# Combined breathing added to standard care × six-week SBP: evidence checklist Verdict 3001 · Evidence Check Stored-material review date: Not recorded Original evidence cut-off: 2026-09-07 Review-criteria version: 1.1 Public page/material preparation date: 2026-10-18 Clinical papers were not read directly; existing review summaries were checked. No new clinical-literature search was performed. Unverified does not mean that research is absent or that there is no effect. ## Assessment scope - Population: Adults with hypertension continued medication and lifestyle management. Mittal has 91 randomized and 68 completed; preserve original 23 withdrawals and 25.3% attrition. Age, baseline pressure, comorbidities and arm allocation/analysis denominators are unverified. Ghiya has a separate 100-participant acute HRV report. - Ingredient, formulation and route: The study added a combined alternate-nostril breathing program preceded by abdominal breathing to standard care. This is not converted into standalone alternate-nostril, other pranayama or combined-yoga effects. Component contributions, actual delivery, instruction and adherence are unverified. - Dose: Original study identifiers are 2 minutes of abdominal breathing followed by 10 minutes of alternate-nostril breathing, 12 minutes daily for 6 weeks. Actual exposure, adherence and discontinuation are unverified. This plan is not turned into personal breathing procedures, medication reduction/replacement or treatment instructions. - Comparator: Combined breathing added to standard management versus standard management alone. Actual medication types, doses, changes, lifestyle care and contact/attention controls are unverified. Ghiya's other-pranayama comparator is a separate acute HRV context. - Measured outcome: The selection is final 6-week SBP: breathing 139.14±12.5 versus control 147.79±12.8 mmHg, between-group P<.01. The meaning of ±, denominators, adjusted between-group effects and 95% CIs are unverified. Crude final-value difference -8.65 mmHg is an existing record, not adjusted change, ITT or a personal effect. DBP P>.05 and HRV are separate. - Duration: Direct SBP context spans 6 weeks; Ghiya is an acute HRV comparison. Post-training persistence, harm follow-up, medication changes and long-term clinical events are unverified. Short-term final values are not extended into long-term effects or treatment replacement. - Questions outside this scope: Transferring final values, crude differences, P or ± into baseline-adjusted effects, 95% CIs, ITT or personal effects; Extending the combined abdominal-first adjunct into standalone alternate-nostril breathing, other yoga or medication replacement; Counting DBP, acute HRV or multiple measures from one report as independent 6-week SBP replication; Turning randomized, completed, withdrawn or other-report participants into unique-participant totals or new calculations; Turning the CTRI identifier into NCT, verified prospective endpoints or reading registration originals; Using public/academic support, original C with 50 points or caution as new independence, precision or safety certification; Creating new numbers, grades, breathing procedures, medication reduction/replacement or treatment instructions ## Checklist items ### N01 · Which 6-week SBP question is selected? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The selected wording is lower 6-week SBP added to standard care. The parent verdict concerns 6-week systolic pressure in treated adults with hypertension; another subclaim concerns DBP/HRV. Preserve the existing selected question without counting new independent replication. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Detailed prospective analyses and endpoint hierarchy for the selected question are unverified. - Required materials and conditions: Adjunct 6-week SBP claim and boundaries of other outcomes - Materials to obtain first: Detailed prospective analyses and endpoint hierarchy for the selected question are unverified. - Further research: Material needed: Detailed prospective analyses and endpoint hierarchy for the selected question are unverified. This records needed materials; no new research was executed. - Conditions for verification: Material for Adjunct 6-week SBP claim and boundaries of other outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Adjunct 6-week SBP claim and boundaries of other outcomes with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N02 · How are selected grade and parent score distinguished? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Selected original grade is C, with a note that final values differed but adjusted effect/CI were unverified. Selected-question score/status are unrecorded. Parent C with 50 points and caution are historical context, not a new subclaim score. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Selected-question score/status fields are unrecorded. - Required materials and conditions: Selected C, original note, absent score/status and parent C with 50 points - Materials to obtain first: Selected-question score/status fields are unrecorded. - Further research: Material needed: Selected-question score/status fields are unrecorded. This records needed materials; no new research was executed. - Conditions for verification: Material for Selected C, original note, absent score/status and parent C with 50 points must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Selected C, original note, absent score/status and parent C with 50 points with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: ### N03 · Which adults with hypertension do the 6-week results concern? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original descriptions concern adults with hypertension continuing medication and lifestyle management. Age, baseline SBP, severity, comorbidities, eligibility, exclusions and recruitment characteristics are unverified in the stored summary. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Detailed eligibility, baseline risk, recruitment and comorbidity materials are needed. - Required materials and conditions: Treated participants, eligibility, baseline pressure, severity and comorbidities - Materials to obtain first: Detailed eligibility, baseline risk, recruitment and comorbidity materials are needed. - Further research: Material needed: Detailed eligibility, baseline risk, recruitment and comorbidity materials are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Treated participants, eligibility, baseline pressure, severity and comorbidities must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Treated participants, eligibility, baseline pressure, severity and comorbidities with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N04 · How does the combined intervention differ from alternate-nostril breathing alone? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The original study describes 2 minutes of abdominal breathing followed by 10 minutes of Nadi Shodhana, explicitly not alternate-nostril breathing alone. Component-specific SBP contributions and direct standalone comparisons are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Component contributions and direct standalone alternate-nostril comparisons are needed. - Required materials and conditions: Abdominal breathing for 2 minutes before 10 minutes of alternate-nostril breathing - Materials to obtain first: Component contributions and direct standalone alternate-nostril comparisons are needed. - Further research: Material needed: Component contributions and direct standalone alternate-nostril comparisons are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Abdominal breathing for 2 minutes before 10 minutes of alternate-nostril breathing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Abdominal breathing for 2 minutes before 10 minutes of alternate-nostril breathing with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N05 · What original information describes daily exposure and duration? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original records describe adding 12 minutes daily for 6 weeks; the first 2 of 12 minutes were abdominal breathing. Actual days, frequency, adherence, discontinuation and exposure-specific SBP responses are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Actual adherence, discontinuation, exposure records and exposure-specific effects are needed. - Required materials and conditions: Daily 12-minute, 6-week plan versus actual adherence, discontinuation and assessment - Materials to obtain first: Actual adherence, discontinuation, exposure records and exposure-specific effects are needed. - Further research: Material needed: Actual adherence, discontinuation, exposure records and exposure-specific effects are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Daily 12-minute, 6-week plan versus actual adherence, discontinuation and assessment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Daily 12-minute, 6-week plan versus actual adherence, discontinuation and assessment with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N06 · How does addition to standard care differ from standalone treatment? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Standard management plus breathing versus standard management alone. Original records say medication/lifestyle care continued. Medication types, doses, lifestyle-management details and changes are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Arm-specific medication/lifestyle details, changes, common care and attention controls are needed. - Required materials and conditions: Continued medication/lifestyle care and the combined-breathing comparison - Materials to obtain first: Arm-specific medication/lifestyle details, changes, common care and attention controls are needed. - Further research: Material needed: Arm-specific medication/lifestyle details, changes, common care and attention controls are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Continued medication/lifestyle care and the combined-breathing comparison must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Continued medication/lifestyle care and the combined-breathing comparison with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N07 · How do final 6-week SBP values differ from changes? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original endpoints are 6-week SBP, DBP and HRV over 6 weeks. The selection is SBP; original reader-answer values are final arm values after 6 weeks. Changes, adjustments and measurement details are separately unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Baseline, change, exact measurement and adjustment-model materials are needed. - Required materials and conditions: SBP definition, units, final values, baseline, change and measurement - Materials to obtain first: Baseline, change, exact measurement and adjustment-model materials are needed. - Further research: Material needed: Baseline, change, exact measurement and adjustment-model materials are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for SBP definition, units, final values, baseline, change and measurement must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects SBP definition, units, final values, baseline, change and measurement with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N08 · What are the stored arm-specific final 6-week SBP statistics? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original records give breathing 139.14±12.5 and control 147.79±12.8 mmHg, between-group P<.01. The evidence summary preserves the same result. The meaning of ±, exact arm analysis n and CIs are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: The meaning of ±, arm analysis n, CIs and test/model details are needed. - Required materials and conditions: 139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and arm identity - Materials to obtain first: The meaning of ±, arm analysis n, CIs and test/model details are needed. - Further research: Material needed: The meaning of ±, arm analysis n, CIs and test/model details are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for 139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and arm identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects 139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and arm identity with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N09 · What does -8.65 mmHg represent? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Existing Korean/English records say the crude final-value difference -8.65 mmHg should not be called baseline-adjusted change. This value comes from original records; it was not newly calculated here. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Exact CIs, denominators and models for the crude difference are unverified. - Required materials and conditions: Original crude final-value difference versus baseline-adjusted effect - Materials to obtain first: Exact CIs, denominators and models for the crude difference are unverified. - Further research: Material needed: Exact CIs, denominators and models for the crude difference are unverified. This records needed materials; no new research was executed. - Conditions for verification: Material for Original crude final-value difference versus baseline-adjusted effect must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Original crude final-value difference versus baseline-adjusted effect with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N10 · Are baseline-adjusted between-group effects and 95% CIs verified? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original notes/descriptions explicitly leave adjusted between-group effects and 95% CIs unverified. Crude difference -8.65 or between-group P<.01 does not replace them. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Adjusted effects, 95% CIs, baseline, covariates and analysis models are needed. - Required materials and conditions: Baseline, covariates, adjustment model, between-group effect and 95% CIs - Materials to obtain first: Adjusted effects, 95% CIs, baseline, covariates and analysis models are needed. - Further research: Material needed: Adjusted effects, 95% CIs, baseline, covariates and analysis models are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Baseline, covariates, adjustment model, between-group effect and 95% CIs must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Baseline, covariates, adjustment model, between-group effect and 95% CIs with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N11 · How do P values differ from effect size and precision? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Final-SBP between-group P<.01 is preserved. The 95% CI, precise adjusted effect, prospective target and sample-size rationale are unverified; parent precision is unrecorded. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Effect intervals, clinical thresholds, prospective plans and sample-size calculations are needed. - Required materials and conditions: SBP effects, CIs, clinical importance, sample-size plans and denominators - Materials to obtain first: Effect intervals, clinical thresholds, prospective plans and sample-size calculations are needed. - Further research: Material needed: Effect intervals, clinical thresholds, prospective plans and sample-size calculations are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for SBP effects, CIs, clinical importance, sample-size plans and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects SBP effects, CIs, clinical importance, sample-size plans and denominators with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N12 · What stage does 91 randomized describe? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Mittal is stored as 91 randomized and 68 completed. Arm allocation n, eligibility, exclusions and recruitment flow are unverified in the summary. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Arm allocation, recruitment, eligibility and exclusion counts are needed. - Required materials and conditions: Original allocation of 91 and arm allocation/recruitment/eligibility flow - Materials to obtain first: Arm allocation, recruitment, eligibility and exclusion counts are needed. - Further research: Material needed: Arm allocation, recruitment, eligibility and exclusion counts are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Original allocation of 91 and arm allocation/recruitment/eligibility flow must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Original allocation of 91 and arm allocation/recruitment/eligibility flow with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N13 · How do completion and 6-week analyses connect? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original descriptions concern a complete-case analysis after 23 withdrawals. The 68 completed is original n; exact arm-specific 6-week SBP analysis n, DBP/HRV missingness and denominator identity are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Arm completion/analysis n, endpoint-specific missingness and complete-case definitions are needed. - Required materials and conditions: 68 completed, arm completion, endpoint analysis n and complete-case definition - Materials to obtain first: Arm completion/analysis n, endpoint-specific missingness and complete-case definitions are needed. - Further research: Material needed: Arm completion/analysis n, endpoint-specific missingness and complete-case definitions are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for 68 completed, arm completion, endpoint analysis n and complete-case definition must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects 68 completed, arm completion, endpoint analysis n and complete-case definition with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N14 · What original records describe 23 withdrawals and 25.3% attrition? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original records describe 25.3% attrition and complete-case analysis after 23 withdrawals. These are existing figures, not new calculations. Arm distribution, reasons, baseline differences and timing are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Arm attrition, reasons, timing and withdrawn participants' baseline/outcome data are needed. - Required materials and conditions: Attrition, arm reasons, timing, baseline risk and data loss - Materials to obtain first: Arm attrition, reasons, timing and withdrawn participants' baseline/outcome data are needed. - Further research: Material needed: Arm attrition, reasons, timing and withdrawn participants' baseline/outcome data are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Attrition, arm reasons, timing, baseline risk and data loss must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Attrition, arm reasons, timing, baseline risk and data loss with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N15 · Which intervention effect does the complete-case result estimate? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original records identify complete-case analysis and high attrition as limitations. ITT estimates for all 91 participants, imputation, sensitivity, actual-use and adjusted analyses are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: ITT/PP, missingness handling, sensitivity, effects of interest and original models are needed. - Required materials and conditions: ITT, PP, complete cases, missingness, medication, adherence and sensitivity - Materials to obtain first: ITT/PP, missingness handling, sensitivity, effects of interest and original models are needed. - Further research: Material needed: ITT/PP, missingness handling, sensitivity, effects of interest and original models are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for ITT, PP, complete cases, missingness, medication, adherence and sensitivity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects ITT, PP, complete cases, missingness, medication, adherence and sensitivity with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N16 · What is known about allocation, concealment and recruitment? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Mittal is stored as a randomized adjunct-to-standard-management trial. Actual generation, concealment, recruitment order, baseline balance and analysis procedures are unverified in the summary. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Allocation generation, concealment, recruitment and baseline-balance procedures are needed. - Required materials and conditions: Random-sequence generation, concealment, recruitment order, baseline and assessment - Materials to obtain first: Allocation generation, concealment, recruitment and baseline-balance procedures are needed. - Further research: Material needed: Allocation generation, concealment, recruitment and baseline-balance procedures are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Random-sequence generation, concealment, recruitment order, baseline and assessment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Random-sequence generation, concealment, recruitment order, baseline and assessment with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N17 · Are participant, instructor and assessor awareness/contact known? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The original comparison is added breathing versus standard management. Contact time, control activities, assessor/analyst allocation awareness and actual blinding procedures are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Attention/contact controls, instructors and measurement/analysis blinding materials are needed. - Required materials and conditions: Attention/time controls, instruction, contact and measurement/analysis blinding - Materials to obtain first: Attention/contact controls, instructors and measurement/analysis blinding materials are needed. - Further research: Material needed: Attention/contact controls, instructors and measurement/analysis blinding materials are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Attention/time controls, instruction, contact and measurement/analysis blinding must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Attention/time controls, instruction, contact and measurement/analysis blinding with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N18 · Can baseline pressure and arm differences be linked to final values? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original records do not call the -8.65 final-value difference baseline-adjusted change. Exact arm baseline SBP, changes, covariates and adjustment details are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Baseline SBP/DBP, medication/risk balance and model handling are needed. - Required materials and conditions: Arm baseline SBP/DBP, medication, risk and baseline handling - Materials to obtain first: Baseline SBP/DBP, medication/risk balance and model handling are needed. - Further research: Material needed: Baseline SBP/DBP, medication/risk balance and model handling are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Arm baseline SBP/DBP, medication, risk and baseline handling must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Arm baseline SBP/DBP, medication, risk and baseline handling with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N19 · How was 6-week SBP measured? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original wording describes 6-week systolic pressure in mmHg. Exact devices, office/home/ambulatory pressure, repeat averages, rest, timing and assessor methods are unverified in the summary. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Measurement devices, settings, repetitions, rest, timing and assessors are needed. - Required materials and conditions: Device, posture, rest, repetitions, setting, time and assessors - Materials to obtain first: Measurement devices, settings, repetitions, rest, timing and assessors are needed. - Further research: Material needed: Measurement devices, settings, repetitions, rest, timing and assessors are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Device, posture, rest, repetitions, setting, time and assessors must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Device, posture, rest, repetitions, setting, time and assessors with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N20 · How does continued medication differ from actual prescription changes? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original records describe an adjunct with medication/lifestyle management continued. Arm medication types, doses, adherence, changes, rescue prescriptions and handling in SBP analyses are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Actual medication, doses, adherence, changes and model handling are needed. - Required materials and conditions: Arm medication types, doses, changes, adherence, rescue drugs and timing - Materials to obtain first: Actual medication, doses, adherence, changes and model handling are needed. - Further research: Material needed: Actual medication, doses, adherence, changes and model handling are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Arm medication types, doses, changes, adherence, rescue drugs and timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Arm medication types, doses, changes, adherence, rescue drugs and timing with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N21 · Are lifestyle care and other breathing/yoga comparisons distinguished? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original descriptions say other pranayama or combined-yoga results were not used. Specific standard lifestyle care and changes are unverified; Ghiya's other-breathing comparison is a separate acute HRV context. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Lifestyle content, arm changes and adherence to other interventions are needed. - Required materials and conditions: Standard lifestyle management, exercise, diet, contact and other-intervention boundaries - Materials to obtain first: Lifestyle content, arm changes and adherence to other interventions are needed. - Further research: Material needed: Lifestyle content, arm changes and adherence to other interventions are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Standard lifestyle management, exercise, diet, contact and other-intervention boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Standard lifestyle management, exercise, diet, contact and other-intervention boundaries with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02 ### N22 · Are actual breathing exposure and discontinuation linked to analyses? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve the original daily 6-week plan, 91 allocated and 68 completed. Actual adherence, instruction, discontinuation reasons and completion-exposure relationships are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Adherence, actual exposure, discontinuation reasons and attrition relationships are needed. - Required materials and conditions: Actual delivery, instruction, adherence, discontinuation, exposure/completion denominators and analysis - Materials to obtain first: Adherence, actual exposure, discontinuation reasons and attrition relationships are needed. - Further research: Material needed: Adherence, actual exposure, discontinuation reasons and attrition relationships are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Actual delivery, instruction, adherence, discontinuation, exposure/completion denominators and analysis must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Actual delivery, instruction, adherence, discontinuation, exposure/completion denominators and analysis with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N23 · Is the CTRI identifier separate from a prospective SBP plan? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Mittal's original registration wording is CTRI/2023/11/059625. Original descriptions explicitly leave official prospective endpoints unverified. Listing SBP, DBP and HRV does not establish prospective hierarchy. Registration contents, dates and changes were unread this time. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Registration contents, prospective endpoints, recruitment/registration dates and plan amendments are needed. - Required materials and conditions: CTRI/2023/11/059625, registration, plans, endpoint hierarchy and timing - Materials to obtain first: Registration contents, prospective endpoints, recruitment/registration dates and plan amendments are needed. - Further research: Material needed: Registration contents, prospective endpoints, recruitment/registration dates and plan amendments are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for CTRI/2023/11/059625, registration, plans, endpoint hierarchy and timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects CTRI/2023/11/059625, registration, plans, endpoint hierarchy and timing with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N24 · How is the null DBP wording preserved? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Mittal's original results are between-group SBP P<.01 and DBP P>.05. Parent descriptions call DBP null; the other subclaim's original grade is D. Distinguish selected SBP C and retain unverified exact DBP effects/CIs. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Exact DBP values, arm denominators, effects, CIs and plans are needed. - Required materials and conditions: Between-group DBP P>.05 versus SBP, effects, CIs and denominators - Materials to obtain first: Exact DBP values, arm denominators, effects, CIs and plans are needed. - Further research: Material needed: Exact DBP values, arm denominators, effects, CIs and plans are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Between-group DBP P>.05 versus SBP, effects, CIs and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Between-group DBP P>.05 versus SBP, effects, CIs and denominators with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N25 · How does 6-week SBP differ from main-trial HRV? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original descriptions say HRV varied by measure. Endpoints are 6-week SBP, DBP and HRV; the other subclaim note also says HRV varied by measure/study. Specific measures, effects, CIs and analyses are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: HRV measures, units, effects, CIs, timing and denominators are needed. - Required materials and conditions: Mittal HRV measures, units, timing and analyses versus SBP - Materials to obtain first: HRV measures, units, effects, CIs, timing and denominators are needed. - Further research: Material needed: HRV measures, units, effects, CIs, timing and denominators are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Mittal HRV measures, units, timing and analyses versus SBP must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Mittal HRV measures, units, timing and analyses versus SBP with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N26 · Is the 100-participant HRV comparison direct 6-week SBP evidence? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Ghiya is stored as 100 participants, an acute comparison with another pranayama and null between-group HRV. Original records describe indirect HRV context; the citation note says it is not 6-week pressure replication. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Exact acute HRV measures, effects, CIs, population, denominators and registration are needed. - Required materials and conditions: Ghiya's other-pranayama acute HRV comparison, original null result and identity - Materials to obtain first: Exact acute HRV measures, effects, CIs, population, denominators and registration are needed. - Further research: Material needed: Exact acute HRV measures, effects, CIs, population, denominators and registration are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Ghiya's other-pranayama acute HRV comparison, original null result and identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Ghiya's other-pranayama acute HRV comparison, original null result and identity with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R02 ### N27 · How are reports, populations and endpoints kept from double-counting? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Mittal SBP, DBP and HRV are measures from one stored report. Ghiya is another comparator/acute HRV report. Preserve identities without calculating or establishing unique-trial/participant totals or independent 6-week SBP replication counts. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Report/cohort overlap, registration links and unique-participant/trial counts are unverified. - Required materials and conditions: Mittal/Ghiya bibliographies, registration and report/trial/cohort links - Materials to obtain first: Report/cohort overlap, registration links and unique-participant/trial counts are unverified. - Further research: Material needed: Report/cohort overlap, registration links and unique-participant/trial counts are unverified. This records needed materials; no new research was executed. - Conditions for verification: Material for Mittal/Ghiya bibliographies, registration and report/trial/cohort links must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Mittal/Ghiya bibliographies, registration and report/trial/cohort links with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02 ### N28 · What is the verification level of public/academic support wording? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Mittal is stored as reported public/academic support; Ghiya as academic research. Specific institutions, amounts, design/analysis involvement, COI, instructor/assessor roles and report independence are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Support/COI details, involvement, researcher roles and independence materials are needed. - Required materials and conditions: Report-specific support, COI, roles and independence - Materials to obtain first: Support/COI details, involvement, researcher roles and independence materials are needed. - Further research: Material needed: Support/COI details, involvement, researcher roles and independence materials are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Report-specific support, COI, roles and independence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Report-specific support, COI, roles and independence with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02 ### N29 · Is independent SBP evidence available for the same population, components and duration? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original grading describes a short-term SBP signal and says acute HRV was not counted as independent 6-week pressure replication. Independent direct SBP materials matching components, population and duration are unverified within the stored scope. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Independent direct evidence for the same question, condition differences and report-family relationships are needed. - Required materials and conditions: Direct follow-up with matching combined adjunct, population, measurements and denominators - Materials to obtain first: Independent direct evidence for the same question, condition differences and report-family relationships are needed. - Further research: Material needed: Independent direct evidence for the same question, condition differences and report-family relationships are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Direct follow-up with matching combined adjunct, population, measurements and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Direct follow-up with matching combined adjunct, population, measurements and denominators with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02 ### N30 · Does the 6-week effect persist after the program ends? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The original verdict identifies short follow-up as a limitation. Post-program pressure, continued/discontinued practice, medication/lifestyle changes and persistence are unverified in the stored summary. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Post-program follow-up, exposure/treatment changes and sustained SBP materials are needed. - Required materials and conditions: Post-program follow-up, medication, lifestyle care, continuation/discontinuation and pressure - Materials to obtain first: Post-program follow-up, exposure/treatment changes and sustained SBP materials are needed. - Further research: Material needed: Post-program follow-up, exposure/treatment changes and sustained SBP materials are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Post-program follow-up, medication, lifestyle care, continuation/discontinuation and pressure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Post-program follow-up, medication, lifestyle care, continuation/discontinuation and pressure with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N31 · Does a final-SBP signal answer cardiovascular-event or medication-replacement questions? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original summaries say this is not evidence of a standalone effect or medication replacement. Short-term final values are not extended into treatment replacement or long-term events. Direct cardiovascular-event/medication-reduction effects are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Direct long-term clinical-event, medication-change and replacement materials are needed. - Required materials and conditions: Pressure surrogates versus separate clinical-event/medication-change comparisons - Materials to obtain first: Direct long-term clinical-event, medication-change and replacement materials are needed. - Further research: Material needed: Direct long-term clinical-event, medication-change and replacement materials are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Pressure surrogates versus separate clinical-event/medication-change comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Pressure surrogates versus separate clinical-event/medication-change comparisons with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N32 · What level of material was actually read? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The complete stored parent-verdict summary was read and a copy preserved. Mittal/Ghiya bibliographies and report summaries were read; external abstracts, full texts, registration, plans and support materials were unread, with access unattempted. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: External materials were unread; inaccessibility or access failure was not verified either. - Required materials and conditions: Stored summaries/bibliographies versus external abstracts, full texts, registration and plans - Materials to obtain first: External materials were unread; inaccessibility or access failure was not verified either. - Further research: Material needed: External materials were unread; inaccessibility or access failure was not verified either. This records needed materials; no new research was executed. - Conditions for verification: Material for Stored summaries/bibliographies versus external abstracts, full texts, registration and plans must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Stored summaries/bibliographies versus external abstracts, full texts, registration and plans with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02 ### N33 · How are the original date, production and review separated? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The original evidence date is 2026-09-07; corrections are an empty array and deliberation an empty string. Cross-check applied in the parent verdict is a historical record, not completion of current review. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Current content-review and new clinical-verification dates are undetermined. - Required materials and conditions: Original evidence date, empty correction/deliberation records and historical grade decisions - Materials to obtain first: Current content-review and new clinical-verification dates are undetermined. - Further research: Material needed: Current content-review and new clinical-verification dates are undetermined. This records needed materials; no new research was executed. - Conditions for verification: Material for Original evidence date, empty correction/deliberation records and historical grade decisions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Original evidence date, empty correction/deliberation records and historical grade decisions with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: ### N34 · Are both original languages' boundaries preserved? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Selected English wording concerns 6-week SBP added to standard care; its note separates final-value differences from unverified adjusted effects/CIs. Parent English describes combined breathing, addition to medication/lifestyle care, 25.3% attrition and crude-difference boundaries. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Detailed comparison of external papers, Korean/English translations and corrections is unverified. - Required materials and conditions: Selected claims/notes and combined adjunct, final-value, adjustment and attrition boundaries - Materials to obtain first: Detailed comparison of external papers, Korean/English translations and corrections is unverified. - Further research: Material needed: Detailed comparison of external papers, Korean/English translations and corrections is unverified. This records needed materials; no new research was executed. - Conditions for verification: Material for Selected claims/notes and combined adjunct, final-value, adjustment and attrition boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Selected claims/notes and combined adjunct, final-value, adjustment and attrition boundaries with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: ### N35 · How are parent axes and absent selected-question fields preserved? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Parent axes are B/S/R1/I2/EX/B2, with precision unrecorded. Coprimary split, large hard-outcome trial, no human study and 1st-endpoint failure followed by a positive 2nd endpoint are all false; derived grade is C and override reasons are empty strings. The selected question has no separate score/status/axes. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Preserve absent selected score/status/axes and unverified precision. - Required materials and conditions: B/S/R1/I2/EX/B2, unrecorded precision, original booleans and empty overrides - Materials to obtain first: Preserve absent selected score/status/axes and unverified precision. - Further research: Material needed: Preserve absent selected score/status/axes and unverified precision. This records needed materials; no new research was executed. - Conditions for verification: Material for B/S/R1/I2/EX/B2, unrecorded precision, original booleans and empty overrides must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects B/S/R1/I2/EX/B2, unrecorded precision, original booleans and empty overrides with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: ### N36 · How were harms defined and collected? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original safety is caution, with warnings about hyperventilation, dizziness and distress. Actual counts, active/passive collection, assessors and original harm tables are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Harm definitions, collection procedures, assessors and actual event tables are needed. - Required materials and conditions: Original hyperventilation, dizziness and distress warnings versus actual events - Materials to obtain first: Harm definitions, collection procedures, assessors and actual event tables are needed. - Further research: Material needed: Harm definitions, collection procedures, assessors and actual event tables are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Original hyperventilation, dizziness and distress warnings versus actual events must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Original hyperventilation, dizziness and distress warnings versus actual events with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N37 · Are exposure, discontinuation, symptoms and follow-up timing known? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The daily 6-week exposure plan is preserved. Symptom onset, discontinuation timing, recurrence, recovery and later harm follow-up are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Harm timing, recurrence, recovery and later follow-up are needed. - Required materials and conditions: Actual exposure, symptom/discontinuation timing and during/post-study follow-up - Materials to obtain first: Harm timing, recurrence, recovery and later follow-up are needed. - Further research: Material needed: Harm timing, recurrence, recovery and later follow-up are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Actual exposure, symptom/discontinuation timing and during/post-study follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Actual exposure, symptom/discontinuation timing and during/post-study follow-up with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N38 · Were harms compared with standard care using the same methods? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The adjunct-to-standard-care comparison is preserved. Matching arm harm collection, observation periods and comparative event results are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Comparative harms, matching collection/follow-up and original tables are needed. - Required materials and conditions: Arm harm collection, observation windows, cointerventions, discontinuation and comparative tables - Materials to obtain first: Comparative harms, matching collection/follow-up and original tables are needed. - Further research: Material needed: Comparative harms, matching collection/follow-up and original tables are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Arm harm collection, observation windows, cointerventions, discontinuation and comparative tables must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Arm harm collection, observation windows, cointerventions, discontinuation and comparative tables with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N39 · Are event counts and exposure denominators available for harm frequencies? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: There are 91 randomized, 68 completed and original 23 withdrawals/25.3% attrition. Harm counts, exposure/observation denominators and discontinuation reasons are separately unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Harm counts, exposure/observation denominators and discontinuation reasons are needed. - Required materials and conditions: Actual exposure, observation/analysis n, attrition, harm counts and observation windows - Materials to obtain first: Harm counts, exposure/observation denominators and discontinuation reasons are needed. - Further research: Material needed: Harm counts, exposure/observation denominators and discontinuation reasons are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Actual exposure, observation/analysis n, attrition, harm counts and observation windows must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Actual exposure, observation/analysis n, attrition, harm counts and observation windows with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N40 · Are medication, lifestyle care and other exposures separated from harm causes? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original context is an adjunct with medication/lifestyle management continued. Actual harm relationships with other diseases/treatments, causality judgments and timing are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Concurrent factors, actual events, causality judgments and timing are needed. - Required materials and conditions: Concurrent medication/lifestyle care, baseline disease, attrition and event sequence - Materials to obtain first: Concurrent factors, actual events, causality judgments and timing are needed. - Further research: Material needed: Concurrent factors, actual events, causality judgments and timing are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Concurrent medication/lifestyle care, baseline disease, attrition and event sequence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Concurrent medication/lifestyle care, baseline disease, attrition and event sequence with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N41 · How do completion/attrition differ from missing harm reports? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: High attrition and complete-case analysis appear in original records. Discontinuation because of harm, omitted symptom reports and later follow-up collection are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Harm-related discontinuation, missing data, selective reporting and later follow-up are needed. - Required materials and conditions: Attrition/discontinuation reasons, missing symptoms, selective reporting and follow-up - Materials to obtain first: Harm-related discontinuation, missing data, selective reporting and later follow-up are needed. - Further research: Material needed: Harm-related discontinuation, missing data, selective reporting and later follow-up are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Attrition/discontinuation reasons, missing symptoms, selective reporting and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Attrition/discontinuation reasons, missing symptoms, selective reporting and follow-up with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N42 · What is known about independent, vulnerable-population and later harms? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Stored scope is a short adjunctive SBP trial and an indirect acute HRV report. Independent harms under the same exposure, vulnerable groups and events after 6 weeks are unverified; no new search was done. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Independent harm, vulnerable-population and later follow-up materials are needed. - Required materials and conditions: Matching combined exposure, independent reports, vulnerable groups and later harms - Materials to obtain first: Independent harm, vulnerable-population and later follow-up materials are needed. - Further research: Material needed: Independent harm, vulnerable-population and later follow-up materials are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Matching combined exposure, independent reports, vulnerable groups and later harms must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Matching combined exposure, independent reports, vulnerable groups and later harms with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02 ### N43 · How do method copies, frozen conditions, application and content review differ? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserved copies of 5 method HTML files, applied conditions and the review contract are linked. Condition freezing and observation application are separate; creation and existing production-wording correction histories are preserved. Content/claim-boundary review remains incomplete. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: This does not indicate completed content review or new official-method/clinical certification. - Required materials and conditions: Method copies, applied conditions, originals, versions and creation/application history - Materials to obtain first: This does not indicate completed content review or new official-method/clinical certification. - Further research: Material needed: This does not indicate completed content review or new official-method/clinical certification. This records needed materials; no new research was executed. - Conditions for verification: Material for Method copies, applied conditions, originals, versions and creation/application history must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Method copies, applied conditions, originals, versions and creation/application history with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries. - Application exceptions: Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: ## Evidence and sources ### R01 Mittal G, et al. An Exploratory Randomised Trial to Assess the Effect of Nadi Shodhan Pranayama as an Adjunct Versus Standard Non-pharmacological Management in Hypertensives. Ann Neurosci. 2025. PMID: 40242728. PMCID: PMC11996816. DOI: 10.1177/09727531251318810. [PubMed](https://pubmed.ncbi.nlm.nih.gov/40242728/) Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread Findings recorded in the summary: SBP 139.14±12.5 vs 147.79±12.8, P<.01; DBP P>.05 Record level: Complete-case final values from the direct combined 6-week SBP adjunct. Preserve 91 randomized, 68 completed and original 23 withdrawals/25.3% attrition. Crude final-value difference -8.65 mmHg is not adjusted change or ITT; the meaning of ±, exact arm denominators and adjusted effects/95% CIs are unverified. Independent replication: Mittal SBP, DBP and HRV are measures from one stored report; Ghiya compares acute HRV with another pranayama. Report/cohort relationships and unique-trial/participant totals are unverified. Repeated measures, randomized/completed/withdrawn participants and other questions are not counted as new independent SBP trials or participant totals. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading. | | External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading. | | External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading. | | Protocol | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading. | | Analysis plan and original tables | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading. | | Intervention and harms | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading. | | Support and interests | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading. | ### R02 Ghiya S, et al. Comparison of the effects of Nadi Shodhana Pranayama and Bhramari Pranayama on heart rate variability. J Ayurveda Integr Med. 2023. PMID: 37499590. PMCID: PMC10388195. DOI: 10.1016/j.jaim.2023.100774. [PubMed](https://pubmed.ncbi.nlm.nih.gov/37499590/) Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread Findings recorded in the summary: Between-group HRV was null Record level: Separate 100-participant acute HRV comparison with another pranayama; preserve the original between-group null result. This is not independent 6-week SBP replication; population, arm denominators, measure-specific effects/CIs and report-family relationships are unverified. Independent replication: Mittal SBP, DBP and HRV are measures from one stored report; Ghiya compares acute HRV with another pranayama. Report/cohort relationships and unique-trial/participant totals are unverified. Repeated measures, randomized/completed/withdrawn participants and other questions are not counted as new independent SBP trials or participant totals. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred. | | External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred. | | External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred. | | Protocol | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred. | | Analysis plan and original tables | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred. | | Intervention and harms | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred. | | Support and interests | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred. | ## Review criteria and methods These are Chamgap's own application conditions, informed by the relevant sections of official methodological guidance. They do not constitute official assessment-tool certification or a new efficacy score. - M03 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03) · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13 · Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M04 [Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04) · §4.5, §4.6.1–4.6.3, MECIR C42 · Distinguish studies from reports and link them; do not omit a study solely because results are unreported. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M08 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08) · §8.1–8.2.3, Table 8.2.a · Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M15 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15) · §15.2.4, §15.3.1–15.3.3 · Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M19 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19) · §19.1.2, §19.2.1–19.2.4 · Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. ## What the statuses mean - Met: The original content has been reviewed as meeting the conditions. This status is not used in this preparation. - Partly verified: Some information in the stored summary was linked during preparation; clinical verification or review is not complete. - Unverified: Required direct values, definitions or materials have not been established within the current storage and reading scope. This does not mean zero effect, no papers or failed access. - Review incomplete: Awaiting user review, or actual review remains incomplete. - Not reported: Used only when original materials were actually read and the outcome was judged unreported. Not used for external materials unread in this work. - Inaccessible: Used only when an actual access attempt has a recorded failure. Not used for access that was not attempted in this work. - Insufficient evidence for the conditions: Indicates insufficient direct materials for the relevant scope or conditions; it is not a new grade. - Not applicable: Used when the reason it does not apply to the original question is stated. - Conflicting data: Retains the scope of conflicting statements in original materials; it is not an arbitrary reassessment. ## Change history 2026-10-18 · Public page/materials 1.0. Public pages and materials were prepared from the existing 43 items. No new clinical search, verification-status change or scoring was performed.