Wall-sit training × diastolic pressure: key null result, 4-week signal and gaps

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionWhich diastolic-pressure claim is selected?Required	The selection is improved diastolic pressure. Preserve original subclaim D and the note that the key between-group result was null. Absent subclaim score/status differ from parent grade C with 54 points. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Exact subclaim, original grade/note and parent verdict	Material needed: Original DBP definitions, times and comparisons are needed. Do not fill subclaim values with the parent score. This records needed materials; no new research was executed.
2	Partly verified	Full text not readStored summary read	N02 · Evidence conditionWhat is the key trial’s between-group DBP result?Required	Cohen records null between-group DBP alongside SBP. Exact arm DBP values, effects, CIs and P are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Direct between-group 12-week resting DBP	Material needed: Arm values, adjusted effects, 95% CIs, exact P and analysis tables are needed. Null does not establish an effect of 0 or equivalence. This records needed materials; no new research was executed.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionWhat does the small sham trial record for DBP?Required	The 30-participant Decaux trial records 4-week DBP -4.6±5.0 mmHg and P<.05 versus controls. SBP -15.2±9.2 is a separate endpoint. R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	4-week DBP changes versus low-intensity sham/no exercise	Material needed: Estimand, ± definition, comparator-specific effects/CIs/P and arm denominators are needed. Do not convert ±5.0 into a between-group 95% CI. This records needed materials; no new research was executed.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionAre the key null and small supportive results the same?Required	Key 12-week between-group DBP is null; the separate 4-week sham trial records a decrease. Parent records no strict R2 upgrade because protocols, funding and prospective primary confirmation differed. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Report-specific DBP directions, designs and durations	Material needed: Effects, designs/populations, denominators and prospective status for each contrast are needed. Create no pooled effect, independent-replication certification or grade change. This records needed materials; no new research was executed.
5	Partly verified	Full text not readStored summary read	N05 · Evidence conditionIn what setting was resting DBP measured?Required	The key endpoint is 12-week office resting pressure and maintenance; Decaux has 4-week resting SBP/DBP. 24-hour, daytime, nighttime and home DBP values are unverified. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Office versus ambulatory/home pressure	Material needed: Posture, equipment, repeat/averaging rules, assessor, valid denominators and original tables for other settings are needed. Do not transfer office values to other settings. This records needed materials; no new research was executed.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionAre within-group/simple SBP differences DBP effects?Required	Parent -12.9/P<.001, -0.4 and simple -12.5 mmHg are SBP records. -12.5 is not an adjusted estimate; these values/P are not transferred to DBP. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Pressure measures and within-/between-group effects	Material needed: DBP-specific tables and direct between-group effects/CIs are needed. Preserve the SBP simple difference as historical; calculate nothing new. This records needed materials; no new research was executed.
7	Unverified	Full text not readStored summary read	N07 · Evidence conditionIs DBP precision verified?Required	The key report preserves null DBP wording; the small trial preserves -4.6±5.0 and P<.05. Exact comparator-specific CIs/P and the ± definition are unverified. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Analysis unit, effects, intervals and exact tests	Material needed: Plans, tables/appendices, models, CIs, variance definitions and missing-data handling are needed. P thresholds or sample size alone do not establish precision. This records needed materials; no new research was executed.
8	Partly verified	Full text not readStored summary read	N08 · Evidence conditionAre the populations the same?Required	The key population is 77 untreated adults aged 35–65 with hypertension. Decaux has 30 participants; detailed eligibility, medication and comorbidities are unverified. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Untreated hypertension versus the separate sham population	Material needed: Decaux eligibility, baseline pressure, medication and age, plus Cohen arm baselines, are needed. Do not automatically treat the populations as identical untreated hypertension. This records needed materials; no new research was executed.
9	Partly verified	Full text not readStored summary read	N09 · Evidence conditionWhat are the actual comparators and DBP contrasts?Required	Cohen has 3 handgrip, wall-sit and no-exercise arms; Decaux has wall sit, low-intensity sham and no exercise. P<.05 versus controls does not provide each detailed comparator test. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Handgrip, wall sit/no exercise versus low-intensity sham	Material needed: Arm allocation, intensity, cointerventions and comparator-specific DBP models/results are needed. Do not relabel handgrip sham or copy one effect to every control. This records needed materials; no new research was executed.
10	Partly verified	Full text not readStored summary read	N10 · Evidence conditionAre initial and maintenance DBP distinguished?Required	Distinguish initial 12 weeks at 3 times weekly, later maintenance 1 time weekly, and the small 4-week trial. Separate between-group maintenance DBP effects/CIs are unverified. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Initial/maintenance versus separate short-term results	Material needed: Stage-specific times, denominators, tables and post-training follow-up are needed. Do not extend maintenance to an adequate starting frequency or persistent DBP effects. This records needed materials; no new research was executed.
11	Partly verified	Full text not readStored summary read	N11 · Evidence conditionAre supervision and intensity retained in scope?Required	Supervised wall sits, knee angle and intensity calibration are parts of the original intervention. This is research identification context, not personal exercise or home-DBP efficacy guidance. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Supervision, knee angle, intensity and delivery context	Material needed: Report-specific supervision, intensity, adherence and cointerventions are needed. Create no exercise prescription. This records needed materials; no new research was executed.
12	Partly verified	Full text not readStored summary read	N12 · Evidence conditionWhat are the original DBP denominators?Required	The key trial has all 77 completed; Decaux has 30 participants. Arm DBP analysis denominators, valid values at each time and missing-data handling are unverified. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Allocation/completion versus arm DBP analysis denominators	Material needed: Arm allocation/completion/analysis flow and populations are needed. Do not reuse overall counts for every arm/endpoint or add report counts. This records needed materials; no new research was executed.
13	Unverified	Full text not readStored summary read	N13 · Evidence conditionIs DBP’s prospective endpoint status verified?Required	Parent leaves exact between-group 95% CIs and prospective hierarchy unverified. NCT05025202 alone does not establish Decaux DBP as a prospective primary outcome or confirm multiplicity plans. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	1st/2nd outcomes, prospective times and multiplicity	Material needed: Dated registration, protocols, SAPs, changes, DBP hierarchy, times and multiplicity plans are needed. External material was not read in this conversion. This records needed materials; no new research was executed.
14	Partly verified	Full text not readStored summary read	N14 · Evidence conditionDoes DBP establish events or medication replacement?Required	Parent describes resting pressure as a surrogate and records that medication replacement/cardiovascular events were not tested. The small DBP signal is not transferred to those endpoints. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Resting DBP versus patient-important outcomes	Material needed: DBP clinical-importance thresholds and separate event/medication comparisons are needed. Create no event-prevention or treatment-replacement conclusion. This records needed materials; no new research was executed.
15	Partly verified	Full text not readStored summary read	N15 · Evidence conditionAre shared reports being counted as new trials?Required	Parent 3000 and existing subclaims share Cohen/Decaux reports. Report/sheet counts or 77/30 participants are not new independent-trial/participant totals. Unique totals are unverified. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Reports, trials, selected questions and shared samples	Material needed: Report, cohort and analysis-population identity and overlap material are needed. No new unique totals or independent-replication certification are created. This records needed materials; no new research was executed.
16	Partly verified	Full text not readStored summary read	N16 · Evidence conditionWhich materials were actually read?Required	The complete parent stored summary was used. PubMed, PMCID, DOI and NCT are original bibliographic values; external abstracts, full texts, registration and protocols/SAPs are unread. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Stored summaries versus external access	Material needed: Actual originals, appendices and access records are needed. URLs or historical verification do not establish current reading or fulfillment. This records needed materials; no new research was executed.
17	Partly verified	Full text not readStored summary read	N17 · Evidence conditionWhere are bibliographies and registration identifiers recorded?Required	Cohen has PMID 36965163, PMCID PMC10085809 and DOI 10.1111/jch.14621; Decaux has PMID 35083878, PMCID PMC8792514, DOI 10.14814/phy2.15112 and NCT05025202. The NCT is in Decaux’s citation; neither evidence summary has a registration field. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Report-specific bibliography and identifier locations	Material needed: Original-paper/registration identity, dates and links are needed. Infer no new URL from identifiers or actual registration reading. This records needed materials; no new research was executed.
18	Partly verified	Full text not readStored summary read	N18 · Evidence conditionHow are both languages and historical checks preserved?Required	Preserve both languages, the selected claim/note and parent historical key/sham RCT, funding and acute-safety verification wording. This conversion is no new clinical content review or original-source cross-check. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Both languages, selected note and historical scope	Material needed: Original text, translation and correction review are needed. Historical verification is not a current clinical-review pass. This records needed materials; no new research was executed.
19	Partly verified	Full text not readStored summary read	N19 · Evidence conditionAre subclaim values distinct from parent grades/axes?Required	Preserve the original subclaim grade/note and absent score/status. Parent grade C with 54 points, caution and B/S/R1/I2/E+/B1/CX are parent context, not a selected DBP score or independence certification. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original subclaim grade/note and absent values versus parent context	Material needed: Selected-question boundary/content review is needed. Do not rescore, revise axes or copy the parent score. This records needed materials; no new research was executed.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionWhat are the evidence date and correction records?Required	Preserve original evidence date 2026-09-07, empty corrections and empty deliberation string. These are not production/review dates or certification of no external corrections. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original date/empty records versus production date	Material needed: Current corrections, follow-up material and source history are needed. Do not inject new dates, corrections or verdict values. This records needed materials; no new research was executed.
21	Partly verified	Full text not readStored summary read	N21 · Evidence conditionAre funding, support, employed authors and analysis roles distinct?Required	Preserve Cohen’s Colombian Ministry of Science/Colciencias support/no-COI declaration and Decaux’s funding information not provided. Product support, company-employed authors and analysis/reporting involvement require separate verification. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Report-specific funding and company involvement	Material needed: Original funding, support, affiliations and analysis/publication roles are needed. Missing information is not no company involvement; parent I2 is not newly certified. This records needed materials; no new research was executed.
22	Unverified	Full text not readStored summary read	N22 · Evidence conditionAre allocation, blinding and measurement-bias materials verified?Required	Preserve Cohen’s multicenter 3-arm randomized design and Decaux’s randomized sham design. Detailed concealment, assessor blinding, equipment, repeats and selective reporting are unverified. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Allocation, measurement and selective reporting	Material needed: Methods, protocols/SAPs, measurements and change history are needed. Design names alone do not establish official appraisal or completed clinical review. This records needed materials; no new research was executed.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionIs delivery context distinct from actual exposure?Required	Preserve original training, rest, frequency and stage records as identification context. Arm-specific actual adherence, cumulative exposure and concurrent exercise/medication changes are unverified. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Intervention identity, adherence and cointerventions	Material needed: Arm exposure, deviations, cointerventions and analysis impact are needed. Create no exposure total, procedure, intensity-calibration method or medication-change instructions. This records needed materials; no new research was executed.
24	Partly verified	Full text not readStored summary read	N24 · Evidence conditionAre acute in-exercise and resting pressure the same?Supplementary	Parent records mean 196/112 mmHg during a separate acute 90° hold. This differs from longer-term resting results; its bibliography, population and denominators are not separately identified in the current 2 citations.	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Acute timing and separate-report identity	Material needed: Acute originals, populations/denominators, times, exposure and resting-result links are needed. Create no long-term harm rate, event-prevention effect or exercise method from acute values. This records needed materials; no new research was executed.
25	Partly verified	Full text not readStored summary read	N25 · Evidence conditionWhat is the scope of 0 reported adverse events?Supplementary	Parent records all 77 key-trial participants completed and 0 reported adverse events. It is a limited supervised sample; definitions, active collection, arm exposures and harm-analysis denominators are unverified. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Harm definitions, collection, exposure and arm denominators	Material needed: Definitions, collection, exposure/denominators, deviations and severity tables are needed. 0 is not complete safety or no harms. This records needed materials; no new research was executed.
26	Unverified	Full text not readStored summary read	N26 · Evidence conditionAre long-term/rare harms and post-training effects known?Supplementary	Distinguish key initial 12-week/maintenance context from the small 4-week trial. Post-training DBP, rare harms, long-term actual events and unsupervised populations are unverified. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Short-term/maintenance versus long-term harms and clinical boundaries	Material needed: Long-term follow-up, surveillance, endpoint denominators and matched interventions/populations are needed. Short-term reports or caution status do not create long-term safety/efficacy certification. This records needed materials; no new research was executed.
27	Partly verified	Full text not readStored summary read	N27 · Evidence conditionWhich materials would trigger an update?Required	This is a DBP sheet based on stored material. Review of original material, conditions, denominators, endpoints/times and shared reports can support updates to relevant observations. R01 R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original material, conditions, observations and verdict changes	Material needed: New original material, complete prechange preservation, criteria versions, applied changes and review history are needed. Create no new clinical research, calculation, verdict or exercise/medication/treatment instructions. This records needed materials; no new research was executed.

No items match your search or filter.

27 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-09-07
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: Cohen has 77 untreated adults aged 35–65 with hypertension, all completed. Decaux has a separate 30 participants; detailed eligibility, blood-pressure medication, comorbidities and age are unverified. The reports are not certified as the same population or used to fill arm-specific analysis denominators for each pressure measure.
Ingredient, formulation and route: Knee angle, intensity calibration and supervision belong to original supervised isometric wall-squat/wall-sit conditions. Report-specific actual delivery, adherence and cointerventions are unverified. Research identification context is not turned into personal exercise, breathing, medication-change or treatment instructions.
Dose: Distinguish original initial training 3 times weekly for 12 weeks, 4 holds of 2 minutes with 2-minute seated rests, and later maintenance 1 time weekly. Maintenance allocation, denominators and exact results are unverified. 1 time weekly is not treated as an adequate starting dose.
Comparator: Cohen has 3 handgrip, wall-sit and no-exercise arms; Decaux has wall sit, low-intensity sham and no exercise. Arm denominators, intensity, contact, expectations and models for each DBP contrast are unverified. Handgrip is not relabeled sham, nor is one effect assigned to all comparators. Direct medication comparisons were not tested.
Measured outcome: The selection is resting DBP. The key 12-week between-group result is null; exact DBP values, effects/CIs/P are unverified. Distinguish separate 4-week DBP -4.6±5.0 mmHg/P<.05 versus controls from SBP -15.2±9.2. The ± is not a between-group 95% CI and its definition is unverified. Within-group SBP -12.9/P<.001, -0.4 and historical simple -12.5 are not DBP effects.
Duration: Distinguish key initial 12-week training and later maintenance, Decaux 4 weeks, and mean 196/112 mmHg during a separate acute 90° hold. DBP maintenance, post-training and long-term effects, and the acute study bibliography, population and denominators are unverified. Do not extend this to pressure in other settings, medication replacement or cardiovascular events.
Questions outside this scope: Transferring key null DBP into an effect of 0/equivalence or a small supportive result into independent confirmation under the same conditions; Transferring within-group SBP changes/P, historical simple differences or ± into between-group DBP effects/95% CIs; Transferring later once-weekly maintenance into a minimum starting dose; Combining resting SBP, DBP and acute in-exercise pressure as one result; Extending a blood-pressure surrogate to medication equivalence, dose reduction/replacement or cardiovascular-event prevention; Adding arms, outcomes, maintenance phases, related reports or sheets into new unique-trial/participant or independent-replication totals; Using original grades, public funding, COI declarations or 0 reported adverse events as new verdicts or independence/safety certification; Creating new numbers, effects, CIs, grades or exercise, breathing, medication reduction/replacement or treatment instructions

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

R01 · Cohen DD, Aroca-Martinez G, Carreño-Robayo J, et al. Reductions in systolic blood pressure achieved by hypertensives with three isometric training sessions per week are maintained with a single session per week. J Clin Hypertens. 2023;25(4):380-387. PMID: 36965163. PMCID: PMC10085809. DOI: 10.1111/jch.14621.

PubMed

Material type: Multicenter three-arm randomized trial
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary: SBP 141.2 to 128.3 vs 138.9 to 138.5 mmHg; DBP between-group null
Record level: Key stored report for the selected DBP question. Preserve 77 participants all completed and null between-group 12-week office resting DBP; exact arm DBP values, effects, 95% CIs, P, denominators and prospective hierarchy are unverified. Null does not establish an effect of 0 or equivalence. Original SBP 141.2→128.3 versus 138.9→138.5 mmHg and within-group/simple differences are parent context, not DBP values.
Study overlap and independent replication: Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.

R02 · Decaux A et al. Blood pressure and cardiac autonomic adaptations to isometric exercise training: A randomized sham-controlled study. Physiol Rep. 2022;10(2):e15112. PMID: 35083878. PMCID: PMC8792514. DOI: 10.14814/phy2.15112. NCT05025202.

PubMed

Material type: Randomized wall-sit, low-intensity sham, and no-exercise trial
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary: SBP -15.2±9.2 and DBP -4.6±5.0 mmHg; P<.05 vs controls
Record level: Preserve separate 30-participant, 4-week wall-sit/low-intensity sham/no-exercise DBP -4.6±5.0 mmHg and P<.05 versus controls. SBP -15.2±9.2 is a separate endpoint. The meaning of ±, arm denominators, exact comparator-specific effects/CIs/P, population and prospective hierarchy are unverified. Do not convert ±5.0 into a 95% CI, or this result into the same 12-week effect or strict independent confirmation.
Study overlap and independent replication: Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred.

Report counts versus independent study counts

Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which diastolic-pressure claim is selected?

Required materials and conditions: Exact subclaim, original grade/note and parent verdict
Conditions for verification: Material for Exact subclaim, original grade/note and parent verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Exact subclaim, original grade/note and parent verdict with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N02 · What is the key trial’s between-group DBP result?

Required materials and conditions: Direct between-group 12-week resting DBP
Conditions for verification: Material for Direct between-group 12-week resting DBP must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Direct between-group 12-week resting DBP with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N03 · What does the small sham trial record for DBP?

Required materials and conditions: 4-week DBP changes versus low-intensity sham/no exercise
Conditions for verification: Material for 4-week DBP changes versus low-intensity sham/no exercise must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects 4-week DBP changes versus low-intensity sham/no exercise with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N04 · Are the key null and small supportive results the same?

Required materials and conditions: Report-specific DBP directions, designs and durations
Conditions for verification: Material for Report-specific DBP directions, designs and durations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Report-specific DBP directions, designs and durations with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N05 · In what setting was resting DBP measured?

Required materials and conditions: Office versus ambulatory/home pressure
Conditions for verification: Material for Office versus ambulatory/home pressure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Office versus ambulatory/home pressure with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N06 · Are within-group/simple SBP differences DBP effects?

Required materials and conditions: Pressure measures and within-/between-group effects
Conditions for verification: Material for Pressure measures and within-/between-group effects must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Pressure measures and within-/between-group effects with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N07 · Is DBP precision verified?

Required materials and conditions: Analysis unit, effects, intervals and exact tests
Conditions for verification: Material for Analysis unit, effects, intervals and exact tests must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Analysis unit, effects, intervals and exact tests with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N08 · Are the populations the same?

Required materials and conditions: Untreated hypertension versus the separate sham population
Conditions for verification: Material for Untreated hypertension versus the separate sham population must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Untreated hypertension versus the separate sham population with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N09 · What are the actual comparators and DBP contrasts?

Required materials and conditions: Handgrip, wall sit/no exercise versus low-intensity sham
Conditions for verification: Material for Handgrip, wall sit/no exercise versus low-intensity sham must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Handgrip, wall sit/no exercise versus low-intensity sham with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N10 · Are initial and maintenance DBP distinguished?

Required materials and conditions: Initial/maintenance versus separate short-term results
Conditions for verification: Material for Initial/maintenance versus separate short-term results must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Initial/maintenance versus separate short-term results with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N11 · Are supervision and intensity retained in scope?

Required materials and conditions: Supervision, knee angle, intensity and delivery context
Conditions for verification: Material for Supervision, knee angle, intensity and delivery context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Supervision, knee angle, intensity and delivery context with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N12 · What are the original DBP denominators?

Required materials and conditions: Allocation/completion versus arm DBP analysis denominators
Conditions for verification: Material for Allocation/completion versus arm DBP analysis denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Allocation/completion versus arm DBP analysis denominators with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N13 · Is DBP’s prospective endpoint status verified?

Required materials and conditions: 1st/2nd outcomes, prospective times and multiplicity
Conditions for verification: Material for 1st/2nd outcomes, prospective times and multiplicity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects 1st/2nd outcomes, prospective times and multiplicity with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N14 · Does DBP establish events or medication replacement?

Required materials and conditions: Resting DBP versus patient-important outcomes
Conditions for verification: Material for Resting DBP versus patient-important outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Resting DBP versus patient-important outcomes with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N15 · Are shared reports being counted as new trials?

Required materials and conditions: Reports, trials, selected questions and shared samples
Conditions for verification: Material for Reports, trials, selected questions and shared samples must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Reports, trials, selected questions and shared samples with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N16 · Which materials were actually read?

Required materials and conditions: Stored summaries versus external access
Conditions for verification: Material for Stored summaries versus external access must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Stored summaries versus external access with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N17 · Where are bibliographies and registration identifiers recorded?

Required materials and conditions: Report-specific bibliography and identifier locations
Conditions for verification: Material for Report-specific bibliography and identifier locations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Report-specific bibliography and identifier locations with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N18 · How are both languages and historical checks preserved?

Required materials and conditions: Both languages, selected note and historical scope
Conditions for verification: Material for Both languages, selected note and historical scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Both languages, selected note and historical scope with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N19 · Are subclaim values distinct from parent grades/axes?

Required materials and conditions: Original subclaim grade/note and absent values versus parent context
Conditions for verification: Material for Original subclaim grade/note and absent values versus parent context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Original subclaim grade/note and absent values versus parent context with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N20 · What are the evidence date and correction records?

Required materials and conditions: Original date/empty records versus production date
Conditions for verification: Material for Original date/empty records versus production date must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Original date/empty records versus production date with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N21 · Are funding, support, employed authors and analysis roles distinct?

Required materials and conditions: Report-specific funding and company involvement
Conditions for verification: Material for Report-specific funding and company involvement must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Report-specific funding and company involvement with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N22 · Are allocation, blinding and measurement-bias materials verified?

Required materials and conditions: Allocation, measurement and selective reporting
Conditions for verification: Material for Allocation, measurement and selective reporting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Allocation, measurement and selective reporting with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N23 · Is delivery context distinct from actual exposure?

Required materials and conditions: Intervention identity, adherence and cointerventions
Conditions for verification: Material for Intervention identity, adherence and cointerventions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Intervention identity, adherence and cointerventions with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N24 · Are acute in-exercise and resting pressure the same?

Required materials and conditions: Acute timing and separate-report identity
Conditions for verification: Material for Acute timing and separate-report identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Acute timing and separate-report identity with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N25 · What is the scope of 0 reported adverse events?

Required materials and conditions: Harm definitions, collection, exposure and arm denominators
Conditions for verification: Material for Harm definitions, collection, exposure and arm denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Harm definitions, collection, exposure and arm denominators with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N26 · Are long-term/rare harms and post-training effects known?

Required materials and conditions: Short-term/maintenance versus long-term harms and clinical boundaries
Conditions for verification: Material for Short-term/maintenance versus long-term harms and clinical boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Short-term/maintenance versus long-term harms and clinical boundaries with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N27 · Which materials would trigger an update?

Required materials and conditions: Original material, conditions, observations and verdict changes
Conditions for verification: Material for Original material, conditions, observations and verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Original material, conditions, observations and verdict changes with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

What the statuses mean

Partly verified: Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified
Unverified: Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety
Review incomplete: Awaiting user review
Met: Use only within the relevant condition's scope after user review; no automatic display in this preparation
Not reported: Distinguish only within materials actually read; do not turn unread external materials into unreported findings
Inaccessible: Not applied during this preparation because actual access was not tested
Not applicable: Use with a reason for non-applicability based on an explicit question boundary
Conflicting data: Judge after actual material comparison; review was not performed during this preparation
Insufficient evidence for the conditions: Do not use as a clinical grade encompassing currently unread materials

Change history

2026-10-16 · Public page/material version 1.0

Public pages and materials were prepared from the existing 27 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-09-07) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which diastolic-pressure claim is selected?

Current findings: The selection is improved diastolic pressure. Preserve original subclaim D and the note that the key between-group result was null. Absent subclaim score/status differ from parent grade C with 54 points.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original DBP definitions, times and comparisons are needed. Do not fill subclaim values with the parent score.
Required materials and conditions: Exact subclaim, original grade/note and parent verdict
Materials to obtain first: Original DBP definitions, times and comparisons are needed. Do not fill subclaim values with the parent score.
Further research: Material needed: Original DBP definitions, times and comparisons are needed. Do not fill subclaim values with the parent score. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Exact subclaim, original grade/note and parent verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Exact subclaim, original grade/note and parent verdict with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N02 · What is the key trial’s between-group DBP result?

Current findings: Cohen records null between-group DBP alongside SBP. Exact arm DBP values, effects, CIs and P are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm values, adjusted effects, 95% CIs, exact P and analysis tables are needed. Null does not establish an effect of 0 or equivalence.
Required materials and conditions: Direct between-group 12-week resting DBP
Materials to obtain first: Arm values, adjusted effects, 95% CIs, exact P and analysis tables are needed. Null does not establish an effect of 0 or equivalence.
Further research: Material needed: Arm values, adjusted effects, 95% CIs, exact P and analysis tables are needed. Null does not establish an effect of 0 or equivalence. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Direct between-group 12-week resting DBP must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Direct between-group 12-week resting DBP with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N03 · What does the small sham trial record for DBP?

Current findings: The 30-participant Decaux trial records 4-week DBP -4.6±5.0 mmHg and P<.05 versus controls. SBP -15.2±9.2 is a separate endpoint.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Estimand, ± definition, comparator-specific effects/CIs/P and arm denominators are needed. Do not convert ±5.0 into a between-group 95% CI.
Required materials and conditions: 4-week DBP changes versus low-intensity sham/no exercise
Materials to obtain first: Estimand, ± definition, comparator-specific effects/CIs/P and arm denominators are needed. Do not convert ±5.0 into a between-group 95% CI.
Further research: Material needed: Estimand, ± definition, comparator-specific effects/CIs/P and arm denominators are needed. Do not convert ±5.0 into a between-group 95% CI. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for 4-week DBP changes versus low-intensity sham/no exercise must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects 4-week DBP changes versus low-intensity sham/no exercise with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02

N04 · Are the key null and small supportive results the same?

Current findings: Key 12-week between-group DBP is null; the separate 4-week sham trial records a decrease. Parent records no strict R2 upgrade because protocols, funding and prospective primary confirmation differed.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Effects, designs/populations, denominators and prospective status for each contrast are needed. Create no pooled effect, independent-replication certification or grade change.
Required materials and conditions: Report-specific DBP directions, designs and durations
Materials to obtain first: Effects, designs/populations, denominators and prospective status for each contrast are needed. Create no pooled effect, independent-replication certification or grade change.
Further research: Material needed: Effects, designs/populations, denominators and prospective status for each contrast are needed. Create no pooled effect, independent-replication certification or grade change. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Report-specific DBP directions, designs and durations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Report-specific DBP directions, designs and durations with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N05 · In what setting was resting DBP measured?

Current findings: The key endpoint is 12-week office resting pressure and maintenance; Decaux has 4-week resting SBP/DBP. 24-hour, daytime, nighttime and home DBP values are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Posture, equipment, repeat/averaging rules, assessor, valid denominators and original tables for other settings are needed. Do not transfer office values to other settings.
Required materials and conditions: Office versus ambulatory/home pressure
Materials to obtain first: Posture, equipment, repeat/averaging rules, assessor, valid denominators and original tables for other settings are needed. Do not transfer office values to other settings.
Further research: Material needed: Posture, equipment, repeat/averaging rules, assessor, valid denominators and original tables for other settings are needed. Do not transfer office values to other settings. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Office versus ambulatory/home pressure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Office versus ambulatory/home pressure with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N06 · Are within-group/simple SBP differences DBP effects?

Current findings: Parent -12.9/P<.001, -0.4 and simple -12.5 mmHg are SBP records. -12.5 is not an adjusted estimate; these values/P are not transferred to DBP.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: DBP-specific tables and direct between-group effects/CIs are needed. Preserve the SBP simple difference as historical; calculate nothing new.
Required materials and conditions: Pressure measures and within-/between-group effects
Materials to obtain first: DBP-specific tables and direct between-group effects/CIs are needed. Preserve the SBP simple difference as historical; calculate nothing new.
Further research: Material needed: DBP-specific tables and direct between-group effects/CIs are needed. Preserve the SBP simple difference as historical; calculate nothing new. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Pressure measures and within-/between-group effects must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Pressure measures and within-/between-group effects with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N07 · Is DBP precision verified?

Current findings: The key report preserves null DBP wording; the small trial preserves -4.6±5.0 and P<.05. Exact comparator-specific CIs/P and the ± definition are unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Plans, tables/appendices, models, CIs, variance definitions and missing-data handling are needed. P thresholds or sample size alone do not establish precision.
Required materials and conditions: Analysis unit, effects, intervals and exact tests
Materials to obtain first: Plans, tables/appendices, models, CIs, variance definitions and missing-data handling are needed. P thresholds or sample size alone do not establish precision.
Further research: Material needed: Plans, tables/appendices, models, CIs, variance definitions and missing-data handling are needed. P thresholds or sample size alone do not establish precision. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Analysis unit, effects, intervals and exact tests must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Analysis unit, effects, intervals and exact tests with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N08 · Are the populations the same?

Current findings: The key population is 77 untreated adults aged 35–65 with hypertension. Decaux has 30 participants; detailed eligibility, medication and comorbidities are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Decaux eligibility, baseline pressure, medication and age, plus Cohen arm baselines, are needed. Do not automatically treat the populations as identical untreated hypertension.
Required materials and conditions: Untreated hypertension versus the separate sham population
Materials to obtain first: Decaux eligibility, baseline pressure, medication and age, plus Cohen arm baselines, are needed. Do not automatically treat the populations as identical untreated hypertension.
Further research: Material needed: Decaux eligibility, baseline pressure, medication and age, plus Cohen arm baselines, are needed. Do not automatically treat the populations as identical untreated hypertension. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Untreated hypertension versus the separate sham population must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Untreated hypertension versus the separate sham population with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N09 · What are the actual comparators and DBP contrasts?

Current findings: Cohen has 3 handgrip, wall-sit and no-exercise arms; Decaux has wall sit, low-intensity sham and no exercise. P<.05 versus controls does not provide each detailed comparator test.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm allocation, intensity, cointerventions and comparator-specific DBP models/results are needed. Do not relabel handgrip sham or copy one effect to every control.
Required materials and conditions: Handgrip, wall sit/no exercise versus low-intensity sham
Materials to obtain first: Arm allocation, intensity, cointerventions and comparator-specific DBP models/results are needed. Do not relabel handgrip sham or copy one effect to every control.
Further research: Material needed: Arm allocation, intensity, cointerventions and comparator-specific DBP models/results are needed. Do not relabel handgrip sham or copy one effect to every control. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Handgrip, wall sit/no exercise versus low-intensity sham must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Handgrip, wall sit/no exercise versus low-intensity sham with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N10 · Are initial and maintenance DBP distinguished?

Current findings: Distinguish initial 12 weeks at 3 times weekly, later maintenance 1 time weekly, and the small 4-week trial. Separate between-group maintenance DBP effects/CIs are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Stage-specific times, denominators, tables and post-training follow-up are needed. Do not extend maintenance to an adequate starting frequency or persistent DBP effects.
Required materials and conditions: Initial/maintenance versus separate short-term results
Materials to obtain first: Stage-specific times, denominators, tables and post-training follow-up are needed. Do not extend maintenance to an adequate starting frequency or persistent DBP effects.
Further research: Material needed: Stage-specific times, denominators, tables and post-training follow-up are needed. Do not extend maintenance to an adequate starting frequency or persistent DBP effects. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Initial/maintenance versus separate short-term results must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Initial/maintenance versus separate short-term results with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N11 · Are supervision and intensity retained in scope?

Current findings: Supervised wall sits, knee angle and intensity calibration are parts of the original intervention. This is research identification context, not personal exercise or home-DBP efficacy guidance.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Report-specific supervision, intensity, adherence and cointerventions are needed. Create no exercise prescription.
Required materials and conditions: Supervision, knee angle, intensity and delivery context
Materials to obtain first: Report-specific supervision, intensity, adherence and cointerventions are needed. Create no exercise prescription.
Further research: Material needed: Report-specific supervision, intensity, adherence and cointerventions are needed. Create no exercise prescription. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Supervision, knee angle, intensity and delivery context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Supervision, knee angle, intensity and delivery context with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N12 · What are the original DBP denominators?

Current findings: The key trial has all 77 completed; Decaux has 30 participants. Arm DBP analysis denominators, valid values at each time and missing-data handling are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm allocation/completion/analysis flow and populations are needed. Do not reuse overall counts for every arm/endpoint or add report counts.
Required materials and conditions: Allocation/completion versus arm DBP analysis denominators
Materials to obtain first: Arm allocation/completion/analysis flow and populations are needed. Do not reuse overall counts for every arm/endpoint or add report counts.
Further research: Material needed: Arm allocation/completion/analysis flow and populations are needed. Do not reuse overall counts for every arm/endpoint or add report counts. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Allocation/completion versus arm DBP analysis denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Allocation/completion versus arm DBP analysis denominators with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N13 · Is DBP’s prospective endpoint status verified?

Current findings: Parent leaves exact between-group 95% CIs and prospective hierarchy unverified. NCT05025202 alone does not establish Decaux DBP as a prospective primary outcome or confirm multiplicity plans.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Dated registration, protocols, SAPs, changes, DBP hierarchy, times and multiplicity plans are needed. External material was not read in this conversion.
Required materials and conditions: 1st/2nd outcomes, prospective times and multiplicity
Materials to obtain first: Dated registration, protocols, SAPs, changes, DBP hierarchy, times and multiplicity plans are needed. External material was not read in this conversion.
Further research: Material needed: Dated registration, protocols, SAPs, changes, DBP hierarchy, times and multiplicity plans are needed. External material was not read in this conversion. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for 1st/2nd outcomes, prospective times and multiplicity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects 1st/2nd outcomes, prospective times and multiplicity with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N14 · Does DBP establish events or medication replacement?

Current findings: Parent describes resting pressure as a surrogate and records that medication replacement/cardiovascular events were not tested. The small DBP signal is not transferred to those endpoints.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: DBP clinical-importance thresholds and separate event/medication comparisons are needed. Create no event-prevention or treatment-replacement conclusion.
Required materials and conditions: Resting DBP versus patient-important outcomes
Materials to obtain first: DBP clinical-importance thresholds and separate event/medication comparisons are needed. Create no event-prevention or treatment-replacement conclusion.
Further research: Material needed: DBP clinical-importance thresholds and separate event/medication comparisons are needed. Create no event-prevention or treatment-replacement conclusion. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Resting DBP versus patient-important outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Resting DBP versus patient-important outcomes with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N15 · Are shared reports being counted as new trials?

Current findings: Parent 3000 and existing subclaims share Cohen/Decaux reports. Report/sheet counts or 77/30 participants are not new independent-trial/participant totals. Unique totals are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Report, cohort and analysis-population identity and overlap material are needed. No new unique totals or independent-replication certification are created.
Required materials and conditions: Reports, trials, selected questions and shared samples
Materials to obtain first: Report, cohort and analysis-population identity and overlap material are needed. No new unique totals or independent-replication certification are created.
Further research: Material needed: Report, cohort and analysis-population identity and overlap material are needed. No new unique totals or independent-replication certification are created. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Reports, trials, selected questions and shared samples must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Reports, trials, selected questions and shared samples with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N16 · Which materials were actually read?

Current findings: The complete parent stored summary was used. PubMed, PMCID, DOI and NCT are original bibliographic values; external abstracts, full texts, registration and protocols/SAPs are unread.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Actual originals, appendices and access records are needed. URLs or historical verification do not establish current reading or fulfillment.
Required materials and conditions: Stored summaries versus external access
Materials to obtain first: Actual originals, appendices and access records are needed. URLs or historical verification do not establish current reading or fulfillment.
Further research: Material needed: Actual originals, appendices and access records are needed. URLs or historical verification do not establish current reading or fulfillment. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Stored summaries versus external access must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Stored summaries versus external access with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N17 · Where are bibliographies and registration identifiers recorded?

Current findings: Cohen has PMID 36965163, PMCID PMC10085809 and DOI 10.1111/jch.14621; Decaux has PMID 35083878, PMCID PMC8792514, DOI 10.14814/phy2.15112 and NCT05025202. The NCT is in Decaux’s citation; neither evidence summary has a registration field.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original-paper/registration identity, dates and links are needed. Infer no new URL from identifiers or actual registration reading.
Required materials and conditions: Report-specific bibliography and identifier locations
Materials to obtain first: Original-paper/registration identity, dates and links are needed. Infer no new URL from identifiers or actual registration reading.
Further research: Material needed: Original-paper/registration identity, dates and links are needed. Infer no new URL from identifiers or actual registration reading. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Report-specific bibliography and identifier locations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Report-specific bibliography and identifier locations with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N18 · How are both languages and historical checks preserved?

Current findings: Preserve both languages, the selected claim/note and parent historical key/sham RCT, funding and acute-safety verification wording. This conversion is no new clinical content review or original-source cross-check.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original text, translation and correction review are needed. Historical verification is not a current clinical-review pass.
Required materials and conditions: Both languages, selected note and historical scope
Materials to obtain first: Original text, translation and correction review are needed. Historical verification is not a current clinical-review pass.
Further research: Material needed: Original text, translation and correction review are needed. Historical verification is not a current clinical-review pass. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Both languages, selected note and historical scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Both languages, selected note and historical scope with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N19 · Are subclaim values distinct from parent grades/axes?

Current findings: Preserve the original subclaim grade/note and absent score/status. Parent grade C with 54 points, caution and B/S/R1/I2/E+/B1/CX are parent context, not a selected DBP score or independence certification.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Selected-question boundary/content review is needed. Do not rescore, revise axes or copy the parent score.
Required materials and conditions: Original subclaim grade/note and absent values versus parent context
Materials to obtain first: Selected-question boundary/content review is needed. Do not rescore, revise axes or copy the parent score.
Further research: Material needed: Selected-question boundary/content review is needed. Do not rescore, revise axes or copy the parent score. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original subclaim grade/note and absent values versus parent context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original subclaim grade/note and absent values versus parent context with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N20 · What are the evidence date and correction records?

Current findings: Preserve original evidence date 2026-09-07, empty corrections and empty deliberation string. These are not production/review dates or certification of no external corrections.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Current corrections, follow-up material and source history are needed. Do not inject new dates, corrections or verdict values.
Required materials and conditions: Original date/empty records versus production date
Materials to obtain first: Current corrections, follow-up material and source history are needed. Do not inject new dates, corrections or verdict values.
Further research: Material needed: Current corrections, follow-up material and source history are needed. Do not inject new dates, corrections or verdict values. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original date/empty records versus production date must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original date/empty records versus production date with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N21 · Are funding, support, employed authors and analysis roles distinct?

Current findings: Preserve Cohen’s Colombian Ministry of Science/Colciencias support/no-COI declaration and Decaux’s funding information not provided. Product support, company-employed authors and analysis/reporting involvement require separate verification.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original funding, support, affiliations and analysis/publication roles are needed. Missing information is not no company involvement; parent I2 is not newly certified.
Required materials and conditions: Report-specific funding and company involvement
Materials to obtain first: Original funding, support, affiliations and analysis/publication roles are needed. Missing information is not no company involvement; parent I2 is not newly certified.
Further research: Material needed: Original funding, support, affiliations and analysis/publication roles are needed. Missing information is not no company involvement; parent I2 is not newly certified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Report-specific funding and company involvement must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Report-specific funding and company involvement with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N22 · Are allocation, blinding and measurement-bias materials verified?

Current findings: Preserve Cohen’s multicenter 3-arm randomized design and Decaux’s randomized sham design. Detailed concealment, assessor blinding, equipment, repeats and selective reporting are unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Methods, protocols/SAPs, measurements and change history are needed. Design names alone do not establish official appraisal or completed clinical review.
Required materials and conditions: Allocation, measurement and selective reporting
Materials to obtain first: Methods, protocols/SAPs, measurements and change history are needed. Design names alone do not establish official appraisal or completed clinical review.
Further research: Material needed: Methods, protocols/SAPs, measurements and change history are needed. Design names alone do not establish official appraisal or completed clinical review. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Allocation, measurement and selective reporting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Allocation, measurement and selective reporting with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N23 · Is delivery context distinct from actual exposure?

Current findings: Preserve original training, rest, frequency and stage records as identification context. Arm-specific actual adherence, cumulative exposure and concurrent exercise/medication changes are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm exposure, deviations, cointerventions and analysis impact are needed. Create no exposure total, procedure, intensity-calibration method or medication-change instructions.
Required materials and conditions: Intervention identity, adherence and cointerventions
Materials to obtain first: Arm exposure, deviations, cointerventions and analysis impact are needed. Create no exposure total, procedure, intensity-calibration method or medication-change instructions.
Further research: Material needed: Arm exposure, deviations, cointerventions and analysis impact are needed. Create no exposure total, procedure, intensity-calibration method or medication-change instructions. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Intervention identity, adherence and cointerventions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Intervention identity, adherence and cointerventions with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N24 · Are acute in-exercise and resting pressure the same?

Current findings: Parent records mean 196/112 mmHg during a separate acute 90° hold. This differs from longer-term resting results; its bibliography, population and denominators are not separately identified in the current 2 citations.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Acute originals, populations/denominators, times, exposure and resting-result links are needed. Create no long-term harm rate, event-prevention effect or exercise method from acute values.
Required materials and conditions: Acute timing and separate-report identity
Materials to obtain first: Acute originals, populations/denominators, times, exposure and resting-result links are needed. Create no long-term harm rate, event-prevention effect or exercise method from acute values.
Further research: Material needed: Acute originals, populations/denominators, times, exposure and resting-result links are needed. Create no long-term harm rate, event-prevention effect or exercise method from acute values. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Acute timing and separate-report identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Acute timing and separate-report identity with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources

N25 · What is the scope of 0 reported adverse events?

Current findings: Parent records all 77 key-trial participants completed and 0 reported adverse events. It is a limited supervised sample; definitions, active collection, arm exposures and harm-analysis denominators are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Definitions, collection, exposure/denominators, deviations and severity tables are needed. 0 is not complete safety or no harms.
Required materials and conditions: Harm definitions, collection, exposure and arm denominators
Materials to obtain first: Definitions, collection, exposure/denominators, deviations and severity tables are needed. 0 is not complete safety or no harms.
Further research: Material needed: Definitions, collection, exposure/denominators, deviations and severity tables are needed. 0 is not complete safety or no harms. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Harm definitions, collection, exposure and arm denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Harm definitions, collection, exposure and arm denominators with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N26 · Are long-term/rare harms and post-training effects known?

Current findings: Distinguish key initial 12-week/maintenance context from the small 4-week trial. Post-training DBP, rare harms, long-term actual events and unsupervised populations are unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Long-term follow-up, surveillance, endpoint denominators and matched interventions/populations are needed. Short-term reports or caution status do not create long-term safety/efficacy certification.
Required materials and conditions: Short-term/maintenance versus long-term harms and clinical boundaries
Materials to obtain first: Long-term follow-up, surveillance, endpoint denominators and matched interventions/populations are needed. Short-term reports or caution status do not create long-term safety/efficacy certification.
Further research: Material needed: Long-term follow-up, surveillance, endpoint denominators and matched interventions/populations are needed. Short-term reports or caution status do not create long-term safety/efficacy certification. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Short-term/maintenance versus long-term harms and clinical boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Short-term/maintenance versus long-term harms and clinical boundaries with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02

N27 · Which materials would trigger an update?

Current findings: This is a DBP sheet based on stored material. Review of original material, conditions, denominators, endpoints/times and shared reports can support updates to relevant observations.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: New original material, complete prechange preservation, criteria versions, applied changes and review history are needed. Create no new clinical research, calculation, verdict or exercise/medication/treatment instructions.
Required materials and conditions: Original material, conditions, observations and verdict changes
Materials to obtain first: New original material, complete prechange preservation, criteria versions, applied changes and review history are needed. Create no new clinical research, calculation, verdict or exercise/medication/treatment instructions.
Further research: Material needed: New original material, complete prechange preservation, criteria versions, applied changes and review history are needed. Create no new clinical research, calculation, verdict or exercise/medication/treatment instructions. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original material, conditions, observations and verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original material, conditions, observations and verdict changes with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.
Application exceptions: Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02