# Green-tea gargling × prevention of clinically defined influenza Verdict 3003 · Evidence Check Stored-material review date: Not recorded Original evidence cut-off: 2026-09-07 Review-criteria version: 1.0 Public page/material preparation date: 2026-10-19 Clinical papers were not read directly; existing review summaries were checked. No new clinical-literature search was performed. Unverified does not mean that research is absent or that there is no effect. ## Assessment scope - Population: The parent trial records 757 randomized Japanese high-school students and 747 in FAS. This is trial context; arm denominators, events/observation time, eligibility and baseline risk for clinical HR are unlinked. Do not automatically transfer laboratory-confirmed denominators to the clinical outcome. - Ingredient, formulation and route: Preserve the parent green-tea versus tap-water gargling trial context. Products, constituents, concentration, volume, actual delivery and adherence linked to the clinical outcome are unverified. Do not combine drinking, capsules, observational material or other gargles as the same exposure or independent replication, or create new instructions. - Dose: Parent exposure is green-tea/water gargling 3 times daily for 90 days. Do not newly establish quantitative exposure, adherence or an observation window for clinical HR from this context. Calculate no total exposure and create no personal gargling, infection-prevention or treatment instructions. - Comparator: The parent Ide trial compares green tea with tap water; water controls also gargled 3 times daily. Preserve the selected clinically defined question, while original arm mapping and comparator details for clinical HR remain unlinked. Do not turn this into a no-gargling control trial. - Measured outcome: The selected subclaim note records clinically defined influenza HR 0.77 (0.53 to 1.11), P=.16 as null. Clinical definitions, events, denominators, interval type/level, adjustment, model, censoring, hierarchy and original table attribution are unlinked. Distinguish parent laboratory-confirmed OR/FAS/PP and the 95% CI label. - Duration: The parent 90 days is trial context. Exact time origin, risk sets, censoring and observation window for clinical HR are unlinked. Do not extend this into verified long-term, other-age, severe-disease/hospitalization, reinfection or treatment effects. - Questions outside this scope: Transferring laboratory-confirmed events, denominators, OR/FAS/PP, interval level or adjustment to clinical HR; Newly verifying clinical definitions, time origin, censoring, hierarchy or table attribution, or promoting the endpoint to primary; Turning clinical null findings into exact effect 0, equivalence, certain prevention or a new grade F; Counting the two questions or populations from the same Ide report as new independent trials or participant totals; Combining drinking, capsules, observations, other gargles or verdict 720 as replication of the same clinical HR; Inheriting public funding, parent D with 34 points, Good safety or historical verification as subclaim scores or new independence/safety certification; Creating new events, rates, effects, intervals, totals or gargling, infection-prevention or treatment instructions ## Checklist items ### N01 · Which clinically defined influenza claim is selected? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The selection is prevention of clinically defined influenza; preserve subclaim D and the null note HR 0.77 (0.53 to 1.11), P=.16. Parent D with 34 points is separate laboratory-confirmed context. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Subclaim score, status and axes fields are absent. Do not fill them from parent values or replace this with the laboratory-confirmed endpoint. - Required materials and conditions: Selected question, grade, note and parent laboratory-confirmed context - Materials to obtain first: Subclaim score, status and axes fields are absent. Do not fill them from parent values or replace this with the laboratory-confirmed endpoint. - Further research: Material needed: Subclaim score, status and axes fields are absent. Do not fill them from parent values or replace this with the laboratory-confirmed endpoint. This records needed materials; no new research was executed. - Conditions for verification: Material for Selected question, grade, note and parent laboratory-confirmed context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Selected question, grade, note and parent laboratory-confirmed context with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N02 · How was clinically defined influenza defined? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The selected note records clinical HR, distinguished from the parent evidence's laboratory-confirmed endpoint. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Exact clinical case criteria, reporting/care, assessors and distinction from other respiratory diseases are unlinked. - Required materials and conditions: Symptoms, fever/care, case definition and evaluation/adjudication procedures - Materials to obtain first: Exact clinical case criteria, reporting/care, assessors and distinction from other respiratory diseases are unlinked. - Further research: Material needed: Exact clinical case criteria, reporting/care, assessors and distinction from other respiratory diseases are unlinked. This records needed materials; no new research was executed. - Conditions for verification: Material for Symptoms, fever/care, case definition and evaluation/adjudication procedures must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Symptoms, fever/care, case definition and evaluation/adjudication procedures with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N03 · What is the water-control trial context? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The parent Ide trial compares green tea with tap water; water controls also gargled 3 times daily. Preserve the selected wording and do not create a no-gargling trial. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Arm mapping, comparator conditions and definitions in the original clinical HR table are unlinked. A shared bibliographic link does not become new table verification. - Required materials and conditions: Comparator, arms and added-effect scope linked to the clinical question - Materials to obtain first: Arm mapping, comparator conditions and definitions in the original clinical HR table are unlinked. A shared bibliographic link does not become new table verification. - Further research: Material needed: Arm mapping, comparator conditions and definitions in the original clinical HR table are unlinked. A shared bibliographic link does not become new table verification. This records needed materials; no new research was executed. - Conditions for verification: Material for Comparator, arms and added-effect scope linked to the clinical question must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Comparator, arms and added-effect scope linked to the clinical question with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N04 · Are parent trial participants and clinical denominators the same? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The parent trial records 757 randomized Japanese high-school students and 747 in FAS. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Analysis populations, arm denominators, age/eligibility and baseline clinical risk for HR are unlinked. Do not automatically transfer laboratory-confirmed denominators 384/363. - Required materials and conditions: Eligibility, baseline risk and clinical-outcome denominators - Materials to obtain first: Analysis populations, arm denominators, age/eligibility and baseline clinical risk for HR are unlinked. Do not automatically transfer laboratory-confirmed denominators 384/363. - Further research: Material needed: Analysis populations, arm denominators, age/eligibility and baseline clinical risk for HR are unlinked. Do not automatically transfer laboratory-confirmed denominators 384/363. This records needed materials; no new research was executed. - Conditions for verification: Material for Eligibility, baseline risk and clinical-outcome denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Eligibility, baseline risk and clinical-outcome denominators with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N05 · Which gargle formulation and exposure were recorded? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Parent exposure is green-tea/water gargling 3 times daily for 90 days. Preserve the research record without creating new gargling or prevention instructions. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Formulation, concentration, actual exposure, delivery adherence and cross-exposure linked to the clinical outcome are unverified. - Required materials and conditions: Products, constituents, concentration, volume, delivery and arm-specific adherence - Materials to obtain first: Formulation, concentration, actual exposure, delivery adherence and cross-exposure linked to the clinical outcome are unverified. - Further research: Material needed: Formulation, concentration, actual exposure, delivery adherence and cross-exposure linked to the clinical outcome are unverified. This records needed materials; no new research was executed. - Conditions for verification: Material for Products, constituents, concentration, volume, delivery and arm-specific adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Products, constituents, concentration, volume, delivery and arm-specific adherence with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N06 · Were open allocation and clinical-assessment biases verified? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The parent trial is recorded as an open randomized design. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Details of blinding in clinical symptom reporting, care selection, event adjudication and analysis are unlinked. Laboratory-endpoint structures do not replace clinical assessment. - Required materials and conditions: Allocation, concealment, reporting/adjudication and analysis blinding - Materials to obtain first: Details of blinding in clinical symptom reporting, care selection, event adjudication and analysis are unlinked. Laboratory-endpoint structures do not replace clinical assessment. - Further research: Material needed: Details of blinding in clinical symptom reporting, care selection, event adjudication and analysis are unlinked. Laboratory-endpoint structures do not replace clinical assessment. This records needed materials; no new research was executed. - Conditions for verification: Material for Allocation, concealment, reporting/adjudication and analysis blinding must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Allocation, concealment, reporting/adjudication and analysis blinding with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N07 · Where are HR, interval and P recorded? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: HR 0.77 (0.53 to 1.11), P=.16 comes from the selected clinically defined subclaim note. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Arm mapping, adjustment, model and interval type/level are absent from the note. Do not automatically attach the parent laboratory OR's 95% CI label or adjustment. - Required materials and conditions: Selected note, estimator, arm direction, interval level and analysis - Materials to obtain first: Arm mapping, adjustment, model and interval type/level are absent from the note. Do not automatically attach the parent laboratory OR's 95% CI label or adjustment. - Further research: Material needed: Arm mapping, adjustment, model and interval type/level are absent from the note. Do not automatically attach the parent laboratory OR's 95% CI label or adjustment. This records needed materials; no new research was executed. - Conditions for verification: Material for Selected note, estimator, arm direction, interval level and analysis must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Selected note, estimator, arm direction, interval level and analysis with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N08 · Were HR time origin, risk sets and censoring verified? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve the parent trial's 90 days as research context, distinguished from the clinical HR observation window. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Clinical HR time origin, censoring/risk sets, recurrent/first events and model assumptions are unlinked. Do not convert HR into cumulative risk or OR. - Required materials and conditions: Follow-up window, events/person-time, time origin, censoring and model assumptions - Materials to obtain first: Clinical HR time origin, censoring/risk sets, recurrent/first events and model assumptions are unlinked. Do not convert HR into cumulative risk or OR. - Further research: Material needed: Clinical HR time origin, censoring/risk sets, recurrent/first events and model assumptions are unlinked. Do not convert HR into cumulative risk or OR. This records needed materials; no new research was executed. - Conditions for verification: Material for Follow-up window, events/person-time, time origin, censoring and model assumptions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Follow-up window, events/person-time, time origin, censoring and model assumptions with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N09 · What are clinical event counts and arm denominators? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The selected note contains only HR, interval and P; it provides no clinical event counts. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Clinical events, patients, arm denominators and observation time cannot be replaced by laboratory-confirmed 19/25 or 384/363. Calculate no new events, rates or effects. - Required materials and conditions: Clinically defined patients/events, recurrence and assessment denominators - Materials to obtain first: Clinical events, patients, arm denominators and observation time cannot be replaced by laboratory-confirmed 19/25 or 384/363. Calculate no new events, rates or effects. - Further research: Material needed: Clinical events, patients, arm denominators and observation time cannot be replaced by laboratory-confirmed 19/25 or 384/363. Calculate no new events, rates or effects. This records needed materials; no new research was executed. - Conditions for verification: Material for Clinically defined patients/events, recurrence and assessment denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Clinically defined patients/events, recurrence and assessment denominators with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N10 · Were the clinical analysis population and missingness verified? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Parent FAS of 747 and PP OR 0.86 (0.44 to 1.69), P=.66 remain laboratory-confirmed analysis context. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Clinical HR analysis populations, missingness/exclusions, adherence/PP and sensitivity are unlinked. Do not transfer laboratory-confirmed PP to clinical PP. - Required materials and conditions: FAS/PP/ITT, symptom/care missingness, exclusions and sensitivity - Materials to obtain first: Clinical HR analysis populations, missingness/exclusions, adherence/PP and sensitivity are unlinked. Do not transfer laboratory-confirmed PP to clinical PP. - Further research: Material needed: Clinical HR analysis populations, missingness/exclusions, adherence/PP and sensitivity are unlinked. Do not transfer laboratory-confirmed PP to clinical PP. This records needed materials; no new research was executed. - Conditions for verification: Material for FAS/PP/ITT, symptom/care missingness, exclusions and sensitivity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects FAS/PP/ITT, symptom/care missingness, exclusions and sensitivity with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N11 · Were clinical endpoint hierarchy, multiplicity and registration verified? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original evidence registration wording is NCT01225770; the parent's primary comparison is laboratory-confirmed context. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Clinical hierarchy, multiplicity, changes and original registration/protocol/SAP are unread. Do not promote clinical HR to a new primary endpoint. - Required materials and conditions: Prespecified primary/secondary designation, changes and testing plan - Materials to obtain first: Clinical hierarchy, multiplicity, changes and original registration/protocol/SAP are unread. Do not promote clinical HR to a new primary endpoint. - Further research: Material needed: Clinical hierarchy, multiplicity, changes and original registration/protocol/SAP are unread. Do not promote clinical HR to a new primary endpoint. This records needed materials; no new research was executed. - Conditions for verification: Material for Prespecified primary/secondary designation, changes and testing plan must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Prespecified primary/secondary designation, changes and testing plan with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N12 · Does clinical null mean exact no effect or equivalence? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The clinical note records HR 0.77, interval 0.53 to 1.11 and P=.16 as null. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Do not turn this into exact effect 0, equivalence, certain prevention or a new grade F. Clinical-importance criteria and sample-size plans are unlinked. - Required materials and conditions: Effect direction, interval, prespecified testing and clinical-importance criteria - Materials to obtain first: Do not turn this into exact effect 0, equivalence, certain prevention or a new grade F. Clinical-importance criteria and sample-size plans are unlinked. - Further research: Material needed: Do not turn this into exact effect 0, equivalence, certain prevention or a new grade F. Clinical-importance criteria and sample-size plans are unlinked. This records needed materials; no new research was executed. - Conditions for verification: Material for Effect direction, interval, prespecified testing and clinical-importance criteria must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Effect direction, interval, prespecified testing and clinical-importance criteria with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N13 · Are laboratory-confirmed OR/FAS/PP and clinical HR the same result? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve laboratory-confirmed 19/384 versus 25/363, adjusted OR 0.69, 95% CI, P=.24 and PP OR/P separately from clinical HR. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Do not transfer numbers, denominators or analyses between endpoints or count the two results as independent confirmation. - Required materials and conditions: Definitions, units, denominators, times and estimators - Materials to obtain first: Do not transfer numbers, denominators or analyses between endpoints or count the two results as independent confirmation. - Further research: Material needed: Do not transfer numbers, denominators or analyses between endpoints or count the two results as independent confirmation. This records needed materials; no new research was executed. - Conditions for verification: Material for Definitions, units, denominators, times and estimators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Definitions, units, denominators, times and estimators with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N14 · Can the clinical definition extend to other infections, severity or treatment? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The selected question is prevention of clinically defined influenza. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Do not replace the clinical definition with laboratory-confirmed infection, all respiratory diseases, severe disease or treatment effects. Diagnostic correspondence and severe outcomes are unlinked. - Required materials and conditions: Relationships among clinical cases, laboratory confirmation and other diseases/severity - Materials to obtain first: Do not replace the clinical definition with laboratory-confirmed infection, all respiratory diseases, severe disease or treatment effects. Diagnostic correspondence and severe outcomes are unlinked. - Further research: Material needed: Do not replace the clinical definition with laboratory-confirmed infection, all respiratory diseases, severe disease or treatment effects. Diagnostic correspondence and severe outcomes are unlinked. This records needed materials; no new research was executed. - Conditions for verification: Material for Relationships among clinical cases, laboratory confirmation and other diseases/severity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Relationships among clinical cases, laboratory confirmation and other diseases/severity with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N15 · Were concurrent exposure, adherence and prevention comparable? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve the parent 90-day trial and high-school population scope. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Concurrent prevention, exposure, adherence, environment and arm mapping for the selected clinical outcome are unlinked. Create no new infection-prevention or treatment guidance. - Required materials and conditions: Existing prevention/vaccination, school exposure, arm-specific delivery and environment - Materials to obtain first: Concurrent prevention, exposure, adherence, environment and arm mapping for the selected clinical outcome are unlinked. Create no new infection-prevention or treatment guidance. - Further research: Material needed: Concurrent prevention, exposure, adherence, environment and arm mapping for the selected clinical outcome are unlinked. Create no new infection-prevention or treatment guidance. This records needed materials; no new research was executed. - Conditions for verification: Material for Existing prevention/vaccination, school exposure, arm-specific delivery and environment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Existing prevention/vaccination, school exposure, arm-specific delivery and environment with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N16 · Can other routes, observations or gargles be combined? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The original text did not count drinking, capsules or nursing-home observations as replication and describes povidone-iodine/water in verdict 720 as a different intervention. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: These materials were not read now and are not combined as independent replication of the selected clinical HR. - Required materials and conditions: Selected gargling/water controls versus drinking, capsules and other gargles - Materials to obtain first: These materials were not read now and are not combined as independent replication of the selected clinical HR. - Further research: Material needed: These materials were not read now and are not combined as independent replication of the selected clinical HR. This records needed materials; no new research was executed. - Conditions for verification: Material for Selected gargling/water controls versus drinking, capsules and other gargles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Selected gargling/water controls versus drinking, capsules and other gargles with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N17 · Do effects persist long term or in other populations? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve the parent 90-day high-school trial period. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: The exact clinical HR window, long-term/other-age effects, severe disease/hospitalization and reinfection effects are unlinked. Create no new dosing or prevention instructions. - Required materials and conditions: Parent duration context versus selected clinical follow-up and long-term/other populations - Materials to obtain first: The exact clinical HR window, long-term/other-age effects, severe disease/hospitalization and reinfection effects are unlinked. Create no new dosing or prevention instructions. - Further research: Material needed: The exact clinical HR window, long-term/other-age effects, severe disease/hospitalization and reinfection effects are unlinked. Create no new dosing or prevention instructions. This records needed materials; no new research was executed. - Conditions for verification: Material for Parent duration context versus selected clinical follow-up and long-term/other populations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Parent duration context versus selected clinical follow-up and long-term/other populations with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N18 · Can the same Ide report be counted as two trials? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Both questions share the single parent Ide 2014 bibliography; clinical values link to a subclaim note. Do not turn the same report/population into two trials. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Detailed clinical HR table/report attribution, cohorts and unique/independent totals are unverified. - Required materials and conditions: Single bibliography, two subclaim results and report/trial relationships - Materials to obtain first: Detailed clinical HR table/report attribution, cohorts and unique/independent totals are unverified. - Further research: Material needed: Detailed clinical HR table/report attribution, cohorts and unique/independent totals are unverified. This records needed materials; no new research was executed. - Conditions for verification: Material for Single bibliography, two subclaim results and report/trial relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Single bibliography, two subclaim results and report/trial relationships with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N19 · What are public funding, product support and COI? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve the same parent evidence's Public KAKENHI funding wording. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Support, employee authors, COI and analysis/publication roles are unlinked. Public funding alone does not establish independent confirmation or complete support verification. - Required materials and conditions: Distinguishing public funding from products, employees, COI and research roles - Materials to obtain first: Support, employee authors, COI and analysis/publication roles are unlinked. Public funding alone does not establish independent confirmation or complete support verification. - Further research: Material needed: Support, employee authors, COI and analysis/publication roles are unlinked. Public funding alone does not establish independent confirmation or complete support verification. This records needed materials; no new research was executed. - Conditions for verification: Material for Distinguishing public funding from products, employees, COI and research roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Distinguishing public funding from products, employees, COI and research roles with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N20 · Does no adverse-event reporting establish harm verification? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve the parent trial's no-adverse-events-reported statement and Good safety label. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Original collection, arm denominators, missingness/stopping and verification of exactly 0 events are absent. Do not turn clinical null or parent Good into new safety certification. - Required materials and conditions: Harms collection, arm events/denominators, timing, stopping and missingness - Materials to obtain first: Original collection, arm denominators, missingness/stopping and verification of exactly 0 events are absent. Do not turn clinical null or parent Good into new safety certification. - Further research: Material needed: Original collection, arm denominators, missingness/stopping and verification of exactly 0 events are absent. Do not turn clinical null or parent Good into new safety certification. This records needed materials; no new research was executed. - Conditions for verification: Material for Harms collection, arm events/denominators, timing, stopping and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Harms collection, arm events/denominators, timing, stopping and missingness with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N21 · Were long-term and vulnerable-population harms verified? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve the parent's original cautions as historical context without creating new gargling, infection-prevention or treatment instructions. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Harms by other populations, long-term exposure and alternative causes are unlinked. Nonreporting does not establish no harm. - Required materials and conditions: Population, exposure, concurrent factors and long-term harm scope - Materials to obtain first: Harms by other populations, long-term exposure and alternative causes are unlinked. Nonreporting does not establish no harm. - Further research: Material needed: Harms by other populations, long-term exposure and alternative causes are unlinked. Nonreporting does not establish no harm. This records needed materials; no new research was executed. - Conditions for verification: Material for Population, exposure, concurrent factors and long-term harm scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Population, exposure, concurrent factors and long-term harm scope with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N22 · How are original verdicts, both languages, dates and empty histories preserved? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve parent D with 34 points, both languages, axes, 2026-09-07, empty correction/deliberation records and subclaim D with the clinical HR note. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Do not fill absent subclaim score/status/axes from parent values or inherit historical cross-checks as current review/certification. - Required materials and conditions: Parent/subclaim, notes, absent score and date distinctions - Materials to obtain first: Do not fill absent subclaim score/status/axes from parent values or inherit historical cross-checks as current review/certification. - Further research: Material needed: Do not fill absent subclaim score/status/axes from parent values or inherit historical cross-checks as current review/certification. This records needed materials; no new research was executed. - Conditions for verification: Material for Parent/subclaim, notes, absent score and date distinctions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Parent/subclaim, notes, absent score and date distinctions with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N23 · Which materials were actually read? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Production used complete stored summaries, bibliography and the selected note, distinguishing summary reading from unread external materials. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: External papers, registration, protocols/SAPs and support originals are unread and access was not attempted. URLs/historical verification do not become current reading or link checks. - Required materials and conditions: Report/material links and original registration, plan and support access scope - Materials to obtain first: External papers, registration, protocols/SAPs and support originals are unread and access was not attempted. URLs/historical verification do not become current reading or link checks. - Further research: Material needed: External papers, registration, protocols/SAPs and support originals are unread and access was not attempted. URLs/historical verification do not become current reading or link checks. This records needed materials; no new research was executed. - Conditions for verification: Material for Report/material links and original registration, plan and support access scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Report/material links and original registration, plan and support access scope with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP. - Application exceptions: Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ## Evidence and sources ### S01 Ide K, Yamada H, Matsushita K, et al. Effects of Green Tea Gargling on the Prevention of Influenza Infection in High School Students: A Randomized Controlled Study. PLoS One. 2014;9:e96373. PMID: 24836780. PMCID: PMC4023996. DOI: 10.1371/journal.pone.0096373. [PubMed](https://pubmed.ncbi.nlm.nih.gov/24836780/) Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread Findings recorded in the summary: HR 0.77 (0.53 to 1.11), P=.16 was null. Record level: Values from the selected clinically defined subclaim note. Links to original clinical tables, definitions, events, denominators, time origin, interval type/level, adjustment, model, censoring and hierarchy are unverified. Do not substitute the parent bibliography’s laboratory-confirmed results or denominators. Independent replication: Both questions share the same parent Ide bibliography and population; clinical HR is linked to a separate subclaim note. Clinical table/report attribution, cohort details and unique/independent totals are unverified. Do not count endpoints, analyses or sheets as new independent trials or participant totals. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs. | | External paper | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs. | | Protocol | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs. | | Statistical analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs. | | Funding, product-support and COI material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs. | ## Review criteria and methods These are Chamgap's own application conditions, informed by the relevant sections of official methodological guidance. They do not constitute official assessment-tool certification or a new efficacy score. - M03 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03) · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13 · Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M04 [Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04) · §4.5, §4.6.1–4.6.3, MECIR C42 · Distinguish studies from reports and link them; do not omit a study solely because results are unreported. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M08 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08) · §8.1–8.2.3, Table 8.2.a · Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M15 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15) · §15.2.4, §15.3.1–15.3.3 · Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M19 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19) · §19.1.2, §19.2.1–19.2.4 · Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. ## What the statuses mean - Met: A state used when required evidence is confirmed after user review. This production does not declare that review complete. - Partly verified: Some information in the stored summary is linked into the table. External comparison/content review is not complete. - Unverified: The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety. - Review incomplete: User review pending. - Not reported: Not reported within the stored material actually read; not extended to the entire primary paper. - Inaccessible: Means an actual access failure. Access not attempted here is not assigned this state. - Not applicable: Not used as a substitute for an evidence gap. - Conflicting data: Requires an observed disagreement under the same comparison criteria; not automatically judged in this production. - Insufficient evidence for the conditions: Marks a gap in additional material required by the selected conditions; not a new efficacy grade. ## Change history 2026-10-19 · Public page/materials 1.0. Reader pages and materials were prepared from the existing 23 items. No new clinical search, change in verification status or scoring was performed.