Green-tea gargling × added laboratory-confirmed influenza prevention over water

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionWhich added laboratory-confirmed prevention claim is selected?Required	The selection is added prevention of laboratory-confirmed influenza over water gargling. Preserve original grade D and the note that the OR 0.69 interval included 1. Parent D with 34 points is separate context. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Selected claim, grade and note versus the parent verdict	Material needed: The subclaim has no score, status or axes fields. Do not fill them with parent values. This records needed materials; no new research was executed.
2	Partly verified	Full text not readStored summary read	N02 · Evidence conditionWhich Japanese high-school students participated?Required	The original trial records 757 randomized Japanese high-school students and 747 in FAS. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Age, recruitment, schools, exposure, baseline risk and eligibility/exclusions	Material needed: Exact age range, school/recruitment conditions, baseline infection risk, eligibility/exclusions and baseline characteristics are unverified. This records needed materials; no new research was executed.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionWhat green-tea gargle was studied?Required	Green-tea gargling 3 times daily for 90 days is original study exposure. Create no new gargling, infection-prevention or treatment instructions. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Product, constituents, concentration, volume, quality and actual delivery	Material needed: Products, catechin/constituents, concentration, volume, actual delivery and solution-quality details are unverified. This records needed materials; no new research was executed.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionWhat are the water control and added effect?Required	Preserve the original green-tea/tap-water comparison and control water gargling 3 times daily. This was not a comparison against no gargling. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Gargling in both arms, control composition, procedures, contact and adherence	Material needed: Matching solution procedures, volumes, delivery/contact and adherence records are unverified. This records needed materials; no new research was executed.
5	Partly verified	Full text not readStored summary read	N05 · Evidence conditionWere allocation and evaluation roles in the open trial verified?Required	Preserve Ide's original open randomized design. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Random sequences, allocation concealment and tester/adjudicator/analyst blinding	Material needed: Allocation concealment, school/arm structures and tester/event-adjudicator/analyst blinding are unverified. An open design alone does not establish absent blinding for every role. This records needed materials; no new research was executed.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionAre randomization, FAS and testing denominators the same?Required	Preserve 757 randomized, 747 FAS and laboratory-confirmed results of 19/384 versus 25/363. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Arm allocation, FAS definitions, exclusions, event assessment and missingness	Material needed: Arm randomization counts, exclusion reasons, FAS definitions and missing test data are unverified. Calculate no new attrition counts, rates or denominators. This records needed materials; no new research was executed.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionHow was laboratory-confirmed influenza defined?Required	The key endpoint is laboratory-confirmed influenza over 90 days. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Tests, diagnostic thresholds, symptoms and collection/confirmation timing	Material needed: Exact test methods, thresholds, timing, collection/confirmation, symptom criteria and handling of untested cases are unverified. This records needed materials; no new research was executed.
8	Partly verified	Full text not readStored summary read	N08 · Evidence conditionHow are events and arm denominators assigned?Required	The original record assigns laboratory-confirmed results to green tea 19/384 and water 25/363. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Arm labels, event/person units, repeated/first events and test denominators	Material needed: Repeated infections, first events and test-denominator definitions are unverified. Calculate no new risks, event rates, risk ratios or risk differences. This records needed materials; no new research was executed.
9	Partly verified	Full text not readStored summary read	N09 · Evidence conditionWhat are the adjusted OR, interval and P?Required	Preserve adjusted OR 0.69 (95% CI 0.37 to 1.28), P=.24. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Estimator, adjustment variables, model, denominators and interval/test relationships	Material needed: Adjustment variables, models, standard errors and original analysis outputs are unverified. Do not turn OR into a risk ratio or HR or create new estimates. This records needed materials; no new research was executed.
10	Partly verified	Full text not readStored summary read	N10 · Evidence conditionHow are PP and FAS results distinguished?Required	The original text records PP OR 0.86 (0.44 to 1.69), P=.66 and null FAS/PP results. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	PP definitions, denominators, adherence, missingness, interval level and model	Material needed: PP arm denominators, adherence criteria, missing-data handling, interval level and models are unverified. Do not turn PP values into FAS or clinically defined HR. This records needed materials; no new research was executed.
11	Partly verified	Full text not readStored summary read	N11 · Evidence conditionDoes a registration identifier verify prospective endpoints?Required	The original text describes failure of the central direct comparison, and original evidence records NCT01225770. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Registration timing, endpoint hierarchy/changes, protocol and SAP	Material needed: Registration timing, endpoint changes, protocols/SAPs and planned models are unread. Identifiers and historical descriptions do not establish a completed current prospective-status review. This records needed materials; no new research was executed.
12	Unverified	Full text not readStored summary read	N12 · Evidence conditionWere missingness, adherence and testing completeness verified?Required	The original text distinguishes FAS and PP results but provides no detailed policies. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Suspected/untested infections, missed delivery and ITT/FAS/PP policies	Material needed: Missing tests, exclusions, adherence, observation completeness and sensitivity analyses are unverified. Do not fill in FAS as analysis of all randomized participants. This records needed materials; no new research was executed.
13	Unverified	Full text not readStored summary read	N13 · Evidence conditionWere observation windows, exposure and concurrent prevention matched?Supplementary	Preserve the original 90-day window and water-controlled scope. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Start/end, season, school environment, vaccination and shared exposure	Material needed: Season, exposure, school environment and arm matching of concurrent prevention/vaccination or other interventions are unverified. Provide no new prevention guidance. This records needed materials; no new research was executed.
14	Partly verified	Full text not readStored summary read	N14 · Evidence conditionAre clinically defined HR and laboratory-confirmed OR the same?Required	Distinguish the separate subclaim note's clinically defined HR 0.77 (0.53 to 1.11), P=.16 from laboratory-confirmed OR/PP. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Diagnostic definitions, events/denominators, timing, models, hierarchy and estimators	Material needed: Do not substitute HR values/intervals for laboratory-confirmed OR or identical denominators. Original links for definitions, analyses, hierarchy, time origins and interval types are unverified. This records needed materials; no new research was executed.
15	Partly verified	Full text not readStored summary read	N15 · Evidence conditionHow are wide intervals and null results interpreted?Required	The interval includes 1; the original text records possible benefit and some harm alongside no proof of complete null effects or equivalence. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Planned comparisons, possible effect ranges and clinical importance	Material needed: Clinical importance thresholds and sample planning are unverified. Create no new effects, CIs, absolute effects, equivalence, grade F or certain prevention. This records needed materials; no new research was executed.
16	Partly verified	Full text not readStored summary read	N16 · Evidence conditionCan drinking, capsules or observations support this effect?Required	The original text did not count green-tea drinking, capsules or nursing-home observations as replication of the gargling randomized trial. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Exposure routes, formulations, populations, designs and separate questions	Material needed: Do not transfer numbers from other routes, populations or designs into the selected added effect. Those materials were not newly read this run. This records needed materials; no new research was executed.
17	Partly verified	Full text not readStored summary read	N17 · Evidence conditionIs another gargling verdict the same intervention?Required	The original text records a different intervention in povidone-iodine/water gargling verdict 720. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Povidone-iodine/water versus the selected green-tea/water comparison	Material needed: Do not newly read 720 or combine it as replication in this sheet. Do not use other-gargle effects to strengthen this result. This records needed materials; no new research was executed.
18	Unverified	Full text not readStored summary read	N18 · Evidence conditionDoes this answer other populations, long-term, severe-disease or treatment effects?Required	The selection is a 90-day water-controlled added effect in high-school students. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Age, season, duration, severe disease/hospitalization and treatment boundaries	Material needed: Other ages, seasons, lasting effects, severe disease/hospitalization and treatment effects are unverified. Do not transfer laboratory-confirmed prevention results into treatment effects. This records needed materials; no new research was executed.
19	Partly verified	Full text not readStored summary read	N19 · Evidence conditionCan one report and two questions count as independent trials?Required	Laboratory-confirmed and clinically defined questions share the same Ide report. Do not count two endpoints or sheets as new trials or populations. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Report, population, endpoint and sheet relationships and unique totals	Material needed: Independent confirmation under the same conditions is unverified. Do not establish unique-trial, participant or independent-replication totals. This records needed materials; no new research was executed.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionWhat were public funding, support and author roles?Required	Original evidence records public KAKENHI funding, described as a strength in the parent text. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Financial/product/material support, employee authors, COI and analysis/publication roles	Material needed: Product/material support, employee authors, COI and design/analysis/publication roles are unverified. Funding information alone does not verify overall independence. This records needed materials; no new research was executed.
21	Partly verified	Full text not readStored summary read	N21 · Evidence conditionDoes no reported adverse event establish safety?Supplementary	Preserve the wording that no adverse events were reported in the trial and parent Good safety status. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original harm collection, arm events, denominators, missingness and stopping	Material needed: Collection procedures, arm denominators, missingness/stopping and exact event counts are unverified. No reports do not become new safety certification or verified event counts. This records needed materials; no new research was executed.
22	Unverified	Full text not readStored summary read	N22 · Evidence conditionIs this safe across ages, abilities and long-term exposures?Supplementary	Preserve original parent safety text and create no new gargling, infection-prevention or treatment instructions. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Vulnerable populations, exposures, concurrent factors, alternative causes and follow-up	Material needed: Other ages, gargling abilities, exposures, long-term harms and alternative-cause data are unverified. Do not extend parent Good status into safety for everyone. This records needed materials; no new research was executed.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionHow are verdicts, both languages and dates preserved?Required	Preserve parent D with 34 points, original bilingual texts, axes, 2026-09-07, empty correction/deliberation records and subclaim D/note with absent score/status/axes. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Parent/subclaim original values, axes, empty histories and evidence date	Material needed: Historical cross-checks and strengths of direct trials do not become current review, satisfied conditions or subclaim scores. Distinguish production from evidence dates. This records needed materials; no new research was executed.
24	Partly verified	Full text not readStored summary read	N24 · Evidence conditionWhich materials were actually read?Required	Production used complete stored summaries and bibliography. Distinguish summary reading, unread external materials and source links. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Stored summaries, bibliography, external papers, registration, plans and support	Material needed: External papers, registration, protocols/SAPs and support originals are unread and access was not attempted. URLs/historical verification do not become current reading or link checks. This records needed materials; no new research was executed.

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24 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-09-07
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: The trial randomized 757 Japanese high-school students and analyzed 747 in FAS. Original laboratory-confirmed denominators are 384 for green tea and 363 for water. Age range, schools/recruitment, baseline risk, eligibility/exclusions, arm allocation and analysis exclusions are unverified. Do not directly extend this to other ages or institutional populations.
Ingredient, formulation and route: An open randomized comparison of green-tea versus tap-water gargling. Products, catechin/constituents, concentration, volume, solution quality and actual delivery are unverified. Do not combine drinking, capsules, observational studies or other gargles as the same intervention or independent replication.
Dose: Original study exposure is 3 times daily for 90 days; water controls also gargled. Constituent amounts, solutions, volume, actual exposure, adherence and stopping are unverified. Calculate no total exposure and create no personal gargling, infection-prevention or treatment instructions.
Comparator: Tap-water gargling is the control; the question concerns added green-tea-constituent effects on top of gargling in both arms. The original text records control gargling 3 times daily. This is not a no-gargling comparator; matching procedures, volume, contact, delivery and adherence are unverified.
Measured outcome: The selection is added prevention of laboratory-confirmed influenza. Preserve green tea 19/384 versus water 25/363, adjusted OR 0.69 (95% CI 0.37 to 1.28), P=.24. PP OR 0.86 (0.44 to 1.69), P=.66 is a separate analysis with unverified denominators, interval level and criteria. Clinically defined HR is a separate subclaim record.
Duration: The original trial spans 90 days; exact start/end, season, exposure, concurrent prevention, testing times and long-term follow-up are unverified. Do not extend this window into other seasons/populations, lasting effects, severe disease/hospitalization or treatment effects.
Questions outside this scope: Turning added effects over water gargling into green-tea gargling versus no gargling; Interchanging FAS/PP OR with clinically defined HR, intervals, denominators or hierarchy; Turning wide intervals or null results into exact effect 0, equivalence, a new grade F or certain prevention; Counting drinking, capsules, nursing-home observations, other gargles or verdict 720 as the same intervention or independent replication; Transferring laboratory-confirmed results into clinically defined, severe-disease, treatment or other-population/period effects; Using public funding, parent D with 34 points, Good safety or historical verification as subclaim scores or new independence/safety certification; Creating new event rates, effects, CIs, totals, gargling procedures, infection-prevention or treatment instructions

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

S01 · Ide K, Yamada H, Matsushita K, et al. Effects of Green Tea Gargling on the Prevention of Influenza Infection in High School Students: A Randomized Controlled Study. PLoS One. 2014;9:e96373. PMID: 24836780. PMCID: PMC4023996. DOI: 10.1371/journal.pone.0096373.

PubMed

Material type: Open randomized green-tea versus tap-water trial
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary: 19/384 vs 25/363; OR 0.69 (0.37 to 1.28), P=.24
Record level: Laboratory-confirmed results from 757 randomized, 747 FAS participants over 90 days of green-tea versus water gargling. Preserve green tea 19/384, water 25/363 and adjusted OR 0.69 (95% CI 0.37 to 1.28), P=.24. Denominators and interval level for PP OR 0.86 (0.44 to 1.69), P=.66 are unverified. Distinguish clinically defined HR and no-gargling comparisons; calculate no new event rates or effects.
Study overlap and independent replication: Laboratory-confirmed and clinically defined questions share the same Ide report and population. Do not count different endpoints, analysis populations or sheets as new independent trials or participant totals. Independent confirmation under the same conditions and unique-trial/participant totals are unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs.
External paper	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs.
Protocol	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs.
Statistical analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs.
Funding, product-support and COI material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 24836780, PMCID PMC4023996 and DOI 10.1371/journal.pone.0096373. Original evidence registration wording is NCT01225770; a separate registration annotation is unrecorded for this case. Identifiers/PMCID do not establish registration/full-text reading or prospective verification; infer no new URLs.

Report counts versus independent study counts

Laboratory-confirmed and clinically defined questions share the same Ide report and population. Do not count different endpoints, analysis populations or sheets as new independent trials or participant totals. Independent confirmation under the same conditions and unique-trial/participant totals are unverified.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which added laboratory-confirmed prevention claim is selected?

Required materials and conditions: Selected claim, grade and note versus the parent verdict
Conditions for verification: Material for Selected claim, grade and note versus the parent verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Selected claim, grade and note versus the parent verdict with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N02 · Which Japanese high-school students participated?

Required materials and conditions: Age, recruitment, schools, exposure, baseline risk and eligibility/exclusions
Conditions for verification: Material for Age, recruitment, schools, exposure, baseline risk and eligibility/exclusions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Age, recruitment, schools, exposure, baseline risk and eligibility/exclusions with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N03 · What green-tea gargle was studied?

Required materials and conditions: Product, constituents, concentration, volume, quality and actual delivery
Conditions for verification: Material for Product, constituents, concentration, volume, quality and actual delivery must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Product, constituents, concentration, volume, quality and actual delivery with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N04 · What are the water control and added effect?

Required materials and conditions: Gargling in both arms, control composition, procedures, contact and adherence
Conditions for verification: Material for Gargling in both arms, control composition, procedures, contact and adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Gargling in both arms, control composition, procedures, contact and adherence with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N05 · Were allocation and evaluation roles in the open trial verified?

Required materials and conditions: Random sequences, allocation concealment and tester/adjudicator/analyst blinding
Conditions for verification: Material for Random sequences, allocation concealment and tester/adjudicator/analyst blinding must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Random sequences, allocation concealment and tester/adjudicator/analyst blinding with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N06 · Are randomization, FAS and testing denominators the same?

Required materials and conditions: Arm allocation, FAS definitions, exclusions, event assessment and missingness
Conditions for verification: Material for Arm allocation, FAS definitions, exclusions, event assessment and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Arm allocation, FAS definitions, exclusions, event assessment and missingness with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N07 · How was laboratory-confirmed influenza defined?

Required materials and conditions: Tests, diagnostic thresholds, symptoms and collection/confirmation timing
Conditions for verification: Material for Tests, diagnostic thresholds, symptoms and collection/confirmation timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Tests, diagnostic thresholds, symptoms and collection/confirmation timing with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N08 · How are events and arm denominators assigned?

Required materials and conditions: Arm labels, event/person units, repeated/first events and test denominators
Conditions for verification: Material for Arm labels, event/person units, repeated/first events and test denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Arm labels, event/person units, repeated/first events and test denominators with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N09 · What are the adjusted OR, interval and P?

Required materials and conditions: Estimator, adjustment variables, model, denominators and interval/test relationships
Conditions for verification: Material for Estimator, adjustment variables, model, denominators and interval/test relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Estimator, adjustment variables, model, denominators and interval/test relationships with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N10 · How are PP and FAS results distinguished?

Required materials and conditions: PP definitions, denominators, adherence, missingness, interval level and model
Conditions for verification: Material for PP definitions, denominators, adherence, missingness, interval level and model must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects PP definitions, denominators, adherence, missingness, interval level and model with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N11 · Does a registration identifier verify prospective endpoints?

Required materials and conditions: Registration timing, endpoint hierarchy/changes, protocol and SAP
Conditions for verification: Material for Registration timing, endpoint hierarchy/changes, protocol and SAP must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Registration timing, endpoint hierarchy/changes, protocol and SAP with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N12 · Were missingness, adherence and testing completeness verified?

Required materials and conditions: Suspected/untested infections, missed delivery and ITT/FAS/PP policies
Conditions for verification: Material for Suspected/untested infections, missed delivery and ITT/FAS/PP policies must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Suspected/untested infections, missed delivery and ITT/FAS/PP policies with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N13 · Were observation windows, exposure and concurrent prevention matched?

Required materials and conditions: Start/end, season, school environment, vaccination and shared exposure
Conditions for verification: Material for Start/end, season, school environment, vaccination and shared exposure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Start/end, season, school environment, vaccination and shared exposure with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N14 · Are clinically defined HR and laboratory-confirmed OR the same?

Required materials and conditions: Diagnostic definitions, events/denominators, timing, models, hierarchy and estimators
Conditions for verification: Material for Diagnostic definitions, events/denominators, timing, models, hierarchy and estimators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Diagnostic definitions, events/denominators, timing, models, hierarchy and estimators with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N15 · How are wide intervals and null results interpreted?

Required materials and conditions: Planned comparisons, possible effect ranges and clinical importance
Conditions for verification: Material for Planned comparisons, possible effect ranges and clinical importance must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Planned comparisons, possible effect ranges and clinical importance with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N16 · Can drinking, capsules or observations support this effect?

Required materials and conditions: Exposure routes, formulations, populations, designs and separate questions
Conditions for verification: Material for Exposure routes, formulations, populations, designs and separate questions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Exposure routes, formulations, populations, designs and separate questions with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N17 · Is another gargling verdict the same intervention?

Required materials and conditions: Povidone-iodine/water versus the selected green-tea/water comparison
Conditions for verification: Material for Povidone-iodine/water versus the selected green-tea/water comparison must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Povidone-iodine/water versus the selected green-tea/water comparison with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N18 · Does this answer other populations, long-term, severe-disease or treatment effects?

Required materials and conditions: Age, season, duration, severe disease/hospitalization and treatment boundaries
Conditions for verification: Material for Age, season, duration, severe disease/hospitalization and treatment boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Age, season, duration, severe disease/hospitalization and treatment boundaries with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N19 · Can one report and two questions count as independent trials?

Required materials and conditions: Report, population, endpoint and sheet relationships and unique totals
Conditions for verification: Material for Report, population, endpoint and sheet relationships and unique totals must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Report, population, endpoint and sheet relationships and unique totals with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N20 · What were public funding, support and author roles?

Required materials and conditions: Financial/product/material support, employee authors, COI and analysis/publication roles
Conditions for verification: Material for Financial/product/material support, employee authors, COI and analysis/publication roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Financial/product/material support, employee authors, COI and analysis/publication roles with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N21 · Does no reported adverse event establish safety?

Required materials and conditions: Original harm collection, arm events, denominators, missingness and stopping
Conditions for verification: Material for Original harm collection, arm events, denominators, missingness and stopping must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Original harm collection, arm events, denominators, missingness and stopping with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N22 · Is this safe across ages, abilities and long-term exposures?

Required materials and conditions: Vulnerable populations, exposures, concurrent factors, alternative causes and follow-up
Conditions for verification: Material for Vulnerable populations, exposures, concurrent factors, alternative causes and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Vulnerable populations, exposures, concurrent factors, alternative causes and follow-up with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N23 · How are verdicts, both languages and dates preserved?

Required materials and conditions: Parent/subclaim original values, axes, empty histories and evidence date
Conditions for verification: Material for Parent/subclaim original values, axes, empty histories and evidence date must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Parent/subclaim original values, axes, empty histories and evidence date with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N24 · Which materials were actually read?

Required materials and conditions: Stored summaries, bibliography, external papers, registration, plans and support
Conditions for verification: Material for Stored summaries, bibliography, external papers, registration, plans and support must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Why this condition is needed: This condition connects Stored summaries, bibliography, external papers, registration, plans and support with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

What the statuses mean

Met: A state used when required evidence is confirmed after user review. This production does not declare that review complete.
Partly verified: Some information in the stored summary is linked into the table. External comparison/content review is not complete.
Unverified: The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.
Review incomplete: User review pending.
Not reported: Not reported within the stored material actually read; not extended to the entire primary paper.
Inaccessible: Means an actual access failure. Access not attempted here is not assigned this state.
Not applicable: Not used as a substitute for an evidence gap.
Conflicting data: Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.
Insufficient evidence for the conditions: Marks a gap in additional material required by the selected conditions; not a new efficacy grade.

Change history

2026-10-19 · Public page/material version 1.0

Public pages and materials were prepared from the existing 24 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-09-07) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which added laboratory-confirmed prevention claim is selected?

Current findings: The selection is added prevention of laboratory-confirmed influenza over water gargling. Preserve original grade D and the note that the OR 0.69 interval included 1. Parent D with 34 points is separate context.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: The subclaim has no score, status or axes fields. Do not fill them with parent values.
Required materials and conditions: Selected claim, grade and note versus the parent verdict
Materials to obtain first: The subclaim has no score, status or axes fields. Do not fill them with parent values.
Further research: Material needed: The subclaim has no score, status or axes fields. Do not fill them with parent values. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Selected claim, grade and note versus the parent verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Selected claim, grade and note versus the parent verdict with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N02 · Which Japanese high-school students participated?

Current findings: The original trial records 757 randomized Japanese high-school students and 747 in FAS.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Exact age range, school/recruitment conditions, baseline infection risk, eligibility/exclusions and baseline characteristics are unverified.
Required materials and conditions: Age, recruitment, schools, exposure, baseline risk and eligibility/exclusions
Materials to obtain first: Exact age range, school/recruitment conditions, baseline infection risk, eligibility/exclusions and baseline characteristics are unverified.
Further research: Material needed: Exact age range, school/recruitment conditions, baseline infection risk, eligibility/exclusions and baseline characteristics are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Age, recruitment, schools, exposure, baseline risk and eligibility/exclusions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Age, recruitment, schools, exposure, baseline risk and eligibility/exclusions with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N03 · What green-tea gargle was studied?

Current findings: Green-tea gargling 3 times daily for 90 days is original study exposure. Create no new gargling, infection-prevention or treatment instructions.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Products, catechin/constituents, concentration, volume, actual delivery and solution-quality details are unverified.
Required materials and conditions: Product, constituents, concentration, volume, quality and actual delivery
Materials to obtain first: Products, catechin/constituents, concentration, volume, actual delivery and solution-quality details are unverified.
Further research: Material needed: Products, catechin/constituents, concentration, volume, actual delivery and solution-quality details are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Product, constituents, concentration, volume, quality and actual delivery must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Product, constituents, concentration, volume, quality and actual delivery with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N04 · What are the water control and added effect?

Current findings: Preserve the original green-tea/tap-water comparison and control water gargling 3 times daily. This was not a comparison against no gargling.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Matching solution procedures, volumes, delivery/contact and adherence records are unverified.
Required materials and conditions: Gargling in both arms, control composition, procedures, contact and adherence
Materials to obtain first: Matching solution procedures, volumes, delivery/contact and adherence records are unverified.
Further research: Material needed: Matching solution procedures, volumes, delivery/contact and adherence records are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Gargling in both arms, control composition, procedures, contact and adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Gargling in both arms, control composition, procedures, contact and adherence with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N05 · Were allocation and evaluation roles in the open trial verified?

Current findings: Preserve Ide's original open randomized design.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Allocation concealment, school/arm structures and tester/event-adjudicator/analyst blinding are unverified. An open design alone does not establish absent blinding for every role.
Required materials and conditions: Random sequences, allocation concealment and tester/adjudicator/analyst blinding
Materials to obtain first: Allocation concealment, school/arm structures and tester/event-adjudicator/analyst blinding are unverified. An open design alone does not establish absent blinding for every role.
Further research: Material needed: Allocation concealment, school/arm structures and tester/event-adjudicator/analyst blinding are unverified. An open design alone does not establish absent blinding for every role. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Random sequences, allocation concealment and tester/adjudicator/analyst blinding must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Random sequences, allocation concealment and tester/adjudicator/analyst blinding with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N06 · Are randomization, FAS and testing denominators the same?

Current findings: Preserve 757 randomized, 747 FAS and laboratory-confirmed results of 19/384 versus 25/363.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm randomization counts, exclusion reasons, FAS definitions and missing test data are unverified. Calculate no new attrition counts, rates or denominators.
Required materials and conditions: Arm allocation, FAS definitions, exclusions, event assessment and missingness
Materials to obtain first: Arm randomization counts, exclusion reasons, FAS definitions and missing test data are unverified. Calculate no new attrition counts, rates or denominators.
Further research: Material needed: Arm randomization counts, exclusion reasons, FAS definitions and missing test data are unverified. Calculate no new attrition counts, rates or denominators. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Arm allocation, FAS definitions, exclusions, event assessment and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Arm allocation, FAS definitions, exclusions, event assessment and missingness with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N07 · How was laboratory-confirmed influenza defined?

Current findings: The key endpoint is laboratory-confirmed influenza over 90 days.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Exact test methods, thresholds, timing, collection/confirmation, symptom criteria and handling of untested cases are unverified.
Required materials and conditions: Tests, diagnostic thresholds, symptoms and collection/confirmation timing
Materials to obtain first: Exact test methods, thresholds, timing, collection/confirmation, symptom criteria and handling of untested cases are unverified.
Further research: Material needed: Exact test methods, thresholds, timing, collection/confirmation, symptom criteria and handling of untested cases are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Tests, diagnostic thresholds, symptoms and collection/confirmation timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Tests, diagnostic thresholds, symptoms and collection/confirmation timing with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N08 · How are events and arm denominators assigned?

Current findings: The original record assigns laboratory-confirmed results to green tea 19/384 and water 25/363.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Repeated infections, first events and test-denominator definitions are unverified. Calculate no new risks, event rates, risk ratios or risk differences.
Required materials and conditions: Arm labels, event/person units, repeated/first events and test denominators
Materials to obtain first: Repeated infections, first events and test-denominator definitions are unverified. Calculate no new risks, event rates, risk ratios or risk differences.
Further research: Material needed: Repeated infections, first events and test-denominator definitions are unverified. Calculate no new risks, event rates, risk ratios or risk differences. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Arm labels, event/person units, repeated/first events and test denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Arm labels, event/person units, repeated/first events and test denominators with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N09 · What are the adjusted OR, interval and P?

Current findings: Preserve adjusted OR 0.69 (95% CI 0.37 to 1.28), P=.24.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Adjustment variables, models, standard errors and original analysis outputs are unverified. Do not turn OR into a risk ratio or HR or create new estimates.
Required materials and conditions: Estimator, adjustment variables, model, denominators and interval/test relationships
Materials to obtain first: Adjustment variables, models, standard errors and original analysis outputs are unverified. Do not turn OR into a risk ratio or HR or create new estimates.
Further research: Material needed: Adjustment variables, models, standard errors and original analysis outputs are unverified. Do not turn OR into a risk ratio or HR or create new estimates. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Estimator, adjustment variables, model, denominators and interval/test relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Estimator, adjustment variables, model, denominators and interval/test relationships with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N10 · How are PP and FAS results distinguished?

Current findings: The original text records PP OR 0.86 (0.44 to 1.69), P=.66 and null FAS/PP results.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: PP arm denominators, adherence criteria, missing-data handling, interval level and models are unverified. Do not turn PP values into FAS or clinically defined HR.
Required materials and conditions: PP definitions, denominators, adherence, missingness, interval level and model
Materials to obtain first: PP arm denominators, adherence criteria, missing-data handling, interval level and models are unverified. Do not turn PP values into FAS or clinically defined HR.
Further research: Material needed: PP arm denominators, adherence criteria, missing-data handling, interval level and models are unverified. Do not turn PP values into FAS or clinically defined HR. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for PP definitions, denominators, adherence, missingness, interval level and model must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects PP definitions, denominators, adherence, missingness, interval level and model with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N11 · Does a registration identifier verify prospective endpoints?

Current findings: The original text describes failure of the central direct comparison, and original evidence records NCT01225770.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Registration timing, endpoint changes, protocols/SAPs and planned models are unread. Identifiers and historical descriptions do not establish a completed current prospective-status review.
Required materials and conditions: Registration timing, endpoint hierarchy/changes, protocol and SAP
Materials to obtain first: Registration timing, endpoint changes, protocols/SAPs and planned models are unread. Identifiers and historical descriptions do not establish a completed current prospective-status review.
Further research: Material needed: Registration timing, endpoint changes, protocols/SAPs and planned models are unread. Identifiers and historical descriptions do not establish a completed current prospective-status review. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Registration timing, endpoint hierarchy/changes, protocol and SAP must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Registration timing, endpoint hierarchy/changes, protocol and SAP with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N12 · Were missingness, adherence and testing completeness verified?

Current findings: The original text distinguishes FAS and PP results but provides no detailed policies.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Missing tests, exclusions, adherence, observation completeness and sensitivity analyses are unverified. Do not fill in FAS as analysis of all randomized participants.
Required materials and conditions: Suspected/untested infections, missed delivery and ITT/FAS/PP policies
Materials to obtain first: Missing tests, exclusions, adherence, observation completeness and sensitivity analyses are unverified. Do not fill in FAS as analysis of all randomized participants.
Further research: Material needed: Missing tests, exclusions, adherence, observation completeness and sensitivity analyses are unverified. Do not fill in FAS as analysis of all randomized participants. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Suspected/untested infections, missed delivery and ITT/FAS/PP policies must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Suspected/untested infections, missed delivery and ITT/FAS/PP policies with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N13 · Were observation windows, exposure and concurrent prevention matched?

Current findings: Preserve the original 90-day window and water-controlled scope.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Season, exposure, school environment and arm matching of concurrent prevention/vaccination or other interventions are unverified. Provide no new prevention guidance.
Required materials and conditions: Start/end, season, school environment, vaccination and shared exposure
Materials to obtain first: Season, exposure, school environment and arm matching of concurrent prevention/vaccination or other interventions are unverified. Provide no new prevention guidance.
Further research: Material needed: Season, exposure, school environment and arm matching of concurrent prevention/vaccination or other interventions are unverified. Provide no new prevention guidance. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Start/end, season, school environment, vaccination and shared exposure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Start/end, season, school environment, vaccination and shared exposure with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

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N14 · Are clinically defined HR and laboratory-confirmed OR the same?

Current findings: Distinguish the separate subclaim note's clinically defined HR 0.77 (0.53 to 1.11), P=.16 from laboratory-confirmed OR/PP.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Do not substitute HR values/intervals for laboratory-confirmed OR or identical denominators. Original links for definitions, analyses, hierarchy, time origins and interval types are unverified.
Required materials and conditions: Diagnostic definitions, events/denominators, timing, models, hierarchy and estimators
Materials to obtain first: Do not substitute HR values/intervals for laboratory-confirmed OR or identical denominators. Original links for definitions, analyses, hierarchy, time origins and interval types are unverified.
Further research: Material needed: Do not substitute HR values/intervals for laboratory-confirmed OR or identical denominators. Original links for definitions, analyses, hierarchy, time origins and interval types are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Diagnostic definitions, events/denominators, timing, models, hierarchy and estimators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Diagnostic definitions, events/denominators, timing, models, hierarchy and estimators with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

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N15 · How are wide intervals and null results interpreted?

Current findings: The interval includes 1; the original text records possible benefit and some harm alongside no proof of complete null effects or equivalence.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Clinical importance thresholds and sample planning are unverified. Create no new effects, CIs, absolute effects, equivalence, grade F or certain prevention.
Required materials and conditions: Planned comparisons, possible effect ranges and clinical importance
Materials to obtain first: Clinical importance thresholds and sample planning are unverified. Create no new effects, CIs, absolute effects, equivalence, grade F or certain prevention.
Further research: Material needed: Clinical importance thresholds and sample planning are unverified. Create no new effects, CIs, absolute effects, equivalence, grade F or certain prevention. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Planned comparisons, possible effect ranges and clinical importance must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Planned comparisons, possible effect ranges and clinical importance with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

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N16 · Can drinking, capsules or observations support this effect?

Current findings: The original text did not count green-tea drinking, capsules or nursing-home observations as replication of the gargling randomized trial.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Do not transfer numbers from other routes, populations or designs into the selected added effect. Those materials were not newly read this run.
Required materials and conditions: Exposure routes, formulations, populations, designs and separate questions
Materials to obtain first: Do not transfer numbers from other routes, populations or designs into the selected added effect. Those materials were not newly read this run.
Further research: Material needed: Do not transfer numbers from other routes, populations or designs into the selected added effect. Those materials were not newly read this run. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Exposure routes, formulations, populations, designs and separate questions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Exposure routes, formulations, populations, designs and separate questions with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

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N17 · Is another gargling verdict the same intervention?

Current findings: The original text records a different intervention in povidone-iodine/water gargling verdict 720.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Do not newly read 720 or combine it as replication in this sheet. Do not use other-gargle effects to strengthen this result.
Required materials and conditions: Povidone-iodine/water versus the selected green-tea/water comparison
Materials to obtain first: Do not newly read 720 or combine it as replication in this sheet. Do not use other-gargle effects to strengthen this result.
Further research: Material needed: Do not newly read 720 or combine it as replication in this sheet. Do not use other-gargle effects to strengthen this result. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Povidone-iodine/water versus the selected green-tea/water comparison must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Povidone-iodine/water versus the selected green-tea/water comparison with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

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N18 · Does this answer other populations, long-term, severe-disease or treatment effects?

Current findings: The selection is a 90-day water-controlled added effect in high-school students.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Other ages, seasons, lasting effects, severe disease/hospitalization and treatment effects are unverified. Do not transfer laboratory-confirmed prevention results into treatment effects.
Required materials and conditions: Age, season, duration, severe disease/hospitalization and treatment boundaries
Materials to obtain first: Other ages, seasons, lasting effects, severe disease/hospitalization and treatment effects are unverified. Do not transfer laboratory-confirmed prevention results into treatment effects.
Further research: Material needed: Other ages, seasons, lasting effects, severe disease/hospitalization and treatment effects are unverified. Do not transfer laboratory-confirmed prevention results into treatment effects. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Age, season, duration, severe disease/hospitalization and treatment boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Age, season, duration, severe disease/hospitalization and treatment boundaries with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

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N19 · Can one report and two questions count as independent trials?

Current findings: Laboratory-confirmed and clinically defined questions share the same Ide report. Do not count two endpoints or sheets as new trials or populations.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Independent confirmation under the same conditions is unverified. Do not establish unique-trial, participant or independent-replication totals.
Required materials and conditions: Report, population, endpoint and sheet relationships and unique totals
Materials to obtain first: Independent confirmation under the same conditions is unverified. Do not establish unique-trial, participant or independent-replication totals.
Further research: Material needed: Independent confirmation under the same conditions is unverified. Do not establish unique-trial, participant or independent-replication totals. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Report, population, endpoint and sheet relationships and unique totals must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Report, population, endpoint and sheet relationships and unique totals with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N20 · What were public funding, support and author roles?

Current findings: Original evidence records public KAKENHI funding, described as a strength in the parent text.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Product/material support, employee authors, COI and design/analysis/publication roles are unverified. Funding information alone does not verify overall independence.
Required materials and conditions: Financial/product/material support, employee authors, COI and analysis/publication roles
Materials to obtain first: Product/material support, employee authors, COI and design/analysis/publication roles are unverified. Funding information alone does not verify overall independence.
Further research: Material needed: Product/material support, employee authors, COI and design/analysis/publication roles are unverified. Funding information alone does not verify overall independence. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Financial/product/material support, employee authors, COI and analysis/publication roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Financial/product/material support, employee authors, COI and analysis/publication roles with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N21 · Does no reported adverse event establish safety?

Current findings: Preserve the wording that no adverse events were reported in the trial and parent Good safety status.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Collection procedures, arm denominators, missingness/stopping and exact event counts are unverified. No reports do not become new safety certification or verified event counts.
Required materials and conditions: Original harm collection, arm events, denominators, missingness and stopping
Materials to obtain first: Collection procedures, arm denominators, missingness/stopping and exact event counts are unverified. No reports do not become new safety certification or verified event counts.
Further research: Material needed: Collection procedures, arm denominators, missingness/stopping and exact event counts are unverified. No reports do not become new safety certification or verified event counts. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original harm collection, arm events, denominators, missingness and stopping must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original harm collection, arm events, denominators, missingness and stopping with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N22 · Is this safe across ages, abilities and long-term exposures?

Current findings: Preserve original parent safety text and create no new gargling, infection-prevention or treatment instructions.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Other ages, gargling abilities, exposures, long-term harms and alternative-cause data are unverified. Do not extend parent Good status into safety for everyone.
Required materials and conditions: Vulnerable populations, exposures, concurrent factors, alternative causes and follow-up
Materials to obtain first: Other ages, gargling abilities, exposures, long-term harms and alternative-cause data are unverified. Do not extend parent Good status into safety for everyone.
Further research: Material needed: Other ages, gargling abilities, exposures, long-term harms and alternative-cause data are unverified. Do not extend parent Good status into safety for everyone. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Vulnerable populations, exposures, concurrent factors, alternative causes and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Vulnerable populations, exposures, concurrent factors, alternative causes and follow-up with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N23 · How are verdicts, both languages and dates preserved?

Current findings: Preserve parent D with 34 points, original bilingual texts, axes, 2026-09-07, empty correction/deliberation records and subclaim D/note with absent score/status/axes.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Historical cross-checks and strengths of direct trials do not become current review, satisfied conditions or subclaim scores. Distinguish production from evidence dates.
Required materials and conditions: Parent/subclaim original values, axes, empty histories and evidence date
Materials to obtain first: Historical cross-checks and strengths of direct trials do not become current review, satisfied conditions or subclaim scores. Distinguish production from evidence dates.
Further research: Material needed: Historical cross-checks and strengths of direct trials do not become current review, satisfied conditions or subclaim scores. Distinguish production from evidence dates. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Parent/subclaim original values, axes, empty histories and evidence date must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Parent/subclaim original values, axes, empty histories and evidence date with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N24 · Which materials were actually read?

Current findings: Production used complete stored summaries and bibliography. Distinguish summary reading, unread external materials and source links.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: External papers, registration, protocols/SAPs and support originals are unread and access was not attempted. URLs/historical verification do not become current reading or link checks.
Required materials and conditions: Stored summaries, bibliography, external papers, registration, plans and support
Materials to obtain first: External papers, registration, protocols/SAPs and support originals are unread and access was not attempted. URLs/historical verification do not become current reading or link checks.
Further research: Material needed: External papers, registration, protocols/SAPs and support originals are unread and access was not attempted. URLs/historical verification do not become current reading or link checks. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Stored summaries, bibliography, external papers, registration, plans and support must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Stored summaries, bibliography, external papers, registration, plans and support with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.
Application exceptions: Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01