed: Detailed clinical HR table/report attribution, cohorts and unique/independent totals are unverified. This records needed materials; no new research was executed.
19	Partly verified	Full text not readStored summary read	N19 · Evidence conditionWhat are public funding, product support and COI?Required	Preserve the same parent evidence's Public KAKENHI funding wording. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Distinguishing public funding from products, employees, COI and research roles	Material needed: Support, employee authors, COI and analysis/publication roles are unlinked. Public funding alone does not establish independent confirmation or complete support verification. This records needed materials; no new research was executed.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionDoes no adverse-event reporting establish harm verification?Supplementary	Preserve the parent trial's no-adverse-events-reported statement and Good safety label. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Harms collection, arm events/denominators, timing, stopping and missingness	Material needed: Original collection, arm denominators, missingness/stopping and verification of exactly 0 events are absent. Do not turn clinical null or parent Good into new safety certification. This records needed materials; no new research was executed.
21	Unverified	Full text not readStored summary read	N21 · Evidence conditionWere long-term and vulnerable-population harms verified?Supplementary	Preserve the parent's original cautions as historical context without creating new gargling, infection-prevention or treatment instructions. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Population, exposure, concurrent factors and long-term harm scope	Material needed: Harms by other populations, long-term exposure and alternative causes are unlinked. Nonreporting does not establish no harm. This records needed materials; no new research was executed.
22	Partly verified	Full text not readStored summary read	N22 · Evidence conditionHow are original verdicts, both languages, dates and empty histories preserved?Required	Preserve parent D with 34 points, both languages, axes, 2026-09-07, empty correction/deliberation records and subclaim D with the clinical HR note. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Parent/subclaim, notes, absent score and date distinctions	Material needed: Do not fill absent subclaim score/status/axes from parent values or inherit historical cross-checks as current review/certification. This records needed materials; no new research was executed.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionWhich materials were actually read?Required	Production used complete stored summaries, bibliography and the selected note, distinguishing summary reading from unread external materials. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Report/material links and original registration, plan and support access scope	Material needed: External papers, registration, protocols/SAPs and support originals are unread and access was not attempted. URLs/historical verification do not become current reading or link checks. This records needed materials; no new research was executed.

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23 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-09-07
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: The parent trial records 757 randomized Japanese high-school students and 747 in FAS. This is trial context; arm denominators, events/observation time, eligibility and baseline risk for clinical HR are unlinked. Do not automatically transfer laboratory-confirmed denominators to the clinical outcome.
Ingredient, formulation and route: Preserve the parent green-tea versus tap-water gargling trial context. Products, constituents, concentration, volume, actual delivery and adherence linked to the clinical outcome are unverified. Do not combine drinking, capsules, observational material or other gargles as the same exposure or independent replication, or create new instructions.
Dose: Parent exposure is green-tea/water gargling 3 times daily for 90 days. Do not newly establish quantitative exposure, adherence or an observation window for clinical HR from this context. Calculate no total exposure and create no personal gargling, infection-prevention or treatment instructions.
Comparator: The parent Ide trial compares green tea with tap water; water controls also gargled 3 times daily. Preserve the selected clinically defined question, while original arm mapping and comparator details for clinical HR remain unlinked. Do not turn this into a no-gargling control trial.
Measured outcome: The selected subclaim note records clinically defined influenza HR 0.77 (0.53 to 1.11), P=.16 as null. Clinical definitions, events, denominators, interval type/level, adjustment, model, censoring, hierarchy and original table attribution are unlinked. Distinguish parent laboratory-confirmed OR/FAS/PP and the 95% CI label.
Duration: The parent 90 days is trial context. Exact time origin, risk sets, censoring and observation window for clinical HR are unlinked. Do not extend this into verified long-term, other-age, severe-disease/hospitalization, reinfection or treatment effects.
Questions outside this scope: Transferring laboratory-confirmed events, denominators, OR/FAS/PP, interval level or adjustment to clinical HR; Newly verifying clinical definitions, time origin, censoring, hierarchy or table attribution, or promoting the endpoint to primary; Turning clinical null findings into exact effect 0, equivalence, certain prevention or a new grade F; Counting the two questions or populations from the same Ide report as new independent trials or participant totals; Combining drinking, capsules, observations, other gargles or verdict 720 as replication of the same clinical HR; Inheriting public funding, parent D with 34 points, Good safety or historical verification as subclaim scores or new independence/safety certification; Creating new events, rates, effects, intervals, totals or gargling, infection-prevention or treatment instructions

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

S01 · Ide K, Yamada H, Matsushita K, et al. Effects of Green Tea Gargling on the Prevention of Influenza Infection in High School Students: A Randomized Controlled Study. PLoS One. 2014;9:e96373. PMID: 24836780. PMCID: PMC4023996. DOI: 10.1371/journal.pone.0096373.

PubMed

Material type: Open randomized green-tea versus tap-water trial
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary: HR 0.77 (0.53 to 1.11), P=.16 was null.
Record level: Values from the selected clinically defined subclaim note. Links to original clinical tables, definitions, events, denominators, time origin, interval type/level, adjustment, model, censoring and hierarchy are unverified. Do not substitute the parent bibliography’s laboratory-confirmed results or denominators.
Study overlap and independent replication: Both questions share the same parent Ide bibliography and population; clinical HR is linked to a separate subclaim note. Clinical table/report attribution, cohort details and unique/independent totals are unverified. Do not count endpoints, analyses or sheets as new independent trials or participant totals.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs.
External paper	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs.
Protocol	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs.
Statistical analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs.
Funding, product-support and COI material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs.

Report counts versus independent study counts

Both questions share the same parent Ide bibliography and population; clinical HR is linked to a separate subclaim note. Clinical table/report attribution, cohort details and unique/independent totals are unverified. Do not count endpoints, analyses or sheets as new independent trials or participant totals.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which clinically defined influenza claim is selected?

Required materials and conditions: Selected question, grade, note and parent laboratory-confirmed context
Conditions for verification: Material for Selected question, grade, note and parent laboratory-confirmed context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Selected question, grade, note and parent laboratory-confirmed context with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N02 · How was clinically defined influenza defined?

Required materials and conditions: Symptoms, fever/care, case definition and evaluation/adjudication procedures
Conditions for verification: Material for Symptoms, fever/care, case definition and evaluation/adjudication procedures must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Symptoms, fever/care, case definition and evaluation/adjudication procedures with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N03 · What is the water-control trial context?

Required materials and conditions: Comparator, arms and added-effect scope linked to the clinical question
Conditions for verification: Material for Comparator, arms and added-effect scope linked to the clinical question must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Comparator, arms and added-effect scope linked to the clinical question with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N04 · Are parent trial participants and clinical denominators the same?

Required materials and conditions: Eligibility, baseline risk and clinical-outcome denominators
Conditions for verification: Material for Eligibility, baseline risk and clinical-outcome denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Eligibility, baseline risk and clinical-outcome denominators with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N05 · Which gargle formulation and exposure were recorded?

Required materials and conditions: Products, constituents, concentration, volume, delivery and arm-specific adherence
Conditions for verification: Material for Products, constituents, concentration, volume, delivery and arm-specific adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Products, constituents, concentration, volume, delivery and arm-specific adherence with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N06 · Were open allocation and clinical-assessment biases verified?

Required materials and conditions: Allocation, concealment, reporting/adjudication and analysis blinding
Conditions for verification: Material for Allocation, concealment, reporting/adjudication and analysis blinding must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Allocation, concealment, reporting/adjudication and analysis blinding with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N07 · Where are HR, interval and P recorded?

Required materials and conditions: Selected note, estimator, arm direction, interval level and analysis
Conditions for verification: Material for Selected note, estimator, arm direction, interval level and analysis must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Selected note, estimator, arm direction, interval level and analysis with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N08 · Were HR time origin, risk sets and censoring verified?

Required materials and conditions: Follow-up window, events/person-time, time origin, censoring and model assumptions
Conditions for verification: Material for Follow-up window, events/person-time, time origin, censoring and model assumptions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Follow-up window, events/person-time, time origin, censoring and model assumptions with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N09 · What are clinical event counts and arm denominators?

Required materials and conditions: Clinically defined patients/events, recurrence and assessment denominators
Conditions for verification: Material for Clinically defined patients/events, recurrence and assessment denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Clinically defined patients/events, recurrence and assessment denominators with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N10 · Were the clinical analysis population and missingness verified?

Required materials and conditions: FAS/PP/ITT, symptom/care missingness, exclusions and sensitivity
Conditions for verification: Material for FAS/PP/ITT, symptom/care missingness, exclusions and sensitivity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects FAS/PP/ITT, symptom/care missingness, exclusions and sensitivity with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N11 · Were clinical endpoint hierarchy, multiplicity and registration verified?

Required materials and conditions: Prespecified primary/secondary designation, changes and testing plan
Conditions for verification: Material for Prespecified primary/secondary designation, changes and testing plan must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Prespecified primary/secondary designation, changes and testing plan with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N12 · Does clinical null mean exact no effect or equivalence?

Required materials and conditions: Effect direction, interval, prespecified testing and clinical-importance criteria
Conditions for verification: Material for Effect direction, interval, prespecified testing and clinical-importance criteria must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Effect direction, interval, prespecified testing and clinical-importance criteria with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N13 · Are laboratory-confirmed OR/FAS/PP and clinical HR the same result?

Required materials and conditions: Definitions, units, denominators, times and estimators
Conditions for verification: Material for Definitions, units, denominators, times and estimators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Definitions, units, denominators, times and estimators with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N14 · Can the clinical definition extend to other infections, severity or treatment?

Required materials and conditions: Relationships among clinical cases, laboratory confirmation and other diseases/severity
Conditions for verification: Material for Relationships among clinical cases, laboratory confirmation and other diseases/severity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Relationships among clinical cases, laboratory confirmation and other diseases/severity with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N15 · Were concurrent exposure, adherence and prevention comparable?

Required materials and conditions: Existing prevention/vaccination, school exposure, arm-specific delivery and environment
Conditions for verification: Material for Existing prevention/vaccination, school exposure, arm-specific delivery and environment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Existing prevention/vaccination, school exposure, arm-specific delivery and environment with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N16 · Can other routes, observations or gargles be combined?

Required materials and conditions: Selected gargling/water controls versus drinking, capsules and other gargles
Conditions for verification: Material for Selected gargling/water controls versus drinking, capsules and other gargles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Selected gargling/water controls versus drinking, capsules and other gargles with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N17 · Do effects persist long term or in other populations?

Required materials and conditions: Parent duration context versus selected clinical follow-up and long-term/other populations
Conditions for verification: Material for Parent duration context versus selected clinical follow-up and long-term/other populations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Parent duration context versus selected clinical follow-up and long-term/other populations with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N18 · Can the same Ide report be counted as two trials?

Required materials and conditions: Single bibliography, two subclaim results and report/trial relationships
Conditions for verification: Material for Single bibliography, two subclaim results and report/trial relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Single bibliography, two subclaim results and report/trial relationships with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N19 · What are public funding, product support and COI?

Required materials and conditions: Distinguishing public funding from products, employees, COI and research roles
Conditions for verification: Material for Distinguishing public funding from products, employees, COI and research roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Distinguishing public funding from products, employees, COI and research roles with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N20 · Does no adverse-event reporting establish harm verification?

Required materials and conditions: Harms collection, arm events/denominators, timing, stopping and missingness
Conditions for verification: Material for Harms collection, arm events/denominators, timing, stopping and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Harms collection, arm events/denominators, timing, stopping and missingness with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N21 · Were long-term and vulnerable-population harms verified?

Required materials and conditions: Population, exposure, concurrent factors and long-term harm scope
Conditions for verification: Material for Population, exposure, concurrent factors and long-term harm scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Population, exposure, concurrent factors and long-term harm scope with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N22 · How are original verdicts, both languages, dates and empty histories preserved?

Required materials and conditions: Parent/subclaim, notes, absent score and date distinctions
Conditions for verification: Material for Parent/subclaim, notes, absent score and date distinctions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Parent/subclaim, notes, absent score and date distinctions with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N23 · Which materials were actually read?

Required materials and conditions: Report/material links and original registration, plan and support access scope
Conditions for verification: Material for Report/material links and original registration, plan and support access scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Report/material links and original registration, plan and support access scope with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

What the statuses mean

Met: A state used when required evidence is confirmed after user review. This production does not declare that review complete.
Partly verified: Some information in the stored summary is linked into the table. External comparison/content review is not complete.
Unverified: The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.
Review incomplete: User review pending.
Not reported: Not reported within the stored material actually read; not extended to the entire primary paper.
Inaccessible: Means an actual access failure. Access not attempted here is not assigned this state.
Not applicable: Not used as a substitute for an evidence gap.
Conflicting data: Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.
Insufficient evidence for the conditions: Marks a gap in additional material required by the selected conditions; not a new efficacy grade.

Change history

2026-10-19 · Public page/material version 1.0

Reader pages and materials were prepared from the existing 23 items. No new clinical search, change in verification status or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-09-07) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which clinically defined influenza claim is selected?

Current findings: The selection is prevention of clinically defined influenza; preserve subclaim D and the null note HR 0.77 (0.53 to 1.11), P=.16. Parent D with 34 points is separate laboratory-confirmed context.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Subclaim score, status and axes fields are absent. Do not fill them from parent values or replace this with the laboratory-confirmed endpoint.
Required materials and conditions: Selected question, grade, note and parent laboratory-confirmed context
Materials to obtain first: Subclaim score, status and axes fields are absent. Do not fill them from parent values or replace this with the laboratory-confirmed endpoint.
Further research: Material needed: Subclaim score, status and axes fields are absent. Do not fill them from parent values or replace this with the laboratory-confirmed endpoint. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Selected question, grade, note and parent laboratory-confirmed context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Selected question, grade, note and parent laboratory-confirmed context with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N02 · How was clinically defined influenza defined?

Current findings: The selected note records clinical HR, distinguished from the parent evidence's laboratory-confirmed endpoint.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Exact clinical case criteria, reporting/care, assessors and distinction from other respiratory diseases are unlinked.
Required materials and conditions: Symptoms, fever/care, case definition and evaluation/adjudication procedures
Materials to obtain first: Exact clinical case criteria, reporting/care, assessors and distinction from other respiratory diseases are unlinked.
Further research: Material needed: Exact clinical case criteria, reporting/care, assessors and distinction from other respiratory diseases are unlinked. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Symptoms, fever/care, case definition and evaluation/adjudication procedures must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Symptoms, fever/care, case definition and evaluation/adjudication procedures with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N03 · What is the water-control trial context?

Current findings: The parent Ide trial compares green tea with tap water; water controls also gargled 3 times daily. Preserve the selected wording and do not create a no-gargling trial.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm mapping, comparator conditions and definitions in the original clinical HR table are unlinked. A shared bibliographic link does not become new table verification.
Required materials and conditions: Comparator, arms and added-effect scope linked to the clinical question
Materials to obtain first: Arm mapping, comparator conditions and definitions in the original clinical HR table are unlinked. A shared bibliographic link does not become new table verification.
Further research: Material needed: Arm mapping, comparator conditions and definitions in the original clinical HR table are unlinked. A shared bibliographic link does not become new table verification. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Comparator, arms and added-effect scope linked to the clinical question must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Comparator, arms and added-effect scope linked to the clinical question with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N04 · Are parent trial participants and clinical denominators the same?

Current findings: The parent trial records 757 randomized Japanese high-school students and 747 in FAS.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Analysis populations, arm denominators, age/eligibility and baseline clinical risk for HR are unlinked. Do not automatically transfer laboratory-confirmed denominators 384/363.
Required materials and conditions: Eligibility, baseline risk and clinical-outcome denominators
Materials to obtain first: Analysis populations, arm denominators, age/eligibility and baseline clinical risk for HR are unlinked. Do not automatically transfer laboratory-confirmed denominators 384/363.
Further research: Material needed: Analysis populations, arm denominators, age/eligibility and baseline clinical risk for HR are unlinked. Do not automatically transfer laboratory-confirmed denominators 384/363. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Eligibility, baseline risk and clinical-outcome denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Eligibility, baseline risk and clinical-outcome denominators with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N05 · Which gargle formulation and exposure were recorded?

Current findings: Parent exposure is green-tea/water gargling 3 times daily for 90 days. Preserve the research record without creating new gargling or prevention instructions.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Formulation, concentration, actual exposure, delivery adherence and cross-exposure linked to the clinical outcome are unverified.
Required materials and conditions: Products, constituents, concentration, volume, delivery and arm-specific adherence
Materials to obtain first: Formulation, concentration, actual exposure, delivery adherence and cross-exposure linked to the clinical outcome are unverified.
Further research: Material needed: Formulation, concentration, actual exposure, delivery adherence and cross-exposure linked to the clinical outcome are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Products, constituents, concentration, volume, delivery and arm-specific adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Products, constituents, concentration, volume, delivery and arm-specific adherence with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N06 · Were open allocation and clinical-assessment biases verified?

Current findings: The parent trial is recorded as an open randomized design.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Details of blinding in clinical symptom reporting, care selection, event adjudication and analysis are unlinked. Laboratory-endpoint structures do not replace clinical assessment.
Required materials and conditions: Allocation, concealment, reporting/adjudication and analysis blinding
Materials to obtain first: Details of blinding in clinical symptom reporting, care selection, event adjudication and analysis are unlinked. Laboratory-endpoint structures do not replace clinical assessment.
Further research: Material needed: Details of blinding in clinical symptom reporting, care selection, event adjudication and analysis are unlinked. Laboratory-endpoint structures do not replace clinical assessment. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Allocation, concealment, reporting/adjudication and analysis blinding must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Allocation, concealment, reporting/adjudication and analysis blinding with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N07 · Where are HR, interval and P recorded?

Current findings: HR 0.77 (0.53 to 1.11), P=.16 comes from the selected clinically defined subclaim note.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm mapping, adjustment, model and interval type/level are absent from the note. Do not automatically attach the parent laboratory OR's 95% CI label or adjustment.
Required materials and conditions: Selected note, estimator, arm direction, interval level and analysis
Materials to obtain first: Arm mapping, adjustment, model and interval type/level are absent from the note. Do not automatically attach the parent laboratory OR's 95% CI label or adjustment.
Further research: Material needed: Arm mapping, adjustment, model and interval type/level are absent from the note. Do not automatically attach the parent laboratory OR's 95% CI label or adjustment. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Selected note, estimator, arm direction, interval level and analysis must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Selected note, estimator, arm direction, interval level and analysis with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N08 · Were HR time origin, risk sets and censoring verified?

Current findings: Preserve the parent trial's 90 days as research context, distinguished from the clinical HR observation window.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Clinical HR time origin, censoring/risk sets, recurrent/first events and model assumptions are unlinked. Do not convert HR into cumulative risk or OR.
Required materials and conditions: Follow-up window, events/person-time, time origin, censoring and model assumptions
Materials to obtain first: Clinical HR time origin, censoring/risk sets, recurrent/first events and model assumptions are unlinked. Do not convert HR into cumulative risk or OR.
Further research: Material needed: Clinical HR time origin, censoring/risk sets, recurrent/first events and model assumptions are unlinked. Do not convert HR into cumulative risk or OR. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Follow-up window, events/person-time, time origin, censoring and model assumptions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Follow-up window, events/person-time, time origin, censoring and model assumptions with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N09 · What are clinical event counts and arm denominators?

Current findings: The selected note contains only HR, interval and P; it provides no clinical event counts.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Clinical events, patients, arm denominators and observation time cannot be replaced by laboratory-confirmed 19/25 or 384/363. Calculate no new events, rates or effects.
Required materials and conditions: Clinically defined patients/events, recurrence and assessment denominators
Materials to obtain first: Clinical events, patients, arm denominators and observation time cannot be replaced by laboratory-confirmed 19/25 or 384/363. Calculate no new events, rates or effects.
Further research: Material needed: Clinical events, patients, arm denominators and observation time cannot be replaced by laboratory-confirmed 19/25 or 384/363. Calculate no new events, rates or effects. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Clinically defined patients/events, recurrence and assessment denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Clinically defined patients/events, recurrence and assessment denominators with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N10 · Were the clinical analysis population and missingness verified?

Current findings: Parent FAS of 747 and PP OR 0.86 (0.44 to 1.69), P=.66 remain laboratory-confirmed analysis context.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Clinical HR analysis populations, missingness/exclusions, adherence/PP and sensitivity are unlinked. Do not transfer laboratory-confirmed PP to clinical PP.
Required materials and conditions: FAS/PP/ITT, symptom/care missingness, exclusions and sensitivity
Materials to obtain first: Clinical HR analysis populations, missingness/exclusions, adherence/PP and sensitivity are unlinked. Do not transfer laboratory-confirmed PP to clinical PP.
Further research: Material needed: Clinical HR analysis populations, missingness/exclusions, adherence/PP and sensitivity are unlinked. Do not transfer laboratory-confirmed PP to clinical PP. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for FAS/PP/ITT, symptom/care missingness, exclusions and sensitivity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects FAS/PP/ITT, symptom/care missingness, exclusions and sensitivity with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N11 · Were clinical endpoint hierarchy, multiplicity and registration verified?

Current findings: Original evidence registration wording is NCT01225770; the parent's primary comparison is laboratory-confirmed context.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Clinical hierarchy, multiplicity, changes and original registration/protocol/SAP are unread. Do not promote clinical HR to a new primary endpoint.
Required materials and conditions: Prespecified primary/secondary designation, changes and testing plan
Materials to obtain first: Clinical hierarchy, multiplicity, changes and original registration/protocol/SAP are unread. Do not promote clinical HR to a new primary endpoint.
Further research: Material needed: Clinical hierarchy, multiplicity, changes and original registration/protocol/SAP are unread. Do not promote clinical HR to a new primary endpoint. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Prespecified primary/secondary designation, changes and testing plan must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Prespecified primary/secondary designation, changes and testing plan with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N12 · Does clinical null mean exact no effect or equivalence?

Current findings: The clinical note records HR 0.77, interval 0.53 to 1.11 and P=.16 as null.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Do not turn this into exact effect 0, equivalence, certain prevention or a new grade F. Clinical-importance criteria and sample-size plans are unlinked.
Required materials and conditions: Effect direction, interval, prespecified testing and clinical-importance criteria
Materials to obtain first: Do not turn this into exact effect 0, equivalence, certain prevention or a new grade F. Clinical-importance criteria and sample-size plans are unlinked.
Further research: Material needed: Do not turn this into exact effect 0, equivalence, certain prevention or a new grade F. Clinical-importance criteria and sample-size plans are unlinked. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Effect direction, interval, prespecified testing and clinical-importance criteria must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Effect direction, interval, prespecified testing and clinical-importance criteria with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N13 · Are laboratory-confirmed OR/FAS/PP and clinical HR the same result?

Current findings: Preserve laboratory-confirmed 19/384 versus 25/363, adjusted OR 0.69, 95% CI, P=.24 and PP OR/P separately from clinical HR.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Do not transfer numbers, denominators or analyses between endpoints or count the two results as independent confirmation.
Required materials and conditions: Definitions, units, denominators, times and estimators
Materials to obtain first: Do not transfer numbers, denominators or analyses between endpoints or count the two results as independent confirmation.
Further research: Material needed: Do not transfer numbers, denominators or analyses between endpoints or count the two results as independent confirmation. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Definitions, units, denominators, times and estimators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Definitions, units, denominators, times and estimators with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N14 · Can the clinical definition extend to other infections, severity or treatment?

Current findings: The selected question is prevention of clinically defined influenza.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Do not replace the clinical definition with laboratory-confirmed infection, all respiratory diseases, severe disease or treatment effects. Diagnostic correspondence and severe outcomes are unlinked.
Required materials and conditions: Relationships among clinical cases, laboratory confirmation and other diseases/severity
Materials to obtain first: Do not replace the clinical definition with laboratory-confirmed infection, all respiratory diseases, severe disease or treatment effects. Diagnostic correspondence and severe outcomes are unlinked.
Further research: Material needed: Do not replace the clinical definition with laboratory-confirmed infection, all respiratory diseases, severe disease or treatment effects. Diagnostic correspondence and severe outcomes are unlinked. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Relationships among clinical cases, laboratory confirmation and other diseases/severity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Relationships among clinical cases, laboratory confirmation and other diseases/severity with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N15 · Were concurrent exposure, adherence and prevention comparable?

Current findings: Preserve the parent 90-day trial and high-school population scope.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Concurrent prevention, exposure, adherence, environment and arm mapping for the selected clinical outcome are unlinked. Create no new infection-prevention or treatment guidance.
Required materials and conditions: Existing prevention/vaccination, school exposure, arm-specific delivery and environment
Materials to obtain first: Concurrent prevention, exposure, adherence, environment and arm mapping for the selected clinical outcome are unlinked. Create no new infection-prevention or treatment guidance.
Further research: Material needed: Concurrent prevention, exposure, adherence, environment and arm mapping for the selected clinical outcome are unlinked. Create no new infection-prevention or treatment guidance. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Existing prevention/vaccination, school exposure, arm-specific delivery and environment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Existing prevention/vaccination, school exposure, arm-specific delivery and environment with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N16 · Can other routes, observations or gargles be combined?

Current findings: The original text did not count drinking, capsules or nursing-home observations as replication and describes povidone-iodine/water in verdict 720 as a different intervention.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: These materials were not read now and are not combined as independent replication of the selected clinical HR.
Required materials and conditions: Selected gargling/water controls versus drinking, capsules and other gargles
Materials to obtain first: These materials were not read now and are not combined as independent replication of the selected clinical HR.
Further research: Material needed: These materials were not read now and are not combined as independent replication of the selected clinical HR. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Selected gargling/water controls versus drinking, capsules and other gargles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Selected gargling/water controls versus drinking, capsules and other gargles with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N17 · Do effects persist long term or in other populations?

Current findings: Preserve the parent 90-day high-school trial period.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: The exact clinical HR window, long-term/other-age effects, severe disease/hospitalization and reinfection effects are unlinked. Create no new dosing or prevention instructions.
Required materials and conditions: Parent duration context versus selected clinical follow-up and long-term/other populations
Materials to obtain first: The exact clinical HR window, long-term/other-age effects, severe disease/hospitalization and reinfection effects are unlinked. Create no new dosing or prevention instructions.
Further research: Material needed: The exact clinical HR window, long-term/other-age effects, severe disease/hospitalization and reinfection effects are unlinked. Create no new dosing or prevention instructions. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Parent duration context versus selected clinical follow-up and long-term/other populations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Parent duration context versus selected clinical follow-up and long-term/other populations with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N18 · Can the same Ide report be counted as two trials?

Current findings: Both questions share the single parent Ide 2014 bibliography; clinical values link to a subclaim note. Do not turn the same report/population into two trials.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Detailed clinical HR table/report attribution, cohorts and unique/independent totals are unverified.
Required materials and conditions: Single bibliography, two subclaim results and report/trial relationships
Materials to obtain first: Detailed clinical HR table/report attribution, cohorts and unique/independent totals are unverified.
Further research: Material needed: Detailed clinical HR table/report attribution, cohorts and unique/independent totals are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Single bibliography, two subclaim results and report/trial relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Single bibliography, two subclaim results and report/trial relationships with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N19 · What are public funding, product support and COI?

Current findings: Preserve the same parent evidence's Public KAKENHI funding wording.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Support, employee authors, COI and analysis/publication roles are unlinked. Public funding alone does not establish independent confirmation or complete support verification.
Required materials and conditions: Distinguishing public funding from products, employees, COI and research roles
Materials to obtain first: Support, employee authors, COI and analysis/publication roles are unlinked. Public funding alone does not establish independent confirmation or complete support verification.
Further research: Material needed: Support, employee authors, COI and analysis/publication roles are unlinked. Public funding alone does not establish independent confirmation or complete support verification. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Distinguishing public funding from products, employees, COI and research roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Distinguishing public funding from products, employees, COI and research roles with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N20 · Does no adverse-event reporting establish harm verification?

Current findings: Preserve the parent trial's no-adverse-events-reported statement and Good safety label.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original collection, arm denominators, missingness/stopping and verification of exactly 0 events are absent. Do not turn clinical null or parent Good into new safety certification.
Required materials and conditions: Harms collection, arm events/denominators, timing, stopping and missingness
Materials to obtain first: Original collection, arm denominators, missingness/stopping and verification of exactly 0 events are absent. Do not turn clinical null or parent Good into new safety certification.
Further research: Material needed: Original collection, arm denominators, missingness/stopping and verification of exactly 0 events are absent. Do not turn clinical null or parent Good into new safety certification. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Harms collection, arm events/denominators, timing, stopping and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Harms collection, arm events/denominators, timing, stopping and missingness with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

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N21 · Were long-term and vulnerable-population harms verified?

Current findings: Preserve the parent's original cautions as historical context without creating new gargling, infection-prevention or treatment instructions.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Harms by other populations, long-term exposure and alternative causes are unlinked. Nonreporting does not establish no harm.
Required materials and conditions: Population, exposure, concurrent factors and long-term harm scope
Materials to obtain first: Harms by other populations, long-term exposure and alternative causes are unlinked. Nonreporting does not establish no harm.
Further research: Material needed: Harms by other populations, long-term exposure and alternative causes are unlinked. Nonreporting does not establish no harm. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Population, exposure, concurrent factors and long-term harm scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Population, exposure, concurrent factors and long-term harm scope with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N22 · How are original verdicts, both languages, dates and empty histories preserved?

Current findings: Preserve parent D with 34 points, both languages, axes, 2026-09-07, empty correction/deliberation records and subclaim D with the clinical HR note.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Do not fill absent subclaim score/status/axes from parent values or inherit historical cross-checks as current review/certification.
Required materials and conditions: Parent/subclaim, notes, absent score and date distinctions
Materials to obtain first: Do not fill absent subclaim score/status/axes from parent values or inherit historical cross-checks as current review/certification.
Further research: Material needed: Do not fill absent subclaim score/status/axes from parent values or inherit historical cross-checks as current review/certification. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Parent/subclaim, notes, absent score and date distinctions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Parent/subclaim, notes, absent score and date distinctions with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N23 · Which materials were actually read?

Current findings: Production used complete stored summaries, bibliography and the selected note, distinguishing summary reading from unread external materials.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: External papers, registration, protocols/SAPs and support originals are unread and access was not attempted. URLs/historical verification do not become current reading or link checks.
Required materials and conditions: Report/material links and original registration, plan and support access scope
Materials to obtain first: External papers, registration, protocols/SAPs and support originals are unread and access was not attempted. URLs/historical verification do not become current reading or link checks.
Further research: Material needed: External papers, registration, protocols/SAPs and support originals are unread and access was not attempted. URLs/historical verification do not become current reading or link checks. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Report/material links and original registration, plan and support access scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Report/material links and original registration, plan and support access scope with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.
Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01