{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Combined breathing added to standard care × six-week SBP: evidence checklist",
  "language": "en",
  "translation_date": "2026-10-18",
  "criteria_version": "1.1",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Met": "The original content has been reviewed as meeting the conditions. This status is not used in this preparation.",
    "Partly verified": "Some information in the stored summary was linked during preparation; clinical verification or review is not complete.",
    "Unverified": "Required direct values, definitions or materials have not been established within the current storage and reading scope. This does not mean zero effect, no papers or failed access.",
    "Review incomplete": "Awaiting user review, or actual review remains incomplete.",
    "Not reported": "Used only when original materials were actually read and the outcome was judged unreported. Not used for external materials unread in this work.",
    "Inaccessible": "Used only when an actual access attempt has a recorded failure. Not used for access that was not attempted in this work.",
    "Insufficient evidence for the conditions": "Indicates insufficient direct materials for the relevant scope or conditions; it is not a new grade.",
    "Not applicable": "Used when the reason it does not apply to the original question is stated.",
    "Conflicting data": "Retains the scope of conflicting statements in original materials; it is not an arbitrary reassessment."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which 6-week SBP question is selected?",
      "needed": "Adjunct 6-week SBP claim and boundaries of other outcomes",
      "role": "Required",
      "role_reason": "This condition connects Adjunct 6-week SBP claim and boundaries of other outcomes with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Adjunct 6-week SBP claim and boundaries of other outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Detailed prospective analyses and endpoint hierarchy for the selected question are unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "How are selected grade and parent score distinguished?",
      "needed": "Selected C, original note, absent score/status and parent C with 50 points",
      "role": "Required",
      "role_reason": "This condition connects Selected C, original note, absent score/status and parent C with 50 points with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Selected C, original note, absent score/status and parent C with 50 points must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Selected-question score/status fields are unrecorded. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Which adults with hypertension do the 6-week results concern?",
      "needed": "Treated participants, eligibility, baseline pressure, severity and comorbidities",
      "role": "Required",
      "role_reason": "This condition connects Treated participants, eligibility, baseline pressure, severity and comorbidities with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Treated participants, eligibility, baseline pressure, severity and comorbidities must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Detailed eligibility, baseline risk, recruitment and comorbidity materials are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "How does the combined intervention differ from alternate-nostril breathing alone?",
      "needed": "Abdominal breathing for 2 minutes before 10 minutes of alternate-nostril breathing",
      "role": "Required",
      "role_reason": "This condition connects Abdominal breathing for 2 minutes before 10 minutes of alternate-nostril breathing with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Abdominal breathing for 2 minutes before 10 minutes of alternate-nostril breathing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Component contributions and direct standalone alternate-nostril comparisons are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "What original information describes daily exposure and duration?",
      "needed": "Daily 12-minute, 6-week plan versus actual adherence, discontinuation and assessment",
      "role": "Required",
      "role_reason": "This condition connects Daily 12-minute, 6-week plan versus actual adherence, discontinuation and assessment with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Daily 12-minute, 6-week plan versus actual adherence, discontinuation and assessment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual adherence, discontinuation, exposure records and exposure-specific effects are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "How does addition to standard care differ from standalone treatment?",
      "needed": "Continued medication/lifestyle care and the combined-breathing comparison",
      "role": "Required",
      "role_reason": "This condition connects Continued medication/lifestyle care and the combined-breathing comparison with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Continued medication/lifestyle care and the combined-breathing comparison must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Arm-specific medication/lifestyle details, changes, common care and attention controls are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "How do final 6-week SBP values differ from changes?",
      "needed": "SBP definition, units, final values, baseline, change and measurement",
      "role": "Required",
      "role_reason": "This condition connects SBP definition, units, final values, baseline, change and measurement with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for SBP definition, units, final values, baseline, change and measurement must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Baseline, change, exact measurement and adjustment-model materials are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What are the stored arm-specific final 6-week SBP statistics?",
      "needed": "139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and arm identity",
      "role": "Required",
      "role_reason": "This condition connects 139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and arm identity with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for 139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and arm identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The meaning of ±, arm analysis n, CIs and test/model details are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What does -8.65 mmHg represent?",
      "needed": "Original crude final-value difference versus baseline-adjusted effect",
      "role": "Required",
      "role_reason": "This condition connects Original crude final-value difference versus baseline-adjusted effect with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Original crude final-value difference versus baseline-adjusted effect must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Exact CIs, denominators and models for the crude difference are unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are baseline-adjusted between-group effects and 95% CIs verified?",
      "needed": "Baseline, covariates, adjustment model, between-group effect and 95% CIs",
      "role": "Required",
      "role_reason": "This condition connects Baseline, covariates, adjustment model, between-group effect and 95% CIs with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Baseline, covariates, adjustment model, between-group effect and 95% CIs must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Adjusted effects, 95% CIs, baseline, covariates and analysis models are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "How do P values differ from effect size and precision?",
      "needed": "SBP effects, CIs, clinical importance, sample-size plans and denominators",
      "role": "Required",
      "role_reason": "This condition connects SBP effects, CIs, clinical importance, sample-size plans and denominators with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for SBP effects, CIs, clinical importance, sample-size plans and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Effect intervals, clinical thresholds, prospective plans and sample-size calculations are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "What stage does 91 randomized describe?",
      "needed": "Original allocation of 91 and arm allocation/recruitment/eligibility flow",
      "role": "Required",
      "role_reason": "This condition connects Original allocation of 91 and arm allocation/recruitment/eligibility flow with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Original allocation of 91 and arm allocation/recruitment/eligibility flow must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Arm allocation, recruitment, eligibility and exclusion counts are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "How do completion and 6-week analyses connect?",
      "needed": "68 completed, arm completion, endpoint analysis n and complete-case definition",
      "role": "Required",
      "role_reason": "This condition connects 68 completed, arm completion, endpoint analysis n and complete-case definition with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for 68 completed, arm completion, endpoint analysis n and complete-case definition must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Arm completion/analysis n, endpoint-specific missingness and complete-case definitions are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What original records describe 23 withdrawals and 25.3% attrition?",
      "needed": "Attrition, arm reasons, timing, baseline risk and data loss",
      "role": "Required",
      "role_reason": "This condition connects Attrition, arm reasons, timing, baseline risk and data loss with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Attrition, arm reasons, timing, baseline risk and data loss must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Arm attrition, reasons, timing and withdrawn participants' baseline/outcome data are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Which intervention effect does the complete-case result estimate?",
      "needed": "ITT, PP, complete cases, missingness, medication, adherence and sensitivity",
      "role": "Required",
      "role_reason": "This condition connects ITT, PP, complete cases, missingness, medication, adherence and sensitivity with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for ITT, PP, complete cases, missingness, medication, adherence and sensitivity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: ITT/PP, missingness handling, sensitivity, effects of interest and original models are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "What is known about allocation, concealment and recruitment?",
      "needed": "Random-sequence generation, concealment, recruitment order, baseline and assessment",
      "role": "Required",
      "role_reason": "This condition connects Random-sequence generation, concealment, recruitment order, baseline and assessment with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Random-sequence generation, concealment, recruitment order, baseline and assessment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Allocation generation, concealment, recruitment and baseline-balance procedures are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Are participant, instructor and assessor awareness/contact known?",
      "needed": "Attention/time controls, instruction, contact and measurement/analysis blinding",
      "role": "Required",
      "role_reason": "This condition connects Attention/time controls, instruction, contact and measurement/analysis blinding with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Attention/time controls, instruction, contact and measurement/analysis blinding must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Attention/contact controls, instructors and measurement/analysis blinding materials are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Can baseline pressure and arm differences be linked to final values?",
      "needed": "Arm baseline SBP/DBP, medication, risk and baseline handling",
      "role": "Required",
      "role_reason": "This condition connects Arm baseline SBP/DBP, medication, risk and baseline handling with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Arm baseline SBP/DBP, medication, risk and baseline handling must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Baseline SBP/DBP, medication/risk balance and model handling are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "How was 6-week SBP measured?",
      "needed": "Device, posture, rest, repetitions, setting, time and assessors",
      "role": "Required",
      "role_reason": "This condition connects Device, posture, rest, repetitions, setting, time and assessors with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Device, posture, rest, repetitions, setting, time and assessors must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Measurement devices, settings, repetitions, rest, timing and assessors are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "How does continued medication differ from actual prescription changes?",
      "needed": "Arm medication types, doses, changes, adherence, rescue drugs and timing",
      "role": "Required",
      "role_reason": "This condition connects Arm medication types, doses, changes, adherence, rescue drugs and timing with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Arm medication types, doses, changes, adherence, rescue drugs and timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual medication, doses, adherence, changes and model handling are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Are lifestyle care and other breathing/yoga comparisons distinguished?",
      "needed": "Standard lifestyle management, exercise, diet, contact and other-intervention boundaries",
      "role": "Required",
      "role_reason": "This condition connects Standard lifestyle management, exercise, diet, contact and other-intervention boundaries with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Standard lifestyle management, exercise, diet, contact and other-intervention boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Lifestyle content, arm changes and adherence to other interventions are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Are actual breathing exposure and discontinuation linked to analyses?",
      "needed": "Actual delivery, instruction, adherence, discontinuation, exposure/completion denominators and analysis",
      "role": "Required",
      "role_reason": "This condition connects Actual delivery, instruction, adherence, discontinuation, exposure/completion denominators and analysis with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Actual delivery, instruction, adherence, discontinuation, exposure/completion denominators and analysis must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Adherence, actual exposure, discontinuation reasons and attrition relationships are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Is the CTRI identifier separate from a prospective SBP plan?",
      "needed": "CTRI/2023/11/059625, registration, plans, endpoint hierarchy and timing",
      "role": "Required",
      "role_reason": "This condition connects CTRI/2023/11/059625, registration, plans, endpoint hierarchy and timing with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for CTRI/2023/11/059625, registration, plans, endpoint hierarchy and timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Registration contents, prospective endpoints, recruitment/registration dates and plan amendments are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "How is the null DBP wording preserved?",
      "needed": "Between-group DBP P>.05 versus SBP, effects, CIs and denominators",
      "role": "Required",
      "role_reason": "This condition connects Between-group DBP P>.05 versus SBP, effects, CIs and denominators with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Between-group DBP P>.05 versus SBP, effects, CIs and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Exact DBP values, arm denominators, effects, CIs and plans are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "How does 6-week SBP differ from main-trial HRV?",
      "needed": "Mittal HRV measures, units, timing and analyses versus SBP",
      "role": "Required",
      "role_reason": "This condition connects Mittal HRV measures, units, timing and analyses versus SBP with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Mittal HRV measures, units, timing and analyses versus SBP must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: HRV measures, units, effects, CIs, timing and denominators are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Is the 100-participant HRV comparison direct 6-week SBP evidence?",
      "needed": "Ghiya's other-pranayama acute HRV comparison, original null result and identity",
      "role": "Required",
      "role_reason": "This condition connects Ghiya's other-pranayama acute HRV comparison, original null result and identity with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Ghiya's other-pranayama acute HRV comparison, original null result and identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Exact acute HRV measures, effects, CIs, population, denominators and registration are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "How are reports, populations and endpoints kept from double-counting?",
      "needed": "Mittal/Ghiya bibliographies, registration and report/trial/cohort links",
      "role": "Required",
      "role_reason": "This condition connects Mittal/Ghiya bibliographies, registration and report/trial/cohort links with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Mittal/Ghiya bibliographies, registration and report/trial/cohort links must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report/cohort overlap, registration links and unique-participant/trial counts are unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "What is the verification level of public/academic support wording?",
      "needed": "Report-specific support, COI, roles and independence",
      "role": "Required",
      "role_reason": "This condition connects Report-specific support, COI, roles and independence with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Report-specific support, COI, roles and independence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Support/COI details, involvement, researcher roles and independence materials are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "Is independent SBP evidence available for the same population, components and duration?",
      "needed": "Direct follow-up with matching combined adjunct, population, measurements and denominators",
      "role": "Required",
      "role_reason": "This condition connects Direct follow-up with matching combined adjunct, population, measurements and denominators with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Direct follow-up with matching combined adjunct, population, measurements and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Independent direct evidence for the same question, condition differences and report-family relationships are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Does the 6-week effect persist after the program ends?",
      "needed": "Post-program follow-up, medication, lifestyle care, continuation/discontinuation and pressure",
      "role": "Required",
      "role_reason": "This condition connects Post-program follow-up, medication, lifestyle care, continuation/discontinuation and pressure with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Post-program follow-up, medication, lifestyle care, continuation/discontinuation and pressure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Post-program follow-up, exposure/treatment changes and sustained SBP materials are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N31",
      "question_type": "Evidence condition",
      "question": "Does a final-SBP signal answer cardiovascular-event or medication-replacement questions?",
      "needed": "Pressure surrogates versus separate clinical-event/medication-change comparisons",
      "role": "Required",
      "role_reason": "This condition connects Pressure surrogates versus separate clinical-event/medication-change comparisons with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Pressure surrogates versus separate clinical-event/medication-change comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct long-term clinical-event, medication-change and replacement materials are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N32",
      "question_type": "Evidence condition",
      "question": "What level of material was actually read?",
      "needed": "Stored summaries/bibliographies versus external abstracts, full texts, registration and plans",
      "role": "Required",
      "role_reason": "This condition connects Stored summaries/bibliographies versus external abstracts, full texts, registration and plans with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Stored summaries/bibliographies versus external abstracts, full texts, registration and plans must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: External materials were unread; inaccessibility or access failure was not verified either. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N33",
      "question_type": "Evidence condition",
      "question": "How are the original date, production and review separated?",
      "needed": "Original evidence date, empty correction/deliberation records and historical grade decisions",
      "role": "Required",
      "role_reason": "This condition connects Original evidence date, empty correction/deliberation records and historical grade decisions with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Original evidence date, empty correction/deliberation records and historical grade decisions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Current content-review and new clinical-verification dates are undetermined. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N34",
      "question_type": "Evidence condition",
      "question": "Are both original languages' boundaries preserved?",
      "needed": "Selected claims/notes and combined adjunct, final-value, adjustment and attrition boundaries",
      "role": "Required",
      "role_reason": "This condition connects Selected claims/notes and combined adjunct, final-value, adjustment and attrition boundaries with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Selected claims/notes and combined adjunct, final-value, adjustment and attrition boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Detailed comparison of external papers, Korean/English translations and corrections is unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N35",
      "question_type": "Evidence condition",
      "question": "How are parent axes and absent selected-question fields preserved?",
      "needed": "B/S/R1/I2/EX/B2, unrecorded precision, original booleans and empty overrides",
      "role": "Required",
      "role_reason": "This condition connects B/S/R1/I2/EX/B2, unrecorded precision, original booleans and empty overrides with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for B/S/R1/I2/EX/B2, unrecorded precision, original booleans and empty overrides must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Preserve absent selected score/status/axes and unverified precision. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N36",
      "question_type": "Evidence condition",
      "question": "How were harms defined and collected?",
      "needed": "Original hyperventilation, dizziness and distress warnings versus actual events",
      "role": "Supplementary; required for extending safety conclusions",
      "role_reason": "This condition connects Original hyperventilation, dizziness and distress warnings versus actual events with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Original hyperventilation, dizziness and distress warnings versus actual events must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Harm definitions, collection procedures, assessors and actual event tables are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N37",
      "question_type": "Evidence condition",
      "question": "Are exposure, discontinuation, symptoms and follow-up timing known?",
      "needed": "Actual exposure, symptom/discontinuation timing and during/post-study follow-up",
      "role": "Supplementary; required for extending safety conclusions",
      "role_reason": "This condition connects Actual exposure, symptom/discontinuation timing and during/post-study follow-up with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Actual exposure, symptom/discontinuation timing and during/post-study follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Harm timing, recurrence, recovery and later follow-up are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N38",
      "question_type": "Evidence condition",
      "question": "Were harms compared with standard care using the same methods?",
      "needed": "Arm harm collection, observation windows, cointerventions, discontinuation and comparative tables",
      "role": "Supplementary; required for extending safety conclusions",
      "role_reason": "This condition connects Arm harm collection, observation windows, cointerventions, discontinuation and comparative tables with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Arm harm collection, observation windows, cointerventions, discontinuation and comparative tables must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Comparative harms, matching collection/follow-up and original tables are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N39",
      "question_type": "Evidence condition",
      "question": "Are event counts and exposure denominators available for harm frequencies?",
      "needed": "Actual exposure, observation/analysis n, attrition, harm counts and observation windows",
      "role": "Supplementary; required for extending safety conclusions",
      "role_reason": "This condition connects Actual exposure, observation/analysis n, attrition, harm counts and observation windows with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Actual exposure, observation/analysis n, attrition, harm counts and observation windows must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Harm counts, exposure/observation denominators and discontinuation reasons are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N40",
      "question_type": "Evidence condition",
      "question": "Are medication, lifestyle care and other exposures separated from harm causes?",
      "needed": "Concurrent medication/lifestyle care, baseline disease, attrition and event sequence",
      "role": "Supplementary; required for extending safety conclusions",
      "role_reason": "This condition connects Concurrent medication/lifestyle care, baseline disease, attrition and event sequence with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Concurrent medication/lifestyle care, baseline disease, attrition and event sequence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Concurrent factors, actual events, causality judgments and timing are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N41",
      "question_type": "Evidence condition",
      "question": "How do completion/attrition differ from missing harm reports?",
      "needed": "Attrition/discontinuation reasons, missing symptoms, selective reporting and follow-up",
      "role": "Supplementary; required for extending safety conclusions",
      "role_reason": "This condition connects Attrition/discontinuation reasons, missing symptoms, selective reporting and follow-up with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Attrition/discontinuation reasons, missing symptoms, selective reporting and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Harm-related discontinuation, missing data, selective reporting and later follow-up are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N42",
      "question_type": "Evidence condition",
      "question": "What is known about independent, vulnerable-population and later harms?",
      "needed": "Matching combined exposure, independent reports, vulnerable groups and later harms",
      "role": "Supplementary; required for extending safety conclusions",
      "role_reason": "This condition connects Matching combined exposure, independent reports, vulnerable groups and later harms with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Matching combined exposure, independent reports, vulnerable groups and later harms must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Independent harm, vulnerable-population and later follow-up materials are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N43",
      "question_type": "Evidence condition",
      "question": "How do method copies, frozen conditions, application and content review differ?",
      "needed": "Method copies, applied conditions, originals, versions and creation/application history",
      "role": "Required",
      "role_reason": "This condition connects Method copies, applied conditions, originals, versions and creation/application history with selected 6-week SBP, the combined adjunct, final values, adjusted effects, denominators, attrition, directness and harm boundaries.",
      "application_exception": "Preserve selected C and the note distinguishing final-value differences from unverified adjusted effects/CIs. Distinguish absent subclaim score/status/axes from parent C with 50 points. Existing differences/attrition values do not become new calculations, ITT, personal effects or independent replication. Create no new grades, safety certification or breathing, medication or treatment instructions.",
      "criterion": "Material for Method copies, applied conditions, originals, versions and creation/application history must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: This does not indicate completed content review or new official-method/clinical certification. This records needed materials; no new research was executed."
    }
  ]
}