{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Green-tea gargling × prevention of clinically defined influenza",
  "language": "en",
  "translation_date": "2026-10-19",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Met": "A state used when required evidence is confirmed after user review. This production does not declare that review complete.",
    "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.",
    "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.",
    "Review incomplete": "User review pending.",
    "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.",
    "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.",
    "Not applicable": "Not used as a substitute for an evidence gap.",
    "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.",
    "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which clinically defined influenza claim is selected?",
      "needed": "Selected question, grade, note and parent laboratory-confirmed context",
      "role": "Required",
      "role_reason": "This condition connects Selected question, grade, note and parent laboratory-confirmed context with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Selected question, grade, note and parent laboratory-confirmed context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Subclaim score, status and axes fields are absent. Do not fill them from parent values or replace this with the laboratory-confirmed endpoint. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "How was clinically defined influenza defined?",
      "needed": "Symptoms, fever/care, case definition and evaluation/adjudication procedures",
      "role": "Required",
      "role_reason": "This condition connects Symptoms, fever/care, case definition and evaluation/adjudication procedures with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Symptoms, fever/care, case definition and evaluation/adjudication procedures must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Exact clinical case criteria, reporting/care, assessors and distinction from other respiratory diseases are unlinked. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "What is the water-control trial context?",
      "needed": "Comparator, arms and added-effect scope linked to the clinical question",
      "role": "Required",
      "role_reason": "This condition connects Comparator, arms and added-effect scope linked to the clinical question with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Comparator, arms and added-effect scope linked to the clinical question must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Arm mapping, comparator conditions and definitions in the original clinical HR table are unlinked. A shared bibliographic link does not become new table verification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Are parent trial participants and clinical denominators the same?",
      "needed": "Eligibility, baseline risk and clinical-outcome denominators",
      "role": "Required",
      "role_reason": "This condition connects Eligibility, baseline risk and clinical-outcome denominators with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Eligibility, baseline risk and clinical-outcome denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Analysis populations, arm denominators, age/eligibility and baseline clinical risk for HR are unlinked. Do not automatically transfer laboratory-confirmed denominators 384/363. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Which gargle formulation and exposure were recorded?",
      "needed": "Products, constituents, concentration, volume, delivery and arm-specific adherence",
      "role": "Required",
      "role_reason": "This condition connects Products, constituents, concentration, volume, delivery and arm-specific adherence with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Products, constituents, concentration, volume, delivery and arm-specific adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Formulation, concentration, actual exposure, delivery adherence and cross-exposure linked to the clinical outcome are unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Were open allocation and clinical-assessment biases verified?",
      "needed": "Allocation, concealment, reporting/adjudication and analysis blinding",
      "role": "Required",
      "role_reason": "This condition connects Allocation, concealment, reporting/adjudication and analysis blinding with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Allocation, concealment, reporting/adjudication and analysis blinding must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Details of blinding in clinical symptom reporting, care selection, event adjudication and analysis are unlinked. Laboratory-endpoint structures do not replace clinical assessment. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Where are HR, interval and P recorded?",
      "needed": "Selected note, estimator, arm direction, interval level and analysis",
      "role": "Required",
      "role_reason": "This condition connects Selected note, estimator, arm direction, interval level and analysis with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Selected note, estimator, arm direction, interval level and analysis must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Arm mapping, adjustment, model and interval type/level are absent from the note. Do not automatically attach the parent laboratory OR's 95% CI label or adjustment. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Were HR time origin, risk sets and censoring verified?",
      "needed": "Follow-up window, events/person-time, time origin, censoring and model assumptions",
      "role": "Required",
      "role_reason": "This condition connects Follow-up window, events/person-time, time origin, censoring and model assumptions with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Follow-up window, events/person-time, time origin, censoring and model assumptions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Clinical HR time origin, censoring/risk sets, recurrent/first events and model assumptions are unlinked. Do not convert HR into cumulative risk or OR. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What are clinical event counts and arm denominators?",
      "needed": "Clinically defined patients/events, recurrence and assessment denominators",
      "role": "Required",
      "role_reason": "This condition connects Clinically defined patients/events, recurrence and assessment denominators with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Clinically defined patients/events, recurrence and assessment denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Clinical events, patients, arm denominators and observation time cannot be replaced by laboratory-confirmed 19/25 or 384/363. Calculate no new events, rates or effects. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Were the clinical analysis population and missingness verified?",
      "needed": "FAS/PP/ITT, symptom/care missingness, exclusions and sensitivity",
      "role": "Required",
      "role_reason": "This condition connects FAS/PP/ITT, symptom/care missingness, exclusions and sensitivity with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for FAS/PP/ITT, symptom/care missingness, exclusions and sensitivity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Clinical HR analysis populations, missingness/exclusions, adherence/PP and sensitivity are unlinked. Do not transfer laboratory-confirmed PP to clinical PP. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Were clinical endpoint hierarchy, multiplicity and registration verified?",
      "needed": "Prespecified primary/secondary designation, changes and testing plan",
      "role": "Required",
      "role_reason": "This condition connects Prespecified primary/secondary designation, changes and testing plan with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Prespecified primary/secondary designation, changes and testing plan must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Clinical hierarchy, multiplicity, changes and original registration/protocol/SAP are unread. Do not promote clinical HR to a new primary endpoint. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Does clinical null mean exact no effect or equivalence?",
      "needed": "Effect direction, interval, prespecified testing and clinical-importance criteria",
      "role": "Required",
      "role_reason": "This condition connects Effect direction, interval, prespecified testing and clinical-importance criteria with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Effect direction, interval, prespecified testing and clinical-importance criteria must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Do not turn this into exact effect 0, equivalence, certain prevention or a new grade F. Clinical-importance criteria and sample-size plans are unlinked. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Are laboratory-confirmed OR/FAS/PP and clinical HR the same result?",
      "needed": "Definitions, units, denominators, times and estimators",
      "role": "Required",
      "role_reason": "This condition connects Definitions, units, denominators, times and estimators with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Definitions, units, denominators, times and estimators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Do not transfer numbers, denominators or analyses between endpoints or count the two results as independent confirmation. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Can the clinical definition extend to other infections, severity or treatment?",
      "needed": "Relationships among clinical cases, laboratory confirmation and other diseases/severity",
      "role": "Required",
      "role_reason": "This condition connects Relationships among clinical cases, laboratory confirmation and other diseases/severity with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Relationships among clinical cases, laboratory confirmation and other diseases/severity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Do not replace the clinical definition with laboratory-confirmed infection, all respiratory diseases, severe disease or treatment effects. Diagnostic correspondence and severe outcomes are unlinked. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Were concurrent exposure, adherence and prevention comparable?",
      "needed": "Existing prevention/vaccination, school exposure, arm-specific delivery and environment",
      "role": "Supplementary",
      "role_reason": "This condition connects Existing prevention/vaccination, school exposure, arm-specific delivery and environment with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Existing prevention/vaccination, school exposure, arm-specific delivery and environment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Concurrent prevention, exposure, adherence, environment and arm mapping for the selected clinical outcome are unlinked. Create no new infection-prevention or treatment guidance. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Can other routes, observations or gargles be combined?",
      "needed": "Selected gargling/water controls versus drinking, capsules and other gargles",
      "role": "Required",
      "role_reason": "This condition connects Selected gargling/water controls versus drinking, capsules and other gargles with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Selected gargling/water controls versus drinking, capsules and other gargles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: These materials were not read now and are not combined as independent replication of the selected clinical HR. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Do effects persist long term or in other populations?",
      "needed": "Parent duration context versus selected clinical follow-up and long-term/other populations",
      "role": "Required",
      "role_reason": "This condition connects Parent duration context versus selected clinical follow-up and long-term/other populations with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Parent duration context versus selected clinical follow-up and long-term/other populations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The exact clinical HR window, long-term/other-age effects, severe disease/hospitalization and reinfection effects are unlinked. Create no new dosing or prevention instructions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Can the same Ide report be counted as two trials?",
      "needed": "Single bibliography, two subclaim results and report/trial relationships",
      "role": "Required",
      "role_reason": "This condition connects Single bibliography, two subclaim results and report/trial relationships with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Single bibliography, two subclaim results and report/trial relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Detailed clinical HR table/report attribution, cohorts and unique/independent totals are unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "What are public funding, product support and COI?",
      "needed": "Distinguishing public funding from products, employees, COI and research roles",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing public funding from products, employees, COI and research roles with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Distinguishing public funding from products, employees, COI and research roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Support, employee authors, COI and analysis/publication roles are unlinked. Public funding alone does not establish independent confirmation or complete support verification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Does no adverse-event reporting establish harm verification?",
      "needed": "Harms collection, arm events/denominators, timing, stopping and missingness",
      "role": "Supplementary",
      "role_reason": "This condition connects Harms collection, arm events/denominators, timing, stopping and missingness with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Harms collection, arm events/denominators, timing, stopping and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original collection, arm denominators, missingness/stopping and verification of exactly 0 events are absent. Do not turn clinical null or parent Good into new safety certification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Were long-term and vulnerable-population harms verified?",
      "needed": "Population, exposure, concurrent factors and long-term harm scope",
      "role": "Supplementary",
      "role_reason": "This condition connects Population, exposure, concurrent factors and long-term harm scope with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Population, exposure, concurrent factors and long-term harm scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Harms by other populations, long-term exposure and alternative causes are unlinked. Nonreporting does not establish no harm. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "How are original verdicts, both languages, dates and empty histories preserved?",
      "needed": "Parent/subclaim, notes, absent score and date distinctions",
      "role": "Required",
      "role_reason": "This condition connects Parent/subclaim, notes, absent score and date distinctions with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Parent/subclaim, notes, absent score and date distinctions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Do not fill absent subclaim score/status/axes from parent values or inherit historical cross-checks as current review/certification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Which materials were actually read?",
      "needed": "Report/material links and original registration, plan and support access scope",
      "role": "Required",
      "role_reason": "This condition connects Report/material links and original registration, plan and support access scope with the definitions, events, denominators, time origin, censoring, analysis, hierarchy and harms of clinically defined influenza HR, distinguishing parent laboratory-confirmed OR/FAS/PP.",
      "application_exception": "Preserve selected D and the clinical HR null note. Distinguish absent subclaim score/status/axes from parent D with 34 points and laboratory-confirmed context. Do not transfer laboratory events, denominators, OR, PP, the 95% CI label or adjustment to clinical HR. Create no new events, rates, effects, intervals, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Report/material links and original registration, plan and support access scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: External papers, registration, protocols/SAPs and support originals are unread and access was not attempted. URLs/historical verification do not become current reading or link checks. This records needed materials; no new research was executed."
    }
  ]
}