Combined breathing added to standard care × six-week SBP: evidence checklist

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionWhich 6-week SBP question is selected?Required	The selected wording is lower 6-week SBP added to standard care. The parent verdict concerns 6-week systolic pressure in treated adults with hypertension; another subclaim concerns DBP/HRV. Preserve the existing selected question without counting new independent replication. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Adjunct 6-week SBP claim and boundaries of other outcomes	Material needed: Detailed prospective analyses and endpoint hierarchy for the selected question are unverified. This records needed materials; no new research was executed.
2	Partly verified	Full text not readStored summary read	N02 · Evidence conditionHow are selected grade and parent score distinguished?Required	Selected original grade is C, with a note that final values differed but adjusted effect/CI were unverified. Selected-question score/status are unrecorded. Parent C with 50 points and caution are historical context, not a new subclaim score.	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Selected C, original note, absent score/status and parent C with 50 points	Material needed: Selected-question score/status fields are unrecorded. This records needed materials; no new research was executed.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionWhich adults with hypertension do the 6-week results concern?Required	Original descriptions concern adults with hypertension continuing medication and lifestyle management. Age, baseline SBP, severity, comorbidities, eligibility, exclusions and recruitment characteristics are unverified in the stored summary. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Treated participants, eligibility, baseline pressure, severity and comorbidities	Material needed: Detailed eligibility, baseline risk, recruitment and comorbidity materials are needed. This records needed materials; no new research was executed.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionHow does the combined intervention differ from alternate-nostril breathing alone?Required	The original study describes 2 minutes of abdominal breathing followed by 10 minutes of Nadi Shodhana, explicitly not alternate-nostril breathing alone. Component-specific SBP contributions and direct standalone comparisons are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Abdominal breathing for 2 minutes before 10 minutes of alternate-nostril breathing	Material needed: Component contributions and direct standalone alternate-nostril comparisons are needed. This records needed materials; no new research was executed.
5	Partly verified	Full text not readStored summary read	N05 · Evidence conditionWhat original information describes daily exposure and duration?Required	Original records describe adding 12 minutes daily for 6 weeks; the first 2 of 12 minutes were abdominal breathing. Actual days, frequency, adherence, discontinuation and exposure-specific SBP responses are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Daily 12-minute, 6-week plan versus actual adherence, discontinuation and assessment	Material needed: Actual adherence, discontinuation, exposure records and exposure-specific effects are needed. This records needed materials; no new research was executed.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionHow does addition to standard care differ from standalone treatment?Required	Standard management plus breathing versus standard management alone. Original records say medication/lifestyle care continued. Medication types, doses, lifestyle-management details and changes are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Continued medication/lifestyle care and the combined-breathing comparison	Material needed: Arm-specific medication/lifestyle details, changes, common care and attention controls are needed. This records needed materials; no new research was executed.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionHow do final 6-week SBP values differ from changes?Required	Original endpoints are 6-week SBP, DBP and HRV over 6 weeks. The selection is SBP; original reader-answer values are final arm values after 6 weeks. Changes, adjustments and measurement details are separately unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	SBP definition, units, final values, baseline, change and measurement	Material needed: Baseline, change, exact measurement and adjustment-model materials are needed. This records needed materials; no new research was executed.
8	Partly verified	Full text not readStored summary read	N08 · Evidence conditionWhat are the stored arm-specific final 6-week SBP statistics?Required	Original records give breathing 139.14±12.5 and control 147.79±12.8 mmHg, between-group P<.01. The evidence summary preserves the same result. The meaning of ±, exact arm analysis n and CIs are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and arm identity	Material needed: The meaning of ±, arm analysis n, CIs and test/model details are needed. This records needed materials; no new research was executed.
9	Partly verified	Full text not readStored summary read	N09 · Evidence conditionWhat does -8.65 mmHg represent?Required	Existing Korean/English records say the crude final-value difference -8.65 mmHg should not be called baseline-adjusted change. This value comes from original records; it was not newly calculated here. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original crude final-value difference versus baseline-adjusted effect	Material needed: Exact CIs, denominators and models for the crude difference are unverified. This records needed materials; no new research was executed.
10	Unverified	Full text not readStored summary read	N10 · Evidence conditionAre baseline-adjusted between-group effects and 95% CIs verified?Required	Original notes/descriptions explicitly leave adjusted between-group effects and 95% CIs unverified. Crude difference -8.65 or between-group P<.01 does not replace them. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Baseline, covariates, adjustment model, between-group effect and 95% CIs	Material needed: Adjusted effects, 95% CIs, baseline, covariates and analysis models are needed. This records needed materials; no new research was executed.
11	Partly verified	Full text not readStored summary read	N11 · Evidence conditionHow do P values differ from effect size and precision?Required	Final-SBP between-group P<.01 is preserved. The 95% CI, precise adjusted effect, prospective target and sample-size rationale are unverified; parent precision is unrecorded. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	SBP effects, CIs, clinical importance, sample-size plans and denominators	Material needed: Effect intervals, clinical thresholds, prospective plans and sample-size calculations are needed. This records needed materials; no new research was executed.
12	Partly verified	Full text not readStored summary read	N12 · Evidence conditionWhat stage does 91 randomized describe?Required	Mittal is stored as 91 randomized and 68 completed. Arm allocation n, eligibility, exclusions and recruitment flow are unverified in the summary. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original allocation of 91 and arm allocation/recruitment/eligibility flow	Material needed: Arm allocation, recruitment, eligibility and exclusion counts are needed. This records needed materials; no new research was executed.
13	Partly verified	Full text not readStored summary read	N13 · Evidence conditionHow do completion and 6-week analyses connect?Required	Original descriptions concern a complete-case analysis after 23 withdrawals. The 68 completed is original n; exact arm-specific 6-week SBP analysis n, DBP/HRV missingness and denominator identity are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	68 completed, arm completion, endpoint analysis n and complete-case definition	Material needed: Arm completion/analysis n, endpoint-specific missingness and complete-case definitions are needed. This records needed materials; no new research was executed.
14	Partly verified	Full text not readStored summary read	N14 · Evidence conditionWhat original records describe 23 withdrawals and 25.3% attrition?Required	Original records describe 25.3% attrition and complete-case analysis after 23 withdrawals. These are existing figures, not new calculations. Arm distribution, reasons, baseline differences and timing are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Attrition, arm reasons, timing, baseline risk and data loss	Material needed: Arm attrition, reasons, timing and withdrawn participants' baseline/outcome data are needed. This records needed materials; no new research was executed.
15	Unverified	Full text not readStored summary read	N15 · Evidence conditionWhich intervention effect does the complete-case result estimate?Required	Original records identify complete-case analysis and high attrition as limitations. ITT estimates for all 91 participants, imputation, sensitivity, actual-use and adjusted analyses are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	ITT, PP, complete cases, missingness, medication, adherence and sensitivity	Material needed: ITT/PP, missingness handling, sensitivity, effects of interest and original models are needed. This records needed materials; no new research was executed.
16	Partly verified	Full text not readStored summary read	N16 · Evidence conditionWhat is known about allocation, concealment and recruitment?Required	Mittal is stored as a randomized adjunct-to-standard-management trial. Actual generation, concealment, recruitment order, baseline balance and analysis procedures are unverified in the summary. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Random-sequence generation, concealment, recruitment order, baseline and assessment	Material needed: Allocation generation, concealment, recruitment and baseline-balance procedures are needed. This records needed materials; no new research was executed.
17	Unverified	Full text not readStored summary read	N17 · Evidence conditionAre participant, instructor and assessor awareness/contact known?Required	The original comparison is added breathing versus standard management. Contact time, control activities, assessor/analyst allocation awareness and actual blinding procedures are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Attention/time controls, instruction, contact and measurement/analysis blinding	Material needed: Attention/contact controls, instructors and measurement/analysis blinding materials are needed. This records needed materials; no new research was executed.
18	Unverified	Full text not readStored summary read	N18 · Evidence conditionCan baseline pressure and arm differences be linked to final values?Required	Original records do not call the -8.65 final-value difference baseline-adjusted change. Exact arm baseline SBP, changes, covariates and adjustment details are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Arm baseline SBP/DBP, medication, risk and baseline handling	Material needed: Baseline SBP/DBP, medication/risk balance and model handling are needed. This records needed materials; no new research was executed.
19	Unverified	Full text not readStored summary read	N19 · Evidence conditionHow was 6-week SBP measured?Required	Original wording describes 6-week systolic pressure in mmHg. Exact devices, office/home/ambulatory pressure, repeat averages, rest, timing and assessor methods are unverified in the summary. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Device, posture, rest, repetitions, setting, time and assessors	Material needed: Measurement devices, settings, repetitions, rest, timing and assessors are needed. This records needed materials; no new research was executed.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionHow does continued medication differ from actual prescription changes?Required	Original records describe an adjunct with medication/lifestyle management continued. Arm medication types, doses, adherence, changes, rescue prescriptions and handling in SBP analyses are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Arm medication types, doses, changes, adherence, rescue drugs and timing	Material needed: Actual medication, doses, adherence, changes and model handling are needed. This records needed materials; no new research was executed.
21	Partly verified	Full text not readStored summary read	N21 · Evidence conditionAre lifestyle care and other breathing/yoga comparisons distinguished?Required	Original descriptions say other pranayama or combined-yoga results were not used. Specific standard lifestyle care and changes are unverified; Ghiya's other-breathing comparison is a separate acute HRV context. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Standard lifestyle management, exercise, diet, contact and other-intervention boundaries	Material needed: Lifestyle content, arm changes and adherence to other interventions are needed. This records needed materials; no new research was executed.
22	Partly verified	Full text not readStored summary read	N22 · Evidence conditionAre actual breathing exposure and discontinuation linked to analyses?Required	Preserve the original daily 6-week plan, 91 allocated and 68 completed. Actual adherence, instruction, discontinuation reasons and completion-exposure relationships are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Actual delivery, instruction, adherence, discontinuation, exposure/completion denominators and analysis	Material needed: Adherence, actual exposure, discontinuation reasons and attrition relationships are needed. This records needed materials; no new research was executed.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionIs the CTRI identifier separate from a prospective SBP plan?Required	Mittal's original registration wording is CTRI/2023/11/059625. Original descriptions explicitly leave official prospective endpoints unverified. Listing SBP, DBP and HRV does not establish prospective hierarchy. Registration contents, dates and changes were unread this time. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	CTRI/2023/11/059625, registration, plans, endpoint hierarchy and timing	Material needed: Registration contents, prospective endpoints, recruitment/registration dates and plan amendments are needed. This records needed materials; no new research was executed.
24	Partly verified	Full text not readStored summary read	N24 · Evidence conditionHow is the null DBP wording preserved?Required	Mittal's original results are between-group SBP P<.01 and DBP P>.05. Parent descriptions call DBP null; the other subclaim's original grade is D. Distinguish selected SBP C and retain unverified exact DBP effects/CIs. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Between-group DBP P>.05 versus SBP, effects, CIs and denominators	Material needed: Exact DBP values, arm denominators, effects, CIs and plans are needed. This records needed materials; no new research was executed.
25	Partly verified	Full text not readStored summary read	N25 · Evidence conditionHow does 6-week SBP differ from main-trial HRV?Required	Original descriptions say HRV varied by measure. Endpoints are 6-week SBP, DBP and HRV; the other subclaim note also says HRV varied by measure/study. Specific measures, effects, CIs and analyses are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Mittal HRV measures, units, timing and analyses versus SBP	Material needed: HRV measures, units, effects, CIs, timing and denominators are needed. This records needed materials; no new research was executed.
26	Partly verified	Full text not readStored summary read	N26 · Evidence conditionIs the 100-participant HRV comparison direct 6-week SBP evidence?Required	Ghiya is stored as 100 participants, an acute comparison with another pranayama and null between-group HRV. Original records describe indirect HRV context; the citation note says it is not 6-week pressure replication. R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Ghiya's other-pranayama acute HRV comparison, original null result and identity	Material needed: Exact acute HRV measures, effects, CIs, population, denominators and registration are needed. This records needed materials; no new research was executed.
27	Partly verified	Full text not readStored summary read	N27 · Evidence conditionHow are reports, populations and endpoints kept from double-counting?Required	Mittal SBP, DBP and HRV are measures from one stored report. Ghiya is another comparator/acute HRV report. Preserve identities without calculating or establishing unique-trial/participant totals or independent 6-week SBP replication counts. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Mittal/Ghiya bibliographies, registration and report/trial/cohort links	Material needed: Report/cohort overlap, registration links and unique-participant/trial counts are unverified. This records needed materials; no new research was executed.
28	Partly verified	Full text not readStored summary read	N28 · Evidence conditionWhat is the verification level of public/academic support wording?Required	Mittal is stored as reported public/academic support; Ghiya as academic research. Specific institutions, amounts, design/analysis involvement, COI, instructor/assessor roles and report independence are unverified. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Report-specific support, COI, roles and independence	Material needed: Support/COI details, involvement, researcher roles and independence materials are needed. This records needed materials; no new research was executed.
29	Partly verified	Full text not readStored summary read	N29 · Evidence conditionIs independent SBP evidence available for the same population, components and duration?Required	Original grading describes a short-term SBP signal and says acute HRV was not counted as independent 6-week pressure replication. Independent direct SBP materials matching components, population and duration are unverified within the stored scope. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Direct follow-up with matching combined adjunct, population, measurements and denominators	Material needed: Independent direct evidence for the same question, condition differences and report-family relationships are needed. This records needed materials; no new research was executed.
30	Unverified	Full text not readStored summary read	N30 · Evidence conditionDoes the 6-week effect persist after the program ends?Required	The original verdict identifies short follow-up as a limitation. Post-program pressure, continued/discontinued practice, medication/lifestyle changes and persistence are unverified in the stored summary. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Post-program follow-up, medication, lifestyle care, continuation/discontinuation and pressure	Material needed: Post-program follow-up, exposure/treatment changes and sustained SBP materials are needed. This records needed materials; no new research was executed.
31	Partly verified	Full text not readStored summary read	N31 · Evidence conditionDoes a final-SBP signal answer cardiovascular-event or medication-replacement questions?Required	Original summaries say this is not evidence of a standalone effect or medication replacement. Short-term final values are not extended into treatment replacement or long-term events. Direct cardiovascular-event/medication-reduction effects are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Pressure surrogates versus separate clinical-event/medication-change comparisons	Material needed: Direct long-term clinical-event, medication-change and replacement materials are needed. This records needed materials; no new research was executed.
32	Partly verified	Full text not readStored summary read	N32 · Evidence conditionWhat level of material was actually read?Required	The complete stored parent-verdict summary was read and a copy preserved. Mittal/Ghiya bibliographies and report summaries were read; external abstracts, full texts, registration, plans and support materials were unread, with access unattempted. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Stored summaries/bibliographies versus external abstracts, full texts, registration and plans	Material needed: External materials were unread; inaccessibility or access failure was not verified either. This records needed materials; no new research was executed.
33	Partly verified	Full text not readStored summary read	N33 · Evidence conditionHow are the original date, production and review separated?Required	The original evidence date is 2026-09-07; corrections are an empty array and deliberation an empty string. Cross-check applied in the parent verdict is a historical record, not completion of current review.	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original evidence date, empty correction/deliberation records and historical grade decisions	Material needed: Current content-review and new clinical-verification dates are undetermined. This records needed materials; no new research was executed.
34	Partly verified	Full text not readStored summary read	N34 · Evidence conditionAre both original languages' boundaries preserved?Required	Selected English wording concerns 6-week SBP added to standard care; its note separates final-value differences from unverified adjusted effects/CIs. Parent English describes combined breathing, addition to medication/lifestyle care, 25.3% attrition and crude-difference boundaries.	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Selected claims/notes and combined adjunct, final-value, adjustment and attrition boundaries	Material needed: Detailed comparison of external papers, Korean/English translations and corrections is unverified. This records needed materials; no new research was executed.
35	Partly verified	Full text not readStored summary read	N35 · Evidence conditionHow are parent axes and absent selected-question fields preserved?Required	Parent axes are B/S/R1/I2/EX/B2, with precision unrecorded. Coprimary split, large hard-outcome trial, no human study and 1st-endpoint failure followed by a positive 2nd endpoint are all false; derived grade is C and override reasons are empty strings. The selected question has no separate score/status/axes.	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	B/S/R1/I2/EX/B2, unrecorded precision, original booleans and empty overrides	Material needed: Preserve absent selected score/status/axes and unverified precision. This records needed materials; no new research was executed.
36	Partly verified	Full text not readStored summary read	N36 · Evidence conditionHow were harms defined and collected?Supplementary; required for extending safety conclusions	Original safety is caution, with warnings about hyperventilation, dizziness and distress. Actual counts, active/passive collection, assessors and original harm tables are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original hyperventilation, dizziness and distress warnings versus actual events	Material needed: Harm definitions, collection procedures, assessors and actual event tables are needed. This records needed materials; no new research was executed.
37	Unverified	Full text not readStored summary read	N37 · Evidence conditionAre exposure, discontinuation, symptoms and follow-up timing known?Supplementary; required for extending safety conclusions	The daily 6-week exposure plan is preserved. Symptom onset, discontinuation timing, recurrence, recovery and later harm follow-up are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Actual exposure, symptom/discontinuation timing and during/post-study follow-up	Material needed: Harm timing, recurrence, recovery and later follow-up are needed. This records needed materials; no new research was executed.
38	Unverified	Full text not readStored summary read	N38 · Evidence conditionWere harms compared with standard care using the same methods?Supplementary; required for extending safety conclusions	The adjunct-to-standard-care comparison is preserved. Matching arm harm collection, observation periods and comparative event results are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Arm harm collection, observation windows, cointerventions, discontinuation and comparative tables	Material needed: Comparative harms, matching collection/follow-up and original tables are needed. This records needed materials; no new research was executed.
39	Unverified	Full text not readStored summary read	N39 · Evidence conditionAre event counts and exposure denominators available for harm frequencies?Supplementary; required for extending safety conclusions	There are 91 randomized, 68 completed and original 23 withdrawals/25.3% attrition. Harm counts, exposure/observation denominators and discontinuation reasons are separately unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Actual exposure, observation/analysis n, attrition, harm counts and observation windows	Material needed: Harm counts, exposure/observation denominators and discontinuation reasons are needed. This records needed materials; no new research was executed.
40	Partly verified	Full text not readStored summary read	N40 · Evidence conditionAre medication, lifestyle care and other exposures separated from harm causes?Supplementary; required for extending safety conclusions	Original context is an adjunct with medication/lifestyle management continued. Actual harm relationships with other diseases/treatments, causality judgments and timing are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Concurrent medication/lifestyle care, baseline disease, attrition and event sequence	Material needed: Concurrent factors, actual events, causality judgments and timing are needed. This records needed materials; no new research was executed.
41	Unverified	Full text not readStored summary read	N41 · Evidence conditionHow do completion/attrition differ from missing harm reports?Supplementary; required for extending safety conclusions	High attrition and complete-case analysis appear in original records. Discontinuation because of harm, omitted symptom reports and later follow-up collection are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Attrition/discontinuation reasons, missing symptoms, selective reporting and follow-up	Material needed: Harm-related discontinuation, missing data, selective reporting and later follow-up are needed. This records needed materials; no new research was executed.
42	Unverified	Full text not readStored summary read	N42 · Evidence conditionWhat is known about independent, vulnerable-population and later harms?Supplementary; required for extending safety conclusions	Stored scope is a short adjunctive SBP trial and an indirect acute HRV report. Independent harms under the same exposure, vulnerable groups and events after 6 weeks are unverified; no new search was done. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Matching combined exposure, independent reports, vulnerable groups and later harms	Material needed: Independent harm, vulnerable-population and later follow-up materials are needed. This records needed materials; no new research was executed.
43	Partly verified	Full text not readStored summary read	N43 · Evidence conditionHow do method copies, frozen conditions, application and content review differ?Required	Preserved copies of 5 method HTML files, applied conditions and the review contract are linked. Condition freezing and observation application are separate; creation and existing production-wording correction histories are preserved. Content/claim-boundary review remains incomplete.	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Method copies, applied conditions, originals, versions and creation/application history	Material needed: This does not indicate completed content review or new official-method/clinical certification. This records needed materials; no new research was executed.

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43 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-09-07
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: Adults with hypertension continued medication and lifestyle management. Mittal has 91 randomized and 68 completed; preserve original 23 withdrawals and 25.3% attrition. Age, baseline pressure, comorbidities and arm allocation/analysis denominators are unverified. Ghiya has a separate 100-participant acute HRV report.
Ingredient, formulation and route: The study added a combined alternate-nostril breathing program preceded by abdominal breathing to standard care. This is not converted into standalone alternate-nostril, other pranayama or combined-yoga effects. Component contributions, actual delivery, instruction and adherence are unverified.
Dose: Original study identifiers are 2 minutes of abdominal breathing followed by 10 minutes of alternate-nostril breathing, 12 minutes daily for 6 weeks. Actual exposure, adherence and discontinuation are unverified. This plan is not turned into personal breathing procedures, medication reduction/replacement or treatment instructions.
Comparator: Combined breathing added to standard management versus standard management alone. Actual medication types, doses, changes, lifestyle care and contact/attention controls are unverified. Ghiya's other-pranayama comparator is a separate acute HRV context.
Measured outcome: The selection is final 6-week SBP: breathing 139.14±12.5 versus control 147.79±12.8 mmHg, between-group P<.01. The meaning of ±, denominators, adjusted between-group effects and 95% CIs are unverified. Crude final-value difference -8.65 mmHg is an existing record, not adjusted change, ITT or a personal effect. DBP P>.05 and HRV are separate.
Duration: Direct SBP context spans 6 weeks; Ghiya is an acute HRV comparison. Post-training persistence, harm follow-up, medication changes and long-term clinical events are unverified. Short-term final values are not extended into long-term effects or treatment replacement.
Questions outside this scope: Transferring final values, crude differences, P or ± into baseline-adjusted effects, 95% CIs, ITT or personal effects; Extending the combined abdominal-first adjunct into standalone alternate-nostril breathing, other yoga or medication replacement; Counting DBP, acute HRV or multiple measures from one report as independent 6-week SBP replication; Turning randomized, completed, withdrawn or other-report participants into unique-participant totals or new calculations; Turning the CTRI identifier into NCT, verified prospective endpoints or reading registration originals; Using public/academic support, original C with 50 points or caution as new independence, precision or safety certification; Creating new numbers, grades, breathing procedures, medication reduction/replacement or treatment instructions

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

R01 · Mittal G, et al. An Exploratory Randomised Trial to Assess the Effect of Nadi Shodhan Pranayama as an Adjunct Versus Standard Non-pharmacological Management in Hypertensives. Ann Neurosci. 2025. PMID: 40242728. PMCID: PMC11996816. DOI: 10.1177/09727531251318810.

PubMed

Material type: Randomized adjunct-to-standard-management trial
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary: SBP 139.14±12.5 vs 147.79±12.8, P<.01; DBP P>.05
Record level: Complete-case final values from the direct combined 6-week SBP adjunct. Preserve 91 randomized, 68 completed and original 23 withdrawals/25.3% attrition. Crude final-value difference -8.65 mmHg is not adjusted change or ITT; the meaning of ±, exact arm denominators and adjusted effects/95% CIs are unverified.
Study overlap and independent replication: Mittal SBP, DBP and HRV are measures from one stored report; Ghiya compares acute HRV with another pranayama. Report/cohort relationships and unique-trial/participant totals are unverified. Repeated measures, randomized/completed/withdrawn participants and other questions are not counted as new independent SBP trials or participant totals.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading.
Protocol	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading.
Analysis plan and original tables	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading.
Intervention and harms	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading.
Support and interests	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading.

R02 · Ghiya S, et al. Comparison of the effects of Nadi Shodhana Pranayama and Bhramari Pranayama on heart rate variability. J Ayurveda Integr Med. 2023. PMID: 37499590. PMCID: PMC10388195. DOI: 10.1016/j.jaim.2023.100774.

PubMed

Material type: Acute comparison with another pranayama
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary: Between-group HRV was null
Record level: Separate 100-participant acute HRV comparison with another pranayama; preserve the original between-group null result. This is not independent 6-week SBP replication; population, arm denominators, measure-specific effects/CIs and report-family relationships are unverified.
Study overlap and independent replication: Mittal SBP, DBP and HRV are measures from one stored report; Ghiya compares acute HRV with another pranayama. Report/cohort relationships and unique-trial/participant totals are unverified. Repeated measures, randomized/completed/withdrawn participants and other questions are not counted as new independent SBP trials or participant totals.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred.
Protocol	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred.
Analysis plan and original tables	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred.
Intervention and harms	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred.
Support and interests	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred.

Report counts versus independent study counts

Mittal SBP, DBP and HRV are measures from one stored report; Ghiya compares acute HRV with another pranayama. Report/cohort relationships and unique-trial/participant totals are unverified. Repeated measures, randomized/completed/withdrawn participants and other questions are not counted as new independent SBP trials or participant totals.

Review criteria

Version 1.1 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which 6-week SBP question is selected?

Required materials and conditions: Adjunct 6-week SBP claim and boundaries of other outcomes
Conditions for verification: Material for Adjunct 6-week SBP claim and boundaries of other outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Adjunct 6-week SBP claim and boundaries of other outcomes with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N02 · How are selected grade and parent score distinguished?

Required materials and conditions: Selected C, original note, absent score/status and parent C with 50 points
Conditions for verification: Material for Selected C, original note, absent score/status and parent C with 50 points must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Selected C, original note, absent score/status and parent C with 50 points with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N03 · Which adults with hypertension do the 6-week results concern?

Required materials and conditions: Treated participants, eligibility, baseline pressure, severity and comorbidities
Conditions for verification: Material for Treated participants, eligibility, baseline pressure, severity and comorbidities must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Treated participants, eligibility, baseline pressure, severity and comorbidities with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N04 · How does the combined intervention differ from alternate-nostril breathing alone?

Required materials and conditions: Abdominal breathing for 2 minutes before 10 minutes of alternate-nostril breathing
Conditions for verification: Material for Abdominal breathing for 2 minutes before 10 minutes of alternate-nostril breathing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Abdominal breathing for 2 minutes before 10 minutes of alternate-nostril breathing with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N05 · What original information describes daily exposure and duration?

Required materials and conditions: Daily 12-minute, 6-week plan versus actual adherence, discontinuation and assessment
Conditions for verification: Material for Daily 12-minute, 6-week plan versus actual adherence, discontinuation and assessment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Daily 12-minute, 6-week plan versus actual adherence, discontinuation and assessment with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N06 · How does addition to standard care differ from standalone treatment?

Required materials and conditions: Continued medication/lifestyle care and the combined-breathing comparison
Conditions for verification: Material for Continued medication/lifestyle care and the combined-breathing comparison must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Continued medication/lifestyle care and the combined-breathing comparison with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N07 · How do final 6-week SBP values differ from changes?

Required materials and conditions: SBP definition, units, final values, baseline, change and measurement
Conditions for verification: Material for SBP definition, units, final values, baseline, change and measurement must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects SBP definition, units, final values, baseline, change and measurement with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N08 · What are the stored arm-specific final 6-week SBP statistics?

Required materials and conditions: 139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and arm identity
Conditions for verification: Material for 139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and arm identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects 139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and arm identity with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N09 · What does -8.65 mmHg represent?

Required materials and conditions: Original crude final-value difference versus baseline-adjusted effect
Conditions for verification: Material for Original crude final-value difference versus baseline-adjusted effect must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Original crude final-value difference versus baseline-adjusted effect with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N10 · Are baseline-adjusted between-group effects and 95% CIs verified?

Required materials and conditions: Baseline, covariates, adjustment model, between-group effect and 95% CIs
Conditions for verification: Material for Baseline, covariates, adjustment model, between-group effect and 95% CIs must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Baseline, covariates, adjustment model, between-group effect and 95% CIs with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N11 · How do P values differ from effect size and precision?

Required materials and conditions: SBP effects, CIs, clinical importance, sample-size plans and denominators
Conditions for verification: Material for SBP effects, CIs, clinical importance, sample-size plans and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects SBP effects, CIs, clinical importance, sample-size plans and denominators with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N12 · What stage does 91 randomized describe?

Required materials and conditions: Original allocation of 91 and arm allocation/recruitment/eligibility flow
Conditions for verification: Material for Original allocation of 91 and arm allocation/recruitment/eligibility flow must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Original allocation of 91 and arm allocation/recruitment/eligibility flow with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N13 · How do completion and 6-week analyses connect?

Required materials and conditions: 68 completed, arm completion, endpoint analysis n and complete-case definition
Conditions for verification: Material for 68 completed, arm completion, endpoint analysis n and complete-case definition must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects 68 completed, arm completion, endpoint analysis n and complete-case definition with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N14 · What original records describe 23 withdrawals and 25.3% attrition?

Required materials and conditions: Attrition, arm reasons, timing, baseline risk and data loss
Conditions for verification: Material for Attrition, arm reasons, timing, baseline risk and data loss must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Attrition, arm reasons, timing, baseline risk and data loss with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N15 · Which intervention effect does the complete-case result estimate?

Required materials and conditions: ITT, PP, complete cases, missingness, medication, adherence and sensitivity
Conditions for verification: Material for ITT, PP, complete cases, missingness, medication, adherence and sensitivity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects ITT, PP, complete cases, missingness, medication, adherence and sensitivity with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N16 · What is known about allocation, concealment and recruitment?

Required materials and conditions: Random-sequence generation, concealment, recruitment order, baseline and assessment
Conditions for verification: Material for Random-sequence generation, concealment, recruitment order, baseline and assessment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Random-sequence generation, concealment, recruitment order, baseline and assessment with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N17 · Are participant, instructor and assessor awareness/contact known?

Required materials and conditions: Attention/time controls, instruction, contact and measurement/analysis blinding
Conditions for verification: Material for Attention/time controls, instruction, contact and measurement/analysis blinding must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Attention/time controls, instruction, contact and measurement/analysis blinding with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N18 · Can baseline pressure and arm differences be linked to final values?

Required materials and conditions: Arm baseline SBP/DBP, medication, risk and baseline handling
Conditions for verification: Material for Arm baseline SBP/DBP, medication, risk and baseline handling must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Arm baseline SBP/DBP, medication, risk and baseline handling with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N19 · How was 6-week SBP measured?

Required materials and conditions: Device, posture, rest, repetitions, setting, time and assessors
Conditions for verification: Material for Device, posture, rest, repetitions, setting, time and assessors must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Device, posture, rest, repetitions, setting, time and assessors with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N20 · How does continued medication differ from actual prescription changes?

Required materials and conditions: Arm medication types, doses, changes, adherence, rescue drugs and timing
Conditions for verification: Material for Arm medication types, doses, changes, adherence, rescue drugs and timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Arm medication types, doses, changes, adherence, rescue drugs and timing with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N21 · Are lifestyle care and other breathing/yoga comparisons distinguished?

Required materials and conditions: Standard lifestyle management, exercise, diet, contact and other-intervention boundaries
Conditions for verification: Material for Standard lifestyle management, exercise, diet, contact and other-intervention boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Standard lifestyle management, exercise, diet, contact and other-intervention boundaries with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N22 · Are actual breathing exposure and discontinuation linked to analyses?

Required materials and conditions: Actual delivery, instruction, adherence, discontinuation, exposure/completion denominators and analysis
Conditions for verification: Material for Actual delivery, instruction, adherence, discontinuation, exposure/completion denominators and analysis must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Actual delivery, instruction, adherence, discontinuation, exposure/completion denominators and analysis with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N23 · Is the CTRI identifier separate from a prospective SBP plan?

Required materials and conditions: CTRI/2023/11/059625, registration, plans, endpoint hierarchy and timing
Conditions for verification: Material for CTRI/2023/11/059625, registration, plans, endpoint hierarchy and timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects CTRI/2023/11/059625, registration, plans, endpoint hierarchy and timing with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N24 · How is the null DBP wording preserved?

Required materials and conditions: Between-group DBP P>.05 versus SBP, effects, CIs and denominators
Conditions for verification: Material for Between-group DBP P>.05 versus SBP, effects, CIs and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Between-group DBP P>.05 versus SBP, effects, CIs and denominators with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N25 · How does 6-week SBP differ from main-trial HRV?

Required materials and conditions: Mittal HRV measures, units, timing and analyses versus SBP
Conditions for verification: Material for Mittal HRV measures, units, timing and analyses versus SBP must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Mittal HRV measures, units, timing and analyses versus SBP with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N26 · Is the 100-participant HRV comparison direct 6-week SBP evidence?

Required materials and conditions: Ghiya's other-pranayama acute HRV comparison, original null result and identity
Conditions for verification: Material for Ghiya's other-pranayama acute HRV comparison, original null result and identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Ghiya's other-pranayama acute HRV comparison, original null result and identity with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N27 · How are reports, populations and endpoints kept from double-counting?

Required materials and conditions: Mittal/Ghiya bibliographies, registration and report/trial/cohort links
Conditions for verification: Material for Mittal/Ghiya bibliographies, registration and report/trial/cohort links must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Mittal/Ghiya bibliographies, registration and report/trial/cohort links with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N28 · What is the verification level of public/academic support wording?

Required materials and conditions: Report-specific support, COI, roles and independence
Conditions for verification: Material for Report-specific support, COI, roles and independence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Report-specific support, COI, roles and independence with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N29 · Is independent SBP evidence available for the same population, components and duration?

Required materials and conditions: Direct follow-up with matching combined adjunct, population, measurements and denominators
Conditions for verification: Material for Direct follow-up with matching combined adjunct, population, measurements and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Direct follow-up with matching combined adjunct, population, measurements and denominators with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N30 · Does the 6-week effect persist after the program ends?

Required materials and conditions: Post-program follow-up, medication, lifestyle care, continuation/discontinuation and pressure
Conditions for verification: Material for Post-program follow-up, medication, lifestyle care, continuation/discontinuation and pressure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Post-program follow-up, medication, lifestyle care, continuation/discontinuation and pressure with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N31 · Does a final-SBP signal answer cardiovascular-event or medication-replacement questions?

Required materials and conditions: Pressure surrogates versus separate clinical-event/medication-change comparisons
Conditions for verification: Material for Pressure surrogates versus separate clinical-event/medication-change comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Pressure surrogates versus separate clinical-event/medication-change comparisons with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N32 · What level of material was actually read?

Required materials and conditions: Stored summaries/bibliographies versus external abstracts, full texts, registration and plans
Conditions for verification: Material for Stored summaries/bibliographies versus external abstracts, full texts, registration and plans must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Stored summaries/bibliographies versus external abstracts, full texts, registration and plans with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N33 · How are the original date, production and review separated?

Required materials and conditions: Original evidence date, empty correction/deliberation records and historical grade decisions
Conditions for verification: Material for Original evidence date, empty correction/deliberation records and historical grade decisions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Original evidence date, empty correction/deliberation records and historical grade decisions with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N34 · Are both original languages' boundaries preserved?

Required materials and conditions: Selected claims/notes and combined adjunct, final-value, adjustment and attrition boundaries
Conditions for verification: Material for Selected claims/notes and combined adjunct, final-value, adjustment and attrition boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Selected claims/notes and combined adjunct, final-value, adjustment and attrition boundaries with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N35 · How are parent axes and absent selected-question fields preserved?

Required materials and conditions: B/S/R1/I2/EX/B2, unrecorded precision, original booleans and empty overrides
Conditions for verification: Material for B/S/R1/I2/EX/B2, unrecorded precision, original booleans and empty overrides must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects B/S/R1/I2/EX/B2, unrecorded precision, original booleans and empty overrides with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N36 · How were harms defined and collected?

Required materials and conditions: Original hyperventilation, dizziness and distress warnings versus actual events
Conditions for verification: Material for Original hyperventilation, dizziness and distress warnings versus actual events must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary; required for extending safety conclusions
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Original hyperventilation, dizziness and distress warnings versus actual events with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N37 · Are exposure, discontinuation, symptoms and follow-up timing known?

Required materials and conditions: Actual exposure, symptom/discontinuation timing and during/post-study follow-up
Conditions for verification: Material for Actual exposure, symptom/discontinuation timing and during/post-study follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary; required for extending safety conclusions
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Actual exposure, symptom/discontinuation timing and during/post-study follow-up with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N38 · Were harms compared with standard care using the same methods?

Required materials and conditions: Arm harm collection, observation windows, cointerventions, discontinuation and comparative tables
Conditions for verification: Material for Arm harm collection, observation windows, cointerventions, discontinuation and comparative tables must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary; required for extending safety conclusions
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Arm harm collection, observation windows, cointerventions, discontinuation and comparative tables with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N39 · Are event counts and exposure denominators available for harm frequencies?

Required materials and conditions: Actual exposure, observation/analysis n, attrition, harm counts and observation windows
Conditions for verification: Material for Actual exposure, observation/analysis n, attrition, harm counts and observation windows must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary; required for extending safety conclusions
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Actual exposure, observation/analysis n, attrition, harm counts and observation windows with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N40 · Are medication, lifestyle care and other exposures separated from harm causes?

Required materials and conditions: Concurrent medication/lifestyle care, baseline disease, attrition and event sequence
Conditions for verification: Material for Concurrent medication/lifestyle care, baseline disease, attrition and event sequence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary; required for extending safety conclusions
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Concurrent medication/lifestyle care, baseline disease, attrition and event sequence with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N41 · How do completion/attrition differ from missing harm reports?

Required materials and conditions: Attrition/discontinuation reasons, missing symptoms, selective reporting and follow-up
Conditions for verification: Material for Attrition/discontinuation reasons, missing symptoms, selective reporting and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary; required for extending safety conclusions
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Attrition/discontinuation reasons, missing symptoms, selective reporting and follow-up with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N42 · What is known about independent, vulnerable-population and later harms?

Required materials and conditions: Matching combined exposure, independent reports, vulnerable groups and later harms
Conditions for verification: Material for Matching combined exposure, independent reports, vulnerable groups and later harms must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary; required for extending safety conclusions
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Matching combined exposure, independent reports, vulnerable groups and later harms with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N43 · How do method copies, frozen conditions, application and content review differ?

Required materials and conditions: Method copies, applied conditions, originals, versions and creation/application history
Conditions for verification: Material for Method copies, applied conditions, originals, versions and creation/application history must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Method copies, applied conditions, originals, versions and creation/application history with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

What the statuses mean

Met: The original content has been reviewed as meeting the conditions. This status is not used in this preparation.
Partly verified: Some information in the stored summary was linked during preparation; clinical verification or review is not complete.
Unverified: Required direct values, definitions or materials have not been established within the current storage and reading scope. This does not mean zero effect, no papers or failed access.
Review incomplete: Awaiting user review, or actual review remains incomplete.
Not reported: Used only when original materials were actually read and the outcome was judged unreported. Not used for external materials unread in this work.
Inaccessible: Used only when an actual access attempt has a recorded failure. Not used for access that was not attempted in this work.
Insufficient evidence for the conditions: Indicates insufficient direct materials for the relevant scope or conditions; it is not a new grade.
Not applicable: Used when the reason it does not apply to the original question is stated.
Conflicting data: Retains the scope of conflicting statements in original materials; it is not an arbitrary reassessment.

Change history

2026-10-18 · Public page/material version 1.0

Public pages and materials were prepared from the existing 43 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-09-07) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which 6-week SBP question is selected?

Current findings: The selected wording is lower 6-week SBP added to standard care. The parent verdict concerns 6-week systolic pressure in treated adults with hypertension; another subclaim concerns DBP/HRV. Preserve the existing selected question without counting new independent replication.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Detailed prospective analyses and endpoint hierarchy for the selected question are unverified.
Required materials and conditions: Adjunct 6-week SBP claim and boundaries of other outcomes
Materials to obtain first: Detailed prospective analyses and endpoint hierarchy for the selected question are unverified.
Further research: Material needed: Detailed prospective analyses and endpoint hierarchy for the selected question are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Adjunct 6-week SBP claim and boundaries of other outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Adjunct 6-week SBP claim and boundaries of other outcomes with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N02 · How are selected grade and parent score distinguished?

Current findings: Selected original grade is C, with a note that final values differed but adjusted effect/CI were unverified. Selected-question score/status are unrecorded. Parent C with 50 points and caution are historical context, not a new subclaim score.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Selected-question score/status fields are unrecorded.
Required materials and conditions: Selected C, original note, absent score/status and parent C with 50 points
Materials to obtain first: Selected-question score/status fields are unrecorded.
Further research: Material needed: Selected-question score/status fields are unrecorded. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Selected C, original note, absent score/status and parent C with 50 points must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Selected C, original note, absent score/status and parent C with 50 points with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

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N03 · Which adults with hypertension do the 6-week results concern?

Current findings: Original descriptions concern adults with hypertension continuing medication and lifestyle management. Age, baseline SBP, severity, comorbidities, eligibility, exclusions and recruitment characteristics are unverified in the stored summary.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Detailed eligibility, baseline risk, recruitment and comorbidity materials are needed.
Required materials and conditions: Treated participants, eligibility, baseline pressure, severity and comorbidities
Materials to obtain first: Detailed eligibility, baseline risk, recruitment and comorbidity materials are needed.
Further research: Material needed: Detailed eligibility, baseline risk, recruitment and comorbidity materials are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Treated participants, eligibility, baseline pressure, severity and comorbidities must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Treated participants, eligibility, baseline pressure, severity and comorbidities with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

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N04 · How does the combined intervention differ from alternate-nostril breathing alone?

Current findings: The original study describes 2 minutes of abdominal breathing followed by 10 minutes of Nadi Shodhana, explicitly not alternate-nostril breathing alone. Component-specific SBP contributions and direct standalone comparisons are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Component contributions and direct standalone alternate-nostril comparisons are needed.
Required materials and conditions: Abdominal breathing for 2 minutes before 10 minutes of alternate-nostril breathing
Materials to obtain first: Component contributions and direct standalone alternate-nostril comparisons are needed.
Further research: Material needed: Component contributions and direct standalone alternate-nostril comparisons are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Abdominal breathing for 2 minutes before 10 minutes of alternate-nostril breathing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Abdominal breathing for 2 minutes before 10 minutes of alternate-nostril breathing with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N05 · What original information describes daily exposure and duration?

Current findings: Original records describe adding 12 minutes daily for 6 weeks; the first 2 of 12 minutes were abdominal breathing. Actual days, frequency, adherence, discontinuation and exposure-specific SBP responses are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Actual adherence, discontinuation, exposure records and exposure-specific effects are needed.
Required materials and conditions: Daily 12-minute, 6-week plan versus actual adherence, discontinuation and assessment
Materials to obtain first: Actual adherence, discontinuation, exposure records and exposure-specific effects are needed.
Further research: Material needed: Actual adherence, discontinuation, exposure records and exposure-specific effects are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Daily 12-minute, 6-week plan versus actual adherence, discontinuation and assessment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Daily 12-minute, 6-week plan versus actual adherence, discontinuation and assessment with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N06 · How does addition to standard care differ from standalone treatment?

Current findings: Standard management plus breathing versus standard management alone. Original records say medication/lifestyle care continued. Medication types, doses, lifestyle-management details and changes are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm-specific medication/lifestyle details, changes, common care and attention controls are needed.
Required materials and conditions: Continued medication/lifestyle care and the combined-breathing comparison
Materials to obtain first: Arm-specific medication/lifestyle details, changes, common care and attention controls are needed.
Further research: Material needed: Arm-specific medication/lifestyle details, changes, common care and attention controls are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Continued medication/lifestyle care and the combined-breathing comparison must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Continued medication/lifestyle care and the combined-breathing comparison with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N07 · How do final 6-week SBP values differ from changes?

Current findings: Original endpoints are 6-week SBP, DBP and HRV over 6 weeks. The selection is SBP; original reader-answer values are final arm values after 6 weeks. Changes, adjustments and measurement details are separately unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Baseline, change, exact measurement and adjustment-model materials are needed.
Required materials and conditions: SBP definition, units, final values, baseline, change and measurement
Materials to obtain first: Baseline, change, exact measurement and adjustment-model materials are needed.
Further research: Material needed: Baseline, change, exact measurement and adjustment-model materials are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for SBP definition, units, final values, baseline, change and measurement must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects SBP definition, units, final values, baseline, change and measurement with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N08 · What are the stored arm-specific final 6-week SBP statistics?

Current findings: Original records give breathing 139.14±12.5 and control 147.79±12.8 mmHg, between-group P<.01. The evidence summary preserves the same result. The meaning of ±, exact arm analysis n and CIs are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: The meaning of ±, arm analysis n, CIs and test/model details are needed.
Required materials and conditions: 139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and arm identity
Materials to obtain first: The meaning of ±, arm analysis n, CIs and test/model details are needed.
Further research: Material needed: The meaning of ±, arm analysis n, CIs and test/model details are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for 139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and arm identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects 139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and arm identity with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N09 · What does -8.65 mmHg represent?

Current findings: Existing Korean/English records say the crude final-value difference -8.65 mmHg should not be called baseline-adjusted change. This value comes from original records; it was not newly calculated here.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Exact CIs, denominators and models for the crude difference are unverified.
Required materials and conditions: Original crude final-value difference versus baseline-adjusted effect
Materials to obtain first: Exact CIs, denominators and models for the crude difference are unverified.
Further research: Material needed: Exact CIs, denominators and models for the crude difference are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original crude final-value difference versus baseline-adjusted effect must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original crude final-value difference versus baseline-adjusted effect with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N10 · Are baseline-adjusted between-group effects and 95% CIs verified?

Current findings: Original notes/descriptions explicitly leave adjusted between-group effects and 95% CIs unverified. Crude difference -8.65 or between-group P<.01 does not replace them.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Adjusted effects, 95% CIs, baseline, covariates and analysis models are needed.
Required materials and conditions: Baseline, covariates, adjustment model, between-group effect and 95% CIs
Materials to obtain first: Adjusted effects, 95% CIs, baseline, covariates and analysis models are needed.
Further research: Material needed: Adjusted effects, 95% CIs, baseline, covariates and analysis models are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Baseline, covariates, adjustment model, between-group effect and 95% CIs must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Baseline, covariates, adjustment model, between-group effect and 95% CIs with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N11 · How do P values differ from effect size and precision?

Current findings: Final-SBP between-group P<.01 is preserved. The 95% CI, precise adjusted effect, prospective target and sample-size rationale are unverified; parent precision is unrecorded.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Effect intervals, clinical thresholds, prospective plans and sample-size calculations are needed.
Required materials and conditions: SBP effects, CIs, clinical importance, sample-size plans and denominators
Materials to obtain first: Effect intervals, clinical thresholds, prospective plans and sample-size calculations are needed.
Further research: Material needed: Effect intervals, clinical thresholds, prospective plans and sample-size calculations are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for SBP effects, CIs, clinical importance, sample-size plans and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects SBP effects, CIs, clinical importance, sample-size plans and denominators with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

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N12 · What stage does 91 randomized describe?

Current findings: Mittal is stored as 91 randomized and 68 completed. Arm allocation n, eligibility, exclusions and recruitment flow are unverified in the summary.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm allocation, recruitment, eligibility and exclusion counts are needed.
Required materials and conditions: Original allocation of 91 and arm allocation/recruitment/eligibility flow
Materials to obtain first: Arm allocation, recruitment, eligibility and exclusion counts are needed.
Further research: Material needed: Arm allocation, recruitment, eligibility and exclusion counts are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original allocation of 91 and arm allocation/recruitment/eligibility flow must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original allocation of 91 and arm allocation/recruitment/eligibility flow with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

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N13 · How do completion and 6-week analyses connect?

Current findings: Original descriptions concern a complete-case analysis after 23 withdrawals. The 68 completed is original n; exact arm-specific 6-week SBP analysis n, DBP/HRV missingness and denominator identity are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm completion/analysis n, endpoint-specific missingness and complete-case definitions are needed.
Required materials and conditions: 68 completed, arm completion, endpoint analysis n and complete-case definition
Materials to obtain first: Arm completion/analysis n, endpoint-specific missingness and complete-case definitions are needed.
Further research: Material needed: Arm completion/analysis n, endpoint-specific missingness and complete-case definitions are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for 68 completed, arm completion, endpoint analysis n and complete-case definition must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects 68 completed, arm completion, endpoint analysis n and complete-case definition with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

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N14 · What original records describe 23 withdrawals and 25.3% attrition?

Current findings: Original records describe 25.3% attrition and complete-case analysis after 23 withdrawals. These are existing figures, not new calculations. Arm distribution, reasons, baseline differences and timing are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm attrition, reasons, timing and withdrawn participants' baseline/outcome data are needed.
Required materials and conditions: Attrition, arm reasons, timing, baseline risk and data loss
Materials to obtain first: Arm attrition, reasons, timing and withdrawn participants' baseline/outcome data are needed.
Further research: Material needed: Arm attrition, reasons, timing and withdrawn participants' baseline/outcome data are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Attrition, arm reasons, timing, baseline risk and data loss must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Attrition, arm reasons, timing, baseline risk and data loss with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

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N15 · Which intervention effect does the complete-case result estimate?

Current findings: Original records identify complete-case analysis and high attrition as limitations. ITT estimates for all 91 participants, imputation, sensitivity, actual-use and adjusted analyses are unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: ITT/PP, missingness handling, sensitivity, effects of interest and original models are needed.
Required materials and conditions: ITT, PP, complete cases, missingness, medication, adherence and sensitivity
Materials to obtain first: ITT/PP, missingness handling, sensitivity, effects of interest and original models are needed.
Further research: Material needed: ITT/PP, missingness handling, sensitivity, effects of interest and original models are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for ITT, PP, complete cases, missingness, medication, adherence and sensitivity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects ITT, PP, complete cases, missingness, medication, adherence and sensitivity with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N16 · What is known about allocation, concealment and recruitment?

Current findings: Mittal is stored as a randomized adjunct-to-standard-management trial. Actual generation, concealment, recruitment order, baseline balance and analysis procedures are unverified in the summary.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Allocation generation, concealment, recruitment and baseline-balance procedures are needed.
Required materials and conditions: Random-sequence generation, concealment, recruitment order, baseline and assessment
Materials to obtain first: Allocation generation, concealment, recruitment and baseline-balance procedures are needed.
Further research: Material needed: Allocation generation, concealment, recruitment and baseline-balance procedures are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Random-sequence generation, concealment, recruitment order, baseline and assessment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Random-sequence generation, concealment, recruitment order, baseline and assessment with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N17 · Are participant, instructor and assessor awareness/contact known?

Current findings: The original comparison is added breathing versus standard management. Contact time, control activities, assessor/analyst allocation awareness and actual blinding procedures are unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Attention/contact controls, instructors and measurement/analysis blinding materials are needed.
Required materials and conditions: Attention/time controls, instruction, contact and measurement/analysis blinding
Materials to obtain first: Attention/contact controls, instructors and measurement/analysis blinding materials are needed.
Further research: Material needed: Attention/contact controls, instructors and measurement/analysis blinding materials are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Attention/time controls, instruction, contact and measurement/analysis blinding must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Attention/time controls, instruction, contact and measurement/analysis blinding with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N18 · Can baseline pressure and arm differences be linked to final values?

Current findings: Original records do not call the -8.65 final-value difference baseline-adjusted change. Exact arm baseline SBP, changes, covariates and adjustment details are unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Baseline SBP/DBP, medication/risk balance and model handling are needed.
Required materials and conditions: Arm baseline SBP/DBP, medication, risk and baseline handling
Materials to obtain first: Baseline SBP/DBP, medication/risk balance and model handling are needed.
Further research: Material needed: Baseline SBP/DBP, medication/risk balance and model handling are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Arm baseline SBP/DBP, medication, risk and baseline handling must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Arm baseline SBP/DBP, medication, risk and baseline handling with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N19 · How was 6-week SBP measured?

Current findings: Original wording describes 6-week systolic pressure in mmHg. Exact devices, office/home/ambulatory pressure, repeat averages, rest, timing and assessor methods are unverified in the summary.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Measurement devices, settings, repetitions, rest, timing and assessors are needed.
Required materials and conditions: Device, posture, rest, repetitions, setting, time and assessors
Materials to obtain first: Measurement devices, settings, repetitions, rest, timing and assessors are needed.
Further research: Material needed: Measurement devices, settings, repetitions, rest, timing and assessors are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Device, posture, rest, repetitions, setting, time and assessors must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Device, posture, rest, repetitions, setting, time and assessors with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N20 · How does continued medication differ from actual prescription changes?

Current findings: Original records describe an adjunct with medication/lifestyle management continued. Arm medication types, doses, adherence, changes, rescue prescriptions and handling in SBP analyses are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Actual medication, doses, adherence, changes and model handling are needed.
Required materials and conditions: Arm medication types, doses, changes, adherence, rescue drugs and timing
Materials to obtain first: Actual medication, doses, adherence, changes and model handling are needed.
Further research: Material needed: Actual medication, doses, adherence, changes and model handling are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Arm medication types, doses, changes, adherence, rescue drugs and timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Arm medication types, doses, changes, adherence, rescue drugs and timing with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N21 · Are lifestyle care and other breathing/yoga comparisons distinguished?

Current findings: Original descriptions say other pranayama or combined-yoga results were not used. Specific standard lifestyle care and changes are unverified; Ghiya's other-breathing comparison is a separate acute HRV context.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Lifestyle content, arm changes and adherence to other interventions are needed.
Required materials and conditions: Standard lifestyle management, exercise, diet, contact and other-intervention boundaries
Materials to obtain first: Lifestyle content, arm changes and adherence to other interventions are needed.
Further research: Material needed: Lifestyle content, arm changes and adherence to other interventions are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Standard lifestyle management, exercise, diet, contact and other-intervention boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Standard lifestyle management, exercise, diet, contact and other-intervention boundaries with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N22 · Are actual breathing exposure and discontinuation linked to analyses?

Current findings: Preserve the original daily 6-week plan, 91 allocated and 68 completed. Actual adherence, instruction, discontinuation reasons and completion-exposure relationships are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Adherence, actual exposure, discontinuation reasons and attrition relationships are needed.
Required materials and conditions: Actual delivery, instruction, adherence, discontinuation, exposure/completion denominators and analysis
Materials to obtain first: Adherence, actual exposure, discontinuation reasons and attrition relationships are needed.
Further research: Material needed: Adherence, actual exposure, discontinuation reasons and attrition relationships are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Actual delivery, instruction, adherence, discontinuation, exposure/completion denominators and analysis must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Actual delivery, instruction, adherence, discontinuation, exposure/completion denominators and analysis with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N23 · Is the CTRI identifier separate from a prospective SBP plan?

Current findings: Mittal's original registration wording is CTRI/2023/11/059625. Original descriptions explicitly leave official prospective endpoints unverified. Listing SBP, DBP and HRV does not establish prospective hierarchy. Registration contents, dates and changes were unread this time.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Registration contents, prospective endpoints, recruitment/registration dates and plan amendments are needed.
Required materials and conditions: CTRI/2023/11/059625, registration, plans, endpoint hierarchy and timing
Materials to obtain first: Registration contents, prospective endpoints, recruitment/registration dates and plan amendments are needed.
Further research: Material needed: Registration contents, prospective endpoints, recruitment/registration dates and plan amendments are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for CTRI/2023/11/059625, registration, plans, endpoint hierarchy and timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects CTRI/2023/11/059625, registration, plans, endpoint hierarchy and timing with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N24 · How is the null DBP wording preserved?

Current findings: Mittal's original results are between-group SBP P<.01 and DBP P>.05. Parent descriptions call DBP null; the other subclaim's original grade is D. Distinguish selected SBP C and retain unverified exact DBP effects/CIs.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Exact DBP values, arm denominators, effects, CIs and plans are needed.
Required materials and conditions: Between-group DBP P>.05 versus SBP, effects, CIs and denominators
Materials to obtain first: Exact DBP values, arm denominators, effects, CIs and plans are needed.
Further research: Material needed: Exact DBP values, arm denominators, effects, CIs and plans are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Between-group DBP P>.05 versus SBP, effects, CIs and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Between-group DBP P>.05 versus SBP, effects, CIs and denominators with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N25 · How does 6-week SBP differ from main-trial HRV?

Current findings: Original descriptions say HRV varied by measure. Endpoints are 6-week SBP, DBP and HRV; the other subclaim note also says HRV varied by measure/study. Specific measures, effects, CIs and analyses are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: HRV measures, units, effects, CIs, timing and denominators are needed.
Required materials and conditions: Mittal HRV measures, units, timing and analyses versus SBP
Materials to obtain first: HRV measures, units, effects, CIs, timing and denominators are needed.
Further research: Material needed: HRV measures, units, effects, CIs, timing and denominators are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Mittal HRV measures, units, timing and analyses versus SBP must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Mittal HRV measures, units, timing and analyses versus SBP with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N26 · Is the 100-participant HRV comparison direct 6-week SBP evidence?

Current findings: Ghiya is stored as 100 participants, an acute comparison with another pranayama and null between-group HRV. Original records describe indirect HRV context; the citation note says it is not 6-week pressure replication.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Exact acute HRV measures, effects, CIs, population, denominators and registration are needed.
Required materials and conditions: Ghiya's other-pranayama acute HRV comparison, original null result and identity
Materials to obtain first: Exact acute HRV measures, effects, CIs, population, denominators and registration are needed.
Further research: Material needed: Exact acute HRV measures, effects, CIs, population, denominators and registration are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Ghiya's other-pranayama acute HRV comparison, original null result and identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Ghiya's other-pranayama acute HRV comparison, original null result and identity with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02

N27 · How are reports, populations and endpoints kept from double-counting?

Current findings: Mittal SBP, DBP and HRV are measures from one stored report. Ghiya is another comparator/acute HRV report. Preserve identities without calculating or establishing unique-trial/participant totals or independent 6-week SBP replication counts.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Report/cohort overlap, registration links and unique-participant/trial counts are unverified.
Required materials and conditions: Mittal/Ghiya bibliographies, registration and report/trial/cohort links
Materials to obtain first: Report/cohort overlap, registration links and unique-participant/trial counts are unverified.
Further research: Material needed: Report/cohort overlap, registration links and unique-participant/trial counts are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Mittal/Ghiya bibliographies, registration and report/trial/cohort links must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Mittal/Ghiya bibliographies, registration and report/trial/cohort links with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N28 · What is the verification level of public/academic support wording?

Current findings: Mittal is stored as reported public/academic support; Ghiya as academic research. Specific institutions, amounts, design/analysis involvement, COI, instructor/assessor roles and report independence are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Support/COI details, involvement, researcher roles and independence materials are needed.
Required materials and conditions: Report-specific support, COI, roles and independence
Materials to obtain first: Support/COI details, involvement, researcher roles and independence materials are needed.
Further research: Material needed: Support/COI details, involvement, researcher roles and independence materials are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Report-specific support, COI, roles and independence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Report-specific support, COI, roles and independence with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N29 · Is independent SBP evidence available for the same population, components and duration?

Current findings: Original grading describes a short-term SBP signal and says acute HRV was not counted as independent 6-week pressure replication. Independent direct SBP materials matching components, population and duration are unverified within the stored scope.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Independent direct evidence for the same question, condition differences and report-family relationships are needed.
Required materials and conditions: Direct follow-up with matching combined adjunct, population, measurements and denominators
Materials to obtain first: Independent direct evidence for the same question, condition differences and report-family relationships are needed.
Further research: Material needed: Independent direct evidence for the same question, condition differences and report-family relationships are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Direct follow-up with matching combined adjunct, population, measurements and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Direct follow-up with matching combined adjunct, population, measurements and denominators with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N30 · Does the 6-week effect persist after the program ends?

Current findings: The original verdict identifies short follow-up as a limitation. Post-program pressure, continued/discontinued practice, medication/lifestyle changes and persistence are unverified in the stored summary.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Post-program follow-up, exposure/treatment changes and sustained SBP materials are needed.
Required materials and conditions: Post-program follow-up, medication, lifestyle care, continuation/discontinuation and pressure
Materials to obtain first: Post-program follow-up, exposure/treatment changes and sustained SBP materials are needed.
Further research: Material needed: Post-program follow-up, exposure/treatment changes and sustained SBP materials are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Post-program follow-up, medication, lifestyle care, continuation/discontinuation and pressure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Post-program follow-up, medication, lifestyle care, continuation/discontinuation and pressure with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N31 · Does a final-SBP signal answer cardiovascular-event or medication-replacement questions?

Current findings: Original summaries say this is not evidence of a standalone effect or medication replacement. Short-term final values are not extended into treatment replacement or long-term events. Direct cardiovascular-event/medication-reduction effects are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Direct long-term clinical-event, medication-change and replacement materials are needed.
Required materials and conditions: Pressure surrogates versus separate clinical-event/medication-change comparisons
Materials to obtain first: Direct long-term clinical-event, medication-change and replacement materials are needed.
Further research: Material needed: Direct long-term clinical-event, medication-change and replacement materials are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Pressure surrogates versus separate clinical-event/medication-change comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Pressure surrogates versus separate clinical-event/medication-change comparisons with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N32 · What level of material was actually read?

Current findings: The complete stored parent-verdict summary was read and a copy preserved. Mittal/Ghiya bibliographies and report summaries were read; external abstracts, full texts, registration, plans and support materials were unread, with access unattempted.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: External materials were unread; inaccessibility or access failure was not verified either.
Required materials and conditions: Stored summaries/bibliographies versus external abstracts, full texts, registration and plans
Materials to obtain first: External materials were unread; inaccessibility or access failure was not verified either.
Further research: Material needed: External materials were unread; inaccessibility or access failure was not verified either. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Stored summaries/bibliographies versus external abstracts, full texts, registration and plans must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Stored summaries/bibliographies versus external abstracts, full texts, registration and plans with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N33 · How are the original date, production and review separated?

Current findings: The original evidence date is 2026-09-07; corrections are an empty array and deliberation an empty string. Cross-check applied in the parent verdict is a historical record, not completion of current review.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Current content-review and new clinical-verification dates are undetermined.
Required materials and conditions: Original evidence date, empty correction/deliberation records and historical grade decisions
Materials to obtain first: Current content-review and new clinical-verification dates are undetermined.
Further research: Material needed: Current content-review and new clinical-verification dates are undetermined. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original evidence date, empty correction/deliberation records and historical grade decisions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original evidence date, empty correction/deliberation records and historical grade decisions with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources

N34 · Are both original languages' boundaries preserved?

Current findings: Selected English wording concerns 6-week SBP added to standard care; its note separates final-value differences from unverified adjusted effects/CIs. Parent English describes combined breathing, addition to medication/lifestyle care, 25.3% attrition and crude-difference boundaries.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Detailed comparison of external papers, Korean/English translations and corrections is unverified.
Required materials and conditions: Selected claims/notes and combined adjunct, final-value, adjustment and attrition boundaries
Materials to obtain first: Detailed comparison of external papers, Korean/English translations and corrections is unverified.
Further research: Material needed: Detailed comparison of external papers, Korean/English translations and corrections is unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Selected claims/notes and combined adjunct, final-value, adjustment and attrition boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Selected claims/notes and combined adjunct, final-value, adjustment and attrition boundaries with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources

N35 · How are parent axes and absent selected-question fields preserved?

Current findings: Parent axes are B/S/R1/I2/EX/B2, with precision unrecorded. Coprimary split, large hard-outcome trial, no human study and 1st-endpoint failure followed by a positive 2nd endpoint are all false; derived grade is C and override reasons are empty strings. The selected question has no separate score/status/axes.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Preserve absent selected score/status/axes and unverified precision.
Required materials and conditions: B/S/R1/I2/EX/B2, unrecorded precision, original booleans and empty overrides
Materials to obtain first: Preserve absent selected score/status/axes and unverified precision.
Further research: Material needed: Preserve absent selected score/status/axes and unverified precision. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for B/S/R1/I2/EX/B2, unrecorded precision, original booleans and empty overrides must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects B/S/R1/I2/EX/B2, unrecorded precision, original booleans and empty overrides with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources

N36 · How were harms defined and collected?

Current findings: Original safety is caution, with warnings about hyperventilation, dizziness and distress. Actual counts, active/passive collection, assessors and original harm tables are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Harm definitions, collection procedures, assessors and actual event tables are needed.
Required materials and conditions: Original hyperventilation, dizziness and distress warnings versus actual events
Materials to obtain first: Harm definitions, collection procedures, assessors and actual event tables are needed.
Further research: Material needed: Harm definitions, collection procedures, assessors and actual event tables are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original hyperventilation, dizziness and distress warnings versus actual events must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original hyperventilation, dizziness and distress warnings versus actual events with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N37 · Are exposure, discontinuation, symptoms and follow-up timing known?

Current findings: The daily 6-week exposure plan is preserved. Symptom onset, discontinuation timing, recurrence, recovery and later harm follow-up are unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Harm timing, recurrence, recovery and later follow-up are needed.
Required materials and conditions: Actual exposure, symptom/discontinuation timing and during/post-study follow-up
Materials to obtain first: Harm timing, recurrence, recovery and later follow-up are needed.
Further research: Material needed: Harm timing, recurrence, recovery and later follow-up are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Actual exposure, symptom/discontinuation timing and during/post-study follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Actual exposure, symptom/discontinuation timing and during/post-study follow-up with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N38 · Were harms compared with standard care using the same methods?

Current findings: The adjunct-to-standard-care comparison is preserved. Matching arm harm collection, observation periods and comparative event results are unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Comparative harms, matching collection/follow-up and original tables are needed.
Required materials and conditions: Arm harm collection, observation windows, cointerventions, discontinuation and comparative tables
Materials to obtain first: Comparative harms, matching collection/follow-up and original tables are needed.
Further research: Material needed: Comparative harms, matching collection/follow-up and original tables are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Arm harm collection, observation windows, cointerventions, discontinuation and comparative tables must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Arm harm collection, observation windows, cointerventions, discontinuation and comparative tables with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N39 · Are event counts and exposure denominators available for harm frequencies?

Current findings: There are 91 randomized, 68 completed and original 23 withdrawals/25.3% attrition. Harm counts, exposure/observation denominators and discontinuation reasons are separately unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Harm counts, exposure/observation denominators and discontinuation reasons are needed.
Required materials and conditions: Actual exposure, observation/analysis n, attrition, harm counts and observation windows
Materials to obtain first: Harm counts, exposure/observation denominators and discontinuation reasons are needed.
Further research: Material needed: Harm counts, exposure/observation denominators and discontinuation reasons are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Actual exposure, observation/analysis n, attrition, harm counts and observation windows must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Actual exposure, observation/analysis n, attrition, harm counts and observation windows with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N40 · Are medication, lifestyle care and other exposures separated from harm causes?

Current findings: Original context is an adjunct with medication/lifestyle management continued. Actual harm relationships with other diseases/treatments, causality judgments and timing are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Concurrent factors, actual events, causality judgments and timing are needed.
Required materials and conditions: Concurrent medication/lifestyle care, baseline disease, attrition and event sequence
Materials to obtain first: Concurrent factors, actual events, causality judgments and timing are needed.
Further research: Material needed: Concurrent factors, actual events, causality judgments and timing are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Concurrent medication/lifestyle care, baseline disease, attrition and event sequence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Concurrent medication/lifestyle care, baseline disease, attrition and event sequence with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N41 · How do completion/attrition differ from missing harm reports?

Current findings: High attrition and complete-case analysis appear in original records. Discontinuation because of harm, omitted symptom reports and later follow-up collection are unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Harm-related discontinuation, missing data, selective reporting and later follow-up are needed.
Required materials and conditions: Attrition/discontinuation reasons, missing symptoms, selective reporting and follow-up
Materials to obtain first: Harm-related discontinuation, missing data, selective reporting and later follow-up are needed.
Further research: Material needed: Harm-related discontinuation, missing data, selective reporting and later follow-up are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Attrition/discontinuation reasons, missing symptoms, selective reporting and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Attrition/discontinuation reasons, missing symptoms, selective reporting and follow-up with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N42 · What is known about independent, vulnerable-population and later harms?

Current findings: Stored scope is a short adjunctive SBP trial and an indirect acute HRV report. Independent harms under the same exposure, vulnerable groups and events after 6 weeks are unverified; no new search was done.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Independent harm, vulnerable-population and later follow-up materials are needed.
Required materials and conditions: Matching combined exposure, independent reports, vulnerable groups and later harms
Materials to obtain first: Independent harm, vulnerable-population and later follow-up materials are needed.
Further research: Material needed: Independent harm, vulnerable-population and later follow-up materials are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Matching combined exposure, independent reports, vulnerable groups and later harms must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Matching combined exposure, independent reports, vulnerable groups and later harms with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N43 · How do method copies, frozen conditions, application and content review differ?

Current findings: Preserved copies of 5 method HTML files, applied conditions and the review contract are linked. Condition freezing and observation application are separate; creation and existing production-wording correction histories are preserved. Content/claim-boundary review remains incomplete.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: This does not indicate completed content review or new official-method/clinical certification.
Required materials and conditions: Method copies, applied conditions, originals, versions and creation/application history
Materials to obtain first: This does not indicate completed content review or new official-method/clinical certification.
Further research: Material needed: This does not indicate completed content review or new official-method/clinical certification. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Method copies, applied conditions, originals, versions and creation/application history must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Method copies, applied conditions, originals, versions and creation/application history with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources