Wall-sit training × medication replacement and cardiovascular events: directly untested

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionWhich treatment-replacement and event-prevention claims are selected?Required	The selected claims are medication replacement and cardiovascular-event prevention, with original grade ?. Preserve the original note that clinical events and treatment replacement were not tested. Score/status for this question are unrecorded and separate from parent blood-pressure grade C with 54 points. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Exact medication-replacement and cardiovascular-event claims and original grade	Material needed: Direct materials identifying each treatment-replacement and clinical-event question. Do not turn ? into no effect, 0 points or no studies at all. This records needed materials; no new research was executed.
2	Unverified	Full text not readStored summary read	N02 · Evidence conditionWas medication replacement tested directly?Required	Original stored records say medication/treatment replacement was not tested. Pressure results for wall sit versus no exercise are not transferred into medication-replacement effects. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Direct comparative medication-replacement results	Material needed: Clear medication comparison, treatment-replacement endpoints, stability, rescue treatment and long-term follow-up. No medication-change instructions are written. This records needed materials; no new research was executed.
3	Unverified	Full text not readStored summary read	N03 · Evidence conditionIs there comparative evidence of equivalence to medication?Required	The key trial assigned handgrip, wall sit and no exercise; the small trial used wall sit, low-intensity sham and no exercise. Preserve the original record that equivalence to blood-pressure medication was not directly compared. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Direct active-medication comparison and equivalence/noninferiority design	Material needed: Direct medication control, prospective equivalence/noninferiority margins, analysis populations, CIs and actual treatment conditions. Null P values or SBP reductions do not establish medication equivalence. This records needed materials; no new research was executed.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionWas the key trial about reducing existing medication?Required	Key participants were untreated adults aged 35–65 with hypertension. These are not presented as reduction, discontinuation or replacement results in people taking blood-pressure medication. Detailed medication conditions in Decaux are unverified. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Distinguishing untreated participants from people changing existing treatment	Material needed: Baseline/follow-up medication status, eligibility and cointerventions. Preserve population context without writing reduction/discontinuation instructions. This records needed materials; no new research was executed.
5	Unverified	Full text not readStored summary read	N05 · Evidence conditionWere cardiovascular clinical events measured directly?Required	Original records say cardiovascular/clinical events were not tested. Event counts, risks, between-group event effects and CIs are not established by the stored materials. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Event-specific cardiovascular-prevention results	Material needed: Event types, definitions, adjudication, arm events, time at risk, follow-up and competing events. Untested does not mean 0 events or a prevention effect of 0. This records needed materials; no new research was executed.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionIs reduced SBP a direct event-prevention result?Required	Key SBP 141.2→128.3 versus 138.9→138.5 mmHg is a resting-pressure result. The original verdict describes pressure as a surrogate. This is not converted into heart-attack/cardiovascular-event prevention effects. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Distinguishing resting-SBP surrogates from clinical events	Material needed: Direct event comparisons and surrogate-to-event links for the relevant population/duration. No new risk-reduction calculations or hypothetical numerical examples. This records needed materials; no new research was executed.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionHow does the null DBP result differ from the clinical questions?Required	The key between-group DBP difference is stored as null. This is not turned into a direct test showing medication-replacement/event-prevention effects of 0. SBP support is not bundled with DBP/event support. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Separating DBP results from treatment-replacement/event-prevention questions	Material needed: Separate direct treatment-replacement/event materials and DBP analysis tables. Preserve endpoint-specific questions and unverified scope. This records needed materials; no new research was executed.
8	Partly verified	Full text not readStored summary read	N08 · Evidence conditionWhat does the small 4-week sham trial support?Required	Decaux has 30 participants over 4 weeks: SBP -15.2±9.2 and DBP -4.6±5.0 mmHg, with P<.05 versus controls. These stored results contain no direct estimate of medication replacement or event prevention. R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Directness boundaries of Decaux pressure results	Material needed: Actual endpoint hierarchy, medication/event materials and separate direct-question evidence. Short-term pressure support is not counted as independent event-prevention replication. This records needed materials; no new research was executed.
9	Partly verified	Full text not readStored summary read	N09 · Evidence conditionDo initial and maintenance phases establish long-term event prevention?Required	Original records distinguish 3 sessions weekly for the first 12 weeks from later 1-session-weekly maintenance. A bibliographic title about maintained SBP is not a long-term cardiovascular-event result or evidence that 1 session weekly suffices from the start. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Duration boundaries of initial training and later pressure maintenance	Material needed: Phase-specific populations, denominators, actual event follow-up, losses and treatment replacement. Pressure maintenance is not extended into long-term clinical efficacy. This records needed materials; no new research was executed.
10	Unverified	Full text not readStored summary read	N10 · Evidence conditionAre analysis denominators available for events and treatment replacement?Required	The key trial has 77 participants all completed, and the small trial has 30. These are report-specific pressure-study sizes, not established allocation, analysis or time-at-risk denominators for each event/medication-replacement endpoint. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Distinguishing pressure samples from event/medication endpoint denominators	Material needed: Arm analysis denominators, time at risk, missingness, withdrawals and original event tables for direct endpoints. Do not add the reports' n values. This records needed materials; no new research was executed.
11	Unverified	Full text not readStored summary read	N11 · Evidence conditionAre cointerventions and rescue treatments verified?Required	Key stored participants were untreated and the actual control was no exercise. Detailed originals on follow-up cointerventions, rescue treatment and medication changes are unverified. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Medication, other exercise, lifestyle changes and actual controls	Material needed: Cointerventions, rescue treatment, adherence, intervention departures and treatment-change records. Leave these as material needs without medication-change instructions. This records needed materials; no new research was executed.
12	Unverified	Full text not readStored summary read	N12 · Evidence conditionWere event prevention and medication replacement prospective endpoints?Required	Original records say these outcomes were not tested, and the parent verdict's prospective endpoint hierarchy is unverified. NCT05025202 in the citation does not verify prospective registration of these claims. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Prospective status and analysis plans for direct clinical endpoints	Material needed: Original timing, amendment history, prospective clinical endpoints and analysis plans in registration, protocols and SAPs. External registration/plans were not read this time. This records needed materials; no new research was executed.
13	Partly verified	Full text not readStored summary read	N13 · Evidence conditionDo 0 reported adverse events establish cardiovascular protection?Required	Original text says the key 77-participant trial reported 0 adverse events. A separate acute study records pressure responses during holds. These safety contexts are not direct event-prevention results. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Separating harm collection from cardiovascular-event prevention	Material needed: Harm definitions, collection, arm exposure, denominators, actual event adjudication and long-term follow-up. 0 reports do not establish no harm or cardiovascular protection. This records needed materials; no new research was executed.
14	Unverified	Full text not readStored summary read	N14 · Evidence conditionWhat materials would answer the direct clinical questions?Required	Current stored materials concern small supervised resting-pressure studies; direct medication-replacement/cardiovascular-event evidence is unverified. Keep material needs separate for the clinical questions. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Separate direct evidence for medication replacement and event prevention	Material needed: Actual direct medication comparisons, endpoints, CIs and adequate clinical-event follow-up, denominators and definitions. Record needed materials without new research, independence certification or treatment instructions. This records needed materials; no new research was executed.
15	Partly verified	Full text not readStored summary read	N15 · Evidence conditionAre shared reports being counted as new trials?Required	Parent verdict 3000 and its subclaim questions share the Cohen/Decaux reports. Report/sheet counts and 77/30 participants are not made into new independent-trial/participant totals. Unique-trial counts and unique-participant totals are unverified. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Links among reports, trials and selected questions	Material needed: Report, cohort and analysis-population identifiers and shared relationships. No new unique-trial/participant totals or independent-replication certification. This records needed materials; no new research was executed.
16	Partly verified	Full text not readStored summary read	N16 · Evidence conditionWhich materials were actually read?Required	The complete stored parent-verdict summary was read and a copy preserved. PubMed URLs, PMCID, DOI and NCT values come from original bibliographies. External abstracts, full texts, registration, protocols and SAPs were unread this time. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Distinguishing stored summaries from external originals	Material needed: Actually acquired originals, supplements and access records. A URL or historical verification statement does not become current full-text reading or a met condition. This records needed materials; no new research was executed.
17	Partly verified	Full text not readStored summary read	N17 · Evidence conditionWhere are bibliographies and registration identifiers recorded?Required	Cohen has PMID 36965163, PMCID PMC10085809 and DOI 10.1111/jch.14621. Decaux has PMID 35083878, PMCID PMC8792514, DOI 10.14814/phy2.15112 and NCT05025202. NCT appears in the Decaux citation; evidence summaries have no separate registration field. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Report-specific bibliographic/registration locations	Material needed: Paper/registration identities, dates and material links. Do not infer new URLs from identifiers or claim registration contents were verified. This records needed materials; no new research was executed.
18	Partly verified	Full text not readStored summary read	N18 · Evidence conditionHow are original languages and historical verification statements preserved?Required	Preserve original Korean/English wording, selected claims/notes and historical key/sham RCT, funding and acute-safety verification statements from the parent verdict. This production is not a new content review or external-original cross-check. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original Korean/English wording, selected-claim notes and historical scope	Material needed: Review of originals, translations and corrections. Historical verification wording is not relabeled as passing current review. This records needed materials; no new research was executed.
19	Partly verified	Full text not readStored summary read	N19 · Evidence conditionAre selected-question grades/axes separate from the parent verdict?Required	Preserve selected original grade ? and its note; score/status are unrecorded. Parent C 54, caution and B/S/R1/I2/E+/B1/CX axes are pressure-verdict context. They are not transferred into treatment-replacement/cardiovascular-event scores or independence certification. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Selected original grade, absent score and parent context	Material needed: Review of selected-question boundaries/content. No new scoring, axis changes or copying of parent scores. This records needed materials; no new research was executed.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionWhat are the evidence date and correction records?Required	The original evidence date is 2026-09-07; corrections are an empty array and deliberation an empty string. These are not production/review dates or certification that no external corrections exist. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Distinguishing the original date and empty records from production	Material needed: Latest corrections, follow-up materials and original histories. No arbitrary new evidence date, correction or verdict value. This records needed materials; no new research was executed.
21	Partly verified	Full text not readStored summary read	N21 · Evidence conditionAre funding, product support, employee authors and analysis involvement distinguished?Required	Cohen is stored as Colombian Ministry of Science/Colciencias with no COI declared; Decaux has funding information not provided. Public funding/COI declarations differ from detailed verification of product support, company employee authors and company analysis/reporting involvement. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Report-specific funding and company-related items	Material needed: Report-specific funding, support, affiliations and analysis/publication-role originals. Unprovided funding does not mean no company; parent I2 is not newly certified. This records needed materials; no new research was executed.
22	Unverified	Full text not readStored summary read	N22 · Evidence conditionAre allocation, blinding and pressure-measurement bias materials available?Required	Designs are preserved as Cohen's multicenter 3-arm randomized trial and Decaux's randomized sham trial. Allocation concealment, assessor blinding, devices, repeated measurements and selective-reporting details are unverified. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Allocation, measurement and selective reporting	Material needed: Methods, protocols, SAPs, original measurements and amendment histories. A design label does not establish formal RoB/GRADE or passed review. This records needed materials; no new research was executed.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionAre study conditions separate from actual delivery and cointerventions?Required	Original study descriptions contain training, rest, frequency and phase information. Preserve these as study identifiers. Actual arm adherence, cumulative exposure, concurrent exercise and medication changes are unverified; exposure totals are not calculated. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Intervention identification versus actual exposure	Material needed: Actual arm exposure, departures, cointerventions and analysis effects. No execution procedures, intensity-setting methods or medication reduction/replacement instructions. This records needed materials; no new research was executed.
24	Partly verified	Full text not readStored summary read	N24 · Evidence conditionAre acute in-exercise pressure and resting results distinguished?Supplementary	Original safety text records mean 196/112 mmHg during a 90° hold in a separate acute study. This differs from long-term resting results; its bibliography, population and denominators are not separately identified in the current 2 citations.	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Separate acute timing and report identity	Material needed: Acute-study originals, populations, denominators, timing, exposure and links to resting results. Acute values do not create long-term harm rates, event-prevention effects or exercise instructions. This records needed materials; no new research was executed.
25	Partly verified	Full text not readStored summary read	N25 · Evidence conditionWhat is the scope of 0 reported adverse events?Supplementary	Original records say all 77 key-trial participants completed and 0 adverse events were reported. Preserve the limited supervised-sample boundary. Definitions, active collection, arm exposure and specific harm-analysis denominators are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Harm collection, exposure and arm denominators	Material needed: Harm definitions, collection, arm exposure/denominators, withdrawals and original severity tables. 0 reports do not establish complete safety or no harm. This records needed materials; no new research was executed.
26	Unverified	Full text not readStored summary read	N26 · Evidence conditionAre long-term/rare harms and post-training effects known?Supplementary	The key trial concerns initial 12-week training and maintenance; the small trial spans 4 weeks. This summary does not establish post-training treatment replacement, cardiovascular events, rare harms, actual long-term events or unsupervised-population details. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Short-term/maintenance versus long-term clinical/harm boundaries	Material needed: Actual long-term follow-up, harm surveillance, endpoint denominators and matching interventions/populations. Short reports or parent caution do not create new long-term safety/efficacy certification. This records needed materials; no new research was executed.
27	Partly verified	Full text not readStored summary read	N27 · Evidence conditionWhat would trigger an update?Required	This is a treatment-replacement/cardiovascular-event sheet based on stored materials. Relevant observations can be updated after reviewing external materials, condition details, denominators, endpoints, timing and shared-report links. Independence/grades are not newly established. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original material, conditions, observations and verdict changes	Material needed: New originals, complete pre-change copies, condition versions, application events and review records. Distinguish material registration from content/verdict changes. This records needed materials; no new research was executed.

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27 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-09-07
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: Cohen has 77 untreated adults aged 35–65 with hypertension, all completed. Decaux has a separate 30 participants; detailed eligibility, blood-pressure medication, comorbidities and age are unverified. These samples do not fill arm denominators for reducing, stopping or replacing existing medication or for event endpoints.
Ingredient, formulation and route: Knee angle, intensity calibration and supervision belong to original supervised isometric wall-squat/wall-sit conditions. Report-specific actual delivery, adherence and cointerventions are unverified. Research identification context is not turned into personal exercise, breathing, medication-change or treatment instructions.
Dose: Distinguish original initial training 3 times weekly for 12 weeks, 4 holds of 2 minutes with 2-minute seated rests, and later maintenance 1 time weekly. Maintenance allocation, denominators and exact results are unverified. 1 time weekly is not treated as an adequate starting dose.
Comparator: Cohen has 3 handgrip, wall-sit and no-exercise arms; Decaux has wall sit, low-intensity sham and no exercise. Direct medication comparison, equivalence, noninferiority and treatment replacement were not tested. Pressure changes or null results do not establish medication equivalence.
Measured outcome: The selected questions are medication replacement and cardiovascular-event prevention. Original stored records say these were directly untested. Event counts, risks, between-group effects and CIs are unverified. Resting SBP and DBP are separate pressure outcomes; untested does not mean 0 events or an effect of 0, and pressure signals are not converted into clinical-event effects.
Duration: Distinguish key initial 12-week training and later maintenance, Decaux 4 weeks, and mean 196/112 mmHg during a separate acute 90° hold. These time points do not become long-term event-prevention or treatment-replacement follow-up. Post-training clinical outcomes and the acute study bibliography, population and denominators are unverified.
Questions outside this scope: Converting directly untested into 0 events, an effect of 0, equivalence or no studies at all; Transferring later once-weekly maintenance into a minimum starting dose; Combining resting SBP, DBP and acute in-exercise pressure as one result; Extending a blood-pressure surrogate to medication equivalence, dose reduction/replacement or cardiovascular-event prevention; Adding arms, outcomes, maintenance phases, related reports or sheets into new unique-trial/participant or independent-replication totals; Using original grades, public funding, COI declarations or 0 reported adverse events as new verdicts or independence/safety certification; Creating new numbers, effects, CIs, grades or exercise, breathing, medication reduction/replacement or treatment instructions

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

R01 · Cohen DD, Aroca-Martinez G, Carreño-Robayo J, et al. Reductions in systolic blood pressure achieved by hypertensives with three isometric training sessions per week are maintained with a single session per week. J Clin Hypertens. 2023;25(4):380-387. PMID: 36965163. PMCID: PMC10085809. DOI: 10.1111/jch.14621.

PubMed

Material type: Multicenter three-arm randomized trial
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary: SBP 141.2 to 128.3 vs 138.9 to 138.5 mmHg; DBP between-group null
Record level: Stored summary of a resting-pressure study. This is not a direct comparison of medication replacement, medication equivalence or cardiovascular-event prevention. Endpoint-specific event counts, time at risk, arm analysis denominators, effects and CIs are unverified. No new clinical effect is calculated from pressure reductions or 0 reported adverse events.
Study overlap and independent replication: Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.

R02 · Decaux A et al. Blood pressure and cardiac autonomic adaptations to isometric exercise training: A randomized sham-controlled study. Physiol Rep. 2022;10(2):e15112. PMID: 35083878. PMCID: PMC8792514. DOI: 10.14814/phy2.15112. NCT05025202.

PubMed

Material type: Randomized wall-sit, low-intensity sham, and no-exercise trial
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary: SBP -15.2±9.2 and DBP -4.6±5.0 mmHg; P<.05 vs controls
Record level: Stored summary of a resting-pressure study. This is not a direct comparison of medication replacement, medication equivalence or cardiovascular-event prevention. Endpoint-specific event counts, time at risk, arm analysis denominators, effects and CIs are unverified. No new clinical effect is calculated from pressure reductions or 0 reported adverse events.
Study overlap and independent replication: Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.

Report counts versus independent study counts

Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which treatment-replacement and event-prevention claims are selected?

Required materials and conditions: Exact medication-replacement and cardiovascular-event claims and original grade
Conditions for verification: Material for Exact medication-replacement and cardiovascular-event claims and original grade must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Exact medication-replacement and cardiovascular-event claims and original grade with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N02 · Was medication replacement tested directly?

Required materials and conditions: Direct comparative medication-replacement results
Conditions for verification: Material for Direct comparative medication-replacement results must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Direct comparative medication-replacement results with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N03 · Is there comparative evidence of equivalence to medication?

Required materials and conditions: Direct active-medication comparison and equivalence/noninferiority design
Conditions for verification: Material for Direct active-medication comparison and equivalence/noninferiority design must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Direct active-medication comparison and equivalence/noninferiority design with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N04 · Was the key trial about reducing existing medication?

Required materials and conditions: Distinguishing untreated participants from people changing existing treatment
Conditions for verification: Material for Distinguishing untreated participants from people changing existing treatment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Distinguishing untreated participants from people changing existing treatment with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N05 · Were cardiovascular clinical events measured directly?

Required materials and conditions: Event-specific cardiovascular-prevention results
Conditions for verification: Material for Event-specific cardiovascular-prevention results must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Event-specific cardiovascular-prevention results with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N06 · Is reduced SBP a direct event-prevention result?

Required materials and conditions: Distinguishing resting-SBP surrogates from clinical events
Conditions for verification: Material for Distinguishing resting-SBP surrogates from clinical events must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Distinguishing resting-SBP surrogates from clinical events with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N07 · How does the null DBP result differ from the clinical questions?

Required materials and conditions: Separating DBP results from treatment-replacement/event-prevention questions
Conditions for verification: Material for Separating DBP results from treatment-replacement/event-prevention questions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Separating DBP results from treatment-replacement/event-prevention questions with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N08 · What does the small 4-week sham trial support?

Required materials and conditions: Directness boundaries of Decaux pressure results
Conditions for verification: Material for Directness boundaries of Decaux pressure results must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Directness boundaries of Decaux pressure results with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N09 · Do initial and maintenance phases establish long-term event prevention?

Required materials and conditions: Duration boundaries of initial training and later pressure maintenance
Conditions for verification: Material for Duration boundaries of initial training and later pressure maintenance must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Duration boundaries of initial training and later pressure maintenance with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N10 · Are analysis denominators available for events and treatment replacement?

Required materials and conditions: Distinguishing pressure samples from event/medication endpoint denominators
Conditions for verification: Material for Distinguishing pressure samples from event/medication endpoint denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Distinguishing pressure samples from event/medication endpoint denominators with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N11 · Are cointerventions and rescue treatments verified?

Required materials and conditions: Medication, other exercise, lifestyle changes and actual controls
Conditions for verification: Material for Medication, other exercise, lifestyle changes and actual controls must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Medication, other exercise, lifestyle changes and actual controls with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N12 · Were event prevention and medication replacement prospective endpoints?

Required materials and conditions: Prospective status and analysis plans for direct clinical endpoints
Conditions for verification: Material for Prospective status and analysis plans for direct clinical endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Prospective status and analysis plans for direct clinical endpoints with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N13 · Do 0 reported adverse events establish cardiovascular protection?

Required materials and conditions: Separating harm collection from cardiovascular-event prevention
Conditions for verification: Material for Separating harm collection from cardiovascular-event prevention must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Separating harm collection from cardiovascular-event prevention with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N14 · What materials would answer the direct clinical questions?

Required materials and conditions: Separate direct evidence for medication replacement and event prevention
Conditions for verification: Material for Separate direct evidence for medication replacement and event prevention must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Separate direct evidence for medication replacement and event prevention with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N15 · Are shared reports being counted as new trials?

Required materials and conditions: Links among reports, trials and selected questions
Conditions for verification: Material for Links among reports, trials and selected questions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Links among reports, trials and selected questions with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N16 · Which materials were actually read?

Required materials and conditions: Distinguishing stored summaries from external originals
Conditions for verification: Material for Distinguishing stored summaries from external originals must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Distinguishing stored summaries from external originals with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N17 · Where are bibliographies and registration identifiers recorded?

Required materials and conditions: Report-specific bibliographic/registration locations
Conditions for verification: Material for Report-specific bibliographic/registration locations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Report-specific bibliographic/registration locations with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N18 · How are original languages and historical verification statements preserved?

Required materials and conditions: Original Korean/English wording, selected-claim notes and historical scope
Conditions for verification: Material for Original Korean/English wording, selected-claim notes and historical scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Original Korean/English wording, selected-claim notes and historical scope with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N19 · Are selected-question grades/axes separate from the parent verdict?

Required materials and conditions: Selected original grade, absent score and parent context
Conditions for verification: Material for Selected original grade, absent score and parent context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Selected original grade, absent score and parent context with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N20 · What are the evidence date and correction records?

Required materials and conditions: Distinguishing the original date and empty records from production
Conditions for verification: Material for Distinguishing the original date and empty records from production must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Distinguishing the original date and empty records from production with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N21 · Are funding, product support, employee authors and analysis involvement distinguished?

Required materials and conditions: Report-specific funding and company-related items
Conditions for verification: Material for Report-specific funding and company-related items must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Report-specific funding and company-related items with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N22 · Are allocation, blinding and pressure-measurement bias materials available?

Required materials and conditions: Allocation, measurement and selective reporting
Conditions for verification: Material for Allocation, measurement and selective reporting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Allocation, measurement and selective-reporting conditions with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N23 · Are study conditions separate from actual delivery and cointerventions?

Required materials and conditions: Intervention identification versus actual exposure
Conditions for verification: Material for Intervention identification versus actual exposure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Intervention identification versus actual exposure with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N24 · Are acute in-exercise pressure and resting results distinguished?

Required materials and conditions: Separate acute timing and report identity
Conditions for verification: Material for Separate acute timing and report identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Separate acute timing and report identity with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N25 · What is the scope of 0 reported adverse events?

Required materials and conditions: Harm collection, exposure and arm denominators
Conditions for verification: Material for Harm collection, exposure and arm denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Harm collection, exposure and arm denominators with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N26 · Are long-term/rare harms and post-training effects known?

Required materials and conditions: Short-term/maintenance versus long-term clinical/harm boundaries
Conditions for verification: Material for Short-term/maintenance versus long-term clinical/harm boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Short-term/maintenance versus long-term clinical/harm boundaries with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N27 · What would trigger an update?

Required materials and conditions: Original material, conditions, observations and verdict changes
Conditions for verification: Material for Original material, conditions, observations and verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Distinguishing source, condition, observation and verdict changes with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

What the statuses mean

Partly verified: Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified
Unverified: Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety
Review incomplete: Awaiting user review
Met: Use only within the relevant condition's scope after user review; no automatic display in this preparation
Not reported: Distinguish only within materials actually read; do not turn unread external materials into unreported findings
Inaccessible: Not applied during this preparation because actual access was not tested
Not applicable: Use with a reason for non-applicability based on an explicit question boundary
Conflicting data: Judge after actual material comparison; review was not performed during this preparation
Insufficient evidence for the conditions: Do not use as a clinical grade encompassing currently unread materials

Change history

2026-10-18 · Public page/material version 1.0

Public pages and materials were prepared from the existing 27 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-09-07) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which treatment-replacement and event-prevention claims are selected?

Current findings: The selected claims are medication replacement and cardiovascular-event prevention, with original grade ?. Preserve the original note that clinical events and treatment replacement were not tested. Score/status for this question are unrecorded and separate from parent blood-pressure grade C with 54 points.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Direct materials identifying each treatment-replacement and clinical-event question. Do not turn ? into no effect, 0 points or no studies at all.
Required materials and conditions: Exact medication-replacement and cardiovascular-event claims and original grade
Materials to obtain first: Direct materials identifying each treatment-replacement and clinical-event question. Do not turn ? into no effect, 0 points or no studies at all.
Further research: Material needed: Direct materials identifying each treatment-replacement and clinical-event question. Do not turn ? into no effect, 0 points or no studies at all. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Exact medication-replacement and cardiovascular-event claims and original grade must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Exact medication-replacement and cardiovascular-event claims and original grade with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N02 · Was medication replacement tested directly?

Current findings: Original stored records say medication/treatment replacement was not tested. Pressure results for wall sit versus no exercise are not transferred into medication-replacement effects.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Clear medication comparison, treatment-replacement endpoints, stability, rescue treatment and long-term follow-up. No medication-change instructions are written.
Required materials and conditions: Direct comparative medication-replacement results
Materials to obtain first: Clear medication comparison, treatment-replacement endpoints, stability, rescue treatment and long-term follow-up. No medication-change instructions are written.
Further research: Material needed: Clear medication comparison, treatment-replacement endpoints, stability, rescue treatment and long-term follow-up. No medication-change instructions are written. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Direct comparative medication-replacement results must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Direct comparative medication-replacement results with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N03 · Is there comparative evidence of equivalence to medication?

Current findings: The key trial assigned handgrip, wall sit and no exercise; the small trial used wall sit, low-intensity sham and no exercise. Preserve the original record that equivalence to blood-pressure medication was not directly compared.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Direct medication control, prospective equivalence/noninferiority margins, analysis populations, CIs and actual treatment conditions. Null P values or SBP reductions do not establish medication equivalence.
Required materials and conditions: Direct active-medication comparison and equivalence/noninferiority design
Materials to obtain first: Direct medication control, prospective equivalence/noninferiority margins, analysis populations, CIs and actual treatment conditions. Null P values or SBP reductions do not establish medication equivalence.
Further research: Material needed: Direct medication control, prospective equivalence/noninferiority margins, analysis populations, CIs and actual treatment conditions. Null P values or SBP reductions do not establish medication equivalence. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Direct active-medication comparison and equivalence/noninferiority design must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Direct active-medication comparison and equivalence/noninferiority design with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N04 · Was the key trial about reducing existing medication?

Current findings: Key participants were untreated adults aged 35–65 with hypertension. These are not presented as reduction, discontinuation or replacement results in people taking blood-pressure medication. Detailed medication conditions in Decaux are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Baseline/follow-up medication status, eligibility and cointerventions. Preserve population context without writing reduction/discontinuation instructions.
Required materials and conditions: Distinguishing untreated participants from people changing existing treatment
Materials to obtain first: Baseline/follow-up medication status, eligibility and cointerventions. Preserve population context without writing reduction/discontinuation instructions.
Further research: Material needed: Baseline/follow-up medication status, eligibility and cointerventions. Preserve population context without writing reduction/discontinuation instructions. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Distinguishing untreated participants from people changing existing treatment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Distinguishing untreated participants from people changing existing treatment with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N05 · Were cardiovascular clinical events measured directly?

Current findings: Original records say cardiovascular/clinical events were not tested. Event counts, risks, between-group event effects and CIs are not established by the stored materials.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Event types, definitions, adjudication, arm events, time at risk, follow-up and competing events. Untested does not mean 0 events or a prevention effect of 0.
Required materials and conditions: Event-specific cardiovascular-prevention results
Materials to obtain first: Event types, definitions, adjudication, arm events, time at risk, follow-up and competing events. Untested does not mean 0 events or a prevention effect of 0.
Further research: Material needed: Event types, definitions, adjudication, arm events, time at risk, follow-up and competing events. Untested does not mean 0 events or a prevention effect of 0. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Event-specific cardiovascular-prevention results must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Event-specific cardiovascular-prevention results with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N06 · Is reduced SBP a direct event-prevention result?

Current findings: Key SBP 141.2→128.3 versus 138.9→138.5 mmHg is a resting-pressure result. The original verdict describes pressure as a surrogate. This is not converted into heart-attack/cardiovascular-event prevention effects.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Direct event comparisons and surrogate-to-event links for the relevant population/duration. No new risk-reduction calculations or hypothetical numerical examples.
Required materials and conditions: Distinguishing resting-SBP surrogates from clinical events
Materials to obtain first: Direct event comparisons and surrogate-to-event links for the relevant population/duration. No new risk-reduction calculations or hypothetical numerical examples.
Further research: Material needed: Direct event comparisons and surrogate-to-event links for the relevant population/duration. No new risk-reduction calculations or hypothetical numerical examples. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Distinguishing resting-SBP surrogates from clinical events must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Distinguishing resting-SBP surrogates from clinical events with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N07 · How does the null DBP result differ from the clinical questions?

Current findings: The key between-group DBP difference is stored as null. This is not turned into a direct test showing medication-replacement/event-prevention effects of 0. SBP support is not bundled with DBP/event support.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Separate direct treatment-replacement/event materials and DBP analysis tables. Preserve endpoint-specific questions and unverified scope.
Required materials and conditions: Separating DBP results from treatment-replacement/event-prevention questions
Materials to obtain first: Separate direct treatment-replacement/event materials and DBP analysis tables. Preserve endpoint-specific questions and unverified scope.
Further research: Material needed: Separate direct treatment-replacement/event materials and DBP analysis tables. Preserve endpoint-specific questions and unverified scope. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Separating DBP results from treatment-replacement/event-prevention questions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Separating DBP results from treatment-replacement/event-prevention questions with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N08 · What does the small 4-week sham trial support?

Current findings: Decaux has 30 participants over 4 weeks: SBP -15.2±9.2 and DBP -4.6±5.0 mmHg, with P<.05 versus controls. These stored results contain no direct estimate of medication replacement or event prevention.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Actual endpoint hierarchy, medication/event materials and separate direct-question evidence. Short-term pressure support is not counted as independent event-prevention replication.
Required materials and conditions: Directness boundaries of Decaux pressure results
Materials to obtain first: Actual endpoint hierarchy, medication/event materials and separate direct-question evidence. Short-term pressure support is not counted as independent event-prevention replication.
Further research: Material needed: Actual endpoint hierarchy, medication/event materials and separate direct-question evidence. Short-term pressure support is not counted as independent event-prevention replication. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Directness boundaries of Decaux pressure results must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Directness boundaries of Decaux pressure results with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02

N09 · Do initial and maintenance phases establish long-term event prevention?

Current findings: Original records distinguish 3 sessions weekly for the first 12 weeks from later 1-session-weekly maintenance. A bibliographic title about maintained SBP is not a long-term cardiovascular-event result or evidence that 1 session weekly suffices from the start.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Phase-specific populations, denominators, actual event follow-up, losses and treatment replacement. Pressure maintenance is not extended into long-term clinical efficacy.
Required materials and conditions: Duration boundaries of initial training and later pressure maintenance
Materials to obtain first: Phase-specific populations, denominators, actual event follow-up, losses and treatment replacement. Pressure maintenance is not extended into long-term clinical efficacy.
Further research: Material needed: Phase-specific populations, denominators, actual event follow-up, losses and treatment replacement. Pressure maintenance is not extended into long-term clinical efficacy. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Duration boundaries of initial training and later pressure maintenance must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Duration boundaries of initial training and later pressure maintenance with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N10 · Are analysis denominators available for events and treatment replacement?

Current findings: The key trial has 77 participants all completed, and the small trial has 30. These are report-specific pressure-study sizes, not established allocation, analysis or time-at-risk denominators for each event/medication-replacement endpoint.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm analysis denominators, time at risk, missingness, withdrawals and original event tables for direct endpoints. Do not add the reports' n values.
Required materials and conditions: Distinguishing pressure samples from event/medication endpoint denominators
Materials to obtain first: Arm analysis denominators, time at risk, missingness, withdrawals and original event tables for direct endpoints. Do not add the reports' n values.
Further research: Material needed: Arm analysis denominators, time at risk, missingness, withdrawals and original event tables for direct endpoints. Do not add the reports' n values. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Distinguishing pressure samples from event/medication endpoint denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Distinguishing pressure samples from event/medication endpoint denominators with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N11 · Are cointerventions and rescue treatments verified?

Current findings: Key stored participants were untreated and the actual control was no exercise. Detailed originals on follow-up cointerventions, rescue treatment and medication changes are unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Cointerventions, rescue treatment, adherence, intervention departures and treatment-change records. Leave these as material needs without medication-change instructions.
Required materials and conditions: Medication, other exercise, lifestyle changes and actual controls
Materials to obtain first: Cointerventions, rescue treatment, adherence, intervention departures and treatment-change records. Leave these as material needs without medication-change instructions.
Further research: Material needed: Cointerventions, rescue treatment, adherence, intervention departures and treatment-change records. Leave these as material needs without medication-change instructions. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Medication, other exercise, lifestyle changes and actual controls must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Medication, other exercise, lifestyle changes and actual controls with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N12 · Were event prevention and medication replacement prospective endpoints?

Current findings: Original records say these outcomes were not tested, and the parent verdict's prospective endpoint hierarchy is unverified. NCT05025202 in the citation does not verify prospective registration of these claims.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original timing, amendment history, prospective clinical endpoints and analysis plans in registration, protocols and SAPs. External registration/plans were not read this time.
Required materials and conditions: Prospective status and analysis plans for direct clinical endpoints
Materials to obtain first: Original timing, amendment history, prospective clinical endpoints and analysis plans in registration, protocols and SAPs. External registration/plans were not read this time.
Further research: Material needed: Original timing, amendment history, prospective clinical endpoints and analysis plans in registration, protocols and SAPs. External registration/plans were not read this time. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Prospective status and analysis plans for direct clinical endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Prospective status and analysis plans for direct clinical endpoints with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N13 · Do 0 reported adverse events establish cardiovascular protection?

Current findings: Original text says the key 77-participant trial reported 0 adverse events. A separate acute study records pressure responses during holds. These safety contexts are not direct event-prevention results.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Harm definitions, collection, arm exposure, denominators, actual event adjudication and long-term follow-up. 0 reports do not establish no harm or cardiovascular protection.
Required materials and conditions: Separating harm collection from cardiovascular-event prevention
Materials to obtain first: Harm definitions, collection, arm exposure, denominators, actual event adjudication and long-term follow-up. 0 reports do not establish no harm or cardiovascular protection.
Further research: Material needed: Harm definitions, collection, arm exposure, denominators, actual event adjudication and long-term follow-up. 0 reports do not establish no harm or cardiovascular protection. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Separating harm collection from cardiovascular-event prevention must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Separating harm collection from cardiovascular-event prevention with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N14 · What materials would answer the direct clinical questions?

Current findings: Current stored materials concern small supervised resting-pressure studies; direct medication-replacement/cardiovascular-event evidence is unverified. Keep material needs separate for the clinical questions.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Actual direct medication comparisons, endpoints, CIs and adequate clinical-event follow-up, denominators and definitions. Record needed materials without new research, independence certification or treatment instructions.
Required materials and conditions: Separate direct evidence for medication replacement and event prevention
Materials to obtain first: Actual direct medication comparisons, endpoints, CIs and adequate clinical-event follow-up, denominators and definitions. Record needed materials without new research, independence certification or treatment instructions.
Further research: Material needed: Actual direct medication comparisons, endpoints, CIs and adequate clinical-event follow-up, denominators and definitions. Record needed materials without new research, independence certification or treatment instructions. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Separate direct evidence for medication replacement and event prevention must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Separate direct evidence for medication replacement and event prevention with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N15 · Are shared reports being counted as new trials?

Current findings: Parent verdict 3000 and its subclaim questions share the Cohen/Decaux reports. Report/sheet counts and 77/30 participants are not made into new independent-trial/participant totals. Unique-trial counts and unique-participant totals are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Report, cohort and analysis-population identifiers and shared relationships. No new unique-trial/participant totals or independent-replication certification.
Required materials and conditions: Links among reports, trials and selected questions
Materials to obtain first: Report, cohort and analysis-population identifiers and shared relationships. No new unique-trial/participant totals or independent-replication certification.
Further research: Material needed: Report, cohort and analysis-population identifiers and shared relationships. No new unique-trial/participant totals or independent-replication certification. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Links among reports, trials and selected questions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Links among reports, trials and selected questions with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N16 · Which materials were actually read?

Current findings: The complete stored parent-verdict summary was read and a copy preserved. PubMed URLs, PMCID, DOI and NCT values come from original bibliographies. External abstracts, full texts, registration, protocols and SAPs were unread this time.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Actually acquired originals, supplements and access records. A URL or historical verification statement does not become current full-text reading or a met condition.
Required materials and conditions: Distinguishing stored summaries from external originals
Materials to obtain first: Actually acquired originals, supplements and access records. A URL or historical verification statement does not become current full-text reading or a met condition.
Further research: Material needed: Actually acquired originals, supplements and access records. A URL or historical verification statement does not become current full-text reading or a met condition. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Distinguishing stored summaries from external originals must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Distinguishing stored summaries from external originals with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N17 · Where are bibliographies and registration identifiers recorded?

Current findings: Cohen has PMID 36965163, PMCID PMC10085809 and DOI 10.1111/jch.14621. Decaux has PMID 35083878, PMCID PMC8792514, DOI 10.14814/phy2.15112 and NCT05025202. NCT appears in the Decaux citation; evidence summaries have no separate registration field.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Paper/registration identities, dates and material links. Do not infer new URLs from identifiers or claim registration contents were verified.
Required materials and conditions: Report-specific bibliographic/registration locations
Materials to obtain first: Paper/registration identities, dates and material links. Do not infer new URLs from identifiers or claim registration contents were verified.
Further research: Material needed: Paper/registration identities, dates and material links. Do not infer new URLs from identifiers or claim registration contents were verified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Report-specific bibliographic/registration locations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Report-specific bibliographic/registration locations with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N18 · How are original languages and historical verification statements preserved?

Current findings: Preserve original Korean/English wording, selected claims/notes and historical key/sham RCT, funding and acute-safety verification statements from the parent verdict. This production is not a new content review or external-original cross-check.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Review of originals, translations and corrections. Historical verification wording is not relabeled as passing current review.
Required materials and conditions: Original Korean/English wording, selected-claim notes and historical scope
Materials to obtain first: Review of originals, translations and corrections. Historical verification wording is not relabeled as passing current review.
Further research: Material needed: Review of originals, translations and corrections. Historical verification wording is not relabeled as passing current review. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original Korean/English wording, selected-claim notes and historical scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original Korean/English wording, selected-claim notes and historical scope with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N19 · Are selected-question grades/axes separate from the parent verdict?

Current findings: Preserve selected original grade ? and its note; score/status are unrecorded. Parent C 54, caution and B/S/R1/I2/E+/B1/CX axes are pressure-verdict context. They are not transferred into treatment-replacement/cardiovascular-event scores or independence certification.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Review of selected-question boundaries/content. No new scoring, axis changes or copying of parent scores.
Required materials and conditions: Selected original grade, absent score and parent context
Materials to obtain first: Review of selected-question boundaries/content. No new scoring, axis changes or copying of parent scores.
Further research: Material needed: Review of selected-question boundaries/content. No new scoring, axis changes or copying of parent scores. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Selected original grade, absent score and parent context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Selected original grade, absent score and parent context with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N20 · What are the evidence date and correction records?

Current findings: The original evidence date is 2026-09-07; corrections are an empty array and deliberation an empty string. These are not production/review dates or certification that no external corrections exist.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Latest corrections, follow-up materials and original histories. No arbitrary new evidence date, correction or verdict value.
Required materials and conditions: Distinguishing the original date and empty records from production
Materials to obtain first: Latest corrections, follow-up materials and original histories. No arbitrary new evidence date, correction or verdict value.
Further research: Material needed: Latest corrections, follow-up materials and original histories. No arbitrary new evidence date, correction or verdict value. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Distinguishing the original date and empty records from production must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Distinguishing the original date and empty records from production with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N21 · Are funding, product support, employee authors and analysis involvement distinguished?

Current findings: Cohen is stored as Colombian Ministry of Science/Colciencias with no COI declared; Decaux has funding information not provided. Public funding/COI declarations differ from detailed verification of product support, company employee authors and company analysis/reporting involvement.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Report-specific funding, support, affiliations and analysis/publication-role originals. Unprovided funding does not mean no company; parent I2 is not newly certified.
Required materials and conditions: Report-specific funding and company-related items
Materials to obtain first: Report-specific funding, support, affiliations and analysis/publication-role originals. Unprovided funding does not mean no company; parent I2 is not newly certified.
Further research: Material needed: Report-specific funding, support, affiliations and analysis/publication-role originals. Unprovided funding does not mean no company; parent I2 is not newly certified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Report-specific funding and company-related items must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Report-specific funding and company-related items with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N22 · Are allocation, blinding and pressure-measurement bias materials available?

Current findings: Designs are preserved as Cohen's multicenter 3-arm randomized trial and Decaux's randomized sham trial. Allocation concealment, assessor blinding, devices, repeated measurements and selective-reporting details are unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Methods, protocols, SAPs, original measurements and amendment histories. A design label does not establish formal RoB/GRADE or passed review.
Required materials and conditions: Allocation, measurement and selective reporting
Materials to obtain first: Methods, protocols, SAPs, original measurements and amendment histories. A design label does not establish formal RoB/GRADE or passed review.
Further research: Material needed: Methods, protocols, SAPs, original measurements and amendment histories. A design label does not establish formal RoB/GRADE or passed review. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Allocation, measurement and selective reporting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Allocation, measurement and selective-reporting conditions with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N23 · Are study conditions separate from actual delivery and cointerventions?

Current findings: Original study descriptions contain training, rest, frequency and phase information. Preserve these as study identifiers. Actual arm adherence, cumulative exposure, concurrent exercise and medication changes are unverified; exposure totals are not calculated.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Actual arm exposure, departures, cointerventions and analysis effects. No execution procedures, intensity-setting methods or medication reduction/replacement instructions.
Required materials and conditions: Intervention identification versus actual exposure
Materials to obtain first: Actual arm exposure, departures, cointerventions and analysis effects. No execution procedures, intensity-setting methods or medication reduction/replacement instructions.
Further research: Material needed: Actual arm exposure, departures, cointerventions and analysis effects. No execution procedures, intensity-setting methods or medication reduction/replacement instructions. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Intervention identification versus actual exposure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Intervention identification versus actual exposure with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N24 · Are acute in-exercise pressure and resting results distinguished?

Current findings: Original safety text records mean 196/112 mmHg during a 90° hold in a separate acute study. This differs from long-term resting results; its bibliography, population and denominators are not separately identified in the current 2 citations.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Acute-study originals, populations, denominators, timing, exposure and links to resting results. Acute values do not create long-term harm rates, event-prevention effects or exercise instructions.
Required materials and conditions: Separate acute timing and report identity
Materials to obtain first: Acute-study originals, populations, denominators, timing, exposure and links to resting results. Acute values do not create long-term harm rates, event-prevention effects or exercise instructions.
Further research: Material needed: Acute-study originals, populations, denominators, timing, exposure and links to resting results. Acute values do not create long-term harm rates, event-prevention effects or exercise instructions. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Separate acute timing and report identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Separate acute timing and report identity with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources

N25 · What is the scope of 0 reported adverse events?

Current findings: Original records say all 77 key-trial participants completed and 0 adverse events were reported. Preserve the limited supervised-sample boundary. Definitions, active collection, arm exposure and specific harm-analysis denominators are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Harm definitions, collection, arm exposure/denominators, withdrawals and original severity tables. 0 reports do not establish complete safety or no harm.
Required materials and conditions: Harm collection, exposure and arm denominators
Materials to obtain first: Harm definitions, collection, arm exposure/denominators, withdrawals and original severity tables. 0 reports do not establish complete safety or no harm.
Further research: Material needed: Harm definitions, collection, arm exposure/denominators, withdrawals and original severity tables. 0 reports do not establish complete safety or no harm. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Harm collection, exposure and arm denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Harm collection, exposure and arm denominators with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N26 · Are long-term/rare harms and post-training effects known?

Current findings: The key trial concerns initial 12-week training and maintenance; the small trial spans 4 weeks. This summary does not establish post-training treatment replacement, cardiovascular events, rare harms, actual long-term events or unsupervised-population details.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Actual long-term follow-up, harm surveillance, endpoint denominators and matching interventions/populations. Short reports or parent caution do not create new long-term safety/efficacy certification.
Required materials and conditions: Short-term/maintenance versus long-term clinical/harm boundaries
Materials to obtain first: Actual long-term follow-up, harm surveillance, endpoint denominators and matching interventions/populations. Short reports or parent caution do not create new long-term safety/efficacy certification.
Further research: Material needed: Actual long-term follow-up, harm surveillance, endpoint denominators and matching interventions/populations. Short reports or parent caution do not create new long-term safety/efficacy certification. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Short-term/maintenance versus long-term clinical/harm boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Short-term/maintenance versus long-term clinical/harm boundaries with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N27 · What would trigger an update?

Current findings: This is a treatment-replacement/cardiovascular-event sheet based on stored materials. Relevant observations can be updated after reviewing external materials, condition details, denominators, endpoints, timing and shared-report links. Independence/grades are not newly established.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: New originals, complete pre-change copies, condition versions, application events and review records. Distinguish material registration from content/verdict changes.
Required materials and conditions: Original material, conditions, observations and verdict changes
Materials to obtain first: New originals, complete pre-change copies, condition versions, application events and review records. Distinguish material registration from content/verdict changes.
Further research: Material needed: New originals, complete pre-change copies, condition versions, application events and review records. Distinguish material registration from content/verdict changes. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original material, conditions, observations and verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Distinguishing source, condition, observation and verdict changes with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.
Application exceptions: Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02