{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v3000-s2",
  "verdict_number": "3000",
  "title": "Wall-sit training × medication replacement and cardiovascular events: directly untested",
  "view_version": "1.0",
  "view_created_date": "2026-10-18",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-09-07",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "Cohen has 77 untreated adults aged 35–65 with hypertension, all completed. Decaux has a separate 30 participants; detailed eligibility, blood-pressure medication, comorbidities and age are unverified. These samples do not fill arm denominators for reducing, stopping or replacing existing medication or for event endpoints.",
    "intervention": "Knee angle, intensity calibration and supervision belong to original supervised isometric wall-squat/wall-sit conditions. Report-specific actual delivery, adherence and cointerventions are unverified. Research identification context is not turned into personal exercise, breathing, medication-change or treatment instructions.",
    "dose": "Distinguish original initial training 3 times weekly for 12 weeks, 4 holds of 2 minutes with 2-minute seated rests, and later maintenance 1 time weekly. Maintenance allocation, denominators and exact results are unverified. 1 time weekly is not treated as an adequate starting dose.",
    "comparator": "Cohen has 3 handgrip, wall-sit and no-exercise arms; Decaux has wall sit, low-intensity sham and no exercise. Direct medication comparison, equivalence, noninferiority and treatment replacement were not tested. Pressure changes or null results do not establish medication equivalence.",
    "endpoint": "The selected questions are medication replacement and cardiovascular-event prevention. Original stored records say these were directly untested. Event counts, risks, between-group effects and CIs are unverified. Resting SBP and DBP are separate pressure outcomes; untested does not mean 0 events or an effect of 0, and pressure signals are not converted into clinical-event effects.",
    "duration": "Distinguish key initial 12-week training and later maintenance, Decaux 4 weeks, and mean 196/112 mmHg during a separate acute 90° hold. These time points do not become long-term event-prevention or treatment-replacement follow-up. Post-training clinical outcomes and the acute study bibliography, population and denominators are unverified.",
    "excluded_extensions": [
      "Converting directly untested into 0 events, an effect of 0, equivalence or no studies at all",
      "Transferring later once-weekly maintenance into a minimum starting dose",
      "Combining resting SBP, DBP and acute in-exercise pressure as one result",
      "Extending a blood-pressure surrogate to medication equivalence, dose reduction/replacement or cardiovascular-event prevention",
      "Adding arms, outcomes, maintenance phases, related reports or sheets into new unique-trial/participant or independent-replication totals",
      "Using original grades, public funding, COI declarations or 0 reported adverse events as new verdicts or independence/safety certification",
      "Creating new numbers, effects, CIs, grades or exercise, breathing, medication reduction/replacement or treatment instructions"
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which treatment-replacement and event-prevention claims are selected?",
      "needed": "Exact medication-replacement and cardiovascular-event claims and original grade",
      "role": "Required",
      "role_reason": "This condition connects Exact medication-replacement and cardiovascular-event claims and original grade with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Exact medication-replacement and cardiovascular-event claims and original grade must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct materials identifying each treatment-replacement and clinical-event question. Do not turn ? into no effect, 0 points or no studies at all. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The selected claims are medication replacement and cardiovascular-event prevention, with original grade ?. Preserve the original note that clinical events and treatment replacement were not tested. Score/status for this question are unrecorded and separate from parent blood-pressure grade C with 54 points.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Direct materials identifying each treatment-replacement and clinical-event question. Do not turn ? into no effect, 0 points or no studies at all.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct materials identifying each treatment-replacement and clinical-event question. Do not turn ? into no effect, 0 points or no studies at all."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Was medication replacement tested directly?",
      "needed": "Direct comparative medication-replacement results",
      "role": "Required",
      "role_reason": "This condition connects Direct comparative medication-replacement results with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Direct comparative medication-replacement results must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Clear medication comparison, treatment-replacement endpoints, stability, rescue treatment and long-term follow-up. No medication-change instructions are written. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original stored records say medication/treatment replacement was not tested. Pressure results for wall sit versus no exercise are not transferred into medication-replacement effects.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Clear medication comparison, treatment-replacement endpoints, stability, rescue treatment and long-term follow-up. No medication-change instructions are written.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Clear medication comparison, treatment-replacement endpoints, stability, rescue treatment and long-term follow-up. No medication-change instructions are written."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Is there comparative evidence of equivalence to medication?",
      "needed": "Direct active-medication comparison and equivalence/noninferiority design",
      "role": "Required",
      "role_reason": "This condition connects Direct active-medication comparison and equivalence/noninferiority design with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Direct active-medication comparison and equivalence/noninferiority design must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct medication control, prospective equivalence/noninferiority margins, analysis populations, CIs and actual treatment conditions. Null P values or SBP reductions do not establish medication equivalence. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The key trial assigned handgrip, wall sit and no exercise; the small trial used wall sit, low-intensity sham and no exercise. Preserve the original record that equivalence to blood-pressure medication was not directly compared.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Direct medication control, prospective equivalence/noninferiority margins, analysis populations, CIs and actual treatment conditions. Null P values or SBP reductions do not establish medication equivalence.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct medication control, prospective equivalence/noninferiority margins, analysis populations, CIs and actual treatment conditions. Null P values or SBP reductions do not establish medication equivalence."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Was the key trial about reducing existing medication?",
      "needed": "Distinguishing untreated participants from people changing existing treatment",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing untreated participants from people changing existing treatment with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Distinguishing untreated participants from people changing existing treatment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Baseline/follow-up medication status, eligibility and cointerventions. Preserve population context without writing reduction/discontinuation instructions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Key participants were untreated adults aged 35–65 with hypertension. These are not presented as reduction, discontinuation or replacement results in people taking blood-pressure medication. Detailed medication conditions in Decaux are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Baseline/follow-up medication status, eligibility and cointerventions. Preserve population context without writing reduction/discontinuation instructions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Baseline/follow-up medication status, eligibility and cointerventions. Preserve population context without writing reduction/discontinuation instructions."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Were cardiovascular clinical events measured directly?",
      "needed": "Event-specific cardiovascular-prevention results",
      "role": "Required",
      "role_reason": "This condition connects Event-specific cardiovascular-prevention results with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Event-specific cardiovascular-prevention results must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Event types, definitions, adjudication, arm events, time at risk, follow-up and competing events. Untested does not mean 0 events or a prevention effect of 0. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original records say cardiovascular/clinical events were not tested. Event counts, risks, between-group event effects and CIs are not established by the stored materials.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Event types, definitions, adjudication, arm events, time at risk, follow-up and competing events. Untested does not mean 0 events or a prevention effect of 0.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Event types, definitions, adjudication, arm events, time at risk, follow-up and competing events. Untested does not mean 0 events or a prevention effect of 0."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Is reduced SBP a direct event-prevention result?",
      "needed": "Distinguishing resting-SBP surrogates from clinical events",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing resting-SBP surrogates from clinical events with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Distinguishing resting-SBP surrogates from clinical events must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct event comparisons and surrogate-to-event links for the relevant population/duration. No new risk-reduction calculations or hypothetical numerical examples. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Key SBP 141.2→128.3 versus 138.9→138.5 mmHg is a resting-pressure result. The original verdict describes pressure as a surrogate. This is not converted into heart-attack/cardiovascular-event prevention effects.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Direct event comparisons and surrogate-to-event links for the relevant population/duration. No new risk-reduction calculations or hypothetical numerical examples.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct event comparisons and surrogate-to-event links for the relevant population/duration. No new risk-reduction calculations or hypothetical numerical examples."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "How does the null DBP result differ from the clinical questions?",
      "needed": "Separating DBP results from treatment-replacement/event-prevention questions",
      "role": "Required",
      "role_reason": "This condition connects Separating DBP results from treatment-replacement/event-prevention questions with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Separating DBP results from treatment-replacement/event-prevention questions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Separate direct treatment-replacement/event materials and DBP analysis tables. Preserve endpoint-specific questions and unverified scope. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The key between-group DBP difference is stored as null. This is not turned into a direct test showing medication-replacement/event-prevention effects of 0. SBP support is not bundled with DBP/event support.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Separate direct treatment-replacement/event materials and DBP analysis tables. Preserve endpoint-specific questions and unverified scope.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Separate direct treatment-replacement/event materials and DBP analysis tables. Preserve endpoint-specific questions and unverified scope."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What does the small 4-week sham trial support?",
      "needed": "Directness boundaries of Decaux pressure results",
      "role": "Required",
      "role_reason": "This condition connects Directness boundaries of Decaux pressure results with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Directness boundaries of Decaux pressure results must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual endpoint hierarchy, medication/event materials and separate direct-question evidence. Short-term pressure support is not counted as independent event-prevention replication. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Decaux has 30 participants over 4 weeks: SBP -15.2±9.2 and DBP -4.6±5.0 mmHg, with P<.05 versus controls. These stored results contain no direct estimate of medication replacement or event prevention.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actual endpoint hierarchy, medication/event materials and separate direct-question evidence. Short-term pressure support is not counted as independent event-prevention replication.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual endpoint hierarchy, medication/event materials and separate direct-question evidence. Short-term pressure support is not counted as independent event-prevention replication."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Do initial and maintenance phases establish long-term event prevention?",
      "needed": "Duration boundaries of initial training and later pressure maintenance",
      "role": "Required",
      "role_reason": "This condition connects Duration boundaries of initial training and later pressure maintenance with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Duration boundaries of initial training and later pressure maintenance must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Phase-specific populations, denominators, actual event follow-up, losses and treatment replacement. Pressure maintenance is not extended into long-term clinical efficacy. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original records distinguish 3 sessions weekly for the first 12 weeks from later 1-session-weekly maintenance. A bibliographic title about maintained SBP is not a long-term cardiovascular-event result or evidence that 1 session weekly suffices from the start.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Phase-specific populations, denominators, actual event follow-up, losses and treatment replacement. Pressure maintenance is not extended into long-term clinical efficacy.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Phase-specific populations, denominators, actual event follow-up, losses and treatment replacement. Pressure maintenance is not extended into long-term clinical efficacy."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are analysis denominators available for events and treatment replacement?",
      "needed": "Distinguishing pressure samples from event/medication endpoint denominators",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing pressure samples from event/medication endpoint denominators with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Distinguishing pressure samples from event/medication endpoint denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Arm analysis denominators, time at risk, missingness, withdrawals and original event tables for direct endpoints. Do not add the reports' n values. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The key trial has 77 participants all completed, and the small trial has 30. These are report-specific pressure-study sizes, not established allocation, analysis or time-at-risk denominators for each event/medication-replacement endpoint.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Arm analysis denominators, time at risk, missingness, withdrawals and original event tables for direct endpoints. Do not add the reports' n values.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Arm analysis denominators, time at risk, missingness, withdrawals and original event tables for direct endpoints. Do not add the reports' n values."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Are cointerventions and rescue treatments verified?",
      "needed": "Medication, other exercise, lifestyle changes and actual controls",
      "role": "Required",
      "role_reason": "This condition connects Medication, other exercise, lifestyle changes and actual controls with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Medication, other exercise, lifestyle changes and actual controls must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Cointerventions, rescue treatment, adherence, intervention departures and treatment-change records. Leave these as material needs without medication-change instructions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Key stored participants were untreated and the actual control was no exercise. Detailed originals on follow-up cointerventions, rescue treatment and medication changes are unverified.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Cointerventions, rescue treatment, adherence, intervention departures and treatment-change records. Leave these as material needs without medication-change instructions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Cointerventions, rescue treatment, adherence, intervention departures and treatment-change records. Leave these as material needs without medication-change instructions."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Were event prevention and medication replacement prospective endpoints?",
      "needed": "Prospective status and analysis plans for direct clinical endpoints",
      "role": "Required",
      "role_reason": "This condition connects Prospective status and analysis plans for direct clinical endpoints with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Prospective status and analysis plans for direct clinical endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original timing, amendment history, prospective clinical endpoints and analysis plans in registration, protocols and SAPs. External registration/plans were not read this time. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original records say these outcomes were not tested, and the parent verdict's prospective endpoint hierarchy is unverified. NCT05025202 in the citation does not verify prospective registration of these claims.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original timing, amendment history, prospective clinical endpoints and analysis plans in registration, protocols and SAPs. External registration/plans were not read this time.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original timing, amendment history, prospective clinical endpoints and analysis plans in registration, protocols and SAPs. External registration/plans were not read this time."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Do 0 reported adverse events establish cardiovascular protection?",
      "needed": "Separating harm collection from cardiovascular-event prevention",
      "role": "Required",
      "role_reason": "This condition connects Separating harm collection from cardiovascular-event prevention with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Separating harm collection from cardiovascular-event prevention must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Harm definitions, collection, arm exposure, denominators, actual event adjudication and long-term follow-up. 0 reports do not establish no harm or cardiovascular protection. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original text says the key 77-participant trial reported 0 adverse events. A separate acute study records pressure responses during holds. These safety contexts are not direct event-prevention results.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Harm definitions, collection, arm exposure, denominators, actual event adjudication and long-term follow-up. 0 reports do not establish no harm or cardiovascular protection.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Harm definitions, collection, arm exposure, denominators, actual event adjudication and long-term follow-up. 0 reports do not establish no harm or cardiovascular protection."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What materials would answer the direct clinical questions?",
      "needed": "Separate direct evidence for medication replacement and event prevention",
      "role": "Required",
      "role_reason": "This condition connects Separate direct evidence for medication replacement and event prevention with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Separate direct evidence for medication replacement and event prevention must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual direct medication comparisons, endpoints, CIs and adequate clinical-event follow-up, denominators and definitions. Record needed materials without new research, independence certification or treatment instructions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Current stored materials concern small supervised resting-pressure studies; direct medication-replacement/cardiovascular-event evidence is unverified. Keep material needs separate for the clinical questions.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actual direct medication comparisons, endpoints, CIs and adequate clinical-event follow-up, denominators and definitions. Record needed materials without new research, independence certification or treatment instructions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual direct medication comparisons, endpoints, CIs and adequate clinical-event follow-up, denominators and definitions. Record needed materials without new research, independence certification or treatment instructions."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Are shared reports being counted as new trials?",
      "needed": "Links among reports, trials and selected questions",
      "role": "Required",
      "role_reason": "This condition connects Links among reports, trials and selected questions with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Links among reports, trials and selected questions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report, cohort and analysis-population identifiers and shared relationships. No new unique-trial/participant totals or independent-replication certification. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Parent verdict 3000 and its subclaim questions share the Cohen/Decaux reports. Report/sheet counts and 77/30 participants are not made into new independent-trial/participant totals. Unique-trial counts and unique-participant totals are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Report, cohort and analysis-population identifiers and shared relationships. No new unique-trial/participant totals or independent-replication certification.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report, cohort and analysis-population identifiers and shared relationships. No new unique-trial/participant totals or independent-replication certification."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Which materials were actually read?",
      "needed": "Distinguishing stored summaries from external originals",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing stored summaries from external originals with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Distinguishing stored summaries from external originals must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actually acquired originals, supplements and access records. A URL or historical verification statement does not become current full-text reading or a met condition. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The complete stored parent-verdict summary was read and a copy preserved. PubMed URLs, PMCID, DOI and NCT values come from original bibliographies. External abstracts, full texts, registration, protocols and SAPs were unread this time.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actually acquired originals, supplements and access records. A URL or historical verification statement does not become current full-text reading or a met condition.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actually acquired originals, supplements and access records. A URL or historical verification statement does not become current full-text reading or a met condition."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Where are bibliographies and registration identifiers recorded?",
      "needed": "Report-specific bibliographic/registration locations",
      "role": "Required",
      "role_reason": "This condition connects Report-specific bibliographic/registration locations with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Report-specific bibliographic/registration locations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Paper/registration identities, dates and material links. Do not infer new URLs from identifiers or claim registration contents were verified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Cohen has PMID 36965163, PMCID PMC10085809 and DOI 10.1111/jch.14621. Decaux has PMID 35083878, PMCID PMC8792514, DOI 10.14814/phy2.15112 and NCT05025202. NCT appears in the Decaux citation; evidence summaries have no separate registration field.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Paper/registration identities, dates and material links. Do not infer new URLs from identifiers or claim registration contents were verified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Paper/registration identities, dates and material links. Do not infer new URLs from identifiers or claim registration contents were verified."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "How are original languages and historical verification statements preserved?",
      "needed": "Original Korean/English wording, selected-claim notes and historical scope",
      "role": "Required",
      "role_reason": "This condition connects Original Korean/English wording, selected-claim notes and historical scope with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Original Korean/English wording, selected-claim notes and historical scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Review of originals, translations and corrections. Historical verification wording is not relabeled as passing current review. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserve original Korean/English wording, selected claims/notes and historical key/sham RCT, funding and acute-safety verification statements from the parent verdict. This production is not a new content review or external-original cross-check.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Review of originals, translations and corrections. Historical verification wording is not relabeled as passing current review.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Review of originals, translations and corrections. Historical verification wording is not relabeled as passing current review."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Are selected-question grades/axes separate from the parent verdict?",
      "needed": "Selected original grade, absent score and parent context",
      "role": "Required",
      "role_reason": "This condition connects Selected original grade, absent score and parent context with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Selected original grade, absent score and parent context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Review of selected-question boundaries/content. No new scoring, axis changes or copying of parent scores. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserve selected original grade ? and its note; score/status are unrecorded. Parent C 54, caution and B/S/R1/I2/E+/B1/CX axes are pressure-verdict context. They are not transferred into treatment-replacement/cardiovascular-event scores or independence certification.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Review of selected-question boundaries/content. No new scoring, axis changes or copying of parent scores.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Review of selected-question boundaries/content. No new scoring, axis changes or copying of parent scores."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "What are the evidence date and correction records?",
      "needed": "Distinguishing the original date and empty records from production",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing the original date and empty records from production with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Distinguishing the original date and empty records from production must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Latest corrections, follow-up materials and original histories. No arbitrary new evidence date, correction or verdict value. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original evidence date is 2026-09-07; corrections are an empty array and deliberation an empty string. These are not production/review dates or certification that no external corrections exist.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Latest corrections, follow-up materials and original histories. No arbitrary new evidence date, correction or verdict value.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Latest corrections, follow-up materials and original histories. No arbitrary new evidence date, correction or verdict value."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Are funding, product support, employee authors and analysis involvement distinguished?",
      "needed": "Report-specific funding and company-related items",
      "role": "Required",
      "role_reason": "This condition connects Report-specific funding and company-related items with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Report-specific funding and company-related items must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific funding, support, affiliations and analysis/publication-role originals. Unprovided funding does not mean no company; parent I2 is not newly certified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Cohen is stored as Colombian Ministry of Science/Colciencias with no COI declared; Decaux has funding information not provided. Public funding/COI declarations differ from detailed verification of product support, company employee authors and company analysis/reporting involvement.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Report-specific funding, support, affiliations and analysis/publication-role originals. Unprovided funding does not mean no company; parent I2 is not newly certified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report-specific funding, support, affiliations and analysis/publication-role originals. Unprovided funding does not mean no company; parent I2 is not newly certified."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Are allocation, blinding and pressure-measurement bias materials available?",
      "needed": "Allocation, measurement and selective reporting",
      "role": "Required",
      "role_reason": "This condition connects Allocation, measurement and selective-reporting conditions with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Allocation, measurement and selective reporting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Methods, protocols, SAPs, original measurements and amendment histories. A design label does not establish formal RoB/GRADE or passed review. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Designs are preserved as Cohen's multicenter 3-arm randomized trial and Decaux's randomized sham trial. Allocation concealment, assessor blinding, devices, repeated measurements and selective-reporting details are unverified.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Methods, protocols, SAPs, original measurements and amendment histories. A design label does not establish formal RoB/GRADE or passed review.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Methods, protocols, SAPs, original measurements and amendment histories. A design label does not establish formal RoB/GRADE or passed review."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Are study conditions separate from actual delivery and cointerventions?",
      "needed": "Intervention identification versus actual exposure",
      "role": "Required",
      "role_reason": "This condition connects Intervention identification versus actual exposure with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Intervention identification versus actual exposure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual arm exposure, departures, cointerventions and analysis effects. No execution procedures, intensity-setting methods or medication reduction/replacement instructions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original study descriptions contain training, rest, frequency and phase information. Preserve these as study identifiers. Actual arm adherence, cumulative exposure, concurrent exercise and medication changes are unverified; exposure totals are not calculated.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actual arm exposure, departures, cointerventions and analysis effects. No execution procedures, intensity-setting methods or medication reduction/replacement instructions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual arm exposure, departures, cointerventions and analysis effects. No execution procedures, intensity-setting methods or medication reduction/replacement instructions."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Are acute in-exercise pressure and resting results distinguished?",
      "needed": "Separate acute timing and report identity",
      "role": "Supplementary",
      "role_reason": "This condition connects Separate acute timing and report identity with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Separate acute timing and report identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Acute-study originals, populations, denominators, timing, exposure and links to resting results. Acute values do not create long-term harm rates, event-prevention effects or exercise instructions. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original safety text records mean 196/112 mmHg during a 90° hold in a separate acute study. This differs from long-term resting results; its bibliography, population and denominators are not separately identified in the current 2 citations.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Acute-study originals, populations, denominators, timing, exposure and links to resting results. Acute values do not create long-term harm rates, event-prevention effects or exercise instructions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Acute-study originals, populations, denominators, timing, exposure and links to resting results. Acute values do not create long-term harm rates, event-prevention effects or exercise instructions."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "What is the scope of 0 reported adverse events?",
      "needed": "Harm collection, exposure and arm denominators",
      "role": "Supplementary",
      "role_reason": "This condition connects Harm collection, exposure and arm denominators with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Harm collection, exposure and arm denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Harm definitions, collection, arm exposure/denominators, withdrawals and original severity tables. 0 reports do not establish complete safety or no harm. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original records say all 77 key-trial participants completed and 0 adverse events were reported. Preserve the limited supervised-sample boundary. Definitions, active collection, arm exposure and specific harm-analysis denominators are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Harm definitions, collection, arm exposure/denominators, withdrawals and original severity tables. 0 reports do not establish complete safety or no harm.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Harm definitions, collection, arm exposure/denominators, withdrawals and original severity tables. 0 reports do not establish complete safety or no harm."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are long-term/rare harms and post-training effects known?",
      "needed": "Short-term/maintenance versus long-term clinical/harm boundaries",
      "role": "Supplementary",
      "role_reason": "This condition connects Short-term/maintenance versus long-term clinical/harm boundaries with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Short-term/maintenance versus long-term clinical/harm boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual long-term follow-up, harm surveillance, endpoint denominators and matching interventions/populations. Short reports or parent caution do not create new long-term safety/efficacy certification. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The key trial concerns initial 12-week training and maintenance; the small trial spans 4 weeks. This summary does not establish post-training treatment replacement, cardiovascular events, rare harms, actual long-term events or unsupervised-population details.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actual long-term follow-up, harm surveillance, endpoint denominators and matching interventions/populations. Short reports or parent caution do not create new long-term safety/efficacy certification.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual long-term follow-up, harm surveillance, endpoint denominators and matching interventions/populations. Short reports or parent caution do not create new long-term safety/efficacy certification."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "What would trigger an update?",
      "needed": "Original material, conditions, observations and verdict changes",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing source, condition, observation and verdict changes with directly untested medication replacement/equivalence and cardiovascular-event prevention, blood-pressure surrogates, and population, denominator, duration and harm boundaries.",
      "application_exception": "Preserve selected original grade ? and the directly untested note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Untested does not mean 0 events, an effect of 0 or no studies at all. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.",
      "criterion": "Material for Original material, conditions, observations and verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: New originals, complete pre-change copies, condition versions, application events and review records. Distinguish material registration from content/verdict changes. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "This is a treatment-replacement/cardiovascular-event sheet based on stored materials. Relevant observations can be updated after reviewing external materials, condition details, denominators, endpoints, timing and shared-report links. Independence/grades are not newly established.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "New originals, complete pre-change copies, condition versions, application events and review records. Distinguish material registration from content/verdict changes.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "New originals, complete pre-change copies, condition versions, application events and review records. Distinguish material registration from content/verdict changes."
    }
  ],
  "reports": [
    {
      "report_id": "R01",
      "title": "Cohen DD, Aroca-Martinez G, Carreño-Robayo J, et al. Reductions in systolic blood pressure achieved by hypertensives with three isometric training sessions per week are maintained with a single session per week. J Clin Hypertens. 2023;25(4):380-387. PMID: 36965163. PMCID: PMC10085809. DOI: 10.1111/jch.14621.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/36965163/",
      "report_type": "Multicenter three-arm randomized trial",
      "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "study_family": "Original report R01; unique counts and independent replication unverified",
      "independent_replication": "Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report.",
      "observed_result": "SBP 141.2 to 128.3 vs 138.9 to 138.5 mmHg; DBP between-group null",
      "result_level": "Stored summary of a resting-pressure study. This is not a direct comparison of medication replacement, medication equivalence or cardiovascular-event prevention. Endpoint-specific event counts, time at risk, arm analysis denominators, effects and CIs are unverified. No new clinical effect is calculated from pressure reductions or 0 reported adverse events.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred."
        },
        {
          "material_type": "Protocol and analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/36965163/"
        }
      ]
    },
    {
      "report_id": "R02",
      "title": "Decaux A et al. Blood pressure and cardiac autonomic adaptations to isometric exercise training: A randomized sham-controlled study. Physiol Rep. 2022;10(2):e15112. PMID: 35083878. PMCID: PMC8792514. DOI: 10.14814/phy2.15112. NCT05025202.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/35083878/",
      "report_type": "Randomized wall-sit, low-intensity sham, and no-exercise trial",
      "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "study_family": "Original report R02; unique counts and independent replication unverified",
      "independent_replication": "Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report.",
      "observed_result": "SBP -15.2±9.2 and DBP -4.6±5.0 mmHg; P<.05 vs controls",
      "result_level": "Stored summary of a resting-pressure study. This is not a direct comparison of medication replacement, medication equivalence or cardiovascular-event prevention. Endpoint-specific event counts, time at risk, arm analysis denominators, effects and CIs are unverified. No new clinical effect is calculated from pressure reductions or 0 reported adverse events.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred."
        },
        {
          "material_type": "Protocol and analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/35083878/"
        }
      ]
    }
  ],
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Awaiting user review",
    "Met": "Use only within the relevant condition's scope after user review; no automatic display in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report."
  },
  "history": [
    {
      "date": "2026-10-18",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "Public pages and materials were prepared from the existing 27 items. No new clinical search, verification-status change or scoring was performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-18"
}