{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Green-tea gargling × added laboratory-confirmed influenza prevention over water",
  "language": "en",
  "translation_date": "2026-10-19",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Met": "A state used when required evidence is confirmed after user review. This production does not declare that review complete.",
    "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.",
    "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.",
    "Review incomplete": "User review pending.",
    "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.",
    "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.",
    "Not applicable": "Not used as a substitute for an evidence gap.",
    "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.",
    "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which added laboratory-confirmed prevention claim is selected?",
      "needed": "Selected claim, grade and note versus the parent verdict",
      "role": "Required",
      "role_reason": "This condition connects Selected claim, grade and note versus the parent verdict with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Selected claim, grade and note versus the parent verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The subclaim has no score, status or axes fields. Do not fill them with parent values. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Which Japanese high-school students participated?",
      "needed": "Age, recruitment, schools, exposure, baseline risk and eligibility/exclusions",
      "role": "Required",
      "role_reason": "This condition connects Age, recruitment, schools, exposure, baseline risk and eligibility/exclusions with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Age, recruitment, schools, exposure, baseline risk and eligibility/exclusions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Exact age range, school/recruitment conditions, baseline infection risk, eligibility/exclusions and baseline characteristics are unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "What green-tea gargle was studied?",
      "needed": "Product, constituents, concentration, volume, quality and actual delivery",
      "role": "Required",
      "role_reason": "This condition connects Product, constituents, concentration, volume, quality and actual delivery with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Product, constituents, concentration, volume, quality and actual delivery must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Products, catechin/constituents, concentration, volume, actual delivery and solution-quality details are unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "What are the water control and added effect?",
      "needed": "Gargling in both arms, control composition, procedures, contact and adherence",
      "role": "Required",
      "role_reason": "This condition connects Gargling in both arms, control composition, procedures, contact and adherence with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Gargling in both arms, control composition, procedures, contact and adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Matching solution procedures, volumes, delivery/contact and adherence records are unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Were allocation and evaluation roles in the open trial verified?",
      "needed": "Random sequences, allocation concealment and tester/adjudicator/analyst blinding",
      "role": "Required",
      "role_reason": "This condition connects Random sequences, allocation concealment and tester/adjudicator/analyst blinding with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Random sequences, allocation concealment and tester/adjudicator/analyst blinding must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Allocation concealment, school/arm structures and tester/event-adjudicator/analyst blinding are unverified. An open design alone does not establish absent blinding for every role. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Are randomization, FAS and testing denominators the same?",
      "needed": "Arm allocation, FAS definitions, exclusions, event assessment and missingness",
      "role": "Required",
      "role_reason": "This condition connects Arm allocation, FAS definitions, exclusions, event assessment and missingness with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Arm allocation, FAS definitions, exclusions, event assessment and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Arm randomization counts, exclusion reasons, FAS definitions and missing test data are unverified. Calculate no new attrition counts, rates or denominators. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "How was laboratory-confirmed influenza defined?",
      "needed": "Tests, diagnostic thresholds, symptoms and collection/confirmation timing",
      "role": "Required",
      "role_reason": "This condition connects Tests, diagnostic thresholds, symptoms and collection/confirmation timing with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Tests, diagnostic thresholds, symptoms and collection/confirmation timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Exact test methods, thresholds, timing, collection/confirmation, symptom criteria and handling of untested cases are unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "How are events and arm denominators assigned?",
      "needed": "Arm labels, event/person units, repeated/first events and test denominators",
      "role": "Required",
      "role_reason": "This condition connects Arm labels, event/person units, repeated/first events and test denominators with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Arm labels, event/person units, repeated/first events and test denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Repeated infections, first events and test-denominator definitions are unverified. Calculate no new risks, event rates, risk ratios or risk differences. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What are the adjusted OR, interval and P?",
      "needed": "Estimator, adjustment variables, model, denominators and interval/test relationships",
      "role": "Required",
      "role_reason": "This condition connects Estimator, adjustment variables, model, denominators and interval/test relationships with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Estimator, adjustment variables, model, denominators and interval/test relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Adjustment variables, models, standard errors and original analysis outputs are unverified. Do not turn OR into a risk ratio or HR or create new estimates. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "How are PP and FAS results distinguished?",
      "needed": "PP definitions, denominators, adherence, missingness, interval level and model",
      "role": "Required",
      "role_reason": "This condition connects PP definitions, denominators, adherence, missingness, interval level and model with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for PP definitions, denominators, adherence, missingness, interval level and model must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: PP arm denominators, adherence criteria, missing-data handling, interval level and models are unverified. Do not turn PP values into FAS or clinically defined HR. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Does a registration identifier verify prospective endpoints?",
      "needed": "Registration timing, endpoint hierarchy/changes, protocol and SAP",
      "role": "Required",
      "role_reason": "This condition connects Registration timing, endpoint hierarchy/changes, protocol and SAP with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Registration timing, endpoint hierarchy/changes, protocol and SAP must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Registration timing, endpoint changes, protocols/SAPs and planned models are unread. Identifiers and historical descriptions do not establish a completed current prospective-status review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Were missingness, adherence and testing completeness verified?",
      "needed": "Suspected/untested infections, missed delivery and ITT/FAS/PP policies",
      "role": "Required",
      "role_reason": "This condition connects Suspected/untested infections, missed delivery and ITT/FAS/PP policies with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Suspected/untested infections, missed delivery and ITT/FAS/PP policies must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Missing tests, exclusions, adherence, observation completeness and sensitivity analyses are unverified. Do not fill in FAS as analysis of all randomized participants. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Were observation windows, exposure and concurrent prevention matched?",
      "needed": "Start/end, season, school environment, vaccination and shared exposure",
      "role": "Supplementary",
      "role_reason": "This condition connects Start/end, season, school environment, vaccination and shared exposure with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Start/end, season, school environment, vaccination and shared exposure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Season, exposure, school environment and arm matching of concurrent prevention/vaccination or other interventions are unverified. Provide no new prevention guidance. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Are clinically defined HR and laboratory-confirmed OR the same?",
      "needed": "Diagnostic definitions, events/denominators, timing, models, hierarchy and estimators",
      "role": "Required",
      "role_reason": "This condition connects Diagnostic definitions, events/denominators, timing, models, hierarchy and estimators with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Diagnostic definitions, events/denominators, timing, models, hierarchy and estimators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Do not substitute HR values/intervals for laboratory-confirmed OR or identical denominators. Original links for definitions, analyses, hierarchy, time origins and interval types are unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "How are wide intervals and null results interpreted?",
      "needed": "Planned comparisons, possible effect ranges and clinical importance",
      "role": "Required",
      "role_reason": "This condition connects Planned comparisons, possible effect ranges and clinical importance with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Planned comparisons, possible effect ranges and clinical importance must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Clinical importance thresholds and sample planning are unverified. Create no new effects, CIs, absolute effects, equivalence, grade F or certain prevention. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Can drinking, capsules or observations support this effect?",
      "needed": "Exposure routes, formulations, populations, designs and separate questions",
      "role": "Required",
      "role_reason": "This condition connects Exposure routes, formulations, populations, designs and separate questions with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Exposure routes, formulations, populations, designs and separate questions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Do not transfer numbers from other routes, populations or designs into the selected added effect. Those materials were not newly read this run. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Is another gargling verdict the same intervention?",
      "needed": "Povidone-iodine/water versus the selected green-tea/water comparison",
      "role": "Required",
      "role_reason": "This condition connects Povidone-iodine/water versus the selected green-tea/water comparison with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Povidone-iodine/water versus the selected green-tea/water comparison must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Do not newly read 720 or combine it as replication in this sheet. Do not use other-gargle effects to strengthen this result. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Does this answer other populations, long-term, severe-disease or treatment effects?",
      "needed": "Age, season, duration, severe disease/hospitalization and treatment boundaries",
      "role": "Required",
      "role_reason": "This condition connects Age, season, duration, severe disease/hospitalization and treatment boundaries with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Age, season, duration, severe disease/hospitalization and treatment boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Other ages, seasons, lasting effects, severe disease/hospitalization and treatment effects are unverified. Do not transfer laboratory-confirmed prevention results into treatment effects. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Can one report and two questions count as independent trials?",
      "needed": "Report, population, endpoint and sheet relationships and unique totals",
      "role": "Required",
      "role_reason": "This condition connects Report, population, endpoint and sheet relationships and unique totals with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Report, population, endpoint and sheet relationships and unique totals must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Independent confirmation under the same conditions is unverified. Do not establish unique-trial, participant or independent-replication totals. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "What were public funding, support and author roles?",
      "needed": "Financial/product/material support, employee authors, COI and analysis/publication roles",
      "role": "Required",
      "role_reason": "This condition connects Financial/product/material support, employee authors, COI and analysis/publication roles with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Financial/product/material support, employee authors, COI and analysis/publication roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Product/material support, employee authors, COI and design/analysis/publication roles are unverified. Funding information alone does not verify overall independence. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Does no reported adverse event establish safety?",
      "needed": "Original harm collection, arm events, denominators, missingness and stopping",
      "role": "Supplementary",
      "role_reason": "This condition connects Original harm collection, arm events, denominators, missingness and stopping with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Original harm collection, arm events, denominators, missingness and stopping must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Collection procedures, arm denominators, missingness/stopping and exact event counts are unverified. No reports do not become new safety certification or verified event counts. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Is this safe across ages, abilities and long-term exposures?",
      "needed": "Vulnerable populations, exposures, concurrent factors, alternative causes and follow-up",
      "role": "Supplementary",
      "role_reason": "This condition connects Vulnerable populations, exposures, concurrent factors, alternative causes and follow-up with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Vulnerable populations, exposures, concurrent factors, alternative causes and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Other ages, gargling abilities, exposures, long-term harms and alternative-cause data are unverified. Do not extend parent Good status into safety for everyone. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "How are verdicts, both languages and dates preserved?",
      "needed": "Parent/subclaim original values, axes, empty histories and evidence date",
      "role": "Required",
      "role_reason": "This condition connects Parent/subclaim original values, axes, empty histories and evidence date with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Parent/subclaim original values, axes, empty histories and evidence date must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Historical cross-checks and strengths of direct trials do not become current review, satisfied conditions or subclaim scores. Distinguish production from evidence dates. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Which materials were actually read?",
      "needed": "Stored summaries, bibliography, external papers, registration, plans and support",
      "role": "Required",
      "role_reason": "This condition connects Stored summaries, bibliography, external papers, registration, plans and support with added green-tea effects over water gargling, laboratory-confirmed versus clinically defined outcomes, events, denominators, FAS/PP, OR/HR, precision and harm boundaries.",
      "application_exception": "Preserve selected D and its null OR-interval note. Distinguish absent subclaim score/status/axes from parent D with 34 points. Water controls do not become no-gargling controls; OR, PP and clinical HR do not become the same analysis. Create no new effects, rates, CIs, totals, grades, independence/safety certification or gargling, infection-prevention or treatment instructions.",
      "criterion": "Material for Stored summaries, bibliography, external papers, registration, plans and support must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: External papers, registration, protocols/SAPs and support originals are unread and access was not attempted. URLs/historical verification do not become current reading or link checks. This records needed materials; no new research was executed."
    }
  ]
}